BoothStop #1203 By More Imaging

With Molecular Devices’ complete turnkey solutions for high-content screening, expect more imaging from your screening, more easily and affordably than ever before.

More Imaging Systems ULTRA  New ImageXpress ™ confocal high-content screening system

INSTRUMENTS MICRO  ImageXpress ™ high-content screening system ASSAYS  ImageXpress® 5000A for live- and kinetic assays SOFTWARE INFORMATICS More Software DATA MANAGEMENT  MetaXpress™ for uniform image acquisition, processing and analysis  Application Modules for validated turnkey analysis of high- content images  AcuityXpress™ database-driven cellular informatics software for efficient yet powerful data mining and statistical capabilities MetaMorph®: the gold standard for research microscopy

More Assays  Transfluor® high-content assays for GPCR activation

Expect more. We’ll do our very best to exceed your expectations.

now part of MDS Analytical Technologies tel. +1-800-635-5577 | www.moleculardevices.com www.roche-applied-science.com

FuGENE® HD Transfection Reagent Measure the results of your transfection, not your transfection reagent.

Are you confident that the cellular effects you observe are the result of your 2000 transfected plasmid? Or are your results due to differential expression caused ■ 1741 affected by only this reagent by the transfection reagent you use? 1500 ■ Genes affected by Rely on FuGENE® HD Transfection Reagent to avoid the high levels of nonspecific, both reagents off-target effects that can be generated with other transfection reagents (Figure 1). 1000 1505 ■ Generate physiologically relevant data you can trust with a unique non-

500 liposomal formulation. 282 46 ■ Achieve greater cell survival 236 236 when transfecting with this low-cytotoxicity

Number of differentially expressed genes 0 reagent that is sterile filtered and free of animal-derived components. L2K FuGENE® HD Transfection Reagent Switch to FuGENE® HD Transfection Reagent to obtain meaningful results today! For more information and a database of successfully transfected cell lines, or to Figure 1. Minimize off-target effects by using FuGENE® HD Transfection Reagent. FuGENE® HD purchase, please visit www.powerful-transfection.com Transfection Reagent or a reagent from another supplier To place your order by phone, call 800 262 1640. (L2K) was used to transfect MCF-7 cells (ATCC® HTB-22™). Subsequent microarray expression profiling Please join us Monday, December 3, from 6:15 - 8:15 p.m. in Convention experiments demonstrated that L2K significantly altered Center Room 201 for our Technology Workshop. See presentations of real- the expression levels of six times more genes than world applications where FuGENE® HD Transfection Reagent has enabled FuGENE® HD Transfection Reagent. (View the complete research advancements. Visit us in Booth 705, December 2 - 4, to discuss article online in Biochemica (2006) 4 at www.roche- exciting new products and technologies for your research applications. applied-science.com/publications/biochemica.htm)

FuGENE is a registered trademark of Fugent, L.L.C., USA. Contact [email protected] for licensing and commercial applications. Roche Diagnostics The ATCC trademark and trade name and any and all ATCC catalog numbers are trademarks of the American Type Culture Collection. Roche Applied Science © 2007 Roche Diagnostics. All rights reserved. ASCB2007 Indianapolis, Indiana BoothStop #1203 By More MetaMorph

The metamorphosis continues! Introducing MetaMorph® 7 imaging software from Molecular Devices. Combining the most flexible and powerful tools for image acquisition, processing, and analysis, MetaMorph 7 offers a complete solution for even the most demanding live-cell imaging needs. New in MetaMorph 7:

4-D Viewer/3-D Measurements: Visualize multi-dimensional data sets and obtain 3-D measurements Application Modules: Accelerate image analysis with biology- specific modules for automated cell segmentation and quantitation Scan Slide: Automatically acquire, tile and stitch images of large samples MetaMorph® Live Replay: Capture real-time events, including a user-defined buffer interval prior to each event

Need to add hardware to the equation? Ask your local MetaMorph representative about our custom-integrated imaging workstations or visit www.metamorph.com for more information.

Expect more. We’ll do our very best to exceed your expectations.

now part of MDS Analytical Technologies tel. +1-800-635-5577 | www.moleculardevices.com INNOVATIVE DISCOVERY TOOLS FOR SIGNAL TRANSDUCTION RESEARCH The Highest Quality Antibodies for the Study of Translational Control ...from Technology

BiP (C50B12) Rabbit mAb #3177 Phospho-eIF2α (Ser51) (119A11) Rabbit mAb #3597

Confocal immunofluorescent analysis of Immunohistochemical analysis of paraffin-embedded human lung carcinoma (left) HeLa cells using #3177 (green). and breast carcinoma (right) using #3597. filaments have been labeled with Alexa Fluor ® 555 phalloidin (red). Blue pseudocolor = DRAQ5 ™ (fluorescent DNA dye). eIF4G (C45A4) Rabbit mAb #2469

Confocal immunofluorescent analysis of HeLa cells using #2469 (green). Actin filaments have been labeled with Fluor ® 555 phalloidin (red). Blue = DRAQ5 ™ fluorescent DNA dye.

4E-BP1 (53H11) Rabbit mAb #9644

Confocal immunofluorescent analysis of HeLa cells using #9644 (green), note the nuclear localization. Actin filaments have been labeled with Alexa Fluor ® 555 phalloidin (red). Blue = DRAQ5 ™ fluorescent DNA dye.

Alexa Fluor ® is a registered trademark of Molecular Probes, Inc. www.cellsignal.com

Orders (toll-free) 1-877-616-CELL (2355) [email protected] Fax ordering 1-978-867-2488 Technical support (toll-free) 1-877-678-TECH (8324) [email protected] Inquiries [email protected] BoothStop #1203 By More Modes

Molecular Devices is the #1 supplier of tunable microplate readers. Our two dual-monochromator multi-detection readers—the SpectraMax® M5e and FlexStation® 3 with integrated compound addition—give you superior results in all modes.

Widest spectrum of absorbance, fluorescence, and luminescence applications in microplates or cuvettes FP performance that is unparalleled by any tunable instrument TRF, HTRF®, IMAP® TR-FRET, and other TR-FRET assay capabilities Integrated plate stacker option for SpectraMax M5e Direct reagent transfer with 8- or 16-channel pipettor option on FlexStation 3 to increase kinetic assay throughput Complete SpectraTest™ hardware and SoftMax® Pro GxP software validation tools

Whether you’re screening at high throughput or developing assays in cuvettes or 6- to 384-well microplates, the SpectraMax M5e and FlexStation 3 can address a wider array of assays.

e Molecular Devices’ multi-detection readers: SpectraMax M5 Expect more. We’ll do our very best to exceed your expectations. (top) and FlexStation 3 with integrated fluid transfer (bottom).

now part of MDS Analytical Technologies tel. +1-800-635-5577 | www.moleculardevices.com More Assay Solutions

GPCR Discover Molecular Devices’ novel, high-performance assay solutions for the four major drug targets—GPCRs, compound ion channels, kinases, and membrane transporters. ion transporter channel More GPCRs: Assays, cells, and expression vectors for screening all classes of GPCRs; Gi, Go, Gs, and Gq. FA Transfluor® cell-based high-content imaging assay G- compound FA FLIPR® Calcium, Calcium 3, Calcium 4 assays cAMP Ca2+ CatchPoint® cAMP & cGMP assays LiveWare® G-protein cells and plasmids kinase compound nucleus More Ion Channel Assays: Homogeneous no-wash assays for direct and indirect ion flux activity. ® P P P FLIPR Membrane Potential assay protein protein protein FLIPR® Potassium Ion Channel assay More Kinases, Phosphatases, and Phosphodiesterases: Proprietary IMAP® platform; non-radioactive and non-antibody-based assays for screening kinases, phosphatases, and phosphodiesterases. IMAP® kinase, phosphatase, and FP/TR-FRET assays IMAP® PDE, FP, and TR-FRET assays More Membrane Transporters: Homogeneous fluorescent-based assays for measuring transporter uptake activity in end-point and real-time kinetic modes. Neurotransmitter Transporter Uptake Assay Fatty Acid Uptake Assay

now part of MDS Analytical Technologies tel. +1-800-635-5577 | www.moleculardevices.com © 2007 Thermo Fisher Scientific Inc. All rights reserved. rights Inc. All Scientific Thermo Fisher © 2007 subsidiaries. Inc. and its Scientific Thermo Fisher are the property of trademarks All

Same people. Same support. New possibilities.

If you work with , you’ve relied on Pierce reagents. For gene silencing, you’ve depended on Dharmacon innovations. In cell culture, HyClone is likely a good friend. For PCR, ABgene has helped you along the way. And for high content screening, you’ve trusted Cellomics and BioImage. Visit us at Booth #419 Now these top names in life science are sold under the Thermo Scientific brand. You’ll still find the same technical support and application expertise that you’ve come to expect. Only now, we can develop new ways to integrate technologies to accelerate and improve your results even further.

So yes, there’s a new brand name – Thermo Scientific. But you can keep your trusted relationships and high level of service as we unite to help you pursue new possibilities.

Moving science forward

Learn more at www.thermo.com/LSR.

Part of Thermo Fisher Scientific Confocal STED White Light Laser

TIRF Spinning Disk

Imaging Unlocked!

Innovation is the driving force at Leica Microsystems. Visit Leica at ASCB, booth #1102 to learn how Leica’s innovative new products for Life Science Research can unlock the imaging potential of your laboratory.

• STED STimulated Emission Depletion – The Abbe limit has been broken with the 90nm resolution of Leica’s confocal system. • White Light Laser – Maximize signal, minimize photobleachng with a single laser source. • TIRF Total Internal Reflection Fluorescence – Visualize events in detail with the easiest-to-use Multi-color system. • Spinning Disk – Image dynamic cellular processes, deblurred in real-time.

Visit Leica Microsystems at ASCB booth #1102 or call 800-248-0123 today for more information!

Leica Microsystems, Inc., 2345 Waukegan Road, Bannockburn, IL 60015 Tel. 847-405-0123, 800-248-0123, Fax 847-405-0164, In Canada call 800-205-3422 www.leica-microsystems.com ©2007 Leica Microsystems Inc., BNA#586

h mrcnSceyfrCl ilg 7hAna etn December1–5,2007 The AmericanSocietyforCellBiology47thAnnualMeeting SATURDAY SUNDAY MONDAY TUESDAY WEDNESDAY

7:00 am Exhibitor Showcases Exhibitor Showcases Exhibitor Showcases 7:30 am Registration Opens Registration Opens Registration Opens Registration Opens Career Center Opens Career Center Opens Career Center Opens Late Posters on Display Posters on Display Posters on Display Posters on Display 8:00 am Exhibitor Registration Opens Symposium I Symposium III Symposium V Symposium VII 8:30 am Registration Opens 9:00 am MAC Mentoring Symposium Exhibits Open Exhibits Open Exhibits Open Education Resources/MAC Booth Opens Education Resources/MAC Booth Opens Education Resources/MAC Booth Opens Education Resources/MAC Booth Opens 9:30 am Morning Refreshment Break Morning Refreshment Break Morning Refreshment Break Congress 101 9:45 am Alberts Award Presentation Education Initiative Forum Education Initiative Forum Education Initiative Forum 10:00 am SCOPT Meeting 10:30 am MAC Workshop Symposium II Symposium IV Symposium VI Symposium VIII 12:00 Noon MAC Awards Lunch WICB Career Discussion Lunch ASCB Business Meeting Late Poster Presentations K–12 Science Education Partnership Lunch Poster Presentations Poster Presentations Poster Presentations Postdoc Workshop 12:30 pm Workshop Offered by WICB High School Program Conversation with the NSF FCS Workshop Database Workshop 1:00 pm Special Interest Subgroups 1:30 pm Education Workshop Conversation with NIH 2:00 pm E.E. Just Lecture Congressional Liaison Committee Seminar NSF Grant Opportunities 2:30 pm Afternoon Refreshment Break Afternoon Refreshment Break Afternoon Refreshment Break WICB Network Reception 3:00 pm Education Resources/MAC Booth Opens Celldance Awards Registration Closes Minorities Affairs Poster Session/Reception 3:15 pm Minisymposia 25–32 3:30 pm Undergraduate Program 3:40 pm Minisymposia 1–8 Minisymposia 9–16 Minisymposia 17–24 4:00 pm Exhibits Close Exhibits Close Career Center/Posters/Exhibits Close 4:30 pm Undergraduate Poster Presentations 5:00 pm Registration Closes Registration Closes Registration Closes 5:30 pm Practice of Science

6:00 pm Keynote Symposium E.B. Wilson Medal Presentation & Address Tutorials CellSlam 2007 Late Posters Close Q Washington, DC Posters on Display Meeting Ends Career Center Opens 6:30 pm CBE—Life Sciences Education Reception WICB Evening Program & Awards Presentation 7:00 pm Registration Closes Public Service Award Presentation Keith R. Porter Lecture 7:30 pm Opening Night Reception Late Posters on Display After Keynote 9:00 pm Career Center/Posters Close Career Center/Posters Close Career Center/Posters Close The American Society for 47th Annual Meeting

December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org TABLE OF CONTENTS DAILY LISTING

SOCIETY OFFICERS/STAFF/COMMITTEES ...... 6 CBE-Life Sciences Education Reception ...... 48 Public Service Award Presentation ...... 48 GENERAL INFORMATION ...... 7 Exhibitor Showcases ...... 49 Onsite Information ...... 8 Poster Session 1 ...... 53 Hotels ...... 9 Safety and Security ...... 10 MONDAY Wireless Internet Access ...... 10 Program Summary ...... 82 Airports ...... 10 Symposium III ...... 83 Ground Transportation ...... 10 Congress 101 ...... 83 Rental Cars ...... 11 Education Initiative Forum ...... 84 Assistance for Disabled Travelers ...... 11 Subcommittee on Postdoctoral Training (SCOPT) Meeting ...... 84 International Travelers ...... 12 Symposium IV ...... 84 Safety Tips ...... 12 WICB Career Discussion Lunch ...... 85 Understanding Poster Sessions ...... 14 Congressional Liaison Committee Seminar ...... 85 ASCB Career Center ...... 14 NSF Grant Opportunities ...... 85 Annual Meeting Supporters ...... 15 Minisymposia 9–16 ...... 86 Corporate Members ...... 15 Practice of Science ...... 91 Education Committee Travel Awards ...... 16 Tutorials ...... 91 MAC Travel Awards ...... 17 WICB Evening Program and Awards Presentation ...... 92 Education Resources/MAC Booth ...... 19 Exhibitor Showcases ...... 93 Student/Postdoc Activities ...... 23 Tutorials A-H ...... 99 Author Disclosures ...... 24 Poster Session 2 ...... 101 Future ASCB Annual Meetings ...... 26 TUESDAY MAPS Program Summary ...... 130 Washington, DC/ASCB Hotels ...... 20 Symposium V ...... 131 Washington Convention Center ...... 21 Education Initiative Forum ...... 131 Exhibit Hall ...... 182 Symposium VI ...... 132 ASCB Business Meeting ...... 132 SATURDAY Conversation with NIH ...... 132 Program Summary ...... 28 Celldance Awards ...... 132 MAC Mentoring Symposium ...... 29 Minisymposia 17–24 ...... 133 Workshop Sponsored by WICB ...... 29 CellSlam 2007...... 138 Special Interest Subgroup Meetings ...... 30 Keith R. Porter Lecture ...... 138 Education Workshop ...... 34 Exhibitor Showcases ...... 139 MAC Poster Session/Reception ...... 34 Poster Session 3 ...... 143 Undergraduate Program ...... 35 Undergraduate Poster Presentations/Reception ...... 35 WEDNESDAY Keynote Symposium ...... 35 Program Summary ...... 172 Opening Night Reception ...... 35 Symposium VII ...... 173 Education Initiative Forum ...... 173 SUNDAY Symposium VIII ...... 174 Program Summary ...... 38 FCS Workshop ...... 174 Symposium I ...... 39 Database Workshop...... 174 Bruce Alberts Award Presentation ...... 39 Conversation with the NSF ...... 174 Symposium II ...... 40 Minisymposia 25–32 ...... 175 MAC Awards Lunch ...... 40 Late Poster Session ...... 180 Postdoc Workshop ...... 40 K–12 Science Education Partnership Lunch ...... 41 EXHIBIT INFORMATION High School Program ...... 41 Exhibit Hours ...... 181 E. E. Just Lecture...... 42 Exhibit Hall Floor Plan ...... 182 WICB Network Reception ...... 42 Directory of Exhibitors ...... 184 Minisymposia 1–8 ...... 43 Product Index ...... 209 E. B. Wilson Medal Presentation/Address ...... 48 AUTHOR INDEX ...... 221 2 The American Society for Cell Biology 47th Annual Meeting

December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org TABLE OF CONTENTS ALPHABETICAL LISTING

A Conversation with the NSF ...... 174 Activities of Special Interest to Students & Postdocs ...... 23 Corporate Members ...... 15 Airports ...... 10 Cytoskeletal Dynamics and Polarity (Minisymposium 3) ...... 44 Alberts, Bruce Award Presentation ...... 39 D Annual Meeting Supporters ...... 15 Database Workshop...... 174 and (Minisymposium 9) ...... 86 Drinking Policy ...... 9 Architecture of Signaling Systems (Symposium II) ...... 40 ASCB Business Meeting ...... 132 E ASCB Career Center ...... 14 Early Career Life Scientist Award ...... 18 ASCB Meeting Management/Business Offi ce ...... 7 Education Committee Travel Awards ...... 16 ASCB Newsroom ...... 7 Education Initiative Forums ASCB National Offi ce ...... 7 Integrating Quantitative Modeling into Cell Biology Assembling Complex Cytoskeletal Structures (Monday) ...... 84 (Minisymposium 25) ...... 175 Encouraging Students to Develop Scientifi c Thinking Skills: Assistance for Disabled Travelers ...... 11 New Methods for Assessing Performance (Tuesday) ...... 131 ATM Locations ...... 8 Yeast and Oxygen: Incorporating Functional Genomics Attendee Registration (Hours) ...... 7 Research into Three Integrated Undergraduate Laboratory Author Disclosures ...... 24 Classes (Wednesday) ...... 173 Education Workshop ...... 34 B Educational Resources/MAC Booth ...... 19 Badges/Replacement Policy ...... 8 Electricity ...... 12 Bernfi eld, Merton Memorial Award ...... 18 Epithelial Morphogenesis (Minisymposium 19) ...... 134 Biological Oscillators (Minisymposium 17) ...... 133 Evolution of Eukaryotic Endomembrane System British Society for Cell Biology Award ...... 18 (Minisymposium 20) ...... 135 Exhibit Hall Hours ...... 7,181 C Exhibit Hall Services ...... 7 Cameras ...... 8 Exhibit Management Offi ce ...... 7 Career Center ...... 14 Exhibitor Showcases Career Discussion Lunch Sponsored by WICB...... 85 Sunday ...... 49 CBE—Life Sciences Education Reception ...... 48 Monday ...... 93 Cell Biology and Disease (Minisymposium 18) ...... 133 Tuesday ...... 139 Cell Biology in Ten Years (Symposium VIII) ...... 174 Extracellular Matrix as a Memory Storage Device Cell Biology of Metazoan Development— (Minisymposium 28) ...... 176 Heinz Herrmann Symposium (Symposium III) ...... 83 Cell Biology of the Synapse (Minisymposium 26) ...... 175 F Cell Biology Working Group: Cell Biology of Alzheimer’s FCS Workshop ...... 174 Disease (Minisymposium 1B) ...... 43 First Aid/Nurse...... 7 Cell Biology Working Group: Nature of Cytoplasm Food/Beverages ...... 9 (Minisymposium 1A) ...... 43 Force and Form in Cell Biology (Symposium VI) ...... 132 Cell Cycle – MBC Paper of the Year Awardee-Ronald Lebofsky Future ASCB Annual Meetings ...... 26 (Minisymposium 2) ...... 43 /Motility (Minisymposium 10) ...... 86 G Celldance Awards ...... 132 Geography of Signaling (Symposium V) ...... 131 CellSlam 2007...... 138 Gilula, Norton B. Memorial Award ...... 18 Childcare ...... 8 Ground Transportation ...... 10 Children ...... 8 Chromatin Architecture and Remodeling (Minisymposium 27) 176 H Coat Check/Luggage Storage ...... 7 High School Program ...... 41 Congress 101 ...... 83 High-Tech Cell Biology (Minisymposium 29) ...... 177 Congressional Liaison Committee Seminar ...... 85 Conversation with NIH ...... 132

3 The American Society for Cell Biology 47th Annual Meeting

December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

Host-Pathogens Interactions and Innate Immunity Chromatin Architecture and Remodeling (Minisymposium 4) ...... 45 (Minisymposium 27) ...... 176 Hotel Map ...... 20 Cytoskeletal Dynamics and Polarity (Minisymposium 3) .....44 Hotels...... 9,20 Epithelial Morphogenesis (Minisymposium 19) ...... 134 Evolution of Eukaryotic Endomembrane System I (Minisymposium 20) ...... 135 Infant Changing Facilities ...... 9 Extracellular Matrix as a Memory Storage Device Intermediate Filaments and Nuclear Lamins (Minisymposium 28) ...... 176 (Minisymposium 5) ...... 45 High-Tech Cell Biology (Minisymposium 29) ...... 177 International Travelers ...... 12 Host-Pathogens Interactions and Innate Immunity Internet Kiosks ...... 9 (Minisymposium 4) ...... 45 Inquiry Cards ...... 9 Intermediate Filaments and Nuclear Lamins (Minisymposium 5) ...... 45 J Making ‘omics Useful to Cell Biologists Just, E. E. Lecture...... 42 (Minisymposium 21) ...... 135 Mechanics of Cytoskeletal Systems (Minisymposium 22) ..136 K Mechanisms of Epigenetic Regulation K–12 Science Education Partnership Lunch ...... 41 (Minisymposium 11) ...... 87 Keynote Symposium ...... 35 Mechanisms of Membrane Traffi cking (Minisymposium 12) ...... 87 L Mitosis and – Early Career Awardee-Abby Dernburg Laptop Link ...... 9 (Minisymposium 23) ...... 137 Lost and Found ...... 7 Molecular Motors: Alone and in Groups (Minisymposium 13) ...... 88 M Neuronal Cell Biology (Minisymposium 6) ...... 46 MAC Awards Lunch ...... 40 Nuclear Import and Export (Minisymposium 14) ...... 89 MAC Mentoring Symposium ...... 29 Nuclear Organization and Dynamics MAC Poster Session/Reception ...... 34 (Minisymposium 24) ...... 138 MAC Travel Awards ...... 17 Prokaryotic Cell Biology – Bernfi eld Awardee-Ethan Garner Making ‘omics Useful to Cell Biologists and WICB Junior Awardee-Christine Jacobs-Wagner (Minisymposium 21) ...... 135 (Minisymposium 15) ...... 89 Map—Hotels ...... 20 Protein Folding (Minisymposium 7) ...... 46 Maps—Convention Center ...... 21-22 Regulatory Roles of Lipid Microdomains MBC Paper of the Year ...... 18 (Minisymposium 30) ...... 178 Mechanics of Cytoskeletal Systems (Minisymposium 22) .....136 RNA Silencing Mechanisms (Minisymposium 31) ...... 178 Mechanisms of Epigenetic Regulation (Minisymposium 11) ..87 Signaling Through Cell Adhesion Proteins Mechanisms of Membrane Traffi cking (Minisymposium 12) ..87 (Minisymposium 8) ...... 47 Message Center ...... 8 Stem Cell Niches (Minisymposium 32) ...... 179 Metrorail and Metrosus ...... 11 X-ylation and Cell Signaling (Minisymposium 16) ...... 90 Membrane Dynamics (Symposium I) ...... 39 Mitosis and Meiosis – Early Career Awardee-Abby Dernburg Minisymposia (Minisymposium 23) ...... 137 Apoptosis and Organelles (Minisymposium 9) ...... 86 Molecular Motors: Alone and in Groups Assembling Complex Cytoskeletal Structures (Minisymposium 13) ...... 88 (Minisymposium 25) ...... 175 Biological Oscillators (Minisymposium 17) ...... 133 N Cell Biology and Disease (Minisymposium 18)...... 133 NSF Grant Opportunities in Biological Sciences and Cell Biology of the Synapse (Minisymposium 26) ...... 175 Educational Activities ...... 85 Cell Biology Working Group: Cell Biology of Alzheimer’s Neuronal Cell Biology (Minisymposium 6) ...... 46 Disease (Minisymposium 1B) ...... 43 Nuclear Import and Export (Minisymposium 14) ...... 89 Cell Biology Working Group: Nature of Cytoplasm Nuclear Organization and Dynamics (Minisymposium 24)..138 (Minisymposium 1A) ...... 43 Cell Cycle – MBC Paper of the Year Awardee-Ronald Lebofsky O (Minisymposium 2) ...... 43 Opening Night Reception ...... 10, 35 Cell Migration/Motility (Minisymposium 10) ...... 86

4 The American Society for Cell Biology 47th Annual Meeting

December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

P Subcommittee on Postdoctoral Training (SCOPT) Parking ...... 11 Meeting ...... 84 Photo Release ...... 10 Symposia Porter, Keith R. Lecture ...... 138 Architecture of Signaling Systems (Symposium II) ...... 40 Postdoc Workshop ...... 40 Cell Biology in Ten Years (Symposium VIII) ...... 174 Poster Display Hours ...... 8 Cell Biology of Metazoan Development— Poster Sessions Heinz Herrmann Symposium (Symposium III) ...... 83 Poster Session 1 ...... 53 Force and Form in Cell Biology (Symposium VI) ...... 132 Poster Session 2 ...... 101 Geography of Signaling (Symposium V) ...... 131 Poster Session 3 ...... 143 Membrane Dynamics (Symposium I) ...... 39 Late Poster Session ...... 180 Single Molecule Studies (Symposium VII) ...... 173 Practice of Science ...... 91 Unconventional Organelles (Symposium IV) ...... 84 Prokaryotic Cell Biology – Bernfi eld Awardee- Ethan Garner and WICB Junior Awardee- Christine Jacobs-Wagner T (Minisymposium 15) ...... 89 Taxi Serivce ...... 11 Protein Folding (Minisymposium 7) ...... 46 Tipping ...... 12 Public Service Award Presentation ...... 48 Tutorials (Monday) ...... 91,99 Public Telephones ...... 10 U R Unconventional Organelles (Symposium IV) ...... 84 Regulatory Roles of Lipid Microdomains Undergraduate Poster Presentations/Reception ...... 35 (Minisymposium 30) ...... 178 Undergraduate Program ...... 35 Rental Cars ...... 11 Understanding Poster Sessions ...... 14 RNA Silencing Mechanisms (Minisymposium 31) ...... 178 W S Waiver of Liability ...... 10 Safety and Security ...... 10 Washington, DC, Fast Facts ...... 13 Safety Tips ...... 12 Water Coolers ...... 10 Sales Tax ...... 12 WICB Evening Program & Awards Presentation ...... 92 Signaling Through Cell Adhesion Proteins WICB Junior Award ...... 18 (Minisymposium 8) ...... 47 WICB Network Reception ...... 42 Single Molecule Studies (Symposium VII) ...... 173 Wilson, E. B. Medal Presentation and Address ...... 48 Smoking Policy ...... 10 Wireless Internet Access ...... 10 Speaker Disclosure ...... 10 Workshop Offered by WICB ...... 29 Speaker Lounge ...... 8 Special Interest Subgroups ...... 30 X Stem Cell Niches (Minisymposium 32) ...... 179 X-ylation and Cell Signaling (Minisymposium 16) ...... 90 Student/Postdoc Activities ...... 23

5 The American Society for Cell Biology 47th Annual Meeting

December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org THE AMERICAN SOCIETY FOR CELL BIOLOGY

EXECUTIVE COMMITTEE President Bruce M. Alberts, University of California, San Francisco President-Elect Robert D. Goldman, Northwestern University School of Medicine Past President Mary C. Beckerle, University of Utah Secretary Jean E. Schwarzbauer, Princeton University Treasurer Gary E. Ward, University of Vermont

COUNCIL Kerry S. Bloom, University of North Carolina Timothy J. Mitchison, Harvard Medical School David R. Burgess, Boston College Sandra K. Masur, Mt. Sinai School of Medicine John S. Condeelis, Albert Einstein College of Medicine Barbara J. Meyer, University of California, Berkeley Susan K. Dutcher, Washington University School of Medicine Erin Keane O’Shea, Harvard University Scott D. Emr, Cornell University Anne J. Ridley, King’s College London Joan R. Goldberg, ex offi cio Susan Rae Wente, Medical Center Caroline M. Kane, University of California, Berkeley ASCB STAFF Trina Armstrong, Director of Meetings Katherine Hempel, Membership Manager Eric Baker, Journal Production Manager Cheryl Lehr, Executive Assistant/Offi ce Manager Howie Berman, Technical Program Manager W. Mark Leader, Director of Publications Charlie Mae Binder, Membership Assistant Lynn Marquis, National Coordinator, Joint Steering Committee for Public Policy Cindy Boeke, Assistant Director of Digital Resources Deborah McCall, Senior Manager, Minorities Affairs Thea Clarke, Education and Editorial Manager Tony McNeil, Staff Accountant David Driggers, Chief Information Offi cer Nancy Moulding, Public Policy/Production Coordinator David Ennist, Director of Digital Resources Edward Newman, Director of Marketing John Fleischman, Science Writer Elizabeth M. Rich, Production Manager Joan R. Goldberg, Executive Director Kevin Wilson, Director of Public Policy Alison Harris, Meeting Planner

COMMITTEES Constitution & Bylaws International Affairs Minorities Affairs Jodi Nunnari Richard Hynes Don Cleveland Mary C. Beckerle, Chair Anthony DePass, Chair Rob Phillips Dan Kiehart Bruce M. Alberts Lydia Villa-Komaroff, Vice Paul W. Sternberg Douglas Koshland Education Dacheng He Chair Aaron P. Turkewitz Sean Morrison Tim Stearns, Chair Cynthia G. Jensen Renato Aguilera Robert E. Palazzo Brian T. Greuel Satyajit Mayor David Burgess Public Information Daphne Preuss Triscia Hendrickson J. Richard McIntosh Richard Goldsby Rex L. Chisholm, Chair Janet M. Shaw Elisa M. Konieczko Mahasin A. Osman Veronica Lopez, Postdoc- Simon Atkinson Kenneth R. Miller Duanqing Pei toral Fellow Kerry S. Bloom Women in Cell Biology Maria L. Niswonger Mark Peifer Sandra A. Murray Lynne Cassimeris Ursula W. Goodenough, Lynne M. Quarmby, WICB David S. Roos Laura J. Robles Duane A. Compton Chair Liaison James A. Spudich Peter Satir Thomas T. Egelhoff Alexandra M. Ainsztein Holly V. Goodson Mark D. Rose Masatoshi Takeichi Maria Elena Zavala Elizabeth H. Blackburn Lynne Maquat Ernie Schiller Ronald Vale Anthony DePass, MAC Robert E. Palazzo Linda Silveira Christopher D. Watters Nominating Liaison Gregory Payne Samuel C. Silverstein Harvey F. Lodish, Chair Susan L. Forsburg Zena Werb Laura J. Robles, MAC Elisa M. Stone Gary G. Borisy Caroline M. Kane Liaison Kimberly D. Tanner Laurie E. Littlepage Local Arrangements Joanne Chory Michael Shelanski William B. Wood Elizabeth Marincola John Hammer, Chair Anthony P. Mahowald Kip Sluder Sandra K. Masur Robin L. Wright Mary Dasso Suzanne R. Pfeffer Meg Titus Inke Näthke Julie Donaldson Laura J. Robles Kathy Wilson Finance & Audit John Hanover Pamela A. Silver Suzanne R. Pfeffer Gary E. Ward, Chair Marjan Huizing Masatoshi Takeichi Public Policy Thomas D. Pollard Bruce M. Alberts Denise Montell Fiona M. Watt Thomas Pollard, Chair Lynne M. Quarmby Jane E. Aubin Jim Sellers Peter C. Agre Jennifer Roecklein-Canfi eld Robert D. Goldman Xufeng Wu Program Bruce M. Alberts, ex offi cio Sandra L. Schmid Gary Gorbsky R. Dyche Mullins, Chair Mary C. Beckerle Jean E. Schwarzbauer Naomi S. Morrissette Membership Bruce M. Alberts Paul Berg Vivian Siegel Frank A. Nicolai Jean E. Schwarzbauer, Cori Bargmann David Burgess Anne Spang Thoru Pederson Chair David Botstein Rex L. Chisholm Philip D. Stahl Fern Paula Finger Anthony P. Bretscher George Daley JoAnn Trejo Daniel C. Flynn Marileen Dogterom John D. Gearhart Zena Werb, ex offi cio Gary Ian Gallicano James E. Ferrell, Jr. Lawrence Goldstein Junying Yuan Dariusz Leszczynski Arash Komeili Ursula Goodenough Ivan R. Nabi Jennifer Lippincott-Schwartz Brigid Hogan Lucy E. O’Brien Andrew W. Murray Robert Horvitz 6 The American Society for Cell Biology 47th Annual Meeting

December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org GENERAL INFORMATION

ASCB NATIONAL OFFICE Room 102A CAREER CENTER HALL A (202) 249-4003 Saturday, December 1 6:00 pm–9:00 pm Saturday, December 1 8:30 am–7:00 pm Sunday, December 2 7:30 am–9:00 pm Sunday, December 2 7:30 am–5:00 pm Monday, December 3 7:30 am–9:00 pm Monday, December 3 7:30 am–5:00 pm Tuesday, December 4 7:30 am–4:00 pm Tuesday, December 4 7:30 am–5:00 pm Wednesday, December 5 7:30 am–3:00 pm COAT CHECK/LUGGAGE STORAGE West Registration $2.00 per item checked ASCB MEETING MANAGEMENT Room 102B Saturday, December 1 8:30 am–10:00 pm (202) 249-4001 Sunday, December 2 7:30 am–9:00 pm Saturday, December 1 7:30 am–8:00 pm Monday, December 3 7:30 am–9:00 pm Sunday, December 2 7:30 am–8:00 pm Tuesday, December 4 7:30 am–9:00 pm Monday, December 3 7:30 am–8:30 pm Wednesday, December 5 7:30 am–6:00 pm Tuesday, December 4 7:30 am–8:30 pm Wednesday, December 5 7:30 am–6:00 pm COMMERCIAL EXHIBIT HOURS Halls A/B Sunday, December 2 9:00 am–4:00 pm ASCB NEWSROOM Room 101 Monday, December 3 9:00 am–4:00 pm (202) 249-4008 Tuesday, December 4 9:00 am–4:00 pm Saturday, December 1 8:30 am–6:00 pm Sunday, December 2 7:30 am–6:00 pm EXHIBIT HALL POLICY Press Briefi ng 10:00 am–11:00 am For the safety of Exhibitors and meeting attendees, it is the policy of Monday, December 3 8:00 am–6:00 pm the ASCB that children under the age of 12 must be accompanied by Press Briefi ng 10:00 am–11:00 am an adult at all times. Children over the age of 12 must have a meeting Press Conference 3:30pm–4:30 pm badge. For the safety of small children, strollers are not permitted in Tuesday, December 4 8:00 am–6:00 pm the Exhibit Hall at any time. Press Briefi ng 10:00 am–11:00 am Wednesday, December 5 8:00 am–6:00 pm EXHIBIT MANAGEMENT OFFICE Halls A/B (202) 249-4010 ATTENDEE REGISTRATION East Registration Saturday, December 1 7:30 am–4:00 pm Saturday, December 1 8:30 am–7:00 pm Sunday, December 2 7:30 am–4:00 pm Sunday, December 2 7:30 am–5:00 pm Monday, December 3 7:30 am–4:00 pm Monday, December 3 7:30 am–5:00 pm Tuesday, December 4 7:30 am–4:00 pm Tuesday, December 4 7:30 am–5:00 pm Wednesday, December 5 7:30 am–3:00 pm FIRST AID/NURSE Hall A (near bottom of escalator on left) (202) 249-3108 ATTENDEE SERVICES East Registration Saturday, December 1 7:30 am–10:00 pm (202) 249-4011 Sunday, December 2 7:30 am–9:00 pm Saturday, December 1 8:30 am–7:00 pm Monday, December 3 7:30 am–9:00 pm Sunday, December 2 7:30 am–5:00 pm Tuesday, December 4 7:30 am–9:00 pm Monday, December 3 7:30 am–5:00 pm Wednesday, December 5 7:30 am–9:00 pm Tuesday, December 4 7:30 am–5:00 pm Wednesday, December 5 7:30 am–3:00 pm HOUSING/CITY INFORMATION East Registration (202) 249-4013 BUSINESS CENTER L Street Entrance Saturday, December 1 8:30 am–7:00 pm (Hours subject to change without notice.) (202) 249-3969 Sunday, December 2 7:30 am–5:00 pm Saturday, December 1 8:00 am–6:00 pm Monday, December 3 7:30 am–5:00 pm Sunday, December 2 8:00 am–6:00 pm Tuesday, December 4 7:30 am–5:00 pm Monday, December 3 8:00 am–6:00 pm Tuesday, December 4 8:00 am–6:00 pm LOST AND FOUND Room 102B Wednesday, December 5 8:00 am–6:00 pm (202) 249-4001

7 The American Society for Cell Biology 47th Annual Meeting

December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

Author Presentations: Sunday, December 2–Wednesday, December 5 What’s New at the Odd boards 12:00 Noon–1:30 pm ASCB Annual Meeting? Even boards 1:30 pm–3:00 pm SPEAKER LOUNGE Room 150A In Programs… Saturday, December 1 8:00 am–6:30 pm Q Fluorescence Correlation Spectroscopy Sunday, December 2 7:00 am–6:00 pm Workshop Monday, December 3 7:00 am–6:00 pm Tuesday, December 4 7:00 am–6:00 pm Q Useful Databases for Cell Biologists Workshop Wednesday, December 5 7:00 am–3:00 pm Q Two new Minisymposia featuring two Working Groups addressing a) The Nature of Cytoplasm RESTAURANT CONCIERGE and b) The Cell Biology of Alzheimer’s Disease A concierge, located in East Registration at the Restaurant/ City/Housing counter, will be available to make suggestions and Q Practice of Science on Peer Review reservations at local area restaurants. Q NSF Discussion on Science Education Saturday, December 1 8:30 am–7:00 pm Q Late abstracts (no longer printed) included Sunday, December 2–Tuesday, December 4 8:30 am–5:00 pm in the regular abstract CD and available in bins throughout the Washington Convention ONSITE INFORMATION ATM LOCATIONS Center and at specially marked kiosks for The Washington Convention Center ATMs are located on the L abstract reviewing Street North Lobby, L Street South Lobby, and the L Street Bridge. Q Special question and answer sessions with Symposia speakers for postdocs and students BADGES/REPLACEMENT POLICY Meeting badges must be worn at all times while in the Washington Convention Center. White badges with blue swirls indicate full On the Social Scene… meeting access to Exhibits and Sessions. Blue badges with blue swirls indicate meeting access to the Exhibit Hall only. Children over the Q Wizards basketball tickets available at a age of 12 must have a badge. discount There is a $15 charge for lost or misplaced badges. Photo Q WICB-sponsored daily Dinner Meet-Ups at identifi cation is required. To avoid these charges, please remember to 6:00 pm. (Meet colleagues and make dinner bring your meeting badge and materials with you to the meeting and keep them in a secure place. plans.) Q The Opening Night Reception at the CAMERAS Convention Center with the ASCB President Cameras and all other recording devices are prohibited in all session rooms, on the Exhibit fl oor, and in all poster and oral presentation and Council on Saturday evening immediately sessions. following the Keynote Symposium CHILDCARE MESSAGE CENTER East Registration Childcare services are available through Family Childcare, Inc. Message boards will be provided in the Washington Convention Individual or group sitters can be arranged to provide in-room hotel Center in East Registration. Messages may be left for registrants childcare. Reservations must be made at least 48 hours in advance to Saturday–Tuesday from 8:00 am–9:00 pm and Wednesday from ensure availability. For rates and further information, contact (202) 8:00 am–6:00 pm. 723-2051. As an additional source, the concierge at many of the participating POSTER SESSIONS HALLS A/B hotels may be able to provide you with a list of babysitting services. Poster Displays: The ASCB assumes no responsibility with respect to these Saturday, December 1 6:00 pm–9:00 pm services and accepts no liabilities relative to the services. At press Sunday, December 2 7:30 am–9:00 pm time the ASCB was investigating other childcare options. Monday, December 3 7:30 am–9:00 pm Tuesday, December 4 7:30 am–4:00 pm CHILDREN Children under the age of 12 are not permitted in the Exhibit Hall Late Posters Only: West Registration without an adult and must be under the supervision of an adult at Wednesday, December 5 7:30 am–6:00 pm all times. For the safety of small children, strollers are not permitted 8 The American Society for Cell Biology 47th Annual Meeting

December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org on the Exhibit fl oor. No children are allowed on the Exhibit fl oor HOTELS during set up and tear down. No exceptions. Comfort Inn Convention Center (202) 682-5300 Four Points by Sheraton (202) 289-7600 DRINKING POLICY Grand Hyatt Washington (202) 582-1234 The ASCB and the Washington Convention Center encourage responsible drinking for those drinking alcohol. Beer and wine, Hamilton Crowne Plaza Washington, DC (202) 682-0111 including non-alcoholic beer, wine, and soft drinks will be offered Hampton Inn (202) 842-2500 at the Opening Night Reception on Saturday, December 1, and Henley Park Hotel (202) 638-5200 throughout the meeting dates. Alcohol will not be served to anyone Hyatt Regency Capitol Hill (202) 737-1234 under the age of 21; purchasers should be prepared to show photo Marriott at Metro Center (202) 737-2200 identifi cation. Alcoholic beverages are allowed only in specifi c areas Morrison Clark Inn (202) 638-5200 and must not be taken out of these immediate areas. Red Roof Inn Downtown (202) 289-5959 FOOD/BEVERAGE SERVICES WASHINGTON CONVENTION CENTER Renaissance Washington, DC (202) 898-9000 Starbucks Grand Lobby Washington Plaza Hotel (202) 842-1300 Saturday–Wednesday 6:30 am–5:00 pm Located in the Grand Lobby by the 801 Mt. Vernon Place entrance, INFANT CHANGING FACILITIES Starbucks offers coffee and pastries. An infant changing room designated for those caring for infants is available at the Washington Convention Center in Show Offi ce B Go Gourmet on the Concourse Level outside Hall B. The room is equipped with Sunday–Wednesday 7:00 am–4:00 pm chairs and tables in private areas for changing diapers or nursing; Located in the L Street Concourse, Go Gourmet offers coffee, tea, electricity and a water cooler are also available. Parents and guardians muffi ns, bagels, whole fruit, yogurts, salads, soups, cold beverages, are responsible for providing infant care supplies. The infant changing and gourmet sandwiches. room is unsupervised, and the ASCB is not responsible for any accidents or injuries that may occur. The Supreme Court Saturday & Wednesday 11:00 am–3:00 pm INTERNET KIOSKS Located on upper level off the L Street Bridge. The Supreme Court is Two Internet kiosks that provide access for checking email and a retail food court offering creative and distinctive selections. surfi ng the Web are located in the L Street Lobby, South Building, Q Wolfgang Puck Express next to the ATM machines. Internet access at the kiosks is available at California-style pizza from a wood-burning stove; salads, soups, a nominal charge. The kiosks accept major credit cards. and sandwiches Q Quizno’s INQUIRY CARDS Toasted sandwiches and beverages Your badge doubles as a name badge and an exhibit inquiry card. Q Foggy Bottom Grill Attendees’ demographic information is encoded on the front of their Grilled cheese, hamburgers, grilled chicken, sandwiches, hot dogs, badge. veggie burgers, french fries, and assorted cold beverages. The ASCB Council encourages all Annual Meeting attendees to present their badge at each exhibit booth they visit. Exhibitors Executive Orders determine the success of their participation in the Annual Meeting Sunday—Tuesday 11:00 am–3:00 pm by the number of leads they accumulate from attendees visiting their Located on lower level of Hall A Concourse, the retail food court offers exhibit booths. We appreciate your cooperation; a successful exhibit creative and fun local choices: program helps defray the cost of running the Annual Meeting and Q Harry’s Steak & Cheese keeps registration fees to a minimum. Traditional Philadelphia steak & cheese with all the trimmings, along with freshly-squeezed cups of lemonade LAPTOP LINK Q Asian Cuisine Laptop Link is located in the L Street Lobby, South Building, outside of Traditional cuisine including General Tso’s chicken, lo mein, beef Meeting Room 103A. Laptop Link can accommodate a maximum of and broccoli, steamed vegetables, fried and white rice, spring rolls, and assorted beverages Q Salad Express/Panini Station Tossed salads along with freshly pressed panini (hot) sandwiches NOTICE TO ALL ATTENDEES made to your preference Q Wolfgang Puck (see above) Cameras and other recording devices are prohibited Q Foggy Bottom (see above) on the Exhibit fl oor and in all poster and oral

Hours of food services are subject to change. presentation sessions.

9 The American Society for Cell Biology 47th Annual Meeting

December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org eight individual users at one time. Laptop Link enables you to connect WIRELESS INTERNET ACCESS your own laptop and purchase Internet access at a nominal charge. The ASCB will provide free, wireless Internet access at the Washington Convention Center during the 2007 Annual Meeting. Access will NO SMOKING POLICY be available in limited common areas on Levels 1, 2, and 3. Meeting For the comfort and health of all attendees, smoking is not permitted attendees who wish to use the service should bring their own laptop in the Washington Convention Center. computer or PDA, with a wireless 802.11 b/g network card installed. Set the SSID (wireless network identifi er) to ASCB2007. Onsite PHOTO RELEASE technical support will not be provided. Please confi gure your wireless Photographs will be taken at the 2007 American Society for Cell connection before coming to the meeting. Remember to consider the Biology meeting. By registering for this meeting, you agree to allow security implications of using a wireless network and protect your the ASCB to use your photo in any ASCB publications and/or on any laptop accordingly. ASCB website.

OPENING NIGHT RECEPTION TRANSPORTATION All attendees are invited to attend the Opening Night Reception on Saturday, December 1, immediately following the Keynote AIRPORTS Symposium in the Washington Convention Center. Washington, DC, is serviced by three major airports.

PUBLIC TELEPHONES Dulles International Airport (IAD) The Washington Convention Center offers complimentary local www.metwashairports.com/Dulles (703) 572-2700 telephone calls (area codes 202, 301, and 703) from public telephones Located approximately 26 miles west of Washington, DC (35–45 located on the red walls. Long-distance calls may be made by using minutes) calling cards and operator assistance. Ronald Reagan Washington National Airport (DCA) SAFETY AND SECURITY www.metwashairports.com/national (703) 417-8000 The ASCB’s fi rst priority is the safety and security of attendees and Located approximately four miles south of Washington, DC (10–15 staff. The ASCB works closely with the Washington Convention minutes) Center and CES, Inc., as well as the hotels in the housing block and local authorities. Please remember to take off your meeting badge Baltimore/Washington International Thurgood Marshall Airport (BWI) when exiting the building. The ASCB is committed to making every www.bwiairport.com effort to ensure a safe and productive event for everyone. Please be Information and Paging: (800) 435-9294 aware of your surroundings at all times and note the closest emergency Baltimore Area: (410) 859-7111 exit in all facilities. For emergencies while in the Washington Washington Area: (301) 261-1000 Convention Center, contact a uniformed security offi cer or pick Located approximately 30 miles north of Washington, DC (40–50 up a white phone and dial 3333. For emergencies while in your minutes) hotel, please follow the hotel’s specifi c instructions. Union Station SPEAKER DISCLOSURE www.unionstationdc.com/transportation/asp The views expressed by speakers at the ASCB 47th Annual Meeting are Located approximately one mile from the Washington Convention solely the views of the speaker. They do not necessarily represent the Center (5–10 minutes) views of the ASCB. The ASCB makes no representation concerning and does not guarantee the source, originality, accuracy, completeness, or GROUND TRANSPORTATION reliability of any statement, information, data, fi nding, interpretation, SuperShuttle Washington advice, opinion, or view presented by any speaker or poster presenter. www.supershuttle.com (703) 416-7973 Economical, convenient service from Ronald Reagan Washington WATER COOLERS National, Dulles, and BWI airports to your hotel. See www.ascb. Filtered water coolers are located on the meeting room concourses. org/meetings for discount coupon. Call (800) BLUE-VAN for reservations 24 hours a day. WAIVER OF LIABILITY Each individual attending the ASCB Annual Meeting assumes all CIRCULATOR risks associated with his or her attendance and participation in on- www.dccirculator.com (202) 962-1423 and offsite activities. Each individual attendee agrees to indemnify Linking cultural, entertainment, and business destinations within the and hold harmless the ASCB and its governing bodies, offi cers, city’s central core, this transit system promotes ease of movement in directors, employees, and/or agents from all loss, damage, or liability Washington, DC. arising out of or related to his or her attendance at the ASCB 47th Annual Meeting.

10 The American Society for Cell Biology 47th Annual Meeting

December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

CIRCULATOR BUS SCHEDULE TAXI SERVICE Every 10 minutes Washington, DC, taxis operate on a zone, rather than meter system, Convention Center-SW Waterfront 7:00 am–9:00 pm daily and, by law, all rates must be posted in each cab. Rates are usually Georgetown-Union Station 7:00 am–9:00 pm daily $1.50 for each additional passenger. Cabs from Maryland and Additional Night Service: Virginia can take passengers from Washington, DC, to locations in Whitehaven-17th & I Streets their respective states, but not to different locations within the city. Sunday–Thursday 9:00 pm–12:00 Midnight For more information, call the DC Taxicab Commission or (202) Friday and Saturday 9:00 pm–2:00 am 645-6005. Smithsonian-National Gallery of Art Loop 10:00 am–4:00 pm daily ASSISTANCE FOR DISABLED TRAVELERS FARE: $1.00 Exact Change Cash, Metro Transfers, & Passes Accepted The Washington Convention Center has a very limited supply of Metro SmarTripTM Card wheelchairs onsite at the Information Desk. These wheelchairs are available on a fi rst-come, fi rst-served basis. Attendees must provide METRORAIL AND METROBUS a valid driver’s license and phone number to check out a wheelchair. Metrorail and Metrobus provide a safe and effi cient way of getting Wheelchairs must be returned to the Information Desk after use. around Washington, DC, and the metropolitan suburbs. Five rail lines Washington, DC, is a particularly accessible city for physically and an extensive bus system connect the District with the Maryland challenged visitors. Following are a few resources: and Virginia suburbs. Train lines are named for colors: Red, Yellow, Blue, Green, and Orange. Station entrances are marked by brown City Scooter Tours pylons capped with the letter “M,” and colored stripes indicate which ScootAround offers scooter and wheelchair rentals daily, weekly, lines are available. or longer. Call (888) 441-7575 for a free estimate. Or visit www. Route maps are posted at each station and inside each subway scootaround.com or www.cityscootertours.com. car. Metrorail opens at 5:30 am weekdays and 7:00 am on weekends. It closes at midnight Sunday–Thursday. On Friday and Saturday DisabilityGuide.org nights, it stays open until 3:00 am. Each train displays the name of its Detailed accessibility information for all Washington, DC, area farthest destination. Base subway fare is $1.35, with increases during attractions, restaurants, and bars. Call (301) 528-8664 for more rush hour and for longer trips. Rail fare cards can be purchased at information or to order a copy of the guide. vending machines located inside the stations. Fare cards are inserted into the turnstile gates to enter and exit subway platforms. The fare is automatically deducted each time you exit a station. To continue Metro System Guide your trip by Metrobus, obtain a transfer at your originating station A free guide providing information on Metro’s bus and rail system for before boarding the train. Buses travel to Georgetown and other areas the elderly and physically disabled. For copies call (202) 637-7000 or not serviced by the subway. visit www.wmata.com.

To obtain schedules for connecting Metrobus service, locations of Senior Citizens Counsel and Delivery Service Metro sales offi ces, and other public transportation information, call Custom-made group tour packages for senior citizens. Handicapped Washington Metropolitan Area Transit Authority at (202) 637-7000 equipment and wheelchair-accessible vehicles available by the day, or visit www.metroopendoors.com. week, and month; (202) 678-2800.

PARKING Smithsonian Access Brochure Parking is restricted during rush hours and some weekend hours A free guide that provides an overview of accessibility features, (check posted hours on street signs). If your vehicle is towed Friday parking entrances, interpreters, and special tours at the Smithsonian after 7:00 pm, or any time on weekends, you won’t be able to museums. Available in large print, Braille, audio cassette, and from retrieve it until Monday after 9:00 am. For details, contact the DC AOL (keyword: Smithsonian). For copies, call (202) 357-2700 Department of Motor Vehicles, 301 C Street, NW, Washington, DC (voice), or (202) 357-1729 (TTY); [email protected]. Also available online 20001; phone: (202) 727-5000. at www.si.edu/opa/accessibility. NOTE: Washington, DC, does not recognize out-of-state RENTAL CARS handicapped tags for free parking in front of meters. For information Members and meeting attendees are eligible for rental car discounts about parking, please call the DC Department of Motor Vehicles at through Avis and Hertz. Refer to the following codes when making (202) 727-5000 or visit dmv.washingtondc.gov. rental car reservations: Q Avis, (800) 230-4898. Code: T755300 Q Hertz, (800) 654-3131. Code: 1301817

11 The American Society for Cell Biology 47th Annual Meeting

December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org INTERNATIONAL TRAVELERS SAFETY TIPS

Washington is more than just the U.S. capital—it is also home to more Before and During Your Trip than 150 embassies, chancelleries, and diplomatic residences where Q Keep a list at home of the important credit cards and identifi cation colors, cultures, and languages mix like nowhere else. The following you plan to take with you. sections contain some tips and information to make international Q Remember to pack important documents, including driver’s license, visitors feel more at home. passport, credit cards, plane/bus tickets, and hotel confi rmation. Q Leave all nontravel related items such as local credit cards and New Passport Requirements irreplaceable photos, at home. Q As of October 26, 2005, all countries must issue passports with Q Take as little cash as possible. Carry traveler’s checks and credit digital photos or the required chip (e-passport) containing cards to cover expenses. biometric information about the individual. Q Accept no items from persons unknown to you to be carried on Q However, anyone issued a machine-readable passport prior to board an aircraft. October 26, 2005, will be “grandfathered in” and allowed to visit Q Never leave luggage unattended. the U.S. until the passport expires. Q International visitors who need a visa to travel to the U.S. must Upon Your Arrival in Washington, DC apply for one at an American embassy or consulate. For more Q Be careful what you say in the presence of strangers. Never reveal information, visit travel.state.gov. your room number or discuss plans for leaving the hotel in a crowded area where you can be overheard. Embassies Q Ask at the front desk or concierge desk about the neighborhood Many embassies offer guided tours with prior notifi cation. around the hotel so you know what, if any, streets to avoid. Arrangements can also be made by some embassies to host meeting Q Ask for a new room if the front desk clerk announces your room functions and private parties, offering an unmatched asset for any number. meeting planner. Embassy phone numbers are available by calling directory assistance at (202) 555-1212. A comprehensive listing of While in Washington, DC embassies is also available online at www.embassy.org. Q For your safety, in the event of an emergency, be sure to note the locations of all emergency exits in meeting rooms, exhibit halls, Multilingual Services and public areas while in the Washington Convention Center, as The White House, Kennedy Center, Library of Congress, and other well as in your hotel. attractions offer brochures in several languages. The Smithsonian Q Fill out the back side of your meeting name badge with emergency Institution provides multilingual information at the visitor’s center contact information and any pertinent medical information in the Castle building. Travelers Aid provides language interpretation (allergies, current prescription medications, etc.). services at the international arrival area at Dulles International Airport. Q Remember to remove your attendee badge when leaving the For details call (703) 572-2536 or visit www.travelersaid.org. convention center. Q Carry with you the name, address, and phone number of an Financial Services individual to contact in case of emergency. SunTrust Bank Q Avoid displaying large amounts of cash in public. 624 H St., NW Q Walk “smart” by researching the best way to get to your (Corner of 7th and H St.) destination. Washington, DC 20001 Q When traveling at night, choose sidewalks in lighted areas and (202) 737-8031 avoid walking alone. Q Lock windows and doors when leaving your hotel room. Q Use the door viewer to identify anyone requesting entry to your Sales Tax hotel room. Washington, DC’s sales tax is 5.75%. Total hotel tax, including sales Q Report any lost or stolen items to hotel management and to the tax, is 14.5%. Food and beverage tax is 10%. police. Q Don’t leave money, checks, credit cards, jewelry, or other valuables Tipping in your room. Take valuables with you or store them in the hotel Tipping is voluntary; gratuities are not automatically added to the safe deposit box. bill. Here are a few tipping guidelines: Waiters are usually given 15% Q Never put your room key down beside you on a restaurant table, of the bill. For outstanding service, tip 20%. Taxi drivers usually bar, or at poolside. receive 15% of the fare, and doormen, skycaps, and porters are usually tipped $1 per bag. Kids’ Safety Q When visiting local attractions, dress kids in bright clothing Electricity and designate a meeting site for lost family members. For small The electricity used in Washington, DC, is 110 volts. European children, write down their names and where they’re staying and appliances brought here will require a voltage transformer. put it in their pockets. 12 The American Society for Cell Biology 47th Annual Meeting

December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

Q Instruct kids not to open hotel room doors to people they don’t Q Park your vehicle in well-lit, well-traffi cked areas. know. Q Remove all personal items when parking your vehicle overnight. Q Make sure kids are familiar with hotel emergency escape routes. Q Create an emergency plan and meeting site. Parking & Curbside Regulations Q When parking your car at visitor attractions or around the city, Sightseeing note curbside regulations and park within marked stalls. If your Q Ask front desk staff at your hotel for directions to attractions you car is missing from where you parked it, call DMV Customer want to visit. Service at (202) 727-5000, to see if it has been towed. Q Be wary of strangers who seem overly anxious to help you. Never Q Parking Meters: Some meters only accept quarters and are enforced accompany a stranger anywhere. Monday-Saturday, 8:00 am–6:00 pm. Enforcement varies; please Q Visitors are major targets for pickpockets in many cities throughout carefully read signage posted on the meter. the world. Stay alert to what’s going on around you. Men should Q Tow Away Zone: Any location is potentially a tow away zone if carry their wallets in an inside pocket. you park illegally. Tow away zones are clearly marked and the Q Use protective gear when biking, skating, riding, and exploring regulations are strictly enforced. Washington, DC. Q Contesting a Citation: If you get a ticket, and you believe it is a Q Walk with another person when sightseeing or shopping, mistake, you may contest it in person, by telephone, or by mail particularly at night. within 30 days of issuance. For more information, please contact Q Avoid shortcuts and walkways between buildings during the day the DC Adjudication Services (contact information listed on and at night. ticket) or www.dmv.dc.gov.

Public Transit WASHINGTON, DC, FAST FACTS Q Have a current bus or Metro schedule. This information can Geography usually be obtained from the hotel concierge or front desk. Located midway along the eastern seaboard of the U.S., south of Q Know when the last scheduled pick-up at major attractions will Maryland, north of Virginia, and 233 miles south of New York City, occur. the Washington, DC, metropolitan area refers to the District of Q Always ask the taxi driver how much it costs to get where you want Columbia, plus seven Maryland counties (Anne Arundel, Calvert, to go. DC cabs charge by zones. They do not have meters. Charles, Frederick, Howard, Montgomery, and Prince George’s), Q Have exact fare for public transportation. fi ve Virginia counties (Arlington, Fairfax, Loudon, Prince William, Q Report bus and Metro concerns or complaints to (202) 637-1328 and Stafford), and fi ve Virginia cities (Alexandria, Fairfax City, Falls and taxi concerns or complaints to [email protected]. Please note the Church, Manassas, and Manassas Park). vehicle number. The District of Columbia is 67 square miles and divided into four Q When at a terminal for public transportation, never leave your quadrants: Northwest, Southwest, Northeast, and Southeast. The luggage unattended. U.S. Capitol building marks the center where the quadrants meet. Numbered streets run north-south. Lettered streets run east-west Vehicle Security (there are no J, X, Y, or Z streets), becoming two-syllable names, Q Do not advertise that you are a visitor. Place maps, travel brochures, then three-syllable names farther out from the center. Avenues named and valuables in the glove compartment or trunk before you get for U.S. states run diagonally, often meeting at traffi c circles and to your destination. Carry wallets, checkbooks, and purses with squares. you. Elevation: highest, 420 feet; lowest, sea level. Q Check the back seat before getting into your car. Population: The population is approximately 572,000 in DC and 5.4 Q Always lock your car. Don’t hide spare keys on or around your million in the entire metro area. vehicle. Climate: December monthly highs average 46˚F/8˚C; lows average Q Never leave your vehicle with the engine running. 32˚F/0˚C.

13 The American Society for Cell Biology 47th Annual Meeting

December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

Understanding Poster Sessions Session Number (1 is Sunday, 2 is Monday, 3 is Tuesday, and late posters on Wednesday.)

Poster Session 3 Session Location Halls A/B Session Title

Actin Dynamics and Assembly I Program Number (Entire abstract is searchable on the Abstracts CD using this number.)

Board Number (Odd boards are presented 12:00 Noon–1:30 pm; Even boards are presented 1:30 pm–3:00 pm.) Abstract Title 199 B152 Actin Polymerization Directs Elongation of Endothelial Cells: Role of the Zyxin-VASP Complex. F. Xu1,2, S. F. Noria1, L. B. Langille1; 1Toronto General Hospital, Toronto, ON, Canada, 2 Dept. of Pathobiology, University of Toronto, Toronto, ON, Canada

Author Affi liations (appear in same order as authors) Authors

ASCB Career Center Hall B Hours Saturday, December 1 6:00 pm–9:00 pm Sunday, December 2–Monday, December 3 7:30 am–9:00 pm Tuesday, December 4 7:30 am–4:00 pm

Participation Anyone attending the 47th Annual Meeting of the American Society for Cell Biology as a scientifi c registrant or as an exhibitor may use the Career Center at no additional cost.

Facilities Job posting and interview areas are available.

Job Posting Requirements Employers may post job descriptions, interview schedules, and contact information in a 32” x 44” space. Additionally, each employer’s space is supplied with two legal-size fi le jackets: a job-notice jacket to hold information for job seekers and a message jacket to hold messages from job seekers to employers. Job seekers may leave CVs, reprints of articles, requests for interviews, or other materials for recruiters.

Interviews 2’ x 4’ interview tables are provided on a fi rst-come, fi rst-served basis.

14 The American Society for Cell Biology 47th Annual Meeting

December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

The American Society for Cell Biology Gratefully Acknowledges the Following Annual Meeting Supporters Bristol-Myers Squibb Research and Development National Institute of Environmental Health Sciences The Burroughs Wellcome Fund National Institute of General Cadmus Communications Medical Science Carl Zeiss Microimaging, Inc. National Library of Medicine Chroma Technology Corporation National Science Foundation , Inc. Nature Publishing Group Encyclopedia of Life Sciences NIH Offi ce of Research on Women’s Health Garland Science, Taylor & Francis Group Olympus America, Inc. Genentech Optical Imaging Association Hoffmann-La Roche The Rockefeller University Press/ JEOL USA, Inc. The Journal of Cell Biology Merck Research Laboratories Worthington Biochemical Corporation National Institute of Child Health & Human Development

Corporate Members The ASCB is grateful to its Corporate Members for 2007: Gold BD Biosciences Silver AbD-Serotec, A Division of Morphosys Biogen/Idec Carl Zeiss Microimaging, Inc. Chroma Technology Corporation Genovac GmbH Leica Microsystems Millipore Corporation Roche Applied Science Bronze Cell Sciences Corning Incorporated Guava Technologies, Inc. Hoffman LaRoche, Inc. JDSU Nikon Instruments, Inc. Olympus America, Inc. Veeco Instruments

15 The American Society for Cell Biology 47th Annual Meeting

December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org 2007 EDUCATION COMMITTEE TRAVEL AWARDS ASCB/Worthington Predoctoral Awardees Daniel Paranhos Zitterbart, University of Erlangen-Nuremberg The ASCB Education Committee has selected the following top-ranked students to Srikanth Polusani, University of Texas Health Science Center, San Antonio receive travel awards, supported by the Worthington Biochemical Corporation, to the Tamara Potapova, University of Oklahoma Health Sciences Center ASCB 47th Annual Meeting in Washington, DC: Amit Prasad, Sanjay Gandhi Post Graduate Institute of Medical Sciences Ilene Boucher, Boston University School of Medicine Kristen Rahn, Pennsylvania State University Lucy Cassar, Monash University Sherri Rankin, Memorial University of Newfoundland Josefi na Duran, Instituto Nacional de Salud Publica Rita Reis, Institute for Molecular and Cell Biology Marko Jovic, University of Nebraska Medical Center Ana P. Rodrigues-Martins, Instituto Gulbenkian de Ciência Jennifer Levy, University of Pennsylvania Komal Sane, Wayne State University Amity Manning,Dartmouth Medical School Ekta Seth Chhabra, Dartmouth College Zhe Sha, Baylor College of Medicine Jonathan Shaffer, University of Pittsburgh ASCB Predoctoral Student Travel Awardees Alok Shah, University of Iowa The ASCB Education Committee has also selected the following predoctoral students Robert Simone, University of Pennsylvania to receive travel awards, supported by the National Institute of Environmental Health Jitendra Singh, Jawaharlal Nehru University Sciences: Michael Skalski, University of Guelph Catherine Au, McGill University Shrivani Sriskanthadevan, University of Toronto Roslyn Bauer, University of Colorado Health Sciences Center Madhulika Srivastava, University of Allahabad Paula Bernal, University of Pittsburgh Ning Sun, Iowa State University Guillaume Castillon, Universite Sciences II Sarah Tague, University of Kansas Medical Center Binyue Chang, University of South Carolina School of Medicine Michael Van Kanegan, University of Iowa Buxin Chen, Georgia Institute of Technology Phillip Vanlandingham, University of Oklahoma Health Sciences Center Justin Chun, University of Alberta Lavanya Vasudevan, Cornell University Gulsen Colakoglu, The Ohio State University Divya Verghese, National Institute of Immunology Tara Deans, Boston University Preethi Vijayaraj, Institute for Physiological Chemistry Luqin Deng, University of Alabama at Birmingham Fengsong Wang, Cellular Dynamics Renee Donahue, Pennsylvania State College of Medicine Kai Wang, University of Alabama at Birmingham Ryan D’Souza, National Institute for Research in Reproductive Health Yang Wang, University of Hong Kong Wassim El-Jouni, University of Arkansas Medical School Elissa Wai Pung Wong, Population Council Margo Frey, University of Massachusetts Medical School Jia Yin, Wayne State University Fei Geng, McMaster University Kai Yuan, Morehouse School of Medicine Gaurav Goyal, National Centre for Biological Sciences Kathryn Harris, University of Toronto ASCB Postdoctoral Travel Awardees Mariana Hernandez, Universidad de San Martin The ASCB Education Committee has selected the following postdoctoral fellows to Liam Holt, University of California, San Francisco receive travel awards, supported by the National Institute of Environmental Health María Iribarne, Facultad de Ciencias Biomédicas Sciences: Christina Kaiser, University of Pennsylvania Joshua Bembenek, University of Wisconsin–Madison Sarah Kehoe, University of Florida Bhushan Desai, Northwestern University Rishikesh Kulkarni, Cincinnati Childrens Hospital Research Foundation Shilpa Gandre, University of California, Los Angeles, David Geffen School of Kraig Kumfer, University of Wisconsin Medicine Jennifer Larson, Louisiana State University Health Sciences Center Chunlei Gao, State University of New York–Upstate Medical University Samuel Lasse, University of California, San Diego Zhen Guo, Hefei National Laboratory James Lee, Emory University Kevin Hamill, Northwestern University Kuo-Chang Lee, University of Queensland Isabelle Jourdain, Massey University Stephanie Levi, University of Chicago Sujeong Kim, Ajou University School of Medicine Kuan-Yin Lin, Baylor College of Medicine Daniel Marston, University of North Carolina at Chapel Hill Shen Lin, King’s College London Lawrence Rajendran, Max Planck Institute of Molecular Cell Biology Hui-Lin Liu, The Ohio State University Juli Unternaehrer, Children’s Hospital Boston Shyamali Mandal, University of Nebraska Medical Center Sarah Wignall, Stanford University Irina Matos, Institute for Molecular and Cell Biology Michele Wozniak, University of Pennsylvania Rima Mendonsa, University of California, Davis Sawako Yamashiro, Emory University Angela Messmer, University of Toledo Suzanne Young, Indiana University School of Medicine Christoph Metzendorf, Uppsala University Aziz Mithani, University of Oxford Shota Mizunoe, Kumamoto University Min Mo, Otago University Mori Mohseni, University of Illinois–Chicago Subhanjan Mondal, University of Cologne Debarati Mukherjee, Purdue University Rajarajeswari Muthukrishnan, Indiana University School of Medicine Noushin Nabavi, University of Toronto Jun Namkung, Wonju College of Medicine, Yonsei University Tania Nayak, The Ohio State University John Opoku-Ansah, University of Hawaii 16 The American Society for Cell Biology 47th Annual Meeting

December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

Connie Cheng, Pomona College Charley Gruber, Texas A&M University ASCB Undergraduate Travel Awardees Matthew Herring, University of Colorado at Colorado Springs The ASCB Education Committee has selected the following undergraduate students Lokesh Kukreja, Lake Forest College to receive travel awards, supported by Chroma Technology Corporation: Jason Lei, The College of New Jersey Stephen Beishir, University of Minnesota Stephenia Omeh, University of Nigeria, Nsukka Dominika Bienkowska, University of Wisconsin–Madison Michael Slisz, Monmouth University Lisa Bond, National Institutes of Health Mithaq Vahedi, Lake Forest College

2007 MINORITIES AFFAIRS COMMITTEE TRAVEL AWARDS The ASCB Minorities Affairs Committee has selected the following students and scientists to receive travel awards, which are funded through an NIH NIGMS MARC grant and a generous contribution from The Burroughs Wellcome Fund: Sujeil Acevedo Mendez, University of Puerto Rico Carlene Moore, University of Alabama Joy Agee, Spelman College Vivian Navas, University of Puerto Rico, Mayaguez Ruben Aguilar, Purdue University Thomas Onorato, LaGuardia Community College Cindy Arrigo, New Jersey City University Wilda Orisme, University of Florida Petrina Barnett, Spelman College Karen Osorio, Cornell University Jose A. Barrera, University of Texas Southwestern Medical Center KiTani Parker-Johnson, Xavier University of Louisiana Maria Camargo, Chicago State University Emmanuel Peprah, Emory University Carmelo Carmona, University of Puerto Rico, School of Medicine Omar Quintero, Mount Holyoke College Franklin Carrero-Martinez, University of Puerto Rico, Mayaguez Renee Reams, Florida A&M University Linette Castillo-Pichardo, University of Puerto Rico, Medical Sciences E. Gloria Regisford, Prairie View A&M University Katheryn Chavez, Cornell University Juan F. Reyes, Northwestern University Shahnjayla Connors, University of Florida Alexis Rodriguez, Albert Einstein College of Medicine Gloria M. Conover, University of Arizona Francisco J. Sanchez-Rivera, University of Puerto Rico at Mayaguez Charisa Cottonham, University of Massachusetts Medical School Teresa Shakespeare, State University of New York at Stony Brook Kiyya Davis, Medgar Evers College Mary-Pat Stein, California State University, Northridge Charles des Bordes, Medgar Evers College Tesheka Stevenson, Emory University Sarah Gierke, University of California, San Francisco John Tenayuca, California State University, Bernardino Alain Goldman, LaGuardia Community College Danielle Thompson, University of Massachusetts Pedros Granados, LaGuardia Community College Jeff Thompson, California State University, Bernardino Lalisse Guillen, University of Puerto Rico at Mayaguez Cristy Tower, University of Alabama at Birmingham Latanya Hammonds-Odie, Spelman College Stephanie Valtierra, Lake Forest College Kimberly Hobbs, University of Alabama in Huntsville Oluseyi Vanderpuye, Albany State University Damon Jacobs, University of North Carolina at Chapel Hill Armando Varela, University of Texas at El Paso Shy’Ann Jie, Medgar Evans College Micaela Vargas, University of Texas at San Antonio Inneke Johnson, North Carolina Central University Nathalie Velarde, New York University Steve Keiko, Morehouse College Luis Vidali, University of Massachusetts Michelle Lozada, University of Puerto Rico at Mayaguez Tarsha Ward, Morehouse School of Medicine Lymarie Maldonado-Baez, Johns Hopkins University Velinda Woriax, University of North Carolina, Pembroke Robert McClintock, Prairie View A&M University Carmen Young, Spelman College Eva McGhee, University of California, San Francisco

And, Don’t Forget to Visit the ...

ASCB Career Center (Hall B) Saturday, December 1 6:00 pm–9:00 pm Sunday, December 2 7:30 am–9:00 pm Monday, December 3 7:30 am–9:00 pm Tuesday, December 4 7:30 am–4:00 pm

ASCB Exhibit Hall (Halls A/B) Sunday, December 2 9:00 am–4:00 pm Monday, December 3 9:00 am–4:00 pm Tuesday, December 4 9:00 am–4:00 pm

17 The American Society for Cell Biology 47th Annual Meeting

December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org 2007 STUDENT AND POSTDOCTORAL AWARDS

ASCB Merton Bernfi eld Memorial Award ASCB Norton B. Gilula Memorial Award

Dawen Cai Ethan Garner University of Michigan Medical School University of California, San Francisco Supported by Rockefeller University Press Invited Talk Invited Talk (Minisymposium 15) Monday, December 3, Room 147 (Minisymposium 13) Monday, December 3, Ballroom B In Vitro and In Silico Reconstitution of DNA Segregation: A 3 Component, Post-translational Modifi cations of Direct the Preferential Kinetically Self-contained Plasmid DNA Segregating Spindle Transport of Single Kinesin-1 Motors in Live Cells

British Society for Cell Biology Molecular Biology of the Cell Young Cell Biologist of the Year Paper of the Year Award

Michelle Welsh Ronald Lebofsky Medical Research Council Human Reproductive Sciences Unit Harvard Medical School Poster Award Presentation and Invited Talk (Board 373) Tuesday, December 4, Hall A/B (Minisymposium 2) Sunday, December 2, Room 146 New Insights into Androgen-dependent Wolffi an Duct Rescue Single-Molecule Analysis Reveals the Distribution of Potential vs. Active DNA in the Male and Female Rat Replication Origins in Human Cells and Xenopus Egg Extracts

ASCB Early Career Life Scientist Award WICB Junior Award

Abby Dernburg Christine Jacobs-Wagner Lawrence Berkeley National Laboratory Yale University

Invited Talk Invited Talk (Minisymposium 23) Tuesday, December 4, Ballroom C (Minisymposium 15) Monday, December 3, Room 147 Cytoskeletal Forces Span the to Mediate Intrinsic Mechanisms Involved in Cell Polarization Dynamics during Meiosis in Caulobacter crescentus

18 The American Society for Cell Biology 47th Annual Meeting

December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

Education Resources/MAC Booth Grand Lobby, Washington Convention Center Saturday, 3:00 pm–5:00 pm Sunday–Tuesday, 9:00 am–5:00 pm Wednesday, 9:00 am–3:00 pm Meet and network with Education and Minorities Affairs Committee (MAC) members, MAC travel awardees, MAC Linkage Fellows, and others. Learn about the ASCB’s latest e-education offerings and attend informal presentations.

Q A new on-demand web seminar series is now available at www.ascb.org/ibioseminars. iBioSeminars is a free-of-charge, open access site that now features 20 seminars from leading scientists; seminars can be viewed by www streaming or downloaded onto a com- puter or iPod.

Q The ASCB Image & Video Library’s online collection contains educational images and videos on cell biology, freely accessible at http://cellimages.ascb.org.

ww.ascb.org/cellweb Presentations Sunday, December 2 2:00 pm–2:45 pm Incorporating New Technology into Online Learning: Applications and Student Satisfaction Kristina Obom and Pat Cummings, Johns Hopkins University 3:00 pm–3:30 pm Teaching Science at a Community College Maria Niswonger, York County Community College

Monday, December 3 1:00 pm–2:00 pm Managing Your Undergraduate Classroom: How to Have Fun and Cope with Problems and Challenges Elisa Konieczko, Gannon University 2:00 pm–2:45 pm The Genomics Education Partnership Sarah Elgin, Washington University in St. Louis 3:00 pm–3:45 pm Microarrays for the Masses: Pedagogical Resources for High School through College Malcolm Campbell, Davidson College

Tuesday, December 4 3:00 pm–3:45 pm Design Principles for Effective Molecular Animations Michelle Reinke and Natalie Greco, Drake University 3:30 pm–4:30 pm United Negro College Fund/Merck Minority Fellowships Jerry Bryant, United Negro College Fund

19 The American Society for Cell Biology 47th Annual Meeting

December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

HOTELS

Hotels Metro Stations 1. Comfort Inn Convention Center– 13. Gallery Place-Chinatown Downtown, DC 14. Judiciary Square 2. Four Points Downtown by Sheraton 15. McPherson Square 3. Grand Hyatt Washington 16. Metro Center 4. Hamilton Crowne Plaza 17. Mount Vernon Square–Convention 5. Hampton Inn DC Convention Center Center 6. Henley Park Hotel 7. Hyatt Regency Washington on Capitol Hill 8. Marriott at Metro Center 9. Morrison-Clark Hotel 10. Red Roof Inn Downtown DC 11. Renaissance Washington, DC Hotel 12. Washington Plaza Hotel

20 The American Society for Cell Biology 47th Annual Meeting

December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

WASHINGTON CONVENTION CENTER Lower Level Concourse Level

21 The American Society for Cell Biology 47th Annual Meeting

December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

WASHINGTON CONVENTION CENTER Lower Level

22 The American Society for Cell Biology 47th Annual Meeting

December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org ACTIVITIES OF SPECIAL INTEREST TO STUDENTS & POSTDOCS

New This Year: Postdocs and students can take advantage of special Monday, December 3 question and answer sessions with Symposia speakers, scheduled 9:30–10:30 am—Congress 101: A Case Study on How to Be an after each Symposium in Room 304. Advocate for Science 9:45–10:15 am—Education Initiative Forum Saturday, December 1 Integrating Quantitative Modeling into Cell Biology 9:00 am–5:00 pm—MAC Mentoring Symposium Raquell M. Holmes, Boston University and University of Connecticut Q 9:00–10:15 am—Opening Plenary, Elma Gonzalez, cell biologist Health Center, and Leslie M. Loew, University of Connecticut Health and MARC Director at UCLA, shares her story of perseverance to Center inspire and motivate students to believe that they can succeed in the scientifi c research fi eld. 10:00–11:00 am—SCOPT Meeting All postdocs are invited to attend the fi rst hour of the meeting of Q 10:30 am–2:30 pm—Workshop: Writing for Biomedical Publication (waitlisted) the Subcommittee on Postdoctoral Training (SCOPT). Committee members are interested in feedback from postdocs. Q 10:00 am–2:00 pm—Meeting of Minority Undergrads and Early Grads 12:00 Noon–2:00 pm—WICB Career Discussion Lunch 3:00–5:00 pm—MAC Poster Session and Reception 1:00–2:00 pm—Education Resources/MAC Booth Presentation Q 3:00–5:30 pm—Undergraduate Program Managing Your Undergraduate Classroom: How to Have Fun and Q 3:00–3:30 pm—Poster Set Up Cope with Problems and Challenges Q 3:30–4:30 pm—Seeing in the Dark: How Fluorescent Proteins Are Elisa Koneiczko, Gannon University Shaping Biology Jennifer Lippincott-Schwartz, National Institute of Child Health and 2:00–3:00 pm—Congressional Liaison Committee Seminar Human Development/NIH Mock Congressional Offi ce Meetings Q 4:30–5:30 pm—Undergraduate Poster Presentations and light 2:00–3:00 pm—National Science Foundation Grant Opportunities in refreshments Biological Sciences and Educational Activities 6:00 pm—Keynote Symposium: New Biologists for the New Biology 2:00–2:45 pm—Education Resources/MAC Booth Presentation William Bialek, Princeton University, and Shirley Ann Jackson, The Genomics Education Partnership Rensselaer Polytechnic Institute Sarah Elgin, Washington University at St. Louis

7:30–9:30 pm—Opening Night Reception 3:00–3:45 pm—Education Resources/MAC Booth Presentation Microarrays for the Masses: Pedagogical Resources for High School Sunday, December 2 through College 9:45–10:15 am—Bruce Alberts Award Presentation A. Malcolm Campbell, Davidson College Catalyzing Changes in Undergraduate Science Education Patricia J. Pukkila, University of North Carolina at Chapel Hill 5:30–6:30 pm—Practice of Science: Challenges and Opportunities for NIH Peer Review 12:00–2:00 pm—Postdoc Workshop: Getting Out of the Box: –8:00 —WICB Evening Program & Awards Presentation Transitioning to a Career Beyond Academic Research 6:30 pm 2:30–3:30 pm—Women in Cell Biology (WICB) Network Reception Tuesday, December 4 9:45–10:15 am—Education Initiative Forum 12:30–2:00 pm—High School Program Encouraging Students to Develop Scientifi c Thinking Skills: New Getting in Shape: New Clues from the Fly Embryo Methods for Assessing Performance Jennifer Zallen, Sloan-Kettering Institute Elisa Stone, Berkeley High School 2:00-2:45 pm—Education Resources/MAC Booth Presentation 3:00-3:45 pm—Education Resources/MAC Booth Presentation Incorporating New Technology into Online Learning: Applications Design Principles for Effective Molecular Animations and Student Satisfaction Michelle Reinke and Natalie Greco, Drake University Kristina Obom and Pat Cummings, Johns Hopkins University 1:30–3:00 pm—Conversation with NIH: Scientifi c Workforce Issues: 3:00–3:30 pm—Education Resources/MAC Booth Presentation Nuts and Bolts Teaching Science at a Community College 6:00 pm–7:00 pm—CellSlam 2007 Maria Niswonger, York County Community College 7:00–8:00 pm—Public Service Award Presentation and Address Wednesday, December 5 U.S. Representative Michael Castle (R-DE) 9:45–10:15 am—Education Initiative Forum Yeast and Oxygen: Incorporating Functional Genomics Research into Three Integrated Undergraduate Laboratory Classes Clare O’Connor, Boston College 23 The American Society for Cell Biology 47th Annual Meeting

December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org AUTHOR DISCLOSURES

The ASCB requires that audiences be informed of presenters’ (speakers, Disclosure Key authors, and contributors) academic and professional affi liations, A. Stock options or bond holdings in a for-profi t corporation or self- and the disclosure of the existence of any signifi cant fi nancial interest directed pension plan or other relationship presenters have with the manufacturer(s) of B. Research grants any commercial product(s) discussed in a presentation. This policy C. Employment (full- or part-time) allows the listener/attendee to be fully informed in evaluating the D. Ownership or partnership information being presented. Disclosure includes any relationship E. Consulting fees or other remuneration that may bias one’s presentation or which, if known, could give the F. Non-remunerative positions of infl uence such as offi cer, board perception of bias. These situations may include, but are not limited member, trustee, or public spokesperson to: 1) stock options or bond holdings in a for-profi t corporation or G. Receipt of royalties self-directed pension plan, 2) research grants, 3) employment (full- or H. Speakers bureau part-time), 4) ownership or partnership, 5) consulting fees or other remuneration, 6) non-remunerative positions of infl uence such as The following have disclosed relationships. Additional information offi cer, board member, trustee, or public spokesperson, 7) receipt of may be obtained from the ASCB National Offi ce, telephone (301) royalties, 8) speakers bureau. 347-9300; [email protected].

