Cell Biology, Members in the News 8 Disparities Research in Has Been Named Member Gifts 8 HIV, to Present the 15Th by ASCB Public Policy Briefing 9 Annual E.E

ASCB AUGUST 2008 NEWSLETTER VOLUME 31, NUMBER 8 Making Expanding Scientific Exchange, Education a Priority Building Capacity Page 2 Involving more members in the ASCB’s programs was one focus of the June 19, 2008, meeting of the Society’s International Affairs Committee (IAC). The meeting, held in Bethesda, MD, A New ASCB also addressed IAC goals and related activities: Education n Promoting scientific exchange internationally n Building scientific capacity worldwide Initiative n Supporting international ASCB members in their scientific endeavors Page 12 Promoting Scientific Exchange IAC Co-Chairs Mary C. Beckerle and Bruce M. Alberts, ASCB Past President, welcomed The Science Committee members Dacheng He, Cynthia G. Jensen, J. Richard (Dick) McIntosh, Mahasin A. Osman, Mark Peifer, and David S. Roos; and staff members Trina Armstrong, Howie Berman, Mentoring Thea Clarke, David Driggers, Dave Ennist, Joan Goldberg, and Alison Harris for all or part of Paradox the meeting. Beckerle reported on: n The 2007 ASCB Council Roundtable, where approximately 200 U.S. and international graduate Page 19 students discussed with ASCB Council members and staff how the Society could help them See IAC, continued on page 6 Inside Hildreth Named Gall to Present President’s Column 2 Alberts Award 7 E.E. Just Lecturer Porter Lecture MBC Paper of the Year 7 The ASCB Minorities Affairs Committee has Joseph Gall of the Carnegie Institution Public Service Award 8 named James Earl King Hildreth, Director of the of Washington, a founder of the field Meharry Center for Health of cell biology, Members in the News 8 Disparities Research in has been named Member Gifts 8 HIV, to present the 15th by ASCB Public Policy Briefing 9 annual E.E. Just Lecture. President Robert Sharing Classroom Resources 12 Hildreth is also Professor D. Goldman in both the Department of to give the Dear Labby 14 Internal Medicine and the 27th Keith R. ASCB Profile 15 Department of Biomedical Porter Lecture. WICB Column 19 James Earl King Sciences at Meharry Medical Joseph Gall His lecture, Hildreth College. “Through the InCytes from MBC 21 Hildreth is being Looking Glass,” focusing on progress PIC Associates Wanted 22 recognized for his pioneering contributions in in our understanding of chromosome Did You Know...? 22 the field of AIDS research. His research focuses structure and function during the 48 on cholesterol’s role in allowing HIV to penetrate years since the founding of the ASCB, ASCB Staff Scientist Wanted 23 cells. Hildreth will speak on Sunday, December will be presented during the 48th Annual Meeting Program 24 13, 2008, at the ASCB Annual Meeting in San Annual Meeting in San Francisco on Grants & Opportunities 26 Francisco, CA. n December 16, 2008. n Calendar 28 The American Society for Cell Biology PRESIDENT’S Column 8120 Woodmont Avenue, Suite 750 Bethesda, MD 20814-2762 Tel: (301) 347-9300 Fax: (301) 347-9310 Making Education a Priority [email protected], www.ascb.org How to convey to students the excitement of popular and interactive question and answer Joan R. Goldberg Executive Director our field? That’s the challenge faced by the period. The poster session that follows is, for ASCB Education Committee (EdComm). most undergraduate participants, the first such Officers This month I am highlighting the Committee’s experience at an international scientific meeting. important activities as part of my continuing As then Lake Forest College student Mithaq Robert D. Goldman President effort to convey to the membership the Vahedi (an ASCB EdComm undergraduate Brigid Hogan President-Elect remarkable array of ASCB activities. The travel awardee now at Jefferson Medical College) Bruce Alberts Past President importance of our educational activities is recalls, “The ASCB meeting gave me a sense Gary E. Ward Treasurer Jean E. Schwarzbauer Secretary underscored by the results of a of belonging to the scientific recent ASCB member survey; community [and]…is unlike Council it revealed that the majority any other meeting I have of respondents named science attended.” John S. Condeelis education a top priority for the Other ASCB Annual Susan K. Dutcher Society. Meeting activities include D. Scott Emr Joan R. Goldberg, ex officio EdComm Chair Tim an Education Workshop, a Holly V. Goodson Stearns of Stanford and ASCB three-hour session targeting Kathleen J. Green Editorial and Education Senior undergraduate educators. The Sandra K. Masur Manager Thea Clarke work wide range of topics covered in Barbara J. Meyer with Committee members recent years include scientific Timothy J. Mitchison who represent all levels of teaching methods and the use of Anne J. Ridley Paul W. Sternberg the educational process: “clickers” (classroom tools that Clare M. Waterman K–12, undergraduate, enable the educator’s immediate Susan R. Wente graduate, and postdoctoral. assessment of student We seek representation on Bob Goldman understanding; for information The ASCB Newsletter is published twelve times per the Committee from liberal on clicker questions, visit year by The American Society arts colleges, research universities, community http://bioeducate.ascb.org/conceptquestions. for Cell Biology. colleges, high schools, and science museums (see html). This year the Education Workshop will Committee roster and affiliations on page 4). focus on quantitative modeling in cell biology. Joan R. Goldberg Editor W. Mark Leader Editor Rounding out EdComm’s Annual Meeting Elizabeth M. Rich Production Manager Annual Meeting Educational programming are Education Initiative Forums: Nancy Moulding Prod. Coordinator Programs three presentations selected from education Kevin Wilson Public Policy Director Committee activities are numerous, and abstracts submitted for presentation at the Ed Newman Advertising Manager many are focused on educational events at our Annual Meeting. (Reminder: This year’s John Fleischman Science Writer Thea Clarke Editorial Manager Annual Meeting. For the 48th ASCB Annual deadline for poster consideration only for all Meeting, in San Francisco this year, EdComm submissions is September 3rd; for late abstracts: Deadlines for submission of will sponsor a K–12 Science Education October 16th.) The Education Initiative Forums articles and advertising Partnership Lunch. Although food is served, are held Monday–Wednesday from 9:45–10:15 materials: the main purpose of this gathering is a hands- am, the time slot between the major scientific on workshop for local high school teachers. symposia. Issue Deadline October September 1 These teachers are also offered free registration EdComm also organizes an Educational November October 1 to attend the entire Annual Meeting. ASCB Resources Booth at the meeting that highlights December November 1 members who want to learn new techniques additional cell biology education materials. ASCB Newsletter for teaching science are also welcome to attend. Interested ASCB members and others can ISSN 1060-8982 Recent topics have ranged from introducing examine recent educational materials including Volume 31, Number 8 biotechnology in the classroom to the use of books and CDs produced by the National August 2008 tactile teaching models. This year the program Academy of Sciences and Howard Hughes © 2008 will address exploring cells without microscopes. Medical Institute. Attendees can also obtain The American Society for Cell Biology EdComm also co-sponsors an Undergraduate copies of the Highlights issue of CBE—Life Program in conjunction with a poster session. Sciences Education (CBE-LSE). The booth also Postmaster: Send change of address to ASCB Newsletter This program is kicked off with a one-hour features scheduled presentations, highlighted The American Society for Cell Biology 8120 Woodmont Avenue, Suite 750 lecture on Saturday afternoon followed by a in the ASCB Program Book. Committee Bethesda, MD 20814-2762

