Authors: Pallavi Subhraveti Ron Caspi Peter Midford Peter D Karp An online version of this diagram is available at BioCyc.org. Biosynthetic pathways are positioned in the left of the cytoplasm, degradative pathways on the right, and reactions not assigned to any pathway are in the far right of the cytoplasm. Transporters and membrane proteins are shown on the membrane. Ingrid Keseler Periplasmic (where appropriate) and extracellular reactions and proteins may also be shown. Pathways are colored according to their cellular function. Gcf_004006635Cyc: Fusobacterium necrophorum necrophorum ATCC 25286 Cellular Overview Connections between pathways are omitted for legibility. Anamika Kothari

Macromolecule Modification , Prosthetic Group, Electron Carrier, and Vitamin Biosynthesis Amino Acid Degradation Aldehyde Carbohydrate Biosynthesis Degradation core a peptidoglycan 5'-chloro-5'- UDP-N-acetyl- tRNA processing L- degradation III cob(II)alamin- M-antigen a nucleoside a ribonucleoside L,L- cob(II)yrinate a,c- L-threonine D-serine methylmalonyl- a purine oligosaccharide- glycerophosphoserine a ribonucleic acid a purine α-D-glucosamine oxaloacetate a malonyl-[acp] cob(II)yrinate a,c-diamide flavin biosynthesis I (bacteria and plants) adenosylcobinamide-GDP adenosylcobalamin tetrahydrofolate biosynthesis 10 glutathione- methylglyoxal ATP [CblC-CblD ATP cob(II)inamide dimer with triphosphate deoxyadenosine diphosphate diamide biosynthesis I adenosylcobinamide- N -formyl-tetrahydrofolate biosynthesis di-trans,poly-cis O-antigen building blocks biosynthesis (E. coli) degradation I degradation CoA mutase ribonucleoside adenosylcobinamide (variant) monomer glycerophosphodiester ribonucleoside purine-nucleoside UDP-N- diaminopimelate oxaloacetate biosynthesis II (late salvage from cobinamide I salvage from cobalamin glutaredoxin ADP-L-glycero-β- UDP-α-D-galactose degradation I complex] lipid A (E. coli pentapeptide DNA-directed ribonucleotide- diaminopimelate beta- (early cobalt insertion) GDP biosynthesis from (7,8-dihydropterin- -undecaprenyl a polycistronic cob(I)yrinic acid cob(I)yrinic acid a,c-diamide 5'-triphosphate bifunctional undecaprenyl phosphodiesterase: purine-nucleoside phosphorylase: acetylglucosamine decarboxylase: cobalt incorporation) α α biosynthesis his K-12 core type) stems (meso- RNA polymerase diphosphate epimerase: ketoacyl- cobyrinate a,c-diamide redox reactions phosphate biosynthesis UDP- -D- -D- D-glucopyranose D-manno-heptose tRNA precursor adenosyltransferase: diphosphate O-antigen phosphorylase: 2-epimerase (non- uroporphyrinogen-III GTP cob(II)inamide cob(I)alamin 6-yl)methyl 4-aminobenzoate a tetrahydrofolate thr D-serine methylglyoxal a,c-diamide adenosylcobinamide (no GlcNAc) diaminopimelateN-acetylmuramoyl- EO219_RS06925 deoD reductase: EO219_RS11900 EO219_RS06990 uroporphyrinogen-III cob(II)yrinate (2E,6E)-farnesyl galactose glucopyranose 6-phosphate biosynthesis subunit alpha: deoD [acyl- uroporphyrinogen-III cob(I)yrinic acid diphosphate glutathione IPP glucose-6- UDP-α-D-glucose histidine ammonia- lactoylglutathione adenosyltransferase: EO219_RS00500 kinase/ domain- containing)L-alanine amidase: glycerophosphodiester purine-nucleoside EO219_RS00225 hydrolyzing): oxaloacetate uroporphyrinogen-III a,c-diamide diphosphate 1-phosphate D-sedoheptulose threonine D-serine L-methionine EO219_RS01280 diaminopimelate carrier- C-methyltransferase: cob(I)yrinic acid a,c-diamide 7,8- glucose-1-phosphate phosphate UDP-glucose : hutH lyase: EO219_RS07480 cob(I)yrinic acid a,c-diamide adenosylcobinamide- containing protein: EO219_RS01050 phosphodiesterase: purine-nucleoside phosphorylase: EO219_RS00230 EO219_RS04535 decarboxylase C-methyltransferase: bifunctional UDP-Galf 7-phosphateD-sedoheptulose ammonia-lyase: ammonia- degradation II DNA- a 2'- epimerase: protein] cobA a,c-diamide adenosyltransferase: dihydropteroate 5-methyltetrahydrofolate- di-trans,octa-cis thymidylyltransferase: : 4-epimerase EO219_RS08920 cob(I)yrinic acid adenosyltransferase: phosphate EO219_RS04680 N-acetylmuramoyl- EO219_RS00215 phosphorylase: deoD UDP-N- subunit alpha: cobA 3,4-dihydroxy- cob(II)alamin histidine ammonia- (2Z)-2-aminobut-EO219_RS11680 lyase: (R)-S- directed RNA deoxyribonucleoside EO219_RS01660 synthase adenosyltransferase: -homocysteine a reduced -undecaprenyl rfbA 7-phosphate GalE: galE a tRNA precursor a tRNA precursor EO219_RS07480 guanylyltransferase: a peptidoglycan deoD 5-chloro-5- precorrin-1 precorrin-1 2-butanone- EO219_RS07480 bifunctional dTDP-α-D-glucose EO219_RS01795 lyase: hutH dsdA a,c-diamide O-antigen L-alanine amidase: sn-glycerol α-D-ribose- 5'-diphosphate acetylglucosamine meso- EO219_RS06985 II: fabF EO219_RS07480 methyltransferase: glutaredoxin isomerase: gmhA with a 5' with a 5' 2-enoate 2-aminoprop- met lactoylglutathione EO219_RS04435 L-alanyl-γ-D- dimer with ser polymerase: adenine a 3- cob(I)yrinic acid cob(I)yrinic acid folylpolyglutamate diphosphate F6P D-glycero-D- [+ 2 isozymes] adenosyltransferase: triphosphate adenosylcobinamide a purine adenosyl- ligase domain- EO219_RS02760 3-phosphate a purine base deoxyribose 2-epimerase (non- diaminopimelate pyruvate uroporphyrinogen-III 4-phosphate EO219_RS10045 dTDP-glucose α extension and extension and a 2-enoate methionine glutamyl-meso-2,6- pentapeptide rpoB 1-phosphate oxodocosanoyl- uroporphyrinogen-III cob(I)yrinic acid a,c-diamide a,c-diamide synthase/ glutaredoxin: undecaprenyl- manno-heptose UDP- -D-galactose urocanate a [cobalamin EO219_RS00500 adenosylcobalamin- ribonucleoside cobinamide containing protein: 1-phosphate hydrolyzing): C-methyltransferase: synthase/GTP 4,6-dehydratase: glutamine-- a long 3' trailer short 3' extension gamma- a [cyanocobalamin di-trans,octa-cis diaminopimeloyl- stem (meso- rpoC rpoZ [acp] C-methyltransferase: a,c-diamide adenosyltransferase: adenosyltransferase: dihydrofolate dihydrofolate EO219_RS08930 diphosphate 7-phosphate trafficking triphosphate [methylmalonyl- 5'-diphosphate phosphate EO219_RS10720 EO219_RS04775 cobA cyclohydrolase II: EO219_RS04585 fructose-6- D-glycero- ribonuclease urocanate hydratase: lyase: megL reductase CblC] -undecaprenyl E. coli M D-alanyl-D-alanine diaminopimelate a ribonucleic acid UDP-N-acetyl-α- cobA adenosyltransferase: EO219_RS00500 EO219_RS07480 synthase: reductase: glutaredoxin: phosphatase: (2Z)-2-aminobut- protein CblD] CoA mutase] LPS EO219_RS00180 [corrinoid dTDP-4-dehydro- phosphate beta-D- P protein EO219_RS01980 2-iminobutanoate (R)-lactate diphosphate containing) D-mannosamine precorrin-2 2,5-diamino-6- cob(II)yrinate a,cEO219_RS00500- cob(I)yrinic acid EO219_RS00835 EO219_RS01265 EO219_RS00235 EO219_RS05230 2-enoate precorrin-2 adenosyltranferase]- serine 6-deoxy-α-D- transaminase manno- ribonuclease component: urocanate hydratase: 2-iminopropanoate (5-phospho-D- diamide-[corrinoid a,c-diamide a protein with di-trans,octa-cis- cob(II)inamide 7,8-dihydrofolate a 7,8-dihydrofolate hydroxymethyltransferase: a 5-methyltetrahydrofolate glucopyranose (isomerizing) heptose-7- PRPP biosynthesis PH: rph rnpA EO219_RS02835 ribosylamino) adenosyltranferase] reduced L- undecaprenyl phosphate UDP-N-acetyl- UDP-N-acetyl- N-acetyl-α- 2251 precorrin-2 C(20)- adenosyltransferase: monoglutamate EO219_RS07260 a tRNA precursor cob(II)alamin- an apo-["base- guanosine an L-cysteinyl- a negatively cysteine residues dTDP-4- : glmS phosphate cob(II)yrinate α glycerophosphoglycerol α a purine 2'- D-muramoyl- 5-MTR-1-P methyltransferase: pyrimidin- EO219_RS00500 D-ribose 5- a tRNA 4-imidazolone-5-propanoate ATP [CblC-CblD off/His-on" ATP cob(II)alamin ATP -D-muramoyl- di-trans,octa-cis -D-muramoyl- di-trans,octa-cis in 23S rRNA Cys supercoiled DNA dITP dehydrorhamnose D-glucosamine kinase: rfaE1 with a short hypoxanthine PRPP a,c-diamide deoxyribonucleoside [tRNA ] type I DNA cobI 4(3H)-one cob(II)alamin- β phosphate 2-oxobutanoate 2-iminobutanoate pyruvate L-alanyl-γ-D- -undecaprenyl glycerophosphodiester L-alanyl-γ-D- -undecaprenyl L-alanine(1-)N-acetylmuramoyl- 23S rRNA aminoacyl-tRNA S-methyl-5- [corrinoid thymidylate 3,5-epimerase: rfbC 6-phosphate D-glycero- -D- ribose-phosphate precursor with 3' extension L-histidine degradation I complex] B12-] hypoxanthine purine-nucleoside sirohydrochlorin bifunctional [corrinoid imidazolonepropionase: hutI pyruvate cob(I)yrinic acid cob(I)yrinic acid a,c-diamide cob(I)yrinic acid glutamyl-L-lysyl- phosphate phosphodiesterase: glutamyl-L- phospho-N-phosphate L-alanine amidase: (guanosine(2251) : thioribose-1- topoisomerase: XTP/dITP cob(I)yrinate a,c- adenosyltranferase]- synthase: manno-heptose diphosphokinase: a 5' extension phosphoribosyltransferase: hpt phospho-N- phosphorylase: precorrin-3A diaminohydroxyphosphoribosylaminopyrimidine adenosyltranferase] dTDP-4-dehydro- phosphoglucosamine imidazolonepropionase: a,c-diamide adenosyltransferase: a,c-diamide D-alanyl-D-alanine EO219_RS00215 lysyl-D-alanine -2'-O)- phosphate topA diamide-[corrinoid cob(I)inamide a 7,8-dihydrofolate thyA β 1,7-bisphosphate ribonuclease acetylmuramoyl- acetylmuramoyl- EO219_RS01050 EO219_RS01910 diphosphatase: deaminase/5-amino-6-(5-phosphoribosylamino) bifunctional 5,10- 4-aminobenzoate -L-rhamnose mutase: EO219_RS03825 EO219_RS05060 adenosyltransferase: EO219_RS07480 xanthine adenosyltransferase: deoD methyltransferase isomerase: DNA adenosyltranferase] a (6S)-5- D-glycero-beta-D- PRPP PH: rph his undecaprenyl-pentapeptide- glycerophosphodiester undecaprenyl-pentapeptide- N-acetylmuramoyl- aminoacyl-tRNA EO219_RS09625 uracil reductase RibD: ribD cob(I)yrinic acid methylenetetrahydrofolate biosynthesis dTDP-4- EO219_RS03335 EO219_RS07480 cob(I)yrinic acid a,c-diamide phosphoribosyltransferase: EO219_RS00500 purine-nucleoside RlmB: rlmB EO219_RS08410 topoisomerase cob(I)yrinic acid dihydrofolate formyltetrahydrofolate manno-heptose diphospho-:N- mraY phosphodiesterase: diphospho-transferase:N- mraY L-alanine amidase: 2-O- hydrolase: 5-(methylsulfanyl) 5-amino-6-(5- a,c-diamide dehydrogenase/5,10- dehydrorhamnose α histidine 2-oxobutanoate EO219_RS09005 phosphorylase: cobalt- -D-glucosamine N-formimino-L-glutamate propanoyl-CoA cob(I)yrinic acid adenosyltransferase: cob(I)yrinic acid EO219_RS06925 2251 III: topB dIMP a,c-diamide adenosyltransferase: cob(I)alamin- reductase: methenyltetrahydrofolate chorismate 1,7-bisphosphate ammonia- acetylmuramoyl- acetylmuramoyl- EO219_RS02760 methylguanosine EO219_RS10100 -ribulose 1- sirohydrochlorin phospho-D- reductase: rfbD 1-phosphate a,c-diamide EO219_RS00500 IMP a,c-diamide UMP sn-glycerol UMP 2-deoxy-α- deoD N-acetyl-D- adenosyltransferase: [corrinoid EO219_RS01265 7-phosphatase: L-alanyl-γ-D- glycerol L-alanyl-γ-D- in 23S rRNA Cys phosphate a relaxed DNA precorrin-3B D-ribulose ribosylamino)uracil EO219_RS07480 cyclohydrolase: aminodeoxychorismate dTDP-β-L- lyase: hutH triphosphate adenosylcobalamin 3-phosphate D-ribose 1- a purine base ala muramate a tRNA cys EO219_RS07480 adenosyltranferase] bifunctional UDP-N- EO219_RS02245 an uncharged adenosyltransferase: adenosyltransferase: glutamyl-L-lysyl- glutamyl-L- 5-phosphate bifunctional cob(I)yrinic acid a tetrahydrofolate a 5,10- EO219_RS12140 a 5,10- synthase rhamnose glutamate histidine precorrin-3B C(17)- cob(I)yrinic acid acetylglucosamine D-glycero-β-D- tRNA a [cobalamin EO219_RS00500 a holo-["base- EO219_RS07480 D-alanyl-D-alanine lysyl- D-alanine phosphate diaminohydroxyphosphoribosylaminopyrimidine cob(I)yrinic acid a,c-diamide methylenetetrahydrofolate methenyltetrahydrofolate component I: pabB formimidoyltransferase: ftcD ammonia- a [cyanocobalamin adenosyl-cob(III) methyltransferase: bifunctional a,c-diamide 4-amino-4- diphosphorylase/ manno-heptose propanoyl trafficking triphosphate off/His-on" triphosphate deaminase/5-amino-6-(5-phosphoribosylamino) a,c-diamide adenosyltransferase: