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United States Patent 19 11 Patent Number: 5,648,064 Gaffar Et Al
US005648064A United States Patent 19 11 Patent Number: 5,648,064 Gaffar et al. 45 Date of Patent: Jul. 15, 1997 (54) ORAL COMPOSITIONS HAVING 5,279,816 1/1994 Church et al. ............................ 424/53 ACCELERATED TOOTH WHTENING 5,302,374 4/1994 Wagner ..................................... 424/52 EFFECT 5,302,375 4/1994 Viscio ....................................... 424/53 5,356,554 10/1994 Delwel et al. ........................... 252/94 I76) Inventors: Abdul Gaffar, 89 Carter Rd., Princeton, 5,536,441 7/1996 Chapple et al. ................... 252A186.33 N.J. 08902; Sahar Fakhry-Smith. 7 FOREIGN PATENT DOCUMENTS Ryans Ct. Bordentown, N.J. 08505 0237111 9/1987 European Pat. Off. ......... C11D 3/39 (21) Appl. No.: 499,532 Primary Examiner-Shep K. Rose Attorney, Agent, or Firm-Paul Shapiro (22 Filed: Jul. 7, 1995 57 ABSTRACT (51] Int. Cl. .................. A61K 7/16; A61K7/20 52 U.S. Cl. ............................................... 424/53; 424/49 A two component whitening dentifrice composition is dis 58) Field of Search ................................... 424/53. 49-58 closed which comprises a first component containing a peroxygen compound such as hydrogen peroxide and a (56) References Cited second dentifrice component containing a manganese coor dination complex compound such as manganese gluconate, U.S. PATENT DOCUMENTS which activates the peroxygen compound and accelerates 4,728,455 3/1988 Rerek ........................................ 25299 the release of active oxygen for rapid whitening action, the 4,759,956 7/1988 Amer et al. ... 427/213 first and second components being maintained separate from 5,032,178 7/1991 Cornell ..................................... 106/35 the other until dispensed for application to teeth. 5, 194416 3/1993 Jureller et al. -
Surface Morphology Alterations in Bovine Dentin Exposed to Different Bleaching Agents
Braz J Oral Sci. Original Article January/March 2009 - Volume 8, Number 1 Surface morphology alterations in bovine dentin exposed to different bleaching agents Juliana Nascimento Santos1, Daniel Pinto de Oliveira1, Fábio Roberto Dametto1, Brenda Paula Figueiredo de Almeida Gomes2, Alexandre Augusto Zaia2, José Flávio Affonso de Almeida2, Caio Cezar Randi Ferraz2 1 DDS, MSc, PhD, Department of Restorative Dentistry and Endodontics, Faculdade de Odontologia de Piracicaba, Universidade Estadual de Campinas (Unicamp), Piracicaba (SP), Brazil 2 DDS, MSc, PhD, Professor, Department of Restorative Dentistry, Endodontics, Faculdade de Odontologia de Piracicaba, Unicamp, Piracicaba (SP), Brazil Abstract Aim: This study evaluated the morphological changes caused by internal bleaching agents on dentin surface. Methods: Twenty crowns of bovine incisors were cut into slabs that were randomly distributed in six experimental groups (n = 5), according to the bleaching agent used: G1 – sodium perborate + water, G2 – sodium perborate + 2% chlorhexidine gel, G3 – sodium perborate + 30% hydrogen peroxide, G4 – 30% hydrogen peroxide, G5 – 37% carbamide peroxide and G6 – gel base without carbamide. Two Control Groups were used: C1 with distilled water and C2 with 2% chlorhexidine gel. The specimens were immersed in the respective test bleaching agent and incubated at 37 °C for seven days. Following, they were prepared for scanning electron microscopy and five images from each tooth segment were recorded and analyzed for surface morphological alterations, by three previously calibrated examiners. Inter-examiner agreement was verified using the Kappa test. The rank averages obtained for the groups were subjected to Kruskal-Wallis analysis of variance at 5% significance level. Results: The analysis of the scores obtained indicated that all tested materials caused some morphological alteration on dentin, except for sodium perborate + water (G1) and Control Groups 1 and 2. -
Hexafluorosilicic Acid