2 ASCB NEWSLETTER AUGUST 2008 members and ASCB staff and Women in Cell Biology are available at the booth to Committee select the award provide information about ...the majority of winner. Traditionally the award ASCB’s growing collection of [ASCB member] is presented by the EdComm digital educational resources, Chair on the Sunday of the such as iBioSeminars, the respondents named meeting, followed by a talk Image & Video Library, and science education presented by the awardee. BioEDUCATE. This year we recognize Wm. EdComm administers one a top priority for David Burns and Karen of the Society’s Travel Award the Society. K. Oates, founders of the programs for undergraduate, Science Education for New predoctoral, and postdoctoral Civic Engagements and Tim Stearns students to attend the Annual Responsibilities (SENCER) Meeting. Each summer Committee members program (see page 7). volunteer to review hundreds of travel award applications, letters of recommendation, and ASCB Digital Resources abstracts. Last year, a total of 112 students and Besides the incredible amount of work required postdocs were selected by EdComm members to to oversee the activities at the Annual Meeting, receive travel awards to attend the ASCB Annual EdComm members and Clarke keep busy with Meeting in Washington, DC. many other tasks throughout the year. For An additional 60 travel awardees at all career example, the Committee works closely with the stages were selected by the Minorities Affairs Editorial Board of the ASCB’s journal CBE— Committee (MAC); these were funded by a Life Sciences Education (www.lifescied.org). National Institutes of Health Minority Access to Some EdComm members also serve on the Research Careers grant. Editorial Board of the journal, and Editor-In- Claudio Aguilar, a minority junior faculty Chief Bill Wood serves as an ex officio member member at Purdue and 2007 MAC travel of EdComm. awardee, wrote, “2007 ASCB was inspirational EdComm was charged by Council to and extremely helpful. Inspirational because improve the “Educational Resources” link on past year talks, particularly Dr. Elma Gonzalez’s, the ASCB website. This link will shortly be further reinforced the determination to face replaced by the new ASCB BioEDUCATE the challenges that we all face in order to do website (http://bioeducate.ascb. science nowadays. Helpful because the insightful org). BioEDUCATE will move comments we received at the poster session current cell biology research allowed us to refine the work that materialized findings into the undergraduate in the first manuscript produced by our new classroom as quickly as possible. lab!” Beautiful images, diagrams, The transition from postdoc to career and movies will help introduce positions in academia or industry can be new cell biological findings and difficult, and EdComm’s Subcommittee for concepts, as well as provide Postdoctoral Training (SCOPT) aims to help. tools for educating students Last year’s SCOPT-sponsored Annual Meeting about the “basics.” ASCB presentation emphasized careers outside Director of Digital Resources academia. It was a smashing success, with 200 in Dave Ennist has taken the lead attendance. A similar panel presentation will be on conceptualizing, creating, sponsored by SCOPT this year in San Francisco. and growing the site. The 2008 panel will showcase a liberal arts Editing the BioEDUCATE professor, science writer, intellectual property website is the responsibility lawyer, and representatives from a biotech of several EdComm company and a science museum. subcommittees. These The ASCB Bruce Alberts Award for Excellence include the Active Learning in Science Education is also presented each year Resources Subcommittee at the ASCB Annual Meeting. The EdComm (Karen K. Kalumuck, Triscia chair, a member of the Executive Committee, and W. Hendrickson, Maria The spring issue of CBE-LSE focused on developmental the chairs of the Minorities Affairs Committee L. Niswonger, and Heidi G. biology education. AUGUST 2008 ASCB NEWSLETTER 3 Elmendorf). Its mission: to provide guidance on More Outreach to Teachers the use of the wide array of non-ASCB biology EdComm also reaches out to state and local learning resources available on the Internet. school systems by sponsoring a booth and a The Concept Questions scientific presentation at the The transition Subcommittee (Shubhik K. National Association of Biology from postdoc to DebBurman, Alison E.M. Teachers (NABT) Annual Adams, Susan M. Wick, Samuel Meeting. Staffed by Clarke, the BioEDUCATE will career positions C. Silverstein, and Wood) booth offers information about in academia or oversees the development of move current cell the ASCB and free educational an archive of educator-tested biology research materials. A scientific talk industry can questions—the ASCB Concept on “Current Topics in Cell be difficult, Question Archive—for faculty findings into the Biology” is always presented by to use while lecturing. (To and EdComm’s undergraduate an ASCB member who teaches submit your question, visit in the vicinity of the meeting Subcommittee http://bioeducate.ascb.org/ classroom as location. for Postdoctoral conceptquestions.html. For quickly as possible. This multitude of exciting more information, see page 12.) activities requires volunteers. Training (SCOPT) The CBE-LSE Resources Recently 12 ASCB members aims to help. Subcommittee (Kimberly D. volunteered to help the Tanner, Robin L. Wright, Ernest Committee in various capacities L. Schiller, and Caroline M. Kane) is considering in response to a call for volunteers in the ASCB ways to make the content of the journal more Newsletter. Plans are under way to involve these accessible to educators; and the Annotations volunteers, soon to be designated Education Subcommittee (Elisa M. Konieczko, Shawn A. Committee Affiliates, in the development of the Galdeen, Melanie L. Styers, and Stearns) reviews BioEDUCATE site. annotations for images and videos that are useful I wish to thank Stearns, who has done a to cell biology students. wonderful job as Chair over the past few years. Stearns will step down at the end of the year and Caroline M. Kane, of the University of 2008 Education Committee California, Berkeley, has kindly agreed to take over the reins from 2009–2011. Kane, a former Tim Stearns (Chair), Stanford University Council member, has already become immersed Alison E.M. Adams, North Arizona University in the BioEDUCATE project. n Shubhik K. DebBurman, Lake Forest College Comments are welcome and should be sent to Heidi G. Elmendorf, Georgetown University [email protected]. Triscia W. Hendrickson, Morehouse College Karen E. Kalumuck, Exploratorium Teacher Institute Elisa M. Konieczko, Gannon University Kenneth R. Miller, Brown University Maria L. Niswonger, York County Community College Lynne M. Quarmby (WICB Liaison), Simon Fraser University Mark D. Rose, Princeton University Ernest L. Schiller, Retired High School Teacher Samuel C. Silverstein, Columbia University College of Physicians & Surgeons Kimberly D. Tanner, San Francisco State University Susan M. Wick, University of Minnesota William B. Wood (ex officio), University of Colorado Robin L. Wright, University of Minnesota Melanie L. Styers (ad hoc, SCOPT Co-Chair), University of Alabama-Birmingham Shawn A. Galdeen (ad hoc, SCOPT Co-Chair), University of Massachusetts Medical School

4 ASCB NEWSLETTER AUGUST 2008

IAC, continued from page 1 The IAC addressed future sites, equipment donation, and how to involve more ASCB n The 2008 ASCB Council Roundtable, which members in the workshops. McIntosh will extend discussion with a presentation proposed a subgroup on African outreach by Patrick Duffy of the Seattle Biomedical in cell biology at the 2008 ASCB Annual Research Institute (SBRI) on pregnancy Meeting. Beckerle proposed linking a 2011 The ASCB Facebook malaria international, ASCB co-sponsored summer page—aimed at n The ASCB Facebook and LinkedIn pages meeting topically with the 2010 African graduate students— (visit www.ascb.org to join): The former— workshop. aimed at graduate students—already has already has nearly nearly 200 members, while the latter—aimed Supporting Scientific Endeavors 200 members... at more established scientists—numbers Ennist provided an overview of the new ASCB approximately 100. digital resource, BioEDUCATE (see President’s n Interest in developing an ASCB Graduate Column, page 2): Council or otherwise involving graduate n This website’s users are 50% international, students in IAC work although 25% of ASCB members are n The possibility of an ASCB Annual Meeting international. student lounge (being planned) n ASCB Education Committee members have Jensen and Driggers provided an established subcommittees to assist with iBioSeminars (www.ascb.org/ibioseminars) vetting contents, including undergraduate- update on behalf of Ron Vale, who developed level annotations of Image & Video Library the ASCB open-access, online seminar series (IVL) contents, concept questions, and other (funded in part by the Howard Hughes Medical active learning resources. Institute): Osman described the New York Academy’s n The 20 seminars launched in 2008 should be new Scientists Without Borders (SWB) augmented with 13 additional seminars in website (scientistswithoutborders.nyas. 2008. org). ASCB has both institutional and n There have been 220,000 downloads and programmatic profiles there. SWB’s goal is to visitors from 115 countries to date. match resources with needs in the developing n Driggers is working to place iBioSeminars on world. iTunes U. Peifer and Harris reported on the 2009 n Subtitles and translations are needed, as are ASCB–Japanese Society for Cell Biology–Riken wider dissemination and additional publicity CDB co-sponsored meeting: and funds. n The title is: “Building the Body Plan: How Peifer and Osman reported on pending IAC Cell Adhesion, Signaling, and Cytoskeletal Newsletter columns, and IAC members discussed Regulation Shape Morphogenesis.” new topics. n It will be held September 21–23, 2009, in Kyoto, Japan. Building Scientific Capacity n Speaker invitations were issued, and grant McIntosh discussed the ASCB’s first African applications are in process. workshop, sponsored by ASCB’s three-year grant Jensen added that she is developing an from the Carnegie Foundation of New York: ASCB international education session for the n A collaboration with faculty at Sokoine International Congress on Cell Biology in South University, Morogoro, Tanzania, and SBRI Korea, October 7–10, 2008. And Beckerle n Two hundred students applied; 25 were concluded by noting that there will be January selected for travel grants and admission. 2009 IAC openings. Interested ASCB members n Follow-up courses to include two in 2009 should write [email protected]. n (Ghana and Tanzania) and one in 2010 —Joan Goldberg and Howie Berman, ASCB (Tanzania) Senior Manager, Technology & Member Services

6 ASCB NEWSLETTER AUGUST 2008 Burns and Oates to Receive Alberts Award

In recognition of the n SENCER Backgrounders that provide high- tremendous impact of quality syntheses of complex, civic issues to their innovative program, connect what is known and unknown with Science Education for what is at stake for society New Civic Engagements n Science Education and Civic Engagement: and Responsibilities An International Journal, a new Web-based, (SENCER), Wm. David peer-reviewed journal published by NCSCE Burns and Karen K. Oates that explores connections between science Wm. David Burns will receive the ASCB education and civic engagement Bruce Alberts Award for n Seventy-six SENCER Leadership Fellows, Excellence in Science appointed in July 2008, who, in addition Education on December to being honored for their contributions to 14, at the 2008 Annual SENCER, will undertake projects and engage Meeting in San Francisco. in activities to expand the impact of the Burns and Oates program founded SENCER in 2001 Burns is currently the Executive Director of to engage student interest NCSCE and a professor of general studies at by focusing coursework on Harrisburg University of Science and Technology. Karen K. Oates real-world problems. Since Oates, who was a faculty member and dean at its inception, the program George Mason University when the SENCER has attracted the formal participation of over program was initiated, served as founding provost 1,300 educators, administrators, and students at Harrisburg until August 2007. She is now with from 330 colleges, universities, high schools, the Division of Undergraduate Education, NSF. and governmental and nongovernmental For more information about the program, visit organizations concerned with improving science, www.sencer.net. n technology, engineering, and mathematics —Thea Clarke education. These individuals and institutions have participated in SENCER events and/ or launched projects on their campuses. The Grishchuk to Receive program has been supported by the National Science Foundation (NSF). Each year, SENCER and the National Center MBC Paper of the Year for Science and Civic Engagement (NCSCE) at Harrisburg University of Science and Award Technology offer: n An intensive residential Summer Institute Ekaterina L. Grishchuk, of the Department of Molecular, n National and regional symposia Cellular, and Developmental Biology at the University of n Workshops on innovative pedagogies, Colorado at Boulder, was named by campus visits, assessment resources, and the Molecular Biology of the Cell (MBC) publications Editorial Board as recipient of the The SENCER program encompasses: 17th annual MBC Paper of the Year n Five Centers for Innovation that provide Award. As a postdoctoral fellow in J. strong regional networks to support alumni Richard (Dick) McIntosh’s laboratory, and those new to SENCER and to encourage Grishchuk co-authored the article interinstitutional collaborations “Mitotic Chromosome Biorientation n Field-tested courses and programs that Ekaterina L. Grishchuk in Fission Yeast Is Enhanced by Dynein exemplify the SENCER approach; new and a Minus-end–directed, Kinesin- models are added annually like Protein” (Mol. Biol. Cell 18, 2216–2225) with Ilia S. Spiridonov and McIntosh. Grishchuk will present her research at a minisymposium at the ASCB Annual Meeting in San Francisco this December. n