glutamate lyase: hutH L-serine degradation reductase CblC] yrinate a,c-diamide cobalt-factor III cobJ 3,4-dihydroxy- adenosyltransferase: bifunctional 5,10- deoxychorismate glucosamine-1- 1-phosphate phosphate protein CblD] B12-enzyme] uracil reductase RibD: ribD adenosyltransferase: EO219_RS00500 formimidoyltransferase: ftcD urocanate 2-butanone- 5-amino-6-(5- EO219_RS07480 methylenetetrahydrofolate 4-amino-4- phosphate N- D-glycero-beta-D- precorrin-4 EO219_RS00500 dehydrogenase/5,10- acetate kinase: 4-phosphate phospho-D- deoxychorismate acetyltransferase manno-heptose urocanate ser (R)-4'- an sn-glycero-3- sn-glycero-3- a 1-acyl-2- 1-myristoyl- adenosyl-cob(III) adenosylcobinamide cob(I)yrinic acid lipoprotein posttranslational EO219_RS12020 a peptidoglycan 1-myristoyl- a double-stranded an L-asparaginyl- sn-glycerol synthase/GTP methenyltetrahydrofolate lyase: GlmU: glmU 1-phosphate a 5-formiminotetrahydrofolate hydratase: L-serine 16-hydroxypalmitate phosphopantothenoyl- phospho-N-(acyl) adenosylcobinamide an apo [peptidyl- sn-glycerol precorrin-4 C(11)- ribitylamino)uracil a,c-diamide glu phospho-N- a palmitoleoyl-[acp] sn-glycerol arachidonoyl- coenzyme A oligonucleotide Asn cyclohydrolase II: yrinate a,c-diamide cyclohydrolase: EO219_RS03210 modification CTP carrier protein] [tRNA ] 3-phosphate XTP methyltransferase: bifunctional adenosyltransferase: N-acetyl-α-D- adenylyltransferase: EO219_RS01980 ammonia-lyase: N-acetylmuramoyl- long-chain fatty L-cysteine ethanolamine (arachidonoyl) 3-phosphate sn-glycerol bifunctional bifunctional 3-phosphate glycerol-3- cobalt-precorrin-3 cobyric acid EO219_RS12140 formimidoyltetrahydrofolate propanoate bifunctional glycerophosphodiester 1-acyl-sn-glycerol- holo-[acyl- aminoacyl-tRNA 1-acyl-sn-glycerol- cobM EO219_RS00180 adenosylcobinamide EO219_RS00500 glucosamine rfaE2 a [prolipoprotein]- urocanate EO219_RS10415 L-alanine amidase: acid--CoA ligase: ethanolamineglycerophosphodiester 3-phosphatephosphatidate adenosylcobinamide oligoribonuclease/ phosphate 1-O- synthase: 4-aminobenzoate cyclodeaminase: 2-aminoprop- phosphopantothenoylcysteine phosphodiesterase: 3-phosphate carrier- hydrolase: 3-phosphate XTP/dITP 1-deoxy-L- kinase/ adenosylcob(III) a 10- 1-phosphate ADP-D-glycero-β- L-cysteine hydratase: EO219_RS01050 EO219_RS10160 phosphodiesterase: cytidylyltransferase: kinase/ PAP phosphatase acyltransferase: EO219_RS03530 superpathway of thiamine diphosphate biosynthesis I EO219_RS02855 2-enoate decarboxylase/ EO219_RS06925 acyltransferase: protein] EO219_RS01910 acyltransferase: diphosphatase: precorrin-5 glycero-tetrulose ARP adenosylcobinamide- alamin-[corrinoid formyltetrahydrofolate bifunctional UDP-N- D-manno-heptose prolipoprotein EO219_RS02835 N-acetylmuramoyl- [+ 2 isozymes] EO219_RS00215 EO219_RS06785 adenosylcobinamide- NrnA: plsY 4-phosphate phosphopantothenate-- glycerophosphodiester EO219_RS067801-myristoyl-2- synthase: aminoacyl-tRNA 1-myristoyl-2-EO219_RS06780 1-(18- EO219_RS09625 cobyric acid phosphate adenosyltranferase] acetylglucosamine ADP- diacylglyceryl formimidoyltetrahydrofolate 4-imidazolone- L-alanine amidase: phosphatidate phosphate EO219_RS03485 NAD de novo 16-hydroxypalmitoyl- cysteine ligase CoaBC: coaBC phosphodiesterase: glycerophosphodiester palmitoleoyl- acpS hydrolase: palmitoleoyl- hydroxyoleoyl) synthase: guanylyltransferase: cob(I)yrinic acid cys diphosphorylase/ glyceromanno- transferase: lgt cyclodeaminase: L-glutamine 5-propanoate EO219_RS02760 AMP diphosphate acyl-carrier protein cytidylyltransferase: guanylyltransferase: a holo [peptidyl- a nucleoside 5'- XMP cobalt-precorrin-4 6,7-dimethyl-8- biosynthesis I a [prolipoprotein]- ditrans,octacis- CoA 4'-phosphopantetheine EO219_RS00215 phosphodiesterase: sn-glycerol 3',5'-ADP EO219_RS10100 sn-glycerol -sn-glycrol EO219_RS06675 EO219_RS04435 a,c-diamide glucosamine-1- heptose 6- EO219_RS05065 degradation II sn-glycerol an N- a CDP-1-acyl-EO219_RS00990 EO219_RS04435 carrier protein] monophosphate (from aspartate) imidazolonepropionase: hutI 2-iminopropanoate EO219_RS06925 Asn 3-phosphate 3-phosphate ribityllumazine (R)-1-amino- cysteine acyl carrier S-1,2-diacyl-sn- a peptidoglycan undecaprenyldiphospho- sn-glycerol 3-phosphate adenosyl-cobinamide tRNA asn precorrin-6A adenosyl-cobinamide adenosyltransferase: phosphate N- epimerase: rfaD a 5,10-methenyltetrahydrofolate imidazolonepropionase: 3-phosphate acylethanolamine anandamide 2-arachidonoyl- synthase: 2-propanol O adenosylcobyrate desulfurase protein β glyceryl-L-cysteine pentapeptide N-acetyl-(N- 3-phosphate asp phosphate EO219_RS07480 acetyltransferase ADP-L-glycero- - gln EO219_RS05060 glycerol phosphate EO219_RS00195 -2-phosphate a ThiS sulfur- NifS: nifS activation acetylglucosaminyl)muramate precorrin-6A cob(I)yrinic acid GlmU: glmU D-manno-heptose bifunctional 5,10- NADPH- cobalt- cobalamin bifunctional carrier protein an [L-cysteine an apo acyl- signal N-formimino- reductase: a,c-diamide UDP-N-acetyl- methylenetetrahydrofolate dependent precorrin-5A 6,7-dimethyl-8-(1- biosynthesis adenosylcobinamide desulfurase]-S- carrier protein peptidase L-glutamate cobK 2-iminosuccinate adenosyltransferase: D-glyceraldehyde sulfur carrier holo-[acyl- α-D-glucosamine dehydrogenase/5,10- glutamate pyruvate L-asparagine an inactive (2E)- sn-glycero-3- a (2R)-2-hydroxy 1-palmitoyl- an apo-[LYS2 L- a uridine 38- a 1-acyl-sn (S)-4-amino-5- cobalt- D-ribityl)lumazine protein kinase/ sulfanyl-L-cysteine II: lspA 18-hydroxystearate a (6S)-5- an N-modified DHAP EO219_RS00500 3-phosphate protein ThiS carrier- methenyltetrahydrofolate synthase: degradation I ribonucleoside a reduced hexadecenoate phosphoethanolamine even numbered a palmitoleoyl-[acp] sn-glycerol glu 2-aminoadipyl- coenzyme A 40 in tRNA -glycerol 3- oxopentanoate precorrin 5A precorrin-6B riboflavin CobD: cobD adenosylcobinamide- formimidoylglutamase: SAM formyltetrahydrofolate aminoacyl-[tRNA] ITP adenosyl- adenylyltransferase protein] an (S-diacyl- cyclohydrolase: gltA triphosphate flavodoxin long-chain fatty long-chain-fatty- glycerophosphodiester straight chain 3-phosphate aminoacyl-tRNA carrier-protein] tRNA NAD(P)H- phosphate1-acyl-sn-glycerol- glutamate-1- hydrolase: synthase: phosphate 1-deoxy-D-xylulose- a lipoprotein hutG anaerobic 1-acyl-sn-glycerol- bifunctional holo-[acyl- cobinamide adenosylcobalamin ThiF: thiF synthase: sn-glyceryl) EO219_RS12140 glu reductase acid--CoA ligase: acid--CoA ligase: phosphodiesterase: 2,3,4-saturated hydrolase: pseudouridine(38- dependent glycerol- 3-phosphate semialdehyde- XTP/dITP cbiG precorrin-6y C5,15- ribE guanylyltransferase: 5-phosphate signal peptide asn ribonucleoside- long-chain fatty 3-phosphate folylpolyglutamate carrier- methyltransferase phosphate synthase: a carboxy- a [ThiI sulfur- acpS Metabolic Regulator -L-cysteinyl- EO219_RS10160 EO219_RS11235 EO219_RS06925 fatty acidacid--CoA ligase: acyltransferase: EO219_RS01910 protein] 40) synthase 3-phosphate acyltransferase: 2,1- diphosphatase: cobalt- EO219_RS04435 a holo acyl- a 10-formyltetrahydrofolate L-aspartate glu : triphosphate synthase/ (decarboxylating) riboflavin quinolinate bifunctional EO219_RS07710 adenylated-[ThiS carrier protein]-S- Biosynthesis [apolipoprotein] L-glutamine [+ 2 isozymes] [+ 2 isozymes] glycerophosphodiester EO219_RS10160 EO219_RS06780 synthase: TruA: truA dehydrogenase: EO219_RS06780 aminomutase: EO219_RS09625 precorrin-5B AIR tyr carrier protein degradation I EO219_RS08120 reductase a (R)-2-hydroxy 1-palmitoyl-2- dihydrofolate aminoacyl-tRNA a 1-acyl-2- : cbiE cbiT adenosylcobinamide adenosylcobinamide- sulfur-carrier protein] sulfanyl-L-cysteine degradation I 18-hydroxystearoyl- (2E)- phosphodiesterase: acpS [+ 3 isozymes] EO219_RS09770 hemL 1-deoxy-D- activating [+ 2even isozymes] numbered palmitoleoyl- synthase: hydrolase: a holo-[LYS2 L- a pseudouridine 38- arachidonoyl- bifunctional GDP ppGpp biosynthesis asp AMP diphosphate AMP diphosphate EO219_RS00215 acyl-carrier protein sn-glycerol 5-aminolevulinate IMP kinase/ phosphomethylpyrimidine xylulose-5- 2-iminoacetate asp an active CoA hexadecenoyl-CoA diphosphate AMP straight chain sn-glycerol EO219_RS00835 EO219_RS10100 2-aminoadipyl- 3',5'-ADP sn-glycerol precorrin-7 riboflavin kinase/ thiamine salvage II a peptide protein: nrdG sn-glycerol a (6S)-5- an N-modified an uncharged 40 in tRNA 3-phosphate adenosylcobinamide- synthase ThiC: thiC phosphate synthase an N-acyl-(S- gln a flavodoxin ribonucleoside ethanolamine 2,3,4-saturated 3-phosphate carrier-protein] 3-phosphate FAD synthetase: pyridoxal phosphate- met 5'-deoxyadenosine 3-phosphate formyltetrahydrofolate amino acid tRNA cobalt- phosphate synthase: dxs ThiH: thiH pppGpp semiquinone triphosphate fatty acyl CoA precorrin-6y C5,15- EO219_RS07460 NaMN 5-(2-hydroxyethyl) diacyl-sn-glyceryl) dependent precorrin-6A guanylyltransferase: HMP-P a thiocarboxy- A: glsA reductase methyltransferase 1-deoxy-D-xylulose -4-methylthiazole -L-cysteinyl- aminotransferase: nicotinate EO219_RS04435 2-iminoacetate [ThiS-Protein] [+ 4 isozymes] (decarboxylating) FMN bifunctional 5-phosphate 4-methyl-5(B- [lipoprotein] EO219_RS05220 (nicotinamide) 4-amino-2-methyl-5- bifunctional (p)ppGpp glu : cbiE cbiT adenosylcobinamide- hydroxymethylpyrimidine hydroxyethyl) oxaloacetate undecaprenyl- an odd numbered a 2,3,4-saturated 1-stearoyl- 1-stearoyl- DNA with adenine:7,8- 1-palmitoyl- a protein-L- bifunctional nucleotide pyrimidinemethanol synthetase/guanosine- a (6S)-5- (15Z)- α-D- [EntB aryl- a [release factor]- GDP kinase/ thiazole synthase: -thiazole glu straight chain CTP 1,2-diacyl-sn- dihydro-8- sn-glycerol L-threonine 3- methionine- cobalt- precorrin-8x riboflavin kinase/ adenylyltransferase: 3',5'-bis(diphosphate) 3'- diphospho-N- tetracosenoate a palmitoyl-[acp] sn-glycerol a stearoyl-[acp] sn-glycerol glucopyranose ATP coenzyme A L-glutamine phosphomethylpyrimidine EO219_RS10510 monophosphate bifunctional formyltetrahydrofolate long-chain-fatty- 2,3,4-saturated glycerol 3-phosphate carrier protein] peptide chain oxoguanine mismatch 3-phosphate O-phosphate (R)-S-oxide precorrin-6B FAD synthetase: nadD 2-methyladeninyl adenosylcobamide pyrophosphohydrolase: Alcohol Degradation acetylmuramoyl- UDP-N-acetyl- glutamate phosphatidate 1-acyl-sn-glycerol-3-phosphate 1-acyl-sn-glycerol-3-phosphate 1-phosphate holo-[acyl- A/G-specific 1-acyl-sn-glycerol- peptide- kinase: thiD biosynthesis hydroxymethylpyrimidine queuosine biosynthesis γ α acid--CoA ligase: fatty acidlong-chain fatty release factor threonine- precorrin-8X EO219_RS07460 biosynthesis from adenosylcobinamide-GDP 2-[(2R,5Z)-2-carboxy- EO219_RS12110 L-alanyl- -D- -D-glucosamine formimidoyltransferase: ftcD cytidylyltransferase: 3-phosphate 3-phosphate glucose-1-phosphate carrier- adenine 3-phosphate methionine nicotinate adenine protein: kinase/ glutamyl-L-lysyl- undecaprenyldiphospho- EO219_RS11235 acid--CoA ligase: adenylyltransferase N(5)-glutamine phosphate methylmutase: 4-methylthiazol-5(2H)- GTP pyrophosphokinase: glycerol and glycerophosphodiester degradation glutamate EO219_RS06785 acyltransferase: acyltransferase: protein] glycosylase: acyltransferase: (R)-S-oxide dinucleotide HMP-PP EO219_RS06805 phosphomethylpyrimidine preQ D-alanyl-D-alanine muramoylpentapeptide beta-N- [+ 2 isozymes] EO219_RS10160 subunit GlgD: glgD methyltransferase: decarboxylase: cbiC FAD 2-methyladenine ylidene]ethyl phosphate 0 formimidoyltransferase: ftcD phosphatidate EO219_RS06780 EO219_RS06780 synthase: mutY 1-palmitoyl-2-EO219_RS06780 reductase: kinase: thiD EO219_RS09055 NADPH-dependent 7- ditrans,octacisacetylglucosaminyltransferase:- [+an 2 isozymes]odd numbered 1-stearoyl- 1-stearoyl-2- prmC (R)-1-amino-EO219_RS03545 NAD+ synthase: N-formyl- (15Z)- glucose-1-phosphate acpS an apurinic site msrB cobalt-precorrin-7 hydrogenobyrinate 