Author Organization–Disclosure Author Organization–Disclosure

Ahmad, Rili National Institutes of Health, Institute of Aging—C Demir, Özlem TUBITAK and TWAS to AKarabay and TUBITAK to Alworth, Samuel SVision LLC—C I. Aksan-Kurnaz—B Amidi, Fataneh p50-011999 and 8116—B Dentler, William University of Kansas—C Andersen, Tim Crowley Davis Research—C Dodson, Matt NSF 348327—B Arikawa, Emi SuperArray Bioscience Corp—C Dowler, Thomas and Stroke Foundation of Canada—B; Aziz, Arif NSERC of Canada to JCM—B Canadian Institute of Health Research—B Barbolina, Maria Ovarian Cancer Research Foundation—B Drechsler, Hauke Boehringer Ingelheim Fonds—B Penny Severns Breast, Cervical, and Ovarian Cancer Elias, Kathleen Cytokinetics, Inc.—A Research Fund—B Cytokinetics, Inc.—C Beacham, Dan Molecular Probes Invitrogen—C Evans, Mark Diabetes UK—B Bhanot, Kunal CIHR—B Ferreri, Deana R01-HL-68079; T32-HL-07194—B Bowen, James LifeSensors, Inc.—C Fujimura, Ken JSPS Research Fellowship for Young Scientists (DC1)—B Brigstock, David NIH RO1 AA12817—B Fujita, Satoshi NEDO of Japan—B Brigstock, David Ben Bryer Trust—B Gannon, Patrick NIH AREA—B Brown, Sherry-Ann NIH Grant RR013186—B Gentalen, Erik Cell Biosciences—A Burkhardt, Janis Lupus Research Institute—B Gupta, Sita NIH to T.M.D and J.M.H—B; NSF MCB-031346 to Tobacco Settlement Funds from the Commonwealth T.M.D—B of Pennsylvania—B Han, Gongshe NIH to T. M. D and J.M.H—B; NSF MCB-031346 Campbell, A Malcolm NSF—B to T.M.D—B HHMI—B Heda, Ghanshyam This work supported by the Offi ce of Research and Waksman Foundation for Microbiology—B Development, Medical Research Service—Department Cardoso, Alexandre FAPESP/CNPQ/FAEPEX—B of Veterans Affairs to CR.M.—B Carlisle, Diane Flight Attendants’ Medical Research Institute V.A Medical Center and The University of Tennessee Grant—B Health Sciences Center at Memphis—C NHLBI T15HL074353—B Holvey-Bates, Elise Pennsylvania Academy of Science Undergraduate Carvalho, Hernandes FAPESP/CNPQ/FAEPEX—B Research Award—B Cavicchia, Juan Carlos CONICET (Argentina National Research Council) Hong, Mansoo NIH RO1 and Udall Supplements—B and CIUNC (Cuyo-Argentina National University Hoskins, Sally NSF CCLI—B Council)—B Johnson, J. BioForce Nanosciences—C Chan, Pamela Genentech, Inc.—A Johnson, Jill NIH/NCRR P20 RR15587—B Genentech, Inc.—C Johnson, L. Jeffrey Echelon Biosciences Inc.—C Chang, Wakam NIH grant RO-1 DK-25387 (MSM)—B Kang, Shin-Sung KOSEF (R01-2006-000-10756-0)—B Chen, Buxin National Science Foundation Grant Kanungo, Jyotshna Mason Trust Fund, Medical College of Georgia MCB-0614772—B –Augusta—B Chen, Xinhua This work is supported by the U.S. Air Force Offi ce Kasili, Paul Cambridge Research & Instrumentation—B; of Scientifi c Research. This study is also a joint project Cambridge Research & Instrumentation—C supported by a grant from the National Key Basic Katti, Christiana NSF—B Research Program of China (no. 2003CB515)—B Kellard, Libby Millipore Corporation—C Choi, Ik Sung BioGreen21, Korea RDA—B Kendall, Stephen Millipore Corporation—C Colombini, Marco NIH, NSF grants—B Kim, Ho-Shik This work was supported by MRC grants R13-2002- Davé, Rahul NIH T32-HL07692—B 005-01003-0 from Korea Science and Engineering de Jesus Perez, Vinicio ALA Postdoctoral Fellowship—B Foundation—B

24 The American Society for Cell Biology 47th Annual Meeting

December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org Author Organization–Disclosure Author Organization–Disclosure

Kotula, Leszek NIH-DOD—B Quinlan, Roy British Eye Research Foundation—B Lai, Chun-Wei Ellison Medical Foundation: New Scholar- Aging—B Ramos, Joe NIH/NCI R01CA093849—B Lamers, Marcelo CAPES #5181-06-2—B; FAPESP #2006/57508- Rash, John NIH—B 2—B CIHR—B Larkin, Shannon SurModics, Inc.—C Reiner, Orly Israeli Science Foundation–Foundation Jérôme Corning, Inc.—D Lejeune, Minerva Fundation–German-Israeli Donaldson, Inc.—D collaboration grant, March of Dimes—B Lee, Brian Association Française contre les Myopathies—B Rho, Jaerang KRFG: C00154-C00283-BK21—B Charley’s Fund—B; Strategic Research Fund Rojas, Angela Universidad Nacional de Colombia—B (KCOM)—B Rosenwald, Anne NSF—B Lee, Chi Muscular Dystrophy Association research grant Russel, Deborah Ellison Medical Foundation: New Scholar–Aging—B 3682—B Salisbury, Jerrod Millipore Corporation—C Lee, Dong-Hee BioGreen 21—B Schiffenbauer, Yael Cell Kinetics—C Lee, Jeong Goo NIH/NEI 06431 and 03040 - and Research to Scott, Brenton Pulmotect—D Prevent Blindness—B Shaffer, Meredith NIH Developmental Biology Training Grant, 5-T32- Lee, Jung Weon Funded by KOSEF R01-2006-000-10248-0 to JW HD07516-09—B Lee—B NIH Cell and Molecular Biology Training Grant Lee, Jung Weon This work was supported by a KRIBB fund GM7229-29—B (KGM2110711 to H-G Lee) and a Korea Research Sheridan, Steven Millipore—C Foundation Grant (KRF-2006-311-C00491 to J W Shin, Won-Sik Korea Research Foundation Grant and Korea Science Lee)—B and Engineering Foundation (SUF)—B Leonard, Michelle NIH: EY10577—B Simon, Sanford NSF BES-0620813, NIH P20 GM072015—B NIH: EY04258—B Singer, Matthew Millipore Corporation—C NIH: EY014798—B Sloboda, Roger NSF MCB-0418877—B NIH: T32E5007283—B NIH DK-071720—B Lingle, Wilma The Breast Cancer Research Foundation—B Snapp, Erik AECOM Center for AIDS Research-Ellison Medical DAMD Breast Cancer Research Program—B Foundation, R21 DK074650-01—B Mayo Clinic Breast Cancer SPORE—B Solataninassab, Syrus Platypus Technologies, LLC—C Liu, Jianhua This work was supported by the Agency for Science, Stosik, Magdalene amaxa AG—C Technology and Research (A-STAR), Singapore—B Subramani, Suresh NIH DK41737—B Malowney, Andrew NIH Grant R37 GM29994—B Tague, Sarah HD049615—B Meili, Ruedi University of California, San Diego—C Travis, Alexander NIH HD045664—B Meiners, Sally Donaldson Co., Inc.—B Urban, Michael Bio-Rad Laboratories—C Menko, Allyn NIH: EY10577—B Vail, Mason Crowley Davis Research—C NIH: EY04258—B Vanden Bosch, An Fellow of the Instituut voor de aanmoediging van NIH: EY014798—B Innovatie door Wetenschap en Technologie in NIH: T32E5007283—B Vlaanderen—B Millman, Gregory Association Française contre les Myopathies—B Varughese, Bridget NSF—B Biomedical Sciences Graduate Research Program Verghese, Divya Department of Biotechnology-Government of Grant (GWM)—B India—B Charley’s Fund—B Vidal, Benedicto Fudação de Amparo à Pesquisa do Estado de São Paulo Strategic Research Fund (KCOM)—B e CNPq—B Mishima, Toshiaki MEXT of Japan (19370079)—B Wang, Jian Flexcell International Corp.—C Mogami, Toshifumi JSPS fellow—B Wang, Kai NIH—B Mollapour, Elahe NIEHS/NIH—C Wang, Weiping USPHS National Institute of Health—B Moniz, David CIHR operating grant MOP/77616—B Wang, Yang Hong Kong Research Council grant (HKU7609/06M) Mountzouris, John Abgent—C and HKU/CRCG Seed Funding—B Nachury, Maxence Genentech—C Webber, Elizabeth Supported by NIH grants NS050650 and Newell-Litwa, Karen Sigma Xi Grant-In-Aid of Research—B NS047575—B NIH NS42599 and GM077569—B Weill, Claire Polyplus-Transfection—C Nystrom, Erik Olink Bioscience—C Wright, Robin NSF—B Oates, Jessica NIH AREA—B Yan, Jizhou NIH R1 grant—B Ostrovsky, Olga JDRF Postdoctoral Fellowship—B Yeo, Chang-Yeol This work was supported by a Korean Research Otter, Tim Crowley Davis Research—C Foundation Grant (KRF-2005-070-C00115) to CYY Palmer, Jeffrey MIT Lincoln Laboratory—C and by BK21 project to YJK and JA—B Paluh, Janet NSF MCB 0616129—B Yi, Kexi NIH Grant R37 GM 29994—B Park, Hay-Oak NIH—B Yoon, Hana Korea Science and Engineering Foundation, through ACS-OH—B the Research Center for Functional Cellulomics—B Peprah, Emmanuel K12-GM00680—B BK21 Program from Ministry of Education and R01-HD29909—B Human Resources Development—B Pérez-Otaño, Isabel Marie Curie International Reintegration grant—B Seoul Science Fellowship—B NARSAD Young Investigator Award—B Zhang, An-Sheng NIH—B Pinto, Belinda Muscular Dystrophy (MDA4221)—B Zhang, Fangliang NIH 547654-2072—B American Heart Association (0615504Z)—B NIH 547774-2072—B Qi, Jie Flexcell Corporation—C Full time, University of Pennsylvania—C Quinlan, Roy NINDS grant P01NS42803 and British Council (ARC project)—B 25 The American Society for Cell Biology 47th Annual Meeting

December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

ASCB Annual Meetings

2008 San Francisco December 13–17 2009 San Diego December 5–9 2010 Washington, DC December 11–15 2011 Denver December 3–7 2012 San Francisco December 15–19

The American Society for Cell Biology 8120 Woodmont Avenue, Suite 750, Bethesda, MD 20814 Tel: (301) 347-9300, Fax: (301) 347-9310 [email protected], www.ascb.org

26 The American Society for Cell Biology

Saturday December 1, 2007

47th Annual Meeting Washington, DC SATURDAY The American Society for Cell Biology 47th Annual Meeting December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

8:30 am –7:00 pm Registration Open (East Registration) )ad 9:00 am –10:15 am Minorities Affairs Committee Mentoring Symposium: Opening Plenary (Room 151)

10:30 am–2:30 pm MAC Workshop: Writing for Biomedical Publication (Room 152B) Lunch provided (Preregistration Required)

12:30 pm–2:30 pm Workshop Offered by the Women in Cell Biology Committee (Room 143 A/B) Time Management—Sandra Schmid, The Scripps Research Institute (Ticket required. If additional tickets become available, they will be sold at the Event Tickets Counter; $15 students/$30 others.)

1:00 pm–5:30 pm Special Interest Subgroups A. Adhesions and (Room 204 A/B) B. Advances in Bone Cell Molecular Biology: Epigenetic Control (Room 204C) C. At the Limits: Optical Methods for Single Molecules, Cells, and Organisms (Room 146) D. Building the Cell (Room 140B) E. Cell Matrix Interactions (Room 140A) F. Cellular Biology of Gap Junction Channels (Room 103A) G. CLASPs Clutching Networks (Room 209 B/C) H. Dynamics of Rafts, Stabilized Rafts, and Other Non-Raft Domains of Membrane (Room 201) I. High Performance Image Analysis and Photomanipulative Techniques for Cell Biology (Room 147) J. Muscle Cytoskeletal Protein Assembly in Normal and Diseased Muscles (Room 145B) K. Recycling Endosomes, A Nexus for Post-Golgi Traffi c (Room 144 B/C) L. Systems Biology of Receptor Kinase Networks (Room 206) M. The NCI Alliance for Nanotechnology in Cancer: Creating Next Generation Nano Tools for Cell Biology (Room 203)

1:30 pm–4:30 pm Education Workshop (Room 152A) Clickers—The Greatest New Teaching Tool Since Chalk: How to Use and Not Misuse Audience Response Systems— William B. Wood, University of Colorado, Boulder

3:00 pm–5:00 pm Minorities Affairs Committee Poster Session/Reception (Room 154)

3:00 pm–5:00 pm Education Resources/MAC Booth Open (Grand Lobby) Daily Schedule—Saturday, December 1 Daily Schedule—Saturday, 3:30 pm–4:30 pm Undergraduate Program (151)

4:30 pm–5:30 pm Undergraduate Poster Presentations/Reception (Room 150B)

6:00 pm Keynote Symposium (Ballrooms A/B/C) New Biologists for the New Biology—William Bialek, Princeton University, and Shirley Ann Jackson, Rensselear Polytechnic Institute

6:00 pm–9:00 pm Posters on Display (Halls A/B)

6:00 pm–9:00 pm Career Center Open (Hall B)

7:30 pm Opening Night Reception (Washington Convention Center) Following Keynote Symposium

28 The American Society for Cell Biology 47th Annual Meeting SATURDAY December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

ASCB Annual Meeting Highlights—Saturday, December 1

Q Minorities Affairs Committee Mentoring Symposium and Poster Session

(Preregistration Required)

Supported by an NIH NIGMS MARC Grant and The Burroughs Wellcome Fund

Elma Gonzalez University of California, Los Angeles (UCLA)

9:00 am–10:15 am Room 151 Opening Plenary. Elma Gonzalez, cell biologist and former Director of UCLA’s Minority Access to Research Careers (MARC) program, will talk about becoming a cell biologist and how her experiences led her to understand the mentoring needs of minority students on their way to successful careers in science.

10:30 am–2:30 pm Room 152B MAC Workshop: Writing for Biomedical Publication, presented by David Morrison, Grant Writers’ Seminars and Workshops, LLC. Lunch provided (advance registration only). This workshop for graduate students, postdocs, and junior faculty is sponsored by the Minorities Affairs Committee (MAC), as part of the annual MAC Junior Faculty Workshop.

3:00 pm–5:00 pm Room 154 Minorities Affairs Committee Poster Session and Reception

Q Workshop Offered by the Women in Cell Biology Committee 12:30 pm–2:30 pm Room 143 A/B (Ticket Required) Supported by the NIH Offi ce of Research on Women’s Health Time Management

Sandra Schmid The Scripps Research Institute This workshop will offer tips to: Q Defi ne short-term and long-term goals Q Develop strategies for managing your time to meet those goals Q Balance your time for research, teaching, and family

If additional tickets become available, they may be purchased at the Event Ticket Counter. ($15 students; $30 others) 29 SATURDAY The American Society for Cell Biology 47th Annual Meeting December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

Q Special Interest Subgroups 1:00 pm–5:30 pm The following member-organized sessions were selected by the ASCB Program Committee. All Annual Meeting attendees are welcome to participate; Annual Meeting registration is required. A. Adhesions and Myosins (Room 204 A/B) that do not result from modifications in DNA nucleotide Richard Cheney, University of North Carolina at Chapel Hill, and Alpha sequences. This session will explore epigenetic lineage transmission Yap, University of Queensland of transcriptional competency (activation and suppression) by Functional cooperation between adhesion receptors and the actin mechanisms that include DNA methylation, histone modifi cations, cytoskeleton underpins many cellular and developmental processes, and mitotic retention of transcriptional regulatory machinery at including cell migration, tissue cohesion and morphogenesis. But the gene loci that are obligatory for cell fate determination. mechanisms responsible for this cooperation remain incompletely Speakers: understood. It is becoming increasingly evident that specific Q Masaki Noda, Tokyo Medical and Dental University, Medical cytoskeletal regulators interact, functionally and biochemically, with Research Institute, Japan both cell-matrix and cell-cell adhesion molecules. Such interactions Q Jane Lian, University of Massachusetts Medical School are often strictly regulated by cell signaling and context, implying Q Gordon Hager, National Cancer Institute/NIH that they serve specifi c cellular and morphogenetic functions. One Q Michael Bustin, National Cancer Institute/NIH important, rapidly developing, area of attention is the relationship Q Gary Stein, University of Massachusetts Medical School between cell adhesion and motors. Three myosins (II, VI, Q Jennifer Westendorf, Mayo Clinic and VII) are already known to interact with a variety of cell adhesion systems (integrins, cadherins) and to exert profound effects on the C. At the Limits: Optical Methods for Single Molecules, Cells, and Organisms biology of those adhesion receptors. Accordingly, we believe that this (Room 146) is an ideal time to bring together investigators working in adhesion Jason Swedlow, University of Dundee, United Kingdom, and Jennifer and myosin biology, to thereby encourage in-depth discussion at Waters, Harvard Medical School the interface between these two fi elds. Supported by: Optical Imaging Association Speakers: Light microscopy is a critical tool for cell biology. Its applications Q Myosin II as a Master Regulator of Cell Migration. Miguel have extended from traditional fi xed cell analysis to include the Vincente-Manzares and Alan R. Horwitz, University of study of molecular interactions in living cells and isolated molecules. Virginia This session, sponsored by the Optical Imaging Association (OPIA), Q The Role of Nonmuscle Myosin II in Mouse Development and will explore the latest applications of optical microscopy. The Disease. Robert Adelstein, National Heart, Lung, and Blood speakers are pulled from the best imaging labs in the world and Institute/NIH will provide a broad coverage of light microscopy “at the limits.” Q Myosins and Morphogenesis: Myosin II Regulates Cytoskeleton, Cell Behavior, and Adhesion during Xenopus Convergence Speakers: and Extension. Paul Skoglund and Ray Keller, University of Q Evaluating Performance in 3-D Fluorescence Microscopy. John Virginia Murray, University of Pennsylvania Q Myosin-dependent Cell Spreading and Area Increase. Nils Q Single Molecule Imaging of Molecular Motors. Samara Reck- Gauthier, Olivier Rossier, and Michael P. Sheetz, Columbia Peterson, Harvard Medical School University Q Protein Organization within the Kinetochore by Speckle High Q Myosin-X, the Filopodial Tip Complex, and a Novel Form Resolution Co-localization (K-SHREC). Ted Salmon, University of Motility in Filopodia. Richard Cheney, University of North of North Carolina at Chapel Hill Carolina at Chapel Hill, Chapel Hill Q Chemical Probes and Targeting Methods for Imaging of Protein Q Myosin VI and Morphogenesis of Cell-Cell Contacts. Alpha Function in Living Cells. Alice Ting, Massachusetts Institute of Yap, University of Queensland, Australia Technology Q Talin Regulates Myosin VII Dynamics. Meg Titus, University of Q Multidimensional Fluorescence Imaging. Paul French, Imperial Minnesota College, United Kingdom Q Use of Biosensors to Track the Initiation of Cell Motility in B. Advances in Bone Cell Molecular Biology: Epigenetic Control Tumor Cells in vitro and in vivo. Jacco van Rheenen, Albert (Room 204C) Einstein College of Medicine Jane Lian, University of Massachusetts Medical School, Masaki Noda, Q Chronic and Portable Microscopy in Freely Moving Mice. Mark Tokyo Medical and Dental University, Medical Research Institute, Japan, Schnitzer, Stanford University and Gary Stein, University of Massachusetts Medical School D. Building the Cell (Room 140B) Both genetic and epigenetic control contribute to combinatorial Wallace Marshall, University of California, San Francisco regulation of cell growth, proliferation, and tissue-specifi c gene expression for skeletal development, repair, and remodeling. Modern cell biologists have made great strides in understanding cell Epigenetic control is mediated by heritable changes in phenotype structure and function. As with any engineering problem, however,

30 The American Society for Cell Biology 47th Annual Meeting SATURDAY December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

there is a third important aspect that needs to be understood besides Q Integrin Signaling and Cancer. Martin Schwartz, University of structure and function, and that is assembly. How are the complex Virginia three-dimensional structures found within the cell specifi ed by Q Microenvironmental Regulation of . Alissa Weaver, a one-dimensional genome? In this session we will explore the Vanderbilt University mechanisms by which cellular structures are determined and Q Plasticity of Cancer Invasion Programs in vivo. Peter Friedl, regulated. Because this question lies at the interface of biology and University of Würzburg, Germany physics, we propose a highly interdisciplinary session with speakers whose interests range from soft matter physics and mathematical F. Cellular Biology of Gap Junction Channels (Room 103A) modeling to imaging and cell biology. Linda Musil, Oregon Health & Science University Speakers: Present in virtually all cell types in animals ranging from cnidarians Q Cells Taking Shape: Global Coordination of Cytoskeletal to humans, gap junctions are involved in a variety of fundamental Mechanics, Adhesion, and Shape Determination in Rapidly processes including regulation of cellular differentiation, growth Moving Cells. Julie Theriot, Stanford School of Medicine control, embryonic development, and specialized tissue function. Q Infl uence of Confi ned Volume on Microtubule Dynamics. Holly Defects in the proteins that comprise gap junctions have been linked Goodson, University of Notre Dame to several human diseases. This session is the 13th consecutive Q Pushing, Pulling, and Sticking: Studying the Mechanics of Cell meeting of this subgroup, which is now widely recognized to be the Movement. Arpita Upadhyaya, University of Maryland primary annual forum for gap junction research in the U.S. The Q Dynamic Organization of the Budding Yeast Mitotic Spindle. session will address new developments in our understanding of gap David Odde, University of Minnesota junction diversity, assembly, regulation, channel structure/function, Q Microchannels, Microtubules, and Cell Shape. Phong Tran, and role in physiological processes. University of Pennsylvania Speakers: Q Assembly of a Contractile Ring in Fission Yeast: Dynamics and Q Movement of M3 Helices during Gating of Cx43 Gap- Topology of a Condensing Actomyosin Network. Dimitrios Junctional Hemichannels by PKC-mediated Phosphorylation. Vavylonis, Lehigh University Guillermo Altenberg, Texas Tech Health Sciences Center Q Reconstituted Cytoskeletal Systems: Self-organization and Q Non-healing Corneal Recovery Triggered by Regulation of Mechanics. Mireille Claessens, Technische Universitaet Direct Cell-cell Communication. Kaa-Sandra Chee, University Muenchen, Germany of Auckland, New Zealand Q Cellular Hydraulics: Water, Water Everywhere, Nor Any Drop Q Vesicles Containing Cx32 Isolated from Liver Traffic on to Drink. L. Mahadevan, Harvard University Microtubules in vitro. Alfredo Fort, Albert Einstein College of Q Stable Segregation of PAR Proteins in the Early C. elegans Medicine Embryo Relies on a Bistable Switch Mechanism. Adriana Dawes, Q Cx43 Modulates Polarized Cell Morphology and Directional Center for Cell Dynamics, University of Washington Cell Migration through Tubulin Interaction and the Assembly of Stabilized Microtubules. Richard Francis, National Heart, E. Cell Matrix Interactions (Room 140A) Lung, and Blood Institute/NIH Muhammad H. Zaman, University of Texas at Austin Q Internalization of Gap Junctions Requires the Clathrin Numerous symposia and minisymposia at the ASCB Annual Dependent Endocytic Machinery. Anna Gumpert, Lehigh Meeting have addressed adhesion, migration, and signaling University individually, but the multidisciplinary and complex landscape Q Altered Permeability of Cx26 Non-syndromic Deafness of cell matrix interactions incorporating mechanics, signaling, Associated Mutants. Gulistan Mese, SUNY Stony Brook adhesion, migration, and proteolysis has never been addressed. This Q Involvement of Phosphorylation in C-terminus in Regulation subgroup aims to fi ll this void. Through a diverse set of speakers of Cx46 Connexons. Anaclet Ngezahayo, Leibniz University, who will address novel approaches to quantify and analyze cell Germany matrix interactions, we will address these complex processes from Q Endocannabinoids Evoke PKA-dependent Potentiation of Cx35- both a quantitative computational and an experimental perspective. mediated Electrical Synapses. Alberto Pereda, Albert Einstein The presentations will focus on several key areas in cell matrix College of Medicine interactions, namely interactions at the molecular and cellular Q Mechanism of Cx26 Induced Increased Migration in HeLa Cells. level, matrix and cellular mechanics, pericellular proteolysis, and Srikanth Polusani, University of Texas Health Science Center at the effects of substrate chemical and physical properties regulating San Antonio these processes. Speakers: G. CLASPs Clutching Microtubule Networks (Room 209 B/C) Fred Chang, Q A Unifi ed Mechanism for Force, Rigidity, and Speed Sensing. Columbia University College of Physicians and Surgeons, and Yu-Li Wang, University of Massachusetts Medical School Irina Kaverina, Vanderbilt University Medical Center Q Molecular Mechanics of Cell Adhesion. Muhammad H. Zaman, Diverse processes such as and directed cell migration University of Texas at Austin require spatial regulation of microtubule stability. CLASPs have Q Rules and Dynamics in Cell-Matrix Interactions. Kenneth Yamada, emerged in the last few years as key factors responsible for local National Institute of Dental and Craniofacial Research/NIH microtubule stabilization. Recent evidence suggests that they 31 SATURDAY The American Society for Cell Biology 47th Annual Meeting December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

organize dynamic microtubule networks by inhibiting microtubule Speakers: depolymerization and promoting rescue. Although best known for Q Oligomerized Caveolin-1 Micro Domains, the Galectin Lattice their functions at the microtubule plus ends and kinetochores, these and the Regulation of Cell Surface Receptor Signaling and proteins are also targeted to other sites such as zones of microtubule Dynamics. Ivan R. Nabi, University of British Columbia overlap, cell cortex, neuronal growth cones, centrosomes and the Q Live Cell Photo-activation Localization Microscopy (PALM) for Golgi apparatus. At these locations, CLASPs contribute to building the Spatio-temporal Mapping of Single Molecule Diffusion in specialized microtubule structures and regulating their dynamic the Plasma Membrane. Jennifer Lippincott-Schwartz, National behavior. This meeting will highlight exciting advances on CLASP Institute of Child Health and Human Development/NIH biology from many perspectives and model organisms. Q PV1—a Novel Marker of Caveolar Endocytosis. R.V. Stan, Speakers: Dartmouth Medical School Q Molecular Mechanisms of Cortical Microtubule Attachment. Q Distribution and Lateral Mobility of DC-SIGN on Immature Anna Akhmanova, Erasmus MC, The Netherlands Dendritic Cells. Aaron Neumann, University of North Carolina Q Stabilization of Overlapping Microtubules in S. pombe. Scott at Chapel Hill Bratman, Columbia University Q Cellular Responses to Transfer of Cholesterol from Q Functional Analysis of Mammalian CLASP. Niels Galjart, to Macrophages. Frederick R. Maxfi eld, Weill Cornell Medical Erasmus MC, The Netherlands College Q Stu1 in Spindle Assembly in S. cerevisiae. Tim Huffaker, Cornell Q Intersectin-2L is a Regulator of Internalization in University Endothelial Cells. Irene Klein, University of Illinois Q CLASPs at the Trans Golgi Network Membrane. Irina Kaverina, Q TBA. Mark A. McNiven, Mayo Clinic College of Medicine Vanderbilt University Medical Center Q Additional speakers pending Q Regulation of CLASP and Microtubule Dynamics by GSK3beta in Planar Polarized Epithelial Cells. Praveen Kumar, University of California, San Francisco I. High Performance Image Analysis and Photomanipulative Techniques for Q A New Flux of CLASPs and ASPs during Mitosis. Helder Maiato, Cell Biology (Room 147) University of Porto, Portugal Ken Jacobson, University of North Carolina at Chapel Hill, and Michael Mancini, Q Abelson Tyrosine Kinases Signaling during Axon Guidance and Baylor College of Medicine its Regulation of CLASP. David Van Vactor, Harvard Medical Advances in light microscopic imaging of cells have ushered in a new School era in cell biology, and have increased awareness and development of systems level biology at the single cell level. One focus of H. Dynamics of Rafts, Stabilized Rafts, and Other Non-Raft Domains of this workshop will be on the utilization of these technologies to Membrane (Room 201) quantitatively investigate gene regulation, mRNA splicing, stem cell Dan Predescu, University of Illinois differentiation, and the extracellular matrix. A second focus will The smooth omega-shaped plasmalemma proper invaginations be on biosensors that provide subcellular readouts of key signaling discovered and named plasmalemmal vesicles (PVs) by Palade in molecules and on photomanipulative techniques, including the 1953 were the fi rst type of vesicular carriers involved in transport photoactivation of caged compounds or chromophore assisted at the cellular level. PVs are the structural and functional basis laser inactivation (CALI or FALI) of selected components, as of cellular transport processes like endocytosis and transcytosis an important complement to traditional genetic manipulations. found in nearly all cell types. Beside the reality of different types Talks will range from high throughput imaging efforts that of structurally defi ned vesicular carriers, the existence of membrane capitalize on automated image acquisition and image analyses to rafts is so tempting and so signifi cant that a “Raft-centric” view of photomanipulative studies on the subcellular scale. membrane structure has been advanced. However, such an exclusive Speakers: point of view could distort the certainty of membrane diversity. Both Q Burnham MLSCN Screening Center Update and Automated PVs (caveolin-based as well as caveolin- and clathrin-independent) Stem Cell Tracking. Jeffrey H. Price, Burnham Institute for and membrane rafts have been implicated in cellular transport (viral Medical Research and toxin entry, protein and lipid traffi cking), in cellular signaling, Q High Throughput Image Analyses of Nuclear Receptor Function. and in shaping the structural heterogeneity of membrane micro Michael A. Mancini, Baylor College of Medicine domains. For caveolin-based as well as for caveolin- and clathrin- Q In vitro FRAP and the Study of mRNA Export. Jeffrey A. independent PVs, their characteristic morphology is still the decisive Nickerson, University of Massachusetts Medical School factor for describing them; for rafts, at present time, their function Q Gene Targeting by Nuclear Receptors in Living Cells. Gordon L. is an important aspect used to defi ne them. This subgroup meeting Hager, National Cancer Institute/NIH proposes to address and discuss the varied and multiple aspects of Q New Tools for Multiplex Manipulation and Visualization of caveolin-based, caveolin-independent, and raft traffi cking in the Protein Activities in Living Cells. Klaus Hahn, University of cell. North Carolina at Chapel Hill Q Light-sensitive Sensors and Modulators of Intracellular . David Lawrence, University of North Carolina at Chapel Hill

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Annual Review of Cell and Developmental Biology® Contents and Authors • Following the Chromosome Path to the Garden of the Genome, Volume 23, November 2007 Mary-Lou Pardue Available Online and in Print • Penetration of Nonenveloped Viruses into the Cytoplasm, Billy Tsai • Heart Field: From Mesoderm to Heart Tube, Radwan Abu-Issa, Margaret L. Kirby http://cellbio.annualreviews.org • Transcriptional Control of Wound Repair, Matthias Schäfer, Sabine Werner • Mechanisms Regulating Epithelial Stratification, Maranke I. Koster, Dennis R. Roop Editor: Randy Schekman • Two Families of Chaperonin: Physiology and Mechanism, Arthur L. Horwich, University of California, Berkeley Wayne A. Fenton, Eli Chapman, George W. Farr • SNARE-Ware: The Role of SNARE-Domain Proteins in Plant Biology, The Annual Review of Cell and Developmental Volker Lipka, Chian Kwon, Ralph Panstruga Biology, in publication since 1985, covers the significant • microRNA Functions, Natascha Bushati, Stephen M. Cohen • Embryonic Patterning in Arabidopsis thaliana, Pablo D. Jenik, C. Stewart Gillmor, developments in the field of Cell and Developmental Wolfgang Lukowitz Biology, including structure, function, and organization • Structure and Mechanism of Cadherins and Catenins in Cell-Cell Contacts, of the cell, development and evolution of the cell as it Sabine Pokutta, William I. Weis relates to single and multicellular organisms, and models • Semaphorin Regulation of Cellular Morphology, Tracy S. Tran, Alex L. Kolodkin, and tools of molecular biology. Rajnish Bharadwaj • Wing Vein Patterning in and the Analysis of Intercellular Signaling, This journal is ideal for cell and developmental Seth S. Blair biologists as well as those in the fields of • Maintaining Peroxisome Populations: A Story of Division and Inheritance, and biochemistry. Andrei Fagarasanu, Monica Fagarasanu, Richard A. Rachubinski • Cilia and Developmental Signaling, Jonathan T. Eggenschwiler, Kathryn V. Anderson The Annual Review of Cell and Developmental • Calcium Signaling in Neuronal Motility, James Q. Zheng, Mu-ming Poo Biology is ranked #1 by impact factor of the 34 • Controls of Germline Stem Cells, Entry into Meiosis, and the Sperm/Oocyte Developmental Biology publications assessed and #4 Decision in , Judith Kimble, Sarah L. Crittenden by impact factor of the 156 Cell Biology publications • Hyaluronan in Tissue Injury and Repair, Dianhua Jiang, Jiurong Liang, Paul W. Noble assessed by the ISI® Journal Citation Reports (JCR®). • The Thymus as an Inductive Site for T Lymphopoiesis, Maria Ciofani, Juan Carlos Zúñiga-Pflücker PERSONAL COPIES AVAILABLE AT A REDUCED RATE. INSTITUTIONAL PRICING AND SITE LICENSE OPTIONS AVAILABLE. CONTACT ANNUAL REVIEWS FOR DETAILS. • Secretory Mechanisms in Cell-Mediated Cytotoxicity, Jane C. Stinchcombe, Gillian M. Griffiths • Biogenesis and Function of Multivesicular Bodies, Robert C. Piper, Access this and all Annual Reviews David J. Katzmann series immediately via your institution at • Morphology, Molecular Codes, and Circuitry Produce the Three-Dimensional www.annualreviews.org Complexity of the Cerebellum, Roy V. Sillitoe, Alexandra L. Joyner • The Small G Proteins of the Arf Family and Their Regulators, ANNUAL REVIEWS Alison K. Gillingham, Sean Munro A Nonprofit Scientific Publisher • The Cell Biology of Synaptic Plasticity: AMPA Receptor Trafficking, Call: 800.523.8635 (Toll Free US/CAN) Jason D. Shepherd, Richard L. Huganir Call: 650.493.4400 (Worldwide) • The Role of Pax Genes in the Development of Tissues and Organs: Pax3 and Fax: 650.424.0910 Pax7 Regulate Muscle Progenitor Cell Functions, Margaret Buckingham, Frédéric Relaix Email: [email protected] • The Biology of Cancer Stem Cells, Neethan A. Lobo, Yohei Shimono, Order online at www.annualreviews.org Dalong Qian, Michael F. Clarke Winner of the AAP Professional and Scholarly Publishing Division 2006 Award for Innovation and Journal Publishing www.acschemicalbiology.orgwww.acschemicalbiology.org

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The American Society for Cell Biology 47th Annual Meeting SATURDAY December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

Q Spatio-temporal Control of Protein Activity and Expression in Speakers: Living Cells. Dan Larson, Albert Einstein College of Medicine Q Retrograde Toxin Traffi c through the Recycling Endosome. Q On the Use of EGFP as a CALI Agent to Induce Loss of Function David Sheff, University of Iowa in Actin Binding Proteins. Ken Jacobson, University of North Q Polarized Sorting of Receptors in Neuronal Endosomes. Bettina Carolina at Chapel Hill Winckler, University of Virgnia Q Myosin V’s, Microtubules, and Membrane Recycling Systems. J. Muscle Cytoskeletal Protein Assembly in Normal and Diseased Muscles James Goldenring, Vanderbilt University (Room 145B) Q The Role of Endosomes in AP-1B Mediated Basolateral Sorting. Carol C. Gregorio, University of Arizona, and Joseph W. Sanger, SUNY Heike Folsch, Northwestern University Upstate Medical University Q Role of Rab10 in Membrane Traffi c of Epithelial Cells. Kenneth Dunn, Indiana University This session will include several short presentations on the latest Q Exocyst Function in Apical Recycling and Basolateral-to-Apical advances in investigating the architecture of cardiac and skeletal Transcytosis. Gerard Apodaca, University of Pittsburgh muscle during normal development and in disease. Myofi bril Q Association of C-terminal EHD Proteins with Lipid Membranes: assembly at its most basic level requires assembly of actin and myosin A Structural Outlook. Steven Caplan, University of Nebraska proteins into fi laments that can interact to produce contractile force. This only happens, however, in conjunction with the coordinated L. Systems Biology of Receptor Tyrosine Kinase Networks (Room 206) interactions of a plethora of structural and regulatory proteins Peter Sorger, Harvard Medical School, and H. Steven Wiley, Pacifi c that must become localized in precise arrays to allow contractile Northwest National Laboratory force to occur in a regulated manner. Studies to defi ne the roles of these muscle proteins and identify their interactions are crucial Receptor tyrosine kinases (RTKs) are central components of cell for understanding myofibrillogenesis and how this precisely signaling networks and play crucial roles in normal physiological coordinated process is often perturbed in human myopathies. processes, such as embryogenesis, cell proliferation, and apoptosis. Speakers: Dysregulation of RTK signaling underlies many human diseases, Q Introductory Remarks. Joseph Sanger, SUNY Upstate Medical but these networks are enormously complex with multiple positive University and negative feedback loops, hindering efforts to design targeted Q Changing Protein Dynamics during Myofi brillogenesis. Jushuo therapies. The application of systems biology is a promising Wang, SUNY Upstate Medical University approach for improving our understanding of RTK networks. Q Lasp-2 Expression, Localization, and Ligand Interactions: a New However, this fi eld is in its infancy, and researchers have only Z-disc Scaffolding Protein. Anke Zieseniss, University of Arizona, recently started developing realistic mathematical models and Tucson acquiring the large amounts of quantitative data necessary to test Q Matrix Elastic Effects in . Adam Engler, University their predictions. This subgroup brings together computational and of Pennsylvania experimental biologists who are working to unravel these networks Q Insight from C. elegans on Molecular Linkages between the and will discuss current issues and approaches in this research Surface and the . Guy M. Benian, Emory area. University Speakers: Q ’s M-band Region in Sarcomere Assembly and Maturation. Q Quantitative Analysis of ErbB Cellular Signaling Networks. Michael Gotthardt, Max-Delbrück-Center for Molecular Forest White, Massachusetts Institute of Technology Medicine, Germany Q Protein Microarray Technology as a Tool for Examining ErbB Q Determinants of Titin Isoform Switching in RTK Signaling at a Systems Level. Richard B. Jones, University Development. Wolfgang A. Linke, Universitaet Münster, of Chicago Germany Q Modularity, Feedback, and Recursion in the EGF Receptor System. Q Characterization of Cellular and Titans. Thomas H. Steven Wiley, Pacifi c Northwest National Laboratory Keller, III, Florida State University Q Modeling Snap-action and Failure Modes of a Switch Controlling Extrinsic Cell Death. Peter Sorger, Harvard Medical School K. Recycling Endosomes, A Nexus for Post-Golgi Traffi c (Room 144 B/C) Q Using a Systems Biology Approach to Decipher the Role of David Sheff, University of Iowa Feedback Loops in IGF1R Signaling. Birgit Schoeberl, Merrimack The recycling endosome is emerging as a nexus of apical and Pharmaceuticals basolateral endocytic traffic, basolateral secretory traffic, and Q Systematic Analysis of Crosstalk in Signal Transduction retrograde traffi c. It is also a warehouse of receptors and membrane Networks. Jason Haugh, North Carolina State University for a wide spectrum of cellular functions including delivery of Q Quantitative Variations in Molecular Networks and the membrane for motility and storage of receptors used in nutrition Emergence of Multicellular Phenotypic Diversity. Anand R. and memory. Passage through the recycling endosome is well Asthagiri, California Institute of Technology documented, but how this sorts traffi c and how storage is Q Rule Based Modeling of Cellular Signaling. Vincent Danos, CNRS, regulated remains elusive. We will explore the structure, function, Université Denis Diderot, France, and Plectix Biosystems and regulation of this organelle.

33 SATURDAY The American Society for Cell Biology 47th Annual Meeting December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

M. The NCI Alliance for Nanotechnology in Cancer: Creating Next Speakers: Generation Nano Tools for Cell Biology (Room 203) Q NCI Alliance for Nanotechnology in Cancer Initiative. Piotr Jerry Lee, National Cancer Institute/NIH Grodzinski, National Cancer Institute/NIH Q Quantitative Assays of Cell Motility, Polarization, and The NCI Alliance for Nanotechnology in Cancer is a comprehensive Cytoskeletal Dynamics. Milan Mrksich, University of Chicago program leveraging nanotechnology for applications in early Q Nanoparticle-based Drug Delivery in Cancer Therapy. David diagnosis and therapy of cancer. On the fundamental level, Sept, Washington University in St. Louis monitoring cell migration and cell growth mechanisms is relevant to Q Nanogenerator for in vivo Biomedical Applications. Zong Ling the understanding of processes contributing to tumor development (ZL) Wang, Georgia Institute of Technology and metastasis. Chip-based nanolabs capable of monitoring and Q Dynamic Surface Gradients for Cell Polarization and Cell manipulating individual cells and nanoscale probes that can track Migration. Muhammad Yousaf, University of North Carolina the movements of cells and biological molecules as they interact with at Chapel Hill their environment are among a few examples of nanotechnology- Q Nanophotonic Probes for Chemical and Physical Imaging inside based tools supporting such studies. The session will showcase Single Live Cells. Raoul Kopelman, University of Michigan nanotechnology developments and subsequent biological studies Q Innovative Approaches for the Imaging of Cancer Metastasis. enabled by these nanotechnology tools and providing means to Leland WK Chung, Emory School of Medicine study, monitor, and alter multiple systems and pathways relevant Q Nano-probes for Detecting and Understanding Pancreatic to the cancer process and to identify key biochemical and genetic Tumorigenesis. Douglas Hanahan, University of California, San effectors at which novel molecular therapies might best be Francisco directed.

Q Education Workshop 1:30 pm–4:30 pm Room 152A (Ticket Required) Sponsored by the Education Committee Clickers—The Greatest New Teaching Tool Since Chalk: How to Use and Not Misuse Audience Response Systems

William B. Wood University of Colorado, Boulder

Want to fi nally learn how to use clickers in the classroom? With the use of iClicker response pads (to be provided), participants will take part in demonstrations and discussion of various ways clickers can be used to facilitate and assess student conceptual understanding. Small working groups will be given a cell biology teaching scenario and asked to create clicker questions, which will then be discussed by the group as a whole. Supplementary reference materials will be provided.

$10 for all attendees; advance online registration; tickets also available onsite at the Event Ticket Counter.

Q Minorities Affairs Committee Poster Session/Reception 3:00 pm–5:00 pm Room 154

34 The American Society for Cell Biology 47th Annual Meeting SATURDAY December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

Q Undergraduate Program 3:30 pm–4:30 pm Room 151 A/B Sponsored by the Education and Local Arrangements Committees Seeing in The Dark: How Fluorescent Proteins Are Shaping Biology

Jennifer Lippincott-Schwartz National Institute of Child Health and Human Development/NIH

One of the most ground-breaking recent discoveries in science has been the use of biofl uorescent proteins. These “visible” molecules can be attached to proteins as molecular tags or labels. Once inside cells or organisms, these tags can be observed in real time and allow the geography, movement, and interaction of proteins to be studied in living tissue. These biofl uorescent proteins are found in nature in luminescent organisms, such as jelly fi sh, bacteria, and beetles. Scientists were able to purify and characterize the light-generating source of several bioluminescent organisms. Later, they discovered another protein, called green fl uorescent protein (GFP), which did not generate light but converted light to a different color. GFP and similar proteins have spurred a revolution in biological research and opened up new avenues of research and investigation. Speaker program will be followed by undergraduate poster presentations and light refreshments. Students are invited to attend the Keynote Symposium following the presentation.

Q Undergraduate Poster Presentations/Reception 4:30 pm–5:30 pm Room 150B

Q Keynote Symposium 6:00 pm Ballrooms A/B/C Supported by the National Science Foundation New Biologists for the New Biology

William Bialek Shirley Ann Jackson Princeton University Rensselaer Polytechnic Institute

6:00 pm Introduction 6:15 pm 1 The Other Half of Western Civilization: An Experiment in Freshman Science Teaching. W. Bialek, Laboratories of Physics and Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 6:45 pm 2 Discovery, Innovation, and Policy in Human Health. S. Jackson, Rensselaer Polytechnic Institute, Troy, NY

Q Opening Night Reception Immediately Following Keynote Washington Convention Center All Meeting Participants and Exhibitors Are Welcome to Attend.

35 SATURDAY The American Society for Cell Biology 47th Annual Meeting December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org NOTES

36 The American Society for Cell Biology

Sunday December 2, 2007

47th Annual Meeting Washington, DC SUNDAY The American Society for Cell Biology 47th Annual Meeting December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

7:00 am –8:15 pm Exhibitor Showcases

7:30 am –5:00 pm Registration Open (East Registration)

7:30 am –9:00 pm Posters on Display (Halls A/B)

7:30 am–9:00 pm Career Center (Hall B)

8:00 am –9:30 am Symposium I (Ballrooms A/B/C) Membrane Dynamics

9:00 am –4:00 pm Exhibits Open (Halls A/B)

9:00 am –5:00 pm Education Resources/MAC Booth Opens (Grand Lobby)

9:30 am–10:30 am Morning Refreshment Break (Halls A/B)

9:45 am–10:15 am Alberts Award Presentation (Room 140) Catalyzing Changes in Undergraduate Science Education—Patricia J. Pukkila, University of North Carolina at Chapel Hill

10:30 am–12:00 Noon Symposium II (Ballrooms A/B/C) Architecture of Signaling Systems

12:00 Noon–2:00 pm MAC Awards Lunch (Room 143 A/B)

12:00 Noon–2:00 pm Postdoc Workshop (Room 140) Getting Out of the Box: Transitioning to a Career Outside of Academic Research

12:00 Noon–3:00 pm K–12 Science Education Partnership Lunch (Room 103A) (Tickets available at Event Ticket Counter) Biotechnology in the K–12 Classroom: Strategies for Teaching and Outreach—Julie Edmonds, Carnegie Academy for Science Education, Carnegie Institution of Washington

12:00 Noon–3:00 pm Poster Presentations (Halls A/B) Odd Boards: 12:00 Noon–1:30 pm; Even Boards: 1:30 pm–3:00 pm

12:30 pm–2:00 pm High School Program (Room 147) Getting In Shape: New Clues From the Fly Embryo—Jennifer Zallen, Sloan-Kettering Institute

2:00 pm–3:00 pm E. E. Just Lecture (Room 145) A Model System Approach to Uncover the Mechanisms of Animal Regeneration—Alejandro Sánchez Alvardo, University of Utah School of Medicine/HHMI

Daily Schedule—Sunday, December 2 Daily Schedule—Sunday, 2:30 pm–3:30 pm Afternoon Refreshment Break (Halls A/B)

2:30 pm–3:30 pm WICB Network Reception (Room 156)

3:40 pm–5:45 pm Minisymposium 1A (Room 147) Minisymposium 5 (Room 202) Cell Biology Working Group: The Nature of Cytoplasm Intermediate Filaments and Nuclear Lamins Minisymposium 1B (Room 151) Minisymposium 6 (Ballroom C) Cell Biology Working Group: The Cell Biology of Alzheimer’s Neuronal Cell Biology Disease Minisymposium 7 (Room 145) Minisymposium 2 (Room 146) Protein Folding Cell Cycle Minisymposium 8 (Ballroom B) Minisymposium 3 (Ballroom A) Signaling through Cell Adhesion Proteins Cytoskeletal Dynamics and Polarity Minisymposium 4 (Room 207) Host–Pathogens Interactions and Innate Immunity

6:00 pm–7:00 pm E. B. Wilson Medal Presentation and Address (Ballrooms A/B) Richard Hynes, Massachusetts Institute of Technology, and Zena Werb, University of California, San Francisco

6:30 pm–7:30 pm CBE—Life Sciences Education Reception (Room 156)

7:00 pm –8:00 pm Public Service Award Presentation (Room 147) Rep. Michael Castle (R-DE), U.S. House of Representatives

38 The American Society for Cell Biology 47th Annual Meeting SUNDAY December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

ASCB Annual Meeting Highlights—Sunday, December 2

Q Symposium I 8:00 am –9:30 am Ballrooms A/B/C Membrane Dynamics Pietro De Camilli, Yale University School of Medicine/HHMI, Jennifer Lippincott-Schwartz (Chair), The National Institute of Child Health and Human Development/NIH, Kit Pogliano, University of California, San Diego, Kai Simons, Max Planck Institute, Dresden

8:00 am Introduction 8:10 am 3 Remodeling Cellular Membranes during Bacillus subtilis Sporulation. K. Pogliano; University of California, San Diego, La Jolla, CA 8:35 am 4 Mechanisms of Membrane Deformation and Membrane Fission at Sites of Endocytosis. P. De Camilli; Department of Cell Biology, Howard Hughes Medical Institute, Kavli Institute For Neuroscience and CNNR, Yale University School of Medicine, New Haven, CT 9:00 am 5 Lipid Rafts in Membrane Traffi cking. K. Simons; Molecular Cell Biology and Genetics, Max Planck Institute, Dresden, Dresden, Germany

Q Morning Refreshment Break 9:30 am–10:30 am Halls A/B Supported by Nature Publishing Group

Q Bruce Alberts Award for Excellence in Science Education 9:45 am–10:15 am Room 140 Refreshments Served

Sponsored by the Education Committee Catalyzing Changes in Undergraduate Science Education

Patricia J. Pukkila University of North Carolina at Chapel Hill

9:45 am 6 Catalyzing Changes in Undergraduate Science Education. P. J. Pukkila,1 M. S. Arnold,2 D. H. Kiel 3; 1Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 2Offi ce for Undergraduate Research, University of North Carolina at Chapel Hill, Chapel Hill, NC, 3Institute for the Arts and Humanities, University of North Carolina at Chapel Hill, Chapel Hill, NC

39 SUNDAY The American Society for Cell Biology 47th Annual Meeting December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

Q Symposium II 10:30 am–12:00 Noon Ballrooms A/B/C Supported by The National Library of Medicine Architecture of Signaling Systems David Botstein (Chair), Princeton University, Richard M. Losick, Harvard University, Tobias Meyer, Stanford University School of Medicine, Pamela A. Silver, Harvard Medical School

10:30 am Introduction 10:40 am 7 Stochasticity and Cell Fate. R. M. Losick; The Biological Laboratories, Harvard University, Cambridge, MA 11:05 am 8 Design Principles for Connecting the Genome to the World. P. A. Silver, C. Brown, D. Drubin, E. Gee, D. Landgraf, I. Philips, C. Ajo-Franklin; Department of Systems Biology, Harvard Medical School, Boston, MA 11:30 am 9 STIM Proteins Function as Signaling Relays That Transmit Endoplasmic Reticulum Calcium Signals to the Plasma Membrane. T. Meyer, J. Liou, O. Brandman; Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford, CA

Q Minorities Affairs Committee (MAC) Awards Lunch (Preregistration Required) 12:00 Noon–2:00 pm Room 143 A/B

Q Postdoc Workshop 12:00 Noon–2:00 pm Room 140 (Ticket Required) Sponsored by the Subcommittee on Postdoctoral Training Getting Out of the Box: Transitioning to a Career Outside of Academic Research

Panelists representing teaching, science policy, government, science writing, industry, and patent law will briefl y discuss how they made the transition to careers outside of academia. This workshop, open to all early career scientists, will be followed by a question and answer and networking period. Includes box lunch.

Moderator: Melanie Styers, University of Alabama at Birmingham

Panelists: Kavita Berger, AAS Nicole C. Christacos, Quest Diagnostics Stacie Propst, Research!America Elisa Konieczko, Gannon University Deanna Heier, Science Writer, Clinical Options Alyssa Tippens, MedErgy Marketing, Inc. Representative from the U.S. Patent and Trademark Offi ce

$10 for all attendees; advance online registration; tickets also available at the Event Ticket Counter.

40 The American Society for Cell Biology 47th Annual Meeting SUNDAY December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

Q K–12 Science Education Partnership Lunch 12:00 Noon–3:00 pm Room 103A (Ticket Required) Sponsored by the Education Committee Biotechnology in the K–12 Classroom: Strategies for Teaching and Outreach

Julie Edmonds Carnegie Academy for Science Education Carnegie Institution of Washington

Students of all ages are fascinated with the exciting fi eld of biotechnology! Workshop presenters will engage participants in simple, hands-on activities that are useful for bringing biotechnology experiments into the K–12 classroom, and will lead discussions on successful models for initiating and sustaining biotechnology programs at local schools and colleges.

$10 for all attendees; advance online registration; tickets also available onsite at the Event Ticket Counter.

Q High School Program 12:30 pm–2:00 pm Room 147 Sponsored by the 2007 Local Arrangements Committee Getting In Shape: New Clues From the Fly Embryo

Jennifer Zallen Sloan-Kettering Institute

Ever wonder why you’re not an amorphous blob? And why people look like people and not like giraffes or whales? Every animal has a characteristic shape and form that we can easily recognize. These shapes are defi ned early on in the embryo, when the cells that make up the body reorganize to produce the correct three-dimensional structure. These cells use directional signals that act as microscopic traffi c signs, telling them where to go, where not to go, and when to stop. Single cells can travel on their own, but they can also caravan, moving in groups of cells that respond as a unit to directional cues. In this talk, we will explore the hidden world of the fruit fl y embryo by fi lming cells in motion to discover the signals that move the head away from the feet. The same types of processes set up the basic layout of the body plan in many animals, from fl ies to humans. After the presentation, students and teachers will tour exhibits from 2:00 pm–4:00 pm.

41 SUNDAY The American Society for Cell Biology 47th Annual Meeting December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

Q E. E. Just Lecture 2:00 pm–3:00 pm Room 145 A Model System Approach to Uncover the Mechanisms of Animal Regeneration

Alejandro Sánchez Alvarado University of Utah School of Medicine/HHMI 2:00 pm 10 A Model System Approach to Uncover the Mechanisms of Animal Regeneration. A. Sánchez Alvarado; Department of Neurobiology and Anatomy, Howard Hughes Medical Institute, University of Utah School of Medicine, Salt Lake City, UT

Q Afternoon Refreshment Break 2:30 pm–3:30 pm Halls A/B

Q WICB Network Reception 2:30 pm–3:30 pm Room 156 Refreshments served

Members of the ASCB Women in Cell Biology (WICB) Committee’s Network and people interested in learning more about the Net- work and the Committee’s activities—and meeting one another—are cordially invited to attend the WICB Network Reception.

Join the ASCB Public Policy Advocacy Team! Q Are you interested in public policy advocacy? Q Concerned about federal funding for biomedical research in America? Q Worried about intelligent design being taught in America’s science classrooms? Q Interested in educating your elected representatives about the importance of biomedical research? The ASCB Public Policy Committee Needs You! We need representatives in each of the 50 U.S. states to organize their colleagues in support of biomedical research.

We need you to organize and lead meetings with your representatives and write letters and Op/Eds to your local papers.

See www.ascb.org/publicpolicy/project50/index.cfm or email [email protected] for more information.

42 The American Society for Cell Biology 47th Annual Meeting SUNDAY December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

Q Minisymposium 1A 3:40 pm–5:45 pm Room 147 Cell Biology Working Group: Challenges in Cell Biology—The Nature of Cytoplasm Overall Moderator: R. Dyche Mullins, University of California, San Francisco Group Moderator: Wallace Marshall, University of California, San Francisco Presenters: Joseph Frankel, University of Iowa, Timothy Mitchison, Harvard Medical School, Rob Phillips, California Institute of Technology An educational experiment, this Minisymposium is designed to generate new ideas and stimulate new research. Two Working Groups of invited researchers with diverse expertise will discuss the current state of their fi elds, the mysteries that remain, and the directions in which they and others should be heading. Each Group will deal with an important area of cell biological research that might benefi t from new approaches. Rather than providing specialized talks on the most recent work from their own laboratories, speakers will present a general outline of their entire fi elds. They will discuss their fi eld’s history, current state of the art, and prospects for the future. The focus will be both on “how we know what we think we know” and “the questions that remain to be answered.” Think of this Minisymposium as a guidebook to help you navigate unfamiliar territory–your “Lonely Planet Guide” to a topic in Cell Biology that you may want to work on. Beginning with Franz Unger in the 1830s, biologists have marveled at the complex properties of cytoplasm. It appears, in some real sense, to be alive. Many fundamental processes of life arise from molecular interactions in this complex and immensely crowded mixture. What is the best way to think about cytoplasm? Can we describe its chemical and mechanical properties using well-understood models? Or does understanding the nature of cytoplasm require new physics and chemistry? What are the limits to what we can learn from studying cytoplasmic extracts? How much of cell fate is determined by inheritance of cytoplasmic, rather than nuclear, determinants? Cell biologists, biochemists, and physicists will discuss the nature of cytoplasm and the central questions that it poses today.

Q Minisymposium 1B 3:40 pm–5:45 pm Room 151 Cell Biology Working Group: Challenges in Cell Biology—The Cell Biology of Alzheimer’s Disease Overall Moderator: R. Dyche Mullins, University of California, San Francisco Group Moderator: Lennart Mucke, University of California, San Francisco Presenters: William Balch, Scripps Research Institute, Gopal Thinakaran, University of Chicago, Jonathan Weissman, University of California, San Francisco/HHMI An educational experiment, this Minisymposium is designed to generate new ideas and stimulate new research. Two Working Groups of invited researchers with diverse expertise will discuss the current state of their fi elds, the mysteries that remain, and the directions in which they and others should be heading. Each Group will deal with an important area of cell biological research that might benefi t from new approaches. Rather than providing specialized talks on the most recent work from their own laboratories, speakers will present a general outline of their entire fi elds. They will discuss their fi eld’s history, current state of the art, and prospects for the future. The focus will be both on “how we know what we think we know” and “the questions that remain to be answered.” Think of this Minisymposium as a guidebook to help you navigate unfamiliar territory–your “Lonely Planet Guide” to a topic in Cell Biology that you may want to work on. In 1906 Alois Alzheimer fi rst described the disease that now bears his name. He combined clinical observation with careful histopathol- ogy and identifi ed neurofi brillary tangles, lesions at the cellular level, as a potential causative agent. Over the next 100 years, our understand- ing of Alzheimer’s disease has progressed in lock step with our understanding of basic biochemistry and cell biology. Working out the details of amyloid formation, the interaction of amyloids with the cytoskeleton, intracellular traffi cking, and endosomal-lysosomal processing pathways have all contributed to our understanding of this complex disease. This Working Group will help us understand recent progress on the molecular basis of Alzheimer’s disease and highlight future directions in basic research and the search for therapeutics.

Q Minisymposium 2 3:40 pm–5:45 pm Room 146 Cell Cycle Co-Chairs: Michael Glotzer, The University of Chicago, and Sue L. Jaspersen, Stowers Institute for Medical Research 3:40 pm Introduction 3:45 pm 11 Interphase and Mitotic CDKs Follow Kinetically Distinct Paths to Activation in Human Cells. K. A. Merrick,1 S. Larochelle,1 C. Zhang,2 K. M. Shokat,2 R. P. Fisher1; 1Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY, 2Cellular and Molecular Pharmacology, University of California, San Francisco, CA

43 SUNDAY The American Society for Cell Biology 47th Annual Meeting December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

4:00 pm 12 *Single-Molecule Analysis Reveals the Distribution of Potential vs. Active DNA Replication Origins in Human Cells and Xenopus Egg Extracts. R. Lebofsky; Harvard Medical School, Boston, MA 4:15 pm 13 The Budding Yeast SUN Protein Mps3 Interacts with Sir4 and Functions as a Telomere Anchor at the Nuclear Periphery. J. M. Bupp, A. E. Martin, E. S. Erickson, S. L. Jaspersen; Stowers Institute for Medical Research, Kansas City, MO 4:30 pm 14 Intrafl agellar Transport Protein, IFT27, Is a Small Rab-like G Protein Involved in Ciliogenesis and in Control of the Cell Cycle. Z. Wang,1 D. Diener,1 J. M. Zones,2 J. Rosenbaum,1 U. James2; 1Molecular, Cellular, & Developmental Biology, Yale University, New Haven, CT, 2Plant Biology, Salk Institute for Biological Studies, La Jolla, CA 4:45 pm 15 The C-terminal Extension of hCenexin1 Is Critical for Proper Recruitment and Mitotic Functions of Mammalian Polo-like Kinase 1 (Plk1) at the Centrosomes. N. Soung,1 L. Yu,2 T. Veenstra,2 K. S. Lee1; 1Laboratory of Metabolism, National Cancer Institute/NIH, Bethesda, MD, 2Laboratory of Proteomics and Analytical Technologies, NCI–Frederick, Frederick, MD 5:00 pm 16 SUMO-2/3 Modifi cation and Binding Regulate the Association of CENP-E with Kinetochores and Progression through Mitosis. X. Zhang,1 J. Goeres,1 H. Zhang,1 T. J. Yen,2 A. C. G. Porter,3 M. J. Matunis1; 1Biochemistry and Molecular Biology, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD, 2Fox Chase Cancer Center, Philadelphia, PA, 3Gene Targeting Group, Hematology, Imperial College Faculty of Medicine, London, United Kingdom 5:15 pm 17 Anillin Is a Scaffold Protein That Links RhoA, Actin, and Myosin during Cytokinesis. A. J. Piekny, M. Glotzer; Molecular Genetics and Cell Biology, The University of Chicago, Chicago, IL 5:30 pm 18 Phospho-regulation of ase1p during Mitosis by the Kinase cdc2p and the Phosphatase cdc14p in Schizosaccharomyces pombe. C. Fu, I. Loiodice, P. Tran; Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA *MBC Paper of the Year

Q Minisymposium 3 3:40 pm–5:45 pm Ballroom A Cytoskeletal Dynamics and Polarity Co-Chairs: Ed Munro, Center for Cell Dynamics, University of Washington, and William Saxton, University of California, Santa Cruz 3:40 pm Introduction 3:45 pm 19 Reconstitution of a Microtubule Plus-End Tracking System In Vitro. P. Bieling,1 L. Laan,2 H. Schek,1 L. Munteanu,2 L. Sandblad,1 M. Dogterom,2 D. Brunner,1 T. Surrey1; 1European Molecular Biology Laboratory, Heidelberg, Germany, 2FOM Institute for Atomic and Molecular Physics (AMOLF), Amsterdam, The Netherlands 4:00 pm 20 STIM1 Is Transmembrane ER-resident Protein That Binds to EB1 and Tracks Growing Microtubule Plus Ends. S. M. Gouveia,1 I. Grigoriev,1 B. van der Vaart,1 J. Demmers,2 C. C. Hoogenraad,3 A. Akhmanova1; 1Cell Biology, Erasmus Medical Center, Rotterdam, The Netherlands, 2Biochemistry, Erasmus Medical Center, Rotterdam, The Netherlands, 3Neuroscience, Erasmus Medical Center, Rotterdam, The Netherlands 4:15 pm 21 Drebrin and EB3 Link Filamentous Actin and Dynamic Microtubules in Neuronal Growth Cones. S. Geraldo,1 M. Parsons,2 P. Gordon-Weeks1; 1Medical Research Council (MRC) Centre for Developmental Neurobiology, Kings College London, London, United Kingdom, 2Randal Division of Cell and Molecular Biophysics, Kings College London, London, United Kingdom 4:30 pm 22 Localized Translation of β-actin at Focal Adhesions and Affects Adhesion Formation and Dynamics. A. L. Wells, A. J. Rodriguez, W. Abou-Kheir, D. Cox, J. S. Condeelis, R. H. Singer; Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 4:45 pm 23 Yeast Formins Bni1 and Bnr1 Utilize Different Modes of Cortical Interaction during the Assembly of Actin Cables. S. Buttery, D. Pellman, S. Yoshida; Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 5:00 pm 24 Actin Dynamics Is Essential for Myosin-based Transport of Membrane Organelles. I. Semenova,1 A. Burakov,1 N. Berardone,1 T. Svitkina,2 V. Rodionov1; 1Cell Biology, University of Connecticut Health Center, Farmington, CT, 2Biology, University of Pennsylvania, Philadelphia, PA 5:15 pm 25 A Dynamic Actin Cytoskeleton Is Essential to Cytoplasmic Streaming during Drosophila Oogenesis. M. E. Quinlan,1 R. Loughlin,2 M. Breckenridge,3 E. Kerkhoff,4 R. Mullins1; 1Cell and Molecular Pharmacology, University of California, San Francisco (UCSF), San Francisco, CA, and Marine Biological Laboratory, Woods Hole, MA, 2Biophysics Graduate Group, University of California, Berkeley, Berkeley, CA, and Marine Biological Laboratory, Woods Hole, MA, 3Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH, and Marine Biological Laboratory, Woods Hole, MA, 4Bayerisches Genomforschungsnetzwerk, Institut für funktionelle Genomik, Universität Regensburg, Regensburg, Germany 5:30 pm 26 Cdc-42 and the Actomyosin Cytoskeleton Function within Positive and Negative Feedback Loops to Dynamically Stabilize Polarized Cortical Domains in the C. elegans Embryo. C. Schoff, H. Clark, A. Dawes, E. Munro; Center for Cell Dynamics, Friday Harbor, WA

44 The American Society for Cell Biology 47th Annual Meeting SUNDAY December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

Q Minisymposium 4 3:40 pm–5:45 pm Room 207 Supported by Genentech Host–Pathogens Interactions and Innate Immunity Co-Chairs: Joanne Engel, University of California, San Francisco, and Jean Greenberg, The University of Chicago 3:40 pm Introduction 3:45 pm 27 Pseudomonas aeruginosa Exotoxin T Inhibits Repair of Wounded Epithelium by Redundant and Failsafe Mechanisms. J. Engel, S. Shafi khani; University of California, San Francisco, San Francisco, CA 4:00 pm 28 An Atypical Receptor Kinase from Tomato Is Targeted by Xanthomonas campastris pathovar vesicotoria Effector XopN. X. Li, J. Roden, C. Aakre, B. Su, J. Kim, M. Mudgett; Biological Sciences, Stanford University, Stanford, CA 4:15 pm 29 Endocytosis of the Flagellin Receptor FLS2 in Plant Immunity. S. Robatzek, V. Göhre, T. Spallek, H. Häweker; Plant- Microbe Interactions, Max-Planck-Institute for Plant Breeding Research, Cologne, Germany 4:30 pm 30 A Small Molecule of Arabidopsis Petiole Exudates Confers Resistance to Bacterial Infection. H. Jung,1 T. Tschaplinsky,2 J. Greenberg1; 1Department of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, IL, 2Oakridge National Laboratory, Oakridge, TN 4:45 pm 31 An RNAi Screen Identifi es Profi lin and Other Host Cytoskeletal Proteins Required for Rickettsia Actin-based Motility. A. W. Serio, R. L. Jeng, C. M. Haglund, S. C. O. Reed, M. D. Welch; Molecular Cell Biology, University of California, Berkeley, Berkeley, CA 5:00 pm 32 Translocation of Mammalian Lipid Droplets into the Chlamydia trachomatis Parasitopherous Vacuole. J. Cochiaro,1 Y. Kumar,1 E. Fischer,2 T. Hackstad,2 R. H. Valdivia1; 1Molecular Genetics and Microbiology, Medical Center, Durham, NC, 2Host-Parasite Interactions Section, Rocky Mountain Laboratories, Hamilton, MT 5:15 pm 33 Histone Modifi cations Induced by a Family of Bacterial Toxins. M. A. Hamon,1 E. Batsché,1 B. Régnault,1 T. Tham,1 S. Seveau,2 C. Muchardt,1 P. Cossart1; 1Pasteur Institute, Paris, France, 2Ohio State University, Columbus, OH 5:30 pm 34 A Cellular Basis for Wolbachia Recruitment to the Host Germline. L. R. Serbus, W. T. Sullivan; Molecular, Cell, & Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA

Q Minisymposium 5 3:40 pm–5:45 pm Room 202 Intermediate Filaments and Nuclear Lamins Co-Chairs: Pamela K. Geyer, University of Iowa, and Birgit Lane, IMB Singapore and University of Dundee 3:40 pm Introduction 3:45 pm 35 Laminopathic Mutations Interfere with the Assembly, Localization, and Dynamics of Nuclear Lamin in C. elegans. Y. Gruenbaum,1 N. Weisel,1 A. Mattout,1 K. Ben-Harush,2 H. Herrmann,3 U. Aebi,4 O. Medalia2; 1Genetics, Hebrew University of Jerusalem, Jerusalem, Israel, 2Life Sciences, The Ben Gurion University, Beer Sheva, Israel, 3Cell Biology, DKFZ, Heidelberg, Germany, 4M. E. Mueller Institute, Biozentrum, University of Basel, Basel, Switzerland 4:00 pm 36 Changes in the Organization and Regulation of Chromatin in Progeria, an Early Onset Premature Aging Disease. K. S. Pfl eghaar,1 T. Shimi,1 I. Solovei,2 M. Cremer,2 T. Cremer,2 R. D. Goldman1; 1Cell and Molecular Biology, Northwestern University Medical School, Chicago, IL, 2Biology II, Anthropology and Human Genetics, Ludwig Maximilians University, Grosshadern, Germany 4:15 pm 37 Lamin A-dependent Misregulation of Adult Stem Cells Associated with Accelerated Aging. P. Scaffi di, T. Misteli; National Cancer Institute/NIH, Bethesda, MD 4:30 pm 38 Disease-associated Lamin A/C Mutations Disrupt Cell Polarity with Phenotypes That Segregate by Disease. E. S. Folker, C. Ostlund, H. J. Worman, G. G. Gundersen; Anatomy and Cell Biology, Columbia University, New York, NY 4:45 pm 39 Increased Neurogenesis and Astrogenesis from Neural Progenitor Cells Grafted in the Hippocampus of GFAP-/-Vim-/- mice. M. Pekny, A. Widestrand, J. Faijerson, P. L. P. Smith, L. Li, C. Sihlbom, P. S. Eriksson, U. Wilhelmsson; Department of Clinical Neuroscience, Sahlgrenska Academy at Göteborg University, Göteborg, Sweden 5:00 pm 40 Altered Signaling but No Cell Fragility in Mice Lacking All Type II Keratin Genes. P. Vijayaraj,1 C. Kroeger,1 U. Reuter,1 D. Hartmann,2 D. Simmons,3 T. Magin 1; 1Institute for Physiological Chemistry, Bonn, Germany, 2Institute for Anatomy, Bonn, Germany, 3Department of Comparative Biology and Experimental Medicine, University of Calgary, Calgary, AB, Canada 5:15 pm 41 A New Functional Role for Keratin 18 Glycosylation in Protection from Injury in Epithelial Tissues. N. Ku, D. Toivola, P. Strnad, M. Omary; Division of Gastroenterology and Hepatology, Stanford University Medical School, and VA Palo Alto Health Care System, Stanford, CA

45 SUNDAY The American Society for Cell Biology 47th Annual Meeting December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

5:30 pm 42 Reprogramming of Keratin Biosynthesis by the Natural Product Sulforaphane Restores Skin Integrity in Epidermolysis Bullosa Simplex. P. A. Coulombe,1 M. L. Kerns,1 D. DePianto,1 A. T. Dinkova-Kostova,2 P. Talalay2; 1Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD, 2Pharmacology, Johns Hopkins University School of Medicine, Baltimore, MD

Q Minisymposium 6 3:40 pm–5:45 pm Ballroom C Neuronal Cell Biology Co-Chairs: Michael D. Ehlers, Duke University Medical Center/HHMI, and Franck Polleux, University of North Carolina at Chapel Hill 3:40 pm Introduction 3:45 pm 43 Formin Binding Protein 2 (FNBP2) Regulates Neuronal Migration and Morphology through Its F-BAR Domain. S. Guerrier,1 A. Shutes,2 R. Doughman,3 K. Burridge,3 C. J. Der,2 F. Polleux1; 1Pharmacology and The Neuroscience Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 2Lineberger Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 3Cell and Developmental Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 4:00 pm 44 MARK2/Par1: Linking the Polarity Pathway to -dependent Centosomal Motility in Migrating Cortical Neurons. O. Reiner,1 T. Sapir,1 S. Sapoznik,1 A. Gorelik,1 T. Levy,1 T. Timm,2 E. Mandelkow2; 1Weizmann Institute, Rehovot, Israel, 2Max-Planck-Unit for Structural Molecular Biology, Hamburg, Germany 4:15 pm 45 The Arf1 GAP Centaurin Gamma-2/AGAP1 Modulates Neuronal Differentiation. J. L. Larimore,1 C. Chapleau,1 I. Rolle,2 C. Moore,1 S. Worth,1 Z. Nie,3 P. Randazzo,4 L. Pozzo-Miller,1 A. Theibert1; 1Neurobiology, University of Alabama at Birmingham, Birmingham, AL, 2Oakwood University, Huntsville, AL, 3Pathology, Medical College of Georgia, Augusta, GA, 4National Cancer Institute/NIH, Bethesda, MD 4:30 pm 46 The Function and Regulation of Dendritic Golgi Outposts. B. Ye, Y. Zhang, L. Y. Jan, Y. Jan; Physiology, University of California, San Francisco/HHMI, San Francisco, CA 4:45 pm 47 UNC-6/netrin, UNC-5 and a Cyclin Target Presynaptic Components to Axons in C. elegans. K. Shen,1 V. Y. N. Poon2; 1Biological Sciences, Stanford University, Stanford, CA, 2Neuroscience Program, Stanford University, Stanford, CA 5:00 pm 48 Microtubule Plus-End Binding Protein EB3 Regulates Dendritic Spine Morphogenesis. J. Jaworski,1 B. Dortland,2 S. Gouveia,3 P. Wulf,2 A. Akhmanova,3 C. C. Hoogenraad2; 1International Institute of Molecular and Cell Biology, Warsaw, Poland, 2Neuroscience, Erasmus Medical Center, Rotterdam, The Netherlands, 3Cell Biology, Erasmus Medical Center, Rotterdam, The Netherlands 5:15 pm 49 Positioning Endocytic Zones and AMPA Receptor Cycling in Dendritic Spines. J. Lu,1 T. D. Helton,1 T. A. Blanpied,1 B. Racz,2 T. M. Newpher,1 R. J. Weinberg,2 M. D. Ehlers1,3; 1Neurobiology, Duke University Medical Center, Durham, NC, 2Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, NC, 3Howard Hughes Medical Institute, Durham, NC 5:30 pm 50 Signals and Adaptors Controlling the Endocytosis and Sorting of Non-conventional NMDA Receptors. E. Saint-Michel, R. Martínez-Turrillas, I. Pérez-Otaño; Neuroscience, Center for Applied Medical Research, Pamplona, Spain

Q Minisymposium 7 3:40 pm–5:45 pm Room 145 Protein Folding Co-Chairs: Elizabeth Craig, University of Wisconsin–Madison, and Suzannah L. Rutherford, Fred Hutchinson Cancer Research Center 3:40 pm Introduction 3:45 pm 51 Peptide Affi nity and Hsp40 J-domain Interaction Differentially Affect Yeast BiP Function. S. S. Vembar,1 S. Nishikawa,2 L. M. Hendershot,3 J. L. Brodsky1; 1Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA, 2Department of Chemistry, Graduate School of Science, Nagoya University, Chikusaku, Nagoya, Japan, 3Department of Tumor Cell Biology, St. Jude Children’s Research Hospital, Memphis, TN

46 The American Society for Cell Biology 47th Annual Meeting SUNDAY December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

4:00 pm 52 Translocon-mediated Head-First Insertion and Rotation of a Signal Anchor during Cotranslational Integration. P. K. Devaraneni,1 B. Conti,1 A. E. Johnson,2,3,4 W. R. Skach1; 1Biochemistry & Molecular Biology, Oregon Health & Sciences University, Portland, OR, 2Molecular and Cellular Medicine, Texas A&M University System Health Science Center, College Station, TX, 3Chemistry, Texas A&M University, College Station, TX, 4Biochemistry & Biophysics, Texas A&M University, College Station, TX 4:15 pm 53 Network of General and Specialty J-protein Chaperones of the Yeast Cytosol. C. Sahi, E. Craig; Department of Biochemistry, University of Wisconsin, Madison, Madison, WI 4:30 pm 54 The Substrate-binding Domain of Ydj1 Has Distinct Functions in Promoting Stability and Activity of the Hsp90-dependent Kinase Ste11. G. Flom, M. K. Lemieszek, J. L. Johnson; Microbiology, Molecular Biology, and Biochemistry, University of Idaho, Moscow, ID 4:45 pm 55 Prion Dynamics and Protein-Only Inheritance. T. R. Serio; Brown University, Providence, RI 5:00 pm 56 Chaperone Networks That Infl uence Protein Misfolding and Aggregation in C. elegans. C. Voisine, M. Schieber, S. McFall, K. Orton, R. I. Morimoto; Northwestern University, Evanston, IL 5:15 pm 57 Uncovering the Essential Cellular Substrates and Functions of Hsp90 with Genome-wide Screens. A. J. McClellan,1 Y. Xia,2 A. M. Deutschbauer,3 R. W. Davis,3 M. Gerstein,4 J. Frydman5; 1Cell Biology, Bennington College, Bennington, VT, 2Chemistry, Boston University, Boston, MA, 3Biochemistry, Stanford University, Stanford, CA, 4Molecular Biophysics & Biochemistry, Yale University, New Haven, CT, 5Biological Sciences, Stanford University, Stanford, CA 5:30 pm 58 Protein Mis-folding, Cellular Consequences and Beyond. S. Rutherford; Division of Basic Science, Fred Hutchinson Cancer Research Center, Seattle, WA

Q Minisymposium 8 3:40 pm–5:45 pm Ballroom B

Signaling through Cell Adhesion Proteins Co-Chairs: David A. Calderwood, Yale University School of Medicine, and Masatoshi Takeichi, RIKEN Center for Developmental Biology 3:40 pm Introduction 3:45 pm 59 Regulation of Filamin-Integrin Interactions. Y. Lad,1 T. Kiema,2 P. Jiang,3 K. L. Wegener,3 I. D. Campbell,3 J. Ylänne,4 D. A. Calderwood1; 1Department of Pharmacology, Yale University School of Medicine, New Haven, CT, 2Department of Biochemistry and Biocenter Oulu, University of Oulu, Oulu, Finland, 3Department of Biochemistry, University of Oxford, Oxford, United Kingdom, 4Department of Biological and Environmental Science, University of Jyväskylä, Jyväskylä, Finland 4:00 pm 60 Zasp, a Novel Regulator of Integrin Inside-out Activation? K. Jani, F. Schöck; Department of Biology, McGill University, Montreal, PQ, Canada 4:15 pm 61 Tension Increases the Strength of α5β1 Integrin-Fibronectin Bonds by Inducing Engagement of the Synergy Site in FnIII-9. D. Boettiger, M. Chan, J. Friedland, M. Lee; University of Pennsylvania, Philadelphia, PA 4:30 pm 62 Lamellipodium Extension and Membrane Ruffl e Formation Require Different SNARE-mediated Traffi cking Pathways. M. Skalski, Y. Qing, D. W. Myers, M. G. Coppolino; Department of Molecular and Cellular Biology, University of Guelph, Guelph, ON, Canada 4:45 pm 63 VEGF Controls Endothelial Cell Permeability by the Endocytosis of VE-cadherin. J. Gavard, J. Gutkind; Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research/NIH, Bethesda, MD 5:00 pm 64 The Role of Scribble in Regulating Epithelial Cell Adhesion. M. Lohia, I. G. Macara; Microbiology, University of Virginia, Charlottesville, VA 5:15 pm 65 Structure Elements Necessary for Oligomerization, Traffi cking, and Cell Sorting Function of Paraxial Protocadherin. X. Chen, C. Molino, L. Liu, B. Gumbiner; Department of Cell Biology, University of Virginia, Charlottesville, VA 5:30 pm 66 Mammalian Fat4 Regulates the Apical Domain Organization in Polarized Epithelial Cells. T. Tanoue,1 T. Ishiuchi,2 M. Takeichi1; 1RIKEN Center for Developmental Biology, Chuo-ku, Kobe, Japan, 2Graduate School of Biostudies, Kyoto University, Sakyo-ku, Kyoto, Japan

47 SUNDAY The American Society for Cell Biology 47th Annual Meeting December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

Q E. B. Wilson Medal Presentation and Address 6:00 pm–7:00 pm Ballrooms A/B Donna Coveney

Richard Hynes Zena Werb Massachusetts Institute University of California, of Technology/HHMI San Francisco

6:00 pm 67 Cell Adhesion: The Essence of Being Metazoan. R. O. Hynes; Massachusetts Institute of Technology/HHMI, Cambridge, MA 68 The Wonderful World Outside the Cell. Z. Werb; Department of Anatomy, University of California, San Francisco, San Francisco, CA

Q CBE—Life Sciences Education Reception 6:30 pm–7:30 pm Room 156

Join an informal session with Editorial Board members about how to publish a paper in the education journal, CBE—Life Sciences Education, featuring assessment as the key to a successful submission.

In addition, several editors from the education journal will be present at the Education Poster Session on Tuesday, December 4, 12:00 Noon–3:00 pm to consult with potential authors.

Q Public Service Award Presentation 7:00 pm–8:00 pm Room 147 Refreshments Served

The Honorable Michael Castle (R-DE) U.S. House of Representatives

Congressman Castle is being recognized for his support of biomedical research, his strong leadership on behalf of stem cell research, and his commitment to the National Institutes of Health.

48 The American Society for Cell Biology 47th Annual Meeting SUNDAY December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

EXHIBITOR SHOWCASES WASHINGTON CONVENTION CENTER

Cell Signaling Technology® 7:00 am–8:00 am, Room 201 Cell Signaling Technology® 8:00 am–9:00 am, Room 201 Quantifi cation of Cellular Signaling Using Activation State-Specifi c Novel Reagents for the Analysis of Cellular Signaling in Cells and Tissues Antibodies and Automated Plate-Based Fluorescent Analysis by Immunofl uorescence and Chromogenic Immunohistochemistry Platforms Level: Intermediate Level: Intermediate Presenter: Randy Wetzel Presenter: Randy Wetzel Cell Signaling Technology® Cell Signaling Technology® 3 Trask Lane 3 Trask Lane Danvers, MA 01923 Danvers, MA 01923 Phone: (978) 867-2300 Phone: (978) 867-2300 Fax: (978) 867-2400 Fax: (978) 867-2400 www.cellsignal.com www.cellsignal.com Activation state-specifi c antibodies (e.g., phospho-specifi c) can be used Plate-based analyses require robust and specifi c antibody-based tools. Cell with fl uorescence or chromogenic imaging to examine the cellular signaling Signaling Technology has a large number of antibodies that have been rig- underlying biological processes. These antibodies can be used to identify orously tested in plate-based immunofl uorescent fi xed cell assays. We will aberrant disease-related signaling, or to examine treatment-induced differ- demonstrate how these signaling antibodies (e.g., phospho-specifi c) can be ences in protein activity, expression level, or subcellular localization. Cell used to investigate disease-related signaling, or to examine the effect of drugs Signaling Technology has also developed antibodies that specifi cally detect or treatments on cells grown in multi-well plates. The antibodies can be used genetic abnormalities, phosphorylation motifs (phospho-tyrosine, Akt individually to monitor the expression/activity of a specifi c protein/pathway. substrate, MAPK substrate, etc.), and other protein modifi cations such as They can also be arranged in large arrays to profi le signaling across many acetylation, ubiquitinization, and methylation. Cell Signaling Technology different pathways (PI3K/Akt, RAS/MAPK, JAK/STAT, SMADs, NF-κB, has a large number of IF and IHC validated antibodies that have under- etc.), or to examine biological processes such as proliferation, apoptosis, gone rigorous testing on cells and frozen or paraffi n tissue sections using cell cycle, DNA damage, stress, infl ammation, and metabolism. We will confocal immunofl uorescence, chromogenic immunohistochemistry, fl ow describe treatment and staining protocols and discuss antibody validation cytometry, and plate-based fl uorescence assays. The presenter will discuss for plate-based immunofl uorescent assays. treatment and staining protocols and be available for one-on-one discus- sions to provide advice or technical assistance. Invitrogen 7:00 am–9:00 am, Room 206 Imaging of Cellular Junctions Invitrogen 9:15 am–11:15 am, Room 201 Level: Introductory 3-D Cell Culture Tools for Biologically Relevant In Vitro Systems Presenter: Jarkko Huuskonen Level: Introductory Invitrogen Presenter: Mark Powers 1600 Faraday Avenue Invitrogen Carlsbad, CA 92008 1600 Faraday Avenue Phone: (800) 955-6288 Carlsbad, CA 92008 Fax: (760) 603-7229 Phone: (800) 955-6288 www.invitrogen.com Fax: (760) 603-7229 www.invitrogen.com There are fi ve main types of cellular junctions: gap junctions, tight junc- tions, adherens junctions, desmosomes, and hemidesmosomes. Cell Three-dimensional cell culture methods provide an approach to creating in junctions play a key role in regulating small molecule traffi cking between vitro environments with enhanced recapitulation of tissue like structures. cells, organization of cells into tissues, and the adhesion of cells to each Compared with traditional techniques, these culture systems offer the other and to extracellular matrix. In addition to playing a major role in potential of cellular function and response with improved physiological normal physiology, dysfunctional junctions have been implicated in several relevance, while offering a more consistent, predictive, and fl exible experi- pathophysiological conditions, including cancer. Invitrogen offers a highly mental system for research traditionally in in vivo and ex vivo systems. This characterized panel of both poly- and monoclonal antibodies to a variety of presentation will focus on this shift in the approach to cell culture and new junctional components, such as connexins (main structural components of products that address this growing demand. gap junctions), claudins (tight junction components), catenins (located in adherens junction), and accessory molecules such as zona occludens (ZO) proteins and junctional signaling molecules. These antibodies have been validated for imaging applications.