Sodium Hexafluorosilicate [CASRN 16893-85-9] and Fluorosilicic Acid [CASRN 16961-83-4] Review of Toxicological Literature October 2001 Sodium Hexafluorosilicate [CASRN 16893-85-9] and Fluorosilicic Acid [CASRN 16961-83-4] Review of Toxicological Literature Prepared for Scott Masten, Ph.D. National Institute of Environmental Health Sciences P.O. Box 12233 Research Triangle Park, North Carolina 27709 Contract No. N01-ES-65402 Submitted by Karen E. Haneke, M.S. (Principal Investigator) Bonnie L. Carson, M.S. (Co-Principal Investigator) Integrated Laboratory Systems P.O. Box 13501 Research Triangle Park, North Carolina 27709 October 2001 Toxicological Summary for Sodium Hexafluorosilicate [16893-85-9] and Fluorosilicic Acid [16961-83-4] 10/01 Executive Summary Nomination Sodium hexafluorosilicate and fluorosilicic acid were nominated for toxicological testing based on their widespread use in water fluoridation and concerns that if they are not completely dissociated to silica and fluoride in water that persons drinking fluoridated water may be exposed to compounds that have not been thoroughly tested for toxicity. Nontoxicological Data Analysis and Physical-Chemical Properties Analytical methods for sodium hexafluorosilicate include the lead chlorofluoride method (for total fluorine) and an ion-specific electrode procedure. The percentage of fluorosilicic acid content for water supply service application can be determined by the specific-gravity method and the hydrogen titration method. The American Water Works Association (AWWA) has specified that fluorosilicic acid contain 20 to 30% active ingredient, a maximum of 1% hydrofluoric acid, a maximum of 200 mg/kg heavy metals (as lead), and no amounts of soluble mineral or organic substance capable of causing health effects. -
The Treatment of Acute Neerotizing Ulcerative Gingivitis Anne C
Penodontics The treatment of acute neerotizing ulcerative gingivitis Anne C. Hartnett* / Jacob Shiloah** The destruction of tbe interdental papillae and formation of permanent gingiva! craierx are common sequelae of acute neerotizing uleerative gingivitis. These craters ean be disfiguring, especially in the anterior gingiva, and ean act as a nidus for recurrent epi- sodes. Traditional therapy has emphasized a stirgieal approach for elimination of Ihese defects, often increasing the esthelie problems. The pwpose of this paper is to review the treatment modalities of acitte neerotizing itlcerative gingivitis and ¡Ilústrate an al- ternative treatment approach of periodic sealing, root planing, and antimicrohiai rinses with 0.12% chlorhexidine. With this therapeutic regimen, the disease proeess ean be reversed and damaged papillae may regenérale. (Quintessence Int 1991:22:95-100.) Introduction chetes, fusifonn bacteria, and species of Bacteroides are the organisms most frequently cultivated from Acute neerotizing ulcerative gingivitis (ANUG) is a these lesions,' a definitive periodontal pathogen has rapidly destructive, noncommunicable, gingival infec- yet to be tmplicated in the onset or progression of tion of complex etiology. It is characterized by necrosis ANUG. A susceptible animal model in which to study of the crest of the gingival papillae, spontaneous ANUG has not been found. bleeding, pain, and halitosis. If left untreated, it may Previous studies have speculated on the importance spread laterally and apically to involve the entire -
Entodinternational.Com ENTOD HOUSE, W-50(B), M.I.D.C, T.T.C
Since 1977... Ocular Care & Wellness Since 1977 OUR OPHTHALMIC • Over 40 Years of Pharmaceutical & Nutraceutical Expertise RANGE AT A GLANCE • International Formulation R&D Centres • Technology-Driven Ophthalmics • WHO GMP & US FDA Accredited Manufacturing • Global Exports CONTACT US Head Office: Entod Pharmaceuticals Ltd., OPHTHALMIC FORMULATIONS R & D OPHTHALMIC SPECIALTY EXCIPIENTS Ashirwad Building, S.V. Road, Opp. Badi Masjid, Bandra(W), Mumbai-400050, INDIA Email: [email protected] Additional Office: 15 Tottenham Lane, London N8 9DJ, UK. E-mail: [email protected] A Global Research-Based Speciality Website: ophthalmicsuk.com Formulation R&D: Pharmaceutical Enterprise Medisearch Laboratory entodinternational.com ENTOD HOUSE, W-50(B), M.I.D.C, T.T.C. Indl. Estate, Rabale, Thane-Belapur Road, Follow us on: Navi Mumbai-400701, INDIA Email: [email protected] @entodinternational @entodpharma Entod Pharmaceuticals Medisearch Laboratories Entod Research 