4-methyl-5(B- a glycerophosphodiester undecaprenyldiphospho-murG a tetrahydrofolate AMP diphosphate straight chain cytidylyltransferase: 2-palmitoyl- stearoyl-sn a [release factor]-N 5 adenine palmitoleoyl- 2-propanol O EO219_RS00350 nicotinate-nucleotide-- thiamine cyano-7-deazaguanine L-glutamate diphosphate AMP acyl-carrier protein acyl-carrier protein adenylyltransferase: a holo-[EntB aryl- a [protein]-L- hydroxyethyl) HMP-P N-acetyl-(N-acetyl-β-D- tetracosenoyl-CoA 2,3,4-saturated EO219_RS00990 sn-glycerol -glycerol 3- 3',5'-ADP -methyl-L-glutamine within DNA sn-glycerol -2-phosphate dimethylbenzimidazole phosphate reductase QueF: queF UDP a CDP-2,3,4-saturated- EO219_RS10005 carrier protein] methionine + -thiazole GTP ppGpp glucosaminyl)muramoyl- fatty acyl CoA 3-phosphate phosphate 3-phosphate NAD phosphoribosyltransferase: preQ Nucleoside and Nucleotide Degradation ADP-α-D-glucose synthase: thiE adeninyl adenosylcobamide biosynthesis monophosphate bifunctional 1 glycerophosphodiester L-alanyl-γ-D-glutamyl-L- diacylglycerol cobT from adenosylcobinamide-GDP biosynthesis hydroxymethylpyrimidine tRNA guanosine(34) phosphodiesterase: glycerol lysyl-D-alanyl-D-alanine hydrogenobyrinate cobalt-precorrin-8 phosphopantothenate biosynthesis I protein: kinase/ transglycosylase superpathway of purine deoxyribonucleosides degradation EO219_RS06925 a,c-diamide 2-methyladenine thiamine phosphate phosphomethylpyrimidine inosine 5'- EO219_RS07865 Tgt: EO219_RS12105 superpathway of pyrimidine glycerophosphodiester glycerol adenosylcobinamide- ribotide phosphate adenine kinase: thiD phosphate an N 6 -L- a 2-methyl 34 a 1-acyl-sn cobalt chelatase: benzimidazolyl adenosylcobamide 3-methyl-2- a 5,10- 4-methyl-5-(2- deoxyribonucleosides degradation phosphodiesterase: kinase: a sulfurated O-acetyl-L- adenosylcobinamide- phenyl ribotide a malonyl-[acp] linoleate a guanine a 5-aminomethyl-2- AsbD acyl- a 1,4-α-D-glucan a 1,4-α-D-glucan GTP pyrophosphokinase: a 7-aminomethyl-7- degradation 37 branched 2,3,4- queuine 34 H O acetyl-CoA -glycerol 3- EO219_RS09160 oxobutanoate methylenetetrahydrofolate GDP 2'-deoxyguanosine threonylcarbamoyladenine methanethiol GDP phosphate a malonyl-[acp] in tRNA thiouridine in tRNA coenzyme A 2 D-lysine biosynthesis from adenosylcobinamide-GDP phosphooxyethyl) HMP-PP bifunctional (p)ppGpp deazaguanosine 34 in tRNA EO219_RS00215 glpK [sulfur carrier] homoserine methyl ester carrier protein 1,4-alpha- 1,4-alpha- cobaltochelatase nicotinate-nucleotide-- EO219_RS09055 2'-deoxycytidine in tRNA tRNA (N(6)-L- O-acetylhomoserine adenosylcobinamide- beta-ketoacyl- saturated fattylong-chain acid fatty long-chain fatty tRNA guanosine(34) tRNA (5- holo-[acyl- acetyl-CoA D-lysine 5,6- phosphate1-acyl-sn-glycerol- cobyrinate 3-methyl-2-oxobutanoate thiazole synthetase/guanosine- tRNA preQ1(34) S- 2'-deoxyadenosine IMP acid--CoA ligase: transglycosylase methylaminomethyl- hydrolase/ glucan glucan subunit CobN: cobN benzimidazole hydroxymethyltransferase: adenosylcobinamide- dimethylbenzimidazole threonylcarbamoyladenosine(37) aminocarboxypropyltransferase/ GDP [acyl-carrier- acid--CoA ligase: carrier- aminomutase 3-phosphate thiamine diphosphate 3',5'-bis(diphosphate) 3'- adenosylmethionine cytidine IMP sn-glycerol EO219_RS10160 Tgt: 2-thiouridylate)- transferase branching branching cobyrinate a,c- cob(II)yrinate panB GDP phosphoribosyltransferase: thiamine -C(2))- methylthiotransferase cysteine synthase: ribazoletransferase: protein] EO219_RS10160 protein] subunit alpha: acyltransferase: pyrophosphohydrolase: ribosyltransferase- purine-nucleoside deaminase: dehydrogenase: 3-phosphate [+ 2 isozymes] EO219_RS12105 methyltransferase: family protein: protein protein nicotinate-nucleotide-- ribazoletransferase: cobT phosphate MtaB: mtaB 6 EO219_RS03730 cobS synthase [+ 2 isozymes] synthase: EO219_RS06870 a 1-acyl-2-EO219_RS06780 diamide synthase: a,c-diamide EO219_RS12110 phosphorylase: a 2-methylsulfanyl-N -L- phenyl-Coβ- a 2-methyl GlgB: glgB GlgB: glgB dimethylbenzimidazole isomerase QueA: queA cdd thymidine guaB an unsulfurated 34 EO219_RS09760 EO219_RS00300 (2R,5S)-2,5- EO219_RS03550 2-dehydropantoate cobS 5-hydroxybenzimidazolyl adenosylcobamide synthase: thiE met 5'-deoxyadenosine threonylcarbamoyladenine 37 acetate met II: fabF branched a queuosine acpS palmitoyl-sn a (1,6)-α-D-glucosyl- adenine ribotide deoD XMP GMP adenosylcobamide AMP diphosphate linoleoyl-CoA guanine a 5-methylaminomethyl- phosphoribosyltransferase: 34 [sulfur carrier] a 3-oxoglutaryl- AMP diphosphate a holo-[AsbD acyl- acetate diaminohexanoate a GlgE-glycogen biosynthesis from adenosylcobinamide-GDP an epoxyqueuosine in tRNA in tRNA acyl-carrier protein 2,3,4-saturated in tRNA 34 3',5'-ADP -glycerol 3- (1,4)-α-glucan cob(II)yrinate Coα-[α-(2- adenosylcobinamide- phosphate GDP purine-nucleoside 2'-deoxyuridine 5'-phosphate 2-thiouridine in tRNA cobT [acp] methyl ester fatty acyl-CoA carrier protein] phosphate a,c-diamide methyladenin-9-yl)]-Co GDP thiamine phosphate phosphorylase: benzimidazole 5-hydroxybenzimidazole NaMN 5-methoxybenzimidazolyl adenosylcobamide epoxyqueuosine purine-nucleoside 2'-deoxyinosine DHAP adenosylcobinamide- ribotide β-adenosylcobamide reductase QueH: phosphorylase: deoD uridine thymine GDP β-alanine adenosylcobinamide- biosynthesis from adenosylcobinamide-GDP phosphorylase: a 3-methyl- 1-arachidinoyl- a [lipoyl-carrier phosphate (R)-pantoate 5'-phosphate nicotinate-nucleotide-- EO219_RS11215 deoD α,ω-9Z- α a [formate C 18-hydroxyoleate a glutaryl-[acp] sn-glycerol a protein with an apo-[aryl- 6 a 1,4- -D-glucan GDP udp SAM a reduced flavodoxin a (3Z)-dodec-3-enoyl-[acp] a malonyl-[acp] a malonyl-[acp] branched 2,3,4- a stearoyl-[acp] glutathione coenzyme A roseoflavin sn-glycerol protein]-N -[(R) a protein dimethylbenzimidazole 5-methoxybenzimidazole purine-nucleoside purine-nucleoside acetyltransferase]-glycine methyl ester octadecenedioate 3-phosphate a disulfide bond carrier protein] ATP ribazoletransferase: a queuosine 34 in tRNA xanthosine long-chain fatty saturated fatty acid long-chain-fatty- 5'-phosphate 3-phosphate -dihydrolipoyl]- 1,4-alpha- adenosylcobinamide- phosphoribosyltransferase: phosphorylase: pyruvate beta-ketoacyl- beta-ketoacyl- long-chain fatty glycerol-3- glutaredoxin: holo-[acyl- 1-acyl-sn-glycerol- ATP-dependent pantoate--beta- cobS phosphorylase: uracil 2-deoxy-α- C1 Compound Utilization acid--CoA ligase: acid--CoA ligase: bifunctional L-lysine glucan GDP Coα-[α-(2- cobT thiamine diphosphate nicotinate-nucleotide-- deoD formate lyase- [acyl-carrier- [acyl-carrier- acid--CoA ligase: phosphate 1-O- EO219_RS08930 carrier- 3-phosphate dihydrolipoamide Clp protease alanine ligase: deoD D-ribose 1- and Assimilation EO219_RS10160 EO219_RS11235 riboflavin kinase/ branching ribazoletransferase: methyladenin-7-yl)]-Co dimethylbenzimidazole purine-nucleoside activating protein] protein] EO219_RS10160 acyltransferase: glutaredoxin: protein] acyltransferase: dehydrogenase: proteolytic subunit: EO219_RS00610 5-hydroxybenzimidazole Coα-[α-(adenin-9-yl)]- purine-nucleoside phosphate FAD synthetase: protein cobS β-adenosylcobamide phosphoribosyltransferase: phosphorylase: protein: pflA synthase II: fabF [+ 2 isozymes] synthase [+ 2 isozymes] [+ 2 isozymes] plsY EO219_RS00235 synthase: a 1-arachidonoyl-EO219_RS06780 EO219_RS08925 EO219_RS11340 adenosylcobinamide-GDP ribotide phosphate Coβ-adenosylcobamide phosphorylase: phosphopentomutase: formate assimilation into 5,10- a [formate C a 3-methyl- ω-carboxy- 1-stearoyl- a protein with a [lipoyl-carrier GlgB: glgB cobT deoD a flavodoxin a (5Z)-3-oxo- 18-hydroxyoleoyl- II: fabF acpS roseoflavin adenineEO219_RS07460 2-acyl-sn-glycerol α α 5'-phosphate 5-oxo-L-proline metabolism met 5'-deoxyadenosine acetyltransferase]- acyl-carrier protein branched acyl-carrier protein sn-glycerol reduced L- GSSG 6 a peptide Co -[ - (R)-pantothenate deoD EO219_RS02160 methylenetetrahydrofolate semiquinone tetradec-5-enoyl-[acp] AMP diphosphate a 3-oxopimeloyl- diphosphate AMP AMP diphosphate (9Z)-octadec- a holo-[aryl- protein]-N - a glycogen 5-methoxybenzimidazole purine-nucleoside glycin -2-yl radical CoA acyl-carrier protein 2,3,4-saturated 3-phosphate cysteine residues 3',5'-ADP dinucleotide 3-phosphate lipoyl-L-lysine (benzimidazolyl)]-Co adenosylcobinamide- 5-methylbenzimidazolyl adenosylcobamide adenosylcobinamide-GDP a [protein] with a [protein] with 2-deoxy-D-ribose [acp] methyl ester 9-enoyl-CoA carrier protein] β ribotide phosphate 2-deoxy-α-D- phosphorylase: formate fatty acyl-CoA -adenosylcobamide GDP biosynthesis from adenosylcobinamide-GDP 5-phosphate an N-terminal an N-terminal ribose 1-phosphate deoD formate--tetrahydrofolate 5'-phosphate thiamine diphosphate ribazoletransferase: cobS α α L-glutamine L-glutamate Co -[ -(adenin-7-yl)]- adenosylcobinamide- ligase: EO219_RS02870 biosynthesis III β 5-methylbenzimidazole NaMN phosphopentomutase: 4-methylphenyl DNA combined with a (3R)-3- a (3R)-3- (R)-4'- Co -adenosylcobamide deoxyribose- xanthine adenosylcobinamide- a 2,3,4-saturated a 2,3,4-saturated 2- octanoate sn-glycerol a peptide with a [EntF L-seryl- 1-(18-hydroxyoleoyl)- an L-aspartyl- a 1,4-α-D-glucan (Staphylococcus) GDP EO219_RS02160 formate--tetrahydrofolate O-acetyl-L-serine hydrogen selenide a (3Z)-docos-3-enoyl-[acp] a malonyl-[acp] ribotide exogenous DNA to form a myristoyl-[acp] coenzyme A hydroxyhexacosanoyl- hydroxyicosanoyl- phosphopantothenate Coα-[α-(5-hydroxybenzimidazolyl)]- phosphate sn-glycrol 3-phosphate [tRNA Asn ] nicotinate-nucleotide-- ribazoletransferase: cobS ligase: EO219_RS09915 GDP phosphate fatty acyl-[acp] lysophosphatidate a recombinational junction long-chain fatty 3-phosphate leader sequence carrier protein] 1,4-alpha- Coα-[α- HMP-PP Coβ-adenosylcobamide 5'-phosphate 2-deoxy-D-ribose aldolase: O-acetylhomoserine beta-ketoacyl- adenosylcobinamide- 1-acyl-sn-glycerol- Holliday junction glycerol-3- signal holo-[acyl- 1-acyl-sn-glycerol- Asp-tRNA(Asn) [acp] 3-hydroxyacyl- [acp] 3-hydroxyacyl- dimethylbenzimidazole a 10-formyltetrahydrofolate acid--CoA ligase: glucan 5-methoxy-6-methylbenzimidazolyl adenosylcobamide (benzimidazolyl)]-Co thiamine a [protein] with 5-phosphate deoC aminocarboxypropyltransferase/ [acyl-carrier- GDP 3-phosphate resolvase RuvX: ruvX phosphate 1-O- peptidase I: lepB carrier- 3-phosphate /Glu-tRNA(Gln) ACP ACP β phosphoribosyltransferase: Coα-[α-(5-methoxybenzimidazolyl)]- Fatty Acid and Lipid Biosynthesis γ-L-glutamyl EO219_RS10160 branching biosynthesis from adenosylcobinamide-GDP -adenosylcobamide phosphate an N-terminal 5- glutathione bifunctional 5,10- cysteine synthase: protein] ribazoletransferase: acyltransferase: crossover junction acyltransferase: signal protein] acyltransferase: amidotransferase: dehydratase dehydratase cobT Coβ-adenosylcobamide 5'-phosphate 5-phosphate urate [+ 2 isozymes] protein synthase: oxo-L-proline deoxyribose- D-glyceraldehyde methylenetetrahydrofolate EO219_RS03730 synthase II: fabF cobS EO219_RS06780a 2,3,4-saturated endodeoxyribonuclease plsY1-myristoyl- peptidase I: lepB synthase: 1-[18-hydroxyoeoyl]-2-EO219_RS06780 gatC gatA gatB FabZ: fabZ FabZ: fabZ 5-methoxy-6-methylbenzimidazole adenosylcobalamin biosynthesis from adenosylcobinamide-GDP I α α palmitate biosynthesis II acetaldehyde a (5Z)-3-oxotetracos- 4-methylphenyl-Co an L-asparaginyl- a trans-hexacos- a (2E)-icos- GlgB: glgB thiE Co -[ -(5-hydroxybenzimidazolyl) palmitoleate phosphatidylglycerol biotin-carboxyl carrier phosphate 3-phosphate dehydrogenase/5,10- acetate L-selenocysteine acyl-carrier protein 1,2-diacyl-sn resolution of recombinationalRuvC: ruvC acyl-carrier protein sn-glycerol a leader sequence a peptide a holoacpS-[EntF [18-hydroxy-lioleoyl]-sn thiamine β 5-methylbenzimidazole ribotide phosphate (bacteria and plant cytoplasm) purine