49 SUNDAY The American Society for Cell Biology 47th Annual Meeting December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

EXHIBITOR SHOWCASES WASHINGTON CONVENTION CENTER

Thermo Fisher Scientifi c 9:15 am–11:15 am Room 206 Nalgene and Nunc Brand Products 11:30 am–1:30 pm, Room 201 Thermo Scientifi c SearchLight® Plate-Based Arrays for Multiplex The Surface Matters for Cell Culture Protein Profi ling Level: Intermediate Level: Intermediate Presenter: Joe Granchelli Presenter: Scott Van Arsdell Nalgene and Nunc Brand Products Thermo Fisher Scientifi c 75 Panorama Creek Drive Pierce Products Rochester, NY 14625 PO Box 117 Phone: (585) 586-8800 Rockford, IL 61105 Fax: (585) 586-3294 Phone: (800) 874-3723 www.Nalgenunc.com Fax: (815) 968-7316 www.thermo.com/pierce Researchers are aware of the need to optimize reaction conditions with standardized reagents, but the vessel in which the reaction takes place par- Thermo Scientifi c SearchLight Protein Arrays are multiplex, plate-based ticipates in the reaction to infl uence the fi nal outcome as well. In culture of sandwich ELISA assays for the quantitative measurement of 2 to 24 proteins adherent cells the surface is just as important as the media. Components of per well. The original SearchLight platform utilizes a chemiluminescent media must bind to surfaces in the right orientation and concentration to substrate and cooled CCD imager to generate highly sensitive data for up to be able to facilitate physical attachment of cells. Adhesion molecules trans- 16 proteins per well. The infrared platform offers higher density arrays with duce the attachment signal across the plasma membrane, driving changes a broad dynamic range. This seminar will review the SearchLight Technol- in physiology that can affect the performance of subsequent assays. This ogy, the array confi gurations available, and the instrumentation and array Showcase will discuss examples where surfaces interact with cells as well as software utilized to generate accurate, reproducible results. SearchLight Ar- strategies that are employed to modify surfaces to improve adherent cell rays for cytokines, chemokines, MMPs, angiogenesis factors, neurotrophic culture and other molecular binding assays. factors, kinases, and various disease biomarkers (obesity, diabetes, cardiac, neurological, infl ammation, cancer) have been developed. Performance BD Biosciences 12:30 pm–1:30 pm, Room 206 data exhibiting specifi city, accuracy, and reproducibility of the arrays will Analyzing Signaling Networks of Various Stem Cell Populations Using be presented. The SearchLight Testing Service will also be reviewed. Flow Cytometry Level: Intermediate BD Biosciences 11:30 am–12:30 pm, Room 206 Presenter: Robert Balderas Making the Most of Your Cell-based Assays: An Exploration of BD Biosciences Innovative Tools and Technologies 10975 Torreyana Road Level: Introductory San Diego, CA 92121 Presenter: Phil Vanek Phone: (858) 812-8940 BD Biosciences Fax: (858) 812-8995 15010 Broschart Road www.bdbiosciences.com Rockville, MD 20850 Phone: (301) 340-7320 x22 Intracellular assays that measure signal transduction have been limited by Fax: (301) 340-9775 the inability to identify subsets of cells within complex populations on the www.bdbiosciences.com basis of post-translational modifi cations. We demonstrate the ability to simultaneously monitor active protein states via phospho-epitope recogni- Cell-based assays are rapidly becoming a mainstay in pharmaceutical and tion in cell subpopulations by multiparameter fl ow-cytometric analysis. life-science research laboratories. To effectively understand the complex Multi-dimensional assessment of phosphorylation status, in combina- workings of the cell requires a suite of tools to prepare and analyze a wide tion with other established fl ow cytometric assays (i.e., surface markers, variety of cell types. Tools such as fl ow sorting, imaging cytometry, activation cytokines, apoptosis, and cell cycle), provides functional assessment on state antibodies, and relevant cellular environments are essential to the mod- a single cell level. We and our collaborators are currently investigating ern cell biologist. Collectively these tools enable a broad array of research the use of this technique in monitoring disease progression and stem cell applications including angiogenesis, neurite outgrowth, cell signaling, cell differentiation. invasion, and cell signaling, among others. This presentation will introduce a comprehensive suite of innovative tools and discuss novel applications being developed using BD Biosciences tools and technologies.

50 The American Society for Cell Biology 47th Annual Meeting SUNDAY December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

EXHIBITOR SHOWCASES WASHINGTON CONVENTION CENTER

EMD Biochemicals 1:45 pm–2:45 pm, Room 206 RNAi and cellular processes. We will discuss how RNAi, including Cell-Based Assays: Indispensable Tools for Drug Discovery and Basic siRNA transfection reagents, siRNA labeling and tracking reagents, Research and a miRNA expression profi ling system, may be used for functional Level: Intermediate analysis, pathway elucidation, target validation and creation of cell- Presenter: Lothar Goretzki based HTS assays. EMD Chemicals, Inc. 10394 Pacifi c Center Court EMD Biochemicals 2:45 pm–3:45 pm, Room 206 San Diego, CA 92121 Phosphorylation and Mitochondrial Dependent Death Phone: (858) 450-5611 Level: Intermediate Fax: (858) 453-3552 Presenter: Michael J. Boyer www.emdbiosciences.com EMD Chemicals, Inc. 10394 Pacifi c Center Court Cell-based assays entail the study of proteins and genes in the context San Diego, CA 92121 of the cellular environment and the identifi cation of drug effects on Phone: (858) 450-5611 whole cells. These assays enable scientists to assess various cellular Fax: (858) 453-3552 processes under more physiological conditions, and thus are superior www.emdbiosciences.com to traditional in vitro assays. We have developed convenient and sensitive assays to study cell adhesion, cell migration, cell invasion, The study of apoptosis has gained signifi cant importance in human disease and cell proliferation for use with many different types of cells. The and its clinical management. All multicellular organisms are faced with assays allow convenient dose-response measurements. The seminar the constant challenge of balancing cell growth with cell death to regulate will give a brief overview of assay principle and application of these homeostasis. Once a cell is committed to apoptosis, a series of highly coor- assays. The presentation also outlines which research areas and proj- dinated events result in the cell’s ultimate demise. Most apoptosis occurs via ects are most applicable for individual cell-based assays and provides the mitochondrial pathway, whereby the mitochondrial outer membrane an outlook of future developments and trends in pertinent areas of becomes permeabilized (MOMP), and proteins from the intermembrane cellular analysis. space diffuse into the cytosol. These events are characterized by a number of biochemical and morphological changes, involving members of the Mirus Bio Corporation 1:45 pm–3:45 pm, Room 201 Bcl-2 family of proteins, as well as additional mitochondrial proteins. This Applications of RNAi in the Study of Cell Biology seminar will focus on novel tools and assays for detecting and measuring Level: Advanced apoptosis including changes in subcellular localization and activation of Presenter: Robert Brazas apoptotic proteins, as well as assessment of specifi c mitochondrial protein Mirus Bio Corporation phosphorylations. 505 South Rosa Road Madison, WI 53719 FEI Company 4:00 pm–6:00 pm, Room 201 Phone: (608) 441-2852 Electron Microscopy Solutions for 2D and 3D Imaging in Cell Biology Fax: (608) 441-2849 Applications www.mirusbio.com Level: Intermediate Presenter: Wim Voorhout Applications of RNA interference (RNAi) have become indispensable FEI Company for the evaluation of gene function in mammalian cells. Small inter- 5350 NE Dawson Creek Drive fering RNAs (siRNAs) and microRNAs (miRNAs) are both involved Hillsboro, OR 97124 in RNAi pathways and are capable of inhibiting expression of target Phone: (503) 726-7500 mRNAs by either promoting mRNA cleavage or inhibiting translation, Fax: (503) 726-7509 depending on the degree of complementarity to the target sequence. www.fei.com Mirus Bio has developed specialized methodologies to facilitate the study and use of RNAi. Specifi c gene knock-down can be initiated by Studying the 3D architecture of cells requires the creation of image data with introducing target-specifi c siRNAs or siRNA-expression constructs into suffi cient detail at all orientations. Today’s requirements for greater resolu- cells by transfection. MicroRNAs are highly conserved endogenous tion have driven demand for novel ways to obtain more detailed information small RNAs that are distinct from siRNAs. They are believed to be from tissue, cells, cell organelles, viruses, protein complexes, and individual essential for cell proliferation and differentiation, with abnormalities proteins. FEI will compare traditional microtome and TEM imaging to in miRNA activity contributing to the pathogenesis of human diseases new techniques for 3D imaging: FEI’s Slice&View™ application, combin- including cancer. Microarray analysis of miRNA expression profi les ing focused ion beam (FIB) slicing with successive in-situ high-resolution is a powerful and commonly used methodology to assess the relative SEM imaging of cryo-prepared samples, and Xplore3D™, a software suite levels of individual miRNAs in specifi c tissues and study their role in that seamlessly integrates all the steps in TEM electron tomography, from

51 SUNDAY The American Society for Cell Biology 47th Annual Meeting December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

EXHIBITOR SHOWCASES WASHINGTON CONVENTION CENTER automated data acquisition to visualization of the reconstructed volume. with the traditional BrdU method. The assay employs the incorporation FEI will present practical applications to illustrate both techniques, as of an alkyne modifi ed nucleoside, EdU (5-ethynyl-2´-deoxyuridine), into well as provide the opportunity to discuss new developments in cryo-EM the DNA and detection with click chemistry based reaction with an azide equipment and applications. modifi ed fl uorescent molecule. Sensitivity of S-phase detection in control and cell cycle blocked pro- Molecular Devices 4:00 pm–6:00 pm, Room 206 liferating cultured cells, including A549, HeLa, and Jurkats, are shown Advances in Multi-dimensional Imaging and High-speed Confocal multiplexed with antibody labeling. EdU detected S-phase fraction in Microscopy two animal models will also be presented. Sensitivity of S-phase detection Level: Introductory in control and cell cycle blocked proliferating cultured cells, including Presenter: Christian Kier A549, HeLa, and Jurkats, are shown multiplexed with antibody labeling. Molecular Devices In animals, EdU detection of S-phase fraction in estrogen treated rat model 402 Boot Road and labeled stem cell derived cells in the adult bird neurogenesis model will Downingtown, PA 19335 also be presented. Phone: (484) 693-3816 With cultured cells, 5 minute pulses of BrdU or EdU produced detect- www.moleculardevices.com able signals in adherent cells; however, denaturation requirements for the BrdU protocol drastically reduced its compatibility in multiplex labeling Molecular Devices, in partnership with VisiTech International Ltd., has with antibody probes. In fl ow cytometry longer wavelength fl uorophores released the MetaMorph ICS®, a turnkey confocal microscope optimized used in EdU labeling gave specifi c advantage in signal to background for high-speed acquisition and analysis. At its core is the VT-Infi nity3™ 2D ratios. confocal array scanner coupled with MetaMorph®, the industry standard With hormone induced proliferation in rat mammary epithelial tissue, microscope automation and image analysis package. This unique combi- we found EdU labeling and detection gave equivalent sensitivity to BrdU nation enables users to explore the area of live cell and functional imaging but was simpler and easier to use, while in the avian brain model EdU without the limitations inherent in other high-speed imaging technologies. labeled adult born neurons could be visualized using a shortened protocol A description and introduction to this system will be presented along with of 25 minutes and resulted in clear strong signals while the most rapid BrdU examples of its practical application. visualization required overnight treatment or 2 hours if high background was acceptable. Invitrogen 6:15 pm–8:15 pm, Room 206 Evaluation of Click-iT™ EdU Cell Proliferation Assays in Tissue and Nikon Instruments 6:15 pm–8:15 pm, Room 201 Cultured Cells Using Fluorescent Microscopy, High Content Screen- Understanding the Cell Migration Engine Using High-Resolution ing, and Flow Cytometry Quantitative Light Microscopy Level: Intermediate Level: Intermediate Presenter: Scott Clarke Presenter: Clare M. Waterman Invitrogen Nikon Instruments Inc. 1600 Faraday Avenue 1300 Walt Whitman Road Carlsbad, CA 92008 Melville, NY 11747 Phone: (800) 955-6288 Phone: (631) 547-8500 Fax: (760) 603-7229 Fax: (631) 547-8652 www.invitrogen.com www.nikoninstruments.com

Evaluation of a novel method for determining S-phase percentage by fl ow The lecture will be followed by these exciting introductions: Nikon’s new cytometry, imaging, or high content screening (HCS) will be presented. Inverted microscope series Ti—at the center of your live cell imaging dis- The labeling strategy using Click-iT™ EdU cell proliferation assays from coveries, defi ning infi nite possibilities; Nikon’ new A1 Confocal series, the Molecular Probes® demonstrates measurements and changes in cell new A1 FlexScan, bringing imaging to life—“VAAS ist Das” explained; and proliferation in both cultured cells and in animal models and is compared BioStation—Nikon’s new imaging solutions for your cell’s environment.

52 The American Society for Cell Biology 47th Annual Meeting SUNDAY December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

Poster Session I Halls A/B

Poster Set Up Saturday 6:00 pm–6:30 pm

Posters Displayed Saturday 7:00 pm–9:00 pm Sunday 7:30 am–5:30 pm

Author Presentation Odd Boards 12 Noon–1:30 pm Even Boards 1:30 pm–3:00 pm

Poster Tear Down Sunday 5:30 pm–6:00 pm

Board Numbers Session Titles Board Numbers Session Titles B1-24 Epithelia B315-331 Kinesin I B25-39 New and Emerging Technologies for B332-356 Cell Motility – Regulation I Cell Biology I B357-380 Cytoskeletal Organization I B40-53 Chromatin and B381-401 Cilia and Flagella I B55-69 Ribonucleoproteins and RNA B403-424 Actin Dynamics and Assembly I Localization B425-436 Dynein I B70-79 Gene Structure and Expression B438-461 Metabolic Disease B80-95 Mechanisms of Nuclear B462-480 Host-Non-Bacterial Pathogen Interactions B97-118 Endoplasmic Reticulum B481-495 Cell Biology of the Immune System I B119-132 Signal Transduction in Development I B496-511 Other Diseases I B133-153 Stem Cells B512-534 Cancer I B154-159 Invertebrate Development B536-551 Signal Transduction I B160-182 Stem Cell Biology B552-568 Cell Cycle Controls I B183-191 Membrane Fusion B569-590 Mitosis and Meiosis I B192-196 Caveolae B591-606 Cytokinesis I B197-208 : Plasma Membrane Events B607-627 Apoptosis B209-225 Membrane Receptors B628-631 Cytokines B226-240 Endocytosis I B632-656 Intracellular Movement B241-264 Extracellular Matrix and Cell Behavior B657-680 Muscle: Biochemistry and Cell Biology B265-284 Cell-Cell Adherens Junctions B681-705 Microtubule-associated Proteins B285-305 Cadherins B707-731 Neurotransmitters, Peptides and Receptors B306-313 Extracellular Matrix and Morphogenesis

Annual Meeting Poster Presentation Guidelines • Presenters should ensure their posters are placed on the appropriate poster board for the duration of their as- signed poster sessions (the full 24-hour period). In cases of emergency, poster presenters who are unable to present should contact the ASCB at [email protected] to withdraw their abstract(s) before the Annual Meeting. In the case of withdrawn posters, a “WITHDRAWN” sign will be posted, along with the author’s contact information, on the poster board. • Poster presenters should stand at their poster locations during the appropriate 90-minute time slot—12:00 Noon–1:30 pm, or 1:30 pm–3:00 pm. (The specifi c information is included in the original poster notifi cation emails sent in September.) If presenters have to leave early, they should post a note on their boards stating when they will be available to answer attendee questions. • Cameras/Photography: Cameras and all other recording devices are strictly prohibited in all session rooms, on the Exhibit fl oor, and in all poster and oral presentation sessions.

53 SUNDAY The American Society for Cell Biology 47th Annual Meeting December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

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54 The American Society for Cell Biology 47th Annual Meeting SUNDAY December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org

Washington, DC Convention Center, Halls A/B

Epithelia 77 B9 The EGF-like Repeats of 85 B17 Cytotoxicity of Nanoparticles on Thrombospondin-1 (TSP)-1 Activate Human Intestinal Cells. B. A. Koeneman,1 Y. Phospholipase (PL) C␥ and Increase Epithelial Zhang,2 K. Hristovski,2 P. Westerhoff,2 Y. Chen,2 J. 69 B1 Imaging Analysis of Vomeronasal Cell (EC) Migration through Epidermal Growth C. Crittenden,2 D. G. Capco1; 1School of Life Sensory Cell in Male Rats -[Ca2+] Is Evoked by Factor Receptor (EGFR) Activation. A. Liu,1 P. Sciences, Arizona State University, Tempe, AZ, Female Urinary Stimulation. H. Akutsu- Garg,1 S. Yang,1 P. Gong,1 D. S. Annis,2 M. A. 2Civil and Environmental Engineering, Arizona Yamauchi,1 J. Hitomi,2 Y. Satoh1; 1Department of Pallero,3 A. Passaniti,4 D. Mann,4 D. F. Mosher,2 J. State University, Tempe, AZ , School of Medicine, Iwate Medical Murphy-Ullrich,3 S. E. Goldblum4; 1Medicine and University, Morioka, Iwate, Japan, 2Department of Pathology, Mucosal Biology Research Center, 86 B18 The Drosophila Past1 Controls Anatomy, School of Medicine, Iwate Medical University of Maryland, Baltimore, Baltimore, MD, Germ Line Development and Is Essential for University, Morioka, Iwate, Japan 1 2Medicine, University of Wisconsin, Madison, WI, Survival of the Adult Fly. D. Segal, Y. Olswang- 2 2 2 3 3Pathology, University of Alabama at Birmingham, Kutz, Y. Gertel, S. Benjamin, E. Arama, H. 70 B2 Proper Expression of Epidermal 3 1,2 1 4 Steller, M. Horowitz ; Molecular Microbiology & Stratification Markers Requires Down-regulation Birmingham, AL, Greenebaum Cancer Center, Biotechnology, Tel-Aviv University, Tel-Aviv, Israel, of High Mobility Group Nucleosome (HMGN) Medicine and Pathology, Mucosal Biology 2Cell Research and Immunology, Tel-Aviv Proteins Expression. T. Furusawa, M. Bustin; Research Center, University of Maryland, University, Tel-Aviv, Israel, 3HHMI, Strang NCI, NIH, Bethesda, MD Baltimore, Baltimore, MD Laboratory of Cancer Research, The Rockefeller 71 B3 The Role of EGFR in the 78 B10 The Role of Canoe/Afadin in University, New York, NY Differentiation of Mucous Neck Cells in Rat Linking Actin to Adherens Junctions during 1 2 87 B19 Searching Drosophila for New Gastric Mucosa. L. H. Osaki, M. A. F. Curi, E. P. Morphogenesis. J. K. Sawyer, U. Gaul, M. 1 1 Genes Involved in Wound Healing. J. A. Geiger, Alvares, P. Gama; Cell and Developmental Biology, Peifer ; Biology, University of North 2 I. Campos, A. Santos, V. Carlos, A. Jacinto; University of Sao Paulo, Sao Paulo, Brazil Carolina–Chapel Hill, Chapel Hill, NC, Laboratory of Development Neurogenetics, Rockefeller Instituto de Medicina Molecular, Lisboa, Portugal 72 B4 The Transcription Factor University, New York, NY 88 B20 Genetic Control of Single Lumen Klf4 Controls Esophageal Epithelial 2+ Formation in the Zebrafish Gut. M. Bagnat, I. D. Differentiation and Cytoskeletal Organization In 79 B11 Comparison of Intracellular Ca Cheung, K. E. Mostov, D. Y. R. Stainier; University Vivo. M. Tetreault, B. Goldstein, Y. Yang, Q. Yu, A. Sequestration System between Peripheral of California, San Francisco, San Francisco, CA K. Rustgi, J. P. Katz; Medicine/Gastroenterology Limbus and Central Cornea Epithelia. Y. Shikanai, T. Saino, H. Akutsu-Yamauchi, Y. Satoh; Division, University of Pennsylvania, Philadelphia, 89 B21 Autophagy during Keratinization in Histology (Anatomy2), Iwate Medical University, PA the Normal Human Epidermis and of the Morioka, Japan Psoriatic Epidermis Characterized by 73 B5 Differentiation of a Murine Intestinal 1,2 80 B12 The Role of 14-3-3 Sigma in the Incomplete Keratinization. I. Tanida, K. Epithelial Cell Line (MIE) into M Cells. T. 3 3 3 2 1 2 1 1 Corneal Epithelial Maturation of the Er/+ Mouse. Haruna, Y. Suga, S. Muramatsu, T. Ueno, S. Kanaya, K. Miyazawa, I. Takakura, W. Itani, Y. 3 2 1 1 1 2 2 Ikeda, E. Kominami, K. Hanada ; Department of Akiyama,1 K. Watanabe,1 S. Ohwada,1 T. J. Shankardas, F. Liu, B. J. Herron, D. S. 1 1 1 Dimitrijevich3; 1UNT Health Science Center, Fort Biochemistry and Cell Biology, National Institute of Yamaguchi, H. Aso ; Laboratory of Functional 2 2 Infectious Disease, Tokyo, Japan, Department of Morphology, Graduate School of Agricultural Worth, TX, State University of New York, Albany, 3 Biochemistry, Juntendo University School of Science, Tohoku University, Sendai, Japan, NY, Integrative Physiology, UNT Health Science Medicine, Tokyo, Japan, 3Department of 2Section of Neuropathology, Department of Center, Fort Worth, TX Dermatology, Juntendo University School of Surgery, Yale Medical School, New Haven, CT 81 B13 Inhibition of Src and p38 MAP Medicine, Tokyo, Japan 74 B6 Induction of Transcription Kinases Suppresses De-differentiation of 90 B22 A Critical Role for Toll-like- Repressors Slug and Snail in Human RPE Cells. Primary Cultured Parotid Acinar Cells. J. Fujita- Receptor-4 in the Pathogenesis of Intestinal B. Chang,1 K. V. Chalam,2 L. Li,1 M. Hunt,1 R. C. Yoshigaki, M. Matsuki-Fukushima, H. Sugiya; Inflammation by Modulating Intestinal Injury Hunt1; 1Pathology and Microbiology, University of Department of Physiology, Nihon University School and Repair. C. Leaphart, J. Cavallo, S. Gribar, J. South Carolina School of Medicine, Columbia, SC, of Dentistry at Matsudo, Matsudo, Japan Li, M. Branca, T. Dubowski, J. Kohler, C. Sodhi, D. 2Ophthalmology, University of Florida School of 82 B14 Cholinergic Agonists Activate J. Hackam; Surgery, Children's Hospital of Medicine, Jacksonville, FL Phospholipase D via Rho/ROCK to Activate Pittsburgh, Pittsburgh, PA 75 B7 The Role of P2Y Receptor Signaling p42/p44 MAPK and Attenuate Protein Secretion 1,2 91 B23 Proteomic Characterization of and Epidermal Growth Factor Transactivation in in Rat Lacrimal Gland. R. R. Hodges, D. A. 1,2 1 Mouse Cytosolic and Membrane Prostate Corneal Epithelial Wound Healing. I. Boucher,1 Dartt ; Schepens Eye Research Institute, Boston, 2 Fractions: High Levels of Free SUMO Peptides V. Trinkaus-Randall1,2; 1Biochemistry, Boston MA, Department of Ophthalmology, Harvard Are Androgen-regulated. D. Caron,1 E. Winstall,2 University School of Medicine, Boston, MA, Medical School, Boston, MA S. Michaud,1 S. Bourassa,2 I. Kelly,2 G. Poirier,2 R. 2Ophthamology, Boston University School of 83 B15 An Epithelial Type II Cell System to Tanguay,3 R. Faure1; 1Department of Pediatrics, Medicine, Boston, MA Investigate Links between Environmental Laval University, Quebec, PQ, Canada, 2Proteomic 76 B8 Aconitase Activity Is Enhanced by a Factors and Lung Injury. K. K. Bernd,1 C. Platform, Laval University, Quebec, PQ, Canada, New Active Ingredient That Exhibits Anti-Aging Deforest Hauser,2 A. Nam,1 C. Raver,1 A. Weaver1; 3Department of Medicine, Laval University, Quebec, Properties. C. Gondran, C. Dal Farra, N. Domloge; 1Biology, Davidson College, Davidson, NC, PQ, Canada Skin Research Center, Vincience, ISP, Sophia 2Chemistry, Davidson College, Davidson, NC 92 B24 Changes in Gut Tissue Architecture Antipolis, France 84 B16 Cigarette Smoke Promotes Cell Induced by Mutations in APC. I. S. Nathke, I. Proliferation through Disturbance in Cellular Huggins, C. Lathwood, A. Quyn, P. Appleton; Redox Homeostasis of Transformed Lung School of Life Sciences, University of Dundee, Epithelial Type-II Cells. G. Kaushik, K. Lal Dundee, United Kingdom Khanduja, T. Kaushik, C. M. Pathak; Biophysics, Postgraduate Institute of Medical Education and Research, Chandigarh, India New and Emerging Technologies for Cell Biology I

93 B25 Development of an Analysis Tool to Quantitate the Biological Chondrogenic Differentiation Assay. B. T. Schmidt, B. M. Deasy; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA

55 SUNDAY The American Society for Cell Biology 47th Annual Meeting Poster Session 1 B26–B56 December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org

94 B26 The Photo-responsive Liposome as 104 B36 Cell-based Multi-Pathway Profiling 115 B47 Ku80 Removal from DNA through a Cargo of the Molecular Shuttle. A. Suzuki, M. Array: An Approach for siRNA Phenotype Double Strand Break-induced Ubiquitylation. L. Ito, S. Maruta; Division of Bioengineering, Graduate Analysis. Q. Jiang, A. Harris, Y. Wang, S. Tian, S. Postow,1 C. Ghenoiu,2,1 E. M. Woo,1 A. N. School of Engineering, Soka University, Tokyo, Lee, X. Zeng, L. Shen, V. Devgan; Cell Based Krutchinsky,1,3 B. T. Chait,1 H. Funabiki1,2; 1The Japan Assay and Automation, SuperArray Bioscience Rockefeller University, New York, NY, 2Weill Corporation, Frederick, MD Graduate School of Medical Sciences, Cornell 95 B27 Visualization of Molecular University, New York, NY, 3Department of Interactions In Situ. O. Soderberg; Department of 105 B37 A Tunable Genetic Switch Based Pharmaceutical Chemistry, University of California, Genetics & Pathology, Uppsala, Sweden on RNAi and Repressor Proteins for Regulating San Francisco, CA Gene Expression in Mammalian Cells. T. L. 96 B28 Lifeact - a Novel Versatile Marker Deans, C. R. Cantor, J. J. Collins; Biomedical 116 B48 Inhibition of RNA Polymerase I 1 for the Visualization of F-actin. J. Riedl, K. Engineering, Boston University, Boston, MA Transcription in Response to DNA Breaks Is 2 1 1 Kessenbrock, J. H. Yu, A. H. Crevenna, D. ATM-dependent. M. Kruhlak,1 E. Crouch,2 M. 3 3 2 4 Neukirchen, F. Bradke, D. Jenne, Z. Werb, M. 106 B38 Correlating mRNA Expression Orlov,2 C. Montano,2 S. Gorski,1 A. Nussenzweig,1 5 1 1 Sixt, R. Wedlich-Soldner ; Cellular Dynamics and Changes with Protein Expression Changes of T. Misteli,1 P. Robert,3 R. Casellas2; 1National Cell Patterning, Max-Planck-Institute of Multiple Cytokines Utilizing Real-Time PCR and Cancer Institute, National Institutes of Health, 2 Biochemistry, Martinsried, Germany, Department ELISA Arrays. E. Arikawa, M. You, J. Wang, J. Lo, Bethesda, MD, 2National Institute of Arthritis and of Neuroimmunology, Max-Planck-Institute of S. Yu, J. Yang; Research & Development, Musculoskeletal and Skin Diseases, National 3 Neurobiology, Martinsried, Germany, Axonal SuperArray Bioscience Corporation, Frederick, MD Institutes of Health, Bethesda, MD, 3Integrative Growth and Regeneration, Max-Planck-Institute of Bioinformatics, Los Altos, CA Neurobiology, Martinsried, Germany, 4Department 107 B39 Stable Oscillations via Quorum of Anatomy, University of California, San Francisco, Sensing in Virtual Bacteria. M. Footen, T. Otter; 117 B49 Telomere Length Regulation in San Francisco, CA, 5Department of Molecular Crowley Davis Research, Eagle, ID Aspergillus nidulans. M. Vahedi,1 S. M. Davis,1 Medicine, Max-Planck-Institute of Biochemistry, M. Meltser,1 P. M. Mirabito,2 K. E. Kirk1; 1Biology, Martinsried, Germany Chromatin and Chromosomes Lake Forest College, Lake Forest, IL, 2Biology, University of Kentucky, Lexington, KY 97 B29 Real-Time Dual-imaging of PIP2 Hydrolysis and Ca2+ in a Mechanically- 108 B40 A Molecular Motor as a Modulator 118 B50 Decondensation of Chromosomes stimulated Cell with a Single Excitation. A. of Interphase Chromatin Structure. M. by Topoisomerase II Reveals That Mitotic Tsukamoto,1 K. Nishimura,2 K. Furukawa,3 T. Mazumdar, M. Sung, T. Misteli; National Cancer Chromatin Is Constrained by DNA Ushida1; 1The Center for Disease Biology and Institute, NIH, Bethesda, MD Entanglements. R. Kawamura,1 L. H. Pope,1 M. Integrative Medicine, University of Tokyo, Tokyo, O. Chirestensen,2 J. F. Marko3; 1Physics, University 109 B41 Structure/Function Analysis of the Japan, 2Department of Mechanical Engineering, of Illinois at Chicago, Chicago, IL, 2Institut für University of Tokyo, Tokyo, Japan, 3Department of JIL-1 Histone H3S10 Tandem Kinase. X. Bao, H. Klinische Chemie und Laboratoriumsdiagnostik, Bioengineering, University of Tokyo, Tokyo, Japan Deng, W. Cai, J. Girton, J. Johansen, K. M. Universitätsklinikum Düsseldorf, Düsseldorf, Johansen; Biochemistry, Biophysics & Molecular Germany, 3Biochemistry, Molecular Biology, and 98 B30 Detecting the Active Conformation Biology, Iowa State University, Ames, IA Cell Biology, Northwestern University, Evanston, IL of Calpain with Calpastatin Peptides. D. E. Croall, L. M. Vanhooser, R. E. Cashon; 110 B42 Transcription Occurs on 119 B51 A Dynamic Mechanism for Biochemistry, Microbiology and Molecular Biology, Condensed Chromatin Templates - Large-Scale Streptococcus pyogenes Plasmid pSM19035 University of Maine, Orono, ME Chromatin Structure of Inducible BAC Segregation. Y. Suzuki,1 F. Pratto,2 J. C. Alonso,2 1 I. Kireev,1,2 M. Plutz,1 A. S. Transgenes. Y. Hu, K. Takeyasu1; 1Graduate School of Biostudies, Belmont1; 1Department of Cell and Developmental 99 B31 A New SUMO Fusion System for Kyoto University, Kyoto, Japan, 2Departamento de Enhancing Recombinant Protein Expression Biology, University of Illinois, Urbana–Champaign, Biotecnología Microbiana, Centro Nacional de 2Department of Electron Microscopy, and Facilitating Purification in Eukaryotic Cells. Urbana, IL, Biotecnología, CSIC, Madrid, Spain J. W. Bowen, L. Liu, C. Sanders, A. Karwa, R. J. A.N. Belozersky Institute of Physico-Chemical Peroutka, N. Elshourbagy, T. Panavas, T. R. Butt; Biology, Moscow State University, Moscow, 120 B52 Evidence and Models for LifeSensors, Inc., Malvern, PA Russian Federation Continuous Chromatin Structure. G. R. Green, D. P. Do; Pharmaceutical Sciences, Mercer 111 B43 In Vivo Visualization and 100 B32 Post-translational Modification University, Atlanta, GA Mapping of Endogenous Proteins. J. M. Characterization of Differential Epigenetic Sundstrom, P. E. Fort, T. W. Gardner, D. A. Patterns in Hair Follicle Stem Cells. J. Lee, T. 121 B53 A Role for the Chromosomally- Antonetti; Penn State College of Medicine, Tumbar; Molecular Biology & Genetics, Cornell encoded Plasmid Partitioning System in Origin Hershey, PA University, Ithaca, NY Segregation and Chromosome Organization. N. L. Sullivan, K. Marquis, D. Z. Rudner; Microbiology 112 B44 Polarization and Tethering of the 101 B33 Automated Genome-wide and Molecular Genetics, Harvard Medical School, Genome of S. cerevisiae. A. M. Tartakoff; Screening Using Cellular Microarray Imaging. N. Boston, MA Emans, A. Genovesio, Y. Kwon, N. Kim, H. Kim, S. Pathology, Case Western Reserve University, Choi, S. Jung, S. Cook; Institut Pasteur Korea, Cleveland, OH Seoul, Republic of Korea Ribonucleoproteins and RNA Localization 113 B45 The Effects of Repetitious Element 102 B34 High Resolution Genomic Analysis 1360 on Formation in 122 B55 EGF Increases the Interaction of Immortalized Human Cells. A. Kohara,1 M. Drosophila melanogaster. S. Shimonovich, S. between Nucleolin and Heterogeneous Nuclear Takeuchi,1 K. Takeuchi,1 Y. Ozawa,1 A. Ohtani,1 S. McDaniel, A. Figueroa-Clarevega, A. Wu, A. Wu, Ribonucleoprotein K/poly(C) Binding Protein 1 Shioda,1 H. Mizusawa,1 H. Makino,2 M. Terai,2 A. M. Dothager, S. C. R. Elgin, K. L. Huisinga; Complex to Regulate the Gastrin mRNA Umezawa2; 1National Institute of Biomedical Biology, Washington University in St. Louis, St. Turnover. P. Lee; Institution of Basic Medical Innovation, Osaka, Japan, 2National Research Louis, MO Science, Tainan, Taiwan Institute for Child Health and Development, Tokyo, 114 B46 Gene Position within Chromosome Japan 123 B56 Characterization of the Properties Territories Correlates with Involvement in of a Ribonucleoprotein Complex Regulating 103 B35 A Quantitative High-Throughput Intrachromosomal or Interchromosomal NFL mRNA Stability in Amyotrophic Lateral Screen Identifies Novel Potential Epigenetic Rearrangements. M. Gandhi,1,2 J. Stringer,3 M. Sclerosis. K. Volkening,1 C. Leystra-Lantz,1 M. J. Modulators of Gene Transcription. R. L. Nikiforova,1 M. Medvedovic,4,5 Y. Nikiforov1,2; Strong2; 1Cell Biology, Robarts Research Institute, Johnson,1 W. Huang,1 C. Austin,1 J. Inglese,1 E. 1Pathology, University of Pittsburgh, Pittsburgh, PA, London, ON, Canada, 2Department of Clinical Martinez2; 1NIH Chemical Genomics Center, 2Pathology, University of Cincinnati, Cincinnati, OH, Neurological Sciences, University of Western Bethesda, MD, 2Department of Pharmacology, 3Molecular Genetics, University of Cincinnati, Ontario, London, ON, Canada University of Texas Southwestern Medical Center, Cincinnati, OH, 4Center for Biostatistical Services, Dallas, TX University of Cincinnati, Cincinnati, OH, 5Division of Biomedical Informatics, Cincinnati Children's Hopsital Research Foundation, Cincinnati, OH

56 The American Society for Cell Biology 47th Annual Meeting SUNDAY December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org Poster Session 1 B57–B86

124 B57 Epigenetic Regulation by 135 B68 Association of EJC Components 145 B78 Analysis of the 3’ Untranslated Functional Non-Coding ncRNA Bioaptamers: and Export Factors with Nascent Pre-mRNAs. Regions of ␣-tubulin and S-crystallin mRNA in Mastergene Products for Vascularization and S. B. Patel,1 N. Novikova,2 M. Bellini2; Dark- and Light-adapted Octopus Retinas. S. D. Self-Tolerance of Tissue and Angiogenic Switch 1Biochemistry and College of Medicine, University Kelly, L. J. Robles; Biology, California State Functions in the Cancer Epigenome. J. H. of Illinois at Urbana–Champaign, Urbana, IL, 2Cell University, Dominguez Hills, Carson, CA Wissler; ARCONS Institute for Applied Research & Developmental Biology, University of Illinois at and Didactics, Bad Nauheim, Germany Urbana–Champaign, Urbana, IL 146 B79 Gene Expression Analysis Using Microarrays of Prion Positive and Negative 125 B58 A Role for Polypyrimidine Tract 136 B69 A Cryptic Splice Site in Flt1 RNA Yeast Strains. I. M. Evans,1 S. Zimmerman,1 J. Binding Protein in the Establishment of Focal Transcripts Revealed by Overexpression of Rogers,1 A. Watkins,1 J. Brothers,1 Y. Tra2; Adhesions. I. Babic, D. Black; Microbiology, RNA Processing Factor U2AF65. R. R. Pickin, W. 1Biological Sciences, Rochester Institute of Immunology and Molecular Genetics, University of R. Huckle; Biomedical Sciences, Virginia Tech, Technology, Rochester, NY, 2Mathematics and California, Los Angeles, Howard Hughes Medical Blacksburg, VA Statistics, Rochester Institute of Technology, Institute, Los Angeles, CA Rochester, NY

126 B59 Rho/ROCK Signaling Regulates Gene Structure and Expression the Delivery and Dynamics of a Cohort of Mechanisms of Nuclear Transcription mRNAs in Tumor Cell Protrusions. H. C. Stuart, 137 B70 Nucleolin Regulates c-Jun/Sp1- Z. Jia, A. Messenberg, B. Joshi, T. M. Underhill, H. dependent Transcriptional Activation of cPLA2␣ 147 B80 LPS-induced Prx I Upregulation Moukhles, I. R. Nabi; Cellular and Physiological in Phorbol Ester-treated Non-Small Cell Lung Requires Nrf2 Activation by Reactive Oxygen Sciences, University of British Columbia, Cancer A549 Cells. J. Tsou,1 W. Wang,1 K. Species and p38 MAP Kinase in BV-2 Microglia. Vancouver, BC, Canada Chang,2 J. Tseng,1 W. Su,2 W. Chang,3 B. Chen4; D. Lee,1 S. Kim,2 T. Lee3; 1Division of Animal 1Department of Pharmacology, National Cheng Biotechnology, Animal Resources Science, 127 B60 Visualizing Integrin mRNA Kung University, Tainan, Taiwan, 2Department of Kangwon National University, Chuncheon-si, Localization in Migrating Fibroblasts Using Internal Medicine, National Cheng Kung University, Gangwon-do, Republic of Korea, 2Laboratory of Molecular Beacons. F. Lennon, G. Bao; Tainan, Taiwan, 3Center for Gene Regulation and Human Genomics, Korea Research Institute of Department of Biomedical Engineering, Georgia Signal Transduction, National Cheng Kung Bioscience and Biotechnology, Daejeon, Republic Institute of Technology and Emory University, University, Tainan, Taiwan, 4Institute of Biosignal of Korea, 3Department of Oral Biochemistry, Atlanta, GA Transduction, National Cheng Kung University, College of Dentistry, Chonnam National University, 128 B61 Trafficking of ␤-Actin mRNA in Tainan, Taiwan Gwangju, Republic of Korea Neurons. K. Czaplinski, R. H. Singer; Anatomy 138 B71 Some Components of the 148 B81 CDK9 Regulates the Transcription and Structural Biology, Albert Einstein College of Transition Metal Induction of the of FGG Gene in Liver Cells. T. Hou, S. Ray, A. Medicine, Bronx, NY Saccharomyces cerevisiae ⌬-9 Fatty Acid Brasier; University of Texas Medical Branch, 129 B62 The N-Terminal Region of Tap/ Desaturase Gene Expression Act Independently Galveston, TX 1 1 NXF1 Mediates Homotypic Complex Assembly. of Hypoxic Controls. J. D. Mintz, C. OH, C. E. 2 1 149 B82 Characterization of Cells L. H. Matzat, L. Levesque; Cell and Developmental Martin ; Cell Biology and Neuroscience, Rutgers 2 Expressing RNA Polymerase II Tagged with Biology, University of Illinois at University, Piscataway, NJ, Cell Biology and Green Fluorescent Protein in Response to Urbana–Champaign, Urbana, IL Neuroscience, Rutgers University, Marlboro, NJ Ionizing Radiation. E. Hongo, Y. Ishihara, K. 130 B63 Perturbation of Cellular mRNA 139 B72 CC Chemokine Leukotactin-1/ Sugaya; Radiation Effect Mechanisms Research Nuclear Export by Human Papillomavirus E6 CCL15 Induces Human LZIP Expression Group, National Institute of Radiological Sciences, through Interaction with Gle1. P. Massimi, L. through NF-␬B Activation. K. Hyereen, S. Jang, Chiba, Japan Banks; ICGEB, Trieste, Italy Y. Kim, J. Ko; School of Life Sciences and Biotechnology, Korea University, Seoul, Republic of 150 B83 A Theoretical Study on 131 B64 Spermidine Synthase mRNA and Korea Transcription Factor Binding Events to DNA: 1D Spermatid Development in Marsilea vestita. F. vs. 3D Diffusion? V. Rezania, M. Hendzel, J. Deeb, C. M. Van der Weele, S. M. Wolniak; Cell 140 B73 Identification and Characterization Tuszynski; Division of Experimental Oncology, Biology and Molecular Genetics, University of of SUP8, a Histone H2A Gene with a Potential University of Alberta, Edmonton, AB, Canada Maryland, College Park, MD Role in Arabidopsis Defense Response. S. Salimian, L. Hua; Biological Sciences, University of 151 B84 Stat3 Activation Following 132 B65 Identification of PCBP2, a Maryland, Baltimore County, Baltimore, MD Hypoxia-Reoxygenation in Endothelial Cells Is Facilitator of IRES-mediated Translation, as a Regulated by Rac1 and Rac2, and Involves PKC Novel Constituent of Processing Body and 141 B73 Hemorrhagic Venom Induced Gene and MAPK Signaling Pathways. S. N. 1 1 1 Stress Granule. K. Fujimura, F. Kano, M. Murata; Expression in Human Umbilical Vein Mattagajasingh, K. Irani, I. Mattagajasingh, X. 1 2 2 2 1 Department of Liberal Arts and Sciences, Endothelial Cells. E. Albrecht, S. Tomlins, S. Yang, L. C. Becker ; Medicine, University of 2 1 2 University of Tokyo, Meguro-ku, Japan Dhanasekaran ; Biology and Physics, Kennesaw Pittsburgh, Pittsburgh, PA, Medicine, Johns State University, Kennesaw, GA, 2Pathology, Hopkins University, Baltimore, MD 133 B66 Localization of mRNA Export University of Michigan, Ann Arbor, MI Factors to Cytoplasmic RNA-containing 152 B85 Concurrent Fast and Slow Cycling Granules in Response to Stress in Human and 142 B75 The Effect of Foreign DNA on RNA of a Transcriptional Activator at an Endogenous 1 1 1 2 Yeast Cells. S. R. Carmody,1 J. J. Scarcelli,2 S. Processing in the Host Cell. H. M. Mansour, B. Promoter. T. S. Karpova, M. J. Kim, C. Spriet, 2 3 1 1 1 2 Guo,1 C. N. Cole,2 S. R. Wente1; 1Department of Lam, Y. Haj-Ahmad ; Biological Science, Brock K. Nalley, T. Stasevich, Z. Kherrouche, L. 2 2 1 1 Cell and Developmental Biology, Vanderbilt University, St. Catharines, ON, Canada, Norgen Heliot, J. G. McNally ; Laboratory of Receptor University Medical Center, Nashville, TN, Biotek Corporation, Thorold, ON, Canada, Biology and Gene Expression, NCI-NIH, Bethesda, 3 2 2Department of Biochemistry, Dartmouth Medical Biotechnology, Brock University, St. Catharines, MD, Institut de Biologie de Lille, Lille, France School, Hanover, NH ON, Canada 153 B86 NRIP, a Coactivator of AR, Is 134 B67 Coilin in the Cajal Body and the 143 B76 Yeast Phospholipase C Regulates Regulated by AR and Sp1 to Feed-Forward Histone Locus Body. Z. F. Nizami,1,2 J. Liu,1 H. Transcription of Msn2p-dependent Stress Activate Its Own Gene Expression through AR 1 2 1 Gao,1 Z. Wu,1 J. G. Gall1; 1Embryology, Carnegie Responsive Genes. K. Guzinska, A. Demczuk, L. Protein Stability. P. Chen, Y. Tsao, C. Wang, S. 1 1 Institution, Baltimore, MD, 2Biology, The Johns Galdieri, A. Vancura; Biological Sciences, St. Chen ; Graduate Institute of Microbiology, National 2 Hopkins University, Baltimore, MD John's University, Queens, NY Taiwan University, Taipei, Taiwan, Department of Ophthalmology, Mackay Memorial Hospital, Taipei, 144 B77 Microarray Analysis of Gene Taiwan Expression of Sacchromyces bayanus after Exposure to ␣- factor. C. Young,1 A. A. Caudy2; 1Spelman College, Atlanta, GA, 2Princeton University, Princeton, NJ

57 SUNDAY The American Society for Cell Biology 47th Annual Meeting Poster Session 1 B87–B118 December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org

154 B87 Cloning, Expression, and 164 B98 Phosphoinositide Binding by 175 B109 By-Pass Suppressors of Cold- Identification of Interacting Partner Proteins of Nucleoside Diphosphate Kinase (NDKB) Sensitive ER-associated Degradation (ERAD) Transcription Corepressor Human Sin3B. H. Mediates Endoplasmic Reticulum (ER) Network Mutations. J. Ballou, L. Eleftheriou, J. Ellingboe, A. Batra, V. Kumar, D. Saluja; Medical Biotechnology Formation. J. Morin-Leisk,1 C. Baughman,2 J. Goracke, D. Malayter, G. Souto-Adeva, N. Baltes, Lab, Dr. B. R. Ambedkar Center for Biomedical Pokusa,1 T. H. Lee1; 1Biological Sciences, M. Teisberg, R. Wright; Department of Genetics, Research, Delhi, India Carnegie Mellon University, Pittsburgh, PA, Cell Biology, and Development, University of 2Program in Cell, Molecular and Developmental Minnesota, Minneapolis, MN 155 B88 The Decapping Activator Lsm1p- Biology, Tufts University, Boston, MA 7p-Pat1p Complex Has the Intrinsic Ability to 176 B110 Regulation of Ubiquitin- Distinguish between Oligoadenylated and 165 B99 Investigation of BAP31 Homologs Proteasome System-mediated Degradation by Polyadenylated RNAs. A. K. Chowdhury, J. in Yeast. J. D. Wilson, C. Barlowe; Biochemistry, Cytosolic Stress. L. Musil, S. Kelly, J. VanSlyke; Mukhopadhyay, T. Sundaresan; Biochemistry & Dartmouth Medical School, Hanover, NH Biochemistry and Molecular Biology, Oregon Health Molecular Biology, Uniformed Services University of & Science University, Portland, OR Health Sciences, Rockville, MD 166 B100 A Coiled-Coil ER Protein, p180, Affects Organization of the Endoplasmic 177 B111 A Cell-based Assay for the 156 B89 TIP60 Induces Neuronal Reticulum through Microtubule Bundling. K. Function of GRP94. C. A. Makarewich,1 O. Differentiation through the Repression of p73 Ogawa-Goto,1,2,3 K. Tanaka,2 T. Ueno,1 K. Ostrovsky,1 T. Gidalevitz,2 C. Biswas,1 E. L. Transcriptional Activity. J. Kim, S. Jang, K. Song, Tanaka,1 T. Sata,2 S. Irie1,3; 1Nippi Research Snapp,3 Y. Argon1; 1Division of Cell Pathology, K. Choi; Laboratory of Molecular Biology, College Institute of Biomatrix, Ibaraki, Japan, 2NIID, Tokyo, Children's Hospital of Philadelphia, and the of Natural Science, Chung-Ang University, Seoul, Japan, 3Japan Institute of Leather Research, University of Pennsylvania, Philadelphia, PA, Republic of Korea Tokyo, Japan 2Department of Pathology, the University of Chicago, Chicago, IL, 3Department of Anatomy and 157 B90 Regulation of Insulin Secretion by 167 B101 Exploration of Endoplasmic Structural Biology, Albert Einstein College of the Nucleosome Binding Protein HMGN3. T. Reticulum Organization during Cell Division in Medicine, New York, NY Ueda, T. Furusawa, M. Bustin; NIH, Bethesda, MD Caenorbaditis elegans Embryos. D. Bienkowska, J. M. Squirrell, J. G. White; Laboratory of Molecular 178 B112 Searching for Local Ca2+ 158 B91 The Expression of Myelid-1-like Biology, University of Wisconsin–Madison, Alterations during Cell Death from Noisy Data. Factor (MEF/Elf4), an ETS Transcription Factor, Madison, WI M. B. Hong,1 P. M. Keeney,2 K. E. Bergquist,2 J. P. 1 1 Is Modulated by p53. M. Taura, K. Komatsu, A. Bennett2; 1Biomedical Engineering, University of 1 1 2 3 1 Eguma, T. Koga, N. Araki, H. Saya, M. Suico, 168 B102 Constitutive, Translation- Virginia, Charlottesville, VA, 2Neurology, University 1 1 1 T. Shuto, H. Kai ; Molecular Medicine, Graduate independent Opening of the Protein-conducting of Virginia, Charlottesville, VA School of Pharmaceutical Sciences, Kumamoto Channel in the Endoplasmic Reticulum. W. F. University, Kumamoto, Japan, 2Tumor Genetics Wonderlin; Biochemistry & Molecular Biology, West 179 B113 Characterization of Dimeric and Biology, Graduate School of Pharmaceutical Virginia University, Morgantown, WV Formation between ATF6 and CREB-H under ER Sciences, Kumamoto University, Kumamoto, Stress. H. Kim, H. Song, D. Lee; Life Sciences, Japan, 3Division of Gene Regulation, Institute for 169 B103 Secretory Protein Signal University of Seoul, Seoul, Republic of Korea Advanced Medical Research, Keio University Sequences Reconsidered: Regulatory School of Medicine, Tokyo, Japan Sequences Beyond the Signal Sequence. D. E. 180 B114 Oxidative Stress in the Russel, E. L. Snapp; Anatomy & Structural Biology, Endoplasmic Reticulum: Not So Stressful? C. 159 B92 Lamin B1 in the Nuclear Lamina Albert Einstein College of Medicine, Bronx, NY W. Lai, E. L. Snapp; Anatomy and Structural Sequesters Oct-1 to Regulate Gene Expression. Biology, Albert Einstein College of Medicine, Bronx, D. J. Vaux, A. N. Malhas; William Dunn School of 170 B104 Subcellular Fractionation of RBL NY Pathology, Oxford University, Oxford, United Mast Cells Reveals Two Populations of ER Kingdom Membranes Relevant to Calcium Mobilization. 181 B115 The 13 kDa Prolamin Fused to S. Hammond, D. Holowka, B. Baird; Chemistry and Green Fluorescent Protein Accumulates Not 160 B93 Elucidating a Role for Btf in Pre- Chemical Biology, Cornell University, Ithaca, NY Only in the Seeds, but Also in the Vegetative Messenger RNA Transcription and Splicing. S. Tissues of Transgenic Rice. Y. Saito, K. Kishida, Varia,1 Z. Deng,1 A. Sharma,1 A. Bubulya,2 P. A. 171 B105 Regulation of GRP94 Expression K. Takata, H. Takahashi, T. Shimada, K. Tanaka, S. Bubulya2; 1Biomedical Sciences Ph.D. Program, in Myogenic and Adipogenic Differentiation Morita, S. Satoh, T. Masumura; Kyoto Prefectural Wright State University, Dayton, OH, 2Biological under ER Stress. H. Song, H. Kim, D. Lee; Life University, Kyoto, Japan Sciences, Wright State University, Dayton, OH Sciences, University of Seoul, Seoul, Republic of Korea 182 B116 Distribution of Storage Proteins 161 B94 Regulation of the Calreticulin in Whole Area of Rice Grain Determined Using Gene by GATA6 and Evi-1 Transcription 172 B106 Effect of Taurine on Adipogenic Fresh-Frozen Sections from Dry Seeds. T. Factors. Y. Qiu,1 J. Lynch,1 L. Guo,2 A. Perkins,3 Differentiation in 3T3 L1 under ER Stress. I. Masumura,1,2 N. Nakatsuka,1 Y. Saito,1 T. M. Michalak1; 1Biochemistry, University of Alberta, Choi, D. Lee; Life Sciences, University of Seoul, Shigemitsu,1 S. Morita,1,2 S. Satoh1,2; 1Genetic Edmonton, AB, Canada, 2Hepatic Toxicology, Seoul, Republic of Korea Engineering, Kyoto Prefectural University, Kyoto, National Center for Toxicological Research, Food Japan, 2Genetic Engineering, Kyoto Prefectural 173 B107 Endoplasmic Reticulum Stress and Drug Administration, Jefferson, AR, Institute of Agricultural Biotechnology, Seika-cho, Induces Dedifferentiation and an Epithelium- 3Pathology, Yale University, New Haven, CT Japan Mesenchyme Transition-like Phenotype in 162 B95 Dynamic Changes in the Thyroid PC Cl3 Cells: Involvement of C-Src. L. 183 B117 The Yeast Dsl1p Secretory 1 2 2 3 Organization of Glucocorticoid Receptor and Ulianich, C. Garbi, D. Punzi, S. De Vitis, A. Complex Is Involved in Peroxisome Biogenesis. 3 2 2 1 RNA Polymerase II Clusters Support Formation Lombardi, G. Raciti, F. Beguinot, E. Consiglio, R. J. Perry, R. A. Rachubinski; Cell Biology, 3 1 2 of Polarized Chromatin Loops during B. Di Jeso ; IEOS, Napoli, Italy, DBPCM, Napoli, University of Alberta, Edmonton, AB, Canada 3 Transcription. H. Htun,1 R. S. Singh,1 W. J. Italy, DiSTeBA, Lecce, Italy Dixon2; 1Ob-Gyn and Molecular & Medical 184 B118 Domain-containing 174 B108 Cold Adaptation and Growth of Proteins, Pex30p and Pex31p, Control the Pharmacology, David Geffen School of Medicine at Yeast at Low Temperatures Involves Diverse UCLA, Los Angeles, CA, 2Biological Sciences, Number and Size of Oleate-induced Cellular Functions and Physiological Peroxisomes in Pichia pastoris. M. Yan,1 D. A. California State Polytechnic University–Pomona, 1 1 2 Processes. A. Felthauser, J. Ballou, M. Bard, R. Rachubinski,2 R. A. Rachubinski,2 S. Subramani1; Pomona, CA 1 1 Wright ; Department of Genetics, Cell Biology, and 1Section of Molecular Biology, University of Development, University of Minnesota, California San Diego, La Jolla, CA, 2Department of 2 Endoplasmic Reticulum Minneapolis, MN, Department of Biology, Indiana Cell Biology, University of Alberta, Edmonton, AB, University–Purdue University, Indiananapolis, Canada Indianapolis, IN 163 B97 Role and Function of Reticulons in Maintaining ER Tubules. C. Voss, W. Prinz; NIH, Bethesda, MD

58 The American Society for Cell Biology 47th Annual Meeting SUNDAY December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org Poster Session 1 B119–B149

Signal Transduction in Development I 196 B130 Characterizing a Novel Role for 206 B140 Fibronectin Matrix Induces the Metabolic Gene pnc-1 in Cell Fate Embryonic Stem Cell Differentiation. A. J. Specification in C. elegans. T. L. Vrablik, L. Engler,1 C. Schaniel,2 I. R. Lemischka,2 J. E. 185 B119 CnrN, a PTEN-like Protein, Huang, W. Hanna-Rose; Biochemistry & Molecular Schwarzbauer1; 1Molecular Biology, Princeton Regulates the Size of a Group of Cells in Biology, Pennsylvania State University, University University, Princeton, NJ, 2Gene and Cell Medicine, Dictyostelium. Y. Tang, R. Gomer; Biochemistry & Park, PA Mount Sinai School of Medicine, New York, NY Cell Biology, Rice University, Houston, TX 197 B131 CED-10/Rac-1 Mediates 207 B141 Defining Embryonic Stem Cell 186 B120 Two Roles for an Anti-Adhesive Asymmetric Distribution of MIG-10/Lamellipodin Derived Therapeutic Osteogenic Populations. J. Protein during Growth and Development of to Orient Axon Growth. C. C. Quinn, D. S. Pfeil, E. DeMarco, S. K. Bronson; Cellular and Molecular Dictyostelium. D. D. Blumberg, E. Ford, J. S. W. G. Wadsworth; Pathology, UMDNJ–RWJMS, Physiology, Penn State University, Hershey, PA Kelsey, C. Petty, Y. Zhang, S. Steiner; Department Piscataway, NJ of Biological Sciences, University of Maryland, 208 B142 A Heterogeneous Population of Baltimore County, Baltimore, MD 198 B132 Immune Functions of Mussel Muscle-derived Cells Exhibits Greater Haemocytes Are Regulated by PI 3-K, PKC, and Chondrogenic and Osteogenic Potential than 187 B121 A Role for ␥-Secretase in ERK Kinases. E. Garcia-Garcia, C. Rosales; Do More Purified Populations. G. Li, B. Zheng, L. Fertilization in Chlamydomonas. Q. Wang,1 Y. Immunology, Instituto de Investigaciones B. Meszaros, A. Usas, K. A. Corsi, J. Huard; Hao,2 W. Liu,2 S. Shah,1 G. Yu,2 W. J. Snell1; 1Cell Biomedicas - UNAM, Mexico City, Mexico University of Pittsburgh, Pittsburgh, PA Biology, UT Southwestern Medical Center, Dallas, 2 TX, Center for Basic Neuroscience, UT 209 B143 Multipotent Myogenic Progenitors Southwestern Medical Center, Dallas, TX Stem Cells Identified from Murine and Bone Marrow Play Different Roles in Muscle 188 B122 A New Drosophila Model to Regeneration. Z. Qu-Petersen,1 P. Schjerling2; Study the Genetic Interactions of Cas Proteins. 199 B133 Pluripotency of Adult Human 1 1Copenhagen Muscle Research Centre, National N. Tikhmyanova, F. Roegiers, E. Golemis; Fox Spermatogonial Stem Cells. N. Golestaneh, M. 1 1 1 2 University Hospital, Copenhagen, Denmark, Chase Cancer Center, Philadelphia, PA Kokkinaki, J. Jiang, Z. He, D. DeStefano, C. Fernandez-Bueno,2 I. Gallicano,1 M. Dym1; 2Molecular Muscle Biology, Copenhagen Muscle 189 B123 Drosophila APC2 APC1 Null 1Biochemistry and Molecular & Cellular Biology, Research Centre, National University Hospital, Epithelial Clones Exhibit Wingless Pathway Georgetown University Medical Center, Copenhagen, Denmark Dependent Cell Shape Changes and Epithelial Washington, DC, 2Washington Regional Transplant 210 B144 Investigation of Multipotent Myo- Misfolding. S. G. Zimmerman, L. M. Thorpe, C. A. Consortium, Annandale, VA endothelial Cell Clones Isolated from Adult Mallozzi, V. R. Medrano, B. M. McCartney; Human Skeletal Muscle. B. Zheng; Orthopaedic Department of Biological Sciences, Carnegie 200 B134 Possible Role(s) of STAT3 Surgery, Stem Cell Research Center, University of Mellon University, Pittsburgh, PA Downstream Genes in the Maintenance of mES Cells. D. Kim,1 Y. Song,1 S. Hong1,2; 1School of Pittsburgh, Pittsburgh, PA 190 B124 Modulation of MAPK Activities Biological Sciences, Seoul National University, 211 B145 Isolation and Characterization of during Egg Activation in Drosophila. K. L. Seoul, Republic of Korea, 2Institute of Molecular GFRA1-Positive Spermatogonial Stem Cells in Sackton, N. A. Buehner, M. F. Wolfner; Cornell, Biology and Genetics, Seoul National University, Immature Mice. M. Kokkinaki,1 T. Lee,2 Z. He,1 J. Ithaca, NY Seoul, Republic of Korea Jiang,1 N. Golestaneh,1 W. Chan,2 M. Hofmann,3 191 B125 A Genome-wide Screen in 201 B135 Functional Characterization of M. Dym1; 1Biochemistry and Molecular & Cellular Cultured Drosophila Cells Identifies a Novel the Oct-4B Variant of the Human Oct-4 Biology, Georgetown University, Washington, DC, Role for the Sodium-Proton Exchanger 3 (Nhe3) Transcription Factor. J. Lee,1 H. Kim,1 Y. Han,2 J. 2National Institute of Child Health and Human in Wnt Signaling. M. Simons,1 T. J. Klein,1 W. Kim1; 1Sogang University, Seoul, Republic of Development, NIH, Bethesda, MD, 3Department of Gault,1 D. Gotthardt,2 J. Dow,3 M. Boutros,4 M. Korea, 2Korea Advanced Institute of Science and Veterinary Biosciences, University of Illinois, Mlodzik1; 1Molecular Cell and Developmental Technology, Daejeon, Republic of Korea Urbana, IL Biology, Mount Sinai School of Medicine, New 212 B146 Molecular Characterization of York, NY, 2Internal Medicine IV, University Hospital 202 B136 Histone Mobility and Nuclear Self-Renewing, Oct4-Expressing Yolk Sac Heidelberg, Heidelberg, Germany, 3Division of Architecture in Human Embryonic Stem Cells. 1 2 3 Endoderm Precursor Cells. B. G. Debeb,1 V. Molecular Genetics, IBLS, Glasgow, United P. J. Sammak, P. Rodriguez-Collazo, K. N. Dahl, 4 5 2 Galat,2 J. Epple-Farmer,1 S. Adhikari,1 P. Kingdom, 4German Cancer Research Center, S. Horvath, O. Christianson, S. Leuba, E. P. 6 1 7 7 Iannaccone,2 B. Binas1; 1Veterinary Pathobiology, Heidelberg, Germany Jane, T. M. Erb, C. Jeffreys, M. Desai, R. Mangoubi7; 1Ob/Gyn/Reproductive Sciences, Texas A&M University, College Station, TX, 192 B126 Drosophila Auxilin Regulates University of Pittsburgh, Pittsburgh, PA, 2Cell 2Children’s Memorial Research Center, Notch Signaling by Facilitating Ligand Biology and Physiology, University of Pittsburgh, Northwestern University, Chicago, IL Internalization. V. Kandachar, T. Bai, H. Chang; Pittsburgh, PA, 3Bioengineering, Carnegie Mellon 213 B147 An Automated Membrane-based Purdue University, West Lafayette, IN University, Pittsburgh, PA, 4Bioengineering, Method for the Expansion and Neural University of Pittsburgh, Pittsburgh, PA, 5Physics, Differentiation of Embryonic Stem Cells. L. 193 B127 CaM Kinase II in Adult Wild-type Carnegie Mellon University, Pittsburgh, PA, 6Magee Kellard,1 S. Sheridan,1 M. Wilgo,1 J. Merlino,2 J. and Eye-color Mutant Drosophila melanogaster Womens Research Institute, University of Goode2; 1Stem Cells/Cell Biology, Millipore, Is Differentially Expressed and Influenced by Pittsburgh, Pittsburgh, PA, 7Bioengineering, Draper Danvers, MA, 2Tecan US, Research Triangle Park, Light. R. Pu, P. Pontoriero, E. Jabeen, S. Moore, Laboratories, Cambridge, MA S. Patel; Biology, Kean University, Union, NJ NC 203 B137 A Stem Cell-specific miR-302b Is 214 B148 Membrane Based Isolation and 194 B128 The Role of the Jun N-terminal Indispensable for Maintaining Pluripotency. J. Characterization of Stem Cell Derived Neurite Kinase (JNK) Signalling Pathway in Neuronal Kim,1 M. Lee,1 S. Moon,2 K. Hong,1 W. Cho,1 K. Outgrowths. S. Sheridan, M. Wilgo, S. Gil, L. Morphogenesis. A. S. Rallis; MRC Centre for Kim1; 1Department of Anatomy and Cell Biology, Kellard; Stem Cells/Cell Biology, Millipore, Danvers, Developmental Neurobiology, King's College Hanyang University, Seoul, Republic of Korea, MA London, United Kingdom 2Pochon CHA University, Seoul, Republic of Korea 215 B149 Laminin Nanofiber Mesh 195 B129 Frazzled P-motifs Are 204 B138 MicroRNAs Mediate the Switch Substrates for Stem Cell Growth and Differentially Required for Axon Pathway between ES Cell Self-Renewal and Differentiation. S. G. McClugage,1 M. Link,1 R. A. Formation in the Drosophila Embryonic CNS. B. Differentiation via Silencing of STAT3. K. M. Neal,2 R. A. Ogle,1 E. A. Botchwey,2 R. C. Ogle1,3; E. Varughese, J. N. Dorsten, M. F. A. VanBerkum; Foshay, G. I. Gallicano; Cell Biology, Georgetown 1Center for Immunity, Inflammation and Dept. Biological Sciences, Wayne State University, University, Washington, DC Detroit, MI Regenerative Medicine, University of Virginia, 205 B139 Developmental Specification of Charlottesville, VA, 2Biomedical Engineering, the Adult Neural Stem Cell Niche. T. University of Virginia, Charlottesville, VA, Ghashghaei; Molecular Biomedical Sciences, North 3Department of Medicine, University of Virginia, Carolina State University, Raleigh, NC Charlottesville, VA

59 SUNDAY The American Society for Cell Biology 47th Annual Meeting Poster Session 1 B150–B179 December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org

216 B150 User-Friendly Calculator to Stem Cell Biology 236 B170 The Wnt/␤-Catenin Pathway Obtain Cell Growth Parameters. S. L. Sanford,1,2 Regulates Spermatogonial Stem Cells. N. B. M. Deasy3,2; 1Biological Sciences, Carnegie Golestaneh,1 E. Beauchamp,2 K. Chen,2 S. Fallen,2 226 B160 Asymmetric Stem Cell Division Mellon University, Pittsburgh, PA, 2Live Cell A. Üren,2 M. Dym1; 1Biochemistry and Molecular & during Tissue Homeostasis and Aging. N. Imaging Lab, Stem Cell Research Center, Cellular Biology, Georgetown University Medical Turkel,1 N. Hemati,1 M. T. Fuller,2 Y. M. Pittsburgh, PA, 3Biomedical Engineering and Center, Washington, DC, 2Lombardi Cancer Center, Yamashita1; 1Center for Stem Cell Biology, Orthopaedic Surgery, University of Pittsburgh, Georgetown University Medical Center, University of Michigan, Ann Arbor, MI, Pittsburgh, PA Washington, DC 2Departments of Developmental Biology and 217 B151 A Quantitative Scheme to Genetics, Stanford University, Stanford, CA 237 B171 The Mouse Mammary Estimate Proliferation, Differentiation, and Microenvironment Redirects Spermatogenic, 227 B161 Impaired Embryonic Stem Cell Dedifferentiation for Embryonic Stem Cells. W. Neural, and Marrow Cells to a Mammary Differentiation by Aberrant Expression of the Huang,1 B. M. Raaka,2 C. C. Chow1; 1Laboratory of Epithelial Progenitor Cell Fate. C. A. Boulanger,1 Nucleosome Binding Protein HMGN1. S. Biological Modeling, National Institute of Diabetes B. W. Booth,1 D. L. Mack,1 A. Androutsellis- Cherukuri, E. Rand, M. Bustin; Protein Section, and Digestive and Kidney Diseases, NIH, Theotokis,2 M. Rosu-Myles,3 L. Wolff,3 R. McKay,2 Laboratory of Metabolism, National Cancer Bethesda, MD, 2Clinical Endocrinology Branch, G. H. Smith1; 1MBTL, CCR, NCI, NIH, Bethesda, Institute, National Institutes of Health, Bethesda, National Institute of Diabetes and Digestive and MD, 2LMB, NINDS, NIH, Bethesda, MD, 3LCO, MD Kidney Diseases, NIH, Bethesda, MD CCR, NCI, NIH, Bethesda, MD 228 B162 miR-124a Regulates Cell 218 B152 NMR Detects Common Traits in 238 B172 The Transcription Factor RUNX1 Adhesion and Polarity of Differentiating hESC Pluripotent Murine Embryonic Stem Cells and Controls Stem Cell Activation in the Hair through IQGAP1. M. Lee, J. Kim, K. Kim; Their Malignant Counterparts. H. M. Romanska,1 Follicle. K. M. Osorio, S. Lee, D. McDermitt, Y. Department of Anatomy and Cell Biology, Hanyang S. Tiziani,2 R. Howe,1 U. Gunther,2 E. Lalani1; Zhang, S. Whagmare, T. Tumbar; Molecular University, Seoul, Republic of Korea 1Pathology, University of Birmingham, Birmingham, Biology and Genetics, Cornell University, Ithaca, United Kingdom, 2HW-NMR Group, University of 229 B163 A Novel Function of Calreticulin NY Birmingham, Birmingham, United Kingdom as an Inhibitor of Adipogenesis. E. Szabo,1 Y. 239 B173 Proliferation-coupled Astrocytic Qiu,2 S. Baksh,2 M. Michalak,2 M. Opas1; 219 B153 Computational Models of Differentiation of Neural Stem Cells in the Adult 1University of Toronto, Toronto, ON, Canada, Epithelial Morphogenesis. M. Vail, T. Otter; Brain. J. M. Encinas, A. Koulakov, G. Enikolopov; 2University of Alberta, Edmonton, AB, Canada Crowley Davis Research, Eagle, ID Cold Spring Harbor Laboratory, Cold Spring 230 B164 The Brown Adipocyte Harbor, NY Differentiation Pathway in Birds, a Clade That Invertebrate Development 240 B174 Acyl-coA Synthetase 4 Is Lacks Brown Fat. N. Mezentseva,1 J. S. Involved in Neural Differentiation of Mouse Kumaratilake,2 S. A. Newman1; 1Cell Biology and Embryonic Stem Cells. H. Y. Park, S. M. Lee, H. 220 B154 Sponge Body Associated Anatomy, New York Medical College, Valhalla, NY, M. Kim, S. J. Moon, M. J. Kang; Department of Proteins Trailer Hitch and BicaudalC Act 2Anatomical Sciences, University of Adelaide, Animal Science, Chonnam National University, Together in and Membrane Adelaide, Australia Organization. M. J. Snee, P. M. Macdonald; Gwangju, Republic of Korea Molecular Cell and Developmental Biology, 231 B165 Chondrogenic Potential of 241 B175 LIS1-Nde1 Dependent Neuronal University of Texas at Austin, Austin, TX Wharton’s Jelly-derived Stem Cells through Fate Control Determines Cerebral Cortical Size Growth Factor Induction. R. C. Schugar,1 B. T. and Lamination. Y. Feng, A. S. Pawlisz; 221 B155 A Unified Picture of the Early Schmidt,2 B. M. Deasy3; 1University of Pittsburgh, Neurology; Genetics, Northwestern University Drosophila Embryo Patterning: The Maternal Wexford, PA, 2Bioengineering, University of School of Medicine, Chicago, IL Gradients of the Syncytium. M. Coppey, A. Pittsburgh, Pittsburgh, PA, 3Departments of Boettiger, S. Shvartsman; Princeton University, Orthopedic Surgery and Bioengineering, University 242 B176 Expression of Embryonic and Princeton, NJ of Pittsburgh, Pittsburgh, PA Adult Stem Cell Markers during Expansion of CD133+ Umbilical Cord Blood-derived Stem 222 B156 Domain Analysis to Dissect the 232 B166 Cell Shape Switches TGF␤- Cells. M. C. Howe,1 J. Zhao,1 Y. Bodenburg,1 C. Role of Drosophila PINCH in Epithelial induced Human Mesenchymal Stem Cell McGuckin,2 N. Forraz,2 R. Tilton,1 R. Urban,1 L. Adhesion and Migration. M. C. Elias, J. L. Differentiation between Chondrogenic versus Denner1; 1Internal Medicine, University of Texas at Kadrmas, M. C. Beckerle; Oncological Sciences, Myogenic Lineages through Rac1. L. Gao,1 R. Galveston, Galveston, TX, 2Human Genetics and University of Utah, Salt Lake City, UT McBeath,2 C. Chen1; 1Bioengineering, University of North East England Stem Cell Institute, Newcastle Pennsylvania, Philadelphia, PA, 2The Cellular and 223 B157 BiFluorescence Complementation University, Newcastle, United Kingdom Molecular Medicine Program, The Johns Hopkins Reveals Dynamics of JNK Signalling in the University School of Medicine, Baltimore, MD Drosophila Embryo. J. W. Bloor, A. Barrett, L. Ma, 243 B177 Hematopoietic Regulatory Factors: Intrinsic Compared to Insoluble D. Clyde; Department of Biosciences, University of 233 B167 Cell Shape Regulates BMP- Extrinsic. X. Du, S. T. Chao, F. Rehfeldt, D. E. Kent, Canterbury, United Kingdom induced SMAD Signaling and Osteogenesis in Discher; Molecular & Cell Biophysics, University of Human Mesenchymal Stem Cells through RhoA. 224 B158 Whole-Genome Approaches Pennsylvania, Philadelphia, PA Y. Wang,1 L. Gao,1 M. T. Yang,1 C. Q. Cheng,1 D. Using Chromatin Immunoprecipitation to M. Cohen,1 S. A. Ruiz,2 D. M. Pirone,1 C. S. Identify cis-regulatory Elements Controlling 244 B178 Stem Cells in the Cichlasoma Chen1; 1Bioengineering, University of Pennsylvania, Dorsoventral Patterning of Drosophila Embryos. octofasciatum Retina Differentiate into Rod Philadelphia, PA, 2Biomedical Engineering, Johns A. Ozdemir, M. Samanta, A. Stathopoulos; Division Photoreceptors. E. G. Holvey-Bates, A. J. Hopkins University, Baltimore, MD of Biology, California Institute of Technology, Ettinger; Biological Sciences, Cedar Crest College, Allentown, PA Pasadena, CA 234 B168 Menin Expression Alters the Ratio of Mesenchymal Cell Commitment into 225 B159 JNK Is Required for Normal 245 B179 Lasp Regulates Somatic Stem Myogenic and Osteogenic Lineages. A. Aziz, T. Cleavage and Morphogenesis of the Cell Maintenance in the Drosophila Testis. S. Miyake, J. C. McDermott; Biology, York University, Archenteron in the Sea Urchin Embryo. L. E. Lee, F. Schöck; Department of Biology, McGill Toronto, ON, Canada Irwin, M. K. Wright, L. N. Moll, W. K. Zurat, J. D. University, Montreal, PQ, Canada Hamberger, E. L. Wagner, M. T. Peeler; Biology, 235 B169 Downregulation of PKG and PKC Susquehanna University, Selinsgrove, PA Enhances Differentiation of Non-beating Embryonic Stem Cells into Beating Cardiomyocytes. S. Mobley, K. Foshay, G. Gallicano; Department of Biochemistry and Molecular & Cellular Biology, Georgetown University Medical Center, Washington, DC

60 The American Society for Cell Biology 47th Annual Meeting SUNDAY December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org Poster Session 1 B180–B208

246 B180 Patient Variability in Neurogenic 254 B188 The Pathway of Nuclear Fusion 264 B198 Munc Proteins Help Regulate Cell Differentiation of Human Amniotic Fluid during Yeast Mating. P. Melloy,1 S. Shen,1 E. Airway Mucous Secretion. B. L. Scott, Y. M. Multipotent Stem Cells. L. J. Sciorra,1,2 A. White,2 R. McIntosh,2 M. D. Rose1; 1Molecular Petrova, M. Tuvim, B. F. Dickey; Pulmonary Arriola,1 B. Bista,1 K. Gryte,1 F. Desposito3; Biology, Princeton University, Princeton, NJ, 2MCD Medicine, M.D. Anderson Cancer Center, Houston, 1Department of Biology, Saint Peter's College, Biology, University of Colorado at Boulder, Boulder, TX Jersey City, NJ, 2Obstetrics, Gynecology and CO Reproductive Sciences, UMDNJ–Robert Wood 265 B199 Munc13-1, an Active Zone Johnson Medical School, New Brunswick, NJ, 255 B189 NSF Is a Molecular Motor. W. J. Protein, Regulates Exocytosis Positively in 1 1 1 3Department of Pediatrics-Institute of Human and Cho, B. P. Jena; Physiology, Wayne State Mast Cells. N. Hirashima, K. Miura, H. Nomura, 2 1 Molecular Genetics, UMDNJ–New Jersey Medical University School of Medicine, Detroit, MI M. Nakanishi ; Graduate School of Pharmaceutical School, Newark, NJ Sciences, Nagoya City University, Nagoya, Japan, 256 B190 Neuronal Porosome Assembly 2School of Pharmacy, Aichi Gakuin University, 1 247 B181 Therapeutic Effect of Hepatocyte Requires Cholesterol in Membrane. W. J. Cho, Nagoya, Japan 1 2 2 1 Growth Factor-secreting Mesenchymal Stem A. Jeremic, H. Jin, G. Ren, B. P. Jena ; 1 Cell in Established Rat Liver Fibrosis Model. M. Physiology, Wayne State University School of 266 B200 Exo70 Interacts with 2 Kim,1,2 S. Kim,3 H. Cha,1 S. Jang,1,2 D. Chang,3 J. Medicine, Detroit, MI, Biochemistry and and Mediates the Targeting of Yang,1 B. Park,4 J. Yoon,4 W. Kim,5 H. Suh-Kim,3 Biophysics, University of California, San Francisco, the Exocyst to the Plasma Membrane. B. He, F. J. Lee1,2; 1Biochemistry and Molecular Biology, San Francisco, CA Xi, X. Zhang, J. Zhang, W. Guo; Biology, University of Pennsylvania, Philadelphia, PA Ajou University School of Medicine, Suwon, 257 B191 Exploring the Roles of Specific 2Dept. of Molecular Science and Republic of Korea, Phospholipids in Fast Calcium-triggered 267 B201 Phosphatidylinositol 4, 5- Technology, Ajou University, Suwon, Republic of Membrane Fusion. T. Rogasevskaia, M. A. bisphosphate Mediates the Targeting of the Korea, 3Dept. of Anatomy, Ajou University School Churchward, J. R. Coorssen; Physiology & Exocyst to the Plasma Membrane for of Medicine, Suwon, Republic of Korea, 4Dept. of Biophysics, University of Calgary, Hotchkiss Brain Exocytosis in Mammalian Cells. J. Liu, X. Zuo, P. Nuclear Medicine, Ajou University School of Institute, Calgary, AB, Canada Yue, W. Guo; Biology, University of Pennsylvania, Medicine, Suwon, Republic of Korea, 5Dept. of Philadelphia, PA General Surgery, Ajou University School of Medicine, Suwon, Republic of Korea Caveolae 268 B202 Elucidation of the Function of the Exocyst Protein Sec6p. M. Munson, J. A. 248 B182 In Vitro Modelling of the Saporita; Biochemistry & Molecular Pharmacology, Recovery Potential of Human Corneal Epithelial 258 B192 Tubular Localization of Over- University of Massachusetts Medical School, Cells. C. Chang, C. R. Green, C. N. J. McGhee, T. expressed Caveolin-1 in Breast Cancer Cells. P. Worcester, MA Sherwin; Ophthalmology, University of Auckland, Verma, A. Ostermeyer-Fay, D. Brown; Department of Biochemistry and Cell Biology, Stony Brook Auckland, New Zealand 269 B203 ARF6-regulated Release of University, Stony Brook, NY Ectosomes. V. M. Chari,1 G. Raposo,2 C. 1 1 Membrane Fusion 259 B193 Coordinate Regulation of D'Souza-Schorey ; Biological Sciences, University Caveolin-1 Expression by Cavin (PTRF): of Notre Dame, Notre Dame, IN, 2Institut Curie, Possible Role in Caveolae Structure/Function. Paris, France 249 B183 Regulation and Species-specific L. Liu, P. Pilch; Biochemistry, Boston University, Function of the Cellular Fusogen EFF-1. J. H. 270 B204 Membrane Fusion between Boston, MA Shinn-Thomas,1 J. J. del Campo,1,2 M. R. Schiller,3 Liposomes Containing SNARE Proteins W. A. Mohler1; 1Department of Genetics and 260 B194 Filamin A - Phospho-Caveolin-1 Involved in Exocytosis of Mast Cells. S. Developmental Biology, University of Connecticut Interaction Promotes Caveolae-mediated Tadokoro,1 H. Sakiyama,1 M. Sasai,1 M. Health Center, Farmington, CT, 2Department of Endocytosis in Endothelial Cells. M. Sverdlov, R. Nakanishi,2 N. Hirashima1; 1Nagoya City University, Pathology, Yale University of Medicine, New D. Minshall; Pharmacology, University of Illinois at Nagoya City, Japan, 2Aichi Gakuin University, Haven, CT, 3Department of Neuroscience, Chicago, Chicago, IL Nagoya City, Japan University of Connecticut Health Center, Farmington, CT 261 B195 Intersectin-2L Is a Negative 271 B205 VAMP4 Regulates MMP9 Regulator of Caveolae Endocytosis in Secretion in Breast Cancer Cells. J. Jing,1 L. 250 B184 Investigating the Mechanism of Endothelial Cells. I. K. Klein, S. A. Predescu, D. Ma,1 D. Gordon,2 A. Peden,2 R. Prekeris1; 1Cell Dynamic EFF-1 Localization in the Developing N. Predescu, A. B. Malik; Pharmacology, University and Development Biology, University of Colorado Epidermis of Caenorhabditis elegans. J. B. of Illinois–Chicago, Chicago, IL Health Science Center, Aurora, CO, 2Cambridge O'Donnell, W. A. Mohler; Genetics and Institute for Medical Research, Cambridge, United Developmental Biology, University of Connecticut 262 B196 Caveolin-1 Regulation of Cholera Kingdom Health Center, Middletown, CT Toxin b Endocytosis to the Golgi Apparatus Is Independent of Caveolae. P. Lajoie,1 S. Nim,2 J. 272 B206 Exocrine Pancreatic Secretion 251 B185 Blood-derived Small-Size Stem W. Dennis,3 I. R. Nabi1; 1Cellular and Physiological and Effects on SNARE Components by Cells Differentiate through Fusion. W. Kong, S. Sciences, University of British Columbia, Scorpion Venom. P. L. Fletcher,1 M. D. Fletcher,1 Li, H. Lorenz; Surgery, Stanford University, Vancouver, BC, Canada, 2Pharmacologie, K. Weninger,2 T. E. Anderson,2 B. M. Martin3; Stanford, CA Université de Montréal, Montreal, PQ, Canada, 1Microbiology and Immunology, Brody School of 3Samuel Lunenfeld Research Institute/University of Medicine, Greenville, NC, 2Physics, North Carolina 252 B186 Examination of the Interplay Toronto, Toronto, ON, Canada State University, Raleigh, NC, 3National Institute of between the Yeast Phospholipase D Spo14p Mental Health, National Institutes of Health, and the Syntaxin Sso1p during Sporulation. R. Bethesda, MD Mendonsa, J. Engebrecht; Section of Molecular Exocytosis: Plasma Membrane Events and Cellular Biology, University of California, Davis, 273 B207 A Role for Endocytosis in Plasma 1 1 Davis, CA 263 B197 Using Evanescent Wave Membrane Repair. V. Idone, C. C. Tam, J. 2 2 2 3 Microscopy to Distinguish Exocytic Vesicles Goss, D. Toomre, M. Pypaert, N. W. Andrews ; 253 B187 FIP200 Is Required for 1 Undergoing Fusion and Lysis. J. K. Jaiswal,1 M. Section of Microbial Pathogenesis, Yale University Autophagosome Formation and Proper 2 Fix,1 T. Takano,2 M. Nedergaard,2 S. M. Simon1; School of Medicine, New Haven, CT, Department Function of ULK. H. Taichi,1 A. Takamura,1 S. 1Laboratory of Cellular Biophysics, The Rockefeller of Cell Biology, Yale University School of Medicine, 2 2 3 1,4 3 Iemura, T. Natsume, J. Guan, N. Mizushima ; 2 New Haven, CT, Section of Microbial 1 University, New York, NY, Center for Aging and Department of Cell Physiology, Tokyo Medical and Pathogenesis and Department of Cell Biology, Yale 2 Developmental Biology, University of Rochester Dental University, Tokyo, Japan, Biological University School of Medicine, New Haven, CT Information Research Center, National Institutes of Medical Center, Rochester, NY Advanced Industrial Science and Technology, 274 B208 Rabs 8A and 14, but Not Rab8B Tokyo, Japan, 3Life Sciences Institute, University of Are Required for GLUT4 Translocation in L6 Michigan, Ann Arbor, MI, 4SORST, Japan Science Muscle Cells. S. Ishikura, P. Bilan, A. Klip; and Technology Agency, Kawaguchi, Japan Program in Cell Biology, The Hospital for Sick Children, Toronto, ON, Canada

61 SUNDAY The American Society for Cell Biology 47th Annual Meeting Poster Session 1 B209–B237 December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org