AUGUST 2008 ASCB NEWSLETTER 7 Singer to Receive MEMBERS in the News David J. Asai of Harvey Mudd College, an ASCB 2008 ASCB Public member since 1979, has been named Undergraduate Science Education Program Director at the Howard Service Award Hughes Medical Institute. Mark Harmel for HHMI At its May meeting, the ASCB Public Policy Committee selected Maxine F. Singer to receive the 2008 ASCB Public Bonnie Bassler of Princeton University/HHMI, an ASCB Service Award. In announcing Singer’s member since 2003, will give a talk in the new Woods selection, ASCB Public Policy Committee Hole lecture series, Distinctive Voices@The Jonsonn Chair Tom Pollard called her “one of the Center, on “Chemical Conversations: How Bacteria Talk to Each Other.” foremost public citizens of science for over 30 years.” Singer, a longtime member of the Wolfgang P. Baumeister of Max Planck Institute for ASCB, was one of the organizers of Biochemistry, an ASCB member since 1997, has been Maxine F. Singer the Asilomar Conference in 1975 that awarded the Carl Zeiss Lecture and Prize from the established a framework for the conduct German Society for Cell Biology and the Bijvoet Medal of recombinant DNA research. She was one of the five signers from the University of Utrecht, The Netherlands. of the summary statement that established guidelines for the research. As chair of the National Research Council’s Committee Richard B. Marchase of the University of Alabama at Birmingham, who joined the ASCB in 1980, became the on Science, Engineering and Public Policy, Singer focused 93rd President of the Federation of American Societies on graduate education, postdoctoral scholarship, women in for Experimental Biology (FASEB) on July 1, 2008. science, and scientific conduct. Throughout her career, Singer has been interested in the interaction between science and public policy, particularly those areas with moral and ethical implications. She also served as the president of the Carnegie M. Bishr Omary of Stanford University, an ASCB Institution from 1988 to 2002. member since 1991, will become Chair of the The award will be presented at the ASCB Annual Meeting Department of Molecular and Integrative Physiology at on December 14 at 7:00 pm in the Moscone Center in San the University of Michigan Health System. Francisco. n —Kevin M. Wilson Allan C. Spradling of the Carnegie Institution/HHMI, who joined the ASCB in 1991, was the recipient of the Gruber Genetics Prize and gold medal at the Upcoming Events International Congress of Genetics in Berlin. Coalition for the Life Sciences

September 17 Congressional Biomedical Research Caucus n Pharmacogenomics: Personalizing Therapies Speaker: Kathleen M. Giacomini, University of California, San Francisco MEMBER Gifts September 24 Congressional Biomedical Research Caucus The ASCB is grateful to the following member applicants n Checklists and Their Impact on Medical Care who have recently given a gift to support Society activities: Speaker: Peter Pronovost, Johns Hopkins University School of Medicine Roselyn J. Eisenberg Erin Alisa Jimenez Kevin Sohail Kolahi www.coalitionforlifesciences.org

8 ASCB NEWSLETTER AUGUST 2008 PUBLIC POLICY Briefing Harkin, Specter Introduce $5.2 Billion NIH Bill

Senators Tom Harkin (D-IA) and Arlen Specter years of flat funding for the NIH “a scandalous (R-PA) have, once again, shown why they are situation.” the National Institutes While there is of Health’s (NIH) best little chance the friends in Congress. bill will become Harkin and Specter law this late in the have joined together legislative session, to introduce a bill it is the strongest that would provide signal to date that the NIH with an NIH supporters in additional $5.2 billion Congress understand for FY2008. The the critical situation bill would provide NIH-funded the National Cancer researchers are in now. Sen. Tom Harkin (D-IA) Sen. Arlen Specter (R-PA) Institute with $1.2 The bill also provides billion and other NIH institutes with $4 billion. NIH advocates with the opportunity to rally In announcing the new bill during a Senate support in the Senate for significant increases for Appropriations Committee hearing on the the NIH next year. n NIH budget, Senator Specter called the five — Kevin M. Wilson

Congress Begins Work on Next NIH Budget

When it comes to the federal budget, including During a Senate Appropriations Committee the budget for the National Institutes of Health hearing on the FY2009 NIH budget, Senate (NIH), the Democrat-controlled House of Appropriations Committee Chair Senator Thad Representatives and Senate have decided, Cochran (R-MS) asked NIH Director Elias literally, to wait until next year. Zerhouni what an additional $1 billion would The House and Senate Appropriations mean for the NIH. Zerhouni told Cochran that Committees have begun working on the the additional money would allow him to start FY2009 budget for the NIH and the news, to provide protection for the next generation so far, is good. The Senate version of the bill of investigators. Addressing resource issues provides the NIH with a $1 billion increase, for connected with clinical trials, funding grant a total budget of about $30 billion. The House programs that encourage innovative research, bill provides the NIH with a slightly larger and integrating research across scientific increase, to $30.1 billion. disciplines were the other areas Zerhouni cited. Unfortunately, it may take some time In response to a question from Senator Tom before NIH-funded researchers see the effects Harkin, Zerhouni told the committee that it of an increased budget. Instead of passing was essential that future budgets for the NIH appropriations bills that will be vetoed by provide the scientific community with long- President Bush, the Democratic leaders in term budget predictability, a reasonable success Congress have decided to wait until the next rate of around 30%, and a sense of certainty President is inaugurated to complete the over time. n FY2009 budget process. — Kevin M. Wilson

AUGUST 2008 ASCB NEWSLETTER 9 NIH to Unveil New Disease Funding Database

Next spring, the National Institutes of the new system will not properly count Health (NIH) will unveil a new computer basic research grants with little or no clear system to catalogue how it spends taxpayers’ or direct disease-related implications. To money. The Research, Condition, and alleviate concerns about the new system— Disease Categorization (RCDC) system will and prevent potential misuse of the new provide Congress and the public with a more system by opponents of the NIH—NIH’s comprehensive idea of what areas of research are Office of Portfolio Analysis and Strategic funded by the NIH. Initiatives (OPASI) staff has been meeting The RCDC system will review each funded with congressional staff to explain the new grant and attribute funding to the appropriate system. OPASI has also created a website for disease categories that the research addresses. RCDC that includes an hour-long “webinar” The system currently has 360 possible disease explaining how the new system will work categories. when it becomes operational in February The basic research community has raised 2009. n concerns that the disease-based nature of — Kevin M. Wilson

CLS Congressional Biomedical Research Caucuses Held

Left to right: The Coalition for the Life Sciences (CLS) Congressional Biomedical Research Caucus speaker Susan Lindquist, Whitehead Institute for Biomedical Research/Massachusetts Institute of Technology, gave a briefing on “New Clues to Parkinson’s Disease from an Unlikely Source;” Lindquist and crowd at the Capitol Hill presentation.

Speaker Jacqueline Crawley of the National Institute of Mental Health/National Institutes of Health answered a In June, Paul Offit of Children’s Hospital of question posed by Congressional Biomedical Research Philadelphia presented a Congressional Biomedical Caucus Co-Chair Rep. Rush Holt (D-NJ) (front, second Research Caucus on “Are Childhood Vaccines Safe?” from right) after her briefing on “Testing Hypotheses about Autism.”

10 ASCB NEWSLETTER AUGUST 2008

eXcite Life!

Leica Microsystems introduces the Leica TCS SP5 X, the world's only white-light laser confocal microscope based on supercontinuum technology. The Leica TCS SP5 X is the only true spectral confocal system for the best imaging of live cell behavior using multiple dyes, simultaneously. The Leica TCS SP5 X confocal . . . • Illuminates dyes anywhere in the visible range with a single white-light laser. • Gives full spectral freedom in emission and excitation; ideal for multi-user environments. • Allows perfect excitation wavelength, tune-in and turn down laser power for increased cell life. • "Future-proofs" confocal investment by meeting fluorescence needs today and tomorrow. eXcite Life . . . email [email protected] today to schedule a FREE demonstration! Living up to Life

Effective undergraduate teaching in large courses sharing such resources in the public domain? is hard work. Even after years of teaching the Professional societies in the life sciences, with same topic, committed instructors still spend their extensive memberships and widely used hours preparing for each class, updating their Web portals, are well positioned to host open- material and improving their presentations. But access repositories of instructional materials. The a new ASCB initiative for sharing classroom ASCB several years ago established the Image resources may help lessen that burden. & Video Library (http://cellimages.ascb.org) to disseminate visual images for educational and Student-centered Teaching other purposes. The Society is currently in the For instructors trying to change the way they process of expanding this repository to other teach, the time demands of course preparation kinds of educational resources (see page 2). are especially great. Many instructors would like This could eventually include all those resources to move away from traditional mentioned above. lectures toward more student- Initially, the Society is centered classes that include building a collection of group work, problem solving, Within the “concept questions,” multiple- discussion, and other activities. choice questions that test This transition requires creating community of conceptual understanding new kinds of homework that life sciences and can be used with clickers pushes students to learn more in the classroom or in other of the material on their own instructors, there is ways. Submitted questions outside of class, as well as a largely untapped will be reviewed by a group of ASCB Education Committee new activities for meaningful reservoir of tested work during classes. Simply members for clarity and utility introducing new techniques, materials. before being accepted for such as use of the audience inclusion in the collection. response devices known as Questions will be grouped into clickers, is not enough. To be broad subject categories, and effective, clicker questions must be challenging, the collection will be searchable. Questions can testing conceptual understanding rather include images and will be provided as either than factual recall. They must also be clearly PowerPoint slides or text, with an accompanying formulated. Ideally, they should also be validated description to indicate the author(s); a title and by student interviews, with alternative answers other key words; the correct answer; the level that represent common student misconceptions. and subject of the course for which the question Creating such questions is not easy. was developed; and other useful information.