ribonucleosides degradation 5-enoyl-[acp] GMP β-adenosylcobamide acyl-carrier protein diphosphate AMP octanoyl-CoA [tRNA Asn ] 2-enoyl-[acp] 2-enoyl-[acp] starch ]-Co -adenosylcobamide adenosylcobinamide-GDP biosynthesis I (from biosynthesis I (plastidic) protein assembly aldolase: deoC methenyltetrahydrofolate -glycerol 3- junction formation 3-phosphate 3',5'-ADP L-seryl-carrier -glycerol 3-phosphate nicotinate-nucleotide-- phosphate 5'-phosphate 5,6-dimethylbenzimidazole (5Z)-dodec-5-enoate) cyclohydrolase: phosphate of two intact strands protein] dimethylbenzimidazole Coα-[α-(5-methoxybenzimidazolyl) a [biotin carboxyl- an acetoacetyl-[acp] DHAP EO219_RS12140 phosphoribosyltransferase: adenosylcobinamide-GDP ]-Coβ-adenosylcobamide a (5Z)-dodec- carrier protein]-L-lysine 5-oxo-L-proline acetaldehyde D-glyceraldehyde 3-phosphate adenosine nicotinate-nucleotide-- NAD(P)H- acetyl-CoA S-methyl-5'- cobT ribazoletransferase: cobS 5-enoyl-[acp] undecaprenyl-diphospho-N an E. coli 1-cis-vaccenoyl- 1-myristoyl- 1-cis-vaccenoyl- a (3R)-3- a (3R,6Z)-3- a glucosylated dimethylbenzimidazole folate polyglutamylation beta- dependent glycerol- biotin--[acetyl-CoA- 5-oxoprolinase thioadenosine degradation I a 5,10-methenyltetrahydrofolate sn-glycerol a maltodextrin acetyl-CoA 1-cis-vaccenoyl-sn- 5-methoxy-6-methylbenzimidazole phosphoribosyltransferase: carboxylase] ligase: -acetylmuramoyl-L-alanyl-γ- UDP-N-acetyl-α-D-glucosamine osmoregulated an L-1- a cis-delta19-C38:1-[acp] a malonyl-[acp] a palmitoleoyl-[acp] sn-glycerol- a myristoyl-[acp] sn-glycerol a palmitoyl-[acp] sn-glycerol- hydroxytetracosanoyl- hydroxyoctadec- glycogenin thiamine Coα-[α-(5-methylbenzimidazolyl)]- ketoacyl- 3-phosphate subunit a purine ribonucleoside arsenate 3-phosphate glycogen/starch/ glycerol-3-phosphate 1,4-alpha- adenosylcobinamide-GDP ribotide phosphate cobT EO219_RS09280 S-methyl-5'- bifunctional 5,10- D-glutamyl-L-lysyl- D-alanine undecaprenyldiphospho- periplasmic phosphatidylethanolamine beta-ketoacyl- 1-acyl-sn-glycerol-3-phosphate 1-acyl-sn-glycerol-3-phosphate glycerol-3- acetyl-CoA carboxylase 1-acyl-sn-glycerol- 3-phosphate1-acyl-sn-glycerol- [acp] 3-hydroxyacyl- 6-enoyl-[acp]3-hydroxyacyl- a tetrahydrofolate β [acyl- dehydrogenase: PxpB: pxpB phosphoethanolamine purine-nucleoside thiamine Co -adenosylcobamide 5'-phosphate pyridoxal 5'-phosphate salvage I a (3R)-3- a [biotin carboxyl- thioadenosine methylenetetrahydrofolate muramoylpentapeptide beta-N- glucan (OPG) alpha-glucan carboxyltransferase: 3-phosphate 3-phosphate glucan carrier- EO219_RS09770 acetyl-CoA 5'-methylthioadenosine/ transferase: [acyl-carrier- phosphorylase: deoD 3-phosphate 3-phosphate phosphate 1-O- ACP ACP thiamine adenosylcobinamide-GDP α-ribazole 5'-phosphate diphosphokinase: hydroxybutanoyl-[acp] sn-glycerol carrier protein]-N dehydrogenase/5,10- acetylglucosaminyltransferase: phosphorylase: EO219_RS00740 acyltransferase: acyltransferase: branching adenosylcobinamide-GDP protein] glu adenosylhomocysteine an E. coli EO219_RS10665osmoregulated protein] acyltransferase: acyltransferase: acyltransferase: dehydratase dehydratase diphosphate EO219_RS05755 6 -biotinyl-L-lysine methenyltetrahydrofolate purine-nucleoside EO219_RS09995 EO219_RS00745 EO219_RS06780 protein ribazoletransferase: cobS bifunctional formate--tetrahydrofolate serine pyridoxamine 3-hydroxyacyl- synthase 3-phosphate xanthosine adenosine inosine guanosine nucleosidase: ditrans,octacis-undecaprenyldiphospho-murG a 1,2-diacyl- periplasmic glucan with synthase II: fabF EO219_RS067801-cis-vaccenoyl- EO219_RS067801,2-dimyristoyl- plsY1-palmitoyl- α-D- 1-cis-vaccenoyl- 1,2-dicis- EO219_RS06780 FabZ: fabZ a (2E,6Z)-FabZ: fabZ biosynthesis cyclohydrolase: a cis-delta21-3- phosphorylase: deoD [+ 3 isozymes] a trans-tetracos- GlgB: glgB thiamine folylpolyglutamate ligase: EO219_RS02870 hydroxymethyltransferase: pyridoxine ACP a (7Z)-3-II: fabF glycerol-3- EO219_RS00840 UDP N-acetyl-(N-acetylglucosaminyl)muramoyl- sn-glycerol phosphotidylethanolamine acyl-carrier protein 2-palmitoleoyl- acyl-carrier protein sn-glycerol acyl-carrier protein sn-glycerol glucopyranose a maltodextrin 2-palmitoleoyl-sn- vaccenoyl- octadecadienoyl- II (Bacillus) adenosylcobinamide-GDP Coα-[α-(5-methylbenzimidazolyl) EO219_RS12140 oxo-C40:1-[acp] ribose-1-arsenate a purine base acyl-carrier protein 2-enoyl-[acp] a glycogen α α diphosphate synthase/dihydrofolate formate--tetrahydrofolate EO219_RS07260 pyridoxamine oxotetradec- MTR L-alanyl-γ-D-glutamyl-L-lysyl-D-alanine substituent 1-phosphate malonyl-CoA glycerol-3-phosphate phosphatidate Co -[ -(5-methoxy-6-methylbenzimidazolyl) HMP-PP ribazoletransferase: cobS ]-Coβ-adenosylcobamide dehydratase phosphate 1-O- sn-glycerol- 3-phosphate 3-phosphate [acp] β synthase: EO219_RS00835 ligase: EO219_RS09915 kinase: 7-enoyl-[acp] a [biotin carboxyl- purine-nucleoside purine-nucleoside purine-nucleoside purine-nucleoside ]-Co -adenosylcobamide 5'-phosphate thiamine FabZ: fabZ acyltransferase: S-methyl-5- a 5,10-methylenetetrahydrofolate 3-phosphate EO219_RS00440 6 phosphorylase: phosphorylase: phosphorylase: phosphorylase: phosphate a 5,10-methylenetetrahydrofolate plsY carrier-protein dimer]- N -L- 6 37 thioribose kinase: adenosylcobalamin 5'-phosphate a (2E)-but-2-enoyl-[acp] a 1-acyl-sn N -biotinyl-L-lysine threonylcarbamoyladenosine deoD deoD deoD deoD 6 synthase: a tetrahydrofolate pyridoxine pyridoxamine 2503 an N -L- a 10-formyltetrahydrofolate EO219_RS08405 adenine a long-chain 1-palmitoyl- a linear malto- a long-linear adenine 1518 / a cytidine 1402 a (3R)-3- a (3R,11Z)-3- α thiamine salvage III bifunctional 5'-phosphate 5'-phosphate -glycerol 3- acetyl-CoA acetyl-CoA -modified tRNA biosynthesis purine-nucleoside purine-nucleoside purine-nucleoside purine-nucleoside 37 7-hydroxylaurate α -amylose thiE a (3R,7Z)-3- in 23S rRNA threonylcarbamoyladenine a cis-delta17-C36:1-[acp] a malonyl-[acp] 2,3,4-saturated a palmitoyl-[acp] sn-glycerol oligosaccharide -D-glucan 1519 L-homoserine hydroxydocosanoyl- hydroxyoctadec- Coα-[α-(5-methoxy-6-methyl- thiamine bifunctional folylpolyglutamate phosphate carboxylase carboxylase phosphorylase: phosphorylase: phosphorylase: phosphorylase: adenine in 16S rRNA in 16S rRNA pyridoxal hydroxytetradec- 5-MTR-1-P 23S rRNA in tRNA long-chain fatty fatty acid 3-phosphate glycogen/starch/ glycogen/starch/ ribosomal RNA 16S rRNA [acp] 11-enoyl-[acp] 1,4-alpha- benzimidazolyl)]-Coβ-adenosylcobamide phosphate synthase/dihydrofolate 1-acyl-sn-glycerol- carboxyltransferase: biotin thr beta-ketoacyl- long-chain fatty 1-acyl-sn-glycerol- 3-hydroxyacyl- 3-hydroxyacyl- thiamine folylpolyglutamate pyridoxamine 5'- pyridoxamine 5'- 7-enoyl-[acp] deoD deoD deoD deoD (adenine(2503)-C(2) tRNA acid--CoA ligase: alpha-glucan alpha-glucan small subunit (cytidine(1402)-2'-O) homoserine O- glucan synthase: EO219_RS00835 3-phosphate EO219_RS00740 carboxylase threonylcarbamoyl- [acyl-carrier- acid--CoA ligase: 3-phosphate ACP ACP thiamine synthase/dihydrofolate phosphate oxidase: phosphate oxidase: pyrimidine )-methyltransferase threonylcarbamoyladenosine EO219_RS10160 phosphorylase: phosphorylase: methyltransferase -methyltransferase: succinyltransferase: branching adenosylcobalamin synthase: EO219_RS00835 acyltransferase: EO219_RS00745 subunit: accC AMP synthase: α-D-ribose- dehydratase: EO219_RS00270 protein] EO219_RS10160 acyltransferase: metA dehydratase dehydratase diphosphokinase: EO219_RS07740 EO219_RS07740 a butanoyl-[acp] RlmN: rlmN 6 EO219_RS09995 EO219_RS09995 A: rsmA rsmI protein a 5,10-methylenetetrahydrofolate EO219_RS06780 EO219_RS03830 ribonucleosides a cyclic N -L- synthase II: fabF [+ 2 isozymes] [+ 2 isozymes] EO219_RS06780 α-D- α-D- N 6 -dimethyladenine 1518 a 2'-O- FabZ: fabZ a (2E,11Z)-FabZ: fabZ EO219_RS05755 a [carboxyl-carrier (L-threonylcarbamoyl) 1-phosphate a 2-methyladenine 2503 a long-chain a linear malto- a long-linear O-succinyl-L- GlgB: glgB a (2E,7Z)- a 1,2-diacyl- 6 degradation threonylcarbamoyladenosine a cis-delta19-3- dipalmitoyl 6 1519 1402 a (2E)-docos- thiamine thiamine a 10-formyltetrahydrofolate protein dimer]-N - adenylate S-methyl-5'-thioadenosine 5'-deoxyadenosine met acyl-carrier protein 7-hydroxylauroyl- acyl-carrier protein glucopyranose glucopyranose α /N -dimethyladenine methylcytidine octadeca-2,11- beta-ketoacyl- tetradeca-2,7- sn-glycerol phosphopentomutase: cytidine in 23S rRNA oxo-C38:1-[acp] AMP diphosphate AMP diphosphate 2,3,4-saturated phosphatidate oligosaccharide -D-glucan homoserine 2-enoyl-[acp] amylopectin diphosphate diphosphate PLP carboxybiotinyl-L-lysine degradation IV 37 in tRNA CoA 1-phosphate 1-phosphate in 16S rRNA in 16S rRNA dienoyl-[acp] [acyl-carrier- dienoyl-[acp] 3-phosphate EO219_RS02160 cytidine fatty acyl CoA protein] phosphatidate S-methyl-5'- D-ribose 5- deaminase: cdd synthase cytidylyltransferase: an N 6 -L- thioadenosine phosphate uridine 5'-methylthioadenosine/ 1402 37 a 1-alkyl-sn II: fabF 37 decaprenyl-diphospho-N- UDP-N-acetyl- a single 1-palmitoyl- α a 3,5,7,9,11,13,15- a cytidine adenine EO219_RS00990 threonylcarbamoyladenine adenosylhomocysteine uridine α-linolenate pristanate a cis- a 1,4- -D-glucan sn-glycerol phosphatidylserine and acetylmuramoyl-pentapeptide α-D-glucosamine stranded DNA a cis-delta15-C34:1-[acp] a malonyl-[acp] sn-glycerol hepta-oxo- in 16S rRNA in tRNA val -glycerol 3- a protein Aromatic Compound a (7Z)-tetradec- in tRNA phosphorylase: vaccenoyl-[acp] ATP H O 1 3-phosphate Cell Structure Biosynthesis phosphatidate phosphatidylethanolamine nucleosidase: undecaprenyldiphospho- exodeoxyribonuclease long-chain-fatty- long-chain fatty 3-phosphate glycogen/starch/ 2 hexadecanoyl-[PKS-acp] 16S rRNA tRNA1(Val) phosphate glycerol-3- Biosynthesis a 3-oxohexanoyl-[acp] 7-enoyl-[acp] udp beta-ketoacyl- 1-acyl-sn-glycerol- ATPase: 1-acyl-sn-glycerol- cytidylyltransferase: biosynthesis I EO219_RS00840 muramoylpentapeptide beta-N- VII large subunit: xseA acid--CoA ligase: acid--CoA ligase: alpha-glucan aldo/keto (cytosine(1402)-N(4) (adenine(37)-N6)- phosphate 1-O- [acyl-carrier- 3-phosphate EO219_RS02350 3-phosphate endopeptidase peptidoglycan biosynthesis I beta- EO219_RS06785 MTR uracil acetylglucosaminyltransferase: exodeoxyribonuclease EO219_RS11235 EO219_RS10160 phosphorylase: reductase: )-methyltransferase methyltransferase: acyltransferase: lipid IV biosynthesis (P. putida) chorismate biosynthesis I a CDP-diacylglycerol protein] acyltransferase: acyltransferase: La: lon A ketoacyl- a CDP- murG EO219_RS09995 [+ 2 isozymes] EO219_RS07705 (meso-diaminopimelate containing) lipid IV biosynthesis (E. coli) VII small subunit: xseB [+ 2 isozymes] [+ 2 isozymes] α 4 RsmH: rsmH 6 EO219_RS06110 EO219_RS06780 plsY A CDP-diacylglycerol--serine decaprenyl-pyrophosphoryl- synthase II: fabF EO219_RS067801-palmitoyl-2- -D- 9-hydroxy-3,5,7,11,13,15- an N - an N - a 2-acyl-1-alkyl- 1-arachidinoyl- Aminoacyl-tRNA Charging [acyl- diacylglycerol a single-stranded a ribonucleoside a cis-delta17-3- H + phosphate ADP UDP-N-acetyl- D-erythrose O-phosphatidyltransferase: Amine and Polyamine Degradation UDP (N-acetylglucosamine)-N- acyl-carrier protein acyl-carrier protein cis-vaccenoyl glucopyranose a 1,4-α-D-glucan hexaoxohexadecanoyl- methylcytidine 1402 methyladenine 37 sn-glycerol sn-glycerol a peptide a (3R)-3- a (3R)-3- UDP-N-acetyl- carrier- Glycolysis oligodeoxyribonucleotide 5'-monophosphate oxo-C36:1-[acp] AMP diphosphate α-linolenoyl-CoA AMP diphosphate pristanoyl-CoA α-D-glucosamine UDP-N-acetyl- 4-phosphate a (3R)-3- CDP-diacylglycerol-- pssA acetylmuramyl-(pentapeptide) phosphatidate 1-phosphate [PKS-acp] in 16S rRNA in tRNA val 3-phosphate 3-phosphate tRNA charging α-D-glucosamine 3-deoxy-7- protein] 1 gln hydroxytetradecanoyl- hydroxydecanoyl-[acp] hydroxyhexanoyl-[acp] glycerol-3-phosphate 3- a 3-sn-phosphatidyl- Fatty