Membrane Receptors 285 B219 A Single Leucine in the First 295 B229 Endocytic Pathway Selection by Intracellular Loop Is Required for Export from MHC Proteins Correlates with Their Preference the Endoplasmic Reticulum of G Protein- for Distinct Membrane Domains. R. Knorr, C. 275 B209 Localization of Melanin- coupled Receptors. M. Duvernay, G. Wu; Karacsonyi, R. Lindner; Cell Biology, Hannover concentrating Hormone Receptor-1 to Caveolar Pharmacology, Louisiana State University Health Medical School, Hannover, Germany Membranes. E. B. Delorme,1 K. Robinson,2 L. B. 1 1 Sciences Center, New Orleans, LA Cook ; Biological Sciences, SUNY College at 296 B230 Co-regulation of Caveolar and 2 Brockport, Brockport, NY, Chemistry, SUNY 286 B220 Arrestin-2 Interacts with the E3 Fluid-Phase Endocytosis by Phospho-caveolin- College at Brockport, Brockport, NY Ubiquitin Ligase AIP4 and Mediates Endosomal 1. Z. Cheng, R. Singh, E. L. Holicky, C. L. Sorting of the Chemokine Receptor CXCR4. D. Wheatley, D. L. Marks, R. E. Pagano; Biochemistry 276 B210 Ginsenoside Rh2 Induces Bhandari,1 J. Trejo,2 J. L. Benovic,3 A. Marchese4; and Molecular Biology, Mayo Clinic College of Alteration of Lipid Rafts and Apoptosis through 1Program in Molecular Biology, Loyola University Medicine, Rochester, MN Death Receptor Pathways and Mitochondrial Chicago, Maywood, IL, 2Pharmacology, University Pathways in Human Epidermoid Carcinoma of North Carolina, Chapel Hill, NC, 3Biochemistry 297 B231 Eps15 Is Present on Early A431 Cells. E. Park; National Cancer Center, and Molecular Biology, Thomas Jefferson Endocytic Structures Following Clathrin- Goyang-si, Republic of Korea University, Philadelphia, PA, 4Pharmacology and independent Internalization of Ubiquitinated ErbB2. A. L. Gucwa, D. A. Brown; Department of 277 B211 Cholesterol Levels Regulates HIF- Program in Molecular Biology, Loyola University Biochemistry and Cell Biology, Stony Brook 1 Alpha Expression via EGFR Activation. S. Chicago, Maywood, IL University, Stony Brook, NY Lee; National Cancer Center, Goyang-si, Republic 287 B221 Cannabinoid Signaling and of Korea Stress Markers in the Conjunctival Epithelium. 298 B232 Regulation of Echovirus 1 Entry 1 M. Iribarne,1 V. Torbidoni,1 M. Castaneda,1 J. on the Plasma Membrane. E. Kakkonen, P. 278 B212 Dimerization of Scavenger 2 1 1 2 Prestifilippo,2 V. Rettori,2 A. Berra,3 A. Suburo1; Liberali, M. Karjalainen, P. Upla, D. Corda, A. Receptor Class B, Type I (SR-BI): Implication for 2 1 1 1 Luini, V. Marjomäki ; Department of Biological a Role in Selective Cholesteryl Esters (CEs) Facultad de Ciencias Biomédicas - UA, Pilar, 1 1 1 Argentina, 2CONICET, CEFYBO, Buenos Aires, and Environmental Science, University of Transport. Z. Zhang, Y. Cortez, A. Nomoto, W. 2 3 Jyväskylä, Jyväskylä, Finland, Laboratory of Cell Shen,1 E. Reaven,1 S. Azhar2; 1GRECC, VA Palo Argentina, Facultad de Medicina- UBA, Buenos Regulation, Department of Cell Biology and Alto Health CARE System and Stanford School of Aires, Argentina Oncology, Consorzio Mario Negri Sud, Santa Maria Medicine, Palo Alto, CA, 2GRECC, VA Palo Alto 288 B222 Conformational Regulation of Imbaro, Italy Health CARE System, Palo Alto, CA Plasminogen Binding to the Cation-independent 299 B233 Regulatory Role of Ligand 279 B213 Distribution and Lateral Mobility Mannose 6-Phosphate Receptor. R. N. Geometry in Classical and Non-Classical of DC-SIGN on Immature Dendritic Cells. A. Bohnsack, S. S. Twining, N. M. Dahms; Endocytosis in Endothelial Cells. C. Garnacho,1 Neumann, K. Jacobson; Cell & Developmental Biochemistry, Medical College of Wisconsin, J. Leferovich,2 C. Gajewski,2 V. Muzykantov,1 S. Biology, University of North Carolina at Chapel Hill, Milwaukee, WI Muro1; 1Pharmacology, Environmental Medicine, Chapel Hill, NC 289 B223 Paramecium tetraurelia Institute for Translational Medicine and 280 B214 Cytoskeletal Protein 4.1R Chemoreceptors for Folate and Glutamate. J. Therapeutics, University of Pennsylvania Medical Negatively Regulates Fc␧RI-mediated Mast Cell Van Houten, C. Jacobs, S. Weeraratne, J. Yano, School, Philadelphia, PA, 2Environmental Medicine, Activation. M. A. Salomao,1 P. Gascard,2 E. Ito,2 M. Valentine, H. Pantel; Biology, University of University of Pennsylvania Medical School, Y. Takakuwa,3 N. Mohandas,1 X. An1; 1Red Cell Vermont, Burlington, VT Philadelphia, PA Physiology Laboratory, New York Blood Center, 290 B224 Characterization of a Novel 300 B234 Illuminating the Phagocytic New York, NY, 2Life Sciences Division, University Polyclonal Antibody against the C-type Pathway of Dictyostelium through High of California, Lawrence Berkeley National Natriuretic Peptide Receptor. A. A. Alli,1,2,3 B. Z. Resolution Light Microscopy of Living Cells. M. Laboratory, Berkeley, CA, 3Department of McCormick,1 W. R. Gower1,2,3; 1Molecular Clarke,1 U. Engel,2 G. Gerisch3; 1Molecular, Cell, Biochemistry, Tokyo Women’s Medical University, Medicine, University of South Florida, Tampa, FL, and Developmental Biology, Oklahoma Medical Tokyo, Japan 2James A. Haley Veterans Medical Center, Tampa, Research Foundation, Oklahoma City, OK, 2Nikon 281 B215 Proteolysis of Glycoprotein IIb in FL, 3University of South Florida Cardiac Hormone Imaging Center, University of Heidelberg, EDTA-treated Platelets. W. Kenneth, Y. Ma; Center, Tampa, FL Heidelberg, Germany, 3Arbeitsgruppe Zelldynamik, Research and Development, Canadian Blood Max-Planck-Institut für Biochemie, Martinsried, 291 B225 Membrane Targeting of Arrestins Services, Edmonton, AB, Canada Germany and Signaling. M. J. Garcia Leon, M. A. Garcia 282 B216 Regulation of Growth Hormone Lopez, T. Fischer; Department of Immunology and 301 B235 Mast Cells Deficient in Receptor. L. Deng, S. Frank; University of Oncology, Centro Nacional de Biotecnologia–CSIC, Gangliosides Derived from GD1b Display Alabama at Birmingham, Birmingham, AL Madrid, Spain Endocytic Defects. V. M. Mazucato, A. M. M. Silveira e Souza, M. Jamur, C. Oliver; Cell and 283 B217 Elucidation of Regulatory Molecular Biology, Faculdade de Medicina de Mechanisms of Parathyroid Hormone Receptor- Endocytosis I Ribeirão Preto - USP, Ribeirão Preto, SP, Brazil mediated ERK1/2 Phosphorylation by Major Vault Protein. M. Saito,1,2 S. Goto,1 M. Iwashita,1 292 B226 A Novel Endocytosis Assay for 302 B236 Amiloride, an Inhibitor of Na+/H+ T. Yanagisawa,3 J. Sukegawa,3 N. Nakahata1,2; Yeast Using pH-sensitive Fluorescent Proteins. Exchanger 1 (NHE1), Prevents 1Department of Cellular Signaling, Graduate School W. J. Gostic, S. Johnson, B. Wendland; Macropinocytosis by Lowering Cytosolic pH. M. of Pharmaceutical Sciences, Tohoku University, Department of Biology, Johns Hopkins University, A. Koivusalo, H. Hayashi, T. Alexander, N. Touret, Sendai, Japan, 2Tohoku University International Baltimore, MD S. Grinstein; Program in Cell Biology, Hospital for Advanced Research and Education Organization, Sick Children, Toronto, ON, Canada Institute for International Advanced Interdisciplinary 293 B227 Observing Endocytosis in the 1 303 B237 Macropinosome Formation Research, Sendai, Japan, 3Department of Budding Yeast Pichia pastoris. S. D. Rowland, 2 1 Consists of Two Steps, Coordinately Regulated Molecular Pharmacology, Tohoku University P. L. Connerly ; Biology, Indiana University East, 2 by Phosphoinositides and Small GTPases. S. Graduate School of Medicine, Sendai, Japan Richmond, IN, Biology, Indiana University Southeast, New Albany, IN Yoshida, J. A. Swanson; Microbiology and 284 B218 Constitutive Trafficking of G- Immunology, University of Michigan Medical Protein Coupled Receptors. M. Scarselli, J. G. 294 B228 Endocytosis of Fluorescent School, Ann Arbor, MI Donaldson; NHLBI, NIH, Bethesda, MD Probes in the Submandibular Salivary Glands of Living Rodents: An Intra-vital Two-Photon Microscopy Study. A. Masedunskas, R. Weigert; OPCB/NIDCR, National Institutes of Health, Bethesda, MD

62 The American Society for Cell Biology 47th Annual Meeting SUNDAY December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org Poster Session 1 B238–B267

304 B238 The Clathrin-Independent 314 B249 Matrix Stiffness Differentially 323 B258 Arf6 Restricts Rac Signaling to Endocytic Pathway as a Novel Platform for H- Regulates Jun Kinase and SMRT to Modulate Promote Cell Survival in the 3rd Dimension. I. Ras Trafficking and Signaling. N. Porat-Shliom,1 the Apoptosis Responsiveness of a 3D Kang,1 J. Friedland,2 J. Lakins,1 W. Liu,2 J. Y. Kloog,2 J. Donaldson1; 1NHLBI/LCB, National Mammary Epithelium. M. E. Werner,1 N. Zahir,2 Chernoff,2 M. Schwartz,3 C. Chen,2 D. Boettiger,2 Institutes of Health, Bethesda, MD, 2Department of K. Tsai,1 C. Chatterjee,2 J. N. Lakins,1 V. M. V. Weaver1; 1Surgery, University of California, San Neurobiochemistry, Tel-Aviv University, Tel-Aviv, Weaver1; 1Department of Surgery, University of Francisco, CA, 2Institute for Medicine and Israel California, San Francisco, San Francisco, CA, Engineering, University of Pennsylvania, 2University of Pennsylvania, Philadelphia, PA Philadelphia, PA, 3Biochemistry, University of 305 B239 NBD-conjugated Biosurfactant Virginia, Charlottesville, VA (MEL-A) Shows a New Pathway for Gene 315 B250 Comparison of Gene Expression Transfection. Y. Inoh,1 Y. Ueno,2 T. Furuno,1 N. Differences between Endothelial Cells Grown 324 B259 Rapid Wound Healing Response Hirashima,2 M. Nakanishi1; 1Aichi Gakuin on Flat and Nanopatterned Surfaces. J. Z. in the Ctenophore Mnemiopsis leidyi. M. B. University, Nagoya, Japan, 2Nagoya City University, Gasiorowski,1 P. Russell,1 S. J. Liliensiek,1 D. A. Dodson, A. Moss; Biological Sciences, Auburn Nagoya, Japan Stephan,2 P. F. Nealey,3 C. J. Murphy1; 1Surgical University, Auburn, AL Sciences, University of Wisconsin, Madison, WI, 306 B240 Identification of EGF Receptor C- 2Neurogenomics Division, TGen, Phoenix, AZ, 325 B260 Stromal Effects on Rat Ventral terminal Sequences 1005-1017 and Di-leucine 3Chemical and Biological Engineering, University of Prostate Remodeling after Castration: Motif 1010LL1011 as Essential in EGF Receptor Wisconsin, Madison, WI Identification of a Second Apoptotic Wave. A. B. Endocytosis. Q. Wang, F. Zhu, Z. Wang; Cardoso, H. Pravatta, T. M. Augusto, H. F. Department of Cell Biology, University of Alberta, 316 B251 Tensed Stem Cells Molecularly Carvalho; Cell Biology, State University of Edmonton, AB, Canada Mapped by Cys Shotgun Labeling. B. C. Chase,1 Campinas, Campinas - SP, Brazil F. Rehfeldt,2 C. Johnson,3 D. Speicher,4 D. E. Discher5; 1Bioengineering, University of 326 B261 Secretion of Type I Collagen and Extracellular Matrix and Cell Behavior Pennsylvania, Philadelphia, PA, 2Physics, Tenascin Is Modulated by Laminin-111 in 3D University of Pennsylvania, Philadelphia, PA, Culture of Human Adenoid Cystic Carcinoma 307 B242 Distinct Patterns of Fibroblast 3Institute of Medicine and Engineering, University Cells. R. G. Jaeger, N. Scarabotto-Neto, N. Spreading, Migration, and Aggregation in the of Pennsylvania, Philadelphia, PA, 4Wistar Institute, Azambuja Jr., V. M. Freitas; Department of Cellular Four Quadrants of Cell Mechanics. S. Rhee, F. Philadelphia, PA, 5Chemical Engineering, University and Developmental Biology, Institute of Biomedical Grinnell; UT Southwestern Medical Center, Dallas, of Pennsylvania, Philadelphia, PA Sciences, Sao Paulo, Brazil TX 317 B252 Biophysical Regulation of the 327 B262 Adhesion and Protease Activity 308 B243 A Cellular Automaton Model of Breast Tumor Modulator HoxA9 through in Cell Lines from Human Salivary Gland Invadopodia-ECM Interactions. N. R. Alexander,1 Integrin-mediated Adhesion. J. K. Mouw,1 P. M. Tumors Are Regulated by the Laminin-derived 2 1 3 ␤ H. Enderling, E. Clark, A. R. A. Anderson, A. M. Gilbert,1,2 M. K. Gbegnon,2 J. N. Lakins,1 V. M. Peptide AG73, Syndecan-1 and 1 Integrin. E. Weaver1; 1Cancer Biology, Vanderbilt University, Weaver1; 1Department of Surgery, University of C. Oliveira, L. N. Gama-de-Souza, V. M. Freitas, E. Nashville, TN, 2Center for Cancer Systems Biology, California San Francisco, San Francisco, CA, S. Melo, V. F. Vilas-Boas, A. S. Moriscot, R. G. Tufts University, Boston, MA, 3Mathematics, 2University of Pennsylvania, Philadelphia, PA Jaeger; Department of Cellular and Developmental University of Dundee, Dundee, United Kingdom Biology, Institute of Biomedical Sciences, University 318 B253 Protein Kinase C ␧ Is Required of Sao Paulo, Sao Paulo, Brazil 309 B244 An Experimental Model for for Cutaneous Wound Closure and Assessing Corneal Fibroblast Migration in 3D Formation. A. Leask,1 X. Shi-wen,2 328 B263 Tenascin-C May Regulate Cell Collagen Matrices. D. Karamichos, N. Lakshman, C. Black,2 D. Abraham2; 1University of Western Behavior during Coronary Vasculogenesis. K. 1 2 1 W. M. Petroll; Ophthalmology, UT Southwestern, Ontario, London, ON, Canada, 2University College Imanaka-Yoshida, S. Miyagawa-Tomita, M. Hara, 1 1 1 Dallas, TX London, London, United Kingdom M. Namikata, T. Yoshida ; Pathology, Mie University, Tsu, Japan, 2Pediatric Cardiology, Tokyo 310 B245 Easily Fabricated Robust and 319 B254 Prostatic Smooth Muscle Cell Women's Medical University, Tokyo, Japan Reproducible Extracellular Matrix of Collagen Phenotype Is Modulated by Extracellular Matrix Fibrils. A. L. Plant,1 K. Bhadriraju,1 J. T. Components. E. Antonioli, S. B. Pimentel, F. 329 B264 Extracellular Matrix-mediated Woodward,2 J. T. Elliott1; 1Biochemical Science, Kühne, A. B. Cardoso, H. F. Carvalho; Cell Biology, Localization of Kir4.1 and AQP4 in the NIST, Gaithersburg, MD, 2Optical Technology, State University of Campinas, Campinas - SP, Basolateral Domain of MDCK Cells. D. Tham, H. NIST, Gaithersburg, MD Brazil Moukhles; Cellular and Physiological Sciences, The University of British Columbia, Vancouver, BC, 311 B246 Analyses of the Functional 320 B255 Biodegradable Dextran Matrices Canada Significance of Fibrillar vs. Non-Fibrillar for Cell Culture and Tissue Engineering Fibronectin Matrices in Xenopus laevis Applications. M. H. Lee,1 R. J. Composto,2 D. 330 B265 Prostatic Ducts and Acini with Embryos. T. Rozario,1 B. Dzamba,1 L. Davidson,2 Boettiger3; 1Institute for Medicine & Engineering, and without Focal Disruptions in the Basal Cell D. W. DeSimone1; 1Cell Biology, University of University of Pennsylvania, Philadelphia, PA, Layer Have Different Gene Expression Profiles: Virginia, Charlottesville, VA, 2School of 2Materials Science & Engineering, University of Implications for Tumor Progression and 1 2 1 Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania, Philadelphia, PA, 3Microbiology, Invasion. A. Liu, Y. Man ; Department of PA University of Pennsylvania, Philadelphia, PA Pathology, 301 Hospital, Beijing, China, 2Gynecologic and Breast Pathology, American 312 B247 Matrix Elasticity Guided 321 B256 Electrospun Polyamide Registry of Pathology and Armed Forces Institute Myogenesis of Mesenchymal Stem Cells. F. Nanofibers Support Expansion and of Pathology, Washington, DC Rehfeldt,1 T. Chaudhuri,2 S. Cai,1 A. J. Engler,1 H. Differentiation of Mesenchymal Stem Cells. S. L. Sweeney,2 D. E. Discher1; 1Biophysical M. Larkin,1 M. Sievert,1 M. W. Briggs,2 J. J. Ross1; Engineering Lab, University of Pennsylvania, 1In Vitro Technologies, SurModics, Inc., Eden Cell-Cell Adherens Junctions Philadelphia, PA, 2Pennsylvania Muscle Institute, Prairie, MN, 2Technical Applications, Corning Life University of Pennsylvania, Philadelphia, PA Sciences, Kennebunk, ME 331 B266 Rap1 in Drosophila Morphogenesis. N. J. Harris, J. K. Sawyer, M. 313 B248 Measuring Cellular Contractility 322 B257 FGF-2 Covalently Bound to Peifer; University of North Carolina at Chapel Hill, in Micropatterned 3-D Cultures. W. R. Legant, N. Polyamide Nanofibrillar Surfaces Demonstrates Chapel Hill, NC J. Sniadecki, S. Raghavan, C. S. Chen; Enhanced Biological Activity and Stability. S. Bioengineering, University of Pennsylvania, Meiners; Pharmacology, UMDNJ–Robert Wood 332 B267 Diaphanous, a Regulator of Philadelphia, PA Johnson Medical School, Piscataway, NJ Adhesion and Cell Shape. C. F. Homem, M. Peifer; Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC

63 SUNDAY The American Society for Cell Biology 47th Annual Meeting Poster Session 1 B268–B299 December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org

333 B268 Cdc42 Regulates Adherens 344 B279 Bacterial Lipopolysaccharide 353 B288 p120-catenin Is Required for Junctions and Epithelial Cell Polarity during (LPS) Increases Tyrosine Phosphorylation of Mouse Vascular Development. R. G. Oas,1 K. Drosophila Development. K. P. Harris, U. Tepass; Zonula Adherens (ZA) Proteins and Opens the Xiao,1 S. Summers,1 C. M. Chiasson,1 W. D. Cell and Systems Biology, University of Toronto, Paracellular Pathway in Lung Microvascular Martin,2 H. E. Grossniklaus,3 A. B. Reynolds,4 A. P. Toronto, ON, Canada Endothelia through TLR4, TRAF6, and Src Kowalczyk1; 1Department of Cell Biology, Emory Family Kinase (SFK) Activation. P. Gong,1 S. University, Atlanta, GA, 2Transgenic Mouse Core ␤ 334 B269 Local -actin Translation Is Yang,1 D. Mann,1 D. D. Bannerman,2 S. N. Vogel,3 Facility, Emory University, Atlanta, GA, Required for Adherens Junction Formation. A. S. E. Goldblum1; 1Medicine and Pathology, 3Department of Ophthalmology, Emory University, J. Rodriguez, S. M. Shailesh, S. Burke, J. Mucosal Biology Research Center, University of Atlanta, GA, 4Department of Cancer Biology, Condeelis, R. H. Singer; Anatomy and Structural Maryland, Baltimore, Baltimore, MD, 2USDA, Vanderbilt University, Nashville, TN Biology, Albert Einstein College of Medicine, Bronx, Bovine Functional Genomics Laboratory, Beltsville, NY MD, 3Microbiology, Mucosal Biology Research 354 B289 Novel Intermediate Filament- ␥ Center, University of Maryland, Baltimore, linked N-cadherin/ -Catenin Complex Involved 335 B270 Role of Actin Remodeling and Baltimore, MD in Establishment of Differentiated Tissue Cellular Contraction in Adherens Junction Architecture. M. Leonard, A. S. Menko; Pathology Dissolution. R. Sperry, R. Vellinga, M. D. H. 345 B280 Freeze Fracture Studies of Tight Anatomy and Cell Biology, Thomas Jefferson Hansen; Physiology and Developmental Biology, Junctions in Mouse Submandibular Gland and University, Philadelphia, PA Brigham Young University, Provo, UT Cultured Salivary Gland Cells. K. Kikuchi,1 S. Aiyama,1 J. Kawedia,2 A. Menon,2 A. R. Hand3; 355 B290 N-cadherin/p120 Catenin 336 B271 Perturbing the Localization of 1Department of Histology, The Nippon Dental Association at Cell-Cell Contacts Occurs in Alpha-catenin: Effects on Membrane Dynamics University School of Life Dentistry at Tokyo, Tokyo, Lipid Rafts and Is Required for RhoA Activation Independent of Cell-Cell Adhesion. J. Benjamin, 1 Japan, 2Department of Molecular Genetics, and Myogenesis Induction. N. Taulet, F. W. J. Nelson; Biological Sciences and MCP, 1 1 1 2 University of Cincinnati, Cincinnati, OH, Comunale, S. Charrasse, S. Bodin, C. Favard, Stanford University, Stanford, CA 1 1 3Department of Craniofacial Sciences, University of C. Gauthier-Rouvière ; CRBM, CNRS, Montpellier, France, 2Institut Fresnel, CNRS, Marseille, France 337 B272 Zyxin Is a Regulator of HGF- Connecticut Health Center, Farmington, CT induced Cell-Cell Dissociation in MDCK Cells. 346 B281 Transcriptional Control of JAM-A 356 B291 p120-catenin Is Apparently R. Sperry, J. Bramwell, L. Keyes, B. Fowler, R. via the Interaction of Nuclear Factor-Y, Nuclear Essential for Mammary Gland Development. S. Vellinga, M. Brodeur, M. D. H. Hansen; Physiology 1 1 2 Factor-1, and GATA Proteins with NF-Y Motifs. J. Kurley, M. A. Davis, W. J. Muller, A. B. and Developmental Biology, Brigham Young 1 1 W. Lui, P. Lie, W. Lee; School of Biological Reynolds ; Department of Cancer Biology, University, Provo, UT 2 Science, The University of Hong Kong, Hong Kong Vanderbilt University, Nashville, TN, Departments of Biochemistry and Medicine, McGill University, 338 B273 Thrombospondin (TSP)-1 347 B282 Regulation of JAM-B Expression Montreal, PQ, Canada Increases Tyrosine Phosphorylation of Zonula via an Interplay of Transcription Factors of Elk- Adherens (ZA) Proteins and Regulates the 1, Sp, and E2F Families in Testicular Cells. Y. 357 B292 Localization of N-cadherin in Endothelial Paracellular Pathway through Wang, W. M. Lee, W. Y. Lui; School of Biological Skeletal Muscle Myoblasts during 3D Culture. Epidermal Growth Factor Receptor (EGFR) M. L. Marquette,1 D. Byerly,1 M. Sognier2; 1NASA 1 1 1 Sciences, The University of Hong Kong, Hong Activation. P. Garg, S. Yang, A. Liu, D. S. Johnson Space Center, Houston, TX, 2NASA 2 3 1 2 Kong Annis, M. A. Pallero, A. Passaniti, D. F. Mosher, Johnson Space Center, Universities Space 3 1 1 J. Murphy-Ullrich, S. E. Goldblum ; Medicine and 348 B283 Structural and Functional Defects Research Association, Houston, TX Pathology, Mucosal Biology Research Center, of Gastric Parietal Cells in Protein 4.1R Null University of Maryland, Baltimore, Baltimore, MD, Mice. S. Yang, G. Debnath, N. Mohandas, X. An; 358 B293 Atypical Cadherins Are Required 2 Medicine, University of Wisconsin, Madison, WI, Red Cell Physiology Lab, New York Blood Center, for Cell Movements during C. elegans 3 Pathology, University of Alabama at Birmingham, New York, NY Gastrulation. D. J. Marston, B. Goldstein; Dept. of Birmingham, AL Biology, University of North Carolina at Chapel Hill, 349 B284 Defective Actin Cytoskeletal Chapel Hill, NC 339 B274 PKC-dependent Regulation of Organization in Epithelia of Henle’s Loop of p120-catenin. M. H. Vaughan, A. B. Reynolds; Kidney in Protein 4.1R Null Mice. S. Yang,1 C. 359 B294 Cell-Cell Junctions in Nucleus Cancer Biology, Vanderbilt University, Nashville, TN Liu,1 P. Gascard,2 G. Debnath,1 N. Mohandas,1 X. and Centrosome Positioning. I. Vallois, E. 1 1 Camand, S. Etienne-Manneville; Cell Polarity and 340 B275 Src Family Kinases Play An ; Red Cell Physiology Lab, New York Blood 2Life Sciences Division, Migration, Institut Pasteur, Paris, France Essential Roles in Lens Development and Center, New York, NY, University of California Lawrence Berkeley National Disease through Modulation of Cadherin 360 B295 E-cadherin Levels in Mature Laboratory, Berkeley, CA Junctions. A. S. Menko, M. Leonard, J. L. Walker; Adherens Junctions Are Dynamically Adjusted Pathology, Anatomy and Cell Biology, Thomas 350 B285 Male Infertility Due to Defective by Endocytosis and Not by Lateral Diffusion. S. Jefferson University, Philadelphia, PA Spermatogenesis in Protein 4.1G Knockout de Beco, C. Gueudry, F. Amblard, S. Coscoy; UMR 1 M. Parra,2 J. Conboy,2 G. 168, Institut Curie, Paris, France 341 B276 The Role of PTP-MEG1 in Mice. S. Yang, Debnath,1 N. Mohandas,1 X. An1; 1Red Cell Mammary Epithelial Cell Morphogenesis. K. R. 361 B296 Cadherin-11 Interacts with the Physiology Lab, New York Blood Center, New Johnson,1 J. N. Lakins,2 S. Desai,2 V. M. Weaver2; FGF Receptor and Induces Neurite Outgrowth York, NY, 2Life Sciences Division, Lawrence 1Bioengineering, University of Pennsylvania, through Associated Downstream Signalling. C. Berkeley National Laboratory, Berkeley, CA Philadelphia, PA, 2Surgery, University of California, Boscher,1,2 R. Mège1,2; 1Institut du Fer à Moulin, San Francisco, San Francisco, CA INSERM, Paris, France, 2Université Pierre et Marie Cadherins Curie, Paris, France 342 B277 A Novel Ras Activator, RasGRP3, Is Involved in Disruption of Endothelial 362 B297 Involvement of Cadherins/ Adherens Junctions. P. K. Randhawa,1 D. M. 351 B286 Molecular Details of p120 GTPases Signaling Pathway during Myoblast Roberts,1 W. Dunworth,2 A. Anderson,1 V. L. Interactions in the E-cadherin/Catenin Complex Fusion. S. Charrasse, F. Comunale, C. Gauthier- Bautch3; 1Biology, University of North Carolina, In Vivo and In Vitro. A. Kiss, R. Troyanovsky, S. Rouviere; CNRS, Montpellier, France Chapel Hill, NC, 2Genetics, University of North M. Troyanovsky; Dermatology, Washington Carolina, Chapel Hill, NC, 3Biology/Genetics, University Medical School, St. Louis, MO 363 B298 WITHDRAWN University of North Carolina, Chapel Hill, NC 352 B287 The Phosphorylation Domain of 364 B299 The Protein Tyrosine 343 B278 Uncovering the Mechanisms of p120 Catenin Modulates E-cadherin Dynamics Phosphatase PTP1B Is Required for Efficient 1 Epidermal Differentiation vs. Self-Renewal. S. at the Plasma Membrane. Y. Fukumoto, Y. Delivery of N-cadherin to the Cell Surface. M. V. 2 2 2 1 Lasse, C. Jamora; Biology, University of California, Shintani, K. Johnson, M. Wheelock ; Eppley Hernandez, C. O. Arregui; IIB-INTECH, University San Diego, La Jolla, CA Institute for Research in Cancer and Allied of San Martin, San Martin, Buenos Aires, Argentina Diseases, University of Nebraska Medical Center, Omaha, NE, 2Oral Biology, University of Nebraska Medical Center, Omaha, NE

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365 B300 N-cadherin Expression Levels in 375 B310 Binucleate Cells Appears in 385 B320 Structural Basis of Kinesin-5 Endothelial Cells: Regulation and Effects on Tenascin-C Knockout Mouse Prostatic Regulation. A. Gerson,1 E. R. Hildebrandt,2 T. Barrier Function. D. M. Ferreri, P. A. Vincent; Epithelium. K. Ishii,1 K. Imanaka-Yoshida,2 H. Kingsbury,2 S. Lakämper,3 C. F. Schmidt,3 M. A. Center for Cardiovascular Sciences, Albany Kanda,1 Y. Ogura,1 M. Kanai,1 K. Arima,1 T. Hoyt,2 L. Gheber1; 1Clinical Biochemistry and Medical College, Albany, NY Yoshida,2 Y. Sugimura1; 1Department of Nephro- Chemistry, Ben-Gurion University, Beer-Sheva, Urologic Surgery and Andrology, Mie University Israel, 2Biology, Johns Hopkins University, 366 B301 Interplay between Src, E-cadherin Graduate School of Medicine, Tsu, Mie, Japan, Baltimore, MD, 3Drittes Physikalisches Institut, Junctions, and PI3 Kinase in the Formation of 2Department of Pathology and Matrix Biology, Mie Gottingen University, Gottingen, Germany Ductal Structures in the Developing University Graduate School of Medicine, Tsu, Mie, 1 Submandibular Gland. M. A. Kukuruzinska, J. Japan 386 B321 The BimC Coil: A Coiled Coil Walker,2 S. Khalil,1 A. Menko2; 1Department of with Conserved Amino Acid Sequence and Molecular and Cell Biology, Boston University 376 B311 GSK3 Phospholylates ␦-catenin Function in Spindle Organization. P. G. School of Dental Medicine, Boston, MA, and Affects Its Stability. M. Oh,1 H. Kim,1 S. Wilson,1,2 S. Huang,1 J. Howell1; 1Georgia State 2Department of Anatomy, Pathology and Cell Bareiss,2 Q. Lu,2 K. Kwonseop1; 1Chonnam University, Atlanta, GA, 2University of Georgia, Biology, Thomas Jefferson University, Philadelphia, National University, Gwangju, Republic of Korea, Athens, GA PA 2The Brody School of Medicine at East Carolina University, Greenville, NC 387 B322 Dimeric and Tetrameric Eg5 367 B302 Rac1 Regulation by p120-catenin Motility on Single and Paired Microtubules. H. T. in HaCat Cells. A. L. Smith, A. B. Reynolds; 377 B312 Biomaterials-directed In Vivo Schek, M. Uteng, T. Surrey; EMBL, Heidelberg, Cancer Biology, Vanderbilt University Medical Commitment of Mesenchymal Cells Derived Germany Center, Nashville, TN from Human Embryonic Stem Cells. N. S. Hwang, S. Varghese, J. Elisseeff; Biomedical 388 B323 Stepping Dynamics of Kinesin 368 B303 p120 Has Two Binding Sites to Engineering, Johns Hopkins University, Baltimore, Motor on the Surface of Microtubule. C. Hyeon, RhoA. M. Yanagisawa, P. Anastasiadis; Mayo MD J. N. Onuchic; Center for Theoretical Biological Clinic, Jacksonville, FL Physics, University of California, San Diego, La 378 B313 MT2-MMP Regulates Epithelial Jolla, CA 369 B304 EGFR and Matrix Morphogenesis and Collagen-IV Expression Metalloproteinases Differentially Regulate during Mouse Submandibular Gland 389 B324 Illuminating Kinesin-1's Stepping Internalization of Classic and Desmosomal Development. I. T. Rebustini,1 C. Myers,1 A. Mechanism with FRET between the Motor Cadherins in Squamous Cell Carcinoma Cells. Surmak,2 L. Szabova,2 K. Lassiter,1 K. Holmbeck,1 Domains. Z. Lansky, S. Verbrugge, E. J. G. B. V. Desai, J. L. Klessner, K. J. Green; M. Hoffman1; 1LCDB, NIDCR/NIH, Bethesda, MD, Peterman; Physics & Astronomy, VU University Department of Pathology, Northwestern University, 2CSDB, NIDCR/NIH, Bethesda, MD Amsterdam, Amsterdam, The Netherlands Chicago, IL 379 B314 Renal Collecting Duct Epithelial 390 B325 Analysis of Conformational 370 B305 N-glycosylation of E-cadherin Polarization and Proliferation Require Laminin- Changes of Functional Loop L11 of Kinesin Promotes Cellular Discohesion in Oral ␥1. D. Yang,1 Z. Chen,2 S. Strickland,3 C. Bates,4 Using Electron Spin Resonance (ESR). M. D. 1 1 2 1 1 Squamous Cell Carcinoma. M. Nita-Lazar, V. K. Mckee,1 P. Yurchenco1; 1Pathology, Robert Yamada, T. Arata, K. Kondo, H. Maeda, S. 2 3 3 1 1 Noonan, J. Walker, A. Sue Menko, M. A. Wood Johnson Medical School–UMDNJ, Maruta ; Division of Bioengineering, Graduate 1 1 Kukuruzinska ; Molecular and Cell Biology, Boston Piscataway, NJ, 2Pathology, Rockefeller University, School of Engineering, Soka University, Hachioji, 2 2 University Medical Center, Boston, MA, Oral New York, NJ, 3Rockefeller University, New York, Tokyo, Japan, Department of Biological Science, Pathology, Boston University Medical Center, NY, 4Ohio State University, Columbus, OH Graduate School of Science, Osaka University, Boston, MA, 3Anatomy, Pathology and Cell Biology, Toyonaka, Osaka, Japan Thomas Jefferson University, Philadelphia, PA Kinesin I 391 B326 The Kinesin-1 Tail Regulates 371 B306 Multiple Post-translational Motor Activity through an Interaction with Modifications of E-cadherin during ER Stress Switch I. K. A. Dietrich,1 C. V. Sindelar,2 Y. L. 380 B315 Photo-Regulation of Industrial and Apoptosis. F. Geng,1 W. Zhu,1 B. Leber,2 D. Wong,1 P. Brewer,3 K. H. Downing,2 C. Cremo,3 S. Enzymes Using Photo-Responsible Caged Andrews1; 1Biochemistry and Biomedical Sciences, E. Rice1; 1Department of Cell/Molecular Biology, Compound. E. Chia, M. Yamada, H. Maeda, S. McMaster University, Hamilton, ON, Canada, Northwestern University, Chicago, IL, 2Life Maruta; Division of Bioengineering, Graduate 2Medicine, McMaster University, Hamilton, ON, Sciences Division, Lawrence Berkeley School of Engineering, Soka University, Tokyo, Canada Laboratories, Berkeley, CA, 3Biochemistry, Japan University of Nevada–Reno, Reno, NV 381 B316 Interaction of Photochromic ATP Extracellular Matrix and Morphogenesis 392 B327 Proposed Mechanism of Analogues with ATP-driven Motor Proteins. K. Regulation of Nucleotide Exchange in Kinesin/ Tanaka, M. Ito, S. Maruta; Division of Microtubule System. R. Nitta, Y. Okada, N. 372 B307 Branching Morphogenesis of Bioengineering, Graduate School of Engineering, Hirokawa; Cell Biology and Anatomy, University of Endothelial Cells Is Regulated by Myosin Soka University, Hachioji, Tokyo, Japan Contractility. R. S. Fischer,1 M. Gardel,2 C. Tokyo, Tokyo, Japan Waterman1; 1The National Heart Lung and Blood 382 B317 Monastrol and NSC 622124 393 B328 Kinesin-2 and Kinesin-1 Differ in Institute, National Institutes of Health, Bethesda, Inhibit Human Eg5 Kinesin through Different Both the Magnitude and the ATP-dependence of MD, 2University of Chicago, Chicago, IL Binding Sites. S. A. Sebring,1 N. S. Stevens,1 S. Processivity. G. Muthukrishnan, W. O. Hancock; Kim,2 E. J. Wojcik,2 R. A. Walker1; 1Biological Bioengineering, The Pennsylvania State University, 373 B308 Is Abnormal Formation and Sciences, Virginia Tech, Blacksburg, VA, University Park, PA Remodeling of Microfibrils from Type I Collagen 2Biochemistry and Molecular Biology, Louisiana Homotrimers Involved in Age-related State University Health Sciences Center, New 394 B329 Characterization of the ATPase Osteoporosis? S. Han,1,2 S. Leikin2; 1Physics, Orleans, LA Kinetic Pathway of the Novel Rice Kinesin K16. University of Maryland, College Park, MD, 2NIH, M. Tsuchida,1 Y. Masafumi,2 Y. Eiko,1 K. Kazunori,1 Bethesda, MD 383 B318 Movements of the Molecular M. Shinsaku1,2; 1Bioinformatics, Soka University, Motor Eg5 in Xenopus laevis Egg Extract Tokyo, Japan, 2Bioengineering, Graduate School of 374 B309 chongmague Reveals an Spindles. M. Uteng, C. Hentrich, T. Surrey; Cell Engineering, Soka University, Tokyo, Japan Essential Role for Laminin-mediated Boundary Biology & Biophysics, EMBL, Heidelberg, Germany Formation in Chordate Convergence and Extension Movements. M. T. Veeman, Y. 384 B319 The Effect of Monastrol on the Nakatani, C. Hendrickson, V. Ericson, C. Lin, W. C. Biophysical Behavior of Eg5/DmKHC-Chimeras. Smith; Molecular, Cell and Developmental Biology, S. Lakaemper,1 M. Korneev,2 S. Reiter,1 L. C. University of California Santa Barbara, Santa Kapitein,2 E. J. G. Peterman,2 C. F. Schmidt1; 1III. Barbara, CA Physikalisches Institut, GAU Göttingen, Göttingen, Germany, 2Physics of Complex Systems, VU Amsterdam, Amsterdam, The Netherlands

65 SUNDAY The American Society for Cell Biology 47th Annual Meeting Poster Session 1 B330–B359 December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org

395 B330 Crystallographic Study on the 404 B339 A Role for Atypical Rho GTPase 415 B350 A Genome Wide Screen for New Motor Domain of Rice Kinesin K16 Reveals a Chp in Mouse Embryonic Stem Cells Migration Regulators of and Cytokinesis in Novel Conformation of Neck-linker. S. Maruta,1 via PAK. B. Lua, E. Manser; Institute of Medical Dictyostelium discoideum. S. S. Willard,1 J. N. Umeki,2 T. Mitsui,3 Z. Fujimoto4; 1Department of Biology, Singapore Borleis,1 Y. Serafimidis,2 Q. Zhou,1 D. N. Bioinformatics, Soka University, Hachioji, Tokyo, Robinson,1 R. R. Kay,2 P. N. Devreotes1; 1Cell Japan, 2Department of Physiology, University of 405 B340 The Role of Rho1 in Bcr-Abl Biology, Johns Hopkins University School of Massachusetts Medical Center, Worcester, MA, Signaling Pathways during Cell Migration in Medicine, Baltimore, MD, 2MRC Laboratory of 3Group of Plant and Microbial Genome Controls, Drosophila melanogaster. T. L. Stevens, N. B. Molecular Biology, Cambridge, United Kingdom Niigata University Graduate School of Science and Artabazon, S. E. Tittermary, K. M. Vernier; Biology, Technology, Niigata, Japan, 4Department of Randolph–Macon College, Ashland, VA 416 B351 Screening for Protein Biochemistry, National Institute of Agrobiological Localization during Chemotaxis Using a GFP 406 B341 Resveratrol Inhibits Cell 1 1 Sciences, Tsukuba, Ibaraki, Japan Fusion Library. K. E. Franson, B. Diplas, Y. Spreading and Migration through Inactivation of Kohara,2 H. Urushihara,3 P. N. Devreotes1; 396 B331 Characterization of the Novel the PI3K/Rac1 Signaling Pathway. F. J. Ashcroft, 1Department of Cell Biology, Johns Hopkins Rice Kinesin O12. U. Nozomi,1 U. Nobuhisa,2 K. A. C. Daquinag, W. T. Chao, J. Kunz; Molecular University School of Medicine, Baltimore, MD, Kazunori,3 M. Toshiaki,4 M. Shinsaku1,3; 1Division Physiology and Biophysics, Baylor College of 2National Institute of Genetics, Mishima, Japan, of Bioengineering, Graduate School of Engineering, Medicine, Houston, TX 3Graduate School of Life and Environmental Soka University, Tokyo, Japan, 2Department of Science, University of Tsukuba, Tsukuba, Japan 407 B342 The Activation of Rac by Paxillin Physiology, University of Massachusetts Medical 3 through Multiple Independent Signaling 417 B352 Mechano-chemical Signaling School, Worcester, MA, Department of 1 2 2 Pathways. S. J. Pratt, E. M. Vogel, B. Imperiali, Maintains the Rapid Movement of Dictyostelium Bioinformatics, Faculty of Engineering, Soka A. F. Horwitz1; 1Cell Biology, University of Virginia, 4Graduate School of Cells. M. Lombardi, D. Knecht, J. Lee; Molecular University, Tokyo, Japan, Charlottesville, VA, 2Chemistry and Biology, Science and Technology, Niiga University, Niigata, and Cell Biology, University of Connecticut, Storrs, Massachusetts Institute of Technology, Cambridge, Japan CT MA 418 B353 The Lipid-binding Diaphanous- Cell Motility - Regulation I 408 B343 Type I Phosphatidylinositol related Formin ForA Regulates the Integrity of Phosphate Kinases Are Functionally Non- the Cortical Actin Cytoskeleton. N. equivalent and Regulate Cell Migration through Ramalingam,1 M. Rohlfs,1 J. Faix,2 M. Schleicher1; 397 B332 GPR56 Regulates Neural Distinct Mechanisms. W. Chao, A. C. Daquinag, 1ABI/Cell Biology, Munich, Germany, 2Department Progenitor Cell Migration through G12/13 and F. Ashcroft, J. Kunz; Molecular Physiology & of Biophysical Chemistry, Hannover Medical Rho Axis. T. Iguchi, K. Sakata, K. Yoshizaki, K. Biophysics, Baylor College of Medicine, Houston, School, Hannover, Germany Tago, N. Mizuno, H. Itoh; Department of Cell TX Biology, Nara Institute of Science and Technology, 419 B354 Quantitative Statistical Analysis Nara, Japan 409 B344 Filamin A Interacts with C- of the Chemotactic Motility Cycle of Amoeboid Terminal Tail of P2Y2 Nucleotide Receptor and Cells. R. Meili,1 J. C. del Álamo,2 B. Alonso- 398 B333 Transient Activation of the Small Regulates Smooth Muscle Cell Migration. N. Yu, Latorre,2 J. Rodríguez-Rodríguez,3 R. A. Firtel,1 J. GTPase Rap1 Is Functionally Required for the G. Weisman, C. Seye; University of C. Lasheras2; 1Section of Cell and Developmental Regulation of Cell Motile Responses to IGF-I. W. Missouri–Columbia, Columbia, MO Biology Division of Biological Sciences, University S. Y. Lee,1 N. Kushnir,1 D. K. Furstenau,2 M. J. L. of California, San Diego, La Jolla, CA, 2Department Dela Cruz,2 M. A. Guvakova3; 1Microbiology, 410 B345 Probing the Influence of Signal of Mechanical and Aerospace Engineering, University of Pennsylvania, Philadelphia, PA, Relay on Chemotaxis. E. C. Rericha,1 W. Losert,2 University of California, San Diego, La Jolla, CA, 2Surgery, University of Pennsylvania, Philadelphia, C. A. Parent3; 1University of Maryland, College 3Departamento de Ingeniería Térmica y de Fluidos, PA, 3Surgery, Microbiology, University of Park, MD, 2Department of Physics/IPST/IREAP, Universidad Carlos III de Madrid, Madrid, Spain Pennsylvania, Philadelphia, PA University of Maryland, College Park, MD, 3 Laboratory of Cellular and Molecular Biology, 420 B355 Dynamics and Role of PI3K 399 B334 Interplay between Rac1 and Rap1 National Cancer Institute, NIH, Bethesda, MD Signaling during Active Spreading of in c-Cbl-facilitated Cytoskeletal Effects in v-Abl Fibroblasts on Adhesive Surfaces. M. Weiger, J. Transformed NIH3T3 Fibroblasts. H. Lee,1 A. Y. 411 B346 Quantitative Analyses of Stream Rhoden, C. Wang, J. Haugh; North Carolina State Tsygankov1,2; 1Microbiology and Immunology, Formation during Dictyostelium Chemotaxis. C. University, Raleigh, NC Temple University School of Medicine, Philadelphia, P. McCann,1 P. W. Kriebel,1 E. C. Rericha,2 C. A. 2 1 2 1 PA, Fels Institute for Cancer Research and Parent, W. Losert ; Laboratory of Cellular and 421 B356 Linker Domain of Akt1 Is Molecular Biology, Temple University School of Molecular Biology, National Cancer Institute, NIH, Important for Targeting to the Ruffling Region 2 Medicine, Philadelphia, PA Bethesda, MD, IREAP, University of Maryland, and Cell Migration. E. Kim,1 S. Yun,1 K. Do,1 M. College Park, MD Kim,1 D. Tucker,2 C. Kim,1 M. Birnbaum,2 S. Bae3; 400 B335 Scaffold Protein Function in 1Pharmacology, Pusan National University School Crosstalk between ARF6 and Rac1. L. C. Santy; 412 B347 Dictyostelium Chemotaxis Is of Medicine, Busan, Republic of Korea, Department of Biochemistry and Molecular Biology, Regulated and Sensitized by Extracellular 2Department of Medicine, Howard Hughes Medical Pennsylvania State University, University Park, PA Signal Degradation. G. L. Garcia, C. A. Parent; 3Pharmacology, Laboratory of Cellular and Molecular Biology, Institute, Philadelphia, PA, MRCITR and Pusan National University School of 401 B336 A Rho Family GEF Regulates National Cancer Institute, NIH, Bethesda, MD Adhesion Dynamics in Migrating Cells. J. M. Medicine, Busan, Republic of Korea Bristow, D. Majumdar, D. J. Webb; Biological 413 B348 cAMP Dynamics in Chemotactic Sciences, Vanderbilt University, Nashville, TN Cells. A. Bagorda, C. A. Parent; Laboratory of Cytoskeletal Organization I Cellular and Molecular Biology, National Cancer 402 B337 Differences in the Activation Institute, NIH, Bethesda, MD Dynamics of RhoA and RhoC Revealed Using 422 B357 Kinetics of Formation of Actin Live Cell Biosensors. J. S. Zawistowski, L. 414 B349 Activation of TorC2 and PKB at Bundles. P. Kraikivski, I. L. Novak, B. M. Hodgson, G. L. Johnson, K. M. Hahn; the Cell's Leading Edge Mediates Chemotaxis. Slepchenko; University of Connecticut Health Pharmacology, University of North Carolina School Y. Kamimura, P. Devreotes; Cell Biology, Johns Center, Farmington, CT of Medicine, Chapel Hill, NC Hopkins University, School of Medicine, Baltimore, MD 423 B358 WITHDRAWN 403 B338 Spatio-Temporal Dynamics of RhoA Activation during Migration of Breast 424 B359 Loading Affects Spatial Cancer Cells. P. M. F. Siesser, L. Hodgson, K. Organization of Actin Networks. O. Chaudhuri, Hahn, R. Juliano; Pharmacology, University of S. H. Parekh, D. A. Fletcher; Bioengineering, North Carolina–Chapel Hill, Chapel Hill, NC University of California, Berkeley, Berkeley, CA

66 The American Society for Cell Biology 47th Annual Meeting SUNDAY December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org Poster Session 1 B360–B389

425 B360 Modulating Actin Network 435 B370 N-WASP Is Present at - 444 B379 Stress Fiber Organization and Mechanics with Force. S. H. Parekh, O. like Structures (Tubulobulbar Complexes) That Assembly Disruption by Cellular Titin Kinase. P. Chaudhuri, D. A. Fletcher; Bioengineering, Form at Intercellular Junctions in the Testis. A. J. Cavnar, S. Olenych, T. C. Keller; Department of University of California, Berkeley, Berkeley, CA W. Vogl,1 J. A. Guttman,2 D. C. To,1 M. Li,1 J. S. Biological Sciences, Florida State University, Young1; 1Cellular & Physiological Sciences, Tallahassee, FL 426 B361 IQGAP1 Regulates Salmonella University of British Columbia, Vancouver, BC, Invasion through Interactions with Actin, Rac1, Canada, 2Michael Smith Laboratories, University of 445 B380 mTOR and AMPK Signaling and Cdc42. M. D. Brown, L. Bry, Z. Li, D. B. British Columbia, Vancouver, BC, Canada Regulate RhoA Activity during Renal Ischemia. Sacks; Pathology, Brigham and Women's Hospital, M. A. Hallett, H. Zhang, S. J. Atkinson; Medicine, Boston, MA 436 B371 The Role of WASp in Podosome Indiana University, Indianapolis, IN Formation and Function. J. Gevrey,1 A. Dovas,1 427 B362 Linking Ras to Myosin Function: W. Abou-Kheir,1 A. Grossi,2 D. Cox1; 1Albert RasGEF Q, a Dictyostelium Exchange Factor for Einstein College of Medicine, New York, NY, Cilia and Flagella I RasB, Affects Myosin II Functions. S. Mondal, D. 2Faculty of Life Sciences, University of Bakthavatsalam, B. Gassen, F. Rivero, A. Noegel; Copenhagen, Copenhagen, Denmark 446 B381 Evolution and Persistence of the Institute for Biochemistry I, University of Cologne, Cilium: A New Perspective. P. Satir, A. Bell, C. F. Cologne, Germany 437 B372 Investigating the Role of the Guerra; Anatomy and Structural Biology, Albert APC2, Armadillo, and ␣-catenin Ternary Einstein College of Medicine, Bronx, NY 428 B363 Functional Roles of VASP Complex in Actin Organization. M. Zhou, A. L. Phosphorylation in Response to Osmotic Blitzer, B. M. McCartney; Biological Sciences, 447 B382 An Exhaustive Search for Cililary 1 2 Stress or cAMP Stimulus. W. Lin, J. S. Gruver, Carnegie Mellon University, Pittsburgh, PA Genes in the Worm C. elegans. P. Phirke,1,2 P. C. Y. Chung2; 1Biological Sciences, Vanderbilt Swoboda1,2; 1Department of Biosciences & University, Nashville, TN, 2Pharmacology, 438 B373 N-terminal APC Fragments Nutrition, Karolinska Institute, Stockholm-Huddinge, Vanderbilt University Medical Center, Nashville, TN Disrupt Cell Spreading and Actin Sweden, 2School of Life Sciences, Södertörn Polymerisation. L. Leung,1 K. Kita,2 C. M. University College, Stockholm-Huddinge, Sweden 429 B364 Swf1p/Psl10p Is a DHHC-CRD Waterman,3 K. Siemers,4 I. S. Näthke1; 1School of Palmitoyltransferase That Regulates Actin. S. Life Sciences, University of Dundee, Dundee, 448 B383 WITHDRAWN 1 2 1 Dighe, K. G. Kozminski ; Department of Biology, United Kingdom, 2Scripps, La Jolla, CA, 3National 449 B384 Dynamic Properties of University of Virginia, Charlottesville, VA, Heart Lung and Blood Institute, Bethesda, MD, 2 Microtubules in Primary Cilia. O. Belzile, W. J. Departments of Biology and Cell Biology, 4Biological Sciences, Stanford University, Stanford, Snell; Cell Biology, University of Texas University of Virginia, Charlottesville, VA CA Southwestern Medical Center at Dallas, Dallas, TX 430 B365 Abundant Expression of Adaptor 439 B374 Retraction Kinetics of Severed 450 B385 Human Embryonic Stem Cells in Protein CAP/Ponsin in Lens and Its Down- Stress Fibers. M. Stachowiak, B. O'Shaughnessy; ␣ Culture Possess Primary Cilia with Signaling Regulation in Rho GDI Transgenic and Abi-1/ Department of Chemical Engineering, Columbia 1 Properties. E. N. Kiprilov,1 A. Awan,2 M. Velho,1 C. Abi-2 Knock-Out Mouse Lenses. R. Maddala, A. University, New York, NY Pendergast,2 V. P. Rao3; 1Ophthalmology, Duke A. Clement,2 A. G. Byskov,2 C. Y. Andersen,2 S. T. University School of Medicine, Durham, NC, 440 B375 Actin Stress Fiber Alteration by Christensen,2 P. Satir,1 E. E. Bouhassira,1 R. E. 2Pharmacology and Cancer Biology, Duke the Hyperglycemia, TGF␤1 and IL-6. K. A. Hirsch1; 1Anatomy and Structural Biology, Albert University School of Medicine, Durham, NC, Barbosa Sabanero,1 M. Cruz López,2 L. Salgado,3 Einstein College of Medicine, Bronx, NY, 3Ophthalmology, Pharmacology and Cancer G. Barbosa-Sabanero,1 M. Sabanero4; 1Instituto de 2Laboratory of Reproductive Biology, Biology, Duke University School of Medicine, Investigaciones Médicas, Universidad de Rigshospitalet, University of Copenhagen, Durham, NC Guanajuato, Guanajuato, Mexico, 2Unidad de Copenhagen, Denmark Investigación en Bioquímica, Centro Médico 451 B386 Deletion of IFT20 in Vertebrate 431 B366 Coronin 2A Regulates Cofilin Nacional Siglo XXI, México D.F., Mexico, Activity through Slingshot-1L and Is Important 3Bioquímica, Centro de Investigación y de Estudios Photoreceptors Leads to Opsin Transport for EGF-induced Focal Adhesion Turnover. T. W. Avanzados del IPN, México D.F., Mexico, 4Instituto Defects and Retinal Degeneration. B. T. Keady, Marshall, J. E. Bear; Lineberger Comprehensive de Investigación en Biología Experimental, J. Follit, J. SanAgustin, G. Pazour; Molecular Cancer Center and Department of Cell and Universidad de Guanajuato, Guanajuato, Mexico Medicine, University of Massachusetts Medical Developmental Biology, University of North School, Worcester, MA Carolina, Chapel Hill, NC 441 B376 Intracellular Sorting of Isoforms Using Fluorescent- 452 B387 Mutations in Hydin Impair Ciliary ␤ 1 P. Delmotte,2 M. 432 B367 Effects of Thymosin 4on tagged Tropomyosin Constructs. C. A. Martin,1,2 Motility in Mice. K. F. Lechtreck, 3 M. J. Sanderson,2 G. B. Witman1; Cytoskeletal Organization and Cell Motility. L. G. Schevzov,1,2 P. W. Gunning1,2; 1Oncology L. Robinson, 1,2 1 1Department of Cell Biology, University of Jaafar, P. Kollmannsberger, D. Paranhos- Research Unit, The Children's Hospital at 1 1 1 1 Massachusetts Medical School, Worcester, MA, Zitterbart, C. Raupach, B. Fabry ; Biophysics Westmead, Sydney, Australia, 2Discipline of 2Department of Physiology, University of Group, Center for Medical Physics and Technology, Paediatrics and Child Health, University of Sydney, 2 Massachusetts Medical School, Worcester, MA, Erlangen, Germany, Biophysics Group, Center of Sydney, Australia Medical Physics and Technology, University of 3Zoology Department, Miami University, Oxford, OH Erlangen-Nuremberg, Germany, Erlangen, 442 B377 Tropomyosins Regulate Actin 453 B388 Characterization of a Golgi- Germany Organization by Defining the Recruitment associated IFT Complex. J. A. Follit,1 J. Patterns of Actin Binding Proteins. P. Gunning,1 ␥ 2 J. SanAgustin,1 G. Pazour1; 1Molecular 433 B368 The Interferon- -induced Murine S. Creed,1 N. Bryce,1 R. Weinberger,1 J. Jonassen, Medicine, University of Massachusetts Medical Guanylate Binding Protein-2 (mGBP-2) Inhibits Bamburg,2 J. Stehn1; 1Oncology Research Unit, 2Physiology, University of Rac Activation Both in Spreading and PDGF The Children's Hospital at Westmead, Sydney, School, Worcester, MA, Massachusetts Medical School, Worcester, MA Treatment by Signaling. A. F. Messmer; Biological Australia, 2Biochemistry and Molecular Biology, Sciences, University of Toledo, Toledo, OH Colorado State University, Colorado, CO 454 B389 G Protein Signaling and the 434 B369 The Role of WASP and N-WASP 443 B378 A Novel Role for a Type V Myosin GMAP210 Homologue SQL-1 Modulate in Monocyte/Macrophage Morphology. L. M. in the Regulation of Actin Dynamics. J. H. Yu, Intraflagellar Transport in C. elegans. J. 1 1 2 1 1 M. Dekkers,1 S. Rademakers,1 T. de Nusblat, B. Isaac, J. Gevrey, J. Condeelis, D. M. Bettenbuehl, A. H. Crevenna, R. Wedlich- Burghoorn, 1 1 Jong,2 R. Willemsen,3 E. Efimenko,4 P. Swoboda,4 Cox ; Anatomy and Structural Biology, Albert Soldner; Cellular Dynamics and Cell Patterning, 2 G. Jansen1; 1Cell Biology, Erasmus MC, Einstein College of Medicine, Bronx, NY, U45, Max-Planck-Institute of Biochemistry, Martinsried, Rotterdam, The Netherlands, 2Pathology, Erasmus INSERM, Lyon, France Germany MC, Rotterdam, The Netherlands, 3Clinical Genetics, Erasmus MC, Rotterdam, The Netherlands, 4Biosciences and Nutrition, Karolinska Institute, Stockholm, Sweden

67 SUNDAY The American Society for Cell Biology 47th Annual Meeting Poster Session 1 B390–B419 December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org

455 B390 Cholangiocyte Cilia Express 465 B400 Central Role for DYF-11/MIP-T3 in 474 B410 The Sharp Boundary between TRPV4 and Detect Changes in Luminal Tonicity Assembling the Intraflagellar Transport (IFT) Filament Assembly and Disassembly at the Cell Inducing Bicarbonate Secretion. S. A. Gradilone, Machinery Required for Cilia Formation. P. N. Leading Edge Is an Emergent Property of Actin A. I. Masyuk, P. L. Splinter, B. Q. Huang, P. S. Inglis,1 C. Li,1 C. C. Leitch,2 E. Efimenko,3 N. Biochemistry, Diffusion, and Advection. J. Ditlev, Tietz, J. M. Banales, T. V. Masyuk, N. F. LaRusso; Bialas,1 P. Swoboda,3 N. Katsanis,2 M. R. Leroux1; I. Novak, N. Vacanti, L. Loew; R. D. Berlin Center Department of Internal Medicine, Mayo Clinic 1Molecular Biology and Biochemistry, Simon Fraser for Cell Analysis and Modeling, University of College of Medicine, Rochester, MN University, Burnaby, BC, Canada, 2McKusick- Connecticut Health Center, Farmington, CT Nathans Institute of Genetic Medicine, Johns 456 B391 Cholangiocyte Primary Cilia Hopkins University, Baltimore, MD, 3Department of 475 B411 Adhesion Maturation Is Mediated Express the Elements of the cAMP Signalling Biosciences and Nutrition, Karolinska Institute, by Contractility and Actin Bundling along an 1 Cascade Necessary for Ciliary Sensory Huddinge, Sweden Actin Template. C. K. Choi, M. Vicente- Functions. A. I. Masyuk, J. M. Banales, S. A. Manzanares,2 J. Zareno,2 A. F. Horwitz2; Gradilone, T. V. Masyuk, B. Q. Huang, A. J. 466 B401 Possible Role of Primary Cilium 1Biomedical Engineering, University of Virginia, Stroope, N. F. LaRusso; Internal Medicine, Mayo in the Peritoneal Fibrosis. Y. Kitami, T. Kawate, Charlottesville, VA, 2Cell Biology, University of Clinic College of Medicine, Rochester, MN K. Narita, S. Takeda; Department of Anatomy and Virginia, Charlottesville, VA Cell Biology, University of Yamanashi Faculty of 457 B392 Ciliary and Centrosomal Medicine, Yamanashi, Japan 476 B412 How Depolymerization Can Dysfunctions in Cholangiocytes of the PCK Rat, Promote Polymerization? E. G. Yarmola,1,2 D. A. an Animal Model of Autosomal Recessive Dranishnikov,1,2 M. R. Bubb1,2; 1Medicine, Polycystic Kidney Disease (ARPKD), Are Actin Dynamics and Assembly I University of Florida, Gainesville, FL, 2Research Associated with Fibrocystin Mis-Localization: Service, N. Florida/S. Georgia Veterans Health Implications to Hepatic Cystogenesis. T. V. 467 B403 The F-Bar Protein CIP4 Promotes System, Gainesville, FL Masyuk, S. Lee, B. Q. Huang, A. I. Masyuk, A. J. Breast Cancer Cell Migration and Invasion. C. 477 B413 Non-static Properties of Cross- Stroope, N. F. LaRusso; Internal Medicine, Mayo S. Pichot, S. M. Hartig, S. J. Corey; University of linked Actin Networks. O. Lieleg, Y. Luan, M. Clinic College of Medicine, Rochester, MN Texas MD Anderson Cancer Center, Houston, TX Claessens, A. R. Bausch; Physics Department, TU 458 B393 Molecular Player of Cilia 468 B404 Candida albicans Stimulated München, Lehrstuhl E22 für Biophysik, Garching, Function. B. Chih, A. Peterson; Molecular Biology, Actin Filament Dynamics and Altered Germany Genentech, South San Francisco, CA Localization of ABP`s in Human Oral 478 B414 Self-Organization of F-actin Near Keratinocytes. T. Woellert,1 M. Young,1 C. 459 B394 Identification of a G-Protein Surfaces without Binding Proteins. C. I. Fisher, Rollenhagen,2 G. M. Langford1; 1Biology Coupled Receptor (GPCR) Ciliary Targeting S. C. Kuo; Biomedical Engineering, Johns Hopkins Department, University of Massachusetts, Amherst, Sequence and Novel Ciliary GPCRs. K. Mykytyn, University, Baltimore, MD MA, 2Department of Microbiology, Dartmouth N. Berbari, J. Lewis, C. Askwith; The Ohio State Medical School, Hanover, NH University, Columbus, OH 479 B415 A Hybrid Model for Actin Cable Dynamics in Fission Yeast. H. Wang, D. 469 B405 Regulation of Intracellular 460 B395 Functional Roles for Meckelin Vavylonis; Physics, Lehigh University, Bethlehem, Structure, Polarity, and Dynamics of Actin (MKS3/TMEM67) in Ciliogenesis. M. Adams,1 H. PA Networks by Protein Arginylation. S. Saha,1 F. R. Dawe,2 C. V. Logan,1 U. M. Smith,3 D. A. Kelly,4 Zhang,1 A. Mogilner,2 F. Korobova,3 T. Svitkina,3 A. C. A. Johnson1; 1Opthalmology & Neurosciences 480 B416 The Fringe: An F-actin Cortical Kashina1; 1Department of Animal Biology, (Level 8), Leeds Institute of Molecular Medicine, Structure Is Conserved in Tip Growing Cells. L. University of Pennsylvania, Philadelphia, PA, Leeds, United Kingdom, 2Sir William Dunn School Vidali, R. Augustine, M. Bezanilla; Biology, 2University of California, Davis, CA, 3Department of of Pathology, University of Oxford, Oxford, United University of Massachusetts at Amherst, Amherst, Biology, University of Pennsylvania, Philadelphia, Kingdom, 3The Liver Research Laboratories, MA PA Institute of Biomedical Research, University of 481 B417 Palladin Is an Actin Crosslinking Birmingham Medical School, Birmingham, United 470 B406 Ochestration of Intracellular Protein That Uses Immunoglobulin Domains to Kingdom, 4The Liver Unit, Birmingham Childrens Forces during (Epithelial) Cell Protrusion. L. Ji, Bind F-Actin. R. D. S. Dixon,1 D. K. Arneman,2 A. Hospital, Birmingham, United Kingdom J. Lim, G. Danuser; Cell Biology, The Scripps S. Rachlin,2 J. Costello,3 S. L. Campbell,1 C. A. Research Institute, La Jolla, CA 2 1 461 B396 Dynamic Remodeling of Primary Otey ; Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC, 2Cellular & Cilia Membranes. C. M. Ott, J. Lippincott- 471 B407 In Vitro Studies of Actin Network Molecular Physiology, University of North Carolina, Schwartz; Cell Biology and Metabolism, NICHD, Assembly and Mechanical Failure. V. I. Risca,1,2 Chapel Hill, NC, 3Cell & Developmental Biology, NIH, Bethesda, MD K. E. Kasza,3,2 A. Hilfinger,4,2 R. D. Mullins5,2; University of North Carolina, Chapel Hill, NC 1Biophysics Graduate Group, University of 462 B397 Bardet-Biedl Syndrome Proteins California, Berkeley, CA, 2Physiology Course, MBL, Are Required for the Localization of G-Protein 482 B418 Conventional and Novel PKCs Woods Hole, MA, 3School of Engineering and Coupled Receptors to Neuronal Cilia. N. F. Differentially Regulate Rho GTPases during Applied Sciences, Harvard University, Cambridge, 1 Berbari,1 G. A. Bishop,2 J. S. Lewis,1 K. Mykytyn1; Single Cell Wound Healing. E. M. Vaughan, H. MA, 4Department of Systems Biology, Harvard 1 2 1 1Pharmacology, The Ohio State University, E. Yu, W. M. Bement ; Program in Cell and Medical School, Boston, MA, 5Cellular and Columbus, OH, 2Neuroscience, The Ohio State Molecular Biology, University of Wisconsin, Molecular Pharmacology, University of California, 2 University, Columbus, OH Madison, WI, Department of Zoology, University of San Francisco, CA Wisconsin, Madison, WI 463 B398 Loss of Bardet-Biedl Protein 472 B408 Actin Dynamics and Contractility Alters the Morphology and Function of Motile 483 B419 The Kinesins KIF1C and KIF9 in Single Cell Wound Healing. B. Burkel, W. Cilia in Airway Epithelia. A. S. Shah,1 S. L. Regulate Different Podosome Subpopulations Bement; Zoology, University of Wisconsin, 1 Farmen,1 T. O. Moninger,1 M. P. Andrews,2 T. R. in Primary Human Macrophages. S. Cornfine, P. Madison, WI 1 2 3 4 Businga,1 C. C. Searby,2 D. Nishimura,2 K. A. Kopp, M. Sixt, R. Lammers, T. Rudel, N. 4 1 1 3 1 2,4 Machuy, S. Linder ; Institut für Prophylaxe und Brogden, J. N. Kline, V. C. Sheffield, M. J. 473 B409 Kinetics of Stress Fibers: The Welsh1,4; 1Internal Medicine, University of Iowa, Epidemiologie der Kreislaufkrankheiten, LMU, Interaction of Actin Turnover and Contractility. 2 2 Muenchen, Germany, Department for Molecular Iowa City, IA, Pediatrics, University of Iowa, Iowa M. Stachowiak, B. O'Shaughnessy; Department of City, IA, 3Periodontics, University of Iowa, Iowa Medicine, Max-Planck-Institut für Biochemie, Chemical Engineering, Columbia University, New 3 4 Muenchen, Germany, Medizinische Klinik IV, City, IA, Howard Hughes Medical Institute, Iowa York, NY City, IA Universitaet Tuebingen, Tuebingen, Germany, 4Max-Planck-Institut für Infektionsbiologie, Berlin, 464 B399 Vesicular Transport to the Germany Primary Cilium: The Role of the BBSome and Rab8. M. Nachury; Tumor Biology and Angiogenesis, Genentech, South San Francisco, CA

68 The American Society for Cell Biology 47th Annual Meeting SUNDAY December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org Poster Session 1 B420–B448

484 B420 A Computational Model Reveals 494 B430 Force-induced Bidirectional 503 B440 Secretory Protein Distribution in the Mechanisms of Actin-based Bead Motility. Stepping of Cytoplasmic Dynein. A. Gennerich, Diabetic Human Salivary Glands. M. I. Piras,1 M. M. J. Dayel,1 M. Landeryou,2 O. Akin,3 A. A. Carter, S. Reck-Peterson, R. Vale; Cellular and Piludu,1 E. Proto,2 M. Mednieks,3 A. Hand4; Mogilner,4 R. Mullins3; 1Miller Institute for Basic Molecular Pharmacology, University of California, 1University of Cagliari, Cagliari, Italy, 2Clinic of Research in Science/MCB, University of California, San Francisco, San Francisco, CA Otolaryngology, University of Cagliari, Cagliari, Berkeley, Berkeley, CA, 2Centre for Clinical Italy, 3Oral Health and Diagnostic Services, Science & Technology, University College London, 495 B431 Functional Analysis of Putative University of Connecticut, Farmington, CT, London, United Kingdom, 3Cellular and Molecular Cytoplasmic Dynein Subpopulations in 4Craniofacial Sciences, University of Connecticut Pharmacology, University of California, San Drosophila melanogaster. R. B. Parikh, D. J. Health Center, Farmington, CT Francisco, San Francisco, CA, 4Department of Sharp; Physiology & Biophysics, Albert Einstein Mathematics, University of California, Davis, Davis, College of Medicine, Bronx, NY 504 B441 Annexin 2 and Diabetic Vascular 1 1 CA Disease. M. A. Evans, J. Greenwood, K. A. 496 B432 Potential Cytoplasmic Dynein Hajjar,2 Q. Ling,2 M. F. Cordeiro,3 S. E. Moss1; 485 B421 Simulation of Actin-driven Bead Inhibitors in C. elegans: Light Chains Suppress 1Cell Biology, Institute of Ophthalmology, London, Motility. K. Lee, A. J. Liu; Physics and Astronomy, Heavy Chain Mutants. S. M. O'Rourke, B. United Kingdom, 2Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA Bowerman; Institute of Molecular Biology, Weill Medical College of Cornell University, New University of Oregon, Eugene, OR York, NY, 3Pathology and Glaucoma and Optic 486 B422 Structure of Actin Nucleation Nerve Head Research Group, Institute of 497 B433 Small Molecule-mediated Seeds Assembled via Tandem WH2 Domains. G. Ophthalmology, London, United Kingdom Rebowski,1 M. Boczkowska,1 M. Petoukhov,2 D. Sequestration of Cytoplasmic Dynein LC8 Hayes,3 L. Guo,4 T. C. Irving,4 D. Svergun,2 R. Causes Rapid Inhibition of Intracellular Motility. 505 B442 Flux Analysis and Metabolomics 1 1 2 Dominguez1; 1Physiology Department, University of D. Varma, A. Ghosh-Roy, A. Dawn, R. B. of Rat Hepatocyte Gluconeogenesis. L. Guillen,1 1 2 1 Pennsylvania Medical School, Philadelphia, PA, Vallee, J. C. Williams ; Pathology and Cell J. O. Aleman,2,3 M. Antoniewicz,2 G. 2DESY, EMBL, Hamburg, Germany, 3Boston Biology, Columbia University, New York, NY, Stephanopoulos2; 1Industrial Biotechnology, 2 Biomedical Research Institute, Watertown, MA, Microbiology and Immunology, Kimmel Cancer University of Puerto Rico–Mayaguez Campus, 4Advanced Photon Source, Argonne National Center, Thomas Jefferson University, Philadelphia, Mayaguez, Puerto Rico, 2Chemical Engineering, Laboratory, Argonne, IL PA Massachusetts Institute of Technology, Cambridge, MA, 3Harvard University, Cambridge, MA 487 B423 Ultrahigh Resolution Force 498 B434 New Tasks for Dynein. H. Measurements of Cytoskeleton Dynamics. B. W. Drechsler, J. Ortiz, D. Liakopoulos; Heidelberg 506 B443 Alcohol Induces Global Hepatic Axelrod,1 M. L. Roukes2; 1Applied Physics, University Biochemistry Center, Heidelberg, Protein Hyperacetylation. B. D. Shepard,1 D. J. California Institute of Technology, Pasadena, CA, Germany Tuma,2 P. L. Tuma1; 1Department of Biology, The 2Physics, California Institute of Technology, 499 B435 Par3 Associates with Dynein Catholic University of America, Washington, DC, Pasadena, CA 2Department of Internal Medicine, University of Light Intermediate Chain 2 to Locally Regulate Nebraska Medical Center, Omaha, NE 488 B424 Solution Structure of Arp2/3 Microtubule Dynamics and Polarize the 1 Complex Bound to Actin and the WH2-C-A of Centrosome in Migrating Cells. J. Schmoranzer, 507 B444 Interactions of Aggregated LDL 2 1 1 1 WASP. M. Boczkowska,1 G. Rebowski,1 M. J. P. Fawcett, M. Segura, S. Tan, R. B. Vallee, with Macrophages. I. Grosheva,1 C. Qin,1 T. 3 1 1 Petoukhov,2 D. B. Hayes,3 D. Svergun,2 R. T. Pawson, G. G. Gundersen ; Pathology, Nagao,1 F. R. Maxfield,1 L. M. Pierini2; 2 Dominguez1; 1Physiology Department, University of Columbia University, New York, NY, Departments 1Biochemistry, Weill Medical College, New York, Pennsylvania Medical School, Philadelphia, PA, of Pharmacology and Surgery, Dalhousie NY, 2Surgery, Weill Medical College, New York, NY 3 2DESY, EMBL, Hamburg, Germany, 3Boston University, Halifax, NS, Canada, Samuel Biomedical Research Institute, Watertown, MA Lunenfeld Research Institute, Mount Sinai Hospital, 508 B445 A Marker for Foam Cell Death Toronto, ON, Canada (PC-Cholesterol Complex) Can Be Expressed in Foam Cells. M. Mori,1 I. Kimura,1 N. Maeda,1 N. Dynein I 500 B436 Dynein Regulates Nuclear Takahashi,1 A. Umino,1 A. Ogura,1 H. Itabe,2 T. Movement during Forward Progression of Takano,3 M. Fujimoto1; 1Applied Pharmacology, Motile Fibroblasts. J. R. Levy, E. L. F. Holzbaur; 489 B425 Motor Domain-mediated Faculty of Pharmaceutical Science, Chiba Institute Department of Physiology, University of 2 Regulation of Outer Arm Dynein. R. S. Patel- of Science, Chiba, Japan, Biochemistry Faculty of Pennsylvania, Philadelphia, PA King, S. M. King; Department of Molecular, Pharmaceutical Science, Showa University, Tokyo, Microbial and Structural Biology, University of Japan, 3Molecular Pathology, Faculty of Connecticut Health Center, Farmington, CT Metabolic Disease Pharmaceutical Science, Teikyo University, Kanagawa, Japan 490 B426 Dynein Light Chain 4 (LC4) Regulates the Recovery from Ciliary Reversal in 501 B438 Secretory Protein Expression in 509 B446 Analysis of Glucose Transporter Tetrahymena thermophila. D. E. Wilkes, E. Heyer, Salivary Glands of Diabetic Psammomys Redistribution in Adipocytes by Live-Cell 1 2 3 M. Hubenschmidt, H. Kuhn, A. Wiedeman, V. obesus. M. I. Mednieks, E. Ziv, R. Kalman, A. Imaging. Y. Hosoya,1 N. Satoshi,1 N. Ryozo,1 S. 4 1 Rajagopalan, D. J. Asai; Biology, Harvey Mudd R. Hand ; Oral Health and Diagnostic Sciences, Seiryo2; 1Department of Cardiovascular Medicine, College, Claremont, CA University of Connecticut Health Center, The University of Tokyo, Tokyo, Japan, Farmington, CT, 2Division of Internal Medicine, 2Department of Human Environmental Studies, The 491 B427 Dissection of Inter-modular Hadassah University Hospital, Jerusalem, Israel, University of Tokyo, Tokyo, Japan Communication among Multiple Nucleotide- 3Director, Authority for Animal Facilities, Hebrew binding/Hydrolysis Sites of Cytoplasmic University, Jerusalem, Israel, 4Craniofacial 510 B447 Effect of Oxidation on Mitotic Dynein. T. Mogami, K. Imamula, R. Ohkura, K. Sciences, University of Connecticut Health Center, Clonal Expansion in Adipocyte Differentiation. Sutoh, T. Kon; Life Sciences, University of Tokyo, Farmington, CT J. Kim; Biochemistry and Molecular Biology, Yonsei Tokyo, Japan University College of Medicine, Seoul, Republic of 502 B439 Stress, Cell Density, and Korea 492 B428 Dissection of Distinct ATP Sites Signaling through the MEK->ERK1/2 Pathway in Cytoplasmic Dynein. C. Cho, S. Reck- Control the Subcellular Distribution of AMP- 511 B448 Adipocyte Differentiation-related Peterson, R. D. Vale; University of California, San activated Protein Kinase. M. Kodiha,1 P. Banski,1 Protein Reduces Lipid Droplet Association of Francisco, San Francisco, CA J. G. Rassi,1 C. M. Brown,2 U. Stochaj1; Adipose Triglyceride Lipase and Slows 1Physiology, McGill University, Montreal, PQ, Triacylglycerol Turnover. L. Listenberger,1 A. 493 B429 Two Wrongs Make a Right: An Canada, 2Biochemistry, McGill University, Montreal, Ostermeyer-Fay,1 E. Goldberg,2 W. Brown,2 D. Analysis of the Microtubule Binding Domain of PQ, Canada Brown1; 1Department of Biochemistry and Cell Dynein. D. S. Razafsky, J. Ma, R. Schnittker, D. Biology, Stony Brook University, Stony Brook, NY, Madole, M. D. Plamann, S. J. King; School of 2Department of Molecular Biology and Genetics, Biological Sciences, University of Missouri, Kansas Cornell University, Ithaca, NY City, MO

69 SUNDAY The American Society for Cell Biology 47th Annual Meeting Poster Session 1 B449–B475 December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org

512 B449 Seipin, Mutated in Human 522 B459 Uptake of AGEs in Kidney 530 B467 Fungal Cell Wall Glycoproteins Lipodystrophy, Is Important for Lipid Body Proximal Tubule Epithelial Cells by Involved in Adhesion to Epithelium. S. A. Assembly or Maintenance. K. M. Szymanski, D. Macropinocytosis. M. A. Gallicchio,1 L. A. Myrna,1 G. Sandoval Bernal,1 G. Barbosa- Binns, J. M. Goodman; Pharmacology, University of Bach2,1; 1Medicine, Monash University, Melbourne, Sabanero,1 M. Shibayama,2 V. Tsutsumi2; 1Instituto Texas Southwestern Medical Center, Dallas, TX Australia, 2Endocrinology and Diabetes, Alfred de Investigación en Biología Experimental, Hospital, Melbourne, Australia Universidad de Guanajuato, Guanajuato, Mexico, ␤ 513 B450 Diabetes Increases TGF 2 2Patología Experimental, Centro de Investigación y Signaling and Extracellular Matrix Proteins in 523 B460 Identification and Quantification de Estudios Avanzados del IPN, México D.F., 1 the Rat Salivary Gland. M. L. Lamers, T. T. S. of Serum Markers for Predicting Severity and Mexico D'Epiro,1 J. Nicolau,2 P. Gama,1 M. F. Santos1; Monitoring Progression of Acute Pancreatitis: 1Cell and Developmental Biology, University of São 1H Nuclear Magnetic Resonance Spectroscopic 531 B468 NF-kB Regulation of a Cellular Paulo, São Paulo, Brazil, 2School of Dentistry, Study. M. Srivastava,1 A. Sharma,2 V. K. Kapoor,2 MicroRNA, Let-7i, Contributes to BIliary University of São Paulo, São Paulo, Brazil G. A. N. Gowda,3 D. K. Gupta1; 1Department of Epithelial Immunity against Cryptosporidium Biochemistry, University of Allahabad, Allahabad, parvum Infection. P. L. Splinter,1 S. P. O'Hara,1 C. 514 B451 JNK Activation Causes India, 2Department of Surgical Gastroenterology, E. Trussoni,1 G. B. Gajdos,1 X. Chen,2 N. F. Endoplasmic Reticulum Stress Response in Sanjay Gandhi Postgraduate Institute of Medical LaRusso1; 1GI Basic Research, Mayo Clinic Adipocytes to Suppress the Adiponectin Sciences, Lucknow, India, 3Centre of Biomedical College of Medicine, Rochester, MN, 2Medical Secretion In Vivo. H. Aoki, S. Itoh, S. Matsumoto, Magnetic Resonance, Sanjay Gandhi Postgraduate Microbiology and Immunology, Creighton K. Yoshimura, Y. Ikeda, M. Matsuzaki; Department Institute of Medical Sciences, Lucknow, India University, Omaha, NE of Molecular Cardiovascular Biology, Yamaguchi University School of Medicine, Ube, Japan 524 B461 Cloning and Characterization of 532 B469 HIV-1 Tat Protein Decreases Scleraxis: Fibrosis- and Sclerosis-specific Cholangiocyte TLR4 Expression and Abrogates 515 B452 Mitochondrial Stress, Energy Basic HLH Transcription Factor. H. Abe,1,2 T. Epithelial Immune Responses against Metabolism, and Cytoskeletal Organization: Tominaga,2 T. Araoka,1 T. Murakami,1 T. Cryptosporidium parvum Infection. S. P. Effects of Selenium. J. Szczepanowska, A. Czyz, Takahashi,1 T. Doi1; 1University of Tokushima, O'Hara,1 A. J. Small,1 P. L. Splinter,1 G. B. M. Wieckowski, J. Duszynski; Biochemistry, Nencki Tokushima, Japan, 2Research Institute for Gajdos,1 C. E. Trussoni,1 X. Chen,2 N. F. Institute of Experimental Biology, Warsaw, Poland Production Laboratory, Kyoto, Japan LaRusso1; 1Center for Basic Research in Digestive Diseases, Mayo Clinic, Rochester, MN, 2Medical 516 B453 Evidence That Inhibition of Microbiology and Immunology, Creighton Hemojuvelin Shedding in Response to Iron Is Host-Non-Bacterial Pathogen Interactions University, Omaha, NE Mediated Through Neogenin. A. Zhang,1 S. A. Anderson,2 K. R. Meyers,1 C. Hernandez,1 R. S. 525 B462 Interception of Vesicular Traffic 533 B470 HIV-1 Nef Protein Can Remove Eisenstein,2 C. A. Enns1; 1Cell & Developmental from Host Golgi Exit Sites by Intracellular Cell-Surface MHC Class II by Enhanced Biology, Oregon Health and Science University, 1 2 Endocytosis. D. A. Verghese,1 A. Chaudhry,1 S. 2 Toxoplasma. J. D. Romano, R. Goldszmid, A. Portland, OR, Department of Nutritional Sciences, 2 2 3 1 Sher,2 I. Coppens1; 1Molecular Microbiology and R. Das, S. Jameel, S. Mayor, A. George, V. University of Wisconsin–Madison, Madison, WI 1 1 1 Immunology, Johns Hopkins Bloomberg School of Bal, S. Rath ; National Institute of Immunology, 2 2 517 B454 Abnormal Processing of Public Health, Baltimore, MD, Immunobiology New Delhi, India, Virology, International Centre for Uromodulin (UMOD) in Fabry Disease Patients Section and Immunopathogenesis Section, Genetic Engineering and Biotechnology, New Delhi, 3National Centre for Biological Sciences, Reflects Kidney Tubular Cell Storage Alteration Laboratory of Parasitic Diseases, National Institute India, Bangalore, India and Is Reversible by Enzyme Replacement of Allergy and Infectious Diseases, Bethesda, MD Therapy. P. Vyletal,1,2 H. Hulkova,1 P. Novak,3 M. 526 B463 Characterization of Plasmodium 534 B471 Inhibitory Plant Lectins Select for Kublova,1,2 L. Berna,1 M. Elleder,1,2 S. Kmoch1,2; falciparum Erythrocyte-binding Ligand EBL-1. Replication-Competent Simian 1Institute of Inherited Metabolic Disorders, 1st G. Mayer; Virginia Commonwealth University, Immunodeficiency Virus Variants Deficient in Faculty of Medicine, Prague, Czech Republic, Sites for Carbohydrate Attachment. E. Stansell, 2 Richmond, VA Center for Applied Genomics, Prague, Czech R. Desrosiers; Microbiology, Harvard Medical 3 Republic, Institute of Microbiology, Laboratory of 527 B464 Large Phagocytic Loads Promote School, Southborough, MA Molecular Structure Characterization, Academy of Macrophage Desactivation and This May Result Sciences of the Czech Republic, Prague, Czech from Altered Nitric Oxide Synthase Intracellular 535 B472 Dengue Virus Replication and Republic Location. A. Niño,1 L. Lagos,2,3 N. Vega,1 A. Endoplasmic Reticulum Stress. J. Duran, P. Rojas,4 M. Camargo,5 M. Camacho5,2; Acosta, J. Ramos-Castaneda; Arbovirus, Instituto 518 B455 Creation of a Mouse Model for 1Departamento de Química, Universidad Nacional Nacional de Salud Publica, Cuernavaca, Mexico Human Hereditary Inclusion Body Myopathy. D. de Colombia, Bogotá, Colombia, 2Laboratorio de Hickey,1 R. Klootwijk,1 W. Bond,1 I. Manoli,1 C. 536 B473 The Association of Positive Biofísica, Centro Internacional de Física, Bogotá, Ciccone,1 D. Darvish,2 W. A. Gahl,1 M. Huizing1; Transcription Elongation Factor b (P-TEFb) with Colombia, 3Programa de Doctorado en Ciencias 1NIH, NHGRI, Bethesda, MD, 2HIBM Research Dengue Virus Core Protein Stimulates the Biomédicas, Facultad de Salud, Universidad del Group, Encino, CA Production of Interleukin-8. Y. Ping; Institute of Valle, Cali, Colombia, 4Departamento de Farmacia, Pharmacology, National Yang-Ming University, 519 B456 GLA Gene Silencing and Fabry Universidad Nacional de Colombia, Bogotá, 5 Taipei, Taiwan Disease. M. J. Kim, N. Luu, C. R. Kaneski; DMNB/ Colombia, Departamento de Biología, Universidad NINDS, NIH, Bethesda, MD Nacional de Colombia, Bogotá, Colombia, 537 B474 Determination of Hepatitis B Virus (HBV) Gene Mutation by Lamivudine and 528 B465 Leishmania Induces Deactivation 520 B457 Mutation in the Key Enzyme of Adefovir. C. Lee, Y. Lee, J. Keum, D. Kim, Y. and May Reduce Apoptosis in Infected Sialic Acid Biosynthesis Causes Severe Hwang; Division of Biological Science, Gachon Macrophages. C. Fajardo,1 M. Forero,2 Y. Villota,3 Glomerular Proteinuria and Is Rescued by N- University of Medicine & Science, Incheon, 1 1 A. Rojas,4 M. Camacho5,2; 1Departamento de acetylmannosamine. M. Huizing, R. Klootwijk, I. Republic of Korea Manoli,1 B. Galeano,1 D. Hickey,1 W. Bond,1 C. Química, Universidad Nacional de Colombia, 2 Ciccone,1 D. Darvish,2 D. Krasnewich,1 W. A. Bogotá, Colombia, Laboratorio de Biofísica, 538 B475 Transcytosis of Hepatitis A Virus Gahl1; 1NHGRI, NIH, Bethesda, MD, 2HIBM Centro Internacional de Física, Bogotá, Colombia, (HAV) Is Required for Efficient Export of 3 Research Group, Encino, CA Departamento de Física, Universidad Nacional de Infectious Virus. N. A. Counihan,1,2 M. J. 4 Colombia, Bogotá, Colombia, Departamento de Snooks,3 D. A. Anderson3; 1Burnet Institute, 521 B458 Adenosine Receptor A2B Farmacia, Universidad Nacional de Colombia, Melbourne, Victoria, Australia, 2Microbiology, 5 Increases the VEGF Release and Expression in Bogotá, Colombia, Departamento de Biología, Monash University, Melbourne, Victoria, Australia, Isolated Rat Kidney Glomeruli. D. Valladares, P. Universidad Nacional de Colombia, Bogotá, 3Hepatitis, Burnet Institute, Melbourne, Victoria, Montecinos, T. Sotelo, I. Concha, R. San Martin; Colombia Australia Instituto de Bioquimica, Universidad Austral de Chile, Valdivia, Chile 529 B466 Zinc Regulation of the Candida albicans Developmental Regulator HBR1. M. L. Pendrak, D. D. Roberts; Pathology, NCI, Bethesda, MD