Tapping an Untapped Reservoir Please Share! We could make our teaching in general, and We are counting on ASCB members and others the transition to student-centered teaching in in the life sciences community to provide these particular, much less burdensome, by sharing questions. Please help make this collection a Professional more instructional resources. Within the useful resource by submitting questions you community of life sciences instructors, there is have found effective and urging your colleagues societies in the a largely untapped reservoir of tested materials. to do likewise. For more information on the life sciences… collection and how to submit, go to www.ascb. These include challenging clicker questions that are well positioned have been developed for courses throughout org/ivl/ and click on “Concept Questions: the typical biology curriculum. The content of Information and Submission Requirements.” to host open- some courses has been redefined, by replacing This is an effort that can benefit all of us who access repositories simple syllabi with specific learning goals. And teach undergraduates in the life sciences. n assessments of conceptual understanding—that —Bill Wood, for the ASCB Education Committee of instructional can be used as pre- and post-tests for measuring materials. student learning gains in specific subject areas— This article was excerpted from an editorial that are being developed. Wouldn’t it help all will appear in the Fall 2008 issue of CBE—Life instructors if there were mechanisms for easily Sciences Education (www.lifescied.org).

12 ASCB NEWSLETTER AUGUST 2008 Axioscope Bio Ad 8.5 x 11 6/16/08 10:22 AM Page 1

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Discover new dimensions of functionality. The completely modular system for all specific needs: from daily clinical routine to biomedical research. Listen to the Sound of Science. www.zeiss.com/functionality DEAR Labby

Dear Labby, You have helpfully answered queries about authorship issues before, but I have a new version. I work half-time as an electron microscopy technician and my other job is at the library of our university, where I am in charge of our Rare Books Collection. My lab PI was invited to review a book (a biography of a famous scientist) for a history of science journal and “declined.” (The reason for the quotes will become evident in a moment.) He asked me if I would like to do it, and I accepted. I read the book, liked it, but had some critical concerns, and, after many hours at my computer, I finalized a review. I then asked my PI about the address where I should send it. He stopped me in my tracks by saying “I’ll take care of that, as your co- author.” Co-author? Labby, he did nothing! The bottom line is that he feels he was the “catalyst” for this invitation and that gets him co- authorship. I know this is really different from the research article authorship quarrels you have dealt with before in your column, but I am so upset and don’t know what to do. —Reviewer without a Review

Dear Reviewer without a Review: Court decisions have established the doctrine that if a scholar produces something that only certain experts could have done, it is accorded certain legal status. This includes protection from inappropriate publication or other uses, copyright infringement, etc. Your PI clearly did not contribute to your review of this book. Moreover, this situation is profoundly different from a research paper in which the lab head can perceive, hold, or argue certain co- authorship rights. In writing this review you did not make use of an expensive fluorescence microscope purchased with his grant funds. Nor did you collaborate with him or his laboratory facilities in any way whatsoever. The province of reviews, including of books, is one that typically calls for sole authorship. While one can imagine certain cases when an interdisciplinary subject might require two collaborating reviewers, this genre of scholarship is most typically, and attractively, a solo act. After reading a review in The New York Review of Books, for example, one does not simply come away with a sense of the book; that sense is interwoven with the intellectual fabric of the reviewer. In Nature’s “News and Views” form, a related endeavor to book reviews, Miranda Robertson used to write with a level of erudition that often exceeded that of the articles she covered. Book reviewing and writing essays are “high table,” and not everyone would have the confidence to try it. You did, and that is significant and merits a sole byline. You should resist your PI’s claim to authorship. The integrity of the review is totally breached if it does not reflect the views of both (or all) authors. You indicate that your PI “declined.” I expect that means that he did not officially decline to the journal, but if he did so reply to the journal editor, that complicates his change of position even more. In that case, if he is unwilling to give up this demand for co-authorship, you should contact another suitable journal since, as mentioned above, the review is your scholarly work. Although book reviews are typically commissioned by journals (or written by staff), editors often are pleased to receive a high-quality uninvited review. If your PI didn’t officially decline, you should write the journal editor to indicate that your PI asked if you would like to write the review, you did so, and now are seeking to place it. No doubt my strong reply raises concerns about how your PI may respond, and what your ensuing work situation and security will be like. Given my own experience with this very same scenario when I was an insecure young scientist, I do feel strongly about what is the right thing to do. However, there is certainly a need for you to exercise judgment here. n —Labby

Direct your questions to [email protected]. Authors of questions chosen for publication may indicate whether or not they wish to be identified. Submissions may be edited for space and style.

14 ASCB NEWSLETTER AUGUST 2008 ASCB Profile

Elizabeth M. Wilson-Kubalek

On the day that it all became too much, electron crystallography for Nigel Unwin at Elizabeth (Liz) Wilson-Kubalek was signing off Stanford. DeRosier recalls, “For those of us who on the doctoral thesis of a Stanford graduate knew Liz well and encouraged her [to enroll student who’d done half of his thesis research in in graduate school], we often wondered if this her lab at the Scripps Research Institute in La really was the best thing for her to do. It was just Jolla, CA. Wilson-Kubalek remembers thinking, so much work. But, by golly, she did it.” “This is totally ridiculous. I can sign for a doctorate, but I don’t have one myself.” Ruining the Bell Curve In 2001, Wilson-Kubalek had a grant—a Mark Yeager is Wilson-Kubalek’s friend and competitive R01 from the National Institutes former colleague from the Unwin lab. Now of Health (NIH)—to pursue her novel idea he is the director of research in the Division of crystallizing proteins on lipid nanotubes to of Cardiovascular Diseases at the Scripps determine the 3D structures of the proteins by Clinic and a faculty member at the Scripps electron microscopy (EM) and image analysis. Research Institute. Yeager recalls running Elizabeth M. Wilson-Kubalek She had published more than into Wilson-Kubalek on the 30 papers. But Wilson-Kubalek Scripps campus, where she was didn’t have a Ph.D. She’d left teaching a basic seminar on her native Scotland at 18 with EM techniques for new grad a minimal qualification as a Wilson-Kubalek students and postdocs, while medical laboratory technician. she was enrolled in a required And yet she’d built a research remembers thinking, fundamentals course. “I career as an innovative electron “This is totally remember seeing her a couple microscopist who worked with ridiculous. I can of days before the exam. I knew many of the leading lights in that she’d enjoyed the course, protein structure, including sign for a doctorate, but she told me she was very Nigel Unwin, Jim Spudich, but I don’t have worried about her score. Well, Roger Kornberg, and Ron it turned out that her score was Milligan. Still without a degree, one myself.” so high that they had to pull there she was, certifying the her test out. Liz was ruining the work for someone else’s Ph.D. bell curve,” Yeager says with a In despair, Wilson- laugh. Kubalek went to see Sandy One would expect such Schmid, the chair of cell biology at Scripps. achievement from a woman with a third- Schmid was wonderfully supportive, Wilson- degree black belt in judo who used to compete Kubalek recalls. “Sandy said that she didn’t see internationally, says Yeager. “I think Liz is a why I shouldn’t be able to get into graduate wonderful model for all of us because of how school. And then I told her that I didn’t have a she’s managed to balance her life as a scientist, bachelor’s. Sandy said, ‘Hmm. That makes it a an athlete, a mother, and a mentor.” Wilson- little harder.’” But Schmid and Scripps dean Jeff Kubalek finally “walked” at the 2005 Scripps Kelly figured a way to pull together a Scripps graduate commencement. graduate school application for Wilson-Kubalek on the basis of her published work and outside The Road to Science recommendations. Wilson-Kubalek was born in Aberdeen, Wilson-Kubalek was admitted to the Kellogg Scotland, moving at 12 with her family to School of Science and Technology at Scripps in Edinburgh. Neither her parents nor her teachers 2002. For the next three years, Wilson-Kubalek thought much of her academic prospects. was a PI, a busy collaborator, and a full-time When she left high school at 16, she enrolled graduate student. It was a worrisome time for in a technical college program in Edinburgh to her friends and mentors, says David DeRosier, qualify as a medical laboratory technician. Two now emeritus at Brandeis. He first met Wilson- years later, she took the most direct way out Kubalek in the mid-1980s, when she was doing of Scotland, an airplane to Basel, Switzerland,