Acid and Lipid Degradation glutaminyl-tRNA UDP-N-acetylglucosamine α-D-glucosamine phosphoheptulonate superpathway of N-acetylglucosamine, [acp] UDP-3-O-[(3R)-3- synthase phosphatidyltransferase: L-serine glycolysis I (from glucose 6-phosphate) biosynthesis via transamidation 1-carboxyvinyltransferase: UDP-3-O-[(3R)-3- synthase: aroF 3-hydroxyacyl- II: fabF N-acetylmannosamine and N- arginine-- murA hydroxydecanoyl]-N- pgsA phosphatidylserine oleate β-oxidation arg hydroxymyristoyl]-N- 3-deoxy-7- ACP a (9Z)-3- fatty acid β-oxidation I acetylneuraminate degradation 2,5-diamino-6-(5- 2-amino-6-[1-hydroxyethyl]- 1-palmitoyl- a plant soluble a 2'- a guanine 527 a cytidine 34 a [protein]- tRNA ligase: α acetyl-α-D-glucosamine 1-(3-sn- decarboxylase: D-glucopyranose pentadecanoate phytenate an L-glutamyl- UDP-N-acetyl- - α dehydratase phospho-D-ribitylamino) a cis-delta13-C32:1-[acp] a malonyl-[acp] sn-glycerol a myristoyl-[acp] heteroglycan deoxyribonucleoside [DNA] Gln D-serine EO219_RS05600 glu acetyl- -D-glucosamine phosphoheptulonate oxohexadec- phosphatidyl) EO219_RS05025 6-phosphate N-acetylneuraminate 7-methyl-7,8-dihydropterin GTP H O in 16S rRNA in tRNA [tRNA ] L-histidine an L-arginyl- glycogen/starch/ 2 histidine kinase: D-glucosamine- UDP-3-O-[3- synthase: aroF FabZ: fabZ 9-enoyl-[acp] oleate N-acetylneuraminate pyrimidin-4(3H)-one 2-amino-4-hydroxy-6- long-chain fatty long-chain-fatty- 3-phosphate 5'-triphosphate DNA polymerase 16S rRNA tRNA (cytidine(34) Asp-tRNA(Asn) Arg 3-deoxy- -sn-glycerol an L-1- a (3Z)-alk-3-enoyl-CoA bifunctional beta-ketoacyl- 1-acyl-sn-glycerol- GTPase Era: D-serine [tRNA ] enolpyruvate hydroxymyristoyl] N- glucose-6- lyase: acid--CoA ligase: acid--CoA ligase: alpha-glucan (guanine(527)-N(7) -2'-O)- EO219_RS05150 Arg 3-phosphate diaminohydroxyphosphoribosylaminopyrimidine hydroxymethyldihydropteridine [acyl-carrier- 3-phosphate III subunit alpha: /Glu-tRNA(Gln) ammonia- a tRNA UDP-N- UDP-3-O-(3- D-arabino- a (2E)-hex-2-enoyl-[acp] phosphatidylethanolamine long-chain fatty EO219_RS10160 EO219_RS11235 phosphorylase: EO219_RS00865 )-methyltransferase methyltransferase: histidine kinase: acetylglucosamine phosphate N-acetyl-D-EO219_RS10925 deaminase/5-amino-6-(5-phosphoribosylamino) diphosphokinase: folK protein] acyltransferase: EO219_RS11540 amidotransferase: lyase: acetylmuramate hydroxydecanoyl) heptulosonate phosphatidylglycerophosphatase acid--CoA ligase: [1-(2-amino-7-methyl-4-oxo- [+ 2 isozymes] [+ 2 isozymes] EO219_RS09995 [+ 5 isozymes] RsmG: rsmG EO219_RS05485 EO219_RS09820 deacetylase: lpxC isomerase: uracil reductase RibD: ribD synthase II: fabF EO219_RS06780 α-D- [+ 5 isozymes] an N 7 - a 2'-O- gatC gatA gatB a [protein]- dsdA α 7-phosphate a (3R,9Z)-3- A: EO219_RS05290 EO219_RS10160 mannosamine 1-palmitoyl- + an L-glutamyl- dehydrogenase: UDP-3-O-(3- - -D-glucosamine EO219_RS01795 5-amino-6-(5-phospho- 7,8-dihydro-3H-pteridin- a cis-delta15-3- a plant soluble phosphate GDP H 527 34 an L-glutaminyl- 3-dehydroquinate hydroxyhexadec- acyl-carrier protein pentadecanoyl- acyl-carrier protein 2-myristoyl glucopyranose [DNA] methylguanine methylcytidine Gln N-phospho- pyruvate [tRNA Gln ] murB hydroxymyristoyl) UDP-3-O-(3- an L-1- [+ 2 isozymes] D-ribitylamino)uracil 6-yl)]ethyl diphosphate oxo-C34:1-[acp] AMP diphosphate diphosphate AMP phytenoyl-CoA heteroglycan [tRNA ] long-chain-fatty- a trans-2-enoyl-CoA CoA 1-phosphate in 16S rRNA in tRNA L-histidine gln -α-D-glucosamine hydroxymyristoyl) synthase: aroB 9-enoyl-[acp] phosphatidyl- phosphatidate cys cysteine-- Asp-tRNA(Asn) UDP-N-acetyl- F6P oleoyl-CoA acid--CoA ligase: ala UDP-3-O-(3- glucosamine N- 3-dehydroquinate sn-glycerol a 2,3,4-saturated N-acetyl-D- tRNA ligase: α a hexanoyl-[acp] coenzyme A EO219_RS11235 acyl-CoA /Glu-tRNA(Gln) glutaminase -D-muramate hydroxymyristoyl) acyltransferase: synthase: aroB fatty acid mannosamine EO219_RS02335 an L-cysteinyl- amidotransferase: glu acyl-CoA [+ 2 isozymes] dehydrogenase: A: glsA glucosamine N- lpxD a (2E,9Z)- fructose- a (3R)-3- 6-phosphate core 1-cis-vaccenoyl- a guanine 966 a uracil 1498 1-palmitoyl- a double [tRNA Cys ] gatC gatA gatB UDP-N- 3-dehydroquinate beta-ketoacyl- dehydrogenase: EO219_RS03690 a cis,cis-delta13,31- 5'-deoxy-5'-fluoroadenosine a cis- maltohexaose a ribonucleoside sn-glycerol Cys bisphosphatase 6-phosphofructokinase: hydroxyacyl-CoA N-acetylmannosamine- an L-1- oligosaccharide- a cis-delta11-C30:1-[acp] a malonyl-[acp] a malonyl-[acp] sn-glycerol- 3'-dephospho- formate sn-glycerol a tRNA a 5-phosphooxy- [+ 4 isozymes] acetylmuramate- glutamate acyltransferase: UDP-3-O-(3- [acyl-carrier- hexadeca-2,9- EO219_RS00140 IMP C50:2-[acp] vaccenoyl-[acp] ATP triphosphate in 16S rRNA in 16S rRNA 3-phosphate stranded DNA class III: pfkA [+ 6 isozymes] phosphatidylethanolamine lipid A (E. coli purine-nucleoside 3-phosphate glycogen/starch/ CoA 16S rRNA 16S rRNA 3-phosphate DNA + + -L-alanine racemase: lpxD type II 3- protein] dienoyl-[acp] a 2,3,4-saturated a 2,3,4-saturated (3S 6-phosphate beta-ketoacyl- beta-ketoacyl- 1-acyl-sn-glycerol- anaerobic 1-acyl-sn-glycerol- glycerol-3- Na RS06985 Na L-glutamyl- ammonium hydroxymyristoyl) stearate biosynthesis EO219_RS09325 [+ 6 isozymes] phosphoethanolamineK-12 core type) phosphorylase: deoD alpha-glucan dephospho- (guanine(966)-N(2) (uracil(1498)-N(3))- gyrase Gln fatty acyl CoA )-3-hydroxyacyl-CoA 2-epimerase: bifunctional [acyl-carrier- [acyl-carrier- 3-phosphate ribonucleoside- 3-phosphate phosphate 1-O- [tRNA ] ligase: murC murI UDP-3-O-(3- glucosamine N- dehydroquinate synthase (2E,9Z)- phosphorylase: CoA kinase: UDP-N-acetyl- II (bacteria and plants) EO219_RS10930 phosphoribosylaminoimidazolecarboxamide transferase: protein] protein] purine-nucleoside acyltransferase: triphosphate )-methyltransferase methyltransferase: acyltransferase: acyltransferase: subunit hydroxymyristoyl) acyltransferase: dehydratase: aroQ II: fabF β-D-fructose 1,6- octadecenoyl-CoA N-acetyl-D- lipid A-core- EO219_RS09995 EO219_RS05300 α D-glt formyltransferase/IMP cyclohydrolase: purH EO219_RS10665 synthase II: fabF synthase II: fabF phosphorylase: deoD EO219_RS06780 α reductase: nrdD 2 RsmD: rsmD 3 EO219_RS00415 EO219_RS06780 plsY A: gyrA Asp-tRNA(Asn) -D-muramoyl- glucosamine N- EO219_RS04510 type II 3- bisphosphate a 1,2-diacyl- 1,2-dicis- -D- + an N - an N - a 1-palmitoyl-2- 1-oleoyl-sn a negatively glucosamine phosphoethanolamine a cis-delta13-3- a cis,cis-delta15,33- ADP coenzyme A H a 2'-deoxyribonucleoside + + gln /Glu-tRNA(Gln) L-alanine acyltransferase: UDP-2-N-[(3R)-3- a 3-oxooctanoyl-[acp] a palmitoyl-[acp] DHAP FAICAR sn-glycerol acyl-carrier protein acyl-carrier protein 5-fluoro-5-deoxy-D- acyl-carrier protein vaccenoyl- glucopyranose maltopentaose methylguanine 966 methyluracil 1498 acyl-sn-glycerol -glycerol 3- Na RS09250 Na dehydroquinate a palmitoleoyl-[acp] 6-phosphate (hep I) oxo-C32:1-[acp] 3-oxo-C52:2-[acp] adenine 5'-triphosphate supercoiled DNA amidotransferase: EO219_RS04510 hydroxydodecanoyl]-3-O- class II ribose 1-phosphate phosphatidate 1-phosphate in 16S rRNA in 16S rRNA 3-phosphate phosphate an L-glutaminyl- dehydratase: aroQ a 2,3,4-saturated a 2,3,4-saturated N-acetylglucosamine- gatC gatA gatB UDP-N- UDP-2-N,3-O-bis[(3R)- [(3R)-3-hydroxydecanoyl]- fructose-1,6- Gln (S)-3-hydroxy-(9Z) 6-phosphate [tRNA ] acetylmuramoyl- 3-hydroxytetradecanoyl]- α-D-glucosamine 3-dehydroshikimate a 3-oxooctadecanoyl- triose-phosphate bisphosphate fatty acyl CoA 3-oxoacyl-CoA a tRNA Gln -octadecenoyl-CoA deacetylase: nagA L-alanine-- α-D-glucosamine [acp] isomerase: aldolase: fba an L-glutaminyl- core a pseudouridine 1915 a DNA with α-D- D-arabinofuranose 1-myristoyl- D-ribose 5- D-glutamate a (3R)-3- EO219_RS03930 D-glucosamine phosphatidylglycerolphosphate decanoate a RNA-DNA hybrid (2S, 3S)-3- sn-glycerol [tRNA Gln ] palmitoleate an L-1- oligosaccharide- a (3Z)-dec-3-enoyl-[acp] a malonyl-[acp] an oleoyl-[acp] a malonyl-[acp] glucopyranose UTP sn-glycerol phosphate ligase: murD 6-phosphate (1-oleoyl, 2-palmitoyl) in 23S rRNA hypoxanthine 5-phosphate methylaspartate 3-phosphate hydroxyoctanoyl-[acp] phosphatidylethanolamine lipid A (E. coli long-chain fatty 23S rRNA DNA-deoxyinosine 1-phosphate ribonuclease HII: 3-deoxy-8- 3-phosphate glycerol-3- ribose 5- beta-ketoacyl- beta-ketoacyl- UTP--glucose- 1-acyl-sn-glycerol- lipid X (P. putida) D-glyceraldehyde 3-oxo-(9Z)- phosphatidylglycerophosphatase phosphoethanolamineK-12 core type) acid--CoA ligase: (pseudouridine(1915)- glycosylase: EO219_RS03910 phosphooctulonate methylaspartate phosphate 1-O- phosphate UDP-N-acetyl- shikimate 3-hydroxyacyl- a (3R)-3- acetyl-CoA [acyl-carrier- [acyl-carrier- 1-phosphate 3-phosphate meso- lipid X 3-phosphate octadecenoyl-CoA A: EO219_RS05290 transferase: EO219_RS10160 N(3))-methyltransferase EO219_RS08250 synthase: mutase subunit S: isomerase glu α-D-muramoyl-L- ACP protein] protein] ribonuclease HI: acyltransferase: acyltransferase: diaminopimelate lipid-A- hydroxyoctadecanoyl- α-D-glucosamine [+ 2 isozymes] RlmH: EO219_RS05840 uridylyltransferase EO219_RS01665 EO219_RS11380 B: rpiB shikimate kinase: dehydratase 1-oleoyl-2-palmitoyl- lipid A-core- EO219_RS10665a 1,2-diacyl- synthase II: fabF synthase II: fabF an N 3 - an apurinic site EO219_RS10540 1,2-dimyristoyl-EO219_RS06780 1-palmitoyl-plsY an L-glutamyl- alanyl-D-glutamate lipid-A- disaccharide [acp] hypoxanthine GalU: galU a nucleoside 5'- D-ribulose FabZ: fabZ long-chain fatty 6-phosphate a (5Z)-3-oxododec- an (11Z)-3-oxo- 1915 within DNA α Glu disaccharide synthase: lpxB EO219_RS11135 3-hydroxyacyl- phosphatidylglycerol pyrophosphoethanolamine sn-glycerol acyl-carrier protein acyl-carrier protein methylpseudouridine UDP- -D-glucose DNA KDO-8P glu sn-glycerol sn-glycerol 5-phosphate [tRNA ] acid activation glucosamine- 5-enoyl-[acp] icos-11-enoyl-[acp] diphosphate AMP decanoyl-CoA monophosphate glu UDP-N- synthase: lpxB ACP in 23S rRNA 3-phosphate 3-phosphate a tRNA lipid A disaccharide (P. putida) shikimate 3- a (2E)-oct-2-enoyl-[acp] (7Z)-hexadecenoyl-CoA Carbohydrate Degradation 6-phosphate acetylmuramoyl- lipid A disaccharide a long-chain dehydratase phosphate deaminase: L-alanyl-D- (E. coli) fatty acid FabZ: fabZ acyl-CoA glutamate--2, 6- tetraacyldisaccharide 3-phosphoshikimate 1- long-chain-fatty- 13-DPG D-galactose degradation I (Leloir pathway) EO219_RS08105 tetraacyldisaccharide a (2E)-octadec- dehydrogenase: glycogen degradation II 1-stearoyl- (5Z,8Z,11Z,14Z,17Z) a [protein]- a [protein]-L- phosphoenol 4'-kinase: lpxK carboxyvinyltransferase: acid--CoA ligase: a sulfurated a cis- sn-glycerol coenzyme A a glycogen succinyl-CoA acetoacetate FAD sn-glycerol roseoflavin diaminopimelate 2-enoyl-[acp] EO219_RS00140 F6P SAM dethiobiotin a cis,cis-delta3,21-C40:2-[acp] a malonyl-[acp] a cis-delta9-C28:1-[acp] a malonyl-[acp] an oleoyl-[acp] sn-glycerol -icosapentaenoate L-threonine asp proline (ω = 180) pyruvate isoleucine-- 4'-kinase: lpxK aroA EO219_RS11235 [sulfur carrier] vaccenoyl-[acp] 3-phosphate 3-phosphate ile ligase: lipid IV (P. putida) [+ 6 isozymes] β-D-galactopyranose biotin beta-ketoacyl-[acyl- 3-phosphate long-chain-fatty- glycogen/starch/ 3-oxoacid CoA- FAD:protein FMN peptidyl-prolyl cis- glycerol-3- bifunctional pyruvate tRNA ligase: D-ala A 5-enolpyruvoyl- [+ 2 isozymes] phosphoglycerate a glycogen beta-ketoacyl- 1-acyl-sn-glycerol- glycerol-3- pyridoxal phosphate- EO219_RS01670 lipid IV (E. coli) an octanoyl-[acp] a long-chain acid--CoA ligase: alpha-glucan transferase: transferase: trans isomerase: phosphate 1-O- riboflavin kinase/ EO219_RS09825 A shikimate 3- kinase: pgk (2E,7Z)- galactose synthase carrier-protein] [acyl-carrier- 3-phosphate phosphate 1-O- dependent kinase an L-isoleucyl- acyl-CoA glycogen/starch/ BioB: bioB synthase II: fabF EO219_RS11235 phosphorylase: EO219_RS05445 