70 The American Society for Cell Biology 47th Annual Meeting SUNDAY December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org Poster Session 1 B476–B503

539 B476 Entry of DAF Binding and Non- 549 B486 In Situ Characterization of the 558 B495 Type I Interferon Signaling in 1 DAF Binding Coxsackieviruses into Non- Phospholipase A2-activating Protein (PLAA). F. Human Dendritic Cells. G. A. Viswanathan, B. M. Polarized Cells. K. Patel,1,2 C. Coyne,3 J. Zhang,1 C. L. Galindo,2 J. Sha,1 G. Suarez,1 J. C. Hartmann,1 S. Y. Shvartsman,2 S. C. Sealfon1; Bergelson1; 1Division of Infectious Disease, Sierra,1 S. L. Agar,1 M. Burkart,2 T. G. Wood,1 J. 1Department of Neurology and Center for Children's Hospital of Philadelphia, Philadelphia, W. Peterson,1 A. K. Chopra1; 1University of Texas Translational Systems Biology, Mount Sinai School PA, 2Department of Microbiology, University of Medical Branch, Galveston, TX, 2University of of Medicine, New York, NY, 2Department of Pennsylvania, Philadelphia, PA, 3Department of Texas Southwestern Medical School, Dallas, TX Chemical Engineering and Lewis-Sigler Institute for Cell Biology and Physiology, University of Integrative Genomics, Princeton University, Pittsburgh, Pittsburgh, PA 550 B487 Natural Killer Cell Protease Princeton, NJ Granzyme M Targets Alpha-Tubulin and 540 B477 Investigating Coxsackievirus Disorganizes the Microtubule Network. N. Replication Domains: Role of Bovenschen,1 P. J. A. de Koning,1 R. Quadir,1 R. Other Diseases I Phosphotidylinositol 4-kinase Type IIIbeta. N. Broekhuizen,1 J. A. Damen,2 C. J. Froelich,3 M. Hsu, N. Altan-Bonnet; Rutgers University, Newark, Slijper,2 J. Kummer1; 1Department of Pathology, 559 B496 Cholesterol Efflux via ARF6- NJ University Medical Center Utrecht, Utrecht, The regulated Endosomal Recycling Ameliorates the Netherlands, 2Department of Biomolecular Mass Niemann-Pick Type C Disease Phenotype. J. K. 541 B478 Elucidating Mechanisms for Spectrometry, Utrecht University, Utrecht, The Schweitzer, C. D'Souza-Schorey; Biological Overcoming Evolutionary Constraint at a Host- 3 Netherlands, Department of Medicine, Evanston Sciences, University of Notre Dame, Notre Dame, Pathogen Interface Involving Protein Kinase R. Northwestern Healthcare Research Institute, IN N. C. Elde, H. S. Malik; Basic Sciences, Fred Evanston, IL Hutchinson Cancer Research Center, Seattle, WA 560 B497 Defects 551 B488 The HVEM Signaling in in Emery-Dreyfuss Muscular Dystrophy. A. 542 B479 Heparan Sulfate Proteoglycans ␥ 1 2 3 3 Monocytes Is Mediated by PLC 1-dependent Mejat, V. Decostre, A. Kesari, E. Hoffman, G. Facilitate the Macropinocytic Entry of AAV2. C. 1,2 1 Calcium Mobilization. M. Yoon, T. Nguyen, B. Bonne,2 C. L. Stewart,4 T. Misteli1; 1Cell Biology of D. Bess, S. M. Simon; Cellular Biophysics, The 1 1,3 1 Kim, S. Ju ; Biological Sciences, University of Genomes, NIH/NCI, Bethesda, MD, 2G.H. Pitie- Rockefeller University, New York, NY 2 Ulsan, Ulsan, Republic of Korea, Department of Salpetriere, Inserm U582 - Institut de Myologie, Biomedicine, Immunomodulation Research Center, 3 543 B480 Screening and Identification of Paris, France, Research Center for Genetic Ulsan, Republic of Korea, 3Immunomodulation Differentially Expressed Proteins in the Medicine, Children's National Medical Center, Research Center, Ulsan, Republic of Korea 4 Parasitized Diamondback Moth Larva Fat Body. Washington, DC, Institute of Medical Biology, Singapore J. Min Kyo, S. Kyung Han, H. Sung Sik; School of 552 B489 Molecular Interaction between Life Sciences and Biotechnology, Korea University, STIM1 and Orai/CRACM1 at the Plasma 561 B498 Pharmacological Analysis of Seoul, Republic of Korea Membrane Depends on Depletion of Calcium Endogenous Adenosine Receptors in Neuronal Stores. N. T. Calloway,1 M. Vig,2 J. P. Kinet,2 D. Cells Using a Label-free Live-Cell Assay. G. Cell Biology of the Immune System I Holowka,1 B. Baird1; 1Chemistry and Chemical Leung, T. Tutana, R. McGuinness, J. M. Michelotti; Biology, Cornell University, Ithaca, NY, 2Beth Israel- MDS Analytical Technologies, Sunnyvale, CA Deaconess Medical Center, Harvard University, 544 B481 A Distinct Role of Smad7 in TGF- Boston, MA 562 B499 Prion Species Barrier at the ␤ -mediated Anti-Inflammation. Y. Lee, J. Kim, S. Short Phylogenetic Distances in the Yeast Park; Sung Kyun Kwan University, Suwon, 553 B490 Interactions between the Calcium Model. B. Chen, S. Gyoneva, G. P. Newnam, A. V. Republic of Korea Sensor Stim1 and the Ca Channel Orai1 in Romanyuk, Y. O. Chernoff; Biology, Georgia Activated Jurkat T Cells. V. A. Barr,1 K. M. Institute of Technology, Atlanta, GA 545 B482 The Histone Deacetylase Bernot,1 L. Balagopalan,1 S. Srikanth,2 Y. Gwack,2 Inhibitors Phenyl Butyrate and Vitamine B3 D. J. Helman,1 A. Rao,2 L. E. Samelson1; 563 B500 Expression of Nicotinic Yield Distinct Protein Profiles Associated with 1Laboratory of Cellular and Molecular Biology, NCI, Receptors during Stem Cell Differentiation. D. Histone H3 and H4 Modifications during Bethesda, MD, 2Department of Pathology, The Carlisle,1,2 J. Brekosky,2 J. Foley,2 C. Redinger,2 J. Granulocytic Differentiation of HL-60 Cells. V. V. Mich-Basso,2 C. Castro,2 A. Ben-Yehudah,1,2 C. 1,2 2 2 CBR Institute for Biomedical Research, Harvard Borutinskaite, R. Merzvinskyte, G. Treigyte, K. Navara,1,2 G. Schatten1,2; 1Department of Ob/Gyn 1 2 1 Medical School, Boston, MA I. Magnusson, R. Navakauskiene ; Medical and Reproductive Sciences, University of Microbiology, Linkoping University, Linkoping, 554 B491 Dexamethasone Suppresses Pittsburgh, Pittsburgh, PA, 2Pittsburgh 2 Sweden, Developmental Biology, Institute of Activation of Mast Cells by Toll-like Receptor Development Center, Pittsburgh, PA Biochemistry, Vilnius, Lithuania Ligands through Upregulation of SOCS1 and Disruption of the IRAK1/TRAF6/Tak-1 Pathway. 564 B501 IFN␥ Expression Induces 546 B483 Dynamic Imaging in Living Mice H. Qiao, F. Lisboa, M. Beaven; LMI, NHLBI, Splenocyte Trafficking into the CNS. M. Olin; Reveals Effects of the Microenvironment on Bethesda, MD University of Minnesota, St. Paul, MN Leukocyte Migrational Behavior in Inflammation and Tumorigenesis. M. Egeblad,1 A. J. Ewald,1 H. 555 B492 TLR2 Stimulation Enhances 565 B502 Mechanisms of Altered Forebrain A. Askautrud,1 M. L. Truitt,1 G. Peeters,2 Z. Werb1; Activation of NADPH Oxidase p47phox-/--deficient Development in the Ts65Dn Mouse Model of 1Anatomy, University of California, San Francisco, CD8 T Cells. J. A. Wanga, M. Donaldson, A. Down Syndrome. L. Chakrabarti, T. F. Haydar; San Francisco, CA, 2Solamere Technology Group, Wood, S. Jackson; NIAID, National Institutes of Neuroscience Research, Children's National Salt Lake City, UT Health, Bethesda, MD Medical Center, Washington, DC

547 B484 STAT5 and Notch-mediated 556 B493 Cbl-dependent Regulation of LAT- 566 B503 Differences in Aberrant Lineage Commitment in Virtual Lymphocyte nucleated Signaling Complexes. L. Balagopalan, Expression and Splicing of Genes Involved in Models. U. A. Eoff,1 D. Zuercher,1 T. Otter,1 M. A. V. A. Barr, C. L. Sommers, M. Barda-Saad, A. Ca2+ Metabolism between Myotonic Dystrophy Farrar2; 1Crowley Davis Research, Eagle, ID, Goyal, M. E. Isakowitz, L. E. Samelson; National Type 2 (DM2) and Type 1 (DM1). A. Vihola,1 M. 2Laboratory Medicine and Pathology, University of Cancer Institute, National Institutes of Health, Sirito,2 L. L. Bachinski,2 S. E. Olufemi,2 O. Minnesota, Minneapolis, MN Bethesda, MD Raheem,3 T. Suominen,4 B. Udd,1 R. Krahe2; 1Folkhalsan Institute of Genetics, Helsinki, Finland, 548 B485 Generation of a Novel Subset of 557 B494 Estrogen Receptor-binding 2Cancer Genetics, University of Texas M. D. Human NK Regulatory Cells from Peripheral Fragment-associated Antigen 9 (EBAG9) Anderson Cancer Center, Houston, TX, 3Pathology, Blood Progenitors Is Mediated by an Regulates the Cytolytic Capacity of CD8+ T Pirkanmaa Hospital District, Tampere, Finland, Endogenous IL-15 Membrane Bound Form. B. Lymphocytes through Control of Lytic Granule 4Neurogenetics, University of Tampere, Tampere, Azzarone; Inserm U 542, Villejuif, France Release. C. Rüder,1 U. E. Höpken,2 B. Engels,2 W. Finland Uckert,2 B. Dörken,2 A. Rehm1; 1Department of Hematology, Oncology, and Tumor Immunology, Max-Delbrück-Center for Molecular Medicine, Berlin, Germany, 2Max-Delbrück-Center for Molecular Medicine, Berlin, Germany

71 SUNDAY The American Society for Cell Biology 47th Annual Meeting Poster Session 1 B504–B529 December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org

567 B504 Abnormal Expression of DMPK Cancer I 584 B521 Roles of hREV3 in Cell Substrate Phospholamban in DM2. O. Raheem,1 Proliferation in Response to DNA Damage. X. J. Holmlund-Hampf,2 T. Suominen,3 A. Vihola,2 H. Fang, L. Yuanjie, J. Caixia; Department of Biology, 575 B512 Deciphering Breast Cancer Haapasalo,1 R. Krahe,4 B. Udd2; 1Pathology, NingXia Medical College in China, Yingchuan Metastasis Using Protein Networks. H. Chuang,1 Pirkanmaa Hospital District, Center for Laboratory Ningxia, China E. Lee,2 D. Lee,2 T. Ideker3; 1Bioinformatics, Medicine, Tampere, Finland, 2Medical Genetics, University of California, San Diego, San Diego, CA, University of Helsinki and Folkhälsan Institute of 585 B522 Coexpression of Tumor 2BioSystems, Korea Advanced Institute of Science Genetics, Helsinki, Finland, 3Neurogenetics, Suppressor Menin Can Inhibit Islet Cell and Technology, Daejeon, Republic of Korea, 1 University of Tampere, Tampere, Finland, 4Section Transformation Driven by Tumor Virus. J. Yan, 3Bioengineering, University of California, San 1 2 3 4 of Cancer Genetics, Department of Molecular C. King, R. Hovhannisyan, E. Blagoi, J. Zhao, Diego, San Diego, CA 3 2 1 1 Genetics, University of Texas M. D. Anderson C. Yuan, R. P. Carstens, X. Hua ; Abramson Family Cancer Research Institute and Department Cancer Center, Houston, TX 576 B513 Multimarker Immunomagnetic of Cancer Biology, University of Pennsylvania, Enrichment and Detection of Circulating Tumor 568 B505 GSTT1 as an Aging Marker in Philadelphia, PA, 2Genetics and Gene Regulation Cells in the Peripheral Blood of Patients with Granulosa Cells. M. Muraki,1 T. Kono,2 H. Saito,1 Program, University of Pennsylvania, Philadelphia, Metastatic Breast Cancer. G. Y. Deng,1 D. Y. Takahashi1; 1Department of Perinatal Medicine PA, 3Proteomics Core Facility, University of Burgess,1 E. A. Manna,2 D. Krag,3 J. Burke,4 M. and Maternal Care, National Center for Child Pennsylvania, Philadelphia, PA, 4Biomedical Herrler1; 1Applied Imaging Corp. - A Genetix Health and Development, Tokyo, Japan, Imaging Core, University of Pennsylvania, Company, San Jose, CA, 2University of Vermont, 2Department of Bioscience, Tokyo University of Philadelphia, PA College of Medicine, Burlington, VT, 3University of Agriculture, Tokyo, Japan Vermont, College of Medicine, San Jose, CA, 586 B523 IGF-1 Expression Is Silenced in 4 569 B506 Increased Cellular Mechanical Genetix, New Milton, United Kingdom Senescent and Aged Fibroblasts Resulting in Sensitivity in Hutchinson-Gilford Progeria an Altered Keratinocyte Response to UVB- 577 B514 Role of Stem Cell Transcriptional Syndrome. V. L. R. Verstraeten, J. Y. Ji, R. T. Lee, Irradiation. D. Lewis,1 D. Spandau2; 1Dermatology, Regulators in Breast Cancer Progression. Y. J. Lammerding; Medicine, Brigham & Women's Indiana University School of Medicine, Indianapolis, Soignier, E. Dunham, G. Martin; Molecular and Cell Hospital, Harvard Medical School, Cambridge, MA IN, 2Dermatology and Biochemistry, Indiana Biology, University of California, Berkeley, Berkeley, University School of Medicine, Indianapolis, IN 570 B507 Accelerated Senescence in CA Degenerate Intervertebral Disc of Laminopathy- 587 B524 An In Vivo Screen for Radiation 578 B515 Evidence for a Tumorigenic based Premature Aging Mouse Model. J. Li,1 Y. Sensitizers in Drosophila melanogaster. M. Multipotent Cell in erbB2 Mammary Wu,2 E. Wu,2 D. Chan,1 K. Cheah,1 Z. Zhou1; Stewart, T. Su; MCD Biology, University of Carcinomas. B. W. Booth, C. A. Boulanger, G. H. 1Biochemistry, The University of Hong Kong, Hong Colorado Boulder, Boulder, CO Smith; MBTL, NIH/NCI, Bethesda, MD Kong, 2Electrical and Electronic Engineering, The 588 B525 Id2 Is a Key Regulator of Aerobic University of Hong Kong, Hong Kong 579 B516 Spontaneous Transformation of Glycolysis. J. M. Murad, N. P. Watson, M. A. Human Granulosa Cell Tumor into Aggressive 571 B508 Identification of TPO1 in Yeast, Israel; Department of Genetics and Pediatrics, Phenotype. M. Imai,1 M. Seiki,2 H. Saito,1 Y. and Its Human Orthologue TETRAN, a Novel Norris Cotton Cancer Center, Dartmouth Medical Takahashi1; 1Department of Perinatal Medicine and Transporter for Non-steroidal Anti-Inflammatory School, Lebanon, NH Maternal Care, National Center for Child Health Drugs and Other Anionic Drugs. H. Ushijima,1 Y. and Development, Tokyo, Japan, 2The Institute of Moriyama,2 T. Mizushima1; 1Graduate School of 589 B526 WITHDRAWN Medical Science, The University of Tokyo, Tokyo, Medical and Pharmaceutical Sciences, Kumamoto Japan 590 B527 PKC␦-driven Midkine Expression University, Kumamoto, Japan, 2Graduate School of Acts as an Autocrine Factor for the Growth of Medicine, Density and Pharmaceutical Sciences, 580 B517 Immunohistochemical and mRNA Human Non-Small Cell Lung Cancer Selectively Okayama University, Okayama, Japan Expression Analysis of Lymphoma Associated in the Hypoxic Microenvironments. M. with Breast Milk Transmission of a Retrovirus 1 2 2 572 B509 Mesenchymal Stem Cells from Okamoto, A. M. Poczobutt, W. M. Zawada, M. in a Mouse Model. H. Bagalb,1 H. Okonta,1 J. 1 1 Human Umbilical Cord Blood Differentiate into Das ; Pediatrics, University of Colorado Health Duggan,2 J. Chakraborty1; 1Physiology and 2 Respiratory Epithelial Cells. Y. Bae, H. Jin, W. Sciences Center, Denver, CO, Medicine, Pharmacology, University of Toledo Health Science Oh, Y. Yang, S. Choi; MEDIPOST Co, Ltd., Seoul, University of Colorado Health Sciences Center, Campus, Toledo, OH, 2Medicine, University of Republic of Korea Denver, CO Toledo Health Science Campus, Toledo, OH 573 B510 Defining the Mechanisms of 591 B528 Changes in Expression of Heat 581 B518 The Human Papillomavirus 16 E6 Paralogue Specific SUMO Conjugation: Shock Protein 60 under Dehydrated Condition. and E7 Oncoproteins: Induction of Genomic Analysis of the Bloom’s Syndrome DNA H. Lee, M. Kim, C. Lee, D. Kim, Y. Hwang; Division Instability Damage and Cellular Sequelae. E. M. Helicase (BLM). J. Zhu, M. J. Matunis; of Biological Science, Gachon University of McGhee,1 A. Baldwin,2 K. Munger2; 1University of Biochemistry and Molecular Biology, Johns Hopkins Medicine & Science, Incheon, Republic of Korea California, San Francisco, San Francisco, CA, University Bloomberg School of Public Health, 2Brigham and Women's Hospital–Channing 592 B529 KCl Cotransporter KCC3 Baltimore, MD Laboratory, Harvard Medical School, Boston, MA Downregulates E-cadherin/Beta-Catenin 574 B511 Phosphatidic Acid Metabolism Complex Formation to Promote Epithelial- 582 B519 NRIP (Nuclear Receptor 1 1 Regulates the Intracellular Trafficking of CFTR. Mesenchymal Transition. Y. Hsu, C. Yih-Fung, Interaction Protein) Is Essential but Not 2 3 4 S. Mizunoe,1 Y. Hashimoto,1 T. Okiyoneda,1 K. C. Cheng-Yang, T. Ming-Jer, C. Ji Hshiung, R. Necessary for Glucocorticoid Receptor- 5 5 6 1 Harada,1 K. Ueno,1 T. Sugahara,1 A. Yamashita,2 Wilkins, J. Ellory, M. Shen ; Basic Medical mediated Human Papillomavirus 16 Gene T. Shuto,1 M. Suico,1 H. Kai1; 1Molecular Medicine, Science, National Cheng Kung University, Tainan, Expression. S. Chang,1 J. Guo,1 Y. Tsao,2 P. Lu,1 2 Graduate School of Pharmaceutical Sciences, Taiwan, Department of Obstetrics & Gynecology, Y. Cheng,3 S. Chen1; 1Graduate Institute of Kumamoto University, Kumamoto, Japan, 2Faculty National Cheng Kung University, Tainan, Taiwan, Microbiology, National Taiwan University, Taipei, 3Physiology, National Cheng Kung University, of Pharmaceutical Sciences, Teikyo University 2 Taiwan, Department of Ophthalmology, Mackay Tainan, Taiwan, 4Graduate Institute of Molecular Sagamiko, Sagamihara, Japan 3 Memorial Hospital, Taipei, Taiwan, Department of and Cell Biology, Tzu Chi University, Hualien, Medicine, Chung Shan Medical University, Taiwan, 5Department of Physiology, Anatomy and Taichung, Taiwan Genetics, University of Oxford, Oxford, United Kingdom, 6Pharmacology, National Cheng Kung 583 B520 Human Papillomavirus 16 E5 University, Tainan, Taiwan Induces by Cell Fusion. B. P. Ceresa, L. Hu; Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK

72 The American Society for Cell Biology 47th Annual Meeting SUNDAY December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org Poster Session 1 B530–B561

593 B530 Midkine and LRP1 Are Involved 602 B540 Catalytically-inactive SHIP2 613 B551 Activation and Inhibition of ALK in Anchorage-independent Growth of Cancer Inhibits Preadipocyte Proliferation and PDGF Receptor Tyrosine Kinase by Monoclonal Cells. S. Chen,1 G. Bu,2 Y. Takei,1 K. Sakamoto,1 Signaling. Y. Artemenko,1,2 A. Gagnon,1,2 A. Antibodies. J. Degoutin,1 J. Y. Gouzi,2 N. Brunet T. Muramatsu,3 K. Kadomatsu1; 1Department of Sorisky1,2; 1Ottawa Health Research Institute, De Carvalho,1 C. Cifuentes-Diaz,1 M. Vigny1; 1IFM Biochemistry, Nagoya University, Nagoya, Japan, Ottawa, ON, Canada, 2University of Ottawa, INSERM UMR-S 839/UPMC, Paris, France, 2BSRC 2Department of Pediatrics and Cell Biology and Ottawa, ON, Canada 'Alexander Fleming', Vari, Hellas, Greece Physiology, Washington University, St Louis, MO, 3Department of Health Science, Aichi Gakuin 603 B541 Key Regulatory Roles of Akt 1 University, Nisshin, Japan Isoform in Adipocyte Differentiation. S. Yun, D. Cell Cycle Controls I Tucker,2 K. Roovers,2 E. Kim,1 M. Kim,1 K. Do,1 C. 594 B531 Loss of 4.1N Is Correlated to Cell Kim,1 M. Birnbaum,2 S. Bae1; 1Pharmacology, 614 B552 Cell Cycle-related Genes’ Differentiation in Colon Cancer. Q. Kang,1,2 Y. MRCITR and Pusan National University School of Pathway in Liver Regeneration and Qi,2 W. Feng,2 N. Mohandas,1 X. An1; 1Red Cell Medicine, Busan, Republic of Korea, 2Department Organogenesis. J. Keum, Y. Lee, S. Kim, D. Kim, Physiology Laboratory, New York Blood Center, of Medicine, Howard Hughes Medical Institute, Y. Hwang; Division of Biological Science, Gachon New York, NY, 2Bioengineering Department, Philadelphia, PA University of Medicine & Science, Incheon, Zhengzhou University, Zhengzhou, China Republic of Korea 604 B542 Antagonistic Interactions 595 B532 Hyperparathyroidism and High between the Retinoic Acid Receptor and Ras/ 615 B553 Cell Cycle Regulatory Proteins Incidence of Parathyroid Malignancy in Protein ERK Signaling Pathways in Affected by Androgens in Epithelial Cells of the 4.1R Knockout Mice. X. An, C. Liu, S. Yang, G. Cells. M. Imajo, K. Kondoh, T. Yamamoto, K. Aging Brown-Norway Rat Prostate. J. Yan, T. R. Debnath, L. Wu, N. Mohandas; Red Cell Nakayama, E. Nishida; Department of Cell and Brown; Biochemistry & Molecular Biology, Johns Physiology Laboratory, The New York Blood Developmental Biology, Graduate School of Hopkins Bloomberg School of Public Health, Center, New York, NY Biostudies, Kyoto University, Kyoto, Japan Baltimore, MD

596 B533 Coronin-1C and Coactosin 605 B543 Primary Rat Adrenal Cells’ 616 B554 Cyclin B Functional Regulate Actin Dynamics during Metastasis. D. Signaling Pathways and Proliferation-Death Characterization and Endopolyploidization in W. Roadcap,1 D. Zedek,2 P. Groben,2 A. Responses to ACTH and FGF2. G. E. Mattos, C. Phalaenopsis bellina. Y. Kao, W. Wei, W. Chen; Lachiewicz,2 N. Holoweckyj,1 N. Thomas,2 J. E. F. P. Lotfi; Anatomy, Institute of Biomedical Department of Life Science, National University of Bear1; 1Lineberger Cancer Center, University of Science, São Paulo, Brazil Kaohsiung, Kaohsiung, Taiwan North Carolina, Chapel Hill, NC, 2Dermatology, University of North Carolina, Chapel Hill, NC 606 B544 Involvement of MKP-1 in the 617 B555 Neuropeptide Y (NPY) Induces Regulation of p38 upon Contact Inhibition in Endoreplication via Y5 Receptors. C. Lu,1 K. 597 B534 Lysyl Oxidase Like Enzymes Are Fibroblasts. M. Slisz, K. Jackson, D. Hutter; Creswell,1 K. Abe,1 J. Pons,2 L. Everhart,1 M. Differentially Expressed in Cancers Involving Biology, Monmouth University, West Long Branch, Lombard,1 Z. Zukowska,1 J. Kitlinska1; the Serosal Cavities. S. Sebban,1 B. Davidson,2 NJ 1Georgetown University, Washington, DC, R. Reich1; 1Pharmacology, Hebrew University, 2University of California, San Francisco, San 2 607 B545 Growth Factor Receptor or ERK Jerusalem, Israel, Pathology Clinic, Rikshospitalet- Francisco, CA Radiumhospitalet Medical Center, Oslo, Norway MAP Kinase Inhibition Rescues Dysfunctional 3D-Mammary Epithelial Acinus Assembly. F. 618 B556 The Identification of Esp1p Martin, E. McArdle, E. Gilligan, L. Thornton, J. Regulators Using a Suppressor Screen. L. Signal Transduction I Murtagh; Pharmacology, Conway Institute, Dublin, Barbour, O. Cohen-Fix; Laboratory of Molecular Ireland and Cellular Biology, NIDDK, National Institutes of 598 B536 Hyaluronan Binding Protein 1 Health, Bethesda, MD 608 B546 Effect of P38MAPK on Filopodial (HABP1/p32/gC1qR) Upregulation and Nuclear Formation in KG1a Human Hematopoietic Cell Translocation Is Associated with Muscle 619 B557 Regulation of Centriole Line. P. L. Patel; Cell Biology and Biotechnology, Differentiation. V. Rai, K. Datta; Cellular and Duplication in Mammalian Cells Polo-like University of Sciences in Philadelphia, Philadelphia, Molecular Biology, S.E.S., Jawaharlal Nehru Kinase-2. I. Hoffmann, O. Cizmecioglu, S. Warnke; PA University, New Delhi, India DKFZ, Heidelberg, Germany 609 B547 The Requirement for hVps34 in 599 B537 Characterizing the Inhibitory 620 B558 SZY-20, a Novel RNA-Binding mTOR/S6K1 Signaling Is Unrelated to hVps34’s 1 Mechanisms of OSU-03012 on Vascular Smooth Protein, Limits Centrosome Size. M. Song, A. Role in Endosomal Trafficking. R. J. Flinn, J. M. 2 1 1 Muscle Cell Proliferation. C. J. Wu, C. Wen, J. Iyer, K. F. O'Connell ; NIH/NIDDK, Bethesda, Backer; Molecular Pharmacology, Albert Einstein 2 Weng; Biological Science and Tehcnology, China MD, NIH/NCBI/NLM, Bethesda, MD College of Medicine, Bronx, NY Medical University, Taichung, Taiwan 621 B559 Control of Centrin Stability by 610 B548 Role of Ppq1 Phosphatase in the 600 B538 Cdk5 Inhibitory Peptide (CIP) Aurora A Is a Mechanism Driving Centrosome Mating MAP Kinase Pathway in Yeast. E. Shim, 1 Specifically Inhibits Cdk5/p25 Activity and Amplification in Cancer. K. B. Lukasiewicz, T. M. P. Sang-Hyun; Seoul National University, Seoul, 2 2 1 Regulates Insulin Secretion in Pancreatic Beta Greenwood, J. L. Salisbury, W. L. Lingle ; Republic of Korea 1 Cells. Y. Zheng,1 Y. Hu,2 A. Zhang,2 P. Grant,1 A. Experimental Pathology, Mayo Clinic, Rochester, 2 2 1 1 MN, Biochemistry and Molecular Biology, Mayo Notkins, H. C. Pant ; NINDS/LNC, National 611 B549 The Plasma Membrane Shuttling Clinic, Rochester, MN Institutes of Health NIH/NINDS, Bethesda, MD, of Ca2+-promoted Ras Inactivator (CAPRI) Is 2NIDCR/OIIB, National Institutes of Health NIH/ Related to Regulation of Mast Cell Activation. T. 622 B560 The Spindle Assembly NIDCR, Bethesda, MD Furuno, R. Nakamura, M. Nakanishi; School of Checkpoint Regulates Post Mitotic Nuclear Pore Pharmacy, Aichi Gakuin University, Nagoya, Japan 601 B539 Glucosamine Treatment-mediated Complex Reformation in Aspergillus nidulans. C. P. De Souza, T. Nayak, S. Hashmi, B. R. O-Glycosylation on Ser473 of Akt Controls 612 B550 Different Isoforms of the Type I 1 2 Oakley, S. A. Osmani; Molecular Genetics, Ohio Pancreatic ␤ Cell Death. E. Kang, J. Park, S. Phosphatidylinositol 4-phosphate 5-kinase May 1 3 4 1 State University, Columbus, OH Lee, Y. Kim, J. Lee ; Department of Molecular Regulate Different Pools of Phosphatidylinositol and Clinical Oncology, Cancer Research Institute, 4,5-bisphosphate in RBL-2H3 Mast Cells. L. 623 B561 Phosphorylation of the Budding College of Medicine, Seoul National University, 1 2 3 3 Vasudevan, A. Jeromin, B. Baird, D. Holowka ; Yeast Spindle Pole Body Component Spc29p Is Seoul, Republic of Korea, 2Cancer Research 1 Molecular Biology and Genetics, Cornell Required for Proper Duplication of Spindle Pole Institute, College of Medicine, Seoul National 2 University, Ithaca, NY, Center for Learning and Bodies. E. P. Holinger,1 W. M. Old,2 T. H. 3Department University, Seoul, Republic of Korea, Memory, University of Texas, Austin, TX, Giddings,1 M. Winey1; 1MCD Biology, University of of Tumor Biology, Cancer Research Institute, 3Chemistry and Chemical Biology, Cornell Colorado, Boulder, CO, 2Chemistry and College of Medicine, Seoul National University, University, Ithaca, NY Biochemistry, University of Colorado, Boulder, CO Seoul, Republic of Korea, 4Departments of Tumor Biology and Molecular and Clinical Oncology, Cancer Research Institute, College of Medicine, Seoul National University, Seoul, Republic of Korea

73 SUNDAY The American Society for Cell Biology 47th Annual Meeting Poster Session 1 B562–B594 December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org

624 B562 Apq12p: A Novel Cell Cycle 635 B573 Mechanisms of Acentriolar 646 B584 Two Nuclear Pore Complex Regulator in Saccharomyces cerevisiae. P. Spindle Formation and Chromosome Alignment Proteins in Aspergillus, Which Were Thought to Fearon, O. Cohen-Fix; LMCB, NIDDK, NIH, during C. elegans Oocyte Meiosis. S. M. Wignall, Be Unique to Vertebrates, Have a Mitotic Bethesda, MD A. M. Villeneuve; Developmental Biology, Stanford Specific Function. H. Liu, S. A. Osmani; University, Stanford, CA Molecular Genetics, The Ohio State University, 625 B563 Multinucleated and Micronucleus Columbus, OH Biological Meaning in Vincristine Treatments. G. 636 B574 Localization and Dynamics of M. Machado-Santelli,1 E. Nakagawa,2 V. M. Dias2; Filamentous Actin in Nuclei Isolated from 647 B585 Nuclear Characterization of 1Cell and Development Biology, University of Sao Spisula Oocytes. J. Larkin, T. Potapova, D. Eccrinales [Opisthokonta: Mesomycetozoa] Paulo, ICB, Sao Paulo, Brazil, 2Biology, University Mullins; Physiology Course, Marine Biological through Fluorescence. S. Acevedo Mendez,1 J. of Sao Paulo, IB, Sao Paulo, Brazil Laboratory, Woods Hole, MA Hernandez Roa,2 M. J. Cafaro2; 1Department of Natural Sciences, University of Puerto Rico, ␥ 626 B564 -Tubulin Affects Cell-Cycle 637 B575 Anaphase B-related Microtubule Aguadilla, PR, 2Department of Biology, University Regulation by Modulating the Activity of the Flux Outside the Spindle during Crane-fly of Puerto Rico, Mayaguez, PR Anaphase Promoting Complex. T. Nayak, B. R. Meiosis. J. R. LaFountain,1 C. Cohan,2 R. Oakley; Molecular Genetics, The Ohio State Oldenbourg3; 1Biological Sciences, University at 648 B586 The Role of Cohesion University, Columbus, OH Buffalo, Buffalo, NY, 2Pathology and Anatomy, Establishment in Genomic Maintenance. M. E. University at Buffalo, Buffalo, NY, 3Marine Maradeo, B. Satish, S. V. Robert; Biological 627 B565 Localization and Initial Biological Laboratory, Woods Hole, MA Sciences, Lehigh University, Bethlehem, PA Phenotypic Analysis of Three Mitotic Regulatory Proteins of Aspergillus nidulans. H. 638 B576 Whole Transcriptome Analysis of 649 B587 Mechanisms of Mammalian Polo- D. Edgerton, T. Nayak, E. Szewczyk, C. E. Oakley, Coprinus cinereus Meiotic Development. C. like Kinase 1 (Plk1) Localization: Self- versus B. R. Oakley; Molecular Genetics, The Ohio State Burns,1 J. E. Stajich,2 J. D. Lieb,3 S. E. Hanlon,3 Non-Self-priming. J. Park,1 Y. Kang,1 R. Erikson,2 University, Columbus, OH W. W. Lilly,4 A. C. Gathman,4 S. K. Wilke,3 M. E. K. S. Lee1; 1National Cancer Institute, NIH, Zolan,1 P. J. Pukkila5; 1Biology, Indiana University, Bethesda, MD, 2Harvard University, Cambridge, 628 B566 Defining the Role of a Fission Bloomington, IN, 2Plant and Microbial Biology, MA Yeast DNA Checkpoint Protein during University of California, Berkeley, CA, 3Biology, Microtubule Stress. M. Herring, T. Wolkow; University of North Carolina at Chapel Hill, Chapel 650 B588 Endocytic Adaptor Protein University of Colorado at Colorado Springs, Hill, NC, 4Biology, Southeast Missouri State Epsin1 Plays a Role in Mitosis. Z. Liu, Y. Zheng; Colorado Springs, CO University, Cape Girardeau, MO, 5University of Department of Embryology, Carnegie Institution of North Carolina at Chapel Hill, Chapel Hill, NC Washington, Baltimore, MD 629 B567 Nuclear Export of the Swi6 Transcription Factor Is Regulated by at Least 639 B577 Molecular Characterization of 651 B589 The Spindle Matrix Complex Two Karyopherins in S. cerevisiae. M. Pettit, K. Environmentally Induced Parthenogenetic Protein, Chromator, Is Required for Proper Kokanovich, W. Yewdell, M. Barber, N. Hussain, E. Meiosis in the Pea Aphid Acyrthosiphon pisum. Microtubule Spindle Formation and Mitosis in Damuth, K. D. Belanger; Biology, Colgate D. G. Srinivasan, G. K. Davis, D. L. Stern; Ecology Drosophila Neuroblasts. Y. Ding, U. Rath, H. Qi, University, Hamilton, NY and Evolutionary Biology, Princeton University, L. Zhu, J. Girton, J. Johansen, K. M. Johansen; Princeton, NJ Biochemistry, Biophysics & Molecular Biology, Iowa 630 B568 A Novel Cyclin-dependent Kinase State University, Ames, IA Mediates Cell Size Checkpoint Control through 640 B578 Functional Genomic Screen the Retinoblastoma (RB) Tumor Suppressor Defines Multiple Pathways for Clustering 652 B590 Cdc42 and PAK2 Control the Pathway in Chlamydomonas. J. G. Umen, G. Supernumerary Centrosomes. M. Kwon, S. A. Mitotic Spindle Orientation in Mammalian Cells. Anderson, Y. Li; Plant Biology Laboratory, The Salk Godinho, N. S. Chandhok, D. Pellman; Pediatric M. Mitsushima, T. Fumiko, N. Eisuke; Cell and Institute, La Jolla, CA Oncology, Dana-Farber Cancer Institute, Boston, Developmental Biology, Kyoto University, Kyoto, MA Japan

Mitosis and Meiosis I 641 B579 Do Centrioles or Pericentriolar Material Inhibit Poleward Flux during Mitosis? Cytokinesis I 631 B569 Ultrastructural Characterization D. W. Buster, D. Zhang, D. J. Sharp; Physiology of Mitotic Germline Cells in Caenorhabditis and Biophysics, Albert Einstein College of 653 B591 The Plus Ends of Microtubules elegans. S. Cai,1,2 L. Keller,3,2 G. Greenan,4,2 A. Medicine, Bronx, NY Determine the Cell Division Plane through Rho- Hyman,4,2 T. Muller-Reichert4,2; 1Indiana University, mediated Signaling. K. Kamijo,1 M. Abe,2 T. Bloomington, IN, 2Physiology Course, Marine 642 B580 The Subcellular Localization of ␤- Kobayashi,2 Y. Nishimura,3 S. Yonemura3; Biological Laboratory, Woods Hole, MA, 3University catenin during Cell-Cycle in Normal or 1Anatomy and Cell Biology, Fujita Health University, of California, San Francisco, San Francisco, CA, Transformed Cells. P. Huang, T. Senga, M. Toyoake-shi, Japan, 2Lipid Biology Laboratory, 4Max Planck Institute of Molecular Cell Biology and Hamaguchi; Oncology, Nagoya University Graduate RIKEN, Wako-shi, Japan, 3Electron Microscope Genetics, Dresden, Germany School of Medicine, Nagoya, Japan Laboratory, RIKEN, Kobe-shi, Japan

632 B570 Mutagenesis of SLK19 to Create 643 B581 Live-Cell Analysis of Mitosis in 654 B592 Functional Interaction between Temperature Sensitive Mutations in Vinblastine-treated Cells. K. Trimble, J. Hornick, Citron Kinase and Anillin in Cytokinesis. M. Saccharomyces cerevisiae. L. Lasher, C. R. E. S. Halpin, E. H. Hinchcliffe; Biological Sciences, Gai,1 P. Camera,1 G. Berto,1 F. Bianchi,1 C. Field,2 Davis; Biology, Roberts Wesleyan College, University of Notre Dame, Notre Dame, IN F. Di Cunto1; 1MBC, University of Torino, Torino, Rochester, NY Italy, 2Department of Systems Biology, Harvard 644 B582 Why Mitosis Is Prolonged in Medical School, Boston, MA 633 B571 Microtubule Flux in Kinetochore Cultures of Cancer and Transformed Cells. Z. Fibers (K-Fibers) of Anaphase Lagging Yang,1 J. Loncarek,1 C. Rieder1,2; 1Wadsworth 655 B593 Novel Role of the Endocytic Univalents during Meiosis I. M. A. Janicke,1 C. Center, Albany, NY, 2Department of Biomedical Adaptor Epsin-2 in Cytokinesis Regulation. D. Cohan,2 J. R. LaFountain1; 1Biological Sciences, Sciences, State University of New York, Albany, NY Mukherjee,1 B. G. Coon,1 S. A. Longhi,2,3 B. R. SUNY at Buffalo, Amherst, NY, 2Anatomy and Cell Wendland,2 L. A. Retegui,3 R. C. Aguilar1; 645 B583 Spindle Assembly Mechanisms Biology, SUNY at Buffalo, Buffalo, NY 1Biological Sciences, Purdue University, West and Checkpoints: Insight from Human Cells Lafayette, IN, 2Biology, Johns Hopkins University, Undergoing Mitosis with an Unreplicated 634 B572 Conditional C. elegans Mutants Baltimore, MD, 3Quimica Biologica, Universidad de Genome (MUG). C. B. O'Connell, J. Loncarek, P. with Defects in Meiotic Spindle Assembly and Buenos Aires, Buenos Aires, Argentina . M. H. Price, B. Hergert, A. Khodjakov; Wadsworth Center, N.Y.S. Bowerman; Institute of Molecular Biology, Department of Health, Albany, NY 656 B594 MgcRacGAP Promotes GTPase University of Oregon, Eugene, OR Flux to Maintain a Tightly Focused Zone of Rho Activity during Cytokinesis. A. L. Miller, W. M. Bement; Zoology, University of Wisconsin–Madison, Madison, WI

74 The American Society for Cell Biology 47th Annual Meeting SUNDAY December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org Poster Session 1 B595–B621

657 B595 TIRF Analysis of Pavarotti 667 B605 The Clp1/Cdc14 Phosphatase 675 B613 Cell Death Induced by a Novel Kinesin Accumulation Along Cortical Contributes to the Robustness of Fission Yeast Compound, Disorazole C1. F. Xu,1 P. Wipf,2 J. Microtubules during Cytokinesis. E. R. Griffis,1 Cytokinesis through Association with Anillin- Lazo,3 K. Kiselyov,1 W. Saunders1; 1Biological R. D. Vale2; 1CMP, HHMI/University of California, related Mid1. D. M. Clifford Hart,1 B. A. Wolfe,1 R. Sciences, University of Pittsburgh, Pittsburgh, PA, San Francisco, San Francisco, CA, 2Physiology H. Roberts-Galbraith,1 W. H. McDonald,2 J. R. 2Chemistry, University of Pittsburgh, Pittsburgh, PA, Course, Marine Biology Laboratory, Woods Hole, Yates,2 K. L. Gould1; 1Cell and Developmental 3Pharmacology, University of Pittsburgh, Pittsburgh, MA Biology, Vanderbilt University Medical School & PA HHMI, Nashville, TN, 2Cell Biology, Scripps 658 B596 A New Mechanism Protecting Research Institute, San Diego, CA 676 B614 Transcription Factor Max Is a Cells against Tetraploidization. P. Steigemann, Major Player of Programmed Cell Death in the M. Schmitz, M. Held, J. Guizetti, S. Maar, D. W. 668 B606 Myo1p, the Sole Type II Myosin in Central Nervous System. R. Linden,1 H. Petrs- Gerlich; Institute of Biochemistry, ETH Zurich, Saccharomyces cerevisiae, Is a Dimer and Silva,1 L. B. Chiarini,1 V. Chiodo,2 W. W. Zurich, Switzerland Targets to the Division Site via Interactions with Hauswirth2; 1Laboratory of Neurogenesis, Instituto the Septins. J. Luo,1 X. Fang,1 E. A. Vallen,2 C. de Biofisica da UFRJ, Rio de Janeiro, Brazil, 659 B597 Myosin Light Chain Kinase Dravis,1 M. Travaglia,1 M. Iwase,1 C. Franzini- 2University of Florida, Gainesville, FL Inhibition and Cytokinesis Failure in Cancer Armstrong,1 E. Bi1; 1Department of Cell/ Cells. R. M. Sahasrabudhe, Q. Wu, W. Saunders; Developmental Biology, University of Pennsylvania 677 B615 Rho5 GTPase Is Necessary for Biological Sciences, University of Pittsburgh, School of Medicine, Philadelphia, PA, 2Department Oxidant-induced Cell Death in Budding Yeast. Pittsburgh, PA of Biology, Swarthmore College, Swarthmore, PA H. Park, K. Singh, P. Kang; The Ohio State University, Columbus, OH 660 B598 Phopho-Regulation of Non- Muscle Myosin II during Cell Division. J. Beach, Apoptosis 678 B616 The Roles of EGFR, MAP, and Akt T. Egelhoff; Case Western Reserve University, Kinases and Transcription Factor AP-1 in Cleveland, OH Radiation-induced Cell Death in Prostate 669 B607 Genetically Encoded Reporters Cancer Cell Lines PC-3 and DU 145. R. M. A. for Caspase Activity in Live Single Cells. P. D. 661 B599 Distribution and Recruitment of Kajanne,1 P. J. Miettinen,2 S. Leppa3; 1Molecular Bhola, S. M. Simon; The Rockefeller University, Myosin Regulatory Light Chain during and Cancer Research Program, University of New York, NY Assembly of the Contractile Ring during Helsinki, Helsinki, Finland, 2Hospital for Children Cytokinesis in Epithelial Cells. K. Murthy, C. 670 B608 Imaging the Release of and Adolescents, Helsinki University Central Fagerstrom, P. Wadsworth; Biology Department, 3 Cytochrome C from Individual Mitochondria in a Hospital, Helsinki, Finland, Department of University of Massachusetts, Amherst, Amherst, Single Cell. A. L. Mattheyses, P. D. Bhola, S. M. Oncology, Helsinki University Central Hospital, MA Simon; Cellular Biophysics, The Rockefeller Helsinki, Finland University, New York, NY 662 B600 Deficiency in Phosphorylation of 679 B617 Interaction between Insulin-like Myosin Light Chain Is a Cause of Cytokinesis 671 B609 A Novel Assay to Screen for Growth Factor Binding Protein-6 (IGFP-6) and Failure in Cancer Cells. Q. Wu, W. S. Saunders; Adhesion Proteins Involved in Programmed Cell Nuclear Factor IV (Ku80): A Novel Functional Department of Biological Sciences, University of Death in C. elegans. G. Shemer, B. Goldstein; Mechanism of a Growth Inhibitory Protein in Pittsburgh, Pittsburgh, PA University of North Carolina–Chapel Hill, Chapel Cell Fate Regulation. C. Iosef, G. Vilk, S. Li, V. K. Han; Paediatrics, The University of Western 663 B601 Identification of Novel Inhibitors Hill, NC Ontario, London, ON, Canada of Cellular Wound Healing and Cytokinesis. A. 672 B610 Induction of Cell Death by G. Clark,1 J. R. Sider,2 W. M. Bement1,2; 1Zoology, Anoikis in Retinal Pericytes by the Matricellular 680 B618 Induction of Apoptosis in HL-60 University of Wisconsin–Madison, Madison, WI, Proteins Cyr61 and CTGF. H. Liu, R. Yang, A. Cells by PGA2 through Intrinsic Mitochondrial 2Center for Cell Dynamics, University of Chowdhry, B. Chaqour; Department of Anatomy Apoptotic Pathway. J. Kim, S. Lee, K. Ko, H. Kim; Washington at Friday Harbor Labs, Friday Harbor, and Cell Biology, SUNY Downstate Medical Center, Department of Biochemistry, College of Medicine, WA Brooklyn, NY The Catholic University of Korea, Seoul, Republic 664 B602 Towards Combinatorial Chemical of Korea 673 B611 Apicularen A-induced and Genetic Approaches of Dissecting Cytotoxicity Is Augmented by Protein Kinase C 681 B619 Amplification of the Molecular Pathways That Regulate Cytokinesis Activation in HeLa Cells. K. Seo,1 J. Kim,1 K. Mitochondrial Apoptotic Pathway by Reactive in Dictyostelium. Q. Zhou, M. E. Tran, S. Divi, S. Song,1 E. Yun,1 J. Heo,1 J. Park,1 K. Jing,1 Y. Oxygen Species. E. Kim, H. Yang, S. Kang, H. S. Willard, P. N. Devreotes, D. N. Robinson; Jung,1 J. Park,1,2 G. Kweon,1,2,2 S. Park,1,2 W. Um; Laboratory of Radiation Tumor Physiology, Department of Cell Biology, Johns Hopkins Yoon,1 K. Lim,1,3 B. Hwang1,2; 1Department of Korea Institute of Radiological & Medical Sciences, University School of Medicine, Baltimore, MD Biochemistry, College of Medicine, Chungnam Seoul, Republic of Korea National University, Daejeon, Republic of Korea, 665 B603 Crosstalk between the SIN and 682 B620 Atypical Mode of Cell Death 2Research Institute for Medical Science, Chungnam MOR NDR Kinase Pathways Governs the Induced by ER Stress. J. Lim, C. Yeo, K. Hur; University, Daejeon, Republic of Korea, 3Cancer Transition between Cytokinesis and Division of Life and Pharmaceutical Sciences, Research Institute, Chungnam University, Daejeon, Establishment of Interphase Polarity in Fission Ewha Womans University, Seoul, Republic of 1 1 2 Republic of Korea Yeast. S. Ray, D. McCollum, K. Kume, D. Korea Hirata2; 1Molecular Genetics and Microbiology, 674 B612 Mechanism of Apicularen A University of Massachusetts Medical School, 683 B621 Early Embryonic Lethality Acetate-induced Cell Death in HM7 Colon Worcester, MA, 2Graduate School of Advanced Caused by Targeted Disruption of the TRAF- Cancer Cells. K. Seo,1 J. Kim,1 K. Song,1 E. Yun,1 Sciences of Matter, Hiroshima University, Higashi interacting Protein (TRIP) Gene. E. Park,1 S. J. Heo,1 J. Park,1 K. Jing,1 Y. Jung,1 Y. Jung,2 J. Hiroshima, Japan Choi,1 J. Ryu,1 B. Shin,1 S. Kim,1 S. Yang,1 J. Park,1,3 G. Kweon,1,3 S. Park,1,3 W. Yoon,1 K. Kim,2 C. Park,3 Y. Choi,4 J. Choe,5 J. Rho1; Lim,1,4 B. Hwang1,3; 1Department of Biochemistry, 666 B604 Heavy Chain Phosphorylation 1Microbiology, Chungnam National University, College of Medicine, Chungnam National Regulates Myosin-II Assembly and Contractile Taejon, Republic of Korea, 2School of Medicine, University, Daejeon, Republic of Korea, 2Laboratory Ring Dynamics during Cytokinesis in Fission Chungnam National University, Taejon, Republic of of Organomedicinal Chemistry, College of Yeast. T. E. Sladewski, M. Lord; Molecular Korea, 3RCTCP, Chungnam National University, Pharmacy, Sungkyunkwan University, Seoul, Physiology & Biophysics, University of Vermont, Taejon, Republic of Korea, 4Pathology & Republic of Korea, 3Research Institute for Medical Burlington, VT Laboratory Medicine, University of Pennsylvania Science, Chungnam University, Daejeon, Republic School of Medicine, Philadelphia, PA, 5Biological of Korea, 4Cancer Research Institute, Chungnam Sciences, KAIST, Taejon, Republic of Korea University, Daejeon, Republic of Korea

75 SUNDAY The American Society for Cell Biology 47th Annual Meeting Poster Session 1 B622–B650 December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org

684 B622 Nanosecond Pulsed Electric 693 B631 ELR-negative Chemokine IP-10/ 703 B641 Fourier Imaging Correlation Fields Cause Melanoma B16 Cells Release CXCL10 Induces Dissociation of Newly-formed Spectroscopy Studies of Mitochondrial Caspase in Time Course by Extrinsic-like, Vessels Secondary to Calpain Cleavage of ␤3 Dynamics in G1 Arrested S. cerevisiae. E. N. Cytochrome C-independent Apoptosis Pathway Integrin. R. J. Bodnar,1,2 C. C. Yates,1 A. Wells1,2; Senning, A. H. Marcus; Chemistry, University of (66 Melanomas In Vivo Analysis). X. Chen,1 J. R. 1Pathology, University of Pittsburgh, Pittsburgh, PA, Oregon, Eugene, OR Swanson,1 S. J. Beebe,1 W. Ren,1 S. Zheng,2 J. F. 2Research and Development, Pittsburgh Veterans Kolb,3 K. H. Schoenbach3; 1Old Dominion Affairs Medical Center, Pittsburgh, PA 704 B642 Using Microrheology to University, Norfolk, VA, 2Department of Determine In Vivo Force-Velocity Curves for Hepatopancreatobiliary Surgery, The 1st Teaching Cooperating Groups of Motor Proteins. J. C. 1 1 1 Hospital of Medical School, Old Dominion Intracellular Movement Macosko, G. M. Holzwarth, T. Cayhuti, Y. 1 2 2 1 University, Hangzhou, Zhejiang, China, 3Old Shtridelman, D. DeWitt, B. Townsend ; Physics, Dominion University, Frank Reidy Research Center 694 B632 Search-and-Capture of Membrane Wake Forest University, Winston-Salem, NC, 2 for Bioelectrics, Norfolk, VA Organelles by Dynamic Microtubules Is Biology, Liberty University, Lynchburg, VA Required for Initiation of Dynein-dependent 705 B643 Actin-dependent Mobility of the 685 B623 Screening of Novel Organotin Transport. A. Lomakin,1,2 I. Semenova,1 E. 26S Proteasome in Schizosaccharomyces Compounds for Cytotoxic and Nadezhdina,2 A. Akhmanova,3 V. I. Rodionov1; 1 pombe. Z. Sha, R. Cabrera, M. Dickinson, E. Antimicrobacterial Effects. A. Varela-Ramirez, 1Cell Biology, University of Connecticut Health 1 2 1 Chang; The Breast Center, Baylor College of M. Costanzo, Y. Carrasco, L. Godinez, K. H. Center, Farmington, CT, 2Moscow State University, 2 1 1 Medicine, Houston, TX Pannell, R. J. Aguilera ; Biology, University of Moscow, Russian Federation, 3Erasmus Medical Texas at El Paso, El Paso, TX, 2Chemistry, Center, Rotterdam, The Netherlands 706 B644 The Phosphoinositide PI(3,4)P2 University of Texas at El Paso, El Paso, TX Regulates the Formation of Actin Tails at the 695 B633 Regulation of Class V Myosin- Phagosome Membrane During the 686 B624 Comparison of Apoptosis-related driven Transport of Organelles. A. D. Phagocytosis Mediated by the CR3 Receptor. G. Genes Pathway in Liver Regeneration. Y. Lee, J. Fagarasanu,1 Y. Jin,2 L. S. Weisman,2 R. A. Cosio, S. Grinstein; Cell Biology, Hospital for Sick Keum, C. Lee, D. Kim, Y. Hwang; Division of Rachubinski1; 1University of Alberta, Edmonton, Children, Toronto, ON, Canada Biological Science, Gachon Univ. of Medicine & AB, Canada, 2University of Michigan, Ann Arbor, MI Science, Incheon, Republic of Korea 707 B645 Rab2 Indirectly Associates with 696 B634 Dilute Suppressor Is a Negative Microtubules through Interaction with GAPDH 687 B625 Radiation Sensitizer BrdU Regulator of Melanosome Transfer. X. S. Wu, J. and aPKC. S. C. Tucker, C. R. Artalejo, E. J. Favours Apoptosis by Accelerating Induction of A. Hammer; Lab of Cell Biology, NIH, Bethesda, Tisdale; Pharmacology, Wayne State University Pro-apoptotic Bax. M. Strasberg Rieber, M. MD Rieber; Tumor Cell Biology Laboratory, CMBC, School of Medicine, Detroit, MI 697 B635 Concanavalin A Inhibits IVIC, Caracas, Venezuela 708 B646 Madmax Recruits Dynein and Melanosome Aggregation but Not Dispersion in 688 B626 Heme Oygenase-1 Expression Kinesin-3 Motors and Coordinates Exocytotic Retinal Pigment Epithelial Cells. P. J. Gannon, C. 1 and Phosphorylation of Erk1/2 Induced by Rab6 Vesicle Transport. M. A. Schlager, I. King-Smith; Department of Biology, Saint Joseph's 2 2 1 Prostaglandin A in U2OS Cells. K. Ko, J. Kim, Grigorev, A. Akhmanova, C. C. Hoogenraad ; 2 University, Philadelphia, PA 1 H. Kim, S. Lee; Department of Biochemistry, Neuroscience, Erasmus MC, Rotterdam, The 2 College of Medicine, The Catholic University of 698 B636 The Phosphatase Inhibitor, Netherlands, Cell Biology and Genetics, Erasmus Korea, Seoul, Republic of Korea Calyculin A, Stimulates Melanosome MC, Rotterdam, The Netherlands Aggregation in Fish Retinal Pigment Epithelial 709 B647 AKAP350A, CCAR1, and Caprin 689 B627 Electron Microscopic Aspects of (RPE) Cells. J. L. Oates, C. King-Smith; Nickel Influence on Rat Testis. A. Indrei,1 L. Form a Cytosolic Complex Regulating Delivery Department of Biology, Saint Joseph's University, 1 Indrei,2 M. Nechifor3; 1Anatomy, University of to RNA Stress Granules. E. Kolobova, A. Philadelphia, PA 2 2 3 4 Medicine and Pharmacy, Iasi, Romania, Efimov, I. Kaverina, A. Rishi, J. W. Schrader, A. 5 6 1 1 2Preventive Medicine, University of Medicine and 699 B637 Rab32 Regulates Melanosome Ham, M. C. Larocca, J. R. Goldenring ; Surgery Pharmacy, Iasi, Romania, 3Pharmacology, Transport in Xenopus Melanophores by Protein and Cell and Developmental Biology, Vanderbilt 2 University of Medicine and Pharmacy, Iasi, Kinase A (C␤/RII␣) Recruitment. M. Park,1 A. S. University, Nashville, TN, Cell and Developmental Romania Serpinskaya,1 N. Papalopulu,2 V. I. Gelfand1; 1Cell Biology, Vanderbilt University, Nashville, TN, and Molecular Biology, Northwestern University, 3Internal Medicine, Wayne State University and Chicago, IL, 2Faculty of Life Sciences, The John Dingell VAMC, Detroit, MI, 4Biomedical Cytokines University of Manchester, Manchester, United Research Centre, University of British Columbia, Kingdom Vancouver, BC, Canada, 5Department of 690 B628 Effects of FGF-1 and -2 on Biochemistry, Vanderbilt University, Nashville, TN, Expression of EGR-1 in Human Pulpal 700 B638 Swelling-induced Trafficking of 6Instituto de Fisiología Experimental, Universidad Fibroblasts. I. Tamura,1 B. Chaqour,2 P. S. Actin-coated Vesicles and Control of Nacional de Rosario, Rosario, Argentina Howard,3 T. Ikeo,1 E. J. Macarak3; 1Biochemistry, Hepatocyte Volume Regulation by Myosin Light 1 2 710 B648 Mitochondrial Membrane Osaka Dental University, Hirakata, Japan, Chain Kinase. E. Barfod, A. L. Moore, S. D. 2 1 Potential Does Not Vary with Transport or 2Anatomy and Cell Biology, State University of New Lidofsky ; Pharmacology, University of Vermont, 2 Location in the Axon, but Is Increased Locally York, Brooklyn, NY, 3Anatomy and Cell Biology, Burlington, VT, Medicine, University of Vermont, by NGF or Semaphorin Signaling. J. Verburg, P. University of Pennsylvania, Philadelphia, PA Burlington, VT J. Hollenbeck; Biological Sciences, Purdue 691 B629 Central Spindle Assembly and 701 B639 Coarse-Grain Modeling of University, West Lafayette, IN Cytokinetic Mechanisms Are Developmentally Diffusion in a Crowded Cellular Environment. I. 711 B649 A Drosophila Model of Friedreich Regulated during Vertebrate Embryogenesis. E. L. Novak, P. Kraikivski, B. M. Slepchenko; Cell Ataxia Shows Disrupted Mitochondrial K. Kieserman,1 M. Glotzer,2 J. B. Wallingford1; Biology, University of Connecticut Health Center, Transport and Membrane Potential but No 1Molecular, Cell and Developmental Biology, Farmington, CT Increased ROS Production. Y. Shidara, P. J. University of Texas at Austin, Austin, TX, 702 B640 Using Causal Mapping (CMAP) Hollenbeck; Biological Sciences, Purdue University, 2University of Chicago, Chicago, IL for Hypothesis Generation in Cell Biology. G. E. West Lafayette, IN 1 1 1 692 B630 Baicalein Inhibits Inflammatory Weinreb, M. T. Kapustina, K. Jacobson, T. C. 2 1 712 B650 Dynamic Property of Alpha B- Cytokine Production from Human Mast Cells via Elston ; Cell & Developmental Biology, University Crystallin in Rat Beating Cardiac Myocyte. E. Regulation of the NF-␬B Pathway. D. S. Chi,1 C. of North Carolina–Chapel Hill, Chapel Hill, NC, 2 Ohto-Fujita,1 T. Yamaguchi,2 T. Sakurai,2 Y. Fujita,2 Hsieh,1 K. Hall,1 T. Ha,2 C. Li,2 G. Krishnaswamy1; Pharmacology, University of North Y. Atomi1; 1Integrated Research System for 1Internal Medicine, East Tennessee State Carolina–Chapel Hill, Chapel Hill, NC Sustainability Science, The University of Tokyo, University, Johnson City, TN, 2Surgery, East Tokyo, Japan, 2Department of Life Sciences, The Tennessee State University, Johnson City, TN University of Tokyo, Tokyo, Japan

76 The American Society for Cell Biology 47th Annual Meeting SUNDAY December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org Poster Session 1 B651–B678

713 B651 Myosin II Acts Downstream of 720 B658 Electron Tomography and 729 B667 Expression of Pathogenic Heterotrimeric G Protein Signaling to Promote Molecular Modeling of -Tropomyosin E245D Mutation Results in Amorphous Centrosome Movement in the C. elegans Regulated Thin Filaments. C. Xu,1 H. Jung,2 A. Aggregates and Disruption of Actin Filament Zygote. M. Goulding, E. Senning, J. Canman, A. Galinska-Rakoczy,3 P. Engel,4 R. Craig,2 L. and Organization. G. M. Conover, C. C. Marcus, B. Bowerman; Institute of Molecular Tobacman,4 W. Lehman3; 1Brandeis University, Gregorio; Cell Biology and Anatomy, University of Biology, University of Oregon, Eugene, OR Waltham, MA, 2University of Massachusetts Arizona, Tucson, AZ Medical School, Worcester, MA, 3Department of 714 B652 Nuclear Envelope Components Physiology & Biophysics, Boston University School 730 B668 Interactions of Nebulette with and Coordination of Microtubule Motors during of Medicine, Boston, MA, 4University of Illinois, Tropomyosin. J. R. Bonzo, M. Esham, W. B. Nuclear Positioning. H. Petersen, M. Meyerzon, Chicago, Chicago, IL Holmes, C. L. Moncman; Molecular & Cell D. A. Starr; Molecular and Cellular Biology, Biochemistry, University of Kentucky, Lexington, KY University of California–Davis, Davis, CA 721 B659 Impact of Proteolytic Activity of Muscle-specific Calpain, p94/calpain3, on Its 731 B669 The Cardiac Myosin Activator 715 B653 RNP Stress Granule Dynamics Localization in . K. Ojima,1,2 Y. Ono,1 CK-1827452-induced Myocyte Contractility Is ␤ Depends on Microtubules and Microtubule N. Doi,1,2 S. Labeit,3 H. Sorimachi1,2; 1Department Unchanged in the Presence of -Blockade. R. L. 1 1 1 1 2 Motors. P. A. Ivanov, A. Y. Lomakin, E. S. of Enzymatic Regulation for Cell Functions, Tokyo Anderson, M. Pokrovskii, K. Suekawa, H. M. 2 1 2 1 1 Nadezhdina ; M.V. Lomonosov Moscow State Metropolitan Institute of Medical Science, Tokyo, Rodriguez, K. A. Elias ; Molecular and Cell 2 University, Moscow, Russian Federation, Institute Japan, 2CREST, Japan Science and Technology Biology, Cytokinetics, Inc., South San Francisco, 2 of Protein Research of Russian Academy of Agency (JST), Kawaguchi, Japan, 3Institut für CA, Biochemistry, Cytokinetics, Inc., South San Science, Moscow, Russian Federation Anästhesiologie und Operative Intensivmedizin, Francisco, CA 716 B654 Syne/SUN Protein, Nuclear Universitätsklinikum Mannheim, Mannheim, 732 B670 Role of Nonmuscle Myosin IIB Positioning, and Chromosome Dynamics during Germany and N-RAP in Regulation of Cell Spreading and 1 1 Animal Development. R. Xu, X. Zhang, X. 722 B660 Functional Study of Fast Skeletal Assembly in Primary Mouse 1 1 2 3 4 Ding, J. Yu, Y. Zhuang, T. Xu, M. Han ; RLC during Myofibrillogenesis: Is Cardiomyocytes. S. Lu, R. Horowits; NIAMS, 1 Institute of Developmental Biology and Molecular Phosphorylation Necessary? J. D. Eskew, M. B. National Institutes of Health, Bethesda, MD Medicine, Shanghai, China, 2Department of Ferrari; Molecular Biology, University of Missouri, 733 B671 Kelch-related Protein Krp1 Is Immunology, Duke University Medical Center, Kansas City, MO Durham, NC, 3Howard Hughes Medical Institute Required for Mature Myofibril Accumulation in and Department of Genetics, Yale University 723 B661 Functional and Phylogenetic Cultured Mouse Cardiomyocytes. C. C. School of Medicine, New Haven, CT, 4Howard Analysis of Flightin Phosphorylation Reveal Greenberg, P. S. Connelly, M. P. Daniels, R. Hughes Medical Institute and Department of Lineage-specific Differences in Phosphorylation Horowits; National Institutes of Health, Bethesda, Molecular, Cellular and Developmental Biology, Site Selection. A. G. Montalvo, D. Lemas, P. MD University of Colorado, Boulder, Boulder, CO Lekkas, B. A. Ballif, J. O. Vigoreaux; Biology, 734 B672 Comparison of Titin’s Elastic N2B University of Vermont, Burlington, VT 717 B655 Bicaudal D2 Is a Cell-Cycle and PEVK Domains in Isolated Cardiomyocytes 1 2 2 Regulated Linker between Nuclear Pore 724 B662 Dynamics of Z-band Proteins in and In Vivo. M. H. Radke, J. Peng, L. Nelson, 2,3 1,2 1 Complex and Microtubule Motors. D. Splinter,1 Skeletal Muscle Cells: Zebrafish Myocytes in H. L. Granzier, M. Gotthardt ; Max-Delbrueck- 2 M. Tanenbaum,2 I. Grigoriev,1 A. Flotho,3 D. Living Animals Versus Avian Cells in Tissue Center, Berlin, Germany, Washington State 3 Engelsma,4 M. Fornerod,4 F. Melchior,3 R. Culture. J. W. Sanger,1 J. Wang,1 B. Holloway,2 J. University, Pullman, WA, University of Arizona, Medema,2 C. Hoogenraad,5 A. Akhmanova1; 1Cell M. Sanger1; 1Cell and Developmental Biology, Tucson, AZ Biology, Erasmus Medical Center, Rotterdam, The SUNY Upstate Medical University, Syracuse, NY, 735 B673 Regulation of Actin Filament Netherlands, 2Medical Oncology, University Medical 2Cell and Developmental Biology, University of 3 Pointed-End Dynamics in Cultured Cardiac Center, Utrecht, The Netherlands, Institute of Pennsylvania School of Medicine, Philadelphia, PA Myocytes. K. Liang, R. S. Littlefield; Center for Biochemistry and Molecular Cell Biology, Georg- Cell Dynamics, Friday Harbor Labs, University of 4Tumor 725 B663 The Role of and Its August-University, Göttingen, Germany, Washington, Friday Harbor, WA Biology, Netherlands Cancer Institute, Amsterdam, Importance in Sarcomeric Assembly. T. Sadikot, The Netherlands, 5Neuroscience, Erasmus Medical M. Ferrari; School of Biological Sciences, 736 B674 Regulation of CaM Kinase II by a Center, Rotterdam, The Netherlands University of Missouri–Kansas City, Kansas City, Small CTD Phosphatase. S. S. Gangopadhyay,1 MO C. Gallant,1 E. J. Sundberg,2 W. S. Lane,3 K. G. 718 B656 Different Isoforms of the Motor 1 1 726 B664 Molecular Insights into the Morgan ; Health Sciences, Boston University, Regulator Klar Affect Distinct Transport 2 Mechanical Properties of Titin I-Band Domains. Boston, MA, Boston Biomedical Research Processes during Drosophila Oogenesis. S. 3 1 1 2 Institute, Watertown, MA, Microchemistry & Cotton,1 A. Norvell,2 M. Welte3,1; 1Biology, Brandeis T. Garcia, W. Braun, A. F. Oberhauser ; 1 Proteomics Analysis Facility, Harvard University, 2Biology, The College of Biochemistry and Molecular Biology, University of University, Waltham, MA, Cambridge, MA New Jersey, Ewing, NJ, 3Biology, University of Texas Medical Branch, Galveston, TX, 2Neuroscience and Cell Biology, University of Rochester, Rochester, NY 737 B675 Binding Partners for UNC-89 Texas Medical Branch, Galveston, TX (Obscurin) in C. elegans: How to Catch Moby Muscle: Biochemistry and Cell Biology 727 B665 Titin’s M-band in Striated Muscle Dick. G. Xiong, H. Qadota, L. A. McGaha, G. M. Atrophy and Hypertrophy. K. Raddatz,1 J. Peng,2 Benian; Pathology, Emory University, Atlanta, GA H. Granzier,2,3 M. Gotthardt1,2; 1Max-Delbrueck- 719 B657 The Contribution of Myosin 738 B676 Search for Novel UNC-97/PINCH Center, Berlin, Germany, 2Washington State Binding Proteins to the Biomechanical Interactors Which Function in the Muscle of C. University, Pullman, WA, 3University of Arizona, Properties of Thick Filaments: A Comparison of elegans. H. Qadota,1 K. R. Norman,2 D. G. Tucson, AZ Normal and Mutant Thick Filaments from Flies Moerman,2 G. M. Benian1; 1Pathology, Emory 2 and Mice Using Atomic Force Microscopy. L. 728 B666 Tropomodulin1 Is Required for University, Atlanta, GA, Zoology, University of Nyland, J. Contompasis, B. M. Palmer, D. Thin Filament Length Specification in British Columbia, Vancouver, BC, Canada Maughan, J. Vigoreaux; University of Vermont, 1 R. Embryonic Skeletal Muscle. C. R. McKeown, 739 B677 The Role of UNC-95 in Burlington, VT B. Nowak,1 R. Littlefield,2 V. M. Fowler1; Caenorhabditis elegans Muscle Adhesion 1Department of Cell Biology, The Scripps Research Complexes. A. Simionescu, H. Qadota, G. M. Institute, La Jolla, CA, 2Center for Cell Dynamics, Benian; Pathology, Emory University, Atlanta, GA Friday Harbor Labs, University of Washington, Friday Harbor, WA 740 B678 Molecular Genetic Analysis of unc-100, an Important Gene for Normal Myofibril Organization in C. elegans. T. O. Stevenson, G. M. Benian; Pathology, Emory University, Atlanta, GA

77 SUNDAY The American Society for Cell Biology 47th Annual Meeting Poster Session 1 B679–B709 December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org

741 B679 Dipyridamole Inhibits Intracellular 751 B689 XMAP215 Is a Processive 761 B699 The Role of Casein Kinase 2 Calcium Transients in Isolated Rat Arteriole Microtubule Polymerase That Catalyzes Both Phosphorylated MAP1B in the Developing Smooth Muscle Cells. T. Saino, M. Matsuura, Y. Growth and Shrinkage. G. J. Brouhard,1 J. Stear,1 Central Nervous System. S. Lin, M. Kraus, P. Satoh; Histology, Iwate Medical University, Morioka, T. Noetzel,1 J. Al-Bassam,2 K. Kinoshita,3 S. Gordon-Weeks; MRC Centre for Developmental Japan Harrison,2 J. Howard,1 A. Hyman1; 1Max Planck Neurobiology, King's College London, London, Institute of Molecular Cell Biology and Genetics, United Kingdom 2+ 742 B680 Ca Imaging of Vascular Smooth Dresden, Germany, 2Harvard Medical School, Muscles Indicates That PARs Play a Role in Boston, MA, 3Kyoto University, Kyoto, Japan 762 B700 Loss of Endogenous Tissue Circulation in Brain. Y. Satoh,1 K. Masu,1 Oncoprotein18/Stathmin in Mouse Embryo T. Saino,1 M. Toshinari2; 1Histology (Anatomy2), 752 B690 Mechanisms of Tau Distribution Fibroblasts Induces Changes in Tubulin Isoform Iwate Medical University, Morioka, Japan, in Neurons. S. Konzack, E. Thies, A. Marx, E. Expression with Minimal Changes to 2Neurosurgery, Iwate Medical University, Morioka, Mandelkow, E. Mandelkow; Structural Molecular Microtubule Dynamics. D. N. Ringhoff,1 L. Japan Biology, Max-Planck-Institute, Hamburg, Germany Cassimeris2; 1Chemistry, Lehigh University, Bethlehem, PA, 2Biological Sciences, Lehigh 753 B691 Spatiotemporal CLASP University, Bethlehem, PA Microtubule-associated Proteins Regulation during Epithelial Sheet Migration. P. Kumar, K. Lyle, S. Gierke, T. Wittmann; Cell and 763 B701 Phospholipase C Activation and 743 B681 Role of EB1 in Xenopus. I. Kronja, Tissue Biology, University of California, San Inhibition Modifies Arrestin Translocation to A. Kruljac-Letunic, P. Bieling, E. Karsenti; Cell Francisco, San Francisco, CA Rod Outer Segments. W. Orisme, W. C. Smith; Biology and Biophysics, EMBL, Heidelberg, Ophthalmology, University of Florida, Gainesville, 754 B692 Stabilization of Overlapping Germany FL Microtubules by Fission Yeast CLASP. S. V. 744 B682 EB1 Is Required for Spindle Bratman, F. Chang; Microbiology, Columbia 764 B702 Identification of Molecules Symmetry in Mammalian Mitosis. A. Brüning- University, New York, NY Associating with the SAMP Domain of APC Richardson, K. J. Langford, T. Lee, J. M. Askham, Tumor Suppressor. C. Matsui,1 S. Kaieda,2 T. 755 B693 A Molecular Mechanics Model of 2 1 1 E. E. Morrison; Leeds Institute of Molecular Ikegami, Y. Mimori-Kiyosue ; Cytoskeleton & Cell Dam1-Microtubule Interactions Suggests Medicine, Leeds University, Leeds, United Kingdom Motility Research Group, KAN Research Institute, Directed Diffusion, and the Force and Binding Kobe, Japan, 2Laboratory of Structural Proteomics, 745 B683 Interaction between Microtubules Characteristics of a Novel Minus-End Directed Institute for Protein Research, Osaka University, 1 2 and Truncated Forms of Mal3p Studied by Motor. K. Skotheim Hillis, J. B. Alberts, A. D. Suita, Japan Electron Microscopy. L. Sandblad,1 D. Brunner,1 Franck,3 A. F. Powers1; 1University of Washington, A. Hoenger2; 1Cell Biology and Biophysics Unit, Seattle, WA, 2Biology, University of Washington, 765 B703 ELP-1 Microtubule-binding European Molecular Biology Laboratory, Seattle, WA, 3Physiology, University of Washington, Protein Protects against a Small and Pale Body. Heidelberg, Germany, 2Department of Molecular Seattle, WA J. Hueston, M. Buechner, E. Lundquist, G. Cell and Developmental Biology, University of Purinton, K. Suprenant; Molecular Biosciences, 756 B694 Microtubule-driven Colorado at Boulder, Boulder, CO University of Kansas, Lawrence, KS Multimerization Recruits Ase1 Towards 746 B684 Coordination of Microtubule Overlapping Microtubules. L. C. Kapitein,1 M. E. 766 B704 The Role of the Cytoskeleton in Regulator Expression. S. Domnitz, L. Wordeman; Janson,1 C. F. Schmidt,2 E. J. G. Peterman1; Peroxisomal Matrix Protein Translation and University of Washington, Seattle, WA 1Physics and Astronomy, Vrije Universiteit, Import in Plant Cells. L. A. Vickerman, M. C. Amsterdam, The Netherlands, 2Physikalisches Freeman, S. D. X. Chuong, D. G. Muench; 747 B685 Mechanisms of End-tracking by Institut, Georg-August-Universität, Göttingen, Biological Sciences, University of Calgary, Calgary, Microtubule-associated Proteins. L. M. Goins,1 J. Germany AB, Canada M. Dawicki McKenna,1 X. Chen,1 A. E. Cohen,1 A. Franck,1 C. Fu,1 K. Kasza,1 C. Vizcarra,1 Z. 757 B695 Functional Analysis of the 767 B705 Investigating Microtubule Wunderlich,1 J. Husson,2 C. Tischer,2 M. Microtubule Binding Domain of CLIP-170. K. K. Associated Proteins Using Bioinformatics. K. H. Dogterom2; 1MBL, Woods Hole, MA, 2AMOLF, Gupta,1 E. S. Folker,2 Z. Zhu,1 S. B. Skube,1 E. Fisher,1,2 R. Saeed,3,2 C. M. Deane,3 J. G. Amsterdam, The Netherlands Lastochkin,1 H. V. Goodson1; 1Chemistry and Wakefield1,2; 1Department of Zoology, University of Biochemistry, University of Notre Dame, Notre Oxford, Oxford, United Kingdom, 2Life Sciences 748 B686 Microtubule Associated Protein Dame, IN, 2Department of Anatomy and Cell Interface Doctoral Training Centre, University of Complexes with Roles in Cell Cycle Regulation Biology, Columbia University, New York, NY Oxford, Oxford, United Kingdom, 3Department of and Mitosis. J. R. Hughes,1 A. M. Sousa,2 K. Statistics, University of Oxford, Oxford, United Fisher,1 A. Garcia-Alonso,3 P. R. Antrobus,3 A. 758 B696 Two Types of Post-translational Kingdom Wainman,1 N. Zitzmann,3 C. Deane,4 H. Ohkura,2 Modifications May Modify Bik1p, the CLIP-170 J. G. Wakefield1; 1Department of Zoology, Orthologue in Yeast. S. D`Silva,1 N. Meednu,1 H. University of Oxford, Oxford, United Kingdom, Hoops,2 R. K. Miller1; 1Department of Biology, Neurotransmitters, Peptides, and Receptors 2Wellcome Trust Centre for Cell Biology, University University of Rochester, Rochester, NY, of Edinburgh, Edinburgh, United Kingdom, 2Department of Biology, State University of New 768 B707 Serpinin, a Novel Chromogranin 3Department of Biochemistry, University of Oxford, York, Geneseo, NY A (CgA)-derived Peptide Induces Granule Oxford, United Kingdom, 4Department of Statistics, Biogenesis in Endocrine Cells. H. Koshimizu, T. 759 B697 Brain Cytosolic Fraction Contains University of Oxford, Oxford, United Kingdom Kim, Y. Loh; NICHD, NIH, Bethesda, MD ␥TuRC That Nucleates Microtubules In Vitro but 749 B687 NuSAP Is Essential during May Have Some Other Function. N. E. Thomas, 769 B708 Involvement of the Peripheral Embryogenesis by Regulating Mitotic Spindle S. Sengupta; Molecular Medicine and Cancer Nervous System on Hormonal Release from the Organization. A. Vanden Bosch,1 S. Torrekens,1 T. Research, Rajiv Gandhi Centre for Biotechnology, Testis. J. Cavicchia,1 Z. Sosa,2 N. Palmada,1 M. Raemaekers,2 M. Van Camp,1 G. Carmeliet1; Trivandrum, India Fóscolo,1 M. H. Burgos1; 1Cuyo Medical School, 1Laboratory of Experimental Medicine & Institute of Histology and Embryology (IHEM), 760 B698 MAP1B Interaction with TTL Endocrinology, Katholieke Universiteit Leuven, Mendoza, Argentina, 2National University of San Modulates Microtubule Tyrosination. E. Leuven, Belgium, 2Membrane Trafficking Luis, LABIR, San Luis, Argentina Contreras-Vallejos,1 E. Utreras,1 E. Jimenez- Laboratory, Center for Human Genetics/VIB04, Mateos,2 S. Rojas,1 E. Tortosa,2 R. B. Maccioni,3 J. Katholieke Universiteit Leuven, Leuven, Belgium 770 B709 Gene Organization of the Lobster Avila,2 C. Gonzalez-Billault1; 1Biology, Faculty of (Homarus americanus) Gonad-inhibiting 750 B688 Fission Yeast XMAP215/TOG Sciences, Institute for Cell Dynamics and Hormone (GIH), and Its Functional Analysis in Homologue Alp14 Revisited in Interphase. L. J. Biotechnology, Universidad de Chile, Chile, 2Centro Relation to Vitellogenesis by RNA Interference. Murrells,1 J. Solon,1 H. D. Roque,1 K. E. Busch,2 de Biologia Molecular Severo Ochoa, Universidad K. Y. K. So, S. M. Chan; School of Biological C. Antony,1 D. Brunner1; 1Cell Biology, EMBL, Autonoma de Madrid, Spain, 3Faculty of Sciences, Sciences, The University of Hong Kong, Hong Heidelberg, Germany, 2Cell Biology, MRC Universidad de Chile, Chile Kong SAR, China Laboratory of Molecular Biology, Cambridge, United Kingdom

78 The American Society for Cell Biology 47th Annual Meeting SUNDAY December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org Poster Session 1 B710–B731

771 B710 NMDA Receptors Interact with 780 B719 Brain Glucose Sensing 788 B727 Retinoic Acid induces Functional Flotillin-1, a -associated Protein. C. Mechanism: Distribution and Function of c-Ret Tyrosine Kinase in Human Swanwick, M. E. Shapiro, Z. Yi, K. Chang, R. J. Monocarboxylate Transporter 1 in Neuroblastoma. S. Yamada, S. Fujita, M. Miyake, Wenthold; NIDCD, National Institutes of Health, Hypothalamus. C. Cortes, F. Nualart, M. Garcia; J. Miyake; AIST, Kohtoh-ku, Japan Bethesda, MD Cellular Biology, University of Concepcion, Concepcion, Chile 789 B728 The Phenotype of Non- 772 B711 Potential Role of the /745 myelinating Oligodendrocytes. S. Szuchet,1 J. A. Phosphorylation Site of Ras-GRF1 in 781 B720 Subunit-specific Contribution of Nielsen,2 G. Lovas,3 D. Maric,4 L. D. Hudson2; Regulation of Interaction with NMDA-R2B and the ␤1 Strand of the AChR ␦ Subunit to 1Department of Neurology, The University of Activation of Rac. K. M. Sane,1 H. Yang,2 R. R. Channel Gating in A Congenital Myasthenic Chicago, Chicago, IL, 2Section of Developmental Mattingly1; 1Pharmacology, Wayne State University, Syndrome (CMS). X. Shen,1 K. Ohno,1 J. M. Genetics, National Institute of Neurological Detroit, MI, 2University of Michigan, Ann Arbor, MI Brengman,1 T. Fukuda,1 S. M. Sine,2 A. G. Engel1; Disorders and Stroke, National Institutes of Health, 1Neurology, Mayo Clinic, Rochester, MN, Bethesda, MD, 3Department of Neurology, 773 B712 Prevalence of Monomeric 2Physiology, Mayo Clinic, Rochester, MN Semmelweis University, Budapest, Hungary, GABA(B) Receptor Subunits in Dendrites and 4Laboratory of Neurophysiology, National Institute 1 Axons of Hippocampal Neurons. O. A. Ramirez, 782 B721 A Functional Role for Epidermal of Neurological Disorders and Stroke, National 1 1 2 3 R. L. Vidal, J. A. Tello, S. Kindler, S. Hartel, A. Growth Factor Receptor Signaling in Institutes of Health, Bethesda, MD Couve1; 1Physiology and Biophysics, Universidad Myelination and Remyelination. A. Aguirre,1 J. de Chile, Santiago, Chile, 2Universitaetsklinikum, Dupree,2 J. Mangin,1 G. Vittorio1; 1Center for 790 B729 Promoter Stimulation as a Hamburg, Germany, 3Anatomy and Development, Neurosciences, CNMC, CRI, Washington, DC, Strategy for the Fragile X Syndrome. Y. Zhang, Universidad de Chile, Santiago, Chile 2Department of Anatomy and Neurobiology, Virginia A. M. Tartakoff; Pathology, Case Western Reserve Commonwealth University Medical Campus, University, Cleveland, OH 774 B713 Specific PP2A Heterotrimers Richmond, VA Associate with the TrkA Receptor Tyrosine 791 B730 Microsporidian Spore Invasion Kinase to Enhance Nerve Growth Factor- 783 B722 Role of Plasma Membrane Tubes: Spraguea Spore Activation Triggered by mediated Signaling and Neuronal Calcium ATPases in Mouse Olfactory Neurons. Acetylcholine at Target Sites. E. Weidner, K. Differentiation. M. J. Van Kanegan, S. Strack; S. Ponissery Saidu, S. D. Weeraratne, M. S. Svoboda; Biological Sciences, Louisiana State Pharmacology, University of Iowa, Iowa City, IA Valentine, R. J. Delay, J. L. Van Houten; University, Baton Rouge, LA Department of Biology, University of Vermont, ␤ 775 B714 CRMP-2 and GSK-3 Regulate Burlington, VT 792 B731 Mode of Action of a Novel Anterograde TrkB Transport through Slp1 and Antimicrobial Peptide, Urechistachykinins Rab27 for Neuronal Polarization. N. Arimura, S. 784 B723 Expression of A20 Protein in Derived from the Echiuroid Worm, Urechis Nakamuta, A. Shimada, Y. Funahashi, K. Kaibuchi; Brain of Rats Sprague-Dawley Exposed to unicinctus. W. Sung, S. Park, D. Lee; Department Nagoya University, Nagoya, Japan Septic Shock. E. Meza-Lamas, J. J. Bollain y of Microbiology, College of Natural Sciences, Goytia-De la Rosa, M. G. Pacheco-Tovar, E. Kyungpook National University, Daegu, Republic of 776 B715 Increase in Cell Surface Avalos-Diaz, R. Herrera-Esparza, E. E. Lopez- Korea Expression of Histamine H3 Receptor by a Robles; Immunology/Molecular Biology Chloride Intracellular Channel Protein. K. Laboratories, Experimental Biology Center, 1,2 1,3 4 1 Maeda, M. Haraguchi, A. Kuramasu, T. Sato, Universidad Autonoma de Zacatecas, Guadalupe, 4 3,2 1,2 K. Yanai, K. Fukunaga, T. Yanagisawa, J. Zacatecas, Mexico Sukegawa1; 1Department of Molecular Pharmacology, Tohoku University Graduate School 785 B724 Evidence for an Alternatively of Medicine, Sendai, Japan, 2Tohoku University Spliced Serine Racemase mRNA Isoform: a1/2b. 21st Century COE Program "CRESCENDO", D. Wade,1 S. W. Barger2; 1Science, Central Baptist Sendai, Japan, 3Department of Pharmacology, College, Conway, AR, 2Geriatrics, Neurobiology & Graduate School of Pharmaceutical Sciences, Developmental Science, University of Arkansas for Tohoku University, Sendai, Japan, 4Department of Medical Sciences, Little Rock, AR Pharmacology, Tohoku University Graduate School of Medicine, Sendai, Japan 786 B725 VEGF Is a Chemo-attractant for Cerebellar Granule Cell Neuron during Radial 777 B716 Yif1B, a New Protein Interacting Migration. C. Meissirel,1 C. Ruiz de Almodovar,2 P. with the Serotonin 5-HT1A Receptor, Specifies Salin,3 N. Chounlamountri,1 E. Storkebaum,2 U. Its Dendritic Localisation in Rat Neurons. J. Eriksson,4 J. Haigh,5 J. Honnorat,6 L. Moons,7 P. Masson,1 D. Carrel,1 S. Al Awabdh,1 C. Borg Carmeliet,2 N. G. Thomasset8; 1Faculty of Capra,2 J. Lainé,3 M. Hamon,1 M. B. Emerit,1 M. Medicine, INSERM 842, Lyon, France, 2University Darmon1,4; 1Université Pierre et Marie Curie, of Leuven, The Center for Transgene Technology INSERM U677, Paris, France, 2Hybrigenics, Paris, and Gene Therapy, Flanders Interuniversitary France, 3Faculté de Médecine Pierre et Marie Institute for Biotechnology (VIB), Leuven, Belgium, Curie, Département de Physiology, Paris, France, 3Faculty of Medicine, Centre National de la 4Faculté de Médecine Pitié Salpêtrière, Université Recherche Scientifique UMR5167, Lyon, France, Pierre et Marie Curie, Paris, France 4Stockholm Branch, Ludwig Institute for Cancer Research, Stockholm, Sweden, 5Department for 778 B717 Modulation of Neuronal Molecular Biological Research, VIB, The Center for Excitability and Synaptic Transmission in the Transgene Technology and Gene Therapy, Main Olfactory Bulb (MOB) through G-Protein University of Ghent, Ghent, Belgium, 6Faculty of Coupled Receptors. T. Heinbockel, Z. Wang; Medicine, INSERM 842, Hopital Hospice Civil de Anatomy, Howard University College of Medicine, Lyon, Lyon, France, 7University of Leuven, The Washington, DC Center for Transgene Technology and Gene Therapy, Flanders Interuniversitary Institute for 779 B718 Ultrastructural and Functional Biotechnology, Leuven, Belgium, 8University Lyon1, Characterization of Sensory Receptor Cells in IFR19, INSERM 842, Lyon, France an Insect Taste Organ. V. D. C. Shields, A. Siebert, I. Gordon; Biological Sciences, Towson 787 B726 Altered High Affinity Choline University, Towson, MD Uptake in Cholinergic Neurons from Par-4 Transgenic Mice. Q. Guo, J. Xie; Department of Physiology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK

79 SUNDAY The American Society for Cell Biology 47th Annual Meeting December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org

NOTES

80 The American Society for Cell Biology

Monday December 3, 2007

47th Annual Meeting Washington, DC MONDAY The American Society for Cell Biology 47th Annual Meeting

December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

7:00 am –10:30 pm Exhibitor Showcases

7:30 am –5:00 pm Registration Open (East Registration)

7:30 am –9:00 pm Posters on Display (Halls A/B)

7:30 am –9:00 pm Career Center (Hall B)

8:00 am –9:30 am Symposium III (Ballrooms A/B/C)—Heinz Herrmann Symposium Cell Biology of Metazoan Development

9:00 am –4:00 pm Exhibits Open (Halls A/B)

9:00 am –5:00 pm Education Resources/MAC Booth Open (Grand Lobby)

9:30 am–10:30 am Congress 101 (Room 158 A/B)

9:30 am–10:30 am Morning Refreshment Break (Halls A/B)

9:45 am–10:15 am Education Initiative Forum (Room 140A) Integrating Quantitative Modeling into Cell Biology—Raquell M. Holmes, Boston University and University of Connecticut Health Center, and Leslie M. Loew, University of Connecticut Health Center

10:00 am–12:00 Noon Subcommittee on Postdoctoral Training (SCOPT) Meeting (Room 142) All postdocs and early career scientists are invited to attend from 10:00 am–11:00 am.