AUGUST 2008 ASCB NEWSLETTER 15 where she’d landed a job, long-distance, in a signed her up to do poster presentations, and private cytology lab. sent her in his stead to give seminar talks at She arrived with no other contacts and other institutions. For Wilson-Kubalek, giving with schoolgirl French but no awareness that a talk was not as hard as sitting through her people in Basel spoke German. Yet Wilson- introduction. “You know where they usually Kubalek recalls that flight as “one of the high introduce the speaker by saying that she did her points of my life. I never felt better than when bachelor’s here and her doctorate there? Well, I got on that airplane.” Until then, she says, they’d say, ‘Liz has a lot of experience,’” she “nobody ever thought I’d be doing anything.” recalls. In Basel, she began to change that expectation. Then in 1987, Unwin left Stanford to Wilson-Kubalek made friends and learned Swiss return to the UK and a post at the Medical German by joining a judo club. She picked Research Council in Cambridge. Wilson- up cytology in a flash—she had a knack for Kubalek’s personal situation made following recognizing pathological cells, she says—and was him impossible. To stay at Stanford, she soon put in charge of double-checking the work worked out a time-sharing deal between Jim of other technicians. But routine slide reading Spudich and Roger Kornberg. For Spudich, grew boring. Wilson-Kubalek decided that she she worked on the structure of myosin wanted to work in a research lab. At that point, II, a molecular motor in Dicyostelium. she’d never seen one. For Kornberg, she helped resolve the first Spotting a posting at the University of structures of Escherichia coli RNA polymerase Basel’s Biozentrum for an X-ray crystallography and yeast RNA polymerase by electron job for which she was totally unqualified, she crystallography. In 1992, she moved to Pat O. managed to talk her way into a tryout with Brown’s Howard Hughes Medical Institute– Hans Jansonius. He gave her a three-month trial supported lab, where she introduced the use and quickly realized that she was a fast learner. of nickel-chelated lipids for 2D crystallization In 1981, “Wilson, E.” made her first appearance of histidine-tagged proteins. She in the scientific literature as a middle author demonstrated the feasibility of this approach in a Journal of Cell Biology paper describing a by forming 2D crystals of HIV-1 reverse method of seeding protein crystals to grow out transcriptase on a nickel–lipid substrate. larger samples for X-ray crystallography. Besides her creativity, Wilson-Kubalek’s world-class bench skills have made her a By Degree valuable collaborator, explains Sidney “Wally” Jansonius became the first of a long line Whiteheart, now at the University of Kentucky. “This method of mentors who urged her to get a formal “If you look at all those papers she’s published with various groups, the center of all these with lipids and education. But a Swiss university degree would have required proficiency in three languages, papers is Liz’s ability to get the proteins to nickel derivatives and the UK offered her no educational prospects behave. That’s all to her credit.” has been quite either. Then former Jansonius lab members urged her to join them in San Francisco. A Decorated Nanotube successful, and Wilson-Kubalek fired off letters and took Although a successful collaborator, Wilson- almost everybody another plane ride into the unknown. Kubalek still found herself increasingly Her protein seeding expertise got her a frustrated at Stanford by her nondegree status. knows her from job in Sun-Hou Kim’s crystallography lab at In 1995, the situation came to a head with the that. She has quite the University of California, Berkeley. She breakup of her marriage and an offer from Ron an international loved Berkeley and American research, but Milligan, another Unwin lab veteran, to join his marriage and visa trouble forced a brief return lab at Scripps. It was in Milligan’s lab that she reputation. If you to Switzerland. It took the new couple two job came up with the idea to “decorate” nickel–lipid call up labs in hops to get back to California. Wilson-Kubalek nanotubes with histidine-tagged proteins. headed for the Stanford campus with Kim’s The technique made Wilson-Kubalek Europe or Japan, recommendation to seek out Nigel Unwin and well known in the community, according to they’ll know learn EM. DeRosier. “This method with lipids and nickel Wilson-Kubalek blossomed in the Unwin derivatives has been quite successful, and almost who Liz is.” lab, working on the nicotinic acetylcholine everybody knows her from that. She has quite receptor. She quickly mastered EM basics and, an international reputation. If you call up labs in at Unwin’s urging, learned new techniques such Europe or Japan, they’ll know who Liz is.” as cryo-EM and developed her own tweaks to That public profile was already growing in standard methods. Unwin did not treat her 1998 when Wilson-Kubalek was pushed into as a technician. He listed her on lab papers, giving the leadoff talk at a Tahoe Symposium

16 ASCB NEWSLETTER AUGUST 2008 when the featured speaker failed to appear. Kubalek was no longer the grant applicant “That was kind of nerve-racking,” she recalls. without a degree. But the NIH funding In the audience was Sue Schaffer, then deputy climate was already changing, and when the director for the National Institute of General application was denied, Wilson-Kubalek Medical Sciences at NIH. decided not to fight it. Today, Schaffer sought her out she is a senior staff scientist afterward, wanting to know in the Milligan lab, where what Wilson-Kubalek’s lab was You don’t have she enjoys collaborating with planning next. Wilson-Kubalek colleagues inside and outside repeated her old story—she to have a degree Scripps. Most recently she has didn’t have a lab because she to apply for an been working on kinetochore didn’t have a grant because she proteins with Arshad Desai of didn’t have a degree. Schaffer NIH extramural the University of California, interrupted her: You don’t have grant, said Sue San Diego (UCSD). to have a degree to apply for Schaffer. You need She lives in Cardiff-by- an NIH extramural grant, said the Sea, near La Jolla, where Schaffer. You need institutional institutional support she now shares custody of her support for lab space and an for lab space and 12-year-old daughter, Kyla appropriate title. And you need Wilson, with Kyla’s father, a good idea. an appropriate Gavin Meredith, a senior title. And you need scientist with Invitrogen. “Kyla A Green Light gets science from both sides,” a good idea. Wilson-Kubalek already had Wilson-Kubalek explains. the idea. Back at Scripps, “Right now, Kyla wants to be Bernie Giulia, who was then an environmentalist. She wants the chair of cell biology, gave to change the world.” Kyla, her a title—staff scientist—and who has just won a coveted a green light. “If Sue Schaffer place in a special summer says you can do this,” Giulia declared, “then science camp program at UCSD, may be on her I think you can do this.” Her first application way. “But Kyla’s not going to have problems like narrowly missed the funding cutoff, but the I did,” declares Wilson-Kubalek. “She’s had a revision sailed through. Ironically, by the time proper education right from the start.” n her R01 was up for renewal in 2005, Wilson- —John Fleischman

NAS Invites Nominations for Lounsbery Award

Intended to stimulate research and to encourage reciprocal scientific exchanges between the United States and France, the Lounsbery Award is given in alternate years by the National Academy of Sciences to a young American or French scientist in recognition of extraordinary scientific achievement in biology and medicine. The award is scheduled for presentation in 2009 to a young American scientist. In addition to the award of $50,000, a further sum is provided for the recipient to visit a laboratory or research institution in France. For more details about the award and nomination process, visit www.nasonline.org, and click on “Awards.” The deadline is September 15, 2008. n

AUGUST 2008 ASCB NEWSLETTER 17

WOMEN in Cell Biology The Science-Mentoring Paradox: Teaching and Learning to Experiment

Apprenticeship is the only way to learn and head and mentor. For junior members of impart a creative trade. Scientific research is a laboratory, the senior members can be such a trade, and it poses a challenge to mentor the most valuable role models. Similarly, and mentee alike: Neither can succeed without for junior faculty members, senior faculty the cooperation of the other. It is impossible should be considered a valuable source of to teach independence and the courage to be both positive and negative examples. It is original to a student who is not willing to take the mentees’ responsibility to seek advice risks. Thus, like the ancient from those whom they practice of apprenticeship or feel will be most helpful. good parenting, the mentor– And, conversely, it is mentee contract has aspects the responsibility of that can leave both parties the senior members of feeling it is a contract with the Figuring out how to labs and departments to devil. Here, I discuss the issues succeed at research respond thoughtfully and on both sides of the mentor– requires the same constructively to such mentee relationship with advances and requests for the hope of providing some skills as doing help. ground rules or at least food the project itself: A good scientific for thought. mentor does a disservice At some stage of training, experimentation to a student by giving too a graduate student or and observation. much supervision. If the postdoctoral fellow will rug-removal syndrome inevitably feel that the rug strikes at the postdoctoral has been rudely extracted stage, it means that the from underfoot. This graduate supervisor did often occurs after formal not fulfill an important coursework has stopped, and the remaining mentoring responsibility. However, while requirement is the nebulous prospect of doing science is all about taking risks, performing a successful research project. But calculated risk-taking behavior can be taught it can certainly occur at any time, even to the and learned. Like that of a good parent, the most independent student. Figuring out how mentor’s role is to impart survival skills, to succeed at research requires the same skills so striking the balance between coddling as doing the project itself: experimentation and throwing into the deep end is key. and observation. Active examples of strategy Too much emphasis on mentorship gives will be evident from observing more senior the impression that a program can be Like that of a good members of the laboratory, and the savvy prescribed and followed, which is completely parent, the mentor’s student should evaluate which styles and contradictory to the nature of the scientific approaches are most personally suitable (and enterprise. This being said, what are the role is to impart not suitable) from among many different most successful combinations of mentorship survival skills, so styles and approaches that are successful. and menteeship? striking the balance Leaving some of this responsibility to the student has the advantage of reinforcing Advice to the Mentee between coddling skills of observation. But it requires n Apply observational skills to the professional and throwing into routine lab meetings where research is as well as scientific side of your work. presented and critiqued, and establishing n Seek advice from colleagues at all stages the deep end is key. those is a key responsibility of the lab ahead of you.

AUGUST 2008 ASCB NEWSLETTER 19 n Be appreciative of advice and willing to example regardless of your gender: Don’t be accept it or at least consider it seriously. afraid to reach high in your pursuit of science! n Evaluate behavior of colleagues at all stages ahead of you. You all have learned reliance n Remember that there is no single prescribed On the sacred teachings of science, pathway for success; there is room for So I hope, through life, you never will decline individuality. In spite of philistine Defiance Advice to the Mentor To do what all good scientists do. n Create a lab or department environment Experiment. where junior members can interact with senior members. The apple on the top of the tree n Offer help but don’t go overboard on explicit Is never too high to achieve, instructions. So take an example from Eve, n Ask the mentee what he or she thinks the Experiment. next step should be, rather than prescribing Be curious, the next step. Though interfering friends may frown. n Be available and gracious about responding Get furious to specific requests for help or advice. At each attempt to hold you down. n In dispensing advice, consider the If this advice you always employ mentee’s individual needs and capabilities. The future can offer you infinite joy (Corollary: Different advice may be And merriment, appropriate for different individuals at the Experiment same career stage.) And you'll see. n —Frances M. Brodsky Advice to Both University of California, San Francisco Learn to approach career matters in the same way you approach lab work, by contemplating Acknowledgment the wisdom in this excerpt from Cole Porter’s The author thanks Inke Näthke for editorial song “Experiment” (1933), and follow Eve’s comments and suggestions.