EO219_RS02960 EO219_RS01075 acyltransferase: FAD synthetase: PykF: pykF Ile D-alanine--D- phosphate hexadecenoyl-CoA mutarotase: protein] acyltransferase: acyltransferase: aminotransferase: [tRNA ] UDP-N-acetyl- beta-ketoacyl- an unsulfurated a cis,cis-delta5,23- [+ 2 isozymes] EO219_RS09995 [+ 2 isozymes] [+ 4 isozymes] plsY EO219_RS07460 Ile alanine ligase: chorismate EO219_RS07885 alpha-glucan met 5'-deoxyadenosine biotin acyl-carrier protein synthase II: fabF EO219_RS067801-stearoyl-2- plsY1-cis-vaccenoyl- α a [protein]-FMN- EO219_RS05220 1-C16:0-α,ω- a tRNA α-D-muramoyl- [acyl-carrier- a stearoyl-[acp] fatty acid elongation -- saturated 3-phospho- [sulfur carrier] 3-oxo-C42:2-[acp] a cis-delta11-3- (5Z,8Z,11Z,14Z,17Z) -D-glucopyranose AMP a [protein]-L- roseoflavin pyruvate EO219_RS02280 synthase: phosphorylase: acyl-carrier protein acyl-carrier protein oleoyl-sn-glycerol acyl-carrier protein sn-glycerol- maltotetraose acetoacetyl-CoA succinate L-threonine oxaloacetate ω dicarboxyl-2- L-alanyl-γ-D- protein] D-glycerate α oxo-C30:1-[acp] -icosapentaenoyl-CoA 1-phosphate proline ( = 0) 5'-phosphate EO219_RS09935 -D-galactopyranose EO219_RS09995 3-phosphate 3-phosphate lysophosphatidate glutamyl-meso-2,6- D-alanyl-D-alanine synthase (S)-3-hydroxy-(7Z) an acetoacetyl-[acp] 2,3- α diaminopimelate chorismate II: fabF 2,3-bisphosphoglycerate- -hexadecenoyl-CoA galactokinase: an -limit dextrin leucine-- diphosphoglycerate- an O 6 - 1-stearoyl- 1-palmitoyl- leu independent EO219_RS07760 4-alpha- a cis,cis-delta19- a [protein]- an acyl-[acyl- (S)-5-amino-3- maltotetraose succinyl-CoA a 3-oxo acid a supercoiled duplex DNA an insertion sequence palmitoleoyl-CoA UDP-N- a 3-oxodecanoyl-[acp] dependent a cis,cis-delta9,27-C46:2-[acp] a malonyl-[acp] a cis,cis-delta9,21-C40:2-[acp] a malonyl-[acp] a malonyl-[acp] methylguanine sn-glycerol acetyl-CoA sn-glycerol phosphoenol tRNA ligase: stearate phosphoglycerate glucanotransferase: 37-C56:2-[acp] L-cysteine carrier protein] oxohexanoate element IS30 dADP acetylmuramoyl- phosphoglycerate α-D-galactose in DNA 3-phosphate 3-keto-5- glycogen/starch/ 3-oxoacid CoA- replicative DNA acyl-CoA 3-phosphate pyruvate EO219_RS02235 an L-leucyl- mutase: UDP-α-D-glucose malQ beta-ketoacyl-[acyl- beta-ketoacyl-[acyl- beta-ketoacyl- methylated-DNA-- 1-acyl-sn-glycerol- transposase: 1-acyl-sn-glycerol- pyruvate tripeptide--D- long-chain fatty mutase: 3-oxo-(7Z)- 1-phosphate aminohexanoate alpha-glucan transferase: helicase: dnaB dehydrogenase: [tRNA Leu ] EO219_RS03935 a debranched carrier-protein] carrier-protein] [acyl-carrier- [protein]-cysteine S- 3-phosphate EO219_RS11535 3-phosphate kinase Leu alanyl-D- alanine acid--CoA ligase: a 3-oxoacyl-[acp] EO219_RS02375 hexadecenoyl-CoA cleavage protein: phosphorylase: EO219_RS05445 helicase: EO219_RS00140 a tRNA α-limit dextrin synthase II: fabF synthase II: fabF protein] methyltransferase: acyltransferase: [+ 4 isozymes] acyltransferase: PykF: pykF ligase: murF EO219_RS10160 a cis,cis-delta11,29- a cis,cis-delta11,23- EO219_RS06845 EO219_RS09995 [+ 2 isozymes] EO219_RS10210 an insertion [+ 6 isozymes] acyl-carrier protein acyl-carrier protein synthase II: fabF EO219_RS09130 EO219_RS06780a 1-stearoyl 2- α 1-palmitoyl-EO219_RS06780 a (3R)-3- 2-phospho- 3-oxo-C48:2-[acp] 3-oxo-C42:2-[acp] a cis,cis-delta21,39- a [protein]-S- (S)-3- -D-glucopyranose a 2,3,4-saturated sequence IS30 with (2E,9Z)- dATP pyruvate [+ 2 isozymes] glycogen/starch/ acyl-carrier protein a guanine in DNA acyl-carrier protein acyl-sn-glycerol acetoacetate maltotriose succinate a single stranded DNA 2-myristoyl UDP-N-acetyl- hydroxydecanoyl-[acp] D-glycerate 3-oxo-C58:2-[acp] methyl-L-cysteine aminobutanoyl-CoA 1-phosphate 3-oxoacyl-CoA integrated transposon hexadecenoyl-CoA α stearoyl-CoA alpha-glucan 3-phosphate phosphatidate -D-muramoyl- 3-hydroxyacyl- (5Z)-tetradecenoyl-CoA γ beta-ketoacyl- phosphopyruvate phosphorylase: val L-alanyl- -D- ACP D-glucopyranose valine--tRNA ligase: [acyl-carrier- hydratase: EO219_RS09995 4 α 3-(4- 1-palmitoyl- glutamyl-meso-2,6- di-trans,octa-cis dehydratase acyl-CoA an O - -Kdo-(2->4)- a DNA methyl a [protein]- a dimer of non- a cytosine 967 (7Z)- EO219_RS11320 protein] EO219_RS10945 a cis,cis-delta17,35- a [protein]- α hydroxyphenyl) L-cysteate sn-glycerol phosphoenol an L-valyl- diaminopimeloyl- -undecaprenyl FabZ: fabZ dehydrogenase: α a cis,cis-delta7,25-C44:2-[acp] a malonyl-[acp] a cis,cis-delta7,19-C38:2-[acp] a malonyl-[acp] a malonyl-[acp] methylthymine a dodecanoyl-[acp] -Kdo-(2->6)- phosphotriester L-cysteine adjacent 2'- ν in 16S rRNA tetradecenoyl-CoA dGDP Val a 2,3,4-saturatedsynthase II: fabF a (3R)-3-hydroxyacyl- -D- C54:2-[acp] L-cysteine h [tRNA ] D-alanyl-D-alanine phosphate EO219_RS03690 in DNA lipid IV (E. coli) methylated-DNA-- deoxycytidines pyruvate 16S rRNA pyridoxal phosphate- acyl-CoA 3-phosphate pyruvate beta-ketoacyl-[acyl- beta-ketoacyl-[acyl- beta-ketoacyl- methylated-DNA-- lauroyl A 1-acyl-sn-glycerol- Val fatty acyl-[acp] 3-hydroxyacyl-[acyl-carrier protein] phosphoenol glucopyranose 4-hydroxyphenylpyruvate pyruvate a tRNA a (2E)-dec-2-enoyl-[acp] [+ 6 isozymes] carrier-protein] carrier-protein] [acyl-carrier- acyltransferase: [protein]-cysteine S- in DNA deoxyribodipyrimidine (cytosine(967)-C(5) dependent dehydrogenase: 3-phosphate ACP dehydratase pyruvate 1-phosphate [protein]-cysteine S- dioxygenase: kinase phospho-N- EO219_RS00845α methyltransferase: photo-lyase: )-methyltransferase aminotransferase: EO219_RS00140 (2E,5Z)- synthase II: fabF synthase II: fabF protein] methyltransferase: -Kdo-(2->4) EO219_RS00160 acyltransferase: PykF: pykF acetylmuramoyl- FabZ: fabZ a cis,cis-delta9,27- a cis,cis-delta9,21- EO219_RS09130 EO219_RS03230 RsmB: rsmB EO219_RS05220 [+ 6 isozymes] phosphoenolpyruvate pyruvate tetradecenoyl-CoA acyl-carrier protein acyl-carrier protein synthase II: fabF EO219_RS09130 -α-Kdo-(2->6) a 2'-deoxycytidine 967 1-palmitoyl-2-EO219_RS06780 pentapeptide- 3-oxo-C46:2-[acp] 3-oxo-C40:2-[acp] a cis,cis-delta19,37- a [protein]-S- acyl-carrier protein a [protein]-S- homogentisate a 5-methylcytosine (2E,7Z)- dGTP pyruvate synthase: kinase acyl-carrier protein a thymine in DNA -(lauroyl)-lipid [DNA] in DNA 3-sulfopyruvate cis-vaccenoyl alanine- transferase: mraY methyl-L-cysteine methyl-L-cysteine in 16S rRNA tetradecenoyl-CoA EO219_RS08005 PykF: pykF UDP-glucose-- UDP-glucose D-glucopyranose 3-oxo-C56:2-[acp] IV (E. coli) phosphatidate -tRNA A ala hexose-1-phosphate 4-epimerase 6-phosphate ligase: undecaprenyldiphospho- a decanoyl-[acp] a 2,3,4-saturated a trans-2-enoyl- pyruvate (3E,5Z)-tetradeca- (S)-3-hydroxy-(5Z) uridylyltransferase: GalE: galE alaS an L-alanyl- N-acetylmuramoyl-L- fatty acyl-[acp] [acyl-carrier protein] 6-(hydroxymethyl) a 5-carboxymethylaminomethyluridine 34 3-phenyl-2- a [pyruvate dehydrogenase a uracil 1939 beta-ketoacyl- 3,5-dienoyl-CoA -tetradecenoyl-CoA EO219_RS07755 [+ 2 isozymes] a cis,cis-delta15,33- maltopentaose 6 2,3- cis-vaccenoyl-CoA γ fructose degradation Leu E2 protein] N - acetoacetyl-CoA [tRNA Ala ] alanyl- -D-glutamyl-meso α-D-glucopyranose a cis,cis-delta5,23-C42:2-[acp] a malonyl-[acp] a cis,cis-delta5,17-C36:2-[acp] a malonyl-[acp] a malonyl-[acp] -7,8-dihydropterin in tRNA oxopropanoate in 23S rRNA [acyl-carrier- UDP-α-D-galactose C52:2-[acp] glycogen/starch/ diaminopropanoate GTP Ala -2,6-diaminopimeloyl- beta-ketoacyl-[acyl- tRNA (cytidine(34) dihydrolipoyl-L-lysine 23S rRNA acyl-CoA 3-hydroxybutyryl- a tRNA protein] 1-phosphate β-D-fructofuranose beta-ketoacyl-[acyl- beta-ketoacyl- 2-amino-4-hydroxy-6- 4-hydroxyphenylpyruvate dihydrolipoamide D-alanyl-D-alanine carrier-protein] -2'-O)- alpha-glucan (uracil(1939)-C(5)) dehydrogenase: CoA synthase 1-phosphate carrier-protein] [acyl-carrier- hydroxymethyldihydropteridine dioxygenase: dehydrogenase: diaminopropionate diguanylate undecaprenyldiphospho- synthase II: fabF methyltransferase: phosphorylase: -methyltransferase EO219_RS00140 dehydrogenase: II: fabF Secondary Metabolite (3E,5Z)- 3-oxo-(5Z)- 1-phosphofructokinase: synthase II: fabF protein] diphosphokinase: folK EO219_RS00160 EO219_RS08925 ammonia-lyase: dpaL cyclase: muramoylpentapeptide beta-N- Respiration a cis,cis-delta7,25- a cis,cis-delta7,19- (7,8-dihydropterin- EO219_RS05485 EO219_RS09995 RlmD: rlmD [+ 6 isozymes] EO219_RS00850 EO219_RS06920 tetradecadienoate tetradecenoyl-CoA pfkB acyl-carrier protein acyl-carrier protein synthase II: fabF α (2-hydroxyphenyl) 1939 (S)-3- acetylglucosaminyltransferase: Biosynthesis D-glucopyranose β-D-fructose 1,6- 3-oxo-C44:2-[acp] 3-oxo-C38:2-[acp] a cis,cis-delta17,35- 6-yl)methyl a 5-carboxymethylaminomethyl- -D-glucopyranose a [pyruvate dehydrogenase pyruvate a 5-methyluracil (2E,11Z)- 34 Leu maltotetraose acetate 6 hydroxybutanoyl- c-di-GMP asparagine-- murG a 3-oxododecanoyl-[acp] 6-phosphate bisphosphate acyl-carrier protein 2'-O-methyluridine in tRNA 1-phosphate E2 protein] N -lipoyl-L-lysine in 23S rRNA octadecenoyl-CoA asn 3-oxo-C54:2-[acp] diphosphate CoA tRNA ligase: lipid II (meso methylerythritol 2-oxoglutarate decarboxylation to succinyl-CoA EO219_RS03500 phosphate pathway I an L-asparaginyl- diaminopimelate a [2-oxoglutarate (3Z)-dodec- Asn [tRNA ] containing) D-glyceraldehyde 3-enoyl-CoA an [apo BCAA dehydrogenase E2 (5R)-5,6-dihydro- (R)-2- Asn pyruvate dehydrogenase a cis,cis-delta11,29- aci-nitroethane maltoheptaose CMP-Kdo lipid IV (E. coli) α-Kdo CTP citrate DNA with lesion tRNA 3-phosphate Secondary Metabolite Degradation pyruvate L-fuculose 1-phosphate 6 A 5-(thymidin-7-yl) hydroxyglutaryl- E2 protein] N 6 a cis,cis-delta3,15-C34:2-[acp] a malonyl-[acp] a malonyl-[acp] protein] N -dihydrolipoyl-L-lysine Nucleoside and Nucleotide Biosynthesis a (3R)-3- dihydrolipoamide C48:2-[acp] L-fuculose-phosphate nitronate glycogen/starch/ 3-deoxy-D-manno- 3-deoxy-manno- thymidine (in DNA) citrate lyase CoA excinuclease 1-deoxy-D-xylulose- -lipoyl-L-lysine pyruvate, phosphate beta-ketoacyl-[acyl- beta-ketoacyl- dihydrolipoamide 2-hydroxyglutaryl- hydroxydodecanoyl-[acp] dehydrogenase: aldolase: EO219_RS11595 monooxygenase: alpha-glucan octulosonic acid octulosonate spore subunit ABC subunit 5-phosphate anhydromuropeptides recycling I dikinase: EO219_RS09320 carrier-protein] [acyl-carrier- dehydrogenase: CoA dehydratase: dihydrolipoamide EO219_RS08925 (2E)-dodec- EO219_RS11145 phosphorylase: transferase: cytidylyltransferase: photoproduct lyase: alpha: citF UvrC: uvrC UMP biosynthesis III xanthine and 3-hydroxyacyl- synthase: synthase II: fabF protein] L-fuculose-phosphate [unspecified EO219_RS08925 EO219_RS06605 superpathway of guanosine superpathway of adenosine pyrimidine deoxyribonucleotides superpathway of pyrimidine guanine and guanosine salvage II dehydrogenase: GlcNAc-1,6- + EO219_RS09995 EO219_RS07835 kdsB EO219_RS03225 aspartate- ACP 2-enoyl-CoA diphosphate AMP phosphoenolpyruvate H a cis,cis-delta5,17- aldolase: EO219_RS08425 α [+ 2 isozymes] [+ 2 isozymes] nucleotides de novo biosynthesis II nucleotides de novo biosynthesis II de novo biosynthesis I nucleobases salvage xanthosine salvage EO219_RS07710 EO219_RS08925 anhMurNAc- acyl-carrier protein synthase II: fabF degradation nitrite acetaldehyde α-D-glucopyranose an [apo BCAA dehydrogenase -Kdo-(2->6)- two adjacent [+ 3 isozymes] DNA without -tRNA dehydratase 3-oxo-C36:2-[acp] a cis,cis-delta13,31- 6 CMP CMP-Kdo oxaloacetate acetate (E)-glutaconyl- asp 1-deoxy-D- a [2-oxoglutarate a [2-oxoglutarate Carboxylate Degradation γ acyl-carrier protein DHAP (S)-lactaldehyde products] maltohexaose E2 protein] N -lipoyl-L-lysine lipid IV (E. coli) thymidines in DNA ligase: hydrogencarbonate gln UDP CTP FabZ: fabZ L-Ala- -D-Glu- 3-oxo-C50:2-[acp] 1-phosphate A CoA lesion uracil xylulose-5- dehydrogenase dehydrogenase aspS an L-aspartyl- ribonucleotide- uracil guanosine xanthosine DAP-D-Ala