10:30 am–12:00 Noon Symposium IV (Ballrooms A/B/C) Unconventional Organelles

(Ticket required) 12:00 Noon–1:30 pm Career Discussion Lunch Offered by the Women in Cell Biology Committee (West Registration) (Doors open at 11:30 am.)

12:00 Noon–3:00 pm Poster Presentations (Halls A/B) Odd Boards: 12:00 Noon–1:30 pm; Even Boards: 1:30 pm–3:00 pm

2:00 pm–3:00 pm Congressional Liaison Committee Seminar: Mock Congressional Offi ce Meetings (Room 156)

2:00 pm–3:00 pm NSF Grant Opportunities in Biological Sciences and Educational Activities (Room 147)

2:30 pm–3:30 pm Afternoon Refreshment Break (Halls A/B)

3:40 pm–5:45 pm Minisymposium 9 (Room 146) Minisymposium 13 (Ballroom B) Apoptosis and Organelles Molecular Motors: Alone and in Groups Minisymposium 10 (Ballroom C) Minisymposium 14 (Room 207) Cell Migration/Motility Nuclear Import and Export Minisymposium 11 (Room 145) Minisymposium 15 (Room 147) Mechanisms of Epigenetic Regulation Prokaryotic Cell Biology Daily Schedule—Monday, December 3 Daily Schedule—Monday, Minisymposium 12 (Ballroom A) Minisymposium 16 (Room 202) Mechanisms of Membrane Traffi cking X-ylation and Cell Signaling

5:30 pm–6:30 pm Practice of Science (Room 143 A/B)—Challenges and Opportunities for NIH Peer Review

6:00 pm–7:30 pm Tutorials A. High Affi nity Antibody Development, Conjugation & Applications E. Applications of RNAi in the Study of Cell Biology (Room 204B) of Reagents for Total Cytotoxicity, Cell Proliferation, Cell Perme- F. Using NCBI’s Basic Local Alignment Search Tool: New Features and ant Apoptosis and Setting Up Multiplexed Immunological and Enhanced Interface (Room 204A) Molecular (Genotyping) Assays (Room 209A) G. Understanding and Performing DNA and siRNA Transfection with B. Studying Living Cells with Atomic Force Microscopy (Room 209B) Nonviral Vectors (Room 204C) C. Protein Dynamics Studied with Self-Labeling Protein Tags H. Optical and Atomic Force Microscopy: An Integrated Approach to (Room 203) Life Science (Room 209C) D. Development and Application of Novel Photo-Switching/Photo- activatable and Sensory Proteins (Room 208)

6:30 pm–8:00 pm Women in Cell Biology Evening Program and Awards Presentation (Room 147) But I Have a Family!

82 The American Society for Cell Biology 47th Annual Meeting MONDAY

December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

ASCB Annual Meeting Highlights—Monday, December 3

Q Symposium III 8:00 am –9:30 am Ballrooms A/B/C Cell Biology of Metazoan Development—Heinz Herrmann Symposium Kathryn Anderson, Memorial Sloan-Kettering Cancer Center, Marie-Anne Felix, Jacques Monod Institute, CNRS, Richard Harland, University of California, Berkeley, R. Dyche Mullins, (Chair), University of California, San Francisco

8:00 am Introduction 8:10 am 793 The Cell Biology of Embryonic Patterning and Morphogenesis in the Mouse Embryo. K. V. Anderson, J. Bloomekatz, J. D. Lee, I. Migeotte, P. J. R. Ocbina; Developmental Biology, Memorial Sloan-Kettering Cancer Center, New York, NY 8:35 am 794 BMP Antagonists in Vertebrate Development. R. Harland; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 9:00 am 795 Robustness and Evolution of Caenorhabditis Vulva Development. C. Braendle, J. Milloz, M. A. Felix; Jacques Monod Institute, CNRS-University of Paris 6/7, Paris, France

Q Congress 101, A Case Study on How to Be an Advocate for Science 9:30 am–10:30 am Room 158 Refreshments Served

Paul Berg Sean Morrison Thomas Pollard Stanford University University of Michigan Yale University School of Medicine Medical School/HHMI

Join Nobel Laureate Paul Berg, Sean Morrison, ASCB Public Policy Chair Thomas Pollard, and others for an informative presentation and discussion about the important role the science community can play in scientifi c advocacy. Researchers’ involvement in stem cell research advocacy will be used as a case study.

Most of the time will be devoted to audience discussion.

Q Morning Refreshment Break 9:30 am–10:30 am Halls A/B Supported by Nature Publishing Group

83 MONDAY The American Society for Cell Biology 47th Annual Meeting

December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

Q Education Initiative Forum 9:45 am–10:15 am Room 140A Refreshments Served Sponsored by the Education Committee Integrating Quantitative Modeling into Cell Biology

Raquell M. Holmes Leslie M. Loew Boston University and University of Connecticut Health Center University of Connecticut Health Center

Learn about the use of simulation tools, Stella and Virtual Cell, to teach quantitative cell biology and modeling. Through course projects, labs, and exercises, students learn to extract quantitative values, construct models, and develop an understanding of biological concepts and experimental methods. The distinct strategies and objectives used in undergraduate and graduate courses, including assessment of student learning, will also be discussed.

9:45 am 796 Teaching Modeling and Quantitative Cell Biology. R. M. Holmes,1,2 A. E. Cowan,2 I. I. Moraru,2 J. Schaff,2 B. M. Slepchenko,2L. M. Loew2; 1Center for Computational Science, Boston University, Boston, MA, 2Center for Cell Analysis and Modeling, University of Connecticut Health Center, Farmington, CT

Q Subcommittee on Postdoctoral Training (SCOPT) Meeting 10:00 am–12:00 Noon Room 142

All postdocs and early career scientists are invited to attend from 10:00 am–11:00 am.

Q Symposium IV 10:30 am–12:00 Noon Ballrooms A/B/C Unconventional Organelles Martina Brueckner, Yale University School of Medicine, Stephen Gould, Johns Hopkins University, Yoshinori Ohsumi, National Institute for Basic Biology, Joel Rosenbaum (Chair), Yale University

10:30 am Introduction 10:40 am 797 Ciliary Signalling in Vertebrate Left-Right Development. M. Brueckner,1 S. Makova,1 J. McGrath2; 1Department of Pediatrics, Yale University, New Haven, CT, 2Departments of Comparative Medicine, Genetics and Pediatrics, Yale University, New Haven, CT 11:05 am 798 Higher-Order Oligomerization Targets Plasma Membrane Proteins, Including HIV Gag, to Exosomes. Y. Fang, N. Wu, S. J. Gould; Department of Biological Chemistry, Johns Hopkins University, Baltimore, MD 11:30 am 799 Molecular Dissection of Membrane Dynamics during Autophagy. Y. Ohsumi; Department of Cell Biology, National Institute for Basic Biology, Okazaki, Japan

84 The American Society for Cell Biology 47th Annual Meeting MONDAY

December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

Q Career Discussion Lunch 12:00 Noon–1:30 pm (Doors open at 11:30 am.) West Registration (Ticket Required) Sponsored by the Women in Cell Biology Committee A limited number of tickets will be available for $20 ($15 students) at the Event Ticket Counter. Participants will: Q Meet informally for roundtable discussions on issues of importance to cell biologists at various stages of their careers Q Have moderated conversations by individuals experienced in various professional areas or with particular issues Q Exchange practical information on career choices Q Discuss strategies for effectively developing a career Q Make contacts with others who share career interests and concerns Q Enjoy a collegial lunch

Table topics are: Career Options: Career Issues: A. Biotech and Pharmaceutical L1. Obtaining an Appropriate Postdoc Position B. Management Consulting and Venture Capital L2. Careers in the Era of Extended Postdocs C. Patent Law/Intellectual Property M. Job Application Strategies for Academic Positions D. Scientifi c Writing N. Developing Your Administrative Techniques/Management E. Scientifi c Editing Skills F1. Careers in Computational Biology O. Collaborations and Authorship F2. Information Science-Related Jobs P. Family and Career Issues G. Working with Congress and Federal Government Q. Mentoring and Being Mentored H. Working in Scientifi c Foundations and Funding Agencies R. Funding Opportunities for Research at Primarily I. Research in Government Laboratories Undergraduate Institutions J. Teaching and Research in Primarily Undergraduate S. Mid-Career Transitions Institutions T. Setting Up Your First Laboratory K. Developing Your Career U. Ethics and the Politics of Science V. Issues for Women in Science W. Gay and Lesbian Issues in Science X. For Undergraduates: What Comes Next? Y. Issues for International Scientists in the U.S. Z. Advocacy for Science Education

FOR CAREER DISCUSSION LUNCH ATTENDEES SCHEDULED TO PRESENT A POSTER ON MONDAY, DEC. 3: We suggest you post a notice on your poster saying that you will be present from 1:30 to 3:00 pm.

Q Congressional Liaison Committee Seminar 2:00 pm–3:00 pm Room 156 Refreshments Served Mock Congressional Offi ce Meetings Meet with staff members from congressional offi ces to learn the most effective way to carry the message of biomedical research to Congress. Practice your new-found skills in mock congressional offi ce appointments.

Q NSF Grant Opportunities in Biological Sciences and Educational Activities 2:00 pm–3:00 pm Room 147

Q Learn about opportunities for NSF grant support from the Directorate for Biological Sciences and the Directorate for Education & Human Resources. Q Programs from both directorates that support research and education in cell biology will be highlighted. Q Tips will be offered for a successful proposal.

85 MONDAY The American Society for Cell Biology 47th Annual Meeting

December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

Q Afternoon Refreshment Break 2:30 pm–3:30 pm Halls A/B

Q Minisymposium 9 3:40 pm–5:45 pm Room 146 Apoptosis and Organelles Co-Chairs: Seamus J. Martin, Trinity College Dublin, Ireland, and Donald Newmeyer, La Jolla Institute for Allergy and Immunology 3:40 pm Introduction 3:45 pm 800 Bax or Bak-induced Mitochondrial Fission Can be Uncoupled from Cytochrome c Release. S. J. Martin; The University of Dublin, Trinity College, Dublin, Ireland 4:00 pm 801 Pro-apoptotic Bcl-2-family Proteins Produce Independent Responses at the Mitochondrial Outer and Inner Membranes. R. Yamaguchi, D. D. Newmeyer; La Jolla Institute for Allergy and Immunology, La Jolla, CA 4:15 pm 802 Role of Mitochondrial Remodeling in Programmed Cell Death in Drosophila melanogaster. G. Goyal,1 B. Fell,2 A. Sarin,1 R. Youle,2 V. Sriram1; 1National Centre for Biological Sciences, Bangalore, India, 2Biochemistry Section, Surgical Neurology Branch, National Institute of Neurological Disorders & Stroke/NIH, Bethesda, MD 4:30 pm 803 G1 to S Phase Cell Cycle Progression Requires a Single Electrically-coupled Mitochondrial Network with a Continuous Lumen. K. Mitra,1 B. Roysam,2 J. Lippincott-Schwartz1; 1National Institute of Child Health & Human Development/ NIH, Bethesda, MD, 2Department of Electrical, Computer, and Systems Engineering, Rensselaer Polytechnic Institute, Troy, NY 4:45 pm 804 A Novel Tail Anchored Mitochondrial Outer Involved in Mitochondrial Division. S. S. Gandre; Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 5:00 pm 805 The Role of Ceramide Channels in Mitochondria-mediated Apoptosis. M. Colombini,1 L. J. Siskind2; 1University of Maryland, College Park, MD, 2General Internal Medicine/Geriatrics, Medical University of South Carolina, Charleston, SC 5:15 pm 806 Bcl-XL Is Functionally Equivalent to a Dominant Negative Bax. L. P. Billen,1 C. L. Kokoski,1 J. F. Lovell,1 B. Leber,1,2 D. W. Andrews1; 1Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada, 2Medicine, McMaster University, Hamilton, ON, Canada 5:30 pm 807 Overlapping Cleavage Motif Selectivity of Caspases - Implications for Analysis of Apoptotic Pathways. G. P. McStay,1 G. S. Salvesen,2 D. R. Green1; 1Department of Immunology, St. Jude Children’s Research Hospital, Memphis, TN, 2Apoptosis & Cell Death Research Program, The Burnham Institute for Medical Research, La Jolla, CA

Q Minisymposium 10 3:40 pm–5:45 pm Ballroom C Supported by Cytoskeleton, Inc. Cell Migration/Motility Co-Chairs: Jeff Hardin, University of Wisconsin–Madison, and Irina Kaverina, Vanderbilt University Medical Center 3:40 pm Introduction 3:45 pm 808 Microtubule and Src Dynamics in Neuronal Growth Cones during Adhesion-mediated Guidance. A. Lee, B. Wu, D. M. Suter; Biological Sciences, Purdue University, West Lafayette, IN 4:00 pm 809 Role of Golgi-derived Microtubules in Post-Golgi Traffi cking and Polarized Cell Migration. P. M. Miller, I. Kaverina; Department of Cell/Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 4:15 pm 810 Vesicular Traffi cking and Protein Synthesis Are Required for Streaming during Chemotaxis. P. W. Kriebel,1 V. A. Barr,1 G. Zhang,2 C. A. Parent1; 1Laboratory of Cellular and Molecular Biology, National Cancer Institute/NIH, Bethesda, MD, 2Division of Bioengineering and Physical Sciences, National Institute of Biomedical Imaging and Bioengineering/NIH, Bethesda, MD 4:30 pm 811 Protein Domains of Cortactin Have Diverse Roles in the Formation, Dynamics, and Matrix Degradation of Invadopodia. M. G. Oser,1 H. Yamaguchi,2 J. Van Rheenen,1 C. Cortesio,3 A. Huttenlocher,3 J. Condeelis1; 1Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY, 2Laboratory of Genome and Biosignal, Tokyo University of Pharmacy and Life Science, Tokyo, Japan, 3Department of Pharmacology, University of Wisconsin–Madison, Madison, WI 4:45 pm 812 C. elegans Enabled in Epidermal Morphogenesis: Novel Interactions with N-WASP and Epithelial Junctions. M. Sheffi eld,1 T. Loveless,2 J. Pettitt,3 J. Hardin4; 1Program in Genetics, University of Wisconsin–Madison, Madison, 2 3 86 WI, Cellular and Molecular Biology Program, University of Wisconsin–Madison, Madison, WI, Department of The American Society for Cell Biology 47th Annual Meeting MONDAY

December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

Molecular and Cell Biology, University of Aberdeen, Aberdeen, United Kingdom, 4Department of Zoology, University of Wisconsin–-Madison, Madison, WI 5:00 pm 813 Actomyosin Contraction Builds Bridges between Adhesive Contacts. O. M. Rossier,1 E. R. Heller,1 A. Mathur,2 M. S. Koeckert,2 J. C. Hone,2 M. P. Sheetz1; 1Department of Biological Sciences, Columbia University, New York, NY, 2Department of Mechanical Engineering, Columbia University, New York, NY 5:15 pm 814 Analysis of Myosin II-induced Maturation of Focal Adhesions. A. Pasapera-Limon,1 I. Schneider,2 C. M. Waterman1; 1National Heart, Lung, and Blood Institute/NIH, Bethesda, MD, 2Cell Biology, The Scripps Research Institute, La Jolla, CA 5:30 pm 815 Novel Mechanism of Fibronectin Matrix Assembly by Regulation of Cadherin Adhesion and Tissue Tension via the Non-Canonical Wnt Signaling Pathway. B. Dzamba,1 M. Marsden,2 M. Schwartz,3 D. DeSimone1; 1Cell Biology, University of Virginia, Charlottesville, VA, 2Biology, University of Waterloo, Waterloo, ON, Canada, 3Microbiology, University of Virginia, Charlottesville, VA

Q Minisymposium 11 3:40 pm–5:45 pm Room 145 Mechanisms of Epigenetic Regulation Co-Chairs: Gary Felsenfeld, National Institute of Diabetes & Digestive & Kidney Diseases/NIH, and Cynthia Wolberger, Johns Hopkins School of Medicine/HHMI 3:40 pm Introduction 3:45 pm 816 Epigenetic Silencing of the Ribosomal Genes Is Essential for Effi cient Ribosome Biogenesis. T. Moss, T. Gagnon- Kugler, F. Langlois, F. Lessard, V. Y. Stefanovsky; Medical Biology and Cancer Research Centre, Laval University and CHUQ-HDQ, Quebec, PQ, Canada 4:00 pm 817 Insights into Transcriptional Silencing and Telomere Length Regulation from the Structure of the Rap1 C-terminus. E. A. Feeser, C. Wolberger; Department of Biophysics and Biophysical Chemistry, Johns Hopkins School of Medicine/ HHMI, Baltimore, MD 4:15 pm 818 Epigenetic Reprogamming by LSD1 Contributes to Germline Immortality in C. elegans. D. J. Katz, T. Edwards, W. G. Kelly; Biology Department, Emory University, Atlanta, GA 4:30 pm 819 Stability of Nucleosomes Containing Histone Variants H3.3 and H2A.Z. C. Jin, G. Felsenfeld; Laboratory of Molecular Biology, National Institute of Diabetes & Digestive & Kidney Diseases/NIH, Bethesda, MD 4:45 pm 820 The Complexity of Phosphorylated H2AX Foci and DNA Repair Protein Assembly at DNA Double-stranded Breaks. W. Bonner, A. Nakamura; Laboratory of Molecular Pharmacology, National Cancer Institute/NIH, Bethesda, MD 5:00 pm 821 Activated Estrogen Receptor Down-regulates Human E-cadherin Gene Expression. Y. N. Liu,1 Y. Liu, 2 J. H. Chen3; 1Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan, 2Department of Medicine, Tzu Chi University, Hualien, Taiwan, 3Institute of Molecular and Cellular Biology, Tzu Chi University, Hualien, Taiwan 5:15 pm 822 Nuclear Reprogramming in Xenopus. T. J. McGarry; Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 5:30 pm 823 Mallory Body Formation in the Livers of Drug-primed Mice Is Regulated by an Epigenetic Mechanism. F. Bardag- Gorce, J. Villegas, S. Fraley, J. Li, F. Amidi, J. Oliva, M. Joyce, B. French, S. W. French; Pathology, Harbor-UCLA Medical Center, Torrance, CA

Q Minisymposium 12 3:40 pm–5:45 pm Ballroom A Mechanisms of Membrane Traffi cking Co-Chairs: Juan Bonifacino, National Institute of Child Health & Human Development/NIH, and Elizabeth Conibear, University of British Columbia 3:40 pm Introduction 3:45 pm 824 In Vivo Visualization of Proteins Sorting upon ER Exit in S. cerevisiae. G. Castillon, H. Riezman; Biochemistry, Universite Sciences II, Geneva, Switzerland 4:00 pm 825 Non-vesicular Transport of Glucosylceramide via FAPP2 Is Required for Glycosphingolipid Synthesis and to the Plasma Membrane. M. De Matteis,1 G. D’Angelo,1 E. Polishchuk,1 G. Di Tullio,1 M. Santoro,1 A. Di Campli,1 Y. Hannun,2 A. van der Spoel,3 F. Platt,3 R. Polishchuk,1 P. Mattjus4; 1Cell Biology/Oncology, Consorzio Mario Negri Sud, Santa Maria Imbaro, Italy, 2Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina, 3Department of Pharmacology, University of Oxford, Oxford, United Kingdom, 4Biochemistry and Pharmacy, Åbo Akademi University, Turku, Finland

87 MONDAY The American Society for Cell Biology 47th Annual Meeting

December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

4:15 pm 826 The AP4 Complex Mediates Sorting of the Amyloid Precursor Protein at the trans-Golgi Network. P. V. Burgos, G. A. Mardones, L. L. daSilva, W. J. Smith, Y. Prabhu, J. S. Bonifacino; Cell Biology and Metabolism Branch, National Institute of Child Health & Human Development/NIH, Bethesda, MD 4:30 pm 827 Identifying New Components of the Early Endosome Retrograde Sorting Machinery in Saccharomyces cerevisiae. Y. C. Tam,1 M. Davey,1 F. D. Mast,2 A. Fagarasanu,2 R. Rachubinski,2 E. Conibear1; 1Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada, 2Department of Cell Biology, University of Alberta, Edmonton, AB, Canada 4:45 pm 828 Genome-wide Analysis Identifi es a General Requirement for Polarity Proteins in Endocytic Traffi c. B. D. Grant; Molecular Biology and Biochemistry, Rutgers Univeristy, Piscataway, NJ 5:00 pm 829 Loss of an Early Endocytic Compartment Positive for APPL1 and the Lowe Syndrome Protein OCRL upon Acute 1 2 1 2 1 Depletion of PI(4,5)P2 at the Plasma Membrane. R. Zoncu, R. M. Perera, D. M. Balkin, D. K. Toomre, P. De Camilli ; 1Cell Biology, Yale University/HHMI, New Haven, CT, 2Cell Biology, Yale University, New Haven, CT 1 2 5:15 pm 830 A Novel Role for PI(4,5)P2 in Eisosome Organization and Plasma Membrane Dynamics. C. Stefan, T. Walther, P. Walter,3 S. Emr1; 1Institute for Cell and Molecular Biology & Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY, 2Organelle Architecture and Dynamics, Max Planck Institute of Biochemistry, Martinsried, Germany, 3Howard Hughes Medical Institute & Department of Biochemistry and Biophysics, University of California, at San Francisco, San Francisco, CA 5:30 pm 831 Shiga Toxin-induced Tubular Membrane Invaginations for Clathrin-independent Uptake into Cells. W. Römer,1 L. Berland,2 V. Chambon,1 B. Windschiegl,3 K. Gaus,4 D. Tenza,1 M. R. E. Aly,5 V. Fraisier,1 J. Florent,5 C. Lamaze,1 G. Raposo,1 C. Steinem,3 P. Sens,6 P. Bassereau,2 L. Johannes1; 1UMR144, Institut Curie, Paris Cedex 05, France, 2UMR168, Institut Curie, Paris Cedex 05, France, 3Institut für Organische und Biomolekulare Chemie, Georg-August Universitat, Göttingen, Germany, 4Centre for Vascular Research, University of New South Wales, Sydney, Australia, 5UMR176, Institut Curie, Paris Cedex 05, France, 6Physico-Chimie Theorique, ESPCI, Paris Cedex 05, France

Q Minisymposium 13 3:40 pm–5:45 pm Ballroom B Molecular Motors: Alone and in Groups Co-Chairs: Gijsje Koenderink, Institute for Atomic and Molecular Physics, and Daniela Nicastro, Brandeis University 3:40 pm Introduction 3:45 pm 832 Structure and Function of Kinesin-13 Oligomeric Rings. D. Tan, V. Mennella, V. DePaoli, A. B. Asenjo, D. J. Sharp, H. Sosa; Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, NY 4:00 pm 833 *Post-translational Modifi cations of Microtubules Direct the Preferential Transport of Single Kinesin-1 Motors in Live Cells. D. Cai,1 N. A. Reed,1 E. Meyhofer,2 K. J. Verhey1; 1Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, 2Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI 4:15 pm 834 Microtubule Crosslinking Triggers the Directional Motility of Kinesin-5. L. C. Kapitein,1,2 B. H. Kwok,3 C. F. Schmidt,4,2 T. M. Kapoor,3 E. J. G. Peterman2; 1Department of Neuroscience, Erasmus Medical Center, Rotterdam, The Netherlands, 2Department of Physics and Astronomy, Vrije Universiteit, Amsterdam, The Netherlands, 3Laboratory of Chemistry and Cell Biology, Rockefeller University, New York, NY, 4Fakultät für Physik, Georg-August-Universität, Göttingen, Germany 4:30 pm 835 A Myosin Motor That Selects Bundled Actin. B. L. Ricca, S. Nagy, M. F. Norstrom, P. A. Smithback, R. S. Rock; Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL 4:45 pm 836 Myosin-activated Random Stress Fluctuations in the Actin Cytoskeleton. G. Koenderink,1 C. P. Brangwynne,2 M. Soares e Silva,1 F. C. MacKintosh,3 D. A. Weitz4; 1Institute for Atomic and Molecular Physics, Amsterdam, The Netherlands, 2Harvard School of Engineering and Applied Science, Harvard University, Cambridge, MA, 3Department of Physics and Astronomy, Vrije Universiteit, Amsterdam, The Netherlands, 4Harvard School of Engineering and Applied Science and Department of Physics, Harvard University, Cambridge, MA 5:00 pm 837 Structural Analysis of Dynamin Family Members Offers Insight into Membrane Fission. J. A. Mears, P. Ray, S. Fang, J. E. Hinshaw; Laboratory of Cell Biochemistry & Biology, National Institute of Diabetes and Digestive and Kidney Diseases/NIH, Bethesda, MD 5:15 pm 838 Cryo-Electron Tomography of the Cytoplasmic Dynein-Microtubule Complex. V. Tang, K. Okada, B. L. Goode, D. Nicastro; Biology Department and Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, MA 5:30 pm 839 Cytoplasmic Dynein Is a Better Navigator than Kinesin on Tau-decorated Microtubules. R. Dixit, J. L. Ross, Y. E. Goldman, E. L. F. Holzbaur; Physiology, University of Pennsylvania, Philadelphia, PA *Gilula Award Winner 88 The American Society for Cell Biology 47th Annual Meeting MONDAY

December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

Q Minisymposium 14 3:30 pm–5:45 pm Room 207 Nuclear Import and Export Co-Chairs: Charles N. Cole, Dartmouth Medical School, and Richard W. Wozniak, University of Alberta 3:40 pm Introduction 3:45 pm 840 The Role of the Ndc1 Complex in Nuclear Pore Complex Assembly. E. A. Onischenko,1 L. Stanton,1 A. S. Madrid,1 T. Kieselbach,2 K. Weis1; 1Department of Molecular/Cell Biology, University of California, Berkeley, Berkeley, CA, 2Department of Biochemistry, Umea University, Umea, Sweden 4:00 pm 841 Regulation of Lamin Assembly by Importins. S. A. Adam,1 K. Sengupta,1 N. Muecke,2 D. Moeller,2 H. Herrmann,2 R. D. Goldman1; 1Cell and Molecular Biology, Northwestern University Feinberg School of Medicine, Chicago, IL, 2Deutsch Krebbsforschung Zentrum, Heidelberg, Germany 4:15 pm 842 Selective Gating in the Nuclear Pore Complex Dissected at the Single-Event Level. R. Y. H. Lim,1 B. Fahrenkrog,1 J. Koeser,1 K. Schwarz-Herion,1 J. Deng,2 U. Aebi1; 1Biozentrum, University of Basel, Basel, Switzerland, 2Institute of Materials Research and Engineering, Singapore 4:30 pm 843 CAS Is Required for Dissociation of Importin Alpha/Cargo Complexes at the Nuclear Pore Complex. C. Sun, W. Yang, S. Musser; Molecular and Cellular Medicine, The Texas A&M Health Science Center, College Station, TX 4:45 pm 844 Export of the 60S Ribosomal Subunit Requires Nucleoporin FG-domains That Overlap with both Karyopherin and mRNA Export Pathways. E. B. Shows, S. R. Wente; Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 5:00 pm 845 Nuclear Export of the Large Ribosomal Subunit in Yeast Requires Multiple Receptors. N. Hung, K. Lo, K. Helmke, A. W. Johnson; Molecular Genetics and Microbiology, University of Texas at Austin, Austin, TX 5:15 pm 846 Microtubule/Dynein-dependent Nuclear Protein Import Pathway for Cancer Regulatory and Viral Proteins. G.W. Moseley,1 D. M. Roth,1 M. A. DeJesus,1 D. L. Leyton,1 R. P. Filmer,1 C. W. Pouton,2 D. A. Jans1; 1Biochemistry and Molecular Biology, Monash University, Melbourne, Australia, 2Victorian College of Pharmacology, Monash University, Melbourne, Australia 5:30 pm 847 The Molecular Mechanism of Differential SUMO Modifi cation. S. Zhu, M. J. Matunis; Biochemistry and Molecular Biology, School of Public Health/Johns Hopkins University, Baltimore, MD

Q Minisymposium 15 3:40 pm–5:45 pm Room 147 Prokaryotic Cell Biology Co-Chairs: Zemer Gitai, Princeton University, and David Z. Rudner, Harvard Medical School 3:40 pm Introduction 3:45 pm 848 Regulating the Polymerization of a Bacterial Actin Homolog, MreB, from Caulobacter crescentus. N. A. Dye,1 J. A. Theriot,1 L. Shapiro2; 1Biochemistry, Stanford University, Stanford, CA, 2Developmental Biology, Stanford University, Stanford, CA 4:00 pm 849 *In Vitro and In Silico Reconstitution of DNA Segregation: A 3 Component, Kinetically Self-contained Plasmid DNA Segregating Spindle. E. C. Garner,1 C. C. Campbell,1 J. B. Alberts,2 L. O. Trichet,3 H. Lee,4 R. D. Mullins1; 1Biochemistry, University of California, San Francisco, San Francisco, CA, 2Center for Cell Dynamics, University of Washington Friday Harbor, Friday Harbor, WA, 3Institut Curie-Section de Recherche, Paris, France, 4Applied Physics, California Institute of Technology, Pasadena, CA 4:15 pm 850 Genome-Scale Analysis of Protein Localization in an Asymmetric Bacterium. J. Werner, J. Guberman, Z. Gitai; Department of Molecular Biology, Princeton University, Princeton, NJ 4:30 pm 851 The Effect of the Environment on Cell-to-Cell Signaling in 3D Heterotypic, Bacterial Microarrays. U. M. Mirsaidov,1 W. Timp,2 M. Mir,1 P. Matsudaira,2 G. Timp1; 1Beckman Institute, University of Illinois–Urbana, Urbana, IL, 2Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, MA 4:45 pm 852 Post-Cytokinetic DNA Segregation by ATPases That Form DNA-Conducting Channels. B. M. Burton,1 K. Marquis,2 N. L. Sullivan,2 T. A. Rapoport,1 D. Z. Rudner2; 1Cell Biology, Harvard Medical School, Boston, MA, 2Harvard Medical School, Boston, MA 5:00 pm 853 SpoIIIE Strips Proteins off the DNA during Chromosome Translocation. D. Rudner,1 K. Marquis,1 B. Burton,2 N. Sullivan,1 T. Rapoport,2 S. Ben-Yehuda3; 1Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA, 2Department of Cell Biology, Harvard Medical School, Boston, MA, 3Department of Molecular Biology, The Hebrew University of Jerusalem, Jerusalem, Israel

89 MONDAY The American Society for Cell Biology 47th Annual Meeting

December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

5:15 pm 854 Maintenance of Polarity and Cell Shape in Vibrio cholerae. H. Lam, M. Waldor; Medicine and Microbiology, Brigham and Women’s Hospital/Harvard Medical School, Boston, MA 5:30 pm 855 **Intrinsic Mechanisms Involved in Cell Polarization in Caulobacter crescentus. C. Jacobs-Wagner, G. Ebersbach, H. Lam; Molecular, Cellular & Developmental Biology, Yale University, New Haven, CT *Bernfi eld Award presentation **Women in Cell Biology Junior Awardee

Q Minisymposium 16 3:40 pm–5:45 pm Room 202 X-ylation and Cell Signaling Co-Chairs: Holly A. Ingraham, University of California, San Francisco, and Kim Orth, University of Texas Southwestern Medical Center 3:40 pm Introduction 3:45 pm 856 Regulation of NR5A Nuclear Receptor Activity via SUMO Modifi cation. L. A. Campbell,1 M. A. Show,2 J. G. Ingraham,2 D. M. Kurrasch,2 J. Flinders,3 J. D. Gross,3 H. A. Ingraham2; 1Graduate Program in Biological Sciences, Department of Physiology, University of California, San Francisco, San Francisco, CA, 2Department of Physiology, University of California, San Francisco, San Francisco, CA, 3Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 4:00 pm 857 PDGF Receptor Signaling and Degradation Is Regulated through PI3K Interaction with Ankyrin3, a Ubiquitin Binding Adapter Protein. L. A. Furber,1,2 P. H. Links,1 O. C. Jennifer,1,2 S. F. Poland,1,2 A. D. Hawrysh,1 D. H. Anderson1; 1Cancer Research Unit, Saskatchewan Cancer Agency, Saskatoon, SK, Canada, 2Department of Biochemistry, University of Saskatchewan, Saskatoon, SK, Canada 4:15 pm 858 O-GlcNAc Transferase Modulates PI3K and MAPK Pathways to Resist Stress. S. Ho,1 K. Wang,2 T. R. Whisenhunt,3 F. Zhang,3 P. Huang,4 J. E. Kudlow,3,1,2 A. J. Paterson3,1,2; 1Cell Biology, University of Alabama at Birmingham, Birmingham, AL, 2Physiology & Biophysics, University of Alabama at Birmingham, Birmingham, AL, 3Medicine, University of Alabama at Birmingham, Birmingham, AL, 4Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, AL 4:30 pm 859 Effects of O-GlcNAcase on Insulin Signaling in Adipocytes. C. N. Keembiyehetty, E. J. Kim, D. C. Love, J. Hanover; Lab of Cell Biochemistry and Biology, National Institute of Diabetes and Digestive and Kidney Diseases/NIH, Bethesda, MD 4:45 pm 860 Loss of Tubulin Polyglutamylation Is Associated with a Lack of Central Apparatus in Trachea Cilia Axoneme, Dysregulated Cilia Beating, and Severe Ceaseless Cough in TTLL1-defi cient Mouse. K. Ikegami,1 S. Sato,1 M. Setou1,2; 1MITILS, Machida, Japan, 2NIPS, Okazaki, Japan 5:00 pm 861 Myristoylation of Zebrafi sh Naked Is Required to Antagonize Both Canonical Wnt/β-catenin and Non-canonical Wnt/PCP Signaling. T. Van Raay,1,2 L. Solnica-Krezel,1 R. J. Coffey2; 1Biological Science, Vanderbilt University, Nashville, TN, 2Medicine, Vanderbilt University Medical Center, Nashville, TN 5:15 pm 862 Regulation of Cytoskeleton and Cell Signaling by Posttranslational Arginylation. C. C. L. Wong,1 T. Xu, 1 R. Rai,2 S. Saha,2 A. O. Bailey,3 J. R. Yates,1 Y. I. Wolf,4 H. Zebroski,5 A. Kashina2; 1The Scripps Research Institute, La Jolla, CA, 2Department of Animal Biology, University of Pennsylvania, Philadelphia, PA, 3University of Virginia School of Medicine, Charlottesville, VA, 4National Institutes of Health, Bethesda, MD, 5Rockefeller University, New York, NY 5:30 pm 863 Biochemical Characterization of Type III-secreted Bacterial Acetyltransferases. O. Lee,1 K. Orth2; 1University of Texas Southwestern Medical Center, Dallas, TX, 2Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX

90 The American Society for Cell Biology 47th Annual Meeting MONDAY

December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

Q Practice of Science 5:30 pm–6:30 pm Room 143 A/B Challenges and Opportunities for NIH Peer Review

Mary Beckerle Katherine Wilson Keith Yamamoto University of Utah Johns Hopkins University University of California, San Huntsman Cancer Francisco Institute

Biological research is a remarkably dynamic enterprise, and the processes for reviewing and supporting that endeavor must keep pace. As part of a comprehensive review of the National Institutes of Health’s system of research support, NIH Director Elias Zerhouni has formed the Peer Review Working Group of the Director’s Advisory Committee to seek advice from the scientifi c community, and to propose pilot experiments and policy changes. Join Working Group Co-Chair Keith Yamamoto, Mary Beckerle, Kathy Wilson, and others for a review of the efforts of the Working Group. An open discussion will follow in which you can contribute your own ideas for changes in grants mechanisms and peer review.

Q Tutorials 6:00 pm–7:30 pm

See description of Tutorials at the end of the Monday section.

91 MONDAY The American Society for Cell Biology 47th Annual Meeting

December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

Q Women in Cell Biology (WICB) Committee Evening Program & Awards Presentation 6:30 pm–8:00 pm Room 147 Presentation of WICB Awards

Junior Awardee Senior Awardee Christine Jacobs-Wagner Yale University University of California, San Francisco

WICB Evening Program But I Have a Family!

The Evening Program will: Q Highlight the issues that impact a cell biologist’s career that revolve around having a family Q Have ASCB “Thespians” spoof some of the issues faced by cell biologists in combining family and professional life Q Be empanelled to comment on challenges and solutions enabling cell biologists to be successful in both career and home Q Take questions and comments from the audience

Caroline Kane Wallace Marshall Sandra Masur Timothy J. Mitchison University of California, University of California, Mount Sinai School of Harvard University Berkeley San Francisco Medicine

92 The American Society for Cell Biology 47th Annual Meeting MONDAY

December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

EXHIBITOR SHOWCASES WASHINGTON CONVENTION CENTER

Thermo Scientifi c Dharmacon Products 7:00 am–9:00 am, Room 206 PerkinElmer 7:00 am–7:30 am, Room 201 Innovative Technology that Enables RNAi in Diffi cult-to-Transfect A Superior Alternative to Western Blot: Phospho-Kinase Detection in Cells Cells Using AlphaScreen® SureFire™ Level: Intermediate Level: Intermediate Presenter: Christina Yamada Presenter: Graham S. Long Thermo Scientifi c Dharmacon Products PerkinElmer 2650 Crescent Drive, Suite 100 710 Bridgeport Avenue Lafayette, CO 80026 Shelton, CT 06484 Phone: (800) 235-9880 Tel: (203) 402-6876 Fax: (303) 604-9680 Fax: (203) 944-4950 www.thermo.com/dharmacon www.perkinelmer.com

Delivery remains one of the last barriers for applying RNA interfer- Are you interested in an effective tool for the rapid and sensitive detec- ence (RNAi) in clinically relevant cell lines. Recent investigations at tion of phosphorylated endogenous cellular proteins in a homogeneous, Thermo Fisher Scientifi c have led to the development of an innovative no wash format? The AlphaScreen® SureFire™ suite of cellular kinase molecule for lipid-independent delivery in a wide variety of cell types. assays are non-radioactive, low volume assays that offer many advan- These modifi ed siRNAs have been found to effectively silence target tages over more laborious and potentially less sensitive assay systems genes in cell types that are typically diffi cult to transfect using standard such as Western Blots and ELISA. This presentation will describe the delivery methods. We will present data for multiple cell types including various applications of the AlphaScreen® SureFire™ approach for SHSY-5Y (neuroblastoma), Jurkats (T-cells), and primary astrocytes. analysis of a variety of receptor functions and their signal transduc- The combination of this technology and RNAi allows for functional tion pathways, which include assays for the major MAP kinases, many genomic studies in pertinent cell types. Moreover, cells can be continu- pathway intermediates involved in PI3-kinase signaling and JAK/STAT ously dosed with these siRNAs, thus enabling knockdown of any target signaling. These novel and simple to use assays provide a powerful gene of interest for extended durations in multiple cell types. means for researchers and drug discovery scientists to study numerous diseases and cellular signaling systems.

PerkinElmer 7:30 am–8:00 am, Room 201 Luminescence Reporter Gene Assays Level: Intermediate Presenter: Amy E. McCann ASCB Members Are Invited to Attend PerkinElmer The ASCB Business Meeting 710 Bridgeport Avenue Shelton, CT 06484 and Interactive Forum Tel: (203) 402-6876 Fax: (203) 944-4950 www.perkinelmer.com Tuesday, December 4, 12:00 Noon-1:00 pm Washington Convention Center, Reporter genes are used to monitor gene expression in cell culture. Room 158 A/B Re-engineering DNA response elements by adding a DNA sequence coding for luciferase allows one to create a reporter gene system indica- tive of a specifi c signaling pathway. In this way, a reporter gene system • Meet the ASCB Offi cers and Staff can be constructed to measure GPCR activity through luminescence generated by luciferase. We will discuss such a system, which features • Learn About the ASCB’s 2007 Activities the reliability and convenience of a luciferase reporter system with the • Hear About ASCB Plans for 2008 effi ciency of our low cost multimodal VICTOR® plate reader. • Ask About How You Can Get Involved • Cast Your Vote

93 MONDAY The American Society for Cell Biology 47th Annual Meeting

December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

EXHIBITOR SHOWCASES WASHINGTON CONVENTION CENTER

PerkinElmer 8:00am–8:30 am, Room 201 GE Healthcare 9:15 am–11:15 am, Room 201 Phosphorylation Site Analysis in Complex Samples without the Use Protein Enrichment or Purifying Tagged Proteins—Getting It Right of Antibodies From the Start and Reaching the Finish Line With Reproducible Level: Advanced Results Presenter: Wayne F. Patton Level: Advanced PerkinElmer Presenters: Lena Jonsson and Marianne Carlsson 710 Bridgeport Avenue GE Healthcare Shelton, CT 06484 800 Centennial Avenue Tel: (203) 402-6973 Piscataway, NJ 08854 Fax: (203) 944-4950 Phone: (800) 526-3593 www.perkinelmer.com Fax: (877) 295-8102 www.gelifesciences.com Protein phosphorylation is crucial to regulation of cell signaling pathways. An antibody-free process workfl ow for phosphorylation Athletes train diligently in advance of the race to achieve the desired site analysis is described involving orthogonal phosphomonoester- results—the fi nish line in record time. Protein sample preparation is selective binding strategies. First, complex protein samples, such as the “training” for the planned analysis procedure and desired reproduc- rat kidney cytosol proteins, are enriched by phosphoprotein affi nity ible results. This can be accomplished by: enhancement of the specifi c chromatography and separated by conventional gel electrophoresis. protein signal through immunoprecipitation and one-dimensional Phosphoproteins are detected with a selective stain that binds to the electrophoresis analysis; desalting or buffer exchange of a protein, phosphomonoester dianion moieties of serine, threonine, and tyrosine carbohydrate, or peptide solution can be required for a wide variety residues at neutral pH. Then, phosphoprotein bands are excised and of analyses, affi nity tags used to simplify the purifi cation, increase subjected to proteolytic digestion. Constituent phosphopeptides are the purity and yield of recombinant proteins; and proteins tagged subsequently purifi ed using titanium dioxide thin-fi lm coated magnetic with histidine (His), maltose binding protein (MBP), glutathione beads at acidic pH. Phosphopeptides are eluted at alkaline pH and S-transferase (GST), or Strep(III). Several application examples will directly characterized by MALDI-TOF or tandem mass spectrometry be shown together with some hints and tips on how to obtain pure without chemical modifi cation by methyl esterifi cation. Identifi cation protein quickly and easily. is readily performed from as little as 78 fmol of starting material. Carl Zeiss Microimaging, Inc. 9:15 am–9:55 am, Room 206 PerkinElmer 8:30 am–9:00 am, Room 201 Optical Coherence Tomography for Rapid Volumetric Imaging HCS, Live Cell Imaging, and 4D Image Analysis—Your Science, Our Level: Advanced Solutions Presenter: Joseph A. Izatt Level: Intermediate Carl Zeiss MicroImaging, Inc. Presenter: Jürgen Kupper One Zeiss Drive PerkinElmer Thornwood, NY 10594 710 Bridgeport Avenue Phone: (800) 233-2343 Shelton, CT 06484 Fax: (914) 681-7445 Tel: (203) 402-6973 www.zeiss.com/micro Fax: (203) 944-4950 www.perkinelmer.com Optical coherence-based imaging techniques such as optical coherence tomography (OCT) use low-coherence spectral interferometry to ob- The Cellular Imaging and Analysis business unit of PerkinElmer, Inc., tain nanometer- to micron-scale measurements of structure, motion, combines expertise in confocal imaging, high content screening, and im- and molecular composition in living cells, tissues, and organisms. age analysis software. A choice of products is offered in each application Recent dramatic technology advances have increased the performance so that scientists can choose the best solution for their experiments. Our of OCT systems manyfold, and they are now capable of micron-scale confocal imaging solutions include the latest in spinning disk technology two and three-dimensional functional and molecular imaging noninva- for exceptional high speed, live cell imaging, with integrated acquisition sively in living systems. Applications of these new technologies include and analysis provided by Volocity software. The HCS Opera products high-throughput phenotyping of small animal models of disease and offer fully automated high speed, high resolution screening for a wide genetic manipulation. Related technology advances have enabled the variety of cellular assays. A range of image analysis software is available design of highly phase-stable interference microscopes capable of for both online and offl ine applications, from high resolution multi- resolving nanometer-scale structures and motions in living cells with dimensional imaging to automated cell assay analysis. In this presenta- ms temporal resolution. These new capabilities are being used to probe tion we discuss our portfolio of products and the ways in which we can cellular internal and external surfaces and their responses to chemical support cellular research both now and in the future. and mechanical stimuli.

94 The American Society for Cell Biology 47th Annual Meeting MONDAY

December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

EXHIBITOR SHOWCASES WASHINGTON CONVENTION CENTER

Carl Zeiss Microimaging, Inc. 9:55 am–10:35 am, Room 206 Applied Biosystems 11:30 am–12:30 pm, Room 201 High-throughput Image Analysis for Spectroscopy-based Measurements The Latest Advances in siRNA Technologies to Examine RNA Splicing and Protein-Protein Interactions Level: Intermediate Level: Intermediate Presenter: Steve Suchyta Presenters: Cameron H. J. Cooper, Miranda D. Smith, Scot Harms, Applied Biosystems Paul Rupp, Heather Cartwright, Marco Blanchette, Paul Kulesa, and 850 Lincoln Centre Drive Joel W. Schwartz Foster City, CA 94404 Carl Zeiss MicroImaging, Inc. Phone: (650) 638-5041 One Zeiss Drive Fax: (650) 638-5884 Thornwood, NY 10594 www.appliedbiosystems.com Phone: (800) 233-2343 Fax: (914) 681-7445 Critical to siRNA experimental success is use of effective, potent, and www.zeiss.com/micro specifi c siRNAs for silencing the selected targets. We will discuss the latest advances in siRNA technologies that result in improved and Image cytometry is an extremely powerful tool to examine and charac- more consistent target gene knockdown with fewer off-target effects. terize a large number of images. To date, many measurements are often A simple workfl ow for siRNA validation performed using real-time restricted to two-dimensional objects evaluated using specialized high- PCR and TaqMan® Gene Expression Assays, as well as results from throughput machines examining classic intensity-based morphometric our own siRNA validation efforts, will be presented. Finally, we will parameters. Here we describe several different approaches to modify briefl y introduce two new interactive tools for performing systems biol- traditional research microscopes to produce a large number of images, ogy. The GeneAssist™ Pathway Atlas enables searching and browsing using a wide variety of imaging techniques not currently available to of protein and gene information by biological pathway, whereas the traditional plate reading systems. Using a combination of AssayBuilder GeneAssist™ siRNA Workfl ow Builder provides a unique interface for by Zeiss/Cellomics and novel microscopies, we have established the selecting the right reagents for each step of the RNAi workfl ow. appropriate stage, setup, and sample chamber modifi cations to perform semi-automated image acquisition. BD Bioscience 11:30 am–12:30 pm, Room 206 We provide an overview that encompasses the following biological Separation of Mammalian Organelles and Macromolecular Machines examples to address genes related to protein splicing via a GFP/RFP by FFE reporter assay and protein-protein interactions via anisotropy-based Level: Advanced FRET measurements. We also discuss the use of multispectral imag- Presenter: Oliver Drews ing and specialized sample chambers to permit the immobilization of BD Biosciences non-adherent samples. In conclusion, we have developed a set of tools 10975 Torreyana Road that permit the adaptations of commercial software to collect images San Diego, CA 92121 of non-traditional samples and approaches for image cytometry. Phone: (858) 812-8940 Fax: (858) 812-8995 Carl Zeiss Microimaging, Inc. 10:35 am–11:15 am, Room 206 www.bdbiosciences.com Single Cell Analysis of Stem Cell Fate Regulation Studied by Laser Microdissection and Time Lapse Microscopy (PALM) Considerable evidence in the literature suggests the existence of Level: Introductory heterogeneous populations of protein complexes and organelles in Presenter: Regis Doyonnas mammalian cells. However, it remains largely unknown whether such Carl Zeiss MicroImaging, Inc. subpopulations possess structural differences, and moreover, exhibit One Zeiss Drive functional signifi cance in disease phenotypes. A rate-limiting step to Thornwood, NY 10594 pursue this line of investigation is a technology to effectively separate Phone: (800) 233-2343 those subpopulations. To this end, we successfully accomplished studies Fax: (914) 681-7445 to evaluate whether the free fl ow electrophoresis (FFE) technology is a www.zeiss.com/micro suitable solution. Using FFE as the platform technology, proteasome complexes as well as mitochondria purifi ed to apparent homogeneity Study of cell fate regulation at the single cell level. The dynamic behav- were separated in subpopulations. Proteomic and functional analyses ior of individual stem cells is being followed in hydrogel microwells in demonstrated that the subpopulations were indeed structurally and a dynamic manner by time lapse microscopy. Exposure of stem cells functionally distinct. The potential to distinguish between subpopula- to well-defi ned tethered or soluble proteins using novel technologies tions provides the foundation for more accurate functional analyses of infl uences cell fate, leading to self renewal or specialization. Using these cellular components. laser microdissection, cells can be recovered for further microscopic, culture, or molecular analysis.

95 MONDAY The American Society for Cell Biology 47th Annual Meeting

December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

EXHIBITOR SHOWCASES WASHINGTON CONVENTION CENTER

Applied Biosystems 12:30 pm–1:30 pm, Room 201 analysis of miRNA function. These tools will greatly increase the Getting Started with miRNA Analysis chances for a successful functional miRNA experiment. Level: Introductory Presenter: Steve Suchyta BD Biosciences 12:30 pm–1:30 pm, Room 206 Applied Biosystems Introducing the New BD AccuCell™ Automated Cell Counter 850 Lincoln Centre Drive Level: Introductory Foster City, CA 94404 Presenter: Patricia Daggett Phone: (650) 638-5041 BD Biosciences Fax: (650) 638-5884 Two Oak Park Drive www.appliedbiosystems.com Bedford, MA 01730 Phone: (877) 232-8995 miRNAs regulate gene expression by binding specifi c mRNAs and Fax: (800) 325-9637 modulating their translation and stability. The hundreds of unique www.bdbiosciences.com miRNAs expressed in humans likely affect expression of >50% of hu- man proteins. To improve understanding of the roles miRNA play in The BD AccuCell™ Automated Cell Counter is an automated, cost- human disease, we developed methods and reagents to isolate, detect, effective cell counting system that utilizes a disposable cell counting profi le, mimic, and inhibit endogenous miRNAs. These technologies chamber and analysis software. This system will allow rapid and ac- enable rigorous profi ling and functional analyses of miRNAs in com- curate eukaryotic cell counting and distinguishes viable from nonviable plex biological systems, including living mammals. Functional miRNA cells. Imaging technology allows for rapid cell counting and displays experiments can be diffi cult due to the lack of ability to detect delivery the cell images, which can be saved in TIFF or JPEG formats. This of functional molecules. We have developed several tools that enable system eliminates the need for manually counting cells by a hemocy- optimization of transfection of synthetic miRNAs and subsequent tometer, which is labor intensive and subject to human variability. This system also eliminates the need for glass disposal as well as harmful chemicals that are used in other types of large and cumbersome cell counting systems.

American Qualex/ International Qualex Flow Cytometry Systems/ Molecular Cytometry Systems 1:45 pm–3:45 pm, Room 206 Functional Assays and Products (Cytotoxicity/Cell Proliferation/ Capase Detection) Using Flow Cytometry; Patented MOL-PCRTM Multiplex Assays for Genotyping (SNP) and Custom Services Using Fluorescence and Nonphotobleaching Dyes Level: Intermediate Presenters: Michael Olin, Richard A. Vierling, and Daniel Moothart

American Qualex /International Qualex Flow Cytometry Systems/ Molecular Cytometry Systems 920 Calle Negocio, Suite A San Clemente, CA 92673 Phone: (949) 492-8298 Fax: (949) 492-6790 www.iqualex.com

This Showcase will include several interactive presentations on easy to use, innovative products and services to help solve problems in immu- nological and molecular multiplexed assays. International Qualex Flow Cytometry Systems (IQFCS) was created to support fl ow cytometry based immunological assays, assay development, custom services, and innovative technical support for fl ow cytometry products and their ap- plications. IQFCS specializes in: functional assays including cytotoxic- ity, cell proliferation assays, cell permeant apoptosis detection reagents for in-vitro, ex-vivo, capsase detection, optimized in-vivo caspase

96 MBL Biological Discovery in Woods Hole

Founded in 1888 as the Marine Biological Laboratory 2008 Summer Research Fellowships

Funding Available for Summer Research in Neuroscience APPLICATION DEADLINE: JANUARY 15, 2008

The MBL is pleased to announce the availability of funding for the following summer research programs in Neuroscience in 2008. These programs will provide up to $50,000/year/award with a possibility for renewal for 3 years. As participants in the MBL’s new Neuroscience Institute, scholars in these programs will benefit from the rich intellectual and interactive environment of the scientific community at the MBL.

ALBERT AND ELLEN GRASS FACULTY GRANTS PROGRAM Proposals must describe collaborative research in any area of neuroscience by teams of two or more investigators, with a minimum stay of six weeks at the MBL in Woods Hole. The intent of the program is to attract new investigators to the MBL at the assistant, associate, or full professor levels. The collabora- tive research can be between new teams of investigators or between new investigators who wish to collaborate with a more established investigator.

Requests will also be considered for collaborative research projects at the MBL during the off-season period. Funds may be used for laboratory and equipment rentals, supplies, and incidental expenses, housing and travel costs.

DART FOUNDATION SCHOLARS PROGRAM IN LEARNING & MEMORY Proposals must be targeted to the study of learning and memory with a minimum stay of six weeks at the MBL. Applications are encouraged from junior- or senior-level neuroscientists holding a Ph.D., M.D. or equivalent degree. Awards provide funds for research and laboratory rental, and cover the costs of housing and travel.

Funding Available for Summer Research APPLICATION DEADLINE: JANUARY 15, 2008

The MBL is pleased to announce the availability of funding for the following summer research programs in 2008 for junior or senior investigators holding a Ph.D., M.D., or equivalent degree. These prestigious awards provide funds for research and housing. Proposals for fellowship support will be considered in, but are not limited to, the following fields of investigation:

Cellular & Molecular Physiology Neurobiology Parasitology Molecular Biology Innate Immunity Microbiology Developmental Biology Ecology Tissue Engineering

For application forms and information, contact: Fellowships Coordinator: [email protected] or call Lenny Dawidowicz, 508.289.7268; MBL, 7 MBL Street, Woods Hole, MA 02543.

Applications are encouraged from women and members of underrepresented minorities. The MBL is an Equal Opportunity/ Affirmative Action Employer.

www.MBL.edu/fellowships NEW FIFTH EDITION Molecular Biology of THE CELL BRUCE ALBERTS • ALEXANDER JOHNSON • JULIAN LEWIS • MARTIN RAFF • KEITH ROBERTS • PETER WALTER

STUDENT VERSION For nearly a quarter century • More portable: Chapters 1-20 are printed and Molecular Biology of the Cell Chapters 21-25 are provided as PDF fi les on the free has been the leading cell Media DVD-ROM which accompanies the book. biology textbook. This • Now contains end-of-chapter problems for Chapters 1-20. tradition continues with the • Accompanying Media DVD-ROM contains over new Fifth Edition, which has 4 hours of animation and videos. been completely revised and • Integration of Media Codes throughout the text updated to describe our that link to relevant videos and animations. current, rapidly advancing • Media DVD-ROM also contains the fi gures from the book in PowerPoint® and J-PEG formats. understanding of cell biology. December 2007: 8-3/8 x 10-7/8: 1,392pp: 1,526 illus To list but a few examples, Hardback: 978-0-8153-4105-5: $142.00 new material is presented on: PACKAGED WITH A MEDIA DVD-ROM • Epigenetics REFERENCE EDITION • Stem cells • Ideal for libraries, laboratories, and researchers. • RNAi • Alternative to the student version: provides the • Comparative genomics complete text of Chapters 1-25 in printed format. • Accompanying Media DVD-ROM contains over • The latest cancer therapies 4 hours of animation and videos. • Apoptosis (now its own • Glossary containing over 1,300 entries. separate chapter) • Media DVD-ROM also contains the fi gures from • Cell cycle control and the the book in PowerPoint® and J-PEG formats. December 2007: 8-3/8 x 10-7/8: 1,728pp: 1,891 illus mechanics of M phase (now Hardback: 978-0-8153-4111-6: $209.00 integrated into one chapter) PACKAGED WITH A MEDIA DVD-ROM

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The University of Miami, Nature Publishing Group, and Scripps Florida present REGULATORY RNA IN BIOLOGY AND HUMAN HEALTH

Even though the key mechanisms and molecules involved in the biogenesis of small non-protein encoding RNAs and their role in regulating gene expression and genome stability are just beginning to be unraveled, RNA interference has already been widely adopted as a powerful approach for experimental knockdown of gene expression. A wide group of researchers working in RNA interference, X-chromosome inactivation and naturally occurring antisense transcripts will look at how these advances are being applied to create a new generation of therapeutics and diagnostics.

February 2–6, 2008 Miami Beach, Florida, USA Topics Mechanism of Action Novel Regulatory RNA Biogenesis of Regulatory RNA Regulatory RNA in Development & Disease Regulatory RNA and Cancer Biology RNA as Therapeutics & Diagnostics

Awardees Susan Gottesman, Feodor Lynen Lecturer David P. Bartel, Distinguished Service Awardee Phillip A. Sharp, Lifetime Achievement Awardee David C. Baulcombe, Special Achievement Awardee

Speakers E. Gerhart Wagner • Robin Allshire Ronald R. Breaker • K. Nishikura • Pamela J. Green Nikolaus Rajewsky • Phillip D. Zamore Leemor Joshua-Tor • Jeannie T. Lee • Gisela Storz Witold Filipowicz • Ramin Shiekhattar Markus Stoffel • Eric N. Olson • G. Ruvkun Frank J. Slack • Carlo M. Croce • S.M. Hammond Stephen W. Fesik • Luigi Naldini • Judy Lieberman

Important deadlines Travel Fellowship Awards: October 29, 2007 Short Reports for Posters: November 5, 2007 Short Oral Presentations will be selected from the posters

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1Mitalipov SM, et al. Reprogramming following somatic cell nuclear transfer in primates is dependent upon nuclear remodeling. Hum Reprod. 2007 Aug;22(8):2232-42 Large image of Rhesus monkey oocyte after enucleation courtesy S Mitalipov, OHSU, Portland, OR; Oosight and Conventional images courtesy Ng SC, NUS, Singapore. The American Society for Cell Biology 47th Annual Meeting MONDAY

December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

EXHIBITOR SHOWCASES WASHINGTON CONVENTION CENTER detection, high throughput drug screen assays, and nonphotobleach- Invitrogen 4:00 pm–6:00 pm, Room 206 ing fl uorescent probes. Molecular Cytometry Systems will present its Invitrogen range of products and services based upon its patented MOL-PCR™ 1600 Faraday Avenue Genotyping (SNP) detection systems for multiplex molecular assays. Carlsbad, CA 92008 Unable to attend? Visit Booth #1115 for a handout. Phone: (800) 955-6288 Fax: (760) 603-7229 Leica Microsystems 1:45 pm–3:45 pm, Room 201 www.invitrogen.com Advances in Confocal Imaging Technology: Nano-to-Macro Level: Introductory Part 1: Advanced Transfection Solution for Hard to Transfect Cells Presenters: Stephan Sigrist, Martin Hoppe, and Peter Sendrowski Level: Intermediate Leica Microsystems, Inc. Presenter: Laura Vozza-Brown 2345 Waukegan Road Transfection is an essential tool for in-vitro applications including Bannockburn, IL 60015 studies of gene expression, promoter analysis, intracellular signaling Phone: (800) 248-0123 pathways, epigenetics, and therapeutic strategies such as tissue engi- Fax: (847) 236-3009 neering and gene therapy. Increasing numbers of these applications are www.leica-microsystems.com moving to primary cell cultures, stem cells, and disease-relevant cell lines, which present signifi cant challenges to achieving required levels Leica Microsystems is proud to introduce advancements in “nano” and of transgene expression for reliable data analysis. Lipofectamine™ LTX “macro” confocal imaging for the life science researcher. Dr. Stephan is a reagent that provides high transfection effi ciency and high levels Sigrist, Professor at the ZEM Bio-Imaging Center of Wuerzburg, of expression in a number of mammalian cell types using a simple Germany, will discuss research applications for STimulated Emission protocol. Considerations for protocol optimization and results from Depletion (STED) technology in neurobiology. STED, developed primary cell cultures, stem cells, neuronal cells, and disease-relevant by Dr. Stefan Hell of the Max Planck Institute, in close cooperation cell types will be discussed. with Leica, takes fl uorescence microscopy below the diffraction limit to enable previously unobtainable images of the cellular interior with Part 2: Advances in Gene Expression and Protein Production resolution down to 90 nanometers. Technologies Leica has also expanded the resolution limits in large fi eld imaging Level: Intermediate for researchers imaging mice, Drosophila, zebrafi sh, and Arabidopsis. The Presenter: Henry Chiou Leica TCS LSI, the fi rst Macroscopic Confocal, will be discussed from a All areas of life science and drug development research depend on scientifi c and technological point of view. This system offers new levels robust and dependable protein expression systems. The ability to of resolution over the panorama required for imaging. achieve high protein yields with correct folding and post-translational modifi cations, while shortening processing time and lowering costs are Applied Biosystems 4:00 pm–5:00 pm, Room 201 requirements of many researchers. To meet these demands, Invitrogen Establishing and Characterizing Embryonic Stem Cell Lines continues to develop novel expression technologies. This seminar will Level: Intermediate discuss these technologies, including our cDNA3.3-TOPO® TA Presenter: Mike Irwin Cloning Kit for rapid cloning and remarkably high protein yields; Applied Biosystems lentiviral vectors that achieve enhanced gene delivery via greater virus 850 Lincoln Centre Drive titers and higher expression levels; the OptiCHO™ Express system for Foster City, CA 94404 development of stably integrated, gene amplifi ed CHO subclones to Phone: (650) 638-5041 express genes of interest; and the FreeStyle™ MAX Expression system Fax: (650) 638-5884 or rapid, high-level transient protein production in either CHO or www.appliedbiosystems.com HEK 293 cells.

Embryonic stem cell research is widely believed to hold tremendous potential for improving human health. Critical to this research is the identifi cation of molecular markers that can discriminate between embryonic stem cells in their pluripotent state and those that have changed or begun differentiation during stem cell passage or mainte- nance. Embryonic stem cells can also be examined for their miRNA profi le. Preamplifi cation technology coupled with specifi c real-time PCR TaqMan® Gene Expression and MicroRNA Assays in a low density array format now make it possible to look at single cell mRNA and miRNA profi les for the purpose of benchmarking these cells. Ap- plications of this technology will be presented. 97 MONDAY The American Society for Cell Biology 47th Annual Meeting

December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

EXHIBITOR SHOWCASES WASHINGTON CONVENTION CENTER

Applied Biosystems 5:00 pm–6:00 pm, Room 201 Roche Applied Science 6:15 pm–8:15 pm, Room 201 The SOLiD™ System: A Massively Parallel Sequencing System Enabling Technologies for Transfection and Real-Time Cellular Enabling Multiple Applications Analysis Level: Intermediate Level: Intermediate/Advanced Presenter: Robert Nutter Roche Applied Science Applied Biosystems 9115 Hague Road PO Box 50414 850 Lincoln Centre Drive Indianapolis, IN 46250-0414 Foster City, CA 94404 Phone: (800) 428-5433 Phone: (650) 638-5041 Fax: (317) 521-4396 Fax: (650) 638-5884 www.roche-applied-science.com www.appliedbiosystems.com The fi rst part of the program is made up of a series of real-world applica- The decreasing cost of sequencing is driving development of genome- tion presentations demonstrating the enabling results obtained utilizing wide applications based on sequence data. In place of different plat- FuGENE® HD Transfection Reagent. Strategies for optimization in forms for gene expression, genotyping and sequencing applications, applications such as viral production, protein expression, cell-based it’s becoming possible to use sequencing as the universal currency for HTS, and effective plasmid delivery in diffi cult-to-transfect cell lines genetic analysis. The SOLiD™ System is a ligation-based, massively will be highlighted. In addition to the effective transfection of cells, parallel sequencing system that generates up to 3Gb DNA sequence the ability to capture data from cellular assays in real time using a per run. Investigators can use either fragment or mate-paired libraries label-free technology offers signifi cant advantages in applications such and run one to multiple samples at a time. Collaborations with several as assay development, high content screening, functional monitoring scientifi c groups make use of the SOLiD™ System’s high throughput of receptor signaling and action, compound cytotoxicity profi ling, and system fl exibility to develop a range of applications including gene cell-mediated cytotoxicity, cell migration, and viral quantitation. A expression, ChIP analysis, whole genome sequencing, and targeted presentation of this enabling technology and illustrative results will resequencing. An update on application development and examples be the focus of the second part of the workshop. of the data generated will be presented. Media Cybernetics 8:30 pm–10:30 pm, Room 201 Arcxis Biotechnologies 6:15 pm–8:15 pm, Room 206 3D Image Acquisition, Processing, and Visualization For Optical Fully Automated Sample Preparation of Nucleic Acids Using the Lysix Microscopy Workstation™808 Level: Introductory Level: Introductory Presenters Name: Bartek Rajwa Presenter: J. Clark Mason Media Cybernetics Arcxis Biotechnologies 4340 East West Hwy 6920 Koll Center Parkway Suite 215 Bethesda, MD 20814 Pleasanton, CA 94566 Phone: (301) 495-3305 Phone: (925) 461-1300 Fax: (301) 495-5964 Fax: (925) 265-9000 http://www.mediacy.com www.arcxis.com Modern microscopy provides powerful tools for studying samples The Lysix Workstation™808 enables extremely rapid isolation (~10 varying from sub-cellular structures through cells to tissues. Effective min) of highly pure nucleic acids that are optimal for downstream use of these techniques requires in-depth knowledge about image ac- applications such as microarray analysis, real-time PCR, quantitative quisition, processing, and visualization. The goal of this workshop is to real-time PCR, and Northern blots, etc. It performs all the repetitive, demonstrate state-of-the-art hardware and software tools for collection, labor-intensive tasks associated with lysis, extraction, isolation, and processing, and visualization of multidimensional images. purifi cation of nucleic acids from cells, tissue, and blood, without the The workshop will address the following topics: Fundamentals of risk of experimental variances that are commonly encountered with electro-optical detection (CCD architecture, dynamic range, noise, alternative manual methods. At the core of the technology is a unique evaluating & selecting a CCD); 3-D image processing (limits of optical micro purifi cation card (Lysix MPC™) that will isolate and purify resolution, point-spread function, deconvolution algorithms); Visual- genomic DNA, total RNA or, mRNA. Cell lysis is done on the card at ization of multidimensional datasets (3-D reconstruction, surface and preprogrammed elevated temperatures (~90°C), increasing the effi cacy volume rendering, visualization of spectral and time-lapse images). of extraction and resulting in higher yields than would otherwise be The workshop is organized by Media Cybernetics, the producer of achievable at room temperature. Image-Pro Plus, and Qimaging, a manufacturer of high-performance digital cameras.

98 The American Society for Cell Biology 47th Annual Meeting MONDAY

December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

TUTORIALS WASHINGTON CONVENTION CENTER

Tutorial A Room 209A Tutorial C Room 203 High Affi nity Antibody Development, Conjugation & Applications Protein Dynamics Studied with Self-Labeling Protein Tags of Reagents for Total Cytotoxicity, Cell Proliferation, Cell Permeant Level: Introductory Apoptosis and Setting Up Multiplexed Immunological and Molecular Presenter: Andreas Brecht (Genotyping) Assays Covalys Biosciences AG Presenters: M. Olin, R. Vierling, and D. Moothart Benkenstrasse 41 American Qualex Antibodies/IQFCS/MCS Witterswil, CH-4108 920 Calle Negocio, Suite A Switzerland San Clemente, CA 92673 Phone: (011) 41-6172-52050 Phone: (949) 492-8298; Fax: (949) 492-6790 Fax: (011) 41-6172-52055 www.aqsp.com www.covalys.com

Several educational, problem-sharing and -solving technical presenta- The study of protein dynamics, especially the fate of the protein after tions will be given to help scientists advance research in immunology, biosynthesis inside living cells, is highly interesting, but also very dif- cell biology, and molecular biology. This Tutorial will include a variety fi cult to follow. In recent years new tools have become available that of methods, products, and services designed to assist in development allow selective and covalent labeling of a “time slice” of a protein. Bio- of assays using high affi nity monoclonal and polyclonal antibodies and chemical stability can be measured by loss of fl uorescence after a pulse conjugates. International Qualex Flow Cytometry Systems (IQFCS) of labeling. Timing of de novo protein biosynthesis, e.g., in relation to for total cytoxicity, cell proliferation, and apoptosis detection in vivo, the cell cycle, can be addressed by a nonfl uorescent blocker combined ex vivo, and in vitro will be presented. The presenters will also discuss with one fl uorescent label. Finally, sequential application of different Molecular Cytometry Systems (MCS) using MOL-PCR™ for mul- fl uorescent labels (pulse-chase) allows analysis of protein behavior after tiplex molecular (genotyping/SNP) assays. Interactive discussions will biosynthesis. This Tutorial will discuss one of the recently introduced be encouraged to assist scientists in choosing, developing, and utilizing self-labeling protein tags (SNAP-tag) as well report on studies from the proper tools for their specifi c research. If you are unable to attend Berkeley and San Diego. this workshop, please stop by booth #1115 or call (949) 492-8298 or visit www.aqsp.com (http://www.aqsp.com/). Tutorial D Room 208 Development and Application of Novel Photo-Switching/ Tutorial B Room 209B Photoactivatable and Sensory Proteins Studying Living Cells with Atomic Force Microscopy Level: Intermediate Level: Intermediate Presenter: Vsevolod Belousov Presenter: Sophia Hohlbauch Evrogen Asylum Research 6/10 Miklukho-Maklaya str. 6310 Hollister Avenue Moscow, 117997 Santa Barbara, CA 93117 Russia Phone: (805) 696-6466 Phone: (011) 7-495-4298020 Fax: (805) 696-6444 Fax: (011) 7-495-3307056 www.asylumresearch.com www.evrogen.com

This Tutorial will focus on studying living cells with atomic force Recently, considerable progress has been made in development of microscopy (AFM). This technique allows scientists to obtain 3D photoactivatable fl uorescent proteins (PAFPs). These proteins are topographic images of cells in culture without destroying them. The capable of a manyfold increase in fl uorescence intensity at certain ex- AFM probe can also be used to map proteins at the cell surfaces, and citation/emission wavelengths, in response to irradiation with specifi c to measure mechanical properties such as hardness of the membranes. light. This property can be used to “switch on” a fl uorescent signal and By combining AFM with optical techniques such as brightfi eld, epi- then track the movement of labeled cells, organelles, or individual fl uorescence, confocal, and TIRF, new types of data can be obtained. proteins. Variability of the spectral properties of PAFPs opens up new This Tutorial will provide numerous examples of data and guidelines possibilities in imaging that are not restricted to tracking labeled struc- on how to obtain such data. tures. Fluorescent proteins fused with specifi c protein domains allow scientists to visualize second messenger levels and enzymatic activities in the living cell. Such genetically encoded fl uorescent indicators have several advantages compared with chemical probes. This Tutorial will also discuss recent advances in development of FP-based indicators.

99 MONDAY The American Society for Cell Biology 47th Annual Meeting

December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

TUTORIALS WASHINGTON CONVENTION CENTER

Tutorial E Room 204B Tutorial G Room 204C Transfection 101: Mechanisms and Optimization Understanding and Performing DNA and siRNA Transfection with Level: Advanced Nonviral Vectors Presenter: Robert Brazas Level: Intermediate Mirus Bio Corporation Presenters: Patrick Erbacher and Jeanne-Francoise Williamson 505 South Rosa Road Polyplus-Transfection Inc. Madison, WI 53719 1251 Avenue of the Americas, 34th Floor Phone: (608) 441-2852 New York, NY 10020 Fax: (608) 441-2880 Phone: (508) 315-9629 www.mirusbio.com www.polyplus-transfection.com

Transfection, which is the delivery of foreign nucleic acids into mam- Transfection is widely used as a tool in research. It consists of introduc- malian cells, is an integral component of many research projects. ing nucleic acids into mammalian cells. If inadequate, transfection can Understanding the mechanism of transfection and practical methods become a limiting step for any project. Thus it is critical to understand to optimize transfection effi ciency are valuable tools for any researcher the mechanism of transfection to choose the most appropriate method. performing transfections. There are three goals of this presentation: This Tutorial will present the various transfection mechanisms as well as (1) introduce the various transfection methods and summarize the currently available methods and reagents for DNA and siRNA transfec- advantages and disadvantages of each method, (2) discuss current tion. The presenters will explain why some methods are more effective models of the mechanism of transfection, and (3) present important at transporting and releasing DNA and mRNA while others are better approaches to optimize transfection performance. Equipped with this for siRNA, and will describe the critical parameters for transfection critical information, the researcher will be better prepared to perform and their optimization. A solid understanding of transfection will allow optimal transfections that lead to successful experimental outcomes. scientists to obtain the best results in the shortest time frame.

Tutorial F Room 204A Tutorial H Room 209C Using NCBI’s Basic Local Alignment Search Tool: New Features and Optical and Atomic Force Microscopy: An Integrated Approach to Life Enhanced Interface Science Level: Intermediate Level: Intermediate Presenter: Peter Cooper Presenter: Andrea Slade National Center for Biotechnology Information Veeco Instruments Inc. National Library of Medicine 112 Robin Hill Road 8600 Rockville Pike Santa Barbara, CA 93117 Bethesda, MD 20894 Phone: (805) 967-2700 Phone: (301) 435-5951 Fax: (805) 967-7717 Fax: (301) 480-9241 www.veeco.com www.ncbi.nlm.nih.gov While atomic force microscopy (AFM) is capable of providing power- NCBI’s Web BLAST service is the most heavily used sequence simi- ful insights into the structural and kinetic aspects of molecular self- larity service worldwide, with over 300,000 searches per day. Recent assembly, it is inherently a “topographical” technique and therefore improvements include a redesigned, more intuitive BLAST homepage limited to characterizing the surface of a biomolecule. This, however, and submission forms, automatic adjustment of search parameters, does not always provide suffi cient information as to the biomolecular better options for creating subsets of databases, new statistics and fi lter structure-function relationship. Hence, the need arises for comple- options, new human and mouse transcript and genomic databases with mentary data that provide information about the molecular structure direct mapping of results onto the genome, and a separate tab for access or chemical state of a sample and that can be spatially correlated with to recent results and search strategies. This Tutorial will demonstrate the topographical features resolved by AFM. Optical microscopy is how to use the new features and interface to use BLAST more ef- ideal as a complementary tool to AFM. This Tutorial will describe fectively and effi ciently. Beginner, intermediate, and veteran users of several “multimodal” imaging platforms that have been developed by NCBI BLAST will be better able to use the power of the redesigned the integration of various optical techniques with AFM and will discuss NCBI BLAST after attending this Tutorial. their impact on the study of biological systems.