20 ASCB NEWSLETTER AUGUST 2008 InCytes from MBC August, Vol. 19, No. 8

Atg8 Controls Phagophore Expansion during Autophagosome Formation Zhiping Xie, Usha Nair, and Daniel J. Klionsky Eukaryotic cells rely on autophagy to remove excess or damaged organelles and proteins. In this process, cytoplasmic materials are enveloped by a membrane sac, termed the phagophore, that matures into a double-membrane vesicle, the autophagosome. Autophagosomes eventually fuse with lysosomes, leading to degradation of the enclosed contents. Phagophore formation and maturation within the cytosol occurs at the phagophore assembly site (PAS). In this study, the authors demonstrate that Atg8, a lipid-conjugated ubiquitin-like protein, regulates the level of autophagy by controlling phagophore expansion and specifically limiting the size of autophagosomes, without affecting their number. Furthermore, by examining the trafficking of GFP-Atg8 in live cells, the authors show that each round of autophagosome formation involves a cycle of recruitment of Atg8 to the PAS and to the expanding phagophores, and its subsequent release prior to autophagosome maturation. The release of Atg8, which is mediated by lipid deconjugation, is essential for the completion of autophagosome formation.

Molecular Dissection of the Structural Machinery Underlying the Tissue-invasive Activity of MT1-MMP Xiao-Yan Li, Ichiro Ota, Ikuo Yana, Farideh Sabeh, and Stephen J. Weiss During events ranging from development and inflammation to metastasis, normal or neoplastic cell populations must traverse stromal tissues dominated by three-dimensional networks of collagen and fibrin. To cross these structural barriers migrating cells must mobilize proteolytic enzymes. Of the more than 500 proteinases encoded in the mammalian genome, only a small group of membrane-anchored metalloproteinases have been shown to confer cells with tissue-invasive potential. Membrane type 1 matrix metalloproteinase (MT1-MMP) is the prototypical member of this family of pro-invasive enzymes, but the structural domains critical for supporting three-dimensional invasion programs in vitro and in vivo have remained the subject of controversy. To date, MT1-MMP–dependent invasion has been thought to be linked to the enzyme’s unique patterns of exocytosis, surface oligomerization, internalization, and recycling. Unexpectedly, the authors now demonstrate that MT1-MMP can drive complex invasion patterns via a far simpler mode of action by functioning as a direct-acting, pericellular tunneling machine. These results provide novel insights into the mechanistic underpinnings of the three-dimensional invasion programs mobilized by migrating cells.

Intrinsic and CDK-dependent Control of Spindle Pole Body Duplication in Budding Yeast Laura A. Simmons Kovacs, Christine L. Nelson, and Steven B. Haase A fundamental question in cell biology is how cells faithfully duplicate their contents in preparation for cell division. Like DNA replication, centrosome duplication is tightly regulated so that it occurs only once each cell cycle. In metazoans, the structure of the duplicated centrosome precludes reduplication. In budding yeast, however, mitotic cyclin/cyclin dependent kinases (CDKs) inhibit reduplication of the yeast centrosome, the spindle pole body (SPB), although the mechanism is unclear. Here the authors show that mitotic cyclin/CDKs prevent SPB reduplication by blocking the premature initiation of early steps in the SPB duplication cycle, possibly by direct phosphorylation of SPB components. The authors also discovered evidence for an SPB-intrinsic block to SPB duplication, analogous to the mechanism identified in metazoans. This intrinsic block prevents SPB reduplication early in the cell cycle, before mitotic cyclins are expressed. Together, these coupled mechanisms ensure that the SPB is duplicated only once each cell cycle, and raise the question of whether CDK and intrinsic mechanisms collaborate to regulate centrosome duplication in metazoans.

The Role of Myosin II in Glioma Invasion of the Brain Christopher Beadle, Marcella C. Assanah, Pascale Monzo, Richard Vallee, Steven S. Rosenfeld, and Peter Canoll Gliomas are highly invasive brain tumors that are difficult to treat. Using novel in vivo model systems the authors have examined glioma migration in living brain tissue. They find that glioma cells have a remarkable ability to adapt the way that they move to the specific environment in which they find themselves. When invading brain, gliomas move in a distinct two-step process— extension of a long finger of cytoplasm, followed by saltatory forward movement of the nucleus and cell body. Myosin II is required to drive this second step. By contrast, when moving in a spatially unrestricted environment, glioma cells move much like fibroblasts and do not require myosin II. The authors also show that myosin II is specifically needed to squeeze the glioma cell body through pores smaller than its nuclear diameter. These findings suggest that gliomas need myosin II specifically to invade the densely packed microenvironment of the brain and that myosin II may be an effective target for the development of novel anti-invasive therapies for gliomas. n

AUGUST 2008 ASCB NEWSLETTER 21 Extra! Extra! Did You Know...? September 3 is the regular abstract submission deadline PIC Associates Spot (for poster consideration only) for this year’s ASCB Annual Meeting; the meeting will be held December 13–17 in San Hot Science News! Francisco, CA. n Sponsorship of abstracts is required. Breaking science news at the ASCB Annual Meeting is n All current members and member-applicants may sponsor sought by the ASCB Public Information Committee (PIC). their own abstract. To spot news, PIC needs extra-sharp minds and tireless n All regular, postdoctoral, and emeritus members may eyeballs to help Committee members screen the roughly sponsor another person’s abstract if they are not submitting 1,300 abstracts submitted for poster presentation at the one themselves. ASCB’s 48th Annual Meeting, December 13–17, 2008, in San Francisco. PIC members and those willing to volunteer Are there nonmembers in your lab who want to submit as PIC Associates will winnow those 1,300 abstracts down abstracts? Now is the time to encourage them to join ASCB. to a dozen “Novel & Newsworthy Top Picks.” These will Not only will they be able to sponsor their own abstract, be featured in Cell Biology 2008, the PIC’s press book for but they will be eligible for the discounted member-only science journalists covering the meeting and for the public. registration rate as well. For more information, go to www. Press book story selection will be done entirely online ascb.org and click on “Membership.” n in two separate screening rounds between August 15 and September 2, 2008. PIC Associates may also help during the Annual Meeting in the onsite ASCB Newsroom, at the Celldance Awards ceremony (Monday, December 15), and during CellSlam, the ASCB’s juried, stand-up science slam (Tuesday, December 16). Other PIC projects might also arise during the year. Dear Labby Wants You! Contact PIC Chair Rex Chisholm (r-chisholm@ northwestern.edu) or ASCB Science Writer John Who is Dear Labby? The American Society for Cell Biology’s Fleischman ([email protected]) for details.n (ASCB) popular advice columnist for scientists on professional issues. Dear Labby is also a monthly column in the ASCB Newsletter (see page 22). Send your career questions to [email protected] and, if your question is selected, Labby will provide you (and ASCB Newsletter readers) with great advice, threaded with wisdom NEW: Annual Meeting and good humor. All questioners may remain confidential.n Abstract Deadlines

The ASCB has instituted a new staggered submission process for the 2008 Annual Meeting. The deadlines are:

Regular Abstracts – August 7 (for minisymposium talkPASSED OR poster consideration) Life Scientist Regular Abstracts – September 3 (for poster consideration ONLY) Salary Survey Results Are you interested in U.S.-wide salary comparisons of life Late Abstracts – October 16 scientists? From February 15–June 2, 2008, The Scientist (for poster consideration ONLY) conducted a Web survey of salaries of 4,702 life scientists in the U.S. The results of the comprehensive analysis and a For more information or to submit an abstract: downloadable Data Explorer tool are available through links www.ascb.org/meetings on the ASCB homepage at www.ascb.org. n Questions? Contact [email protected].

22 ASCB NEWSLETTER AUGUST 2008 ASCB Seeks Staff Scientist

The staff scientist will assist with ASCB career development and science education programs, including regional meetings, Annual Meeting sessions, African workshops, grants writing and reporting, researching and following up on potential funding sources, and development of materials for diverse audiences using diverse venues and approaches (e.g., press releases, website postings, blogs, fact sheets, presentations, Facebook pages, Newsletter articles, e-journal clubs, advertisement text, letters).

Duties n Assist with scientific/educational aspects of Society’s initiatives, including the new ASCB website BioEDUCATE n Create effective outreach materials (releases, website postings, blogs, fact sheets, presentations, Facebook and Wikipedia pages, Newsletter articles, advertisements, letters) re: ASCB positions and bench to bedside scientific discoveries and disseminate to diverse audiences (ASCB members, Hill staff, media, the public, potential members) n Help assess and address the needs of, and publicize and market ASCB programs to, graduate students, postdocs, and early career scientists  Work with staff and members to implement special sessions/meetings focused on career development, funding, or other topics  Provide support to new subcommittee on graduate training/Graduate Council  Develop outreach materials n Help develop career development program for member graduate students, postdocs, and early career scientists that builds on current Minorities Affairs Committee, Women in Cell Biology Committee, and Subcommittee on Postdoctoral Training programs n Research funding opportunities n Write grant proposals and reports for Society programs, including child-care awards for ASCB Annual Meeting attendees and African workshops and awards n Manage small, regional, scientific meeting grant program: develop and process grant applications, coordinate with selection committee, provide support to local organizers n Provide support as needed for occasional caucuses and Hill Days

Requirements n Ph.D. in cell biology, developmental biology, molecular biology, or genetics n Excellent written and oral communication skills for diverse audiences n Track record of demonstrated commitment to deadlines and details n Ability to multitask n Knowledge of science education

Application Materials n Cover letter n CV n Two or three writing samples n Three references (names and contact information to be provided for follow up) n Salary requirements

Materials should be sent to Staff Scientist Search, ASCB, 8120 Woodmont Avenue, Suite 750, Bethesda, MD 20814-2762, USA, or emailed to [email protected] by September 19, 2008. Search is open until position is filled.