IMP IMP asp a (2E)-dodec- phosphate E2 protein] N 6 E2 protein] N 6 -S- (S)-3- pyruvate fermentation to acetate IV [tRNA asp ] carbamoyl- diphosphate phosphoribosyltransferase: asp purine-nucleoside 2-enoyl-[acp] synthase: dxs -dihydrolipoyl- succinyldihydrolipoyl- citrate degradation tRNA phosphate reductase: CDP EO219_RS04080 hydroxydodecanoyl-CoA N-acetylmuramoyl- an intrastrand non- N-acetyl-D- a peptide with (2R)-phospho- 1-oleoyl-sn dCDP IMP phosphorylase: deoD L-lysine L-lysine a cis,cis-delta17,29- D-ribulose 1-phosphate ν uroporphyrinogen-III a [protein] Ser/Thr L-β-lysine synthase: adenylosuccinate EO219_RS00225 1-deoxy-D-xylulose pyruvate L-alanine amidase: a (5Z)-tetradec-5-enoyl-[acp] a malonyl-[acp] an acyl-[acyl-carrier protein] a malonyl-[acp] a malonyl-[acp] adjacent cyclobutane h galactosamine an N-terminal 3-sulfolactate -glycerol 3- dehydrogenase: ribonucleotide- UMP purine-nucleoside C48:2-[acp] ribonucleotide- EO219_RS08050 synthase: EO219_RS00230 guanine 5-phosphate an acetyl-holo [citrate EO219_RS01050 L-fuculose-phosphate thymidine dimer in DNA 6-phosphate Xaa-L-proline serine/threonine D-lysine 5,6- phosphate guaB diphosphate UMP kinase: phosphorylase: deoD citrate beta-ketoacyl-[acyl-carrier- beta-ketoacyl-[acyl- beta-ketoacyl- deoxyribodipyrimidine N-acetylglucosamine- leucyl 2-phosphosulfolactate uroporphyrinogen-III 1-acyl-sn-glycerol- diphosphate EO219_RS08055 EO219_RS07845 dUDP lyase acyl-carrier protein] N-acetylmuramoyl- aldolase: EO219_RS11595 protein kinase: aminomutase reductase: EO219_RS01010 xanthine 1-deoxy-D-xylulose- dihydrolipoamide formate C- citrate lyase acyl protein] synthase II: fabF carrier-protein] [acyl-carrier- photo-lyase: 6-phosphate aminopeptidase: phosphatase: C-methyltransferase: 3-phosphate reductase: EO219_RS00225 hypoxanthine 5-phosphate dehydrogenase: 3-oxododecanoyl-CoA carrier protein: citD L-alanine amidase: synthase II: fabF protein] L-fuculose-phosphate EO219_RS03230 deacetylase: nagA EO219_RS05895 EO219_RS09090 cobA EO219_RS02825 subunit alpha: acyltransferase: tyrosine-- carbamoyl asp XMP adenylo-succinate (d)CMP kinase: xanthine a dodecanoyl-[acp] acetyltransferase: acyl-carrier protein a (7Z)-3-oxo-hexadec-7-enoyl-[acp] a DNA with D-galactosamine a peptide with EO219_RS00225 tyr EO219_RS00230 phosphoribosyltransferase: hpt reductoisomerase: EO219_RS08925 [+ 2 isozymes] EO219_RS02760 synthase II: fabF aldolase: EO219_RS08425 acetate a proteinogenic a [protein] (L-serine/L- EO219_RS06870 EO219_RS06780 tRNA ligase: phosphate EO219_RS07830 pflB a citryl-holo [citrate acyl-carrier protein a 3-oxoacyl-[acp] an N-terminal (2R)-3-sulfolactate precorrin-2 (3S,5S)-3,5- EO219_RS00230 xanthine phosphoribosyltransferase: EO219_RS00985 a cis,cis-delta19,31- DHAP glycolaldehyde nonadjacent thymidines 6-phosphate amino acid dioleoyl EO219_RS10810 an L-tyrosyl- glutamine- adenylosuccinate β γ acyl-carrier protein L-proline threonine) phosphate diaminohexanoate CDP dUTP dCDP UDP phosphoribosyltransferase: EO219_RS09005 lyase acyl-carrier protein] N-acetyl- -D- L-alanyl- -D- 3-oxo-C50:2-[acp] phosphatidate Tyr lyase: beta-ketoacyl- [tRNA ] aspartate hydrolyzing glucosamine-1,6- glutamyl-meso-2,6- Tyr dUTP EO219_RS09005 [acyl-carrier- MEP preQ biosynthesis acetyl-CoA formate citrate lyase acyl a tRNA carbamoyltransferase: GMP synthase: EO219_RS03325 0 diphosphatase: decanoyl-CoA anhydro-N-acetyl- diaminopimeloyl- pyrB EO219_RS10975 superpathway of 5-aminoimidazole XMP protein] carrier protein: citD laurate 2-C-methyl-D- phosphate β-D-muramate D-alanine a dimer of adjacent a dimer of adjacent an N-formyl-L- RNase G (5Z)- UDP EO219_RS03155 dCTP ribonucleotide biosynthesis GMP synthase acyl-CoA [+ 2 isozymes] a cis,cis-delta15,27- porphobilinogen a DNA segment AMP UTP erythritol 4-phosphate acetyltransferase: pta a (7Z)-hexadec-7-enoyl-[acp] a malonyl-[acp] a palmitoleoyl-[acp] a malonyl-[acp] a malonyl-[acp] thymidine and 2'- hν pyrimidine hν methionylaminoacyl- VibB coenzyme A degradation dodecenoyl-CoA dUMP II: fabF GTP dehydrogenase: C46:2-[acp] a tRNA precursor CTP ATP ribonucleotide- GMP long-chain fatty oxaloacetate deoxycytidine in DNA nucleosides in DNA tRNA mRNA acyl-CoA N-carbamoyl- PRPP cytidylyltransferase: GTP EO219_RS00140 beta-ketoacyl-[acyl-carrier- beta-ketoacyl-[acyl- beta-ketoacyl- deoxyribodipyrimidine deoxyribodipyrimidine peptide holo-[acyl- recombinase XerD: diphosphate tryptophan- thymidylate acid--CoA ligase: CCA tRNA hydroxymethylbilane dehydrogenase: Trp L-aspartate ispD acetyl phosphate L-alanyl-γ-D- carrier-protein] [acyl-carrier- photo-lyase: photo-lyase: deformylase: carrier-protein] EO219_RS12050 ribonuclease G: reductase: a tRNA adenylate kinase: amidophosphoribosyltransferase: adenine and a 3-oxotetradecanoyl- cyclohydrolase [+ 6 isozymes] 1,6-anhydro-N- protein] synthase II: fabF nucleotidyltransferase: synthase: hemC EO219_RS00140 -tRNA synthase: thyA EO219_RS10160 4-(cytidine 5'- glutamyl-meso- synthase II: fabF protein] EO219_RS03230 EO219_RS03230 def synthase: acpS [+ 3 isozymes] EO219_RS04015 guanylate kinase: EO219_RS01355 EO219_RS08305 CTP adenosine salvage I I FolE: folE acetyl-β-muramate a tRNA EO219_RS09020 a L-methionylaminoacyl- EO219_RS00225 ligase: trpS an L-tryptophanyl- : 5-phospho-β- [acp] [+ 2 isozymes] diphospho)-2-C- diaminopimelate acyl-carrier protein a (9Z)-3-oxo-octadec-9-enoyl-[acp] an (11Z)-3-oxooctadec- synthase II: fabF adjacent thymidine-2'- two adjacent pyrimidine a holo-[VibB aryl- a DNA segment in [+ 6 isozymes] EO219_RS02950 dTMP GTP (2E)-dec-2-enoyl-CoA acetate kinase: acyl-carrier protein containing a formate tRNA preuroporphyrinogen 3',5'-ADP (2E,5Z)- EO219_RS00230 Trp EO219_RS05630 methyl-D-erythritol 11-enoyl-[acp] a cis,cis-delta17,29- deoxycytidine in DNA nucleosides in DNA carrier protein] an mRNA fragment [tRNA ] D-ribosylamine lauroyl-CoA EO219_RS12020 acyl-carrier protein reverse orientation ADP thymidylate kinase: 4-(cytidine 5'- cyclohydrolase 3-oxo-C48:2-[acp] 3' CCA end dodecenoyl-CoA dUDP trp phosphoribosylamine- adenosine 7,8- I FolE: folE (S)-dihydroorotate GDP EO219_RS00980 diphospho) acetate N-acetyl-D- -glycine ligase: purD purine-nucleoside a (3R)-3- dihydroneopterin ribonucleotide- ribonucleotide- dTDP phosphorylase: deoD -2-C-methyl- 3'-triphosphate muramate 6- dihydroorotate hydroxytetradecanoyl- D-erythritol (S)-3- phosphate a dimer of adjacent a dimer of non- N-acetyl-β- β-aspartyl dehydrogenase diphosphate diphosphate GAR guanine and guanosine salvage purine-nucleoside 6-carboxytetrahydropterin hydroxydecanoyl-CoA adenosylcobinamide-GDP α-ribazole a cis,cis-delta13,25- quinoxaline-2- ν ν an N-acylated- a cytosine in DNA precorrin-6B N5-CAIR [acp] kinase: ispE N-acetylmuramic a (5Z)-tetracos-5-enoyl-[acp] a malonyl-[acp] a malonyl-[acp] aryl-carrier protein 2'-deoxycytidine and h adjacent pyrimidine h neuraminate dipeptide ATP threonine- electron ribonucleotide- ribonucleotide- reductase: reductase: phosphorylase: deoD C44:2-[acp] carboxyl adenylate N-acetylneuraminate D-amino acid biotin thr 3-hydroxyacyl- phosphatidylglycerol 2-phospho-4-(cytidine synthase QueD: queD acid 6- adenosylcobinamide-GDP thymidine in DNA nucleosides in DNA beta-aspartyl- DNA (cytosine-5-)- precorrin-6y C5,15- 5-(carboxyamino) -tRNA transfer subunit: diphosphate diphosphate EO219_RS00225 EO219_RS00225 adenine beta-ketoacyl-[acyl-carrier- beta-ketoacyl- acyl carrier protein: deoxyribodipyrimidine deoxyribodipyrimidine lyase: D-aminoacylase: ATP dTTP ACP biosynthesis II (non-plastidic) 5'-diphospho)-2-C- 6-carboxy-5,6,7,8- phosphate ribazoletransferase: cobS peptidase: methyltransferase: biotin--[acetyl-CoA- methyltransferase imidazole reductase: reductase: EO219_RS00230 EO219_RS00230 guanosine protein] synthase II: fabF [acyl-carrier- EO219_RS03995 photo-lyase: photo-lyase: EO219_RS03455 ligase: thrS an L-threonyl- EO219_RS05615 dehydratase methyl-D-erythritol tetrahydropterin etherase: murQ EO219_RS10925 EO219_RS08940 carboxylase] ligase: (decarboxylating) ribonucleotide EO219_RS00225 EO219_RS00225 adenine protein] a quinoxaline-2- EO219_RS03230 EO219_RS03230 N-acetyl-β-D- dcm [tRNA Thr ] GTP purine-nucleoside FabZ: fabZ 3-oxodecanoyl-CoA N-acetyl-D- acyl-carrier protein a (7Z)-3-oxohexacos-7-enoyl-[acp] GMP adenosylcobalamin adjacent 2'-deoxycytidine- a pyrimidine a carboxylate a D-amino acid a proteinogenic EO219_RS09280 : cbiE cbiT mutase: purE EO219_RS00230 EO219_RS00230 FGAR DHAP 2-C-methyl-D- putative 7- synthase II: fabF AMP carboxyl-[aryl- pyruvate asp a 5-methylcytosine biotinyl-5'- a tRNA Thr PRPP orotate dADP phosphorylase: deoD phosphoribosyltransferase: mannosamine amino acid anaerobic a (2E)-tetradec- NAD(P)H- erythritol 2,4- carboxy-7- glucosamine a cis,cis-delta15,27- carrier protein] thymidine in DNA nucleoside in DNA in DNA adenylate precorrin-8x CAIR purine-nucleoside EO219_RS12115 6-phosphate acyl-carrier protein orotate ribonucleoside- CMP phosphoribosylformylglycinamidine 2-enoyl-[acp] dependent glycerol- cyclodiphosphate deazaguanine 3-oxo-C46:2-[acp] phosphorylase: deoD Inorganic Nutrient N-acetylglucosamine- phosphoribosyltransferase: anaerobic triphosphate phosphorylation synthase: EO219_RS08320 3-phosphate synthase: synthase dGDP guanine AMP Metabolism 6-phosphate pyrE ribonucleoside- reductase: nrdD pyrimidine deoxyribonucleotide dehydrogenase: EO219_RS00490 QueE: queE CMP FGAM EO219_RS09770 octanoyl-CoA deacetylase: nagA a dimer of a [peptide] triphosphate phosphorylation 2-C-methyl-D-erythritol- urea cycle 5-amino-4- PRPP a cis,cis-delta11,23- a dimer of adjacent 2'- hν acetyl-CoA an adenine in DNA a uridine in tRNA ser orotidine 5'- (d)CMP kinase: hypoxanthine sn-glycerol 7-carboxy-7- a (4Z)-hexadec-4-enoyl-[acp] a malonyl-[acp] a malonyl-[acp] non-adjacent hν (E)-glutaconate a type IV prepilin met with N-terminal ser serine--tRNA ligase: reductase: nrdD 2,4-cyclodiphosphate acyl-CoA D-glucosamine imidazolecarboxyamide C42:2-[acp] 4'-phosphopantetheine ATP deoxycytidines in DNA phosphate EO219_RS07830 phosphoribosylformylglycinamidine phosphoribosyltransferase: hpt dTMP dCMP 3-phosphate deazaguanine adenine deoxyribodipyrimidine thymidines in DNA glutaconate CoA- β aspartate tRNA EO219_RS11835 an L-seryl- dATP a myristoyl-[acp] dehydrogenase: 6-phosphate beta-ketoacyl-[acyl-carrier- beta-ketoacyl- deoxyribodipyrimidine prepilin peptidase: methionine DNA adenine beta-aspartyl- CDP cyclo-ligase: EO219_RS08300 xanthine thymidylate kinase: (d)CMP kinase: flavodoxin- 7-cyano-7- arg phosphoribosyltransferase: pantetheine-phosphate photo-lyase: transferase subunit dihydrouridine L-serine [tRNA ser ] glycerol-3- phosphoglucosamine protein] synthase II: fabF [acyl-carrier- photo-lyase: EO219_RS01745 gamma- methylase: peptidase: orotidine-5'- phosphoribosyltransferase: EO219_RS00980 EO219_RS07830 dependent (E) deazaguanine EO219_RS00140 : EO219_RS12115 adenylyltransferase: EO219_RS03230 B: EO219_RS09245 synthase ammonia-lyase: a tRNA ser beta-ketoacyl- phosphate 1-O- protein] EO219_RS03230 a cleaved type lyase: megL EO219_RS01635 EO219_RS08940 phosphate AIR dTDP dCDP [+ 6 isozymes] mutase: acyl-carrier protein a (6Z)-3-oxooctadec-6-enoyl-[acp] EO219_RS04020 two adjacent 2'- a peptide EO219_RS10415 dGTP EO219_RS09005 [acyl-carrier- acyltransferase: -4-hydroxy-3- synthase EO219_RS08830 AICAR synthase II: fabF (E)-glutaconyl-CoA acetate an N 6 -methyladenine DusB: dusB decarboxylase: EO219_RS03335 3'-dephospho-CoA deoxycytidines in DNA a thymidine in DNA IV prepilin 2-oxobutanoate methanethiol a peptide asp a 5,6-dihydrouridine protein] plsY methylbut-2-enyl- QueC: queC (2E)-oct-2-enoyl-CoA argininosuccinate ammonium a cis,cis-delta13,25- in DNA pyruvate EO219_RS05625 CTP α-D-glucosamine acyl-carrier protein in tRNA GMP synthase a 1-acyl-sn diphosphate lyase: argH 3-oxo-C44:2-[acp] preQ carbamoyl- 1-phosphate UMP