100 The American Society for Cell Biology 47th Annual Meeting MONDAY

December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

Poster Session 2 Halls A/B

Poster Set Up Sunday 6:00 pm–6:30 pm

Posters Displayed Sunday 7:00 pm–9:00 pm Monday 7:30 am–5:30 pm

Author Presentation Odd Boards 12:00 Noon–1:30 pm Even Boards 1:30 pm–3:00 pm

Poster Tear Down Monday 5:30 pm–6:00 pm

Board Numbers Session Titles Board Numbers Session Titles B1-8 Tight Junctions B331-349 New and Emerging Technologies for Cell Biology II B9-18 Cell Attachment to the Extracellular B350-356 Biological Computing and Modeling

Matrix B358-373 Tissue-specifi c Gene Expression B19-26 Metalloproteases B374-385 Chromatin Remodeling B27-44 Cell-Cell Interactions B386-399 Nuclear Envelope and Lamina B45-57 GAP Junctions B401-419 Synapse Formation and Function B58-77 Actin-associated Proteins I B421-440 Chloroplasts and Mitochondria B78-90 Cytoskeletal Oganization II B442-457 Signal Transduction in Development II B91-106 Unconventional Myosins I B459-468 Parasitology B107-128 Cilia and Flagella II B469-488 Host-Bacterial Pathogen Interactions B129-149 Cytoskeleton-Membrane Interactions I B489-511 Cancer II B150-174 Actin Dynamics and Assembly B512-532 Neuronal Diseases I B175-191 Cell Polarity B533-551 Other Diseases II B192-206 Development and Aging B552-559 Cell Motility – Techniques B207-214 Organogenesis B560-567 Cell Motility – Structural Basis B215-225 Protein Targeting B568-588 Centrosomes B226-249 Endocytic Machinery: Structure, B589-611 Microtubule Dynamics and Assembly Function and Regulation B612-632 Cell Motility – Regulation II B250-259 Exocytosis: Regulated Secretion B634-646 Kinetochores I B260-270 Membrane Channels B647-667 Mitosis and Meiosis II B271-290 Structure & Function of Membrane B668-684 Oncogenes and Tumor Supressors I Protein B685-694 Cell Cycle Stages B291-300 Protein Folding and Assembly B695-717 Signal Transduction II B302-328 Cell Culture B719-733 Extracellular Matrix and Cell Signaling I

Annual Meeting Poster Presentation Guidelines • Presenters should ensure their posters are placed on the appropriate poster board for the duration of their assigned poster sessions (the full 24-hour period). In cases of emergency, poster presenters who are unable to present should contact the ASCB at [email protected] to withdraw their abstract(s) before the Annual Meeting. In the case of withdrawn posters, a “WITHDRAWN” sign will be posted, along with the author’s contact information, on the poster board. • Poster presenters should stand at their poster locations during the appropriate 90-minute time slot—12:00 Noon–1:30 pm, or 1:30 pm–3:00 pm. (The specifi c information is included in the original poster notifi cation emails sent in September.) If presenters have to leave early, they should post a note on their boards stating when they will be available to answer attendee questions. • Cameras/Photography: Cameras and all other recording devices are strictly prohibited in all session rooms, on the Exhibit fl oor, and in all poster and oral presentation sessions.

101 MONDAY The American Society for Cell Biology 47th Annual Meeting

December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

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102 The American Society for Cell Biology 47th Annual Meeting MONDAY December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org

Washington, DC Convention Center, Halls A/B

Tight Junctions 873 B10 Intracellular Translocation and 881 B18 Regulation of TM4SF5-mediated Cytoskeletal Association of Syndecan-1 in Tumorigenesis through Induction of Cell Response to Mechanical Strain. A. Baker,1 A. Ji,1 Detachment and Death by Tiarellic Acid. S. 864 B1 Up-Regulation of ZO-1 by the E. Edelman1,2; 1Division of Health Sciences and Choi,1 S. Lee,2 K. Ahn,3 S. Oh,3 H. Lee,3 J. Lee4; Fibronectin-derived Peptide PHSRN in Cultured Technology, Massachusetts Institute of Technology, 1Department of Tumor Biology, Cancer Research Human Corneal Epithelial Cells. R. Yanai,1 J. Cambridge, MA, 2Cardiovascular Division, Brigham Institute, College of Medicine, Seoul National Ko,1 T. Chikama,2 T. Nishida1; 1Ophthalmology, and Women's Hospital, Boston, MA University, Seoul, Republic of Korea, 2Department Yamaguchi University Graduate School of of Molecular and Clinical Oncology, Cancer Medicine, Ube, Japan, 2Ocular Pathophysiology, ␣ 874 B11 Identification of - Research Institute, College of Medicine, Seoul Yamaguchi University Graduate School of ␣ Binding Sequences in the Laminin 2 Chain G National University, Seoul, Republic of Korea, Medicine, Ube, Japan 1 1 Domain. S. Urushibata, T. Yoshimura, N. 3Natural Medicine Research Center, Korea 1,2 1,2 1 Suzuki, K. Hozumi, Y. Kikkawa, N. Research Institute of Bioscience and 865 B2 Tight Junction Protein ZO-2 Travels 1 1 Motoyoshi ; Tokyo University of Pharmacy and Biotechnology, Daejeon, Republic of Korea, to the Nucleus before Reaching the Plasma 2 Life Sciences, Hachioji, Japan, NIDCR, National 4 Membrane. D. Chamorro, L. Alarcon, A. Ponce, L. Departments of Tumor Biology and Molecular and Institutes of Health, Bethesda, MD Gonzalez-Mariscal; Physiology, Biophysics and Clinical Oncology, Cancer Research Institute, Neuroscience, CINVESTAV, Mexico D.F., Mexico 875 B12 Peptide-Chitosan Membranes College of Medicine, Seoul National University, Promote Diverse Biological Functions. M. Seoul, Republic of Korea 866 B3 Reduciton of Claudin-2 by Nomizu, N. Yamagata, K. Hozumi, Y. Kikkawa; Nonsteroidal Anti-Inflammatory Drugs and Its Tokyo University of Pharmacy and Life Sciences, Contribution to Their Chemopreventive Effect. Metalloproteases Hachioji, Japan S. Mima, T. Mizushima; Faculty of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan 876 B13 Focal Adhesion Kinase (FAK): A 882 B19 Regulation of Adam 10-dependent Regulator of Cellular Mechanics. A. H. Klemm, P. APP Cleavage by TSPAN12, a Tetraspanin 867 B4 Renal Tubular Dysfunction in Protein. D. Xu,1,2 C. Sharma,1,2 M. Hemler1,2; 1 1 Kollmannsberger, D. Paranhos Zitterbart, C. Claudin-7 Deficient Mice. Y. Zhang, R. Tatum, 1Dana-Farber Cancer Institute, Boston, MA, 2 1 1 1 Raupach, B. Fabry, W. H. Goldmann; Medical K. Salleng, B. G. Jeansonne, Q. Lu, N. Luo, D. 2 Physics and Technology, University of Erlangen- Department of Pathology, Harvard Medical School, M. Terrian,1 J. J. Lin,3 Y. H. Chen1; 1Anatomy and Nuremberg, Erlangen, Germany Boston, MA Cell Biology, East Carolina University Brody School 2 of Medicine, Greenville, NC, Division of Animal 877 B14 The Prostate Transglutaminase 883 B20 Downregulation of Dickkopf-1 by Care, Vanderbilt University Medical Center, (TGase-4) Impacts the Cell-Matrix Adhesion of Three-Dimensional Culture Leads to Membrane 3 Nashville, TN, Department of Pediatrics, Section Prostate Cancer Cells: An Electric Cell- Type-1 Matrix Metalloproteinase Upregulation. 1 1 2 1 of Pediatric Nephrology and Hypertension, East Substrate Sensing Study. W. G. Jiang,1 R. J. M. Barbolina, L. Shea, M. Stack ; Chemical and Carolina University Brody School of Medicine, Ablin,2 H. Kynaston,1 M. D. Mason1; 1Metastasis & Biological Engineering, Northwestern University, 2 Greenville, NC Angiogenesis Research Group, Cardiff University Chicago, IL, Pathology & Anatomical Sciences, School of Medicine, Cardiff, United Kingdom, University of Missouri, Columbia, MO 868 B5 Occludin Variant 1B and Canonical 2Deptartment of Immunobiology, University of Occludin Could Accomplish Distinct Functions 884 B21 Recurrent Corneal Erosions in the Arizona College of Medicine and the Arizona in Epithelial and Endothelial Cells. Z. Muresan; Mouse Are Accompanied by Disrupted ␣6␤4 Cancer Center, Tucson, AZ Pharmacology and Physiology, UMDNJ–New Integrin and Elevated MMP-9 and ADAM-17/ Jersey Medical School, Newark, NJ 878 B15 Cell Adhesion Profiling for TACE. S. Pal-Ghosh, G. Tadvalkar, R. A. Jurjus, Y. Eukaryotic Cell Culture. V. Chu,1 J. J. Salisbury,2 Liu, M. A. Stepp; Anatomy and Cell Biology, 869 B6 WITHDRAWN N. Asbrock,1 R. Kovelman1; 1Stem Cell Biology, George Washington University, Washington, DC Millipore Corp, Temecula, CA, 2Cell Based Assays, 870 B7 The Tight Junction-associated 885 B22 Understanding the Biological Millipore Corporation, Temecula, CA RhoA Guanine Exchange Factor GEF-H1 Acts Significance of Tissue Inhibitor of as a TGF-beta Effector in Retinal Pigmented Metalloproteinase-2 (TIMP-2) Internalization and 1 879 B16 Fibroblast Collagen Receptor Epithelial Cell Transdifferentiation. A. Tsapara, Nuclear Translocation. R. Sivendran,1 Z. Xiao,2 T. 1 2 1 1 Spatial Distribution Links to Mechanical J. Greenwood, C. Hill, K. Matter, M. S. Balda ; 2 1 1 Deformation. S. C. Baxter,1 K. J. Langley,1 J. W. D. Veenstra, W. G. Stetler-Stevenson ; Cell and 1Institute of Ophthalmology, University College Stone,2 N. Kumar,3 M. Morales,3 C. T. Robinson,4 Cancer Biology Branch, National Cancer Institute, London, London, United Kingdom, 2London C. J. Murphy,2 E. C. Goldsmith3; 1Biomedical/ National Institutes of Health, Bethesda, MD, Research Institute, Cancer Research UK, London, 2 Mechanical Engineering, University of South Laboratory of Proteomics and Analytical United Kingdom Carolina, Columbia, SC, 2Chemistry and Technologies, Advanced Technology Program, 871 B8 Urinary Epidermal Growth Factor: Biochemistry, University of South Carolina, SAIC–Frederick, Inc., NCI–Frederick, Frederick, Plausible Physiological Regulator of Tight Columbia, SC, 3Cell and Developmental Biology MD and Anatomy, University of South Carolina, Junction Permeability along the Nephron. D. 886 B23 MMP14 Is Required for Directed 1 2 1 Columbia, SC, 4USC Nanocenter, University of Flores-Benitez, M. Franco, I. Larre, M. Cell Migration during Zebrafish Gastrulation. R. 1 1 1 South Carolina, Columbia, SC Cereijido, R. Contreras ; Fisiologia, CINVESTAV- Coyle, A. Latimer, J. Jessen; Medicine/Cancer IPN, D.F., Mexico, 2Nephrology, National Institute 880 B17 Probing the Early Stages of Bone Biology, Vanderbilt University Medical Center, of Cardiology Ignacio Chávez, D.F., Mexico Mineralization. Y. Meng,1 X. Ba,2 E. DiMasi,3 N. Nashville, TN Pernodet,2 M. Rafailovich,2 Y. Qin1; 1Biomedical 887 B24 MMP Cleavage of the Desmosomal Engineering, Stony Brook University, Stony Brook, Cell Attachment to the Extracellular Matrix Cadherins Contributes to Desmosome NY, 2Materials Science and Engineering, Stony Disassembly during TGF-beta-induced EMT. S. Brook University, Stony Brook, NY, 3National 872 B9 Reduced Migration, Altered Matrix, A. Keim,1 M. J. Wheelock,2 K. R. Johnson,2 J. K. Synchrotron Light Source, Brookhaven National and Enhanced TGF␤1 Signaling Are Signatures Wahl2; 1Genetics, Cell Biology and Anatomy, Laboratory, Upton, NY of Mouse Keratinocytes Lacking Syndecan-1. M. University of Nebraska Medical Center, Omaha, Stepp,1 Y. Liu,1 S. Pal-Ghosh,1 R. A. Jurjus,1 G. NE, 2Oral Biology, University of Nebraska Medical Tadvalkar,1 S. H. Yuspa2; 1Department of Anatomy Center, Omaha, NE and Cell Biology, The George Washington University Medical School, Washington, DC, 888 B25 NF-␬B Mediates Matrix 2Laboratory of Cancer Biology and Genetics, Metalloproteinase-induced EMT in Mammary National Cancer Institute, Bethesda, MD Epithelial Cells. J. A. Przybylo, A. E. Obr, D. C. Radisky; Cancer Biology, Mayo Clinic Jacksonville, Jacksonville, FL

103 MONDAY The American Society for Cell Biology 47th Annual Meeting Poster Session 2 B26–B52 December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org

889 B26 Apolactoferrin Inhibits the 898 B35 Plakophilin-1 Localization to the Gap Junctions Catalytic Domain of Matrix Metalloproteinase-2 Nucleus Is Specified by the Amino Terminal by a Zinc Chelation Mechanism. A. L. Newsome, Head Domain. J. K. Wahl; College of Dentistry 908 B45 Non-Healing Corneal Recovery J. P. Johnson, R. L. Seipelt, M. W. Thompson; Oral Biology, University of Nebraska Medical Triggered by Regulation of Direct Cell-Cell Biology, Middle Tennessee State University, Center, Lincoln, NE Communication. K. N. Chee,1 S. Ormonde,1 C. Murfreesboro, TN 2 2 1 899 B36 Delay Time of the Action Potential Petsoglou, L. Goold, C. N. J. McGhee, T. 1 1 1 in Two Cardiomyocytes Connected by Sherwin, C. R. Green ; Ophthalmology, University 2 Cell-Cell Interactions Fibroblasts. T. Kaneko,1,2 I. Suzuki,3 K. Ando,1 F. of Auckland, Auckland, New Zealand, Save Sight Nomura,1 T. Kitamura,3 J. Hayashi,1 K. Yasuda1; Institute, University of Sydney, Sydney, Australia 1Department of Biomedical Information, Institute of 890 B27 Investigating the Transport and 909 B46 Altered Permeability of Biomaterials and Bioengineering, Tokyo Medical Localization of the Cell Fusion Mediator Prm1. Connexin26 Non-Syndromic Deafness and Dental University, Tokyo, Japan, 2Precursory V. N. Olmo, E. Grote; Biochemistry and Molecular Associated Mutants. G. Mese,1 V. Valiunas,2 P. R. Research for Embryonic Science and Technology, Biology, Johns Hopkins University Bloomberg Brink,2 T. W. White2; 1Graduate Program in Japan Science and Technology Agency, Saitama, School of Public Health, Baltimore, MD Genetics, SUNY at Stony Brook, Stony Brook, NY, Japan, 3Department of Life Sciences, Graduate 2Department of Physiology and Biophysics, SUNY 891 B28 Knock Down of a Cardiac Myocyte School of Arts and Sciences, The University of at Stony Brook, Stony Brook, NY Intermediate Filament Protein, , Tokyo, Tokyo, Japan Disrupts Cell Adhesion. L. M. Lund, J. Lupinetti, 910 B47 Exposure to Dopamine and its D1 900 B37 Coordinate Suppression of Sdpr G. Vives-Rodriguez, M. Bond; Physiology, Receptor Antagonist SCH23390 Produces and Fhl1 Expression in Tumors of the Breast, University of Maryland, Baltimore, Baltimore, MD Large-Scale Ultrastructural Plasticity and Kidney, and Prostate. X. Li,1 Z. Jia,1 Y. Shen,1 H. Changes in Phosphorylation of Connexin36 in 892 B29 Compartmentalization of Signaling Ichikawa,2 J. Jarvik,3 R. G. Nagele,1 G. S. Neuronal Gap Junctions of Adult Rat Retina. J. Determines Kinetics of Granule Delivery by Goldberg1; 1UMDNJ, Stratford, NJ, 2National E. Rash,1 G. E. Pickard,1 K. G. V. Davidson,1 J. Cytotoxic T Lymphocytes and Effectiveness of Cancer Center Research Institute, Tokyo, Japan, O'Brien,2 A. T. E. Hartwick,1 N. Kamasawa,3 T. Target Cell Lysis. A. M. Beal,1 N. Anikeeva,1 R. 3Carnegie Mellon University, Pittsburgh, PA 1 J. I. Nagy4; 1Biomedical Sciences, Varma,2 T. O. Cameron,2 P. J. Norris,3 M. L. Yasumura, Colorado State University, Fort Collins, CO, Dustin,2 Y. Sykulev1; 1Thomas Jefferson University, 901 B38 The Cell Adhesion Protein HMR-1 2Opthalmology and Visual Science, University of Philadelphia, PA, 2Skirball Institute of Biomolecular Acts Together with CED-5/DOCK180 and with Texas Medical School at Houston, Houston, TX, Medicine, New York University School of Medicine, Two Rac Proteins to Initiate Gastrulation in C. 3Division of Cerebral Structure, National Institute of New York, NY, 3Blood Systems Research Institute elegans. G. Shemer, B. Goldstein; University of Physiological Sciences, Myodaiji, Okazaki, Japan, and the Departments of Laboratory Medicine and North Carolina–Chapel Hill, Chapel Hill, NC 4Physiology, University of Manitoba, Winnipeg, MB, Medicine, University of California, San Francisco, 902 B39 A Proteomic Analysis Reveals Canada San Francisco, CA New Roles for the Rho-GEF, Syx1 in Mediating 1 1 911 B48 Potential Interactions between 893 B30 Nanometer Membrane Cell-Cell Junctions. R. Geyer, H. Doeppler, M. 2 2 1 1 Connexin50 Intercellular Communication and Tubulovesicular Extensions (cytonemes) of Liu, A. Horowitz, P. Storz, P. Anastasiadis ; 1 2 Mitogen Activated Protein Kinase Signaling in Neutrophils: Formation, Functions, and Mayo Clinic, Jacksonville, FL, Dartmouth Medical Lens Growth. T. I. Shakespeare,1 C. Sellito,1 X. Degradation. S. I. Galkina,1 M. A. Pushkareva,1 J. School, Lebanon, NH Gong,2 T. W. White1; 1Physiology and Biophysics, M. Romanova,2 V. I. Stadnichuk,3 G. F. Sud'ina1; 903 B40 Teneurin-1 Is Expressed in Distinct 1A. N. Belozersky Institute of Physico-Chemical State University of New York, Stony Brook, Stony Regions of the Developing Brain and Is 2Optometry, University of California, Biology of Moscow State University, Moscow, Brook, NY, Processed In Vivo. D. Kenzelmann,1 R. P. Russian Federation, 2The Gamaleya Research Berkeley, CA Tucker,2 R. Chiquet-Ehrismann1; 1Growth Control, Institute of Epidemiology and Microbiology RAMS, Friedrich Miescher Institute, Basel, Switzerland, 912 B49 Mechanism of Cx26 Induced Moscow, Russian Federation, 3Department of 2School of Medicine, University of California at Increased Migration in Hela Cells. S. R. Physics, Moscow State University, Moscow, 1 2 1 Davis, Davis, CA Polusani, S. N. Zucker, B. J. Nicholson ; Russian Federation 1Biochemistry, University of Texas Health Science 904 B41 Use of Computer-assisted Drug 2Biological Sciences, 894 B31 The Role of Heterotypic Center, San Antonio, TX, Design Computational Tools to Identify Adhesions between Epithelial Cells and SUNY Buffalo, Buffalo, NY Potential Binding Sites of Protein D/E, a 32 Kd Fibroblasts in the Metastatic Cascade. M. Glycoprotein Involved in Sperm/Egg Membrane 913 B50 Are Connexins Required for Apostolopoulou, G. Quinones, D. Cao, L. Ligon; Fusion in Rats. D. Smith, J. C. Hall, P. N. Tosso; Convergence, Extension, and Cell Polarity Biology, Rensselaer Polytechnic Institute, Troy, NY 1 Chemistry/Center for Biotechnology, Norfolk State during Notochord Development? A. Krufka, J. Hatler,2 J. Reynhout,3 J. Sheridan,2 J. Essner,4 R. 895 B32 p120 Catenin Regulates Epithelial University, Norfolk, VA Johnson2; 1Department of Biological Sciences, Cell Growth. E. A. Perez,1 E. Soto,2 M. 905 B42 Analysis of Traction Forces Rowan University, Glassboro, NJ, 2Department of Yanagisawa,2 P. Z. Anastasiadis2; 1Hematology Exerted by Polarized Epithelial Cells in a Three- and Oncology, Mayo Clinic, Jacksonville, FL, Genetics, Cell Biology, and Development, dimensional Collagen Matrix. W. Shih, S. 2Cancer Biology, Mayo Clinic, Jacksonville, FL University of Minnesota, Minneapolis, MN, Yamada; Biomedical Engineering, University of 3Department of Biology, Bethel University, St. Paul, 896 B33 Effects of Corneal Epithelial Cells California, Davis, Davis, CA MN, 4Department of Genetics, Development and on the Expression of N-cadherin by Corneal Cell Biology, Iowa State University, Ames, IA 906 B43 RhoG Regulates Endothelial Fibroblasts in a Coculture System. J. Ko,1 R. Apical Cup Assembly Downstream from ICAM1 914 B51 Human Fibroblasts Responses to Yanai,1 T. Chikama,2 T. Nishida1; 1Ophthalmology, Engagement and Is Involved in Leukocyte Gap Junctional Intracellular Communication Yamaguchi University Graduate School of Transendothelial Migration. J. D. Van Buul; with Rat Mast Cells. T. T. Foley, H. P. Ehrlich; Medicine, Yamaguchi Ube, Japan, 2Ocular Molecular Cell Biology, University of Amsterdam, Plastic Surgery, Penn State Hershey Medical Pathophysiology, Yamaguchi University Graduate Amsterdam, The Netherlands School of Medicine, Yamaguchi Ube, Japan Center, Hershey, PA 907 B44 Disparate Effects of Different 897 B34 Biochemical, Molecular, and 915 B52 Involvement of Phosphorylation in Plakoglobin Mutations on Cell Mechanics. H. Functional Dissection of the Protein Complexes C-terminus in Regulation of rCx46 Connexons. Huang,1 A. Asimaki,2 D. Lo,3 W. McKenna,4 J. 1 A. Ngezahayo2; 1Hannover Medical That Regulate Spermatid Orientation during W. Walter, Saffitz2; 1Brigham and Women's Hospital, School, Molecular Cell Physiology, Hannover, Spermatogenesis in Adult Rat Testes. E. Wong,1 Cambridge, MA, 2Beth Israel Deaconess Medical 2 D. Mruk,1 W. Lee,2 C. Cheng1; 1Population Council, Germany, University Hannover, Institute of Center, Boston, MA, 3Invitrogen, London, United New York, NY, 2Department of Zoology, The Biophysics, Hannover, Germany Kingdom, 4University College London, London, University of Hong Kong, Hong Kong United Kingdom

104 The American Society for Cell Biology 47th Annual Meeting MONDAY December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org Poster Session 2 B53–B84

916 B53 Disulfide Bond Formation as a 927 B64 Enucleation of Cultured Mouse 937 B74 Septins Regulate Actin Control Point for Gap Junction Formation and Fetal Erythroblasts Requires Rac GTPases and Organization and Cell Cycle Arrest through Intercellular Communication. S. Das, T. Smith, J. mDia2. P. Ji, S. Jayapal, H. Lodish; Whitehead SOCS7-mediated Nuclear Accumulation of NCK. D. Ritzenthaler, M. Koval; Pulmonary Medicine, Institute for Biomedical Research, Cambridge, MA B. E. Kremer,1,2 L. A. Adang,1 I. G. Macara1,2; Emory University, Atlanta, GA 1Department of Microbiology, University of Virginia, 928 B65 Nascent Peptide Mediated Charlottesville, VA, 2Center for Cell Signaling, 917 B54 Cell-Cell Communication in P2Y2 Perinuclear Localization of Dia1 mRNA in University of Virginia, Charlottesville, VA KO Tenocytes Is Impaired Due to Faulty Cx43 Fibroblasts. G. Liao, X. Ma, N. N. Okuhama, G. Trafficking. M. Tsuzaki,1 A. Fox,2 J. Qi,1,2 M. E. Liu; Cell Biology & Cancer Research, Albany 938 B75 A Novel Amoeba proteus 120-kDa Wall,1 J. Wang,1 R. Sumanasinghe,1 A. J. Medical College, Albany, NY Actin-binding Protein. J. M. Redowicz,1 M. Banes1,2; 1Flexcell International Corporation, Sobczak,1 E. Kocik,1 Y. Rhrzepetskiy,2 J. Jozwiak1; Hillsborough, NC, 2Biomedical Engineering, North 929 B66 The C. elegans Cytokinesis 1Department of Biochemistry, Nencki Institute of Carolina State University/University of North Formin Cyk1 Differentially Utilizes Three Profilin Experimental Biology, Warsaw, Poland, 2Institute of Carolina, Raleigh and Chapel Hill, NC Isoforms to Rapidly Assemble Actin Filaments. Cell Biology, NANU, Lvov, Ukraine D. R. Kovar, E. M. Neidt, C. C. Yeykal; The 918 B55 Luteinizing Hormone Decreases University of Chicago, Chicago, IL 939 B76 Head/-tail Interaction of Vinculin the Permeability of Somatic Cell Gap Junctions Influences Mechanical Behavior in Cells. G. in the Mouse Ovarian Follicle, Prior to Nuclear 930 B67 Ezrin Has a Unique Role in Diez, C. T. Mierke, J. Smith, W. H. Goldmann; 1 Envelope Breakdown. R. P. Norris,1 M. Lymphoid Development. M. H. Shaffer, M. Medical Physics and Technology, University of 1 1,2 3 4 Freudzon,1 A. Cowan,2 L. M. Mehlmann,1 D. Paul,3 Velez, J. K. Choi, I. Saotome, A. Sperling, A. Erlangen-Nuremberg, Erlangen, Germany 1 3 1,2 L. A. Jaffe1; 1Department of Cell Biology, University Bhandoola, A. I. McClatchey, J. K. Burkhardt ; 1 of Connecticut Health Center, Farmington, CT, Department of Pathology and Lab Medicine, 940 B77 The Role of Myosin II and Myosin 2Center for Cell Analysis and Modeling, University University of Pennsylvania School of Medicine, Light Chain Kinase in ERK Signaling in Human 2 of Connecticut Health Center, Farmington, CT, Philadelphia, PA, Childrens Hospital of Ras Transformed Epithelial Cells. P. Khan, X. 3 3Department of Neurobiology, Harvard Medical Philadelphia, Philadelphia, PA, Department of Liu, D. M. Helfman; Cell Biology and Anatomy, School, Boston, MA Pathology, MGH Cancer Center and Harvard University of Miami Miller School of Medicine, Medical School, Boston, MA, 4Department of Miami, FL 919 B56 Inhibition of Gap Junction Medicine, University of Chicago Medical School, Intercellular Communication in Response to Chicago, IL Activation of G-protein Coupled Receptors Is Cytoskeletal Organization II Mediated via Gap Junction Internalization. S. M. 931 B68 Cloning and Analysis of Zebrafish 1 Baker, M. M. Falk; Department of Biological (Danio rerio) Supervillin. S. Duleh, R. W. 941 B78 Interphase Microtubules Arrays in 2 2 2 Sciences, Lehigh University, Bethlehem, PA Bauernfeind, A. Cohen, R. K. Pope ; Fission Yeast Mutants Studied by Electron 1Department of Molecular & Cell Biology, University Tomography. H. D. Roque,1 D. N. Mastronarde,2 920 B57 Function of Clathrin and of California, Berkeley, Berkeley, CA, 2Department J. R. McIntosh,2 D. Brunner,1 C. Antony1; 1Cell Accessory Proteins in Gap Junction of Biological Sciences, Indiana University South Biology and Biophysics, EMBL, Heidelberg, Internalization. A. Gumpert, M. M. Falk; Biological Bend, South Bend, IN Germany, 2The Boulder Laboratory for 3D EM of Sciences, Lehigh University, Bethlehem, PA Cells, Boulder, CO 932 B69 Expression of the Human T-plastin in Dictyostelium discoideum. M. D. Camargo, A. 942 B79 Shroom Family Proteins Regulate Actin-associated Proteins I G. Maselli; Biological Sciences, Chicago State Gamma-Tubulin Distribution and Microtubule University, Chicago, IL Architecture during Epithelial Cell Shape 921 B58 Three Tissue-specific Twinfilin Change. C. Lee, J. B. Wallingford; Molecular Cell 933 B70 Binding of CARMIL to Actin Isoforms Are Expressed in Mammals. E. M. and Developmental Biology, The University of Capping Protein. S. Ghosh, D. Sept; Biomedical Nevalainen,1 H. Wang,2 M. Moser,2 R. Faessler,2 P. Texas at Austin, Austin, TX Engineering, Washington University, St. Louis, MO Lappalainen1; 1Institute of Biotechnology, Helsinki, 2 943 B80 Interphase Microtubules Position Finland, Max Planck Institute for Biochemistry, 934 B71 Over Expression of Dictyostelium and Align Nascent Mitotic Spindles. S. K. Vogel, Martinsried, Germany CARMIL Induces the Formation of Filopodia I. Raabe, I. Tolic-Norrelykke; MPI-CBG, Dresden, Independently of Its Anti-Capping Protein 922 B59 Investigating ADF/Cofilin Activity Germany Activities. G. Jung, J. A. Hammer; Laboratory of in Toxoplasma gondii and Its Role in Gliding Cell Biology, NIH, Bethesda, MD Motility. S. Mehta, L. D. Sibley; Molecular 944 B81 Assembling Artificial Mitotic Spindles In Vitro Using Dielectrophoresis and Microbiology, Washington University School of 935 B72 Material Properties and Failure of Microscale Kinesin Patterning. M. Uppalapati,1 Y. Medicine, St. Louis, MO Filamin A Cross-linked Actin Networks. K. E. Huang,2 T. N. Jackson,2 W. O. Hancock1; Kasza,1 G. H. Koenderink,2 Y. Lin,1 F. Nakamura,3 923 B60 Tropomyosin 1 Modulates Cofilin 1Bioengineering, Pennsylvania State University, T. P. Stossel,3 F. C. MacKintosh,4 D. A. Weitz1; Activity in Kidney Proximal Tubule Cells. S. L. University Park, PA, 2Electrical Engineering, 1School of Engineering and Applied Sciences and Ashworth,1,2 S. E. Wean,2 M. A. Hallett,2 B. A. Pennsylvania State University, University Park, PA Department of Physics, Harvard University, Molitoris2; 1Biochemistry, Molecular Biology and Cambridge, MA, 2AMOLF FOM, Amsterdam, The Microbiology, University of Maine, Orono, ME, 945 B82 Characterization of INF1, a Novel Netherlands, 3Hematology Division, Brigham and 2Medicine, Indiana University, Indianapolis, IN Microtubule-associated Formin Protein. K. Women's Hospital, Department of Medicine, Young,1 S. Copeland,1 R. Kothary,2,1 J. Copeland1; 924 B61 Regulation of Cofilin-Phosphatase Harvard Medical School, Boston, MA, 4Department 1Cellular and Molecular Medicine, University of Activity of Slingshot-1 by Par-1/MARK3. T. of Physics and Astronomy, Vrije Universiteit, Ottawa, Ottawa, ON, Canada, 2Molecular Medicine Mishima, Y. Ohta, K. Ohashi, K. Mizuno; Graduate Amsterdam, The Netherlands Program, Ottawa Health Research Institute, School of Life Science, Tohoku University, Sendai, Ottawa, ON, Canada 936 B73 High Molecular Weight Japan Tropomyosins Maintain the Proliferative 946 B83 The Initiation, Construction, and 925 B62 Yeast Cofilin Severs Tropomyosin Capacity of Normal Cells. G. Schevzov,1 N. S. Maturation of the Basal Complex in Toxoplasma Decorated Actin Filaments. X. Fan, R. Li; Bryce,1 T. Fath,1 P. L. Jeffrey,2 R. P. Weinberger,1 gondii. K. Hu; Biology, Indiana University, Stowers Institute for Medical Research, Kansas P. W. Gunning1; 1Oncology Research Unit, The Bloomington, Bloomington, IN City, MO Children's Hospital at Westmead, Sydney, Australia, 2Developmental Neurobiology Unit, The 947 B84 Forchlorfenuron: A Small Molecule 926 B63 The Cell Wall Integrity Pathway Children's Medical Research Institute, Sydney, Inhibitor of Mammalian Septin Organization and Promotes the Proteolysis of the Formin Bni1 Australia Function. Q. Hu, E. T. Spiliotis, W. J. Nelson; after Heat-Shock. K. Kono, B. Atkins, D. Pellman; Biological Sciences, Stanford University, Stanford, Pediatric Oncology, Dana-Farber Cancer Institute, CA Harvard Medical School, Boston, MA

105 MONDAY The American Society for Cell Biology 47th Annual Meeting Poster Session 2 B85–B114 December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org

948 B85 Proteomic Analysis of the Ciliate 958 B95 Myosin XVa Is Critical for 967 B104 The Yeast Class V Myosin, Membrane Skeleton. H. Said,1 E. Zbornik,1 J. E. Structural Development but Not Myo2p, Is Associated with Large, mRNA- Honts,1 D. Dassenko,2 K. Friede,2 D. Beussman2; Mechanosensory Function of Hair Cell containing Complexes Including the RNA 1Biology, Drake University, Des Moines, IA, Stereocilia. R. Stepanyan,1 I. A. Belyantseva,2 A. Processing (P) Body. W. Chang,1,2 R. F. 2Chemistry, St. Olaf College, Northfield, MN J. Griffith,3 T. B. Friedman,2 G. I. Frolenkov1; Zaarour,1,2 S. Reck-Peterson,1 J. Rinn,1 R. Singer,3 1Department of Physiology, University of Kentucky, M. Snyder,1 P. Novick,2 M. S. Mooseker1,2; 949 B86 Dimerization of Villin Is Required Lexington, KY, 2Laboratory of Molecular Genetics, 1Department of Molecular, Cellular & for Its Apical Localization. S. P. George, M. R. NIDCD/NIH, Rockville, MD, 3Otolaryngology Developmental Biology, Yale University, New Siddiqui, S. Khurana; Department of Physiology, Branch, NIDCD/NIH, Rockville, MD Haven, CT, 2Department of Cell Biology, Yale University of Tennessee, Memphis, TN University School of Medicine, New Haven, CT, 959 B96 Talin Influences the Dynamics of 3 950 B87 Fluid Sheer Stress Induces Anatomy and Structural Biology, Albert Einstein the Myosin VII-Membrane Interaction. S. A. College of Medicine, Bronx, NY Changes in Endothelial Stress Kinase Activity Galdeen,1 S. Stephens,1 D. D. Thomas,2 M. A. 1 2 and Location. M. Mengistu, S. Ghadiali, D. Ou- Titus1; 1Genetics, Cell Biology & Development, 968 B105 Characterization of the 3 1 1 Yang, L. Lowe-Krentz ; Biological Sciences, University of Minnesota, Minneapolis, MN, Mechanism of Ash1 mRNA Transport by Myo4p. 2 Lehigh University, Bethlehem, PA, Mechanical 2Biochemistry, Molecular Biology & Biophysics, L. M. Bond,1 J. R. Sellers,1 K. Bloom,2 T. Engineering and Mechanics, Lehigh University, University of Minnesota, Minneapolis, MN Sakamoto1; 1NHLBI, National Institutes of Health, 3 Bethlehem, PA, Physics, Lehigh University, Bethesda, MD, 2Biology, University of North Bethlehem, PA 960 B97 Tail-dependent Regulation of Carolina at Chapel Hill, Chapel Hill, NC Drosophila Myosin 7a. Y. Yang,1 M. Chen,1 T. 951 B88 Characterization of Molecular Baboolal,2 M. Walker,2 M. Peckham,2 P. J. Knight,2 969 B106 Drosophila Myosin V. A. Hong,1 J. Events in Spermiation: Role of Sertoli Cell J. R. Sellers1; 1Laboratory of Molecular Physiology, Toth,2 J. R. Sellers1; 1Laboratory of Molecular Cytokeleton. R. S. D'Souza, S. Sonawane, N. National Heart, Lung and Blood Institute, Bethesda, Physiology, NHLBI, NIH, Bethesda, MD, Balasinor; Neuroendocrinology Division, National MD, 2University of Leeds, Leeds, United Kingdom 2Laboratory of Genome Metabolism and Repair, Institute for Research in Reproductive Health, Institute of Enzymology, Hungarian Academy of Mumbai, India 961 B98 Structural Basis for the Regulation Sciences, Budapest, Hungary of Drosophila Myosin 7a. T. G. Baboolal,1 Y. 952 B89 Modulation of the Cytoskeleton of Yang,2 M. L. Walker,1 J. R. Sellers,2 P. J. Knight,1 Osteoblasts in Microgravity Environments. N. M. Peckham1; 1University of Leeds, Leeds, United Cilia and Flagella II 1 2 1 Nabavi, R. Harrison ; Cell and Systems Biology, Kingdom, 2National Institutes of Health, Bethesda, University of Toronto, Toronto, ON, Canada, MD 970 B107 A Proteomics Approach Identifies 2Biological Sciences, University of Toronto, Toronto, Novel Tetrahymena Basal Body Components. C. ON, Canada 962 B99 Increased Trafficking of Zipcode L. Kilburn, M. Winey; Molecular, Cellular, and Binding Protein in Neuronal Processes by Developmental Biology, University of Colorado, 953 B90 Myoblasts and Macrophages Perturbation of Myosin Va and Dynein. V. C. Boulder, Boulder, CO Share Molecular Components That Contribute Nalavadi,1 L. E. Griffin,1 A. M. Swanson,1 T. to Cell-Cell Fusion. K. Pajcini; Baxter 2 1 1 1 Takumi, Y. Sasaki, G. J. Bassell ; Cell Biology, 971 B108 Identification and Laboratories, Stanford University School of Emory University School of Medicine, Atlanta, GA, Characterization of Basal Body Cartwheel Medicine, Stanford, CA 2 Suita, Osaka Bioscience Institute, Osaka, Japan Proteins. C. G. Pearson, M. Winey; Molecular, Cellular, and Developmental Biology, University of 963 B100 Dynamics of Myosin 5c Colorado, Boulder, Boulder, CO Unconventional Myosins I Associated Membrane Compartments in Human Cells. D. Jacobs, R. Cheney; Cell and Molecular 972 B109 The Uni2 Protein Is a Cell-Cycle 954 B91 The Motor Activity of Myosin-X Physiology, University of North Carolina–Chapel Regulated Marker of Basal Bodies in Promotes Actin Fiber Convergence at the Cell Hill, Chapel Hill, NC Chlamydomonas reinhardtii. B. P. Piasecki, C. D. Periphery to Initiate Filopodia Formation. H. Silflow; Department of Plant Biology, University of 1 2 1 1 964 B101 A Novel Myosin V Interacting Tokuo, K. Mabuchi, M. Ikebe ; Physiology, Minnesota, St. Paul, MN University of Massachusetts Medical School, Protein That Is Involved in Rac Signaling and Worcester, MA, 2Muscle Research Group, Boston Regulates Neurite Outgrowth. M. Lisé,1 D. 973 B110 Read-through Mutation of LC8 Biomedical Research Institute, Watertown, MA Srivastava,2 V. Viswanathan,1 J. A. Mercer,3 P. Results in Differential Defect in Axonemal Penzes,2 A. El-Husseini1; 1Psychiatry, University of Complexes. C. Yang, P. Yang; Biology, Marquette 955 B92 Myosin-10 Functions to Anchor British Columbia, Brain Research Centre, University, Miwaukee, WI the Mitotic Spindle and Maintain Spindle Vancouver, BC, Canada, 2Physiology, Northwestern Integrity. S. Woolner,1 L. O'Brien,2 C. Wiese,2 W. University, Feinberg School of Medicine, Chicago, 974 B111 Analysis of the Flagellar Tip of M. Bement1; 1Zoology, University of IL, 3McLaughlin Research Institute, Great Falls, MT Chlamydomonas reinhardtii by Difference Gel Wisconsin–Madison, Madison, WI, 2Biochemistry, Electrophoresis (DIGE). R. D. Sloboda; Biological University of Wisconsin–Madison, Madison, WI 965 B102 Human Myosin Vc Is a Low Duty Sciences, Dartmouth College, Hanover, NH Ratio, Non-Processive Molecular Motor. Y. 956 B93 Intrafilopodial Motility of Myosin-X Takagi,1 Y. Yang,1 M. Kovács,2 I. Fujiwara,3 D. 975 B112 The Axonemal Kinase CK1 and Its Candidate Cargos. M. M. DiVito,1 M. L. Jacobs,4 R. E. Cheney,4 J. R. Sellers1; 1Laboratory Interacts with Tubulin and Regulates Dynein- Kerber,1 A. D. Stephens,1 D. T. Jacobs,1 A. B. of Molecular Physiology, NIH, Bethesda, MD, driven Microtubule Sliding in Chlamydomonas Bohil,2 R. E. Cheney1; 1Cell and Molecular 2Department of Biochemistry, Eötvös University, Flagella. A. Gokhale, M. Wirschell, W. Sale; Cell Physiology, University of North Carolina at Chapel Budapest, Hungary, 3Laboratory of Cell Biology, Biology, Emory University, Atlanta, GA Hill, Chapel Hill, NC, 2Cellular and Molecular NIH, Bethesda, MD, 4Cell and Molecular Pharmacology, University of California at San Physiology, University of North Carolina–Chapel 976 B113 A B-subunit of the Phosphatase Francisco, San Francisco, CA Hill, Chapel Hill, NC PP2A Is Localized to the Flagellar Axoneme in Chlamydomonas. C. A. Elam, L. A. Fox, M. 957 B94 Myosin 19 (Myo19) Is a Novel 966 B103 Extensibility of Coiled-Coil Wirshcell, W. S. Sale; Cell Biology, Emory Unconventional Myosin Involved in Regions of Processive and Nonprocessive University, Atlanta, GA Mitochondrial Motility. O. A. Quintero,1,2,3 K. M. Myosin V Molecules. A. Nagy, J. Sellers; LMP, Denehy,2 M. B. Kortan,2 L. B. Case,2 A. J. Lier,2 N. NIH/NHLBI, Bethesda, MD 977 B114 Characterization of an Axonemal Panaretos,2 M. M. Demczko,2 J. L. Walck,2 Q. cGMP-dependent Protein Kinase (PKG) in Slater,1 R. E. Cheney3; 1Department of Biological Chlamydomonas reinhardtii. J. Belen-Rivera, B. Sciences, Mount Holyoke College, South Hadley, Verhalen, A. D. Solmonson, A. R. Gaillard; MA, 2Department of Biology, Franklin and Marshall Biological Sciences, Sam Houston State University, College, Lancaster, PA, 3Department of Cell and Huntsville, TX Molecular Physiology, University of North Carolina–Chapel Hill, Chapel Hill, NC

106 The American Society for Cell Biology 47th Annual Meeting MONDAY December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org Poster Session 2 B115–B145

978 B115 Conformational Changes of 988 B125 Outer Row Dynein Assembly 997 B134 Paxillin-Kinase-Linker (PKL) Dynein Arms In Situ Studied Using X-Ray Requires IFT and ODA16p as an IFT Adaptor. C. Tyrosine Phosphorylation in Regulation of Diffractions of Chlamydomonas Flagellar Gao,1 N. Ahmed,1 D. G. Cole,2 D. R. Mitchell1; Growth Factor-dependent Cell Morphology and Axonemes. K. Oiwa,1,2 S. Toba,1 H. Sakakibara,1 1Cell & Developmental Biology, SUNY–Upstate Migration. J. A. Yu, C. E. Turner; Cell & H. Iwamoto3; 1Kobe Advanced ICT Research Medical University, Syracuse, NY, 2University of Developmental Biology, SUNY Upstate Medical Center, Kobe, Japan, 2Graduate School of Life Idaho, Moscow, ID University, Syracuse, NY Science, University of Hyogo, Hyogo, Japan, 3Japan Synchrotron Radiation Research Institute, 989 B126 Remodeling of Anterograde IFT 998 B135 Adducin Promotes Micron-Scale SPring-8, Harima, Japan Complexes in Chlamydomonas fla10.1 and the Organization of the Lateral Membrane in Role of IFT in Flagellar Disassembly. W. Dentler, Epithelial Cells. K. M. Abdi, V. Bennett; Cell 979 B116 The Heterodimeric Axonemal K. McCommis; Molecular Biosciences, University of Biology, Duke University, Durham, NC Dynein f: Its Mechanical and Enzymatic Kansas, Lawrence, KS Properties and Possible Roles in Beating of 999 B136 Spatial Organisation of E- Flagellar Axoneme. N. Kotani,1 S. Toba,2 H. 990 B127 The Dynamics and Function of cadherin Adhesion Foci by the Actin Kojima,2 K. Oiwa,2 H. Sakakibara2; 1Graduate Flagellar PKD2 in Chlamydomonas: Processing Cytoskeleton in Drosophila Embryonic 1 1 2 School of Life Science, University of Hyogo, of PKD2 and Its Function in Mating. K. Huang, Epithelial Cells. M. Cavey, P. F. Lenne, T. 1 1 2 1 1 2 Harima Science Park City, Hyogo, Japan, 2Kobe D. R. Diener, A. Mitchell, G. J. Pazour, G. B. Lecuit ; IBDML, Marseille, France, Institut 3 1 1 Advanced ICT Research Center, National Institute Witman, J. L. Rosenbaum ; MCDB, Yale Fresnel, Marseille, France 2 of Information and Communications Technology, University, New Haven, CT, Program in Molecular Medicine, University of Massachusetts Medical 1000 B137 Forced Unfolding of Proteins Kobe, Japan 1 School, Worcester, MA, 3Department of Cell within Cells: A Proteomic Method. C. Carag, C. 1 2 2 1 980 B117 ADP Increases the Switching Biology, University of Massachusetts Medical Johnson, H. Tang, D. Speicher, D. E. Discher ; 1 Threshold of the Bull Sperm Beat, an Effect School, Worcester, MA Chemical and Biomolecular Engineering, 2 That Can Be Explained by Increased University of Pennsylvania, Philadelphia, PA, The Microtubule Binding Affinity of Dynein. K. A. 991 B128 Chlamydomonas FAP133 Is a Wistar Institute, Philadelphia, PA Dynein Intermediate Chain Associated with the Lesich, D. W. Pelle, C. B. Lindemann; Biological 1001 B138 Testing the Role of Spectrin in Sciences, Oakland University, Rochester, MI Retrograde Intraflagellar Transport Motor. P. Rompolas,1 L. B. Pedersen,2 R. S. Patel-King,1 S. Plasma Membrane Protein Presentation: A 981 B118 Analysis of Force Generation M. King1; 1Department of Molecular Microbial & Proteomic Approach. M. R. Khanna, G. H. Patterns during C. reinhardtii Flagella Structural Biology, University of Connecticut Health Thomas; Biology and BMB, Penn State University, Regeneration. C. Clodfelter,1 M. Shaban,1 J. Center, Farmington, CT, 2Department of Molecular University Park, PA Yukich,2 K. Bernd3; 1Center for Interdisciplinary Biology, University of Copenhagen, Copenhagen, 1002 B139 Alternative Promoter Usage and Studies, Davidson College, Davidson, NC, Denmark Alternative Splicing Produce Novel Ankyrin-G 2Physics, Davidson College, Davidson, NC, Variants in Mouse Kidney. J. Li, X. Su, P. R. 3Biology, Davidson College, Davidson, NC Cytoskeleton-Membrane Interactions I Smith; Physiology & Biophysics, University of Alabama at Birmingham, Birmingham, AL 982 B119 A Novel Role for PIP2 in Flagellar Axoneme Assembly. H. Wei,1 L. Fabian,1 J. 992 B129 The Sterile Gene Collection: 1003 B140 Interaction between Ankyrin-G Rollins,2 G. Polevoy,1 C. Bazinet,2 J. A. Brill1; Filling the Gap in Functional Genomic Analysis and H+,K+-ATPase ␣2 in Renal Epithelia. J. Li, 1Developmental and Stem Cell Biology, Hospital for of Cell Biological Processes in C. elegans. R. A. X. Su, P. R. Smith; Physiology & Biophysics, Sick Children, Toronto, ON, Canada, 2Biology, St. Green, A. Audhya, A. Desai, K. Oegema; Cellular University of Alabama at Birmingham, Birmingham, John's University, Jamaica, NY and Molecular Medicine, Ludwig Institute for AL Cancer Research, University of California, San 983 B120 Mathematical Models of the Diego, La Jolla, CA 1004 B141 Small Ankyrin 1 Organizes the Flagellar Length Control System in Network Compartment of the Sarcoplasmic Chlamydomonas reinhardtii. W. B. Ludington, W. 993 B130 Novel Interactions of the Reticulum Around the Contractile Apparatus of F. Marshall; Biochemistry and Biophysics, Dystonin Protein. K. Bhanot, K. Young, R. Atriated Muscle. M. A. Borzok, A. Kontrogianni- University of California, San Francisco, San Kothary; Department of Cellular and Molecular Konstantopoulos, W. R. Randall, R. J. Bloch; Francisco, CA Medicine, Ottawa Health Research Institute, University of Maryland, Baltimore, MD University of Ottawa, Ottawa, ON, Canada 984 B121 Flagellar Length Control: Key 1005 B142 Type I␤ Phosphatidylinositol-4- Insights from Short Flagella Mutants. E. S. 994 B131 Supervillin Slows Cell Spreading phosphate 5-kinase Promotes Focal Adhesion Kannegaard, J. L. Feldman, W. F. Marshall; by Facilitating Myosin II Contraction at the Cell Disassembly. W. T. Chao, A. C. Daquinag, J. University of California, San Francisco, San 1,2 3,2 3,2 Periphery. N. Takizawa, R. Ikebe, M. Ikebe, Kunz; Molecular Physiology and Biophysics, Baylor Francisco, CA 1,2 1 E. J. Luna ; Cell Biology, University of College of Medicine, Houston, TX Massachusetts Medical School, Worcester, MA, 985 B122 Studying Dynamics of Flagellar 2Cell Dynamics Program, University of 1006 B143 Supervillin: A Membrane Length. K. A. Wemmer, J. L. Feldman, W. F. Massachusetts Medical School, Worcester, MA, Skeleton Protein at Podosomes and Marshall; Biochemistry, University of California, San 3Physiology, University of Massachusetts Medical Invadopodia. J. L. Crowley, E. J. Luna; Francisco, San Francisco, CA School, Worcester, MA Department of Cell Biology, Program in Cell 986 B123 IFT Raft Size Scales Inversely Dynamics, University of Massachusetts Medical 995 B132 Src Utilizes Robo1 to Promote with Flagellar Length. B. D. Engel, W. F. School, Worcester, MA Tumor Cell Migration. P. R. Khusial, G. Goldberg; Marshall; University of California, San Francisco, Molecular Biology, UMDNJ, Voorhees, NJ 1007 B144 Supervillin Associations with San Francisco, CA Trafficking Membranes. T. C. Smith, Z. Fang, J. 996 B133 Myosin II-dependent Regulation 987 B124 Electron Tomographic Analysis L. Crowley, N. Takizawa, E. J. Luna; Department of of Dendritic Cell Migration by the MHC Class II- of Intraflagellar Transport Complexes In Situ. G. Cell Biology, Program in Cell Dynamics, University associated Invariant Chain. G. Faure-Andre,1 P. Pigino,1 S. Geimer,2 S. Lanzavecchia,3 E. of Massachusetts Medical School, Worcester, MA Vargas,1 J. Manry,1 J. Diaz,1 M. Yuseff,1 M. Paccagnini,1 F. Cantele,3 J. L. Rosenbaum,4 P. Rosemblatt,2 M. Piel,3 A. Lennon-Dumenil1; 1008 B145 The Actin-regulatory Protein Lupetti1; 1Department of Evolutionary Biology, 1Inserm U653, Institut Curie, Paris, France, HS1 Is Required for Efficient Antigen University of Siena, Siena, Italy, 2Biologie/ 2Facultad de Ciencias, Universidad de Chile, Processing by Dendritic Cells. C. Biswas,1 Y. Elektronenmikroskopie, Universität Bayreuth, Santiago, Chile, 3CNRS UMR144, Institut Curie, Huang,1 D. A. Klos,1 E. O. Comiskey,1 S. Gallucci,2 Bayreuth, Germany, 3Department of Structural Paris, France Y. Argon,1 J. K. Burkhardt1; 1Department of Chemistry, University of Milano, Milano, Italy, Pathology and Lab Medicine, Children's Hospital of 4Department of Molecular, Cellular and Philadelphia and the University of Pennsylvania, Developmental Biology, Yale University, New Philadelphia, PA, 2Department of Pediatrics, Haven, CT Children's Hospital of Philadelphia and the University of Pennsylvania, Philadelphia, PA

107 MONDAY The American Society for Cell Biology 47th Annual Meeting Poster Session 2 B146–B175 December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org

1009 B146 ATP-binding Cassette Protein 1017 B154 Actin-Filament Stochastic 1027 B164 Src-mediated Phosphorylation A1 (ABCA1) Influences Actin Organization and Dynamics Mediated by ADF/Cofilin and Capping of Cortactin Regulates Aberrant Actin Cell Adhesion. Y. Feng, Y. Yao, M. Denis, X. Zha; Proteins. R. Boujemaa-Paterski,1 A. Michelot,1 J. Remodeling and Cell Blebbing during Ottawa Health Research Institute, Ottawa, ON, Berro,1 C. Guérin,1 C. J. Staiger,2 J. Martiel,3 L. Pancreatic Acinar Cell Injury. V. P. Singh,1 M. A. Canada Blanchoin1; 1iRTSV-CEA Grenoble, Grenoble, McNiven2; 1Division of Gastroenterology and France, 2Department of Biological Sciences and Hepatology, Mayo Clinic, Rochester, MN, 2Division 1010 B147 Transcriptional Control of Apical The Bindley Bioscience Center, Purdue University, of Gastroenterology and Hepatology and Membrane Mechanics during Tube West Lafayette, IN, 3Laboratoire TIMC-TIMB, Department of Biochemistry and Molecular Biology, 1 1,2 Morphogenesis. B. E. Kerman, A. M. Cheshire, CNRS, Grenoble, France Mayo Clinic, Rochester, MN W. R. Zipfel,3,4 M. Myat,5 A. A. Spector,2 D. J. Andrew1; 1Cell Biology, Johns Hopkins Schl of 1018 B155 Isoform-specific Requirement of 1028 B165 Investigating the Role of Arp2/3 Medicine, Baltimore, MD, 2Biomedical Engineering, ADF/Cofilin for Assembly of the Contractile Complex in Cell Spreading and Cell Surface Johns Hopkins School of Medicine, Baltimore, MD, Actin Network in the C. elegans Somatic Protrusion Assembly. S. M. Nicholson-Dykstra, H. 3Developmental Resource for Biophysical Imaging Gonad. S. Ono, S. Yamashiro, K. Ono; Pathology, N. Higgs; Biochemistry, Dartmouth Medical School, & Opto-electronics, Cornell University, Ithaca, NY, Emory University, Atlanta, GA Hanover, NH 4Biomedical Engineering, Cornell University, Ithaca, NY, 5Cell and Developmental Biology, Weill Medical 1019 B156 Analysis of ADF/Cofilin-driven 1029 B166 Phosphorylated Caldesmon and College, Cornell University, New York, NY Fluctuations in Actin Filament Dynamics. L. Cortactin Synergistically Promotes Actin Blanchoin,1 J. Berro,1,2 J. Roland,2 A. Michelot,1 R. Polymerization. R. Huang, J. Kordowska, C. 1011 B148 Rapid Contractile Activation of Paterski-Boujemaa,1 C. Guérin,1 J. Martiel2; Wang; Muscle and Motility Group, Boston Cells Mediated by the Capsaicin Receptor 1Institut de Recherches en Technologie et Sciences Biomedical Research Institute, Watertown, MA TRPV1. B. Fabry,1 D. Freitag,1 C. Nau2; pour le Vivant, CEA Grenoble, Grenoble, France, 1Department of Physics, University of Erlangen- 2Laboratoire TIMC-TIMB, CNRS, Grenoble, France 1030 B167 Identification of a Cellular Nuremberg, Erlangen, Germany, 2Department of Factor That Retrieves Formins from Barbed Anesthesiology, University of Erlangen-Nuremberg, 1020 B157 Reanalysis of FLAP Data Ends of Actin Filaments to Maintain Proper 1 Erlangen, Germany Showing Rapid Actin Transport in Motile Actin Network Architecture. M. A. Chesarone, J. Lamellae. I. R. Kuznetsov, M. Herant, M. Dembo; B. Moseley,2 A. Michelot,3 S. Maiti,1 L. Blanchoin,3 1012 B149 Mathematical Modeling of Cell Biomedical Engineering, Boston University, Boston, B. Goode1; 1Brandeis University, Waltham, MA, Oscillations after Microtubules MA 2Rockefeller University, New York, NY, 3Institut de Depolymerization. M. Kapustina,1 G. Weinreb,1 N. Recherches en Technologie et Sciences pour le Costigliola,1 K. Jacobson,1 T. Elston2; 1Cell & 1021 B158 Cytoskeletal Remodeling Is Vivant, Grenoble, France Developmental Biology, University of North Actin Isoform-specific and Stimulus-specific. H. 1 1,2 2 1,2 Carolina, Chapel Hill, NC, 2Pharmacology, Kim, C. Gallant, P. Leavis, K. G. Morgan ; 1031 B168 Regulation of Actin Nucleation 1 University of North Carolina, Chapel Hill, NC Department of Health Sciences, Boston University, by the Formin, mDia1, through Rho GTPases. Boston, MA, 2Boston Biomedical Research C. L. Piffath, H. N. Higgs; Biochemistry, Dartmouth Institute, Watertown, MA Medical School, Hanover, NH Actin Dynamics and Assembly II 1022 B159 The Cdc42 Effector IRSp53 1032 B169 MyoGEF Promotes Actin Generates Filopodia by Coupling Membrane Polymerization via a Rho/mDia-dependent 1013 B150 Coronin Directs Cofilin Activity Protrusion with Actin Dynamics. L. K. B. Lim; Pathway. M. Asiedu, D. Wu, Q. Wei; Department to the Rear of Actin Networks through the Institute of Medical Biology, Singapore of Biochemistry, Kansas State University, Coordinated Effects of Two Separate Actin- Manhattan, KS binding Sites. M. Gandhi, B. L. Goode; Rosentiel 1023 B160 Control of VASP Localization Basic Medical Sciences Research Center, Brandeis and Activity by Zyxin. M. D. H. Hansen, M. 1033 B170 Modulation of Formin-mediated University, Waltham, MA Ascione, N. Bishop, J. Moody; Physiology and Actin Filament Elongation and Nucleation by Developmental Biology, Brigham Young University, Interaction of Profilin with the FH1 Domain. A. 1014 B151 Coronin 1B Debranches Actin Provo, UT Paul, T. Pollard; Molecular Biophysics and Filaments Generated by the Arp2/3 Complex. L. 1,2 3 4 1,2 Biochemistry, Yale University, New Haven, CT Cai, A. M. Makhov, D. A. Schafer, J. E. Bear ; 1024 B161 IQGAP1 Stimulates Actin 1 Department of Cell and Developmental Biology, Assembly through Arp2/3 Complex and N- 1034 B171 The Formin, FRL2, Converts University of North Carolina at Chapel Hill, Chapel WASP Coordinately with Cdc42 and Rac1. Y. Sheet-like Actin Protrusions to Finger-like 2 Hill, NC, Lineberger Comprehensive Cancer Cai,1 H. Kan,1 R. Luzes,2 G. S. Bloom1; Protrusions. H. N. Higgs, E. S. Harris; 3 Center, Chapel Hill, NC, Department of 1Department of Biology, University of Virginia, Biochemistry, Dartmouth Medical School, Hanover, Microbiology and Immunology, University of North Charlottesville, VA, 2Laboratorio de Bioquimica de NH Carolina at Chapel Hill, Chapel Hill, NC, Proteinas, Universidade Federal do Estado do Rio 4 Department of Biology and Cell Biology, University de Janeiro, Rio de Janeiro, Brazil 1035 B172 Bead Motility Mediated by Actin of Virginia, Charlottesville, VA Filaments Processively Capped by mDia1: A 1025 B162 Structural Basis for Inhibition of Model System to Study the Force Generated by 1015 B152 Molecular Architecture of the Arp2/3 Complex by Two Classes of Small Actin Bundles. J. Martiel; CNRS Grenoble, La 600 kDa Cyclase-associated Protein (CAP)-actin Molecule Inhibitors. B. J. Nolen,1 N. Tomasevic,2 Tronche, France Complex and Mechanism for Accelerating A. Russell,2 D. Pierce,2 J. Hartman,2 Z. Jia,2 R. Cofilin-mediated Actin Turnover. O. Quintero- Sakowicz,2 T. D. Pollard1; 1Molecular, Cellular and 1036 B173 The Formin FRL (FMNL1) Is 1 2 1 1 Monzon, E. Bertling, E. Jonnasson, L. Talarico, Developmental Biology, Yale University, New Upregulated in Macrophage Differentiation and 2 2 1 1 M. Sihvo, P. Lappalainen, B. L. Goode ; Biology, Haven, CT, 2Cytokinetics, Inc., South San Localizes to Podosomes. A. T. Mersich, S. D. 2 Brandeis University, Waltham, MA, University of Francisco, CA Blystone; Cell & Developmental Biology, SUNY Helsinki, Helsinki, Finland Upstate Medical University, Syracuse, NY 1026 B163 Arp2/3 Nucleating Activity and 1016 B153 TMD-1, a Caenorhabditis Lamella Formation Are Determined by 1037 B174 The Formin INF2 Mediates Actin elegans Tropomodulin, Inhibits ADF/Cofilin- Phosphorylation of Arp2. L. L. LeClaire,1 M. Assembly and Disassembly on the dependent Actin Filament Depolymerization. S. Baumgartner,1 J. H. Iwasa,2 R. D. Mullins,2 D. L. Endoplasmic Reticulum. E. Seth Chhabra, V. 1 2 2 1 Yamashiro, E. A. Cox, J. Hardin, S. Ono ; Barber1; 1Cell and Tissue Biology, University of Ramabhadran, H. N. Higgs; Biochemistry, 1 Pathology, Emory University, Atlanta, GA, California, San Francisco, San Francisco, CA, Dartmouth College, Hanover, NH 2 Zoology, University of Wisconsin, Madison, WI 2Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA Cell Polarity

1038 B175 Redirecting Yeast Polarity with Electric Fields. N. Minc, F. Chang; Microbiology, Columbia University, New York, NY

108 The American Society for Cell Biology 47th Annual Meeting MONDAY December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org Poster Session 2 B176–B205

1039 B176 Adjacent Positioning of Cellular 1050 B187 Noncanonical Wnt Signaling 1059 B196 Down-regulation of SRG3 Is Structures Enabled by a Cdc42 GAP-mediated Regulates Polarity of the Microtubule Required for Thymocyte Selection. J. Ahn, K. Zone of Inhibition. Z. Tong,1 X. Gao,2 A. S. Cytoskeleton in Dorsally Converging Cells Lee, Y. Choi, R. H. Seong; Institute of Molecular Howell,3 I. Bose,3 D. J. Lew,3 E. Bi1; 1Department during Zebrafish Gastrulation. D. S. Sepich, A. L. Biology & Genetics and School of Biological of Cell and Developmental Biology, University of Pawlicki, L. Solnica-Krezel; Department of Sciences, Seoul National University, Seoul, Pennsylvania, Philadelphia, PA, 2State Key Biological Sciences, Vanderbilt University, Republic of Korea Laboratory of Virology, Wuhan University, Wuhan, Nashville, TN China, 3Department of Pharmacology and Cancer 1060 B197 MHCII Expression Profiling and Biology, Duke University Medical Center, Durham, 1051 B188 A Cdc42-Cofilin Pathway Endogenous Antigen Estimation of Thymic NC Contributes to the Establishment of Neuronal Epithelial Cell Subcompartments for the Study Polarity. K. C. Flynn,1 B. Garvalov,2 D. of Thymic Development. S. H. Lee, H. S. Shin, D. 1040 B177 The GmpA Localization Factor Neukirchen,2 L. Meyn,2 N. Teusch,3 X. Wu,4 C. J. Lee, M. C. Kim, M. G. Kim; Biological Sciences, Mediates Assembly of Cell Poles in Brakebusch,4 F. Bradke,2 J. R. Bamburg1; Inha University, Incehon, Republic of Korea Caulobacter. G. R. Bowman,1 L. R. Comolli,2 L. 1Biochemistry and Molecular Biology, Colorado Shapiro1; 1Developmental Biology, Stanford State University, Fort Collins, CO, 2Axonal Growth 1061 B198 Foxn1 Expression in Thymic University, Stanford, CA, 2Life Sciences Division, and Regeneration Group, Max Planck Institute of Epithelium Is Required to Maintain the 1 1 2 Lawrence Berkeley National Laboratory, Berkeley, Neurobiology, Martinsried, Germany, 3Molecular Postnatal Thymus. L. Chen, S. Xiao, D. Su, N. 1 1 CA Biology and Biochemistry, Abbott GmbH & Co. KG, R. Manley ; Genetics, University of Georgia, 2 Ludwigshafen, Germany, 4Molecular Pathology, Athens, GA, University of Texas Health Center, 1041 B178 The Role of Toca in Endocytosis University of Copenhagen, Copenhagen, Denmark Tyler, TX and Convergent Extension in Xenopus Embryos. J. L. Gallop, M. W. Kirschner; 1052 B189 The Polarity Protein Par-3 1062 B199 Regulation of Rac2 Gene Department of Systems Biology, Harvard Medical Interacts with the Type1 Protein Phosphatase Expression during Myeloid Cell Differentiation. 1,2 1,2 School, Boston, MA PP1. A. Traweger, L. Taylor, P. Metalnikov, T. R. Muthukrishnan, D. G. Skalnik ; 1 Pawson; Samuel Lunenfeld Research Institute, Departments of Pediatrics and Biochemistry and 1042 B179 The Role of Actin, Myosin, Mount Sinai Hospital, Toronto, ON, Canada Molecular Biology, Indiana University School of Microtubules, and Endocytosis during Xenopus Medicine, Indianapolis, IN, 2Herman B. Wells Bottle Cell Apical Constriction. J. Lee, R. M. 1053 B190 Expression and Function of Center for Pediatric Research, Section of Pediatric Harland; Department of Molecular and Cell Biology, Strad-alpha and Strad-beta, Two Co-activators Hematology/Oncology, Indiana University School of University of California, Berkeley, Berkeley, CA of LKB1 in the Developing Brain. A. P. Barnes,1 Medicine, Indianapolis, IN H. I. Bishop,1 F. Polleux1,2; 1UNC-Neuroscience 1043 B180 Ryk Is a Novel Regulator of Center, University of North Carolina–Chapel Hill, 1063 B200 Delayed Muscle Differentiation -/- Convergent Extension Movements in Xenopus Chapel Hill, NC, 2Department of Pharmacology, Kinetics in LMNA Myoblasts. R. L. Frock, S. C. laevis. G. Kim, J. Her, J. Han; Division of University of North Carolina–Chapel Hill, Chapel Chen, B. A. Kudlow, A. M. Evans, S. A. Jameson, Molecular and Life Sciences, Pohang University of Hill, NC S. D. Hauschka, B. K. Kennedy; Biochemistry, Science and Technology, Pohang, Republic of University of Washington, Seattle, WA Korea 1054 B191 Molecule Mechanism for Symmetry Breaking and Chromosome 1064 B201 Proteomic Analysis of 1044 B181 Early Establishment of Apical- Movement in Mouse Meiosis I. H. Li, R. Li; Drosophila Fragile X Mutant Cleavage Stage 1 2 2 Basal Polarity in Cleaving Embryos Regulated Stowers Institute for Medical Research, Kansas Embryos. K. Monzo, S. R. Dowd, J. S. Minden, 1 1 by aPKC and Actin. L. M. Alford, M. M. Ng, D. R. City, MO J. S. Sisson ; Section of Molecular Cell and Burgess; Biology, Boston College, Chestnut Hill, Developmental Biology and Institute for Cellular MA and Molecular Biology, The University of Texas at Development and Aging Austin, Austin, TX, 2Department of Biological 1045 B182 Exploring the Role of GTPase Sciences, Carnegie Mellon University, Pittsburgh, Signaling in the Establishment and 1055 B192 The Role of Histone PA Maintenance of Polarity in C. elegans Embryos. Modifications in Epigenetic Control of Nodal K. T. Kumfer, J. G. White; Laboratory of Molecular 1065 B202 Molecular Systems Biology of Gene Expression. O. Dahle, M. Kuehn; LPDS, Biology, University of Wisconsin, Madison, Aging: Using Yeast as a Model System for NCI-Frederick, Frederick, MD Madison, WI Defining a Modular Network Controlling 1056 B193 A Role of Protein Arginine Chronological Aging. A. Goldberg, C. Gregg, T. 1046 B183 Applying Purified Wnt Signals Methytransferase 1 in the Transcriptional Boukh-Viner, S. Bourque, P. Kyryakov, T. Guo, Z. to Single Cells to Understand Wnt's Role in Cell Regulation by Thyroid Hormone Receptor Aziz, A. Chang, D. Cyr, S. Kenth, S. Milijevic, M. Polarization. M. Roh,1 A. J. Mikels,2 R. Nusse,2 B. during Xenopus metamorphosis. H. Matsuda, B. Noei, R. Noei, N. Ramlal, J. Solomon, V. Wong, V. Goldstein1; 1University of North Carolina–Chapel Paul, C. Choi, Y. Shi; National Institue of Child Titorenko; Biology Department, Concordia Hill, Chapel Hill, NC, 2Stanford University, Stanford, Health and Human Development, National University, Montreal, PQ, Canada CA Institutes of Health, Bethesda, MD 1066 B203 A New Cell Energizer That 1047 B184 An Experimental and Theoretical 1057 B194 DNase I-resistant DNA-PK Improves Significantly Cell Defense against Study of Assymetric Protein Partition in a Activity in Xenopus Oocytes and Nuclear Stress. C. Dal Farra, E. Bauza, I. Imbert, N. Developing Embryo. B. R. Daniels, D. Wirtz; Localization of Its Cofactor, Ku during Early Domloge; Skin Research Center, Vincience, ISP, Chemical and Biomolecular Engineering, Johns Embryogenesis. J. Kanungo1,2; 1GTB, NHGRI, Sophia Antipolis, France Hopkins University, Baltimore, MD NIH, Bethesda, MD, 2Institute of Molecular 1067 B204 Increased Expression of Medicine and Genetics, Medical College of 1048 B185 Functions of the Novel Immortalization-upregulated Protein 2 (IMUP-2) Georgia, Augusta, GA RhoGAPs RGA-3 and RGA-4 in the Germ Line in Pre-eclampsia Placenta. S. Jeon,1 H. Chung,1 and in the Early Embryo of C. elegans. C. 2 2 3 1 1 1058 B195 The HIM-8 and ZIM Zinc Finger H. Lee, K. Shin, M. Lee, J. Kim, G. Kim ; Schmutz, J. Stevens, A. Spang; Biozentrum, 1 Proteins Broadly Regulate Transcription Factor Pochon CHA University, Seoul, Republic of Korea, University of Basel, Basel, Switzerland 2 Activity during C. elegans Development. H. Chabiotech Co., Ltd., Seoul, Republic of Korea, 1 2 1 3School of Veterinary Medicine, Kangwon National 1049 B186 Lgl and Its Regulation by aPKC Sun, W. Hanna-Rose ; Intercollege Graduate University, Chuncheon, Republic of Korea Are Required for Oocyte Polarity Formation in Degree Program in Genetics, Penn State University, University Park, PA, 2Biochemistry and Drosophila. A. Tian, W. Deng; Department of 1068 B205 Cytokines and Longevity in Molecular Biology, Penn State University, University Biological Science, Florida State University, Turkish Population. K. Ozdilli,1,2 Y. Ogret,1 F. Park, PA Tallahassee, FL Oguz,1 H. Issever,1 M. Carin,1 G. Gedikoglu2; 1Istanbul University, Istanbul, Turkey, 2Halic University, Istanbul, Turkey

109 MONDAY The American Society for Cell Biology 47th Annual Meeting Poster Session 2 B206–B233 December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org

1069 B206 Glycosphingolipid and 1080 B217 Regulation of G␣ Palmitoylation 1090 B227 Clathrin Functions in the Glycogene Expression in Developing Mouse by DHHC Protein. R. Tsutsumi,1 Y. Fukata,1 M. Absence of the Terminal Domain Binding Site Brain. R. K. Yu, S. Ngamukote, M. Yagagisawa, T. Fukata1,2; 1Division of Membrane Physiology, for Adaptor-associated Clathrin-Box Motifs. J. Ariga; Institute of Molecular Medicine and Genetics, National Institute of Physiological Science, R. Collette,1 L. M. Traub,2 M. Geli,3 A. J. Merz,4 S. Medical College of Georgia, Augusta, GA Okazaki, Aichi, Japan, 2PRESTO, Japan Science K. Lemmon1; 1Department of Molecular and and Technology Agency, Chiyoda, Tokyo, Japan Cellular Pharmacology, University of Miami, Miami, FL, 2Department of Cell Biology and Physiology, Organogenesis 1081 B218 Subcellular Distribution and University of Pittsburgh School of Medicine, Intracellular Routes for Trafficking of Diacylated Pittsburgh, PA, 3Departamento de Biologia 1070 B207 Rapid Regeneration in the GAP-43. A. Trenchi, G. A. Gomez, J. L. Daniotti; Molecular y Celular, Instituto de Biologia Molecular Ctenophore Mnemiopsis. A. G. Moss, M. B. Departamento de Química Biológica, CIQUIBIC de Barcelona, Barcelona, Spain, 4Department of Dodson; Biological Sciences, Auburn University, (CONICET-UNC), Facultad de Ciencias Químicas, Biochemistry, University of Washington, Seattle, Auburn, AL Universidad Nacional de Córdoba, Córdoba, WA Argentina 1071 B208 Cell Motility during Mammary 1091 B228 A Diaspartate Motif Is Required Epithelial Branching is MMP-dependent but 1082 B219 Phosphatidylserine Dictates for Direct Binding of HIV Nef to the Clathrin Proteolysis-independent. C. M. Nelson,1,2 J. L. Organellar and Phagosomal Surface Charge Adaptor Complex AP2. W. Lindwasser,1 W. J. Inman,2 H. Mori,2 M. J. Bissell2; 1Princeton and Targeting of Polycationic Proteins. T. Y. Smith,1 R. Chaudhuri,1 P. Yang,1 J. H. Hurley,2 J. 1 2 1 1 University, Princeton, NJ, 2Lawrence Berkeley Yeung, A. Kapus, S. Grinstein ; Program in Cell S. Bonifacino1; 1Cell Biology and Metabolism National Laboratory, Berkeley, CA Biology, The Hospital For Sick Children, Toronto, Branch, National Institute of Child Health and 2 ON, Canada, Department of Surgery, University of Human Development, National Institutes of Health, 1072 B209 Mutagenesis Screen in C. Toronto, Toronto, ON, Canada Bethesda, MD, 2Laboratory of Molecular Biology, elegans Reveals Genes Involved in Pharynx 1083 B220 Localization and Trafficking of National Institute of Diabetes and Digestive and Muscle Fate. A. R. Ferrier, P. A. Smith; Biology, Kidney Diseases, National Institutes of Health, Lake Forest College, Lake Forest, IL GLUT12 in CHO and HEK293 Cells. L. B. V. Flessner, K. Moley; OB/GYN, Washington Bethesda, MD 1073 B210 Rbp1b as an Early Gall Bladder University in St. Louis, St. Louis, MO 1092 B229 Connecdenn, a Novel Clathrin- Organogenesis Marker in Zebrafish Embryos. P. coated Vesicle Associated Protein Linking K. Barnett, L. P. Hammonds-Odie; Biology 1084 B221 N-Linked Glycans Mediate the Apical Localisation of Angiotensin Converting DENN Domains to Endocytic Vesicle Trafficking. Department, Spelman College, Atlanta, GA 1 B. Ritter,1 C. Dall'Armi,2 G. Di Paolo,2 Enzyme 2. B. W. Y. Chow,1 S. Song,1 W. H. P. D. Allaire, P. S. McPherson1; 1Neurology and Neurosurgery, 1074 B211 Expression of Myogenin, but d'Avigdor,1 G. W. McCaughan,1 N. A. Shackel,1 F. Montreal Neurological Institute, McGill University, Not of MyoD, Is Temperature-sensitive in Mouse J. Warner1,2; 1Liver Immunobiology, Centenary 2Pathology and Cell Skeletal Muscles. A. Shima, R. Matsuda; Institute, Newtown, Australia, 2Faculty of Medicine, Montreal, PQ, Canada, Graduate School of Arts and Sciences, The University of Sydney, Sydney, Australia Biology, Columbia University Medical Center, New University of Tokyo, Tokyo, Japan York, NY 1085 B222 VAMP4 Cycles from the Surface 1093 B230 Structural Analysis of Dynamin 1075 B212 Cleavage of B Class Ephrins by to the trans-Golgi Network via the Sorting and ADAMs 13 and 19: Role in Craniofacial Recycling Endosome. T. Tran, Q. Zeng, W. Hong; Domains. P. Ray, S. Fang, J. A. Mears, J. E. Development through Regulation of Slug. S. Institute of Molecular and Cell Biology, Singapore Hinshaw; Laboratory of Cell Biochemistry and Wei,1 L. C. Bridges,1 P. Williams,1 C. Whittaker,2 S. Biology, NIDDK/NIH, Bethesda, MD 1 D. W. DeSimone,1 J. M. White1; 1Cell 1086 B223 Analyzing the Palmitoylation of O’Neill, 1094 B231 Endocytosis of the Transferrin Biology, University of Virginia, Charlottesville, VA, CD-MPR as a Trafficking Switch. B. G. H. Filippi, Receptor Is Mediated by Src Activation of a 2Center for Cancer Research, Massachusetts A. J. Hulsmeier, T. Hennet, J. Rohrer; Physiology, 1 J. University of Zurich, Zurich, Switzerland Dynamin 2-Cortactin Complex. H. Cao, Institute of Technology, Cambridge, MA Chen,1 M. A. McNiven2; 1Division of 1076 B213 EGL-26, a Putative 1087 B224 The Prosaposin C-terminus Gastroenterology and Hepatology, Mayo Clinic, 2 Palmitoyltransferase, Promotes Cellular Contains a Sequence Required for Its Transport Rochester, MN, Division of Gastroenterology and Morphogenesis in the C. elegans Vulva. K. A. to the Lysosomes. L. Yuan, C. R. Morales; Hepatology and Department of Biochemistry and Estes,1 R. Kalamegham,2 W. Hanna-Rose1; Anatomy & Cell Biology, McGill University, Molecular Biology, Mayo Clinic, Rochester, MN 1 Montreal, PQ, Canada Biochemistry, Molecular Biology, The Pennsylvania 1095 B232 Direct Dynamin-Actin State University, University Park, PA, 2Cell and 1088 B225 Multiply Phosphorylated Interactions Promote Dynamin Self-Assembly in Developmental Biology, NIDDK, National Institutes Intrinsically Unstructured Domain Regulates the Cytoplasm. C. Gu,1 A. Weins,2 J. Skoch,3 D. of Health, Bethesda, MD Secretory Granule Membrane Protein Ko,1 J. Reiser,1 B. T. Hyman,3 B. J. Bacskai,3 J. 2 2 1 1 1077 B214 The Migrating C. elegans Linker Trafficking. C. Rajagopal,1 R. E. Mains,2 B. A. Hartwig, M. Polak, S. Sever ; Nephrology Cell Changes in Response to a Developmental Eipper1; 1Molecular Microbial and Structural Division, Department of Medicine, Harvard Medical Clock. M. Kato, P. W. Sternberg; Biology, California Biology, University of Connecticut Health Center, School and Massachusetts General Hospital, 2 Institute of Technology, Pasadena, CA Farmington, CT, 2Neuroscience, University of Boston, MA, Renal Division, Harvard Medical Connecticut Health Center, Farmington, CT School and Brigham and Women's Hospital, Boston, MA, 3Alzheimer's Disease Research Protein Targeting Laboratory, Department of Medicine, Harvard Endocytic Machinery: Structure, Function, and Medical School and Massachusetts General 1078 B215 A High-Content Screen in S. Regulation Hospital, Boston, MA cerevisiae to Examine Tail-Anchor Protein 1096 B233 Cargo and Dynamin Regulate Targeting to the Endoplasmic Reticulum. M. P. 1089 B226 Small Angle Neutron Scattering Maturation Checkpoints in Clathrin-mediated A. Henderson,1 T. J. Collins,1 J. Guzzo,2 B. (SANS) Studies of Clathrin Triskelia in Solution. Endocytosis. D. Loerke, M. Mettlen, D. Yarar, K. Andrews,2 D. W. Andrews1; 1Biochemistry and M. L. Ferguson,1,2 K. Prasad,3 H. Boukari,1 D. L. Jaqaman, S. Schmid, G. Danuser; The Scripps Biomedical Sciences, McMaster University, Sackett,1 S. Krueger,4 E. M. Lafer,3 R. J. Nossal1; Research Institute, La Jolla, CA Hamilton, ON, Canada, 2Donnelly Centre for 1LIMB, NICHD, Bethesda, MD, 2Department of Cellular and Biomolecular Research, University of Physics, University of Maryland, College Park, MD, Toronto, Toronto, ON, Canada 3Department of Biochemistry, University of Texas Health Science Center, San Antonio, TX, 4NIST 1079 B216 Melanosome Recruitment of Center for Neutron Research, National Institute of Rab27 Occurs Independently of Nucleotide Standards and Technology, Gaithersburg, MD Exchange and Effector Engagement. A. Figueiredo, A. Tarafder, C. Wasmeier, R. Baron, M. C. Seabra; NHLI, Imperial College London, London, United Kingdom

110 The American Society for Cell Biology 47th Annual Meeting MONDAY December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org Poster Session 2 B234–B262