Logistics n The ASCB staff scientist will be based at the ASCB Office in Bethesda, Maryland, USA, and function within the administrative staff team. n He or she will report directly to the Executive Director. n Salary is negotiable. n

AUGUST 2008 ASCB NEWSLETTER 23 The ASCB 48th Annual Meeting December 13–17, 2008 Moscone Center, San Francisco, CA Robert D. Goldman, President n David L. Spector, Program Chair n Matthew D. Welch, Local Arrangements Chair Dynamic Nature of the Nucleoplasm Epigenetic Regulation Keynote Symposium Genevieve Almouzni, Centre National de la Recherche Scienti- Shiv Grewal, National Cancer Institute/NIH fique/Institut Curie Barbara J. Meyer, University of California, Berkeley/HHMI Saturday, December 13 Thoru Pederson, University of Massachusetts Medical School Genomic Instability and Cancer Cell Biology in the Genomic Era—6:00 pm Michael Rout, Rockefeller University John Sedat, University of California, San Francisco Thomas Ried, National Cancer Institute/NIH Francis S. Collins, National Human Genome Research Thea D. Tlsty, University of California, San Francisco Institute/NIH Impacts of Stem Cell Research on Cell Biology Helen Blau, Stanford University School of Medicine Imaging and Biosensors Symposia Fred H. Gage, The Salk Institute for Biological Studies Klaus Hahn, University of North Carolina at Chapel Hill Lawrence B. Goldstein, University of California, San Diego, Kai Johnsson, Ecole Polytechnique Fédérale de Lausanne Sunday, December 14 School of Medicine/HHMI Shinya Yamanaka, Kyoto University Impact of Protein Modifications on Cell Biology Cell Biology of the Senses—8:00 am Ron T. Hay, University of Dundee Craig Montell, Johns Hopkins University School of Medicine Deborah Morrison, National Cancer Institute–Frederick Ulrich Mueller, The Scripps Research Institute Minisymposia Leslie B. Vosshall, The Rockefeller University Information Technology for Cell Biology 3-D Electron Microscopy Steven J. Altschuler, University of Texas Southwestern Medical Chromatin Organization and Gene Jenny Hinshaw, National Institute of Diabetes and Digestive Center at Dallas Expression—10:30 am and Kidney Disease/NIH Walter Fontana, Harvard Medical School Susan M. Gasser, Friedrich Miescher Institute for Biomedical Gina Sosinsky, University of California, San Diego Research Interactions with the Cytoskeleton John T. Lis, Cornell University Actin and Actin-related Proteins Mary Beckerle, University of Utah/Huntsman Cancer Institute Tom Misteli, National Cancer Institute/NIH Alexander Bershadsky, Weizmann Institute of Science Holly V. Goodson, University of Notre Dame Louise Cramer, University College London Monday, December 15 Intermediate Filaments and Nuclear Lamins Development and Regeneration—8:00 am Actin-based Motors Yosef Gruenbaum, The Hebrew University of Jerusalem Brigid Hogan, Duke University Medical Center John A. Hammer, National Heart, Lung, and Blood Institute/ Jonathan Jones, Northwestern University Medical School Phillip Newmark, University of Illinois at Urbana-Champaign NIH Didier Stainier, University of California, San Francisco Matthew J. Tyska, Vanderbilt University Medical Center Lipid Dynamics Ken Jacobson, University of North Carolina at Chapel Hill Cell Migration and Metastasis—10:30 am Apoptosis Ivan Robert Nabi, University of British Columbia John Condeelis, Albert Einstein College of Medicine Sally Kornbluth, Duke University Medical Center Anna Huttenlocher, University of Wisconsin Kodi S. Ravichandran, University of Virginia Membrane Heterogeneity and Trafficking Joan Massagué, Memorial Sloan-Kettering/HHMI Greg Odorizzi, University of Colorado Cell Biology of the Immune System Jennifer Stow, University of Queensland Tuesday, December 16 Jason Cyster, University of California, San Francisco/HHMI Michael Dustin, New York University School of Medicine Microtubule-based Motors Nuclear Organization and Disease—8:00 am Kristen Verhey, University of Michigan Medical School The Rockefeller University Titia deLange, Cell Biology of the Synapse Isabelle Vernos, Centre for Genomic Regulation, Pompeu Gideon Dreyfuss, University of Pennsylvania School of Jose Esteban, Universidad Autónoma de Madrid Fabra University Medicine/HHMI Elly Nedivi, Massachusetts Institute of Technology Roland Foisner, Medical University Vienna Mitosis and Meiosis Cell Polarity and Epithelial Morphogenesis Alexey Khodjakov, Wadsworth Center Cytoskeletal Dynamics—10:30 am Elisabeth Knust, Max Planck Institute of Molecular Cell Christiane Wiese, University of Wisconsin–Madison Ueli Aebi, Biozentrum, University of Basel Biology and Genetics Claire Walczak, Indiana University Ian G. Macara, University of Virginia Non-Coding RNAs Toshio Yanagida, Osaka University Antonio J. Giraldez, Yale University Cell–Cell Communication Amy E. Pasquinelli, University of California, San Diego Wednesday, December 17 Timothy Springer, Harvard Medical School/Immune Disease Gene Regulation and Non-Coding RNAs—8:00 am Institute The Nuclear Envelope and Nuclear Pore Complex Gregory J. Hannon, Cold Spring Harbor Laboratory/HHMI Cornelis Wiejer, University of Dundee Martin Hetzer, The Salk Institute for Biological Studies Edith Heard, Institut Curie Iris Meier, Ohio State University Gisela Storz, National Institute of Child Health and Human Cellular Basis of Morphogenesis Development/NIH Lila Solnica-Krezel, Vanderbilt University Organelle Biogenesis and Turnover Deborah Yelon, Skirball Institute, New York University School Daniel Klionsky, University of Michigan Models for Stem Cell Biology—10:30 am of Medicine Jodi Nunnari, University of California, Davis Judith Kimble, University of Wisconsin-Madison Arnold Kriegstein, University of California, San Francisco Cellular Response to Infectious Agents Signaling from the Extracellular Matrix Haifan Lin, Yale University School of Medicine Thomas J. Hope, Northwestern University Feinberg School of Mina Bissell, Lawrence Berkeley National Laboratory Medicine Bernhard Wehrle-Haller, Centre Medical Universitaire F. Gisou van der Goot, Ecole Polytechnique Fédérale de University of Geneva, Switzerland Working Groups Lausanne Single Molecule Studies Cellular Basis for Motor Neuron Degeneration Centrosomes and Cilia Siegfried Musser, Texas A&M Health Science Center Susan Dutcher, Washington University School of Medicine James Spudich, Stanford University School of Medicine Don Cleveland, Ludwig Institute for Cancer Research, The Wellcome Trust/Cancer Research UK University of California, San Diego Jordan Raff, Gurdon Institute Stress Responses Kenneth Fischbeck, National Institute of Neurological Jason Brickner, Northwestern University Disorders and Stroke/NIH Randal Kaufman, University of Michigan Medical School/ Erika Holzbaur, University of Pennsylvania School of Endo- and Exocytosis HHMI Medicine Karin Reinisch, Yale University School of Medicine Livio Pellizzoni, Columbia University Medical Center Sanford M. Simon, The Rockefeller University

24 ASCB NEWSLETTER AUGUST 2008 AUGUST 2008 ASCB NEWSLETTER 25 GRANTS & OPPORTUNITIES

AAAAI ST*AR Program Grants. The American Academy of Allergy, Asthma, and Immunology is now inviting grant applications for its 2009 ST*AR Program, which will take place in Washington, DC, March 12–15, 2009. The program gives Ph.D. trainees an opportunity to network and to explore research and career opportunities. Applications are due by September 3, 2008. www.annualmeeting.aaaai.org.

HHMI Postdoctoral Fellowships. Howard Hughes Medical Institute will partner with the Jane Coffin Childs Memorial Fund, Helen Hay Whitney Foundation, Damon Runyon Cancer Research Foundation, and Life Sciences Research Foundation to fund 16 annual fellowships to help advance young scientists. www.hhmi.org/news/20070604postdoc.html.

Joint DMS/NIGMS Initiative to Support Research in Mathematical Biology. The National Institute of General Medical Sciences (NIGMS) and Division of Mathematical Sciences in the Directorate for Mathematical and Physical Sciences at the National Science Foundation (DMS) plan to support research in mathematics and statistics related to mathematical biology research. This competition is designed to encourage new collaborations at this interface, as well as to support existing ones. NIGMS and DMS anticipate making 15 to 20 awards totaling about $5 million, in fiscal year 2009. Each award will be between $100,000 and $400,000 (total costs) per year, for three to five years. www. nsf.gov/pubs/2006/nsf06607/nsf06607.pdf or http://grants.nih.gov/grants/guide/notice-files/NOT-GM-08-131.html.

NASA Research Announcement. Exploration Systems Mission Directorate, Advanced Capabilities Division, National Aeronautics and Space Administration Research Announcement solicits ground-based research in the fundamental space biology areas of microbial, plant, and cell biology. Electronic proposals are due by September 8, 2008. http://nspires.nasaprs.com.