2018073 Ltd. (India) (Bombay) Pvt. Ltd. (India) Cell Ltd. (UK) entodinternational.com entodinternational.com Complete Ophthalmic Finished Products Range PRESS-DT TABLET OMEFLOX-BM EYE DROPS EYETAMIN CAPSULES MYOPIA CONTROL Acetazolamide IP 250mg Ofloxacin IP 0.3% w/w Lycopene, Lutein Zeaxanthin, Betamethasone Sodium Phosphate 0.1% w/w Vitamins & Minerals MYATRO EYE DROPS ENDOR EYE DROPS FLUCOCID EYE DROPS Fluconazole USP 0.3% w/v Atropine Sulphate USP 0.01% w/v Dorzolamide HCl USP 2% w/v TOBRACID-F EYE DROPS I-DEW MEGA CAPSULES Stabilized Oxychloro Complex 0.005% w/v Benzalkonium Chloride Solution IP 0.0075%w/v NATACIN EYE DROPS Tobramycin Sulphate USP Omega 3 fatty acid (deodourised) eqv. To ENDOR PLUS EYE DROPS Natamycin USP 5.0%w/v equi. -
Secretariat GENERAL
UNITED NATIONS ST Distr. Secretariat GENERAL ST/SG/AC.10/C.3/2002/33 12 April 2002 ORIGINAL : ENGLISH COMMITTEE OF EXPERTS ON THE TRANSPORT OF DANGEROUS GOODS AND ON THE GLOBALLY HARMONIZED SYSTEM OF CLASSIFICATION AND LABELLING OF CHEMICALS Sub-Committee of Experts on the Transport of Dangerous Goods (Twenty-first session, 1-10 July 2002 agenda item 4) TRANSPORT OF SOLID SUBSTANCES IN BULK IN CONTAINERS Transport of solids in portable tanks Transmitted by the expert from the United States of America 1. At the twentieth session of the Sub-Committee, the expert from the United States of America agreed to coordinate the development of requirements for the transport of solid dangerous goods in portable tanks and to lead a correspondence group to review proposed requirements and develop a proposal for submission to the twenty-first session. Many solids are not currently authorized for transport in portable tanks in the Model Regulations. Consignors that transport solid dangerous goods are required to acquire competent authority approvals to transport their solids in tanks which imposes unnecessary burdens and delays. Adoption of this proposal will result in the assignment of tank codes for the majority of solids dangerous goods listed in the Dangerous Goods List that are suitable and safe for transport in portable tanks. In developing the assignments, a rationalized approach was developed (see Annex 1) and other regulations that provide portable tank requirements for solids were considered (e.g. IMDG Code, ADR/RID and 49 CFR). Annex 2 of this paper provides proposed assignments that are based on the rationalized approach that is provided in Annex 1. -
Food and Drugs
21 Part 170 to 199 Revised as of April 1, 2001 Food and Drugs Containing a codification of documents of general applicability and future effect As of April 1, 2001 With Ancillaries Published by Office of the Federal Register National Archives and Records Administration A Special Edition of the Federal Register VerDate 11<MAY>2000 11:38 Apr 16, 2001 Jkt 194064 PO 00000 Frm 00001 Fmt 8091 Sfmt 8091 Y:\SGML\194064F.XXX pfrm02 PsN: 194064F U.S. GOVERNMENT PRINTING OFFICE WASHINGTON : 2001 For sale by the Superintendent of Documents, U.S. Government Printing Office Internet: bookstore.gpo.gov Phone: (202) 512-1800 Tax: (202) 512-2250 Mail Stop: SSOP, Washington, DC 20402–0001 VerDate 11<MAY>2000 11:38 Apr 16, 2001 Jkt 194064 PO 00000 Frm 00002 Fmt 8092 Sfmt 8092 Y:\SGML\194064F.XXX pfrm02 PsN: 194064F Table of Contents Page Explanation ................................................................................................ v Title 21: Chapter I—Food and Drug Administration, Department of Health and Human Services (Continued) ................................................. 3 Finding Aids: Material Approved for Incorporation by Reference ............................ 573 Table of CFR Titles and Chapters ....................................................... 587 Alphabetical List of Agencies Appearing in the CFR ......................... 605 Redesignation Table ............................................................................ 615 List of CFR Sections Affected ............................................................. 617 -
Managing Discoloured Non-Vital Teeth: the Inside/Outside Bleaching Technique