1097 B234 Degradative Sorting of the EGF 1108 B245 Functional Architecture of the 1116 B253 ACAP4 Interacts with Ezrin and Receptor Is Mediated by Association of Retromer Cargo-Recognition Complex. A. Regulates Histamine-stimulated Parietal Cell Dynamin 2 with the Ubiquitin-linked Endocytic Hierro,1 A. L. Rojas,1 R. Rojas,2 M. Murthy,2 G. Secretion. F. Wang,1 X. Ding,2 P. Xia,1 X. Gao,1 H. Machinery at the Late Endosome. B. Schroeder,1 Effantin,3 A. V. Kajava,4 A. C. Steven,3 J. S. Deng,1 X. Yu,1 Z. Guo,1 X. Yao1; 1Polarity and J. Chen,1 D. D. Billadeau,2 M. A. McNiven3; Bonifacino,2 J. H. Hurley1; 1NIDDK/LMB, National Epithelial Secretion, Institute of Cellular Dynamics, 1Division of Gastroenterology and Hepatology, Institutes of Health (NIH), Bethesda, MD, 2NICHD/ Hefei, China, 2Medicine, Beijing University of Mayo Clinic, Rochester, MN, 2Department of CBMB, National Institutes of Health (NIH), Chinese Medicine, Beijing, China Immunology, Mayo Clinic, Rochester, MN, 3Division Bethesda, MD, 3NIAMS/LSB, National Institutes of of Gastroenterology and Hepatology and Health (NIH), Bethesda, MD, 4Centre de 1117 B254 Actin-coated Granules in Human Department of Biochemistry and Molecular Biology, Recherches de Biochimie Macromolecularie, Umbilical Cord Endothelial Cells Undergoing Mayo Clinic, Rochester, MN Centre National de la Recherche Scientifique Regulated Exocytosis. L. F. van Driel, K. M. (CNRS), Montpellier, France Valentijn, T. J. Arends, K. A. Jansen, A. J. Koster, 1098 B235 Endofin Recruits Clathrin to J. A. Valentijn; Molecular Cell Biology, Leiden Early Endosomes via TOM1. N. Liu; IMCB, 1109 B246 FIP1/RCP Binding to Golgin-97 University Medical Center, Leiden, The Netherlands Singapore Regulates the Sorting of Membrane Proteins from Early Endosomes to the Retrograde 1118 B255 Calcineurin Is Involved in Lytic 1099 B236 Characterizing the Transport Pathways. J. Jing,1 J. Burden,2 A. Ggranule Exocytosis in NK-92 Human Leukemic Conformations of the Yeast Endocytic Scaffold Peden,3 R. Prekeris1; 1Cell and Development Natural Killer Cells. A. T. Pores-Fernando, S. Protein Pan1. B. Pierce, B. Wendland; Biology, Biology, University of Colorado Health Science Gaur, A. Zweifach; Molecular and Cell Biology, Johns Hopkins University, Baltimore, MD Center, Aurora, CO, 2MRC Cell Biology Unite, University of Connecticut, Storrs, CT University College London, London, United 1100 B237 AAK1 Regulates Numb Function 1119 B256 Characterization of Regulated Kingdom, 3Cambridge Institute for Medical as an Endocytic Adaptor. E. B. Sorensen, S. D. Secretion in Three-Dimensionally Grown Human Research, Cambridge, United Kingdom Conner; Genetic, Cell Biology and Development, Submandibular Gland Cell (HSG). M. Aye, R. University of Minnesota, Minneapolis, MN 1110 B247 The Epithelial Ca2+ TRPV5 Is Weigert; OPCB/IMTU, NIH/NIDCR, Bethesda, MD Internalized via Clathrin-dependent Endocytosis 1101 B238 Essential Role of GAK (auxilin-2) 1120 B257 Secretory Granule Maturation in to Enter a Ca2+-controlled Recycling Pathway. in Developing and Mature Mice. Y. Yim,1 D. Lee,2 Human Islets Results in Basal Release of S. F. J. van de Graaf,1,2 U. Rescher,2 J. G. J. E. Eisenberg,1 L. Greene1; 1NHLBI, NIH, Bethesda, Incompletely Processed Proinsulin. R. Kuliawat; Hoenderop,3 R. J. M. Bindels,3 V. Gerke2; MD, 2Department of Life Science, Pohang Endocrinology and Department of Molecular and 1Department of Metabolic and Endocrine Diseases, University of Science and Technology, Pohang, Developmental Biology, Albert Einstein College of University Medical Center Utrecht/Wilhelmina Republic of Korea Medicine, Bronx, NY Children's Hospital, Utrecht, The Netherlands, 1102 B239 Epsin Functions as Clathrin 2Institute of Medical Biochemistry, Center for 1121 B258 Visualization of von Willebrand Adaptor for Protease-activated Receptor-1 Molecular Biology of Inflammation, University of Factor Exocytosis from Endothelial Cells by 3D Internalization. J. Trejo; Pharmacology, University Münster, Muenster, Germany, 3Department of Electron Microscopy. K. M. Valentijn, T. J. of North Carolin at Chapel Hill, Chapel Hill, NC Physiology, Nijmegen Centre for Molecular Life Arends, L. F. van Driel, K. A. Jansen, J. A. Sciences, Radboud University Nijmegen Medical Valentijn, A. J. Koster; Molecular Cell Biology, 1103 B240 Epsin Coordinates Endocytosis Centre, Nijmegen, The Netherlands Leiden University Medical Center, Leiden, The and Signaling by Interacting with the Cdc42/ Netherlands Rac1-Binding Proteins RalBP1 and OCRL1. B. 1111 B248 Linking Clathrin-mediated Coon,1 D. Mukherjee,1 J. Camonis,2 R. Aguilar1; Membrane Trafficking to Phosphoinositide 1122 B259 Toxoplasma PRP1 Is an 1Biological Sciences, Purdue University, West Metabolism: Structural Studies of the Lowe Ortholog of Parafusin (PFUS) in Vesicle Lafayette, IN, 2Institut Curie, Paris, France Syndrome Protein OCRL. Y. Mao, K. Erdmann, H. Scaffold Assembly in Ca2+ Regulated McCrea, R. Zoncu, D. Toomre, P. De Camilli; Cell Exocytosis. L. Liu, S. C. Tucker, B. H. Satir; 1104 B241 A Novel Sorting Nexin Biology, Yale University School of Medicine, New Anatomy and Structural Biology, Albert Einstein Modulates Endocytic Protein Trafficking and Haven, CT College of Medicine, Bronx, NY Activates Insulin Signaling. S. Schöbel,1 S. Neumann,1 M. Hertweck,2 B. Dislich,1 E. 1112 B249 Regulatory Regions in the Mss4 Kremmer,3 R. Baumeister,2 C. Haass,1 S. F. PIP 5-Kinase Critical for Plasma Membrane Membrane Channels Lichtenthaler1; 1Ludwig-Maximilians-University, Recruitment and PIP Kinase Activity. Y. Ling, C. Munich, Germany, 2University of Freiburg, Freiburg, J. Stefan, S. D. Emr; Institute for Cell and 1123 B260 The Cataract Inducing Cx50- Germany, 3GSF, Munich, Germany Molecular Biology & Department of Molecular S50P Mutation Dominantly Alters Wild-Type Biology and Genetics, Cornell University, Ithaca, Lens Connexin Channel Gating. A. M. DeRosa,1 1105 B242 Role of EHD4 in Regulating NY C. Xia,2 X. Gong,2 T. W. White3; 1Genetics, SUNY Early Endosomal Transport and Biogenesis. M. Stony Brook, Stony Brook, NY, 2School of Sharma, J. Rahajeng, N. Naslavsky, S. Caplan; Optometry and Vision Science Program, University Biochemistry and Molecular Biology, University of Exocytosis: Regulated Secretion of California at Berkeley, Berkeley, CA, 3Physiology Nebraska Medical Center, Omaha, NE and Biophysics, SUNY Stony Brook, Stony Brook, 1113 B250 Modulation of Discoidal Vesicle NY 1106 B243 Ehd2 Inhibits Endocytosis Exocytosis by the Rab11a GTPase. P. through Regulation of Rac-1 Activity. S. Khandelwal,1 O. A. Weisz,1 J. R. Goldenring,2 G. 1124 B261 Connexin43 Modulates Polarized Benjamin,1 H. Weidberg,1 K. Hirshberg,2 S. Apodaca1; 1School of Medicine, University of Cell Morphology and Directional Cell Migration Katzav,3 M. Horowitz1; 1Cell Research and Pittsburgh, Pittsburgh, PA, 2Vanderbilt University through Tubulin Interaction and the Assembly Immunology, Tel Aviv University, Ramat Aviv, Medical Center, Vanderbilt University, Nashville, TN of Stabilized Microtubules. R. J. B. Francis,1 X. Israel, 2Pathology, Sackler School of Medicine, Tel Xu,1 K. Park,1 C. Wei,1 S. Chang,1 S. Alaei,2 B. Aviv University, Ramat Aviv, Israel, 3The Hubert 1114 B251 GDI Isoform Expression and Charterjee,1 C. Bulinsky,2 C. W. Lo1; 1Laboratory of Humphry Center for Experimental Medicine and Localization in Dexamethasone-treated AR42J Developmental Biology, NHLBI/NIH, Bethesda, MD, Cancer Research, Hebrew University, Jerusalem, Cells. R. Raffaniello, S. Rafiq; Medical Laboratory 2Biology Department, Columbia University, New Israel Sciences, Hunter College, New York, NY York, NY 1107 B244 Structure of the EH Domain of 1115 B252 Cdk5 Regulation of Vimentin 1125 B262 Role of C-terminus in the EHD1 and Its Role in Membrane Association. M. Dynamics during GTP-induced Secretion from Opening of Connexin43 Hemichannels and Gap Jovic; University of Nebraska Medical Center, Neutrophils. J. L. Rosales, L. Liu, K. Lee; Channels Induced by Dithiothreitol. M. Omaha, NE Biology and Anatomy, The University of Calgary, A. Retamal, S. Yin, G. A. Altenberg, L. Reuss; Calgary, AB, Canada Physiology, Texas Tech University Health Science Center, Lubbock, TX

111 MONDAY The American Society for Cell Biology 47th Annual Meeting Poster Session 2 B263–B290 December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org

1126 B263 TRPV2 Knockdown Suppresses 1135 B272 Study of Subunits Interactions 1143 B280 The Decrease in Large-Solute the Stretch-induced Ca2+ Increase and of Serine Palmitoyltransferase Complex by Permeability of Connexin 43 Gap-Junctional Subsequent Cellular Responses in HUVEC. Y. Using Fusion Approach. G. Han,1 L. Yan,2 K. Hemichannels (Cx43 GJH) by PKC-mediated Katanosaka, K. Naruse; Cardiovascular Physiology, Gable,1 J. M. Harmon,3 T. M. Dunn1; 1Biochemistry Phosphorylation Is a Cooperative Phenomenon. Okayama Univ, Okayama, Japan and Molecular Biology, Uniformed Services S. C. Lee,1 L. Reuss,2 G. A. Altenberg2; 1Internal University of the Health Sciences, Bethesda, MD, Medicine, University of Texas Medical Branch, 1127 B264 Fluid Flow Acts as Both a 2Microbiology and Immunology, Uniformed Services Galveston, TX, 2Cell Physiology and Molecular Mechanical Stimuli to Ion Channels and a University of the Health Sciences, Bethesda, MD, Biophysics, Texas Tech University Health Sciences Source of Artifacts in a Patch Clamp Study. S. 3Pharmacology, Uniformed Services University of Center, Lubbock, TX Park, Y. Bae; Konkuk University, Choongju, the Health Sciences, Bethesda, MD Republic of Korea 1144 B281 Identification of a Novel Second 1136 B273 The Lcb2p Subunit of Serine Site Suppressor Mutation in a Misfolded Variant 1128 B265 Hypertonicity Induces Cytosol- Palmitoyltransferase Is Degraded by the of the Yeast ABC Transporter, Yor1p. R. J. Louie, to-Membrane Translocation of Clns1a and Its Proteasome. S. D. Gupta,1 G. Han,1 K. Gable,1 L. E. Miller; Biological Sciences, Columbia University, ␥ Interaction with the Subunit of the Na/K- Yan,2 J. M. Harmon,3 T. M. Dunn1; 1Biochemistry New York, NY ATPase in Inner Medullary Collecting Duct and Molecular Biology, USUHS, Bethesda, MD, (IMCD3) Cells. M. A. Lanaspa, A. Andres- 2Microbiology and Immunology, USUHS, Bethesda, 1145 B282 The Tetraspanin CD9 Negatively ␤ Hernando, C. J. Rivard, S. Y. Breusegem, N. P. MD, 3Pharmacology, USUHS, Bethesda, MD Regulates Wnt Signaling by Destabilizing - Barry, N. E. Almeida, T. Berl; Renal Medicine, catenin via a GSK-3␤-independent Pathway. A. University of Colorado Health Sciences Center, 1137 B274 Lateral Heterogeneity and Chairoungdua, D. Smith, M. Caplan; Cellular and Denver, CO Diffusion Patterns of Major Histocompatibility Molecular Physiology, Yale University, New Haven, Complex (MHC) Class I Proteins in Membrane CT 1129 B266 Glucose-induced Spatial Blebs. F. S. Ariola,1 M. Kyoung,2 E. D. Sheets,2 M. + + Interactions between L-type Voltage Dependent Edidin,3 A. A. Heikal1; 1Bioengineering, 1146 B283 EGF Upregulates Na /H Calcium Channel and Calcium Sensing Pennsylvania State University, University Park, PA, Exchanger NHE1 by Post-translational Receptor. J. Parkash; Department of 2Chemistry, Pennsylvania State University, Regulation That Is Important for Cervical Environmental and Occupational Health, Florida University Park, PA, 3Biology, Johns Hopkins Cancer Cell Invasiveness. M. Shen; Department International University, Robert Stempel School of University, Baltimore, MD of Pharmacology, National Cheng Kung University, Public Health, Miami, FL College of Medicine, Taiwan, Taiwan 1138 B275 Fragmented Forms of Galectin 1130 B267 The NALCN Cation Channel Is Related Inter-Fiber Protein Are Uniquely 1147 B284 arNOX: An Aging-related Cell Modulated by Muscarinic M3 Receptors Associated with the Water Insoluble Membrane Surface Protein and Cardiovascular Risk. D. M. 1 2 1 Independently of G Protein Activation in a Fraction of Normal Rat Lens. A. F. Alviar,1 C. R. Morre, D. Morre ; Foods and Nutrition, Purdue ␤ 1 2 Pancreatic -Cell Line. L. Swayne, A. Fleschner,2 M. K. Stuart1; 1Microbiology/ University, West Lafayette, IN, Medicinal 1 1 1 Mezghrani, A. Varrault, G. Bertrand, E. Immunology, A. T. Still University, Kirksville, MO, Chemistry and Molecular Pharmacology, Purdue 1 1 2 1 Bourinet, S. Dalle, R. J. Miller, J. Nargeot, A. 2Biochemistry, A. T. Still University, Kirksville, MO University, West Lafayette, IN Monteil1; 1Physiology, CNRS - IGF, Montpellier, France, 2Molecular Pharmacology and Biological 1139 B276 SVCT2 and GLUT1 Are Involved 1148 B285 Monitoring pH Homeostasis in 1 1 2 Chemistry, Northwestern University Medical School, in the Uptake of Vitamin C to the Central S. cerevesiae. J. Agee, C. Bauerle, D. Botstein ; 1 2 Chicago, IL Nervous System. V. Ulloa, M. García, K. Reinicke, Biology, Spelman College, Atlanta, GA, Molecular F. Pérez, F. Nualart; Cellular Biology, University of Biology, Princeton University, Princeton, NJ 1131 B268 ML-9 Inhibits Store-operated Concepcion, Concepcion, Chile Calcium Entry by Reversing Store Depletion- 1149 B286 The Effect of induced Stim1 Rearrangement. J. T. Smyth, W. I. 1140 B277 ARF Proteins are GTP- Tetraethylammonium Chloride on the Kinetics DeHaven, G. S. Bird, J. W. Putney; Laboratory of dependent Membrane Benders. M. Krauss,1 J. of Osmotically-induced Hemolysis of Signal Transduction, NIEHS/NIH, Research Jia,1 A. Roux,2 P. de Camilli,3 V. Haucke1; 1Institut Mammalian Red Blood Cells. J. Pickens, S. Triangle Park, NC fuer Chemie & Biochemie, Freie Universitaet Berlin, Gallik; Biology, University of Mary Washington, Berlin, Germany, 2Laboratoire Physico-Chimie Fredericksburg, VA 1132 B269 Store-operated TRPC7 Channels Curie, UMR 168 CNRS/Institut Curie, Paris, 1150 B287 Mechanisms and Consequences Function Independently of Stim1 and Orai1. W. France, 3Department of Cell Biology and Howard of Regulation of the cRaf-ERK1/2-Rsk Pathway I. DeHaven, G. S. Bird, J. W. Putney; Laboratory of Hughes Medical Institute, Yale University School of by Osmotic Cell Shrinkage. S. F. Pedersen, M. Signal Transduction, National Institute of Medicine, New Haven, CT Environmental Health Sciences, Research Triangle Rasmussen, H. Klingberg; Molecular Biology, Park, NC 1141 B278 Functional Characterization of University of Copenhagen, Copenhagen, Denmark the Phosphatidylserine Synthase Gene, pps1, in 1151 B288 Overexpression of Phogrin in 1133 B270 Identification of Pathways That the Fission Yeast, Schizosaccharomyces Regulate Steady-State Expression of the Ins-1 Cells: Effects on Insulin Content, and pombe, Reveals Novel Cellular Functions for 1,2 2,3 Voltage-sensitive Potassium Channel Kv1.2 at 1 2 Granule Biogenesis. R. A. Bauer, R. Wong, Phosphatidylserine. Y. Matsuo, E. Fisher, J. S. Hackl,3,2 H. W. Davidson,3,2 J. C. Hutton3,2; the Cell Surface. L. Stirling, A. D. Morielli; 2 S. Marcus1; 1Biological Sciences, Patton-Vogt, 1Cell and Developmental Biology, University of Pharmacology, University of Vermont, Burlington, The University of Alabama, Tuscaloosa, AL, VT 2 Colorado Health Sciences Center, Aurora, CO, Biological Sciences, Duquesne University, 2Barbara Davis Center for Childhood Diabetes, Pittsburgh, PA Aurora, CO, 3University of Colorado Health Structure and Function of Membrane Proteins 1142 B279 An Ultradian Oscillator for the Sciences Center, Aurora, CO 24-hour Biological Clock Based on Protein- 1152 B289 WITHDRAWN 1134 B271 Topologic Structure of bound Copper Hexahydrate. D. Morre,1 Z. Jiang,2 Transmembrane Channel-like Gene 1 Protein D. M. Morre2; 1Medicinal Chemistry and Molecular 1153 B290 Autophagy Extends Lifespan via TMC1. V. Labay, R. M. Weichert, T. Makishima, A. Pharmacology, Purdue University, West Lafayette, Maintaining Homeostasis in Budding J. Griffith; Molecular Biology and Genetics Section, IN, 2Foods and Nutrition, Purdue University, West Yeast Saccharomyces cerevisiae. F. Tang,1 J. Otolaryngology Branch, National Institute on Lafayette, IN Watkins,1 M. Bermudez,1 R. Gray,1 K. Portie,1 A. Deafness and other Communication Disorders, Gaban,1 M. Kleve,1 G. Cracium2; 1Biology, National Institutes of Health, Rockville, MD University of Arkansas at Little Rock, Little Rock, AR, 2Mathematics and Biomolecular Chemistry, University of Wisconsin–Madison, Madison, WI

112 The American Society for Cell Biology 47th Annual Meeting MONDAY December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org Poster Session 2 B291–B320

Protein Folding and Assembly Cell Culture 1174 B312 The Isolation and Characterization of Stem Cells from the Wharton’s Jelly. R. C. Schugar, B. M. Deasy; 1154 B291 WITHDRAWN 1164 B302 Morphological Analyses of University of Pittsburgh, Pittsburgh, PA Close Follicles in the Long Term of Thyroid Pig. 1155 B292 The HIV-1 Envelope 1,2 1 1,3 D. M. Victoria, M. Herrera, A. Ondo, C. M. 1175 B313 Establishment of Insulin- Glycoprotein Signal Sequence Acts as a 1,4 1 Spinel ; Centro Internacional de Física, Bogotá, producing Cell Lines from Embryonic Stem Transient Signal Anchor. Z. Cabartova, M. 2 Colombia, Medicina, Universidad Nacional de Cell-derived Progenitor. G. Li,1 R. Luo,1 F. Xie,1 Lalazarzedeh, E. L. Snapp; Anatomy and Structural 3 Colombia, Bogotá, Colombia, Química, S. Shao,1 S. K. Lim2; 1National University Medical Biology, Albert Einstein College of Medicine, Bronx, Universidad Nacional de Colombia, Bogotá, Institutes, National University of Singapore, NUS, NY 4 Colombia, Biología, Universidad Nacional de Singapore, 2Institute of Medical Biology, A*STAR, Colombia, Bogotá, Colombia 1156 B293 A Polar Residue Mediates TM Singapore Segment Retention within the Sec61 1165 B303 Morphological Analysis of acini 1 1 1 1176 B314 Regulatory Role of Pancreatic Translocon. D. Pitonzo, Z. Yang, K. Rusterholtz, Closed in the Long Term of Submandibular 2,3,4 1 1 Function Using Cultured Cells from A. E. Johnson, W. R. Skach ; Biochemistry & 1,2 1,3 Gland Mouse. D. M. Victoria, L. Cuervo, C. M. Experimental Diabetic Animals. K. A. Hobbs,1 D. Molecular Biology, Oregon Health & Sciences Spinel1,3; 1Centro Internacional de Física, Bogotá, 1 1 1 2 L. Byrd, E. Waddell, J. L. Johnson, J. U. University, Portland, OR, Molecular & Cellular 2 Colombia, Medicina, Universidad Nacional de Johnson,2 A. D. Johnson1; 1Biological Sciences, Medicine, Texas A&M University System Health 3 Colombia, Bogotá, Colombia, Biología, University of Alabama in Huntsville, Huntsville, AL, Science Center, College Station, TX, 3Chemistry, Universidad Nacional de Colombia, Bogotá, 2Food and Animal Science, Alabama A & M Texas A&M University, College Station, TX, Colombia University, Normal, AL 4Biochemistry and Biophysics, Texas A&M University, College Station, TX 1166 B304 A Histological Study of Human 1177 B315 Primary Cultures of the Dental Pulp-derived Odontogenic Cells Cultured Schwann Cells Are Not Homologue between the 1157 B294 Role of the C-terminal, AChE- with Collagen Type I Gel In Vitro. S. Kumabe, M. Dorsal Root Ganglia and the Sciatic Nerve. E. like Domain in Tg Folding and Secretion. J. Nakatsuka, K. Takama, T. Mikami, Y. Iwai; Bernal,1,2 L. Leal,1,3 D. Rojas,1,4 N. Revelo,1,3 C. Lee,1 P. Arvan1,2; 1Program in Cellular and Department of Oral Anatomy, Osaka Dental M. Spinel1,3; 1Centro Internacional de Física, Molecular Biology, University of Michigan, Ann University, Hirakata-shi, Japan Bogota, Colombia, 2Medicina, Universidad Nacional Arbor, MI, 2Department of Internal Medicine, de Colombia, Bogotá, Colombia, 3Biología, University of Michigan, Ann Arbor, MI 1167 B305 Reactive Oxygen Species Universidad Nacional de Colombia, Bogotá, Enhance the Expression of Toll-like Receptors Colombia, 4Universidad Militar Nueva Granada, 1158 B295 The Hsp110 Molecular in THP-1 Cells. Y. Kim, H. Park, J. Seo, S. Yang, Bogotá, Colombia Chaperone Stabilizes Apolipoprotein B from T. Kim, S. Kim, S. Huh, B. Cho, J. Kim; Biological Endoplasmic Reticulum-associated Science, Gachon University of Medicine and 1178 B316 Three-Dimensional Culture Degradation. S. L. Hrizo,1 V. Gusarova,2 D. M. Science, Incheon, Republic of Korea Similar to a Neuronal Prosthesis. E. Bernal,1,2 L. Habiel,2 J. L. Goeckeler,1 E. A. Fisher,2 J. L. Leal,1,3 S. Perdomo,1 C. M. Spinel1,3; 1Centro Brodsky1; 1Department of Biological Sciences, 1168 B306 The Identification of Internacional de Física, Bogota, Colombia, University of Pittsburgh, Pittsburgh, PA, Downstream Signalling Partners to PTHrP in 2Medicina, Universidad Nacional de Colombia, 2Departments of Medicine (Cardiology) and Cell the Mammary Gland. A. Superneau,1 A. Mayer,1 Bogotá, Colombia, 3Biología, Universidad Nacional Biology, New York University, New York, NY M. E. Dunbar,2 D. A. Dunbar1; 1Science, Cabrini de Colombia, Bogotá, Colombia College, Radnor, PA, 2Science, Penn State Berks 1159 B296 Defining the Cellular Response College, Reading, PA 1179 B317 The Third Dimension Fosters to Three "Misfolded Protein" Stresses in Quantitative Cell Biology from Cells to Distinct Cellular Compartments (ER Lumen, 1169 B307 PTHrP Regulates EGFR Organisms. F. Pampaloni,1 M. Marcello,2 E. H. K. Membrane, and Cytosol). M. B. Metzger, S. Activation in the Mammary Gland and in Cell Stelzer1; 1Cell Biology and Biophysics Unit, EMBL Michaelis; Department of Cell Biology, Johns Culture. J. J. Yeager, H. Miller, R. E. Stoica, A. Heidelberg, Heidelberg, Germany, 2Biomedical Hopkins University, Baltimore, MD Getz, M. E. Dunbar; Biology, Penn State Structure Group, German Cancer Research Center University-Berks Campus, Reading, PA 1160 B297 Folding, Assembly, and ER (DKFZ), Heidelberg, Germany Export of Yor1p Mutants, a Yeast ABC 1170 B308 The Increased Expression of the 1180 B318 Spatially Defined, Multiplexed Transporter Homologous to CFTR. S. Pagant, E. Matrix Metalloproteinase-2 Gene by 14-3-3␧ Arrays Supporting Cell Adhesion. J. Johnson, J. Miller; Biological Sciences, Columbia University, Requires the Specific DNA Binding Proteins Adams, M. Pagano, Z. Ge, E. Henderson, S. New York, NY Induced by p38 MAPK Signaling Pathway in Nettikadan; Research, BioForce Nanosciences, NIH3T3 Fibroblast Cells. E. Lee,1 I. Han,1 S. Ames, IA 1161 B298 Interaction Specificity of the Park2; 1Physiology, In Ha Medical School, In Ha Quality Control Ubiquitin Ligase CHIP with 2 University, Incheon, Republic of Korea, Life 1181 B319 Spheroid Formation of Ubiquitin Conjugating Enzymes. Z. Xu, K. Devlin, Science, Sung Kyun Kwan University, Suwon, Mesenchymal Cells on Nanopillar Sheet. T. M. Bold, S. Misra; Molecular Cardiology, Cleveland Republic of Korea Uemura,1 Y. Ohyabu,1 K. Kuwabara,2 A. Miyauchi2; Clinic, Cleveland, OH 1NRI (Nanotechnology Research Institute), AIST 1171 B309 Mechanisms Underlying TNF-␣- (National Institute of Advanced Industrial Science 1162 B299 Identification of 4.1R-based induced cPLA Expression in Human 2 and Technology), Tsukuba, Ibaraki, Japan, Macromolecular Complex in Erythrocyte Rheumatoid Arthritis Synovial Fibroblasts. C. 1 1 1 2Materials Research Laboratories, Hitachi Ltd., Membrane. M. A. Salomao, X. Zhang, Y. Yang, Liu, C. Yang; Pharmacology, Chang Gung 2 1 1 1 Hitachi, Japan J. Chasis, X. An, N. Mohandas ; Red Cell University, Tao-Yuan, Taiwan Physiology Laboratory, New York Blood Center, 1182 B320 Characterization of MSCs New York, NY, 2Life Science Division, University of 1172 B310 Assembly, Fusion, and Isolated from Different Sources and Evaluation California, Lawrence Berkeley National Laboratory, Differentiation of a 3D Skeletal Muscle Model. of Their Cardiomyogenic Potential after Berkeley, CA M. L. Marquette,1 D. Byerly,1 M. A. Sognier2; Exposure to Nitric Oxide Donors. C. L. K. 1NASA Johnson Space Center, Houston, TX, Rebelatto,1 L. Nakao,1 A. Aguiar,2 M. Moretão,2 A. 1163 B300 The Par-3 NTD Adopts a PB1- 2Universities Space Research Association, NASA Senegaglia,1 P. Hansen,1 F. Barchick,1 J. Oliveira,1 like Structure Required for Par-3 Johnson Space Center, Houston, TX Oligomerization and Membrane Localization. W. J. Martins,2 C. Kuligovski,2 A. Christofis,1 D. Feng, H. Wu, L. Chan, M. Zhang; Biochemistry, 1173 B311 Using Cell Volume Distribution Martins,1 P. Shigunov,2 J. Moutinho,1 V. Amaral,1 HKUST, Hong Kong Measurements to Evaluate the Condition of a M. Beltrame,1 M. Olandoski,1 P. Brofman,1 S. Cell Culture. J. T. Elliott,1 M. Halter,1 A. Tona,2 A. Goldenberg,2 A. Dominguez2; 1Culture Cell L. Plant1; 1Cell and Tissue Measurements, National Laboratory, Pontifìcia Universidade Católica do Institute of Standards and Technology, Paraná, Curitiba, Brazil, 2Culture Cell Laboratory, Gaithersburg, MD, 2SAIC, Arlington, VA Instituto de Biologia Molecular do Paraná, Curitiba, Brazil

113 MONDAY The American Society for Cell Biology 47th Annual Meeting Poster Session 2 B321–B349 December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org

1183 B321 Lipid Rafts and Matrix Vesicles 1192 B332 Methods for More Accurate/ 1200 B340 Antibody Delivery to Live Cells. in Osteoblastic Mineralization. S. M. Nielsen- Efficient 3D Reconstruction of Mammalian Cells C. O. Weill, S. Biri, F. Stock, A. Adib, P. Erbacher; Preiss,1 J. M. Gillette2; 1Cell Biology and by Electron Tomography (ET). A. B. Noske,1,2 G. Research and Development, Polyplus-transfection, Neuroscience, Montana State University, Bozeman, P. Morgan,1 B. J. Marsh1,2,3; 1Molecular Cell Illkirch, France MT, 2Cell Biology and Metabolism Branch, National Biology, Institute for Molecular Bioscience, Institutes of Health, NICHD, Bethesda, MD University of Queensland, St. Lucia, Australia, 1201 B341 A Novel Platform for Imaging 2ARC Centre of Excellence in Bioinformatics, and Quantifying Apoptosis in Multiple Non- 1184 B322 Heparin (HP) Augmentation of University of Queensland, Brisbane, Australia, Adherent Cells at a Single Cell Level. Y. S. 1 1 1 Osteoclastic Cell Formation on HL60 Human 3Centre for Microscopy & Microanalysis and School Schiffenbauer, E. Trubniakov, L. Weisz, G. 2 1 2 Promyeloblastic Cells Exposed to 12-O- of Molecular & Microbial Sciences, University of Berke ; Cell Kinetics, Lod, Israel, Department of tetradecanoylphorbol-13-acetate (TPA) and Queensland, St. Lucia, Australia Immunology, Weizmann Institute of Science, 1␣,25-dihydroxyvitamin D3 (VD3). K. Matuoka, K. Rehovot, Israel Sasaki; Faculty of Pharmacy, Chiba Institute of 1193 B333 Development of a Three- Science, Chiba-ken, Japan Dimensional Tissue-on-a-Chip Micro-Organ 1202 B342 Serial Quantification of ROS in Device for Pharmacokinetic Analysis. S. R. Numerous Individual Cells Held on a CellChip. 1 1 1 1185 B323 The Cytotoxic Effects of Five Gonda,1 H. L. Holtorf,2 J. E. Leslie,1 R. Chang,3 J. Y. Schiffenbauer, E. Trubniakov, L. Weisz, G. 2 1 2 Commonly Used Skin Toning (Bleaching) Nam,4 K. Hoeman,5 C. T. Culbertson,5 W. Sun3; Berke ; Cell Kinetics, Lod, Israel, Department of Creams on Allium cepa Root Tip Mitosis. S. C. 1Biotechnology, NASA Johnson Space Center, Immunology, Weizmann Institute of Science, Omeh; Botany, University of Nigeria, Nsukka, Houston, TX, 2Universities Space and Research Rehovot, Israel Nsukka, Nigeria Association, Division of Space Life Sciences, 1203 B343 Coupled Metabolic Reaction on Houston, TX, 3Department of Mechanical 1186 B324 Baicaline Attenuated N-methyl- a Chip: A Step Toward Energy Production on Engineering, Drexel University, Philadelphia, PA, D-aspartate Induced Cytoxicity In Vitro. B. Lee,1 Implantable Medical Devices. C. Mukai,1 M. 4Department of Mechanical Engineering, Drexel D. Hahm,1 H. Lee,1 K. Pyun,2 I. Shim2; Bergkvist,2 J. L. Nelson,1 A. J. Travis1; 1Baker University, Philadelphia, TX, 5Department of 1Acupuncture and Meridianology Scientific Institute for Animal Health, Cornell University, Chemistry, Kansas State University, Manhattan, KS Research Center, Kyung Hee University, Seoul, College of Veterinary Medicine, Ithaca, NY, 2 2 Republic of Korea, Department of Integrative 1194 B334 Engineering Human Embryonic Nanobiotechnology Center, Cornell University, Medicine, College of Medicine, The Catholic Stem Cell Microenvironments. S. Gerecht; Ithaca, NY University of Korea, Seoul, Republic of Korea Chemical and Biomolecular Engineering, Johns 1204 B344 Nonradioactive Quantification of 1187 B325 Effect of Radix Scutellariae on Hopkins University, Baltimore, MD PI3-Kinase Products from Breast Cancer Cell N-methyl-D-aspartate-induced Neurotoxicity in 1195 B335 Human Trabecular Meshwork Lines. K. K. Bruner, P. Neilsen, A. Branch; Echelon 1 1 Rat Cortical Neurons. B. Lee, D. Hahm, H. Cells Up-Regulate Myocilin When Grown on Biosciences, Inc, Salt Lake City, UT 1 2 2 1 Lee, K. Pyun, I. Shim ; Acupuncture and Biomimetic Surfaces. P. Russell, J. Z. Meridianology Scientific Research Center, Kyung 1205 B345 Quantitative Analysis of EGFR Gasiorowski, P. F. Nealey, C. J. Murphy; University Pathway Signalling in Breast Tumors and Hee University, Seoul, Republic of Korea, of Wisconsin–Madison, Madison, WI 2Department of Integrative Medicine, College of Hematopoietic Stem Cells Using a Small 1 2 Medicine, The Catholic University of Korea, Seoul, 1196 B336 UV-Softening Substrates for Volume Immunoassay. E. T. Gentalen, A. Fan, 2 1 1 1 Republic of Korea Spatio-Temporal Mechanotransduction Studies. D. Felsher, P. Vanderhorn, D. Voehringer ; Cell 2 M. T. Frey,1 N. A. Burnham,2 Y. Wang1; Biosciences, Palo Alto, CA, Stanford University, 1188 B326 Isolation of Cardiomyocytes and 1Physiology, University of Massachusetts Medical Stanford, CA Endothelial Cells from Mouse Ventricles. S. E. School, Worcester, MA, 2Physics, Worcester 1 1 1 2 1206 B346 Multiplexed Detection of Cellular Kendall, X. Cheng, K. Mohan, S. Sheridan, C. Polytechnic Institute, Worcester, MA Phil,2 R. Kovelman,1 V. Chu1; 1Millipore Biomarkers Using Multispectral Imaging. P. M. Corporation, Temecula, CA, 2Millipore Corporation, 1197 B337 Efficient Delivery of Antibody Kasili, D. T. Lynch, J. R. Mansfield, R. M. Danvers, MA into Living Cells Using a Novel HVJ Envelope Levenson; Life Sciences, Cambridge Research & Vector System. Y. Kondo,1 K. Miyata,2 K. Instrumentation, Woburn, MA 1189 B327 A Novel, Serum-free and Animal 1 T. Fujieda,1 K. Sakai,1 F. Kato,1 M. Fushikida, 1207 B347 Nanopipette Probe Component-free Culture Medium for the Kato,1 Y. Kaneda3; 1Medicinal Research Propagation and Maintenance of Human Functionalization for Single-Cell Biosensing. S. Laboratory, Central Research Institute, Ishihara 1 1 1,2 1 Embryonic Stem Cells. J. Johnson, H. 2 Umehara, M. Karhanek, N. Pourmand ; Sangyo Kaisha Ltd., Kusatsu, Japan, Life Science 1 Bradburn,2 D. Crombie,1 J. Greenhalgh,1 R. Stanford Genome Technology Center, Stanford Technology Development Division, R/D Strategy 2 3 3 1 4 University, Palo Alto, CA, Biomolecular Mondeh, N. Emre, C. O'Brien, R. Malavarca, R. Headquarters, Ishihara Sangyo Kaisha Ltd., Osaka, 3 2 1 3 Engineering, University of California, Santa Cruz, Kovelman, J. Mee, P. Bello, M. A. Singer ; Japan, 3Gene Therapy Science, Graduate School 1 2 Santa Cruz, CA Stem Cell Sciences, Melbourne, Australia, Stem of Medicine, Osaka University, Osaka, Japan Cell Sciences, Edinburgh, United Kingdom, 1208 B348 A Novel Microfluidic System for 3Millipore, Temecula, CA, 4Millipore, Bedford, MA 1198 B338 Generation of Stably Single Cell Shear Stress Experimentation. J. Transfected Cell Clones from Hard-to-Transfect 1 1 1,2 1 1190 B328 Three-Dimensional Cell Culture Wang, M. Tsuzaki, J. Qi, M. E. Wall, R. Cell Lines. M. Stosik, C. Thiel, F. Braasch, S. Sumanasinghe,1 A. J. Banes1,2; 1Flexcell Models for Assessing Anti-Tumor Activity In Carsten, J. Domke, N. Faust; Research and Vitro. B. J. Howell,1 E. Walsh,1 E. Keough,1 S. International Corporation, Hillsborough, NC, Development, amaxa AG, Koeln, Germany 2 Krotzer,1 M. Cerra,1 J. Watters,2 R. Phillips,2 L. Biomedical Engineering, North Carolina State Sepp-Lorenzino1; 1RNA Therapeutics, Merck & Co, 1199 B339 Gene Transfer Agent, a New University/University of North Carolina, Raleigh and West Point, PA, 2Molecular Profiling, Merck & Co, Molecular NanoScaffold for Targetable Drug Chapel Hill, NC West Point, PA Delivery. A. Spano,1 F. S. Chen,1 K. Blasier,1 B. 2 3 3 1209 B349 Enzyme Metallography Silver Goodman, M. N. Simon, J. S. Wall, J. J. 1 1 4 5 5 Deposition for HRP Detection. W. Liu, D. Mitra, Correia, W. W. Newcomb, J. C. Brown, J. M. 1 2 2 1 New and Emerging Technologies for Cell 6 6 1 R. Powell, R. Tubbs, J. Pettay, J. Hainfeld ; Schnur, N. Lebedev ; Biology, University of 1Nanoprobes, Incorporated, Yaphank, NY, Biology II Virginia, Charlottesville, VA, 2Graduate Program in 2Department of Anatomic and Clinic Pathology, Cell and Molecular Biology, Johns Hopkins Cleveland Clinic Foundation and the Cleveland University, Baltimore, MD, 3Biology, Brookhaven 1191 B331 Modifiable Hydrogel Reagents Clinic Lerner College of Medicine of Case Western National Laboratory, Upton, NY, 4Department of for 3D Cell Culture. B. M. Angres, K. Benz, S. Reserve University, Cleveland, OH Sturany, D. Stoll, B. Platz, H. Wurst; NMI Natural Biochemistry, University of Mississippi Medical and Medical Sciences Institute at the University of Center, Jackson, MS, 5Department of Microbiology Tuebingen, Reutlingen, Germany and Cancer Center, University of Virginia Health System, Charlottesville, VA, 6Center for Bio- Molecular Sciences & Engineering, U.S. Naval Research Laboratory, Washington, DC

114 The American Society for Cell Biology 47th Annual Meeting MONDAY December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org Poster Session 2 B350–B383

Biological Computing and Modeling 1221 B362 Excessive Oxidative Stress 1232 B373 Using Genomic DNA as the Impairs Steroidogenesis through Modulation of Normalizer for QRT-PCR Analysis: Gene StAR Gene Expression: Evidence for Expression Comparison in Human Liver Cells 1210 B350 Modeling Arf1 Dynamics in Involvement of p38 MAPK. S. K. Zaidi,1 P. Abidi,1 Producing Normal or Mutant Alpha 1- Coxsackievirus-infected Cells. A. Chintalapani,1 Y. Cortez,1 S. Leers-Sucheta,1 M. McLean,2 W. Antitrypsin. N. Novoradovskaya,1 F. N. Rouhani,2 M. Hanna,1 N. Altan-Bonnet2; 1Mathematical Shen,1 S. Azhar1; 1GRECC, VA Palo Alto Health S. Basehore,1 A. Novoradovsky,3 M. Brantly,2 J. Biology, New Jersey Institute of Technology, CARE System and Stanford School of Medicine, Braman1; 1Research and Development, Stratagene, Newark, NJ, 2Biological Sciences, Rutgers Palo Alto, CA, 2Departments of Obstetrics & An Agilent Technologies Co., La Jolla, CA, University, Newark, NJ Gynecology, and Biochemistry and Molecular 2University of Florida, Gainesville, FL, 3Decisive 1211 B351 StarNet: Visual Data Mining for Biology, University of South Florida, Tampa, FL Diagnostics, Jackson, WY Inferring Gene Regulatory Networks in Mouse 1222 B363 Neurotrophin-4 Involvement in Cardiac Development. D. Jupiter, V. VanBuren; Skin Melanogenesis and Its Control. K. Lazou, Chromatin Remodeling Systems Biology, Texas A & M Health Science C. Marteau, M. Dumas, J. Archambault, R. Center, Temple, TX Kurfürst, F. Bonte, E. Perrier; LVMH Recherche, St 1233 B374 Embryonic Stem Cell DNA 1212 B352 Studying Cellular Processes at Jean de Braye, France Methylation Modulates the Interaction of Network Level: A Systems Biology Approach. Nucleosome-binding Proteins with Chromatin. 1223 B364 Pigment Epithelial-derived A. Mithani,1 A. Rico,2 R. Jones,2 G. M. Preston,2 J. E. Rand,1 E. Meshorer,2 M. Bustin1; 1Laboratory of Factor (PDEF) Is a Novel Transcriptional Target Hein1; 1Department of Statistics, University of Metabolism, NIH/NCI, Bethesda, MD, 2Department of the Nuclear Receptor Corepressor (NCoR) in Oxford, Oxford, United Kingdom, 2Department of of Genetics, Hebrew University, Jerusalem, Israel Intestinal Epithelial Cells. G. Doyon, C. Asselin, Plant Sciences, University of Oxford, Oxford, F. Boudreau; Anatomy and Cell Biology, Universite United Kingdom 1234 B375 Live Cell Analysis of DNA de Sherbrooke, Sherbrooke, PQ, Canada Demethylation during Transcriptional Activation 1213 B353 Diffusion-controlled Reaction in Mammalian Cells. S. Powers,1 L. Joo,1 I. 1224 B365 Tissue Specific Expression of Kinetics in the Trap Hierarchy Model. M. J. Rafalska-Metcalf,1 A. Yasui,2 S. Janicki1; 1Wistar Cdh23 Isoforms during Development of the Saxton; Biochemistry and Moelcular Medicine, Institute, Philadelphia, PA, 2Department of Mouse Inner Ear and Retina. A. Lagziel,1 N. University of California, Davis, Davis, CA Molecular Genetics, Institute of Development, Overlack,2 U. Wulfrum,2 T. B. Friedman,1 R. J. Aging, and Cancer, Tohoku University, Sendai, Morell1; 1Laboratory of Molecular Genetics, 1214 B354 WITHDRAWN Japan National Institute on Deafness and Other 1215 B355 WITHDRAWN Communication Disorders National Institute of 1235 B376 Poly (ADP-ribose) Polymerase 1 Health, Rockville, MD, 2Institute of Zoology Cell 1216 B356 Development and Validation of Controls Protein Shuttling into Cajal Body. M. and Matrix Biology, Johannes Gutenberg University Functional Gene Regulatory Network Models. T. Jarnik, E. Kotova, A. V. Tulin; Fox Chase Cancer of Mainz, Mainz, Germany L. Andersen, L. Zhu, T. Otter; Crowley Davis Center, Philadelphia, PA Research, Eagle, ID 1225 B366 Differentiation of Rat Bone 1236 B377 Analysis of the Function of the Marrow Stromal Cells (RBMSCs) under NAP1-Family Member Vps75p. K. M. Keck,1 H. A. Tissue-specific Gene Expression Capsaicin Stimuli. F. Aikawa, Y. Iwai; Oral Montgomery,2 D. F. Hunt,2 L. F. Pemberton1; Anatomy, Osaka Dental University, Hirakata-shi, 1Center for Cell Signaling/Microbiology, University Japan of Virginia, Charlottesville, VA, 2Chemistry, 1217 B358 The Homeodomain Transcription University of Virginia, Charlottesville, VA Factor Cdx2 Regulates Desmocollin 2 Gene 1226 B367 Role of Praja in Zebrafish Expression in Colon Cancer Cells. S. Funakoshi; Development. A. Tiwari,1 V. Mishra,1 E. Glasgow2; 1237 B378 The Role of PLC and the Gastroenterology, University of Pennsylvania, 1Biology, Sidwell Friends School, Washington, DC, Inositol Polyphosphates in Chromatin Philadelphia, PA 2Georgetown University, Washington, DC Structure. J. Chang, A. Vancura; Biological Sciences, St. John's University, Queens, NY 1218 B359 Increased Retinoid Signaling in 1227 B368 Turkish Allele Frequencies at Rat HSCs Activated In Vitro by Post- Five X-chromosomal STR Loci. F. Asıcıoglu,1 F. 1238 B379 Bifunction of C/EBP␤ and transcriptional Up-Regulation of RAR␣ Gene Akyuz,1 F. Oguz,2 K. Ozdilli,3,2 M. Carin2; 1The HDAC4 Modulated Transcriptional Regulation of Expression. Y. Mezaki,1 K. Yoshikawa,1 N. Council of Forensic Medicine, Istanbul, Turkey, COX2 Gene. W. Wang; Institute of Basic Medical Yamaguchi,1 M. Miura,1 K. Imai,1 S. Kato,2 H. 2Istanbul University, Istanbul, Turkey, 3Halic Sciences, Department of Pharmacology, National Senoo1; 1Anatomy, Akita University School of University, Istanbul, Turkey Cheng Kung University, Tainan, Taiwan Medicine, Akita, Japan, 2Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1228 B369 Transgenic Mice Expressing 1239 B380 PGC1␣ Induces Chromatin Tokyo, Japan Progerin in the Skin. Y. Wang, H. Worman; Structure Changes at the MHRE Region of the Department of Medicine and Anatomy and Cell ERR␣ Gene. L. Wang, P. Hu, C. T. Teng; National 1219 B360 Expression of Polymorphic Free Biology, Columbia University, New York, NY Institute of Environmental Health Sciences, HLA Class I Heavy Chains by Male Research Triangle Park, NC Gametogenic Cells in the Human Testis. H. 1229 B370 Effect of Fine Particle on the Hutter,1 M. Siwetz,1 A. Blaschitz,1 H. Trummer,2 A. DNA Damage and Tenascin-C Expression in 1240 B381 Direct Interactions between Ziegler,3 B. Uchanska-Ziegler,3 G. Dohr1; 1Institute C56BL7 Mice Lung In Vivo. S. Kim, M. Kim, H. SRG3 and the Major Components of the SWI/ of Cell Biology, Histology and Embryology, Medical Lee, D. Kim, Y. Hwang; Division of Biological SNF Chromatin Remodeling Complex Stabilize University of Graz, Center for Molecular Medicine, Science, Gachon University of Medicine & Science, Them against Proteasomal Degradation. D. H. Graz, Austria, 2Department of Urology, Medical Incheon, Republic of Korea Sohn, H. Yoon, C. Lee, J. Oh, R. H. Seong; 3 Department of Biological Sciences, Institute of University of Graz, Graz, Austria, Institute of 1230 B371 Mechanical Cues from the Molecular Biology and Genetics, Seoul National Immunogenetics, Charite, Humbold University of Extracellular Matrix Modulate Tissue-specific University, Seoul, Republic of Korea Berlin, Berlin, Germany Gene Transcription. J. Alcaraz,1 R. Xu,1 H. Mori,1 2,3 1 1 1220 B361 Attenuation of Osteoblast C. Bustamante, M. J. Bissell ; Cell and 1241 B382 Evidence for Paternal Allele- Growth and Differentiation by Helix-Loop-Helix Molecular Biology, Lawrence Berkeley National specific Chromatin Extension and Looping of 2 (HLH) Protein-dependent Gene Regulatory Laboratory, Berkeley, CA, Physics, University of the SNRPN to UBE3A Locus in Mature Neurons 3 Pathways. Y. Zhang, M. Q. Hassan, J. L. Stein, J. California at Berkeley, Berkeley, CA, Howard by Fluorescence In Situ Hybridization. K. N. B. Lian, A. J. van Wijnen, G. S. Stein; Department Hughes Medical Institute, Berkeley, CA Thatcher, R. O. Vallero, B. J. Woods, J. M. LaSalle; University of California, Davis, Davis, CA of Cell Biology and Cancer Center, University of 1231 B372 Tissue-specific and Massachusetts Medical School, Worcester, MA Developmental Expression of CMG2, a Gene 1242 B383 Human Rvb1/Tip49 Promotes Implicated in Neo-Angiogenesis. M. Vargas; PhosphoH2AX Downregulation through the Biology, University of Texas at San Antonio, San Regulation of Tip60 Acetyltransferase Complex. Antonio, TX S. Jha, E. Shibata, A. Dutta; Biochemistry, University of Virginia, Charlottesville, VA

115 MONDAY The American Society for Cell Biology 47th Annual Meeting Poster Session 2 B384–B414 December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org

1243 B384 Restriction Enzyme Analysis of 1254 B395 Treatment with 1263 B405 Deficient Activity-dependent DNA Methylation in Chromatin of 17-beta- Farnesyltransferase Inhibitors Causes Donut- mRNA Transport in a Mouse Model of Fragile X Estradiol-transformed MCF-10F Cells. M. S. shaped Nuclei. V. L. R. Verstraeten,1,2 L. A. Syndrome. J. B. Dictenberg,1 L. Antar,2 R. H. MELLO,1 P. Russo,2 J. Russo,2 B. C. Vidal1; 1Dept Peckham,1 C. L. Stewart,3 L. G. Fong,4 S. G. Singer,3 G. J. Bassell4; 1Biological Sciences, of Cell Biology, UNICAMP/IB, Campinas, Brazil, Young,4 J. Lammerding1; 1Cardiovascular Division, Hunter College of the City University of New York, 2Breast Cancer Research Laboratory, Fox Chase Brigham and Women’s Hospital, Cambridge, MA, New York, NY, 2Neuroscience, Albert Einstein Cancer Center, Philadelphia, PA 2Department of Dermatology, University Hospital College of Medicine, Bronx, NY, 3Anatomy and Maastricht, Maastricht, The Netherlands, 3Institute Structural Biology, Albert Einstein College of 1244 B385 Unique and Overlapping of Medical Biology, Proteos, Singapore, Medicine, Bronx, NY, 4Cell Biology and Neurology, Developmental Roles of UNC-85 and ASFL-1, 4Department of Medicine, David Geffen School of Emory University, Atlanta, GA Two C. elegans Homologs of the Histone Medicine, University of California, Los Angeles, CA Chaperone Asf1. I. F. Grigsby, F. P. Finger; 1264 B406 A Pre-synaptic Chaperone Biology Department and Center for Biotechnology 1255 B396 Characterisation of Nuclear Complex That Stabilizes SNAP-25. M. Sharma, P. and Interdisciplinary Studies, Rensselaer Lamin Binding to the Nuclear Pore Protein Bronk, G. Gallardo, T. Sudhof; Department of Polytechnic Institute, Troy, NY Nup153. T. Al-Haboubi,1 D. K. Shumaker,2 U. Neuroscience, UT Southwestern Medical Center, Aebi,1 R. D. Goldman,2 B. Fahrenkrog1; 1MIH- Dallas, TX Structural Biology, M.E. Mueller Institute for Nuclear Envelope and Lamina Structural Biology, Biozentrum, University of Basel, 1265 B407 Inhibition of Tyrosine Kinase Basel, Switzerland, 2Cell and Molecular Biology, Activity Induces the Appearance of Axons and 1245 B386 Yeast Nuclear Architecture and Northwestern University Feinberg School of Sodium Currents in PC12 Cells. M. V. Longart, L. the Regulation of Nuclear Function. K. L. Medicine, Chicago, IL L. Garcia, C. Castillo, J. C. Martinez, P. Forsyth, R. Witkin,1 J. L. Campbell,1 S. Jaspersen,2 O. Cohen- Medina, C. Malave; Centro de Biociencias y Fix1; 1LMCB, NIDDK, NIH, Bethesda, MD, 1256 B397 Nup155, a Conserved Medicina Molecular, Institutos de Estudios 2Stowers Institute for Medical Research, Kansas Nucleoporin Is Located in Both the Macro- and Avanzados, Caracas, Venezuela City, MO Micronuclear Envelope of a Ciliate Tetrahymena thermophila. M. Iwamoto,1 F. Bunai,1 T. Kojidani,1 1266 B408 Adenomatous Polyposis Coli 1246 B387 What Keeps the Yeast Nucleus H. Osakada,1 A. Yamamoto,2 Y. Hiraoka,1 T. Reduces the Lateral Mobility of Nicotinic Hanging ‘Round?: Methods to Identify Genes Haraguchi1; 1CREST Research Project, Kansai Acetylcholine Receptors on the Cell Surface. Y. That Maintain Nuclear Structure in S. Advanced Research Center, Kobe, Japan, Yao, Z. Wang; Department of Cell and cerevisiae. M. T. Webster; NIDDK, NIH/Johns 2Nagahama-Bio University, Nagahama, Japan Neurobiology, University of Southern California Hopkins University, Bethesda, MD School of Medicine, Los Angeles, CA 1257 B398 Long-term Stability of Nuclear 1247 B388 Stages of Karyogamy in Yeast. Pore Complexes in Differentiated Cells. M. A. 1267 B409 SynGAP Regulates NMDA A. M. Tartakoff; Pathology, Case Western Reserve D'Angelo, M. W. Hetzer; Molecular and Cell Biology Receptor-dependent Cofilin Activity. H. J. University, Cleveland, OH Laboratory, Salk Institute for Biological Studies, La Carlisle, M. B. Kennedy; Biology, California Institute Jolla, CA of Technology, Pasadena, CA 1248 B389 Genetic Analyses Reveal Tissue-specific Contributions of the Drosophila 1258 B399 Reshaping Endoplasmic 1268 B410 The Arf GAP Centaurin Alpha-1 LEM Domain Proteins in the Nuclear Lamina. B. Reticulum on Chromatin during Nuclear Modulates Neuronal Differentiation through the Pinto,1 S. R. Wilmington,2 E. E. L. Hornick,2 L. L. Envelope Assembly. D. J. Anderson, J. P. Hsiao, Regulation of Arf6. C. D. Moore, S. Worth, D. Hill, Wallrath,2 P. K. Geyer2; 1Molecular and Cellular M. W. Hetzer; The Salk Institute for Biological J. Larimore, C. Chapleau, L. Pozzo-Miller, A. Biology, University of Iowa, Iowa City, IA, Studies, La Jolla, CA Theibert; Neurobiology, University of Alabama at 2Biochemistry, University of Iowa, Iowa City, IA Birmingham, Birmingham, AL 1249 B390 Phosphorylation Regulates Synapse Formation and Function 1269 B411 Actin Contractility and Bundling Barrier-to-Autointegration Factor (BAF) Mediate Dendritic Spine Genesis and Synapse 1 Formation in Hippocampal Neurons. M. Vicente- Function during Nuclear Assembly. J. Lei, M. 1259 B401 Role of GABP␣ Phosphorylation 2 3 3 2 Manzanares, H. Asmussen, A. F. Horwitz; Cell Wiebe, L. O’Brien, C. Wiese, P. Traktman, M. in Neuregulin-1-Induced Acetylcholine Receptor 1 1 Biology, University of Virginia, Charlottesville, VA Segura-Totten ; Biology, The College of New Transcription. L. Fromm, C. A. Herndon; Indiana Jersey, Ewing, NJ, 2Microbiology and Molecular University School of Medicine–Muncie and Ball 1270 B412 Characterization of Paralemmin- Genetics, Medical College of Wisconsin, State University, Muncie, IN 3, a New Isoform of the Paralemmin Protein Milwaukee, WI, 3Biochemistry, University of Family Implicated in Membrane Dynamics. G. Wisconsin–Madison, Madison, WI 1260 B402 Development of Cerebellar Hultqvist, N. G. Neumann, M. W. Kilimann; ICM, Stellate and Basket Cells in GAD65-eGFP Mice. Uppsala Universitet, Uppsala, Sweden 1250 B391 Regulation of Emerin by M. I. Davis, A. T. Hassoun; Section on Synaptic Tyrosine Phosphorylation. K. E. Tifft, K. L. Pharmacology, NIH/NIAAA, Bethesda, MD 1271 B413 Molecular Determinants of Wilson; Cell Biology, Johns Hopkins, Baltimore, MD BDNF/TrkB Trafficking and Signaling. K. 1261 B403 The Rab5 Guanylate Exchange Deinhardt, M. V. Chao; Molecular Neurobiology, 1251 B392 Effect of the EDMD-causing Factor Rin1 Links Internalization of Activated Skirball Institute, New York University School of R453W Mutation on Stability of the C-terminal EphA4 to Synaptic Plasticity. K. M. Deininger,1 1 1 Medicine, New York, NY Lamin A/C IG Fold. J. Pajerowski, F. L. Zhong, M. Eder,2 W. Zieglgänsberger,2 J. Colicelli,3 H. 2 1 D. E. Discher ; Bioengineering, University of 2 1 Dodt ; Molecular Neurobiology, Max Planck 1272 B414 Essential Role of CIT-N in Pennsylvania, Philadelphia, PA, 2Chemical and Institute of Neurobiology, Martinsried-Munich, Dendritic Spine Maturation through Actin Biomolecular Engineering, University of 2 Germany, Max Planck Institute of Psychiatry, Remodeling on Spine-associated Golgi Pennsylvania, Philadelphia, PA 3 Munich, Germany, Department of Biological Compartments. P. Camera,1 V. Schubert,2 G. 1252 B393 TorsinA Maintains Nesprin-2G in Chemistry, University of California, Los Angeles Berto,1 Y. Bosio,1 A. Vercelli,3 C. Dotti,4 F. Di the Nuclear Envelope to Allow for Nuclear School of Medicine, Los Angeles, CA Cunto1; 1MBC, University of Torino, Torino, Italy, 2Fondazione Cavalieri Ottolenghi, Torino, Italy, Movement and Centrosome Polarization in 1262 B404 Rab21 Regulates Anterograde 1 2 3Department of Anatomy, Pharmacology and Migrating Cells. G. W. G. Luxton, W. T. Dauer, Transport of TI-VAMP Vesicles in Growing 1 1 Forensic Medicine, University of Torino, Torino, G. G. Gundersen ; Anatomy & Cell Biology and Neurites. T. Galli,1 E. Sotirakis,1 A. Burgo,1 C. Italy, 4Department of Human Genetics, Catholic Pathology, Columbia University, New York City, NY, Chamot,2 L. Lanzetti3; 1INSERM Avenir Team 2 University of Leuven and Flanders, Leuven, Neurology and Pharmacology, Columbia 'Membrane Trafficking and Neuronal & Epithelial Belgium University, New York City, NY Morphogenesis', Institut Jacques Monod, Paris, France, 2Imaging Platform, Institut Jacques Monod, 1253 B394 Lmo7 Directly Activates Muscle 3 Differentiation Genes, is Inhibited by Emerin- Paris, France, Department of Oncological binding, and Regulates C2C12 Myoblast Sciences, Institute for Cancer Research and Treatment, University of Torino, Torino, Italy Differentiation. J. M. Holaska; Medicine/Section of Cardiology, University of Chicago, Chicago, IL

116 The American Society for Cell Biology 47th Annual Meeting MONDAY December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org Poster Session 2 B415–B448

1273 B415 NCAM Regulates Trafficking of 1284 B427 Cytoskeleton-dependent 1294 B437 Effect of Oxidative and NMDA Receptors. V. Sytnyk,1 I. Leshchyns'ka,1 M. Mitochondrial Remodeling in Osmotic Stress. Nitrosative Stress on Mitochondrial Aconitase Schachner1,2; 1Institute for Biosynthesis of M. Zulys,1,2,3 T. Yeung,4,3 A. Kapus1,2,3; 1St. Activity in Rat Kidney during Diabetes Mellitus. Neuronal Structures, Center for Molecular Michael's Hospital Research Institute, Toronto, ON, R. V. Pérez-Gallardo, S. Albarrán-Bravo, J. L. Neurobiology, Hamburg, Germany, 2Keck Center Canada, 2Department of Surgery, University of Ayala-Izquierdo, M. Clemente-Guerrero, S. Manzo- for Collaborative Neuroscience and Department of Toronto, Toronto, ON, Canada, 3Institute of Medical Avalos, A. Saavedra-Molina; Inst. Invest. Quimico- Cell Biology and Neuroscience, Rutgers University, Science, University of Toronto, Toronto, ON, Biologicas, Universidad Michoacana, Morelia, Piscataway, NJ Canada, 4Division of Cell Biology, Hospital for Sick Mich., Mexico Children, Toronto, ON, Canada 1274 B416 Regulation of Neuronal 1295 B438 Reversing Endosymbiosis of Development by Rac GTPases. S. Corbetta, S. 1285 B428 Haplotypic Analyses of Human Mitochondria. M. Leguia, A. Vila-Sanjurjo, B. Gualdoni, G. Ciceri, I. de Curtis; San Raffaele Mitochondrial DNA Hypervariable Segments Zamft, A. Rosenbloom, F. Stroehle, C. Bustamante; Scientific Institute, Milano, Italy Reveal Regional Variation in Haiti. J. L. University of California, Berkeley, Berkeley, CA Wilson,1,2 B. Ely,3 J. O. Auguste,2 B. A. Jackson1,2; 1275 B417 Syntabulin-KIF5B-mediated 1Biomedical Engineering and Biotechnology 1296 B439 Measurement of NAD(P)H and Axonal Transport Contributes to Activity- Program, University of Massachusetts, Lowell, MA, Flavoprotein Autofluorescence in Intact dependent Presynaptic Assembly. Q. Cai, P. 2Biotechnology and Forensic DNA Science Cardiomyocyte to Determine Effects of Pan, Z. Sheng; NIH/NINDS/SFU, Bethesda, MD Program, MassBay Community College, Wellesley, Isoflurane on Mitochondrial Bioenergetics. F. 1,2 2 2 MA, 3Department of Biological Sciences, University Sedlic, K. C. Vinnakota, T. Wakatsuki, M. 1276 B418 Functional Consequences of 1 1,2 1 of South Carolina, Columbia, SC Bienengraeber, Z. Bosnjak ; Anesthesiology, Developmental Myosin II Downregulation in Medical College of Wisconsin, Milwaukee, WI, Sensory Neurons. S. L. Jones, A. R. Ketschek, G. 1286 B429 Molecular Dynamics Perspective 2Physiology, Medical College of Wisconsin, Gallo; Neurobiology and Anatomy, Drexel of Cellular Autofluorescence: From Single-Cell Milwaukee, WI University College of Medicine, Philadelphia, PA to Neural Network in Brain Slices. A. A. Heikal; Bioengineering, Pennsylvania State University, 1297 B440 Mitochondrial “Surfing”: A 1277 B419 Knockdown of Synaptotagmin University Park, PA Novel Form of Cytoskeleton-independent by RNAi Alters Neurite Outgrowth in Neonatal Peroxisomal Motility in Fission Yeast. I. Sympathetic Neurons In Vitro. K. F. Greif, F. 1287 B430 Identification of Signaling Jourdain, D. Sontam, C. Johnson, C. Dillies, J. Badiane, K. Krasnec, S. Chan, N. Asabere, R. Components That Regulate Mitochondrial Hyams; IMBS, Massey University, Palmerston Jackson; Biology, Bryn Mawr College, Bryn Mawr, Morphology in High Glucose Stimulation. T. Yu, North, New Zealand PA J. Sheu, R. J. Fox, Y. Yoon; Department of Anesthesiology, University of Rochester, Rochester, Signal Transduction in Development II Chloroplasts and Mitochondria NY 1288 B431 Roles of Mss51 in Assembly 1298 B442 Protein-O-fucosyltransferase 1 1278 B421 Reversible Phosphorylation of Feedback Control of Cox1 Synthesis in S. Regulates Nodal Signaling during Early Dynamin-related Protein 1 by PKA and cerevisiae Mitochondria. X. Perez-Martinez,1 Z. Xenopus Embryogenesis. Y. Kim, J. An, C. Yeo; Calcineurin Controls Mitochondrial Morphology W. Via,2 C. A. Butler,2 T. D. Fox2; 1Departamento Division of Life and Pharmaceutical Sciences, and Cell Death. J. T. Cribbs, A. M. Slupe, S. de Bioquimica, Instituto de Fisiologia Celular, Ewha Womans University, Seoul, Republic of Strack; Pharmacology, University of Iowa, Iowa UNAM, Ciudad Universitaria, Mexico DF, Mexico, Korea City, IA 2Department of Molecular Biology & Genetics, Cornell University, Ithaca, NY 1299 B443 Notch Signaling Controls Lateral 1279 B422 Regulation of Mitofusin-2 by Line Development in Zebrafish. M. Itoh, M. 1 1 Protein Kinase A. S. K. Nifoussi, J. T. Cribbs, M. 1289 B432 De-synchronization of Inner and Isoda, M. Tsutsumi; IAR, Nagoya University, 2 2 1 1 Cleland, R. Youle, S. Strack ; Department of Outer Mitochondria Dynamics as a Protection Nagoya, Japan Pharmacology, University of Iowa, Iowa City, IA, Mechanism against Cell Death in Yeast. F. F. 2SNB, NINDS, NIH, Bethesda, MD Severin, S. Sokolov, D. Knorre, L. Bakeeva, V. 1300 B444 A Role for Zebrafish Fatty Acid Saprunova, S. Ozhovan; Bioenergetics, A.N. Transport Protein 2A in Primitive 1280 B423 Cytoskeletal Asymmetry 1,2 1 Belozersky Institute of Physico-Chemical Biology, Erythropoiesis. R. L. Miyares, S. A. Farber ; Influences Eyespot Localization in 1Embryology, Carnegie Institution of Washington, 1 Moscow, Russian Federation Chlamydomonas reinhardtii. T. M. Mittelmeier, Baltimore, MD, 2Biology, Johns Hopkins University, 2 1 1 M. Lamb, D. T. Sund, C. L. Dieckmann ; 1290 B433 Identification of Short Peptide Baltimore, MD 1Biochemistry and Molecular Biophysics, University Sequences Binding to the Mitochondrial Fission of Arizona, Tucson, AZ, 2Biology, University of Protein hFis1. M. N. Serasinghe,1 Y. Yoon2; 1301 B445 The scube Gene Family in Puget Sound, Tacoma, WA 1Biochemistry and Biophysics, University of Hedgehog Signalling and Slow Muscle Rochester, Rochester, NY, 2Anesthesiology, Development. J. F. Johnson,1 G. E. Hollway,1 P. 1281 B424 Effects of Pyruvate on 2 1 1 University of Rochester, Rochester, NY Gautier, P. D. Currie ; Developmental Biology, Mitochondrial Functions Following Ischemia Victor Chang Cardiac Research Institute, Sydney, 1 1 and Reperfusion Injury. P. Sharma, S. Rotolo, 1291 B434 Accumulation of an Active Australia, 2Human Genetics Unit, MRC, Edinburgh, 1 2 1 P. D. Mongan, R. Bünger ; Anesthesiology, Metabolite of AZT, AZT-triphosphate, Induces United Kingdom Uniformed Services University of the Health Apoptosis of Juckat Cells by Caspase-3 Sciences, Bethesda, MD, 2Anatomy, Physiology Activation. T. Sato, J. Sukegawa, T. Yanagisawa; 1302 B446 A Dominant-Negative Approach and Genetics, Uniformed Services University of the Molecular Pharmacology, Graduate School of to Investigate the Complexity of Vertebrate G- Health Sciences, Bethesda, MD Medicine, Tohoku University, Sendai, Japan Protein Signaling in Primordial Germ Cell Migration. T. Mulligan, S. Farber; Embryology, 1282 B425 The Dynamin-related Protein 1292 B435 Mitochondrial Heterogeneity in Carnegie Institution of Washington, Baltimore, MD Dnm1 Couples Mitochondrial Organization to Paramecium. W. E. Bell,1 E. Kamura,1 R. Microtubules in the Cell Cycle of Fission Yeast. Hallworth2; 1Department of Biology, Virginia Military 1303 B447 Control of Nanog and Cdx2 I. Jourdain,1 C. Johnson,1 Y. Gachet,2 J. Hyams1; Institute, Lexington, VA, 2Department of Biomedical Expression in the Inner Cell Mass vs. 1IMBS, Massey University, Palmerston North, New Sciences, Creighton University, Omaha, NE Trophectoderm Decision. J. Unternaehrer, L. Zealand, 2Université Paul Sabatier, Toulouse, Chen, C. Lu, G. Daley; Hematology/Oncology, France 1293 B436 Cardiolipin Has a pK2 Above 8.0 Children's Hospital Boston, Boston, MA Only in Bilayers: Implication for Barth’s 1283 B426 Overexpression of dmrs a Syndrome & ATP Synthesis. T. H. Haines; 1304 B448 TGF-␤3 Inhibits Chondrogenesis Drosophila Mitochondrial Transporter Results in Biochemistry and Molecular Biology, Rockefeller of Cultured Chick Leg Bud Mesenchymal Cells Disruption of Normal Iron Homeostasis in the University, New York, NY via Down-Regulation of Connexin 43 and Drosophila Cell Line l(2)mbn. C. Metzendorf, W. Integrin ␤4. D. Kim, Y. Choi, H. Kang, E. Jin, S. Wu, M. Lind; Comparative Physiology, Uppsala Kang; Biological Sciences, Kyungpook National University, Uppsala, Sweden University, Daegu, Republic of Korea

117 MONDAY The American Society for Cell Biology 47th Annual Meeting Poster Session 2 B449–B478 December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org

1305 B449 Identification of Timeless as a 1315 B460 GFP Transfection and Electron Host-Bacterial Pathogen Interactions Src-family Kinase SH3-binding Protein and Tomography Reveal Trafficking Ultrastructure in Substrate in Murine ES Cells. L. P. O'Reilly, T. E. Malaria Parasite-infected Erythrocytes. L. Tilley,1 1324 B469 Pleotropic Action of Smithgall; Molecular Genetics and Biochemistry, E. Hanssen,1 K. Jackson,1 R. Sougrat,2 S. Helicobacter pylori Vacuolating Cytotoxin, University of Pittsburgh Medical Center, Pittsburgh, Frankland,1 N. Klonis,1 J. Lippincott-Schwartz2; VacA, on Esophageal Cell Types. H. Isomoto,1 S. PA 1Biochemistry, La Trobe University, Bundoora, Kohno,1 K. Ohnita,1 J. Hisatsune,2 M. Nakayama,2 Australia, 2Cell Biology and Metabolism Branch, J. Moss,3 T. Hirayama2; 1Second Department of 1306 B450 Desmoplakin Signaling in NICHD, NIH, Bethesda, MD Vasculo and Angiogenesis. A. P. Miera, I. Internal Medicine, Nagasaki University, Nagasaki, 2 Gallicano; Cell Biology, Georgetown University, 1316 B461 The Parasite Giardia lamblia Japan, Tropical Medicine, Nagasaki University, 3 Washington, DC Uses an Osmotic Mechanism of Attachment. W. Nagasaki, Japan, NHLBI, National Institutes of R. Hansen, D. A. Fletcher; Biophysics, University of Health, Bethesda, MD 1307 B451 The RhoA Guanine Exchange California, Berkeley, Berkeley, CA Factor Syx Is Essential for Angiogenesis. M. 1325 B470 Disruption of the Parietal Cell Liu,1 R. Marx,2 K. Moodie,1 Q. Fu,1 S. Yan,3 Z. 1317 B462 Examining the Forces and Apical Membrane-Cytoskeleton Interaction by Zhuang,4 J. Baraban,2 A. Horowitz1; 1Medicine, Mechanism of Attachment by Giardia lamblia to Helicobacter pylori VacA Contributes to 1 2 1 Dartmouth Medical School, Lebanon, NH, Inert Substrates. T. J. Picou,1 R. G. McAllister,2 J. Hypochlorhydria. Z. Guo, X. Ding, X. Zhao, Y. 1 1 1 1 1 2Neuroscience, Johns Hopkins Medical School, B. Cohen,1 D. A. Elliott,3 J. S. Urbach,2 H. G. Liu, D. Wang, D. Liu, X. Yao ; Cell Biology, 2 Baltimore, MD, 3Pathology, Dartmouth Medical Elmendorf1; 1Biology, Georgetown University, Hefei National Laboratory, Hefei, China, Internal School, Lebanon, NH, 4Radiology, Dartmouth Washington, DC, 2Physics, Georgetown University, Medicine, Beijing University of Medicine, Beijing, Medical School, Lebanon, NH Washington, DC, 3Cell Biology, University of China Arizona College of Medicine, Tucson, AZ 1308 B452 In Vivo Roles of Endogenous 1326 B471 Shiga Toxin Toxicity and Ccd42 and Rac in Individual Neuronal Sub- 1318 B463 Identification of Microfilament Resistance in Tetrahymena. W. Lainhart, G. Compartments during Development. M. A. Associated Proteins in Giardia lamblia. H. Luo, Stolfa, T. M. Hennessey, G. Koudelka; Biological Hayden, D. Kamiyama, A. Chiba; Biology, H. G. Elmendorf; Biology, Georgetown University, Sciences, University at Buffalo, Amherst, NY University of Miami, Coral Gables, FL Washington, DC 1327 B472 Shiga Toxin 1 Induces 1309 B453 Activated Ras Alters Lens and 1319 B464 Filarial Prostaglandin Synthase: Apoptosis in the Human Myelogenous Corneal Differentiation. V. Govindarajan,1 Y. An Innovative Drug Target. A. Singh, M. Yadav, Leukemia Cell Line THP-1 through the ER Zhang,1 P. A. Overbeek,2 D. J. Burgess1; 1Surgery, R. Rai, S. Rathaur; Biochemistry, Banaras Hindu Stress Response. M. S. Lee, S. Y. Lee, R. P. Creighton University, Omaha, NE, 2Molecular & University, Varanasi, India Cherla, V. L. Tesh; Microbial and Molecular Cellular Biology, Baylor College of Medicine, Pathogenesis, Texas A&M University Health Houston, TX 1320 B465 In Vitro Immune Response of Science Center, College Station, TX Low Molecular Taenia solium Cyst Fluid 1310 B454 Rac Activation and Localization Antigens. A. Prasad,1 R. K. Gupta,2 S. Pradhan,3 1328 B473 Pseudomonas aeruginosa CFTR during Chondrocyte Maturation. B. Kerr, T. M. Tripathi,4 K. N. Prasad1; 1Microbiology, Sanjay Inhibitory Factor (Cif) Toxin Reduces MHC Otani, M. Iwamoto, M. Enomoto-Iwamoto; Gandhi Postgraduate Institute of Medical Sciences, Class I Presentation in Human Polarized Airway 1 2 Orthopaedic Research, Thomas Jefferson Lucknow, UP, India, 2Radiodiagnosis, Sanjay Epithelial Cells. J. Bomberger, N. Bangia, G. 3 3 1 1 University, Philadelphia, PA Gandhi Postgraduate Institute of Medical Sciences, O'Toole, W. Green, B. Stanton ; Physiology, Lucknow, UP, India, 3Neurology, Sanjay Gandhi Dartmouth Medical School, Hanover, NH, 2 1311 B455 FAK Is Required for Axonal Postgraduate Institute of Medical Sciences, Immunology, Roswell Park Cancer Institute, 1 3 Sorting by Schwann Cells. M. P. C. Grove, N. H. Lucknow, UP, India, 4Anesthesia, Sanjay Gandhi Buffalo, NY, Microbiology and Immunology, 2 2 2 Komiyama, K. Navin, S. G. Grant, D. L. Postgraduate Institute of Medical Sciences, Dartmouth Medical School, Hanover, NH 1 1 1 Sherman, P. J. Brophy ; Centre for Neuroscience Lucknow, UP, India Research, Edinburgh University, Edinburgh, United 1329 B474 The Pseudomonas aeruginosa Kingdom, 2Wellcome Trust, Sanger Institute, 1321 B466 Analysis of DC (doublecortin- Pigment Pyocyanin Inhibits the Dual Oxidase- Hinxton, United Kingdom like) Domain Containing Protein in Toxoplasma mediated Antimicrobial Defense System in gondii. E. Nagayasu, J. M. Murray; Cell and Human Airways. B. Rada, K. Lekstrom, T. Leto; 1312 B456 MMP-2 functions as a Negative Developmental Biology, University of Pennsylvania LHD, NIH, NIAID, Rockville, MD Regulator of Chondrogenic Cell Condensation School of Medicine, Philadelphia, PA via Downregulation of the FAK-integrin ␤1. E. 1330 B475 WITHDRAWN Jin,1 Y. Choi,1 O. Bang,2 S. Kang1; 1Biological 1322 B467 Interaction of Leishmania 1331 B476 Altered Maturation of Chlamydia Sciences, Kyungpook National University, Daegu, chagasi with Peritoneal Mouse Macrophages. D. Compartments in Infected Macrophages. E. W. Republic of Korea, 2Department of Medical P. Vieira,1 F. P. Dutra,1 M. T. Gomes,1 M. A. C. Y. Eng, M. Binker, R. E. Harrison; Department of Research, Korea Institute of Oriental Medicine, Silva-Neto,2 A. H. Lopes1; 1Instituto de Biological Sciences, University of Toronto at Daejeon, Republic of Korea Microbiologia, Universidade Federal do Rio de Scarborough, Scarborough, ON, Canada Janeiro, Rio de Janeiro, R.J., Brazil, 2Instituto de 1313 B457 Scaffolding Proteins Are Bioquimica Medica, Universidade Federal do Rio 1332 B477 Dissecting the Response of Necessary for Muscle Cell Differentiation. J. J. de Janeiro, Rio de Janeiro, R.J., Brazil Macrophages to Mycobacterial Infection. M. Paylor, J. C. Camaren, K. Ewald, K. Cox, S. A. K. Khounlotham,1 R. Smith,2 J. D. Cirillo1; 1Microbial Byrd; Biology, Fort Lewis College, Durango, CO 1323 B468 A Method to Obtain and Molecular Pathogenesis, Texas A&M University Trypanosomatid-free Phytophagous Insect System Health Science Center, College Station, Oncopeltus fasciatus (Milkweed Bug). F. A. TX, 2Veterinary Pathobiology, College of Veterinary Parasitology Dias,1 T. L. Alves e Silva,1 M. F. Cardoso de Medicine, Texas Veterinary Medical Center, College Almeida,1 L. T. Zimmermann,1 E. M. Saraiva,1 M. Station, TX 1314 B459 Effects of Different Attias,2 T. C. Souto-Padron,1 A. H. Lopes1; Erythopoietic and Immune Responses on the 1Instituto de Microbiologia, Universidade Federal do 1333 B478 Sex Differences in the Impact of Outcome of Human Malaria: Insight from Rio de Janeiro, Rio de Janeiro, Brazil, 2Instituto de Ozone on Macrophage Function of Wild Type 1 Numerical Studies. P. G. McQueen, F. E. Biofisica, Universidade Federal do Rio de Janeiro, and SP-A(-/-) Mice after Klebsiella pneumoniae 2 1 McKenzie ; MSCL/DCB/CIT, National Institutes of Rio de Janeiro, Brazil Infection. A. N. Mikerov, X. Guo, J. Floros; Cellular 2 Health, Bethesda, MD, JEFIC, National Institutes and Molecular Physiology, Penn State University of Health, Bethesda, MD College of Medicine, Hershey, PA

118 The American Society for Cell Biology 47th Annual Meeting MONDAY December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org Poster Session 2 B479–B505

1334 B479 4-1BB Activation in Early Phase 1342 B487 Mapping Latent Lesions in 1352 B497 Transcriptional Repression of of Listeria monocytogens Infection Eliminates Lobster Shell Disease. J. G. Kunkel; Biology, hTERT Using Artificial Transcription Factors. J. Infected Bacteria. T. Nguyen,1 B. Sung,1 S. Park,1 University of Massachusetts–Amherst, Amherst, Sohn, J. Yoon, J. Namkung, B. Yeh; Department of B. Kim1,2; 1Biological Sciences, University of Ulsan, MA Biochemistry, Wonju College of Medicine, Yonsei Ulsan, Republic of Korea, 2Immunomodulation University, Wonju, Republic of Korea Research Center, Ulsan, Republic of Korea 1343 B488 Modification of the RAS1-cAMP- Protein Kinase A Pathway in Candida albicans 1353 B498 SUZ12-mediated Two 1335 B480 Clathrin Is Required for by Farnesol and Dodecanol. A. Piispanen, A. Methylation Paths in the Silencing Regulation Extracellular Enteropathogenic E. coli Actin- Davis-Hanna, D. Hogan; Microbiology, Dartmouth of Human CEBPD Gene. C. Ko1,2; 1National mediated Pedestal Formation. J. A. Guttman,1 E. Medical School, Hanover, NH Cheng Kung University, Tainan, Taiwan, 2Basic Veiga,2 A. E. Lin,1 P. Cossart,2 B. B. Finlay1; Medical Sciences, Tainan, Taiwan 1Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada, 2Unité des Cancer II 1354 B499 Tylophorine Elevates the interactions Bactéries-Cellules, Institut Pasteur, Amounts of c-Jun Protein in Carcinoma Cells. Paris, France 1344 B489 Role of Grape Polyphenols in S. Lee, C. Wu, C. Yang; Division of Biotechnology Metastatic Breast Cancer. L. Castillo-Pichardo,1 and Pharmaceutical Research, National Health 1336 B481 Stimulation of Lung Innate A. De La Mota-Peynado,2 L. Rivera,2 L. A. Research Institutes, Taipei, Taiwan Immunity Protects against a Broad Range of Cubano,2 S. Dharmawardhane3; 1Biochemistry, 1 1 1355 B500 Role of CK2 in Apoptotic Infectious Microbes. B. L. Scott, C. Clement, J. University of Puerto Rico–Medical Sciences 2 1 1 1 Activity of Resveratrol (RSV) and Peterson, M. Tuvim, B. F. Dickey ; Pulmonary Campus, San Juan, PR, 2Anatomy and Cell Epigallocatechin-3-gallate (EGCG). G. Wang, K. Medicine, M.D. Anderson Cancer Center, Houston, Biology, Universidad Central del Caribe, San Juan, 2 A. Ahmad, N. Harris, K. Ahmed; Research Service/ TX, UT Medical Branch, Galveston, Galveston, TX PR, 3Cell Biology, Universidad Central del Caribe Laboratory of Medical Pathology, V.A. Medical and University of Puerto Rico–Medical Sciences 1337 B482 Staphylococcal Adhesion and Center/University of Minnesota, Minneapolis, MN Campus, San Juan, PR Subsequent Changes in Fibroblasts. K. Seki,1 H. 2 1 1 1 1356 B501 Cancer Stem Cell Being Utilized Sasaki, H. Shinji, Y. Mizunoe ; Bacteriology, The 1345 B490 Lipotropes (Methyl Nutrients) in Cell-based Assay Screening in the Jikei University School of Medicine, Tokyo, Japan, Enhance Human Breast Cancer Cell Death. K. 2 Development of Novel Anti-Cancer Drug Institute of DNA Medicine, The Jikei University Cho, C. S. Park; Animal and Range Sciences, Candidates for Organ Specific Tumor Therapy. School of Medicine, Tokyo, Japan North Dakota State University, Fargo, ND J. Sharma, F. M. Byhower, C. R. Sharma, H. Eran, 1338 B483 The Activation of the Sentinel 1346 B491 Anticancer Properties of Some M. R. Sharma, L. J. Byhower, S. K. Sharma, K. Receptor PGRP-LC in Response to Gram- Medicinal Plants. S. Sundaram; Centre of Okbaok; Molecular Biology, Celprogen, San Pedro, negative Bacterial Infection in Drosophila. A. H. Biotechnology, University of Allahabad, Allahabad, CA Tang,1 R. L. Schmidt,2 F. M. Rinaldo,3 S. E. India Hesse,3 S. Cheng,3 Z. Ortiz,3 T. R. Trejo,3 A. Page- 1357 B502 The Geodiamolide H, Derived McCaw,4 J. L. Platt5; 1Departments of Surgery, and 1347 B492 Modulation of Angiogenesis by from Brazilian Sponge Geodia corticostylifera, Biochemistry Molecular Biology, Mayo Clinic Beer Polyphenols. R. Negrão, I. Azevedo, R. Regulates Actin Cytoskeleton, Migration, and College of Medicine, Rochester, MN, 2Department Soares; Department of Biochemistry, Faculty of Invasion of Breast Cancer Cells Cultured in 1 of Biochemistry Molecular Biology, Mayo Clinic Medicine, University of Porto (U38/FCT), Porto, Three-Dimensional Environment. V. M. Freitas, 2 1 1 College of Medicine, Rochester, MN, 3Department Portugal M. Rangel, L. F. Bisson, R. G. Jaeger, G. M. 1 1 of Surgery, Mayo Clinic College of Medicine, Machado-Santelli ; Department of Cellular and Rochester, MN, 4Department of Biology and Center 1348 B493 Investigations of Anti-Cancer Developmental Biology, University of Sao Paulo, 2 for Biotechnology and Interdisciplinary Studies, Compounds from White Tea, Green Tea, and Sao Paulo, Brazil, Department of Essiac Extracts. J. Powell,1 C. Lyons,1 T. Gary,2 Immunopathology, Butantan Institute, Sao Paulo, Rensselaer Polytechnic Institute, Troy, NY, 1 1 1 5 Y. Myles, E. Myles ; Biological Sciences, Brazil Departments of Surgery, Immunology, and 2 Pediatrics, Mayo Clinic College of Medicine, Tennessee State University, Nashville, TN, Center of Excellence and Information System and 1358 B503 Investigation of Anti-CD22-MCC- Rochester, MN Engineering, Tennessee State University, Nashville, DM1 and -MC-MMAF Conjugates Using 1339 B484 Abelson Tyrosine Kinase TN Biochemical and Cell-based Assays. P. P. F. 1 2 3 1 Regulates CrkII Adaptor Protein during Chan, C. C. Lee, C. Nelson, J. Akutagawa, D. 1349 B494 In Vitro Anticancer Activity of 4 3 2 1 Salmonella typhimurium Entry into Host Cells. Xie, J. M. Elliott, C. Bechtel, W. T. Wong, R. 1 3 2 4 5 K. Ly, J. Casanova; Cell Biology, University of Nigerian Ethnomedicinal Plants. S. Adamson, Vandlen, F. Jacobson, S. Prabhu, A. Ebens, J. O. Fadey,2 C. Okoro,2 E. Myles1; 1Biological 1 1 Virginia, Charlottesville, VA P. Stephan ; Assay Automation Technology, Sciences, Tennessee State University, Nashville, Genentech, Inc., South San Francisco, CA, 2Early 1340 B485 Mechanisms of Neutrophil TN, 2Chemistry, Tennessee State University, Stage Analytical, Genentech, Inc., South San Exocytosis: Differential Regulation by the Nashville, TN Francisco, CA, 3Protein Isolation, Genentech, Inc., Signaling Molecules IRAK-4 and TRIF. A. A. South San Francisco, CA, 4Early Development 1350 B495 Tumor-specific Cytotoxicity of Brzezinska, J. L. Johnson, D. D. Munafo, B. A