dTTP dCTP II: fabF -glycerol 3- synthase: 0 proline-- pro phosphate EO219_RS04055 phosphate bifunctional UDP-N- tRNA ligase: a 3-oxohexadecanoyl- 1-acyl-sn-glycerol- (E)-4-hydroxy-3- L-arginino- synthase: acetylglucosamine 4-hydroxybutanoyl- D-sedoheptulose (S)-3- L-ornithine adenosylcobyrate (R)-1-aminopropan-2-ol nicotinate a peptide with a coenzyme A NADP + a reduced an α-limit dextrin a folate (S)-malate EO219_RS00535 an L-prolyl- [acp] 3-phosphate methylbut-2-en- succinate EO219_RS08050 diphosphorylase/ a (7Z)-hexacos-7-enoyl-[acp] a malonyl-[acp] an acetyl-[acp] a malonyl-[acp] DL-allothreonine PRPP superoxide penultimate glycine rubredoxin CoA 1-phosphate Pro 1-yl diphosphate hydroxyoctanoyl-CoA EO219_RS08055 glucosamine-1- cobalamin biosynthesis nicotinate CoA-disulfide 4-alpha- class II [tRNA ] acyltransferase: beta-ketoacyl-[acyl-carrier- beta-ketoacyl-[acyl- serine carboxypeptidase: desulfoferrodoxin: 4-hydroxybutyryl- dihydrofolate fumarate a tRNA Pro phosphate N- protein CobD: cobD phosphoribosyltransferase: reductase: glucanotransferase: fructose-1,6- EO219_RS06780 carbamoyl protein] synthase II: fabF carrier-protein] hydroxymethyltransferase: EO219_RS02215 EO219_RS01485 CoA dehydratase: reductase: hydratase: a 1,2-diacyl- acetyltransferase EO219_RS05020 EO219_RS06690 malQ bisphosphate a (3R)-3- phosphate adenosylcobinamide synthase II: fabF EO219_RS07260 a peptide with a an oxidized EO219_RS00310 EO219_RS01265 EO219_RS06895 sn-glycerol GlmU: glmU acyl-carrier protein a (9Z)-3-oxooctacos-9-enoyl-[acp] NaMN an amino acid H + NADPH CoA-disulfide a α-limit dextrin aldolase: fba superpathway of L- Amino Acid Biosynthesis hydroxyhexadecanoyl- argininosuccinate an acetoacetyl-[acp] acyl-carrier protein gly acetaldehyde C-terminal glycine rubredoxin L-cysteine biosynthesis superpathway of L-aspartate glycine biosynthesis I L-phenylalanine 3-phosphate 3-oxooctanoyl-CoA α with short branches crotonyl-CoA a 7,8-dihydrofolate fumarate threonine biosynthesis L-asparagine biosynthesis L-cysteine biosynthesis I [acp] synthase: N-acetyl- -D- D-erythrose DHAP phenylalanine- VI (from L-methionine) and L-asparagine biosynthesis biosynthesis I phosphatidate DMAPP IPP glucosamine III (tRNA-dependent) 3-hydroxyacyl- EO219_RS03190 -tRNA ligase: cytidylyltransferase: L-citrulline 1-phosphate phe oxaloacetate ser ACP EO219_RS01900 met glu chorismate ser EO219_RS00990 RNase III mRNA pyridoxal phosphate- asp serine dehydratase bifunctional UDP-N- a 10- maltopentaose D-glucopyranose a 10- an L-methionyl- 3-aci- [DNA] (S)-4-amino-5- 7,8- EO219_RS01905 methionine chorismate mutase: phosphatidate AICAR processing 2-oxoglutarate a uracil in DNA a tRNA sec ser a tRNA glu formate CTP thr an L-phenylalanyl- dependent fumarate hydroxymethyltransferase: FabZ: fabZ hexanoyl-CoA acetylglucosamine formyltetrahydrofolate formyltetrahydrofolate [initiator tRNA Met ] nitropropanoate oxopentanoate diaminopelargonate Phe adenosyltransferase: EO219_RS09930 cytidylyltransferase: bifunctional 4-alpha- nitronate exodeoxyribonuclease substrate dihydrolipoamide uracil-DNA [tRNA ] aminotransferase: EO219_RS07260 diphosphorylase/ methionyl-tRNA ribonuclease serine--tRNA ligase: glutamyl-tRNA anaerobic dethiobiotin Phe pyridoxal phosphate- a (2E)-hexadec- EO219_RS06785 phosphoribosylaminoimidazolecarboxamide glucanotransferase: malQ monooxygenase: dehydrogenase: glycosylase: threonine a tRNA EO219_RS05220 EO219_RS05700 gly prephenate O-acetyl-L-serine acyl-CoA glucosamine-1- formyltransferase: III: xth EO219_RS11835 reductase: ribonucleoside- synthase: dependent aspartate 2-enoyl-[acp] formyltransferase/IMP cyclohydrolase: purH EO219_RS11145 a 2'- III: rncRNase III EO219_RS08925 EO219_RS01675 ammonia-lyase: asp SAM a CDP- dehydrogenase: phosphate N- maltose maltotetraose an N-formyl- EO219_RS12145 [unspecified an L-seryl- hemA triphosphate bioD aminotransferase: ammonia-lyase: deoxyribonucleoside [DNA] an mRNA fragment processing an apyrimidinic EO219_RS11680 an L-aspartyl- O-acetylhomoserine diacylglycerol EO219_RS00140 acetyltransferase FAICAR a tetrahydrofolate NADH CO succinyl-CoA uracil sec Glu reductase: nrdD L-methionyl- a tetrahydrofolate degradation nitrite 3-oxopropanoate 5'-monophosphate 2 site in DNA [tRNA ] an L-glutamyl-[tRNA ] Asn EO219_RS05220 EO219_RS05390 mRNA dethiobiotin [tRNA ] aminocarboxypropyltransferase/ CDP-diacylglycerol-- [+ 6 isozymes] GlmU: glmU met products] dCTP 2-oxobutanoate aspartate kinase: [initiator tRNA ] gln cysteine synthase: glycerol-3-phosphate 3- met methionine- EO219_RS05170 Asp-tRNA(Asn) 3-phenyl-2- UDP-N-acetyl- EO219_RS03730 trans-hex-2-enoyl-CoA α -tRNA /Glu-tRNA(Gln) asp L-methionine biosynthesis III oxopropanoate a palmitoyl-[acp] phosphatidyltransferase: -D-glucosamine an L-methionyl- glutaminase a dimer of non-adjacent a long-linear β ligase: metG L-aspartyl- SAH amidotransferase: pyridoxal phosphate- pgsA UDP-N-acetylglucosamine 5,10-methylene- 3-methyl-2- maltohexaose D-glucopyranose phosphoenol an [HPr]- α-D-glucopyranose a dimer of adjacent ν a glucan maltotriose -D-fructofuranose O-ureido-L- [elongator A: glsA cys 1-(3-sn- 2'-deoxycytidine and hν α-D-glucan h a ribonucleic acid asp formate UTP 5-aminolevulinate NADH 4-phosphate gatC gatA gatB aspartate-- dependent 1-carboxyvinyltransferase: tetrahydromethanopterin oxobutanoate pyruvate L-histidine thymidines in DNA 1-phosphate homoserine elongator Met 3-methyl-2-oxobutanoate 4-alpha- phosphoenolpyruvate- 4-alpha- deoxyribodipyrimidine 4-alpha- class II fructose- tRNA ] 5'-methylthioadenosine/ a 4-phosphooxy- [+ 4 isozymes] L-homoserine S-adenosyl-L-methionine cycle I phosphatidyl) murA thymidine in DNA deoxyribodipyrimidine ribonuclease argininosuccinate anaerobic NAD(+)/ tRNA Met ammonia ligase: aminotransferase: hydroxymethyltransferase: glucanotransferase: malQ -protein glucanotransferase: photo-lyase: glucanotransferase: 1,6-bisphosphate porphobilinogen aspartate- adenosylhomocysteine L-aspartyl- -sn-glycerol (S)-3- α photo-lyase: PH: rph synthase: ribonucleoside- NADH kinase: ammonium EO219_RS09070 EO219_RS05220 UDP-N-acetyl- - malQ malQ synthase: hemB semialdehyde nucleosidase: Asn ammonia 3-phosphate hydroxyhexanoyl-CoA panB maltose maltopentaose phosphotransferase: ptsP EO219_RS03230 a nucleoside aldolase: fba [tRNA ] SAM palmitate D-glucosamine- EO219_RS03230 an [HPr protein]- a short 1,4- two adjacent a ribonucleic acid EO219_RS03190 triphosphate EO219_RS00880 dehydrogenase: EO219_RS00840 O-acetyl-L- assimilation cycle III THMPT 2-dehydropantoate a 2'-deoxycytidine π α D-glucopyranose a glucan diphosphate D-glyceraldehyde DHAP asn hydrogen sulfide phe phosphatidylglycerophosphatase enolpyruvate a thymidine in DNA N -phospho- pyruvate -D-glucan thymidines in DNA canavaninosuccinate reductase: nrdD EO219_RS05165 homoserine in DNA dUTP porphobilinogen NADPH lysine- S-ribosyl-L- Asp-tRNA(Asn) long-chain fatty A: EO219_RS05290 UDP-N- L-histidine Lys a tRNA -tRNA L-aspartate 4- homocysteine /Glu-tRNA(Gln) asparaginase: O-acetylhomoserine methionine ammonium glu acid--CoA ligase: an L-1- acetylmuramate semialdehyde amidotransferase: EO219_RS08120 aminocarboxypropyltransferase/ adenosyltransferase: glutamine EO219_RS10160 phosphatidyl- 3-oxohexanoyl-CoA ligase: lysS an L-lysyl- dehydrogenase: UDP-N-acetyl-α-D-muramoyl- a dimer of non-adjacent a plant soluble a DNA containing D-ribulose gatC gatA gatB EO219_RS05700 synthetase type III: a maltodextrin D-glucopyranose D-glucopyranose 7,8-dihydrofolate + a [protein] N-terminal- 2+ + Lys L-glutamate cysteine synthase: [+ 2 isozymes] sn-glycerol D-alanyl-D-alanine ν acetyl-CoA (R)-2-hydroxyglutarate NADPH H protoporphyrin IX Mg a tripeptide NAD + + [tRNA ] homoserine murB L-alanyl-γ-D-glutamyl-L-lysine thymidine and 2'- h heteroglycan monoglutamate an apurinic/ formyl-L-methionine tyr 5-phosphate H RS03370 H biosynthesis III EO219_RS03730 EO219_RS01540 4-alpha- 4-alpha- lys dehydrogenase: asp palmitoyl-CoA UDP-N-acetyl- UDP-N-acetylmuramoyl- deoxycytidine in DNA deoxyribodipyrimidine glutaconate CoA- dihydrofolate apyrimidinic site peptide magnesium peptidase tyrosine ribulose-phosphate NAD(+)/ an L-asparaginyl- met SAH gln α glucanotransferase: endonuclease EO219_RS05175 -D-muramate tripeptide--D-alanyl-D- glucanotransferase: malQ transferase subunit reductase: deformylase: def chelatase: T: pepT 3-epimerase: L-homocysteine 2-oxoglutarate Asn L-homocysteine photo-lyase: III: nth phenol-lyase: NADH kinase: [tRNA ] 5'-methylthioadenosine/ maltose a maltodextrin B: EO219_RS09245 malQ EO219_RS01265 a 5'-phospho- an N-terminal L- EO219_RS10750 NADPH- alanine NADPH-dependent butanoyl-CoA α alanine ligase: murF EO219_RS03230 a plant soluble a 3'-terminal formate a dipeptide a proteinogenic EO219_RS05320 EO219_RS11755 EO219_RS00880 L-homoserine adenosylhomocysteine UDP-N-acetyl- -D-muramoyl-L-alanyl- + 5,6,7,8- Mg- a 2'-deoxycytidine (R)-2-hydroxyglutaryl-CoA acetate maltose NADP [DNA] unsaturated sugar methionyl-[protein] amino acid D-xylulose racemization 5-methyltetrahydrofolate- 5-methyltetrahydrofolate- glutamate γ a thymidine in DNA heteroglycan pyruvate phenol + dependent 5-methyltetrahydrofolate- nucleosidase: acyl-CoA -D-glutamyl-L-lysyl-D-alanyl-D-alanine in DNA tetrahydrofolate protoporphyrin NADP histidine-- glutamate -homocysteine -homocysteine -homocysteine synthase: gltA UDP-N-acetyl- 5-phosphate his homoserine kinase: L-alanine EO219_RS00840 dehydrogenase: tRNA ligase: synthase: ala methyltransferase: methyltransferase: methyltransferase: α-D-muramoyl- EO219_RS05185 biosynthesis III glu EO219_RS00140 EO219_RS05535 an L-histidyl- gltA alanine racemase: EO219_RS10045 EO219_RS10045 EO219_RS10045 S-ribosyl-L- L-alanyl-γ-D- L-cystathionine L-homocysteine [+ 6 isozymes] a single- a 5S rRNA D-sedoheptulose D-glyceraldehyde RNase R degradation D-erythrose D-xylulose a dipetide with an N- His EO219_RS00810 homocysteine glutamyl-meso-2,6- maltotetraose D-glucopyranose a single a ribonucleoside canavaninosuccinate L-canavanine SAICAR [tRNA ] O-phospho- glu CAIR asp stranded RNA 7-phosphate 3-phosphate substrate RNA 4-phosphate 5-phosphate terminal L-aspartate KDO-8P His cys met precursor stranded DNA triphosphate a tRNA L-homoserine alanine crotonyl-CoA diaminopimelate 4-alpha- polyribonucleotide transketolase: ribonuclease transketolase: arginase: adenylosuccinate dipeptidase cysteine phosphoribosylaminoimidazolesuccinocarboxamide ribonuclease DNA primase: argininosuccinate HAD-IIIA family threonine racemase: alr glucanotransferase: malQ nucleotidyltransferase: pnp M5: rnmV EO219_RS00900 R: rnr EO219_RS00900 lyase: argH EO219_RS08830 lyase: PepV: pepV desulfurase synthase: EO219_RS08310 D-xylulose D-ribose 5- EO219_RS00960 D-glyceraldehyde hydrolase: synthase: D-ala maltose maltotriose a nucleoside a single- a double-stranded a nucleoside 5'- ssDNA/pppN(pN) EO219_RS03325 a proteinogenic NifS: nifS SAICAR a mature 5S-rRNA 5-phosphate phosphate a diribonucleotide 3-phosphate F6P fumarate L-canavanine urea L-canaline asp EO219_RS01065 EO219_RS05180 diphosphate stranded RNA oligonucleotide monophosphate hybrid AICAR fumarate amino acid cys ala n -1 α-Kdo gly glycine--tRNA (S)-3- ligase: glyQ thr hydroxybutanoyl-CoA EO219_RS09840 a glycyl-[tRNA Gly ] a tRNA Gly acetoacetyl-CoA

acetyl-CoA C- acetyltransferase: methionine- met EO219_RS09950 -tRNA ligase: metG an L-methionyl- acetyl-CoA [initiator tRNA Met ] initiator tRNA Met

a 2,3,4-saturated fatty acyl CoA a 2,3,4-saturated fatty acyl CoA a 2,3,4-saturated fatty acyl CoA cis-vaccenoyl-CoA cis-vaccenoyl-CoA cis-vaccenoyl-CoA

RS11235 RS07375 RS10160

a 2,3,4-saturated fatty acid a 2,3,4-saturated fatty acid a 2,3,4-saturated fatty acid cis-vaccenate cis-vaccenate cis-vaccenate

This diagram was automatically generated by SRI International Pathway Tools version 25.0, authors S. Paley and P.D. Karp.