RESTORATIVERESTORATIVE DENTISTRY DENTISTRY Managing Discoloured Non-Vital Teeth: The Inside/Outside Bleaching Technique NEIL J. POYSER, M ARTIN G.D. KELLEHER AND PETER F.A. BRIGGS Abstract: should be supported by appropriate The discoloured, non-vital anterior tooth is a common aesthetic concern for special investigations. A methodical many patients. It can have a profound effect on their self-esteem, interaction with approach will ensure that the chance of others and employability. Discoloured non-vital teeth are frequently compromised failure is reduced and that any owing to previous trauma, caries, endodontic therapy and failed restorations. Destructive invasive treatment options are likely to weaken the residual structure of consequence of possible failure is the tooth. This can reduce the prognosis and challenge the long-term viability of the minimal. Ideally, the treatment option tooth, thereby initiating further prosthetic predicaments. This paper discusses modern chosen should provide a predictable approaches to the treatment of discoloured teeth. The importance of preventing and result and be the most beneficial and eliminating the potential for discoloration will be highlighted. The paper will include a cost-effective one for the individual detailed technical account on the application of the inside/outside bleaching technique, patient. with several clinical examples. The most common cause of discoloration in non-vital teeth is the Dent Update 2004; 31: 204–214 presence of pulpal haemorrhagic Clinical Relevance: The inside/outside bleaching technique offers multiple products. The discoloration seen is benefits to patients and practitioners when considering the options for a discoloured thought to be due to the accumulation non-vital tooth. -
European Patent Office
Europäisches Patentamt *EP001047406B1* (19) European Patent Office Office européen des brevets (11) EP 1 047 406 B1 (12) EUROPEAN PATENT SPECIFICATION (45) Date of publication and mention (51) Int Cl.7: A61K 9/00, A61K 47/18 of the grant of the patent: 23.04.2003 Bulletin 2003/17 (86) International application number: PCT/EP99/00160 (21) Application number: 99906123.7 (87) International publication number: (22) Date of filing: 13.01.1999 WO 99/036055 (22.07.1999 Gazette 1999/29) (54) AUTOCLAVABLE PHARMACEUTICAL COMPOSITIONS CONTAINING A CHELATING AGENT AUTOKLAVIERBARE PHARMAZEUTISCHE ZUSAMMENSETZUNGEN MIT KOMPLEXBILDNER COMPOSITIONS PHARMACEUTIQUES AUTOCLAVABLES, CONTENANT UN CHELATEUR (84) Designated Contracting States: (72) Inventor: KIS, György, Lajos AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU CH-8273 Triboltingen (CH) MC NL PT SE (74) Representative: Becker, Konrad et al (30) Priority: 15.01.1998 EP 98810016 Novartis AG Corporate Intellectual Property (43) Date of publication of application: Patent- und Markenabteilung 02.11.2000 Bulletin 2000/44 4002 Basel (CH) (60) Divisional application: (56) References cited: 01124282.3 / 1 172 098 EP-A- 0 258 865 EP-A- 0 719 545 WO-A-97/00669 GB-A- 1 399 834 (73) Proprietors: GB-A- 2 001 529 US-A- 5 165 918 • Novartis AG 4056 Basel (CH) Designated Contracting States: BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE CY LI • Novartis Pharma GmbH 1230 Wien (AT) Designated Contracting States: AT Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. -
2020 Emergency Response Guidebook
2020 A guidebook intended for use by first responders A guidebook intended for use by first responders during the initial phase of a transportation incident during the initial phase of a transportation incident involving hazardous materials/dangerous goods involving hazardous materials/dangerous goods EMERGENCY RESPONSE GUIDEBOOK THIS DOCUMENT SHOULD NOT BE USED TO DETERMINE COMPLIANCE WITH THE HAZARDOUS MATERIALS/ DANGEROUS GOODS REGULATIONS OR 2020 TO CREATE WORKER SAFETY DOCUMENTS EMERGENCY RESPONSE FOR SPECIFIC CHEMICALS GUIDEBOOK NOT FOR SALE This document is intended for distribution free of charge to Public Safety Organizations by the US Department of Transportation and Transport Canada. This copy may not be resold by commercial distributors. https://www.phmsa.dot.gov/hazmat https://www.tc.gc.ca/TDG http://www.sct.gob.mx SHIPPING PAPERS (DOCUMENTS) 24-HOUR EMERGENCY RESPONSE TELEPHONE NUMBERS For the purpose of this guidebook, shipping documents and shipping papers are