National Centers for Biomedical Computing (R01). This funding opportunity is for projects from individual investigators or small groups to collaborate with the NIH Roadmap for Medical Research National Centers for Biomedical Computing (NCBCs). Collaborating projects are intended to engage researchers in building an excellent biomedical computing environment, using the computational tools and biological and behavioral application drivers of the funded NCBCs as foundation stones. Opening date: September 5, 2008. http://grants.nih.gov/grants/guide/pa-files/PAR-08-184.html.

NIAID Biodefense Fellowships. The National Institute of Allergy and Infectious Diseases is soliciting applications from biodefense training and development researchers of prevention, detection, diagnosis, and treatment of diseases caused by potential bioterrorism agents. Grants, fellowships, and career development awards. Multiple deadlines. www.niaid.nih.gov/biodefense/research/funding.htm.

NIGMS Grants. The National Institute of General Medical Sciences is accepting applications for funding research in which several interdependent projects offer significant advantages over support of these same projects as individual research. Standard NIH application dates apply. http://grants.nih.gov/grants/guide/pa-files/PA-07-030.html.

NIGMS National Centers for Systems Biology. The National Institute of General Medical Sciences (NIGMS) invites applications for National Centers for Systems Biology. The goal of the program is to promote institutional development of pioneering research, research training, and outreach programs focused on systems-level inquiries of biomedical questions within the NIGMS mission. grants.nih.gov/grants/guide/rfa-files/RFA-GM-09-009.html.

NIGMS RFA. The National Institute of General Medical Sciences is accepting applications for research on interventions that promote research careers. This funding opportunity will support research that tests explicitly identified assumptions and hypotheses that underlie existing or potential interventions intended to increase interest, motivation, and preparedness for careers in biomedical and behavioral research, especially interventions designed to increase the number of students from underrepresented groups entering such careers. Letters of intent are due September 30, 2008. Applications are due October 30, 2008. http://grants.nih.gov/grants/guide/rfa-files/RFA-GM-09-011.html.

NIH RFA. Applications are now being accepted for research on causal factors and interventions that promote and support the careers of women in biomedical and behavioral science and engineering. This funding opportunity will support research on: 1) causal factors explaining current patterns observed in the careers of women in biomedical and behavioral science and engineering and variation across different subgroups, and 2) efficacy of programs designed to support the careers of women in these disciplines. Causal factors include individual characteristics, family and economic circumstances, disciplinary culture or practices, and features of the broader social and cultural context. Letters of intent are due September 21, 2008. Applications are due October 22, 2008. http://grants.nih.gov/grants/guide/rfa-files/RFA-GM-09-012.html.

NIH Director’s Bridge Awards. This program will provide certain investigators with continued, but limited, funding to allow additional time to strengthen their revised R01 competing renewal applications. NIH components will nominate investigators to receive this support. http://grants.nih.gov/grants/guide/notice-files/NOT-OD-07-056.html.

26 ASCB NEWSLETTER AUGUST 2008 GRANTS & OPPORTUNITIES

NIH Roadmap. The NIH Roadmap has issued requests for applications in two new initiative areas: epigenomics (http:// nihroadmap.nih.gov/epigenomics/grants.asp) and the human microbiome project (http://nihroadmap.nih.gov/hmp/ grants.asp). The Roadmap has also reissued two program announcements related to high-throughput screening in the Molecular Libraries Probe Production Centers Network. http://nihroadmap.nih.gov/molecularlibraries/grants.asp.

NRSA Awards. The NIH Agency for Healthcare Research and Quality is accepting applications for the Ruth L. Kirschstein National Research Service Awards. The predoctoral fellowships promote diversity in health-related research. Application deadlines are May 1 and November 15 through 2009. http://grants1.nih.gov/grants/guide/pa-files/PA-06-481.html#SectionI.

NRSA Research Training Grant. The National Institute of General Medical Sciences will award MARC U-STAR National Research Service Act grants to minority-serving institutions that support undergraduate biomedical and behavioral research. Application deadline is May 25, 2009. http://grants.nih.gov/grants/guide/pa-files/PAR-07-337.html.

ORWH. The Office of Research on Women’s Health and other sponsoring centers/offices are accepting applications for funding opportunities that will advance new concepts in women’s health research and the study of sex/gender differences. Application deadlines are October 16, 2008, and October 16, 2009. http://grants.nih.gov/grants/guide/pa-files/PAS-07-381.html.

Research Supplements to Promote Diversity in Health-related Research. The supplements are intended to promote diversity in the biomedical, behavioral, clinical, and social sciences research workforce. Expiration: September 30, 2011. http://grants.nih.gov/grants/guide/pa-files/PA-08-190.html.

Research Supplements to Promote Re-Entry into Biomedical and Behavioral Research Careers. The supplements are intended to encourage individuals to re-enter research careers within the missions of all NIH program areas. This program will provide administrative supplements to existing NIH research grants to support full-time or part- time research by these individuals in a program geared to bring their existing research skills and knowledge up-to-date. Expiration: September 30, 2011. http://grants.nih.gov/grants/guide/pa-files/PA-08-191.html.

RISE (Research Internships in Science and Engineering). The German Academic Exchange Service (DAAD) offers scholarships to American and Canadian students to work on cutting-edge research projects at top research institutions (e.g., Max-Planck-Institutes) and universities in Germany. 2009 deadlines: Ph.D. students, November 30, 2008; undergraduates. January 31, 2009. www.daad.de/rise.

SCORE Awards. The National Institute of General Medical Sciences is accepting applications for its Support of A concise yet comprehensive resource Competitive Research (SCORE) developmental awards designed to increase faculty research competitiveness at minority-serving institutions. The program announcement, 2nd Edition as well as three other program announcements (PAR- Cell Biology 06-491, PAR-06-492, PAR-06-493), can be found at by Thomas D. Pollard, MD, http://grants1.nih.gov/grants/guide/pa-files/PAR-06-490. William C. Earnshaw, PhD, FRSE html#PartI. n with Jennifer Lippincott-Schwartz, PhD

What’s New in the 2nd Edition of Cell Biology? The latest version of this masterful introduction to the field now includes: # Spectacular new artwork by gifted artist Graham Johnson of the Scripps Research Institute, giving students realistic drawings that show the correct relative sizes and the shapes of all of the molecules for the first ‘life-like’ views of virtual cells at the molecular level. # New chapters and sections on the most dynamic areas of cell biology, including organelles and membrane traffic, RNA processing (including RNAi), and updates on stem cells and DNA Repair. # New easy access guide enables students to find figures featuring popular model organisms and specialized cells throughout the book. # New keystone chapter on the origin and evolution of life on earth.

# Improved organization and an accessible new design increase the focus on understanding concepts and mechanisms with a ‘bottom-up’ approach, allowing students to learn and retain general principles.

To request a desk copy: www.elsevierhealth.com or 1-800-222-9570

AUGUST 2008 ASCB NEWSLETTER 27 MEETINGS Calendar September 3–6. Florham Park, NJ September 28–October 2. Basel, Diseases Society of America 46th ARVO three-day course: Principles Switzerland Annual Meeting. and Concepts in Clinical Trials for Eye XXII International Complement www.icaacidsa2008.org. Researchers. www.arvo.org/ctes. Workshop, sponsored by the October 30–November 2. Asilomar, www.navbo.org/BSCVS. International Complement Society. CA www.akm.ch/ICW2008. ASCB September 11–14. Cape Cod, MA 2008 Biophysical Society Discussions Annual Meetings Biology of Signaling in the September 30. Portoroz, Slovenia on Calmodulin Modulation of Ion Cardiovascular System Workshop. ARVO one-day course: Designing Channels. www.biophysics.org/ 2008 Sponsored by the North American and Managing Clinical Trials in Eye discussions. San Francisco Vascular Biology Organization. Research. Held before the European November 30–December 3. The December 13–17 www.navbo.org/BSCVS. Association for Eye and Vision Netherlands Research Congress. www.arvo.org/ctes. 2009 September 12–16. Montréal, 6th European Congress of Biogerontology 2008, Ageing San Diego Québec, Canada October 6–7. Bethesda, MD ASBMR 30th Annual Meeting. Mitochondrial Biology in and Individual Life History. http:// December 5–9 www.asbmr.org/meeting/index.cfm. Cardiovascular Health and Diseases. biogerontology.lifespannetwork.nl. www.Mitochondrial2008.com. 2010 September 12–18. Heidelberg, December 7–10. San Diego, CA Philadelphia Germany October 7–10. Seoul, South Korea American Society for Matrix Biology. December 11–15 1st EMBO Conference on The 9th International Congress of Cell www.asmb.net/2008meeting. Centrosomes and Spindle Pole Biology, hosted by the Korean Society January 27–28, 2009. Bethesda, 2011 Bodies. www-db.embl.de/jss/ for Molecular and Cell Biology, on MD Denver EmblGroupsOrg/conf_87. behalf of the International Federation NIDDK-sponsored workshop on December 3–7 for Cell Biology. www.ifcbiol.org. September 18–21. Ames, IA Protein Misfolding and Misprocessing 17th Annual Growth Factor and October 17–22. Kos, Greece in Disease. www.3.niddk.nih.gov/fund/ 2012 Signal Transduction Symposium 8th International Conference of other/protein. San Francisco on Extracellular and Membrane Anticancer Research. www.ifcbiol.org. March 7–11, 2009. Charleston, SC December 15–19 Proteases in Cell Signaling. www. October 25–28. Washington, DC 2009 ASN Annual Meeting. http:// bb.iastate.edu/~gfst/homepg.html. 2013 48th Interscience Conference asneurochem.org/2009Meeting/ New Orleans on Antimicrobial Agents and ASN2009.htm. n December 14–18 Chemotherapy and the Infectious

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