synonymous. CANADA Shipping papers provide vital information regarding the hazardous materials/dangerous goods to 1. CANUTEC initiate protective actions. A consolidated version of the information found on shipping papers may 1-888-CANUTEC (226-8832) or 613-996-6666 * be found as follows: *666 (STAR 666) cellular (in Canada only) • Road – kept in the cab of a motor vehicle • Rail – kept in possession of a crew member UNITED STATES • Aviation – kept in possession of the pilot or aircraft employees • Marine – kept in a holder on the bridge of a vessel 1. CHEMTREC 1-800-424-9300 Information provided: (in the U.S., Canada and the U.S. Virgin Islands) • 4-digit identification number, UN or NA (go to yellow pages) For calls originating elsewhere: 703-527-3887 * • Proper shipping name (go to blue pages) • Hazard class or division number of material 2. -
Usage Ingredients Literature
Usage Brush at least 2 times a day for at least 2 minutes with Implaclean®. Suitable for adults and children 6 years and over. Ingredients The toothpaste for people with dental implants Glycerin, Aqua, Hydrated Silica, Silica, PEG-32, Aroma, Cocamidopropyl Betaine, Sodium Gluconate, Cellulose Gum, Sodium Citrate, Lactoferrin, Sodium Saccharin, Magnesium Sulfate, Sodium Methylparaben, Sodium Perborate, Citric Acid, Sodium Chloride, Sodium Fluoride (200 ppm F-), CI 42090. Patented formula. Developed and recommended by dental surgeons, implantologists, dentists and oral hygienists. Literature 1. Berendsen JLM, el Allati I, Sylva LH, Blijdorp PA, Van Damme PhA, Meijer GJ. Ardox- X® adjunctive topical active oxygen application in periodontitis and peri-implantitis – a non published pilot study 2. Boere G Academic Centre for Dentistry Amsterdam (ACTA), Department of Dental Materials Science, The Netherlands, Influence of fluoride on titanium in an acidic environment measured by polarization resistance technique. J Appl Biomater. 1995 Winter;6(4):283-8 3. Nakagawa M, Matsuya S, Shiraishi T, Ohta M., Department of Dental Materials Engineering, Faculty of Dentistry, Kyushu University, Fukuoka, Japan. Effect of fluo- ride concentration and pH on corrosion behavior of titanium for dental use. J Dent Res. 1999 Sep;78(9):1568-72 4. Toumelin-Chemla F, Rouelle F, Burdairon G, Laboratoire de Biomatériaux, Faculté de Chirurgie Dentaire, l’Université Paris V, France Corrosive properties of fluoride- containing odontologic gels against titanium. J Dent. 1996 Jan-Mar;24(1-2):109-15. 5. Ide K, Hattori M, Yoshinari M, Kawada E, Oda Y. , Department of Dental Materials Science, Tokyo Dental College, 1-2-2 Masago, Mihama-ku, Chiba, Japan 261-8502. -
Korea Industrial Tariff Schedule
DRAFT Subject to Legal Review for Accuracy, Clarity, and Consistency Annex 2-B Industrial Schedule for the Republic of Korea Staging HSK 10 Description Base Rate Category 0301101000 Gold carp 10 C 0301102000 Tropical fish 10 C 0301109000 Other 10 A 0301911000 Salmo trutta, Oncorhynchus mykiss,Oncorhynchus clarki, Oncorhynchus 10 C aguabonita,Oncorhynchus gilae 0301912000 Oncorhynchus apache and Oncorhynchus chrysogaster 10 C 0301921000 Glass eel 10 A 0301929000 Other 30% or I ₩1,908/kg 0301930000 Carp 10 C 0301992000 Yellow tail 10 A 0301994000 Sea-bream 45% or G ₩3,292/kg 0301995000 Conger eel 10 G 0301996000 Sharp toothed eel 10 G 0301997000 Salad eel 10 C 0301998000 Flat fish 10 C 0301999010 True bass 10 G 0301999020 Puffers 10 G 0301999030 Tilapia 10 C 0301999040 Rock fish(including pacific ocean perch) 10 C 0301999050 Sea bass 40 C 0301999060 Mullets 10 C 0301999070 Loaches 10 C 0301999080 Cat fishes 10 A 0301999091 Rock Trout(Hexagrammos spp., Agrammus spp.) 10 C 0301999092 Crusian carp 10 C 0301999093 Salmon 10 A 0301999094 Grass carp 10 A 0301999095 Croakers 36 G 0301999099 Other 10 G 0302111000 Salmo trutta, Oncorhynchus mykiss, Oncorhynchus clarki,Oncorhynchus 20 G aquabonita, Oncorhynchus gilae 0302112000 Oncorhynchus apache and Oncorhynchus chrysogaster 20 A 0302120000 Pacific salmon(Oncorhynchus nerka, Oncorhynchus gorbuscha, Oncorhynchus 20 A keta, Oncorhynchus tschawytscha, Oncorhynchus kisutch, Oncorhynchus masou and Oncorhynchus rhodurus), Atlantic salmon(Salmo salar)and Danube salmon(Hucho hucho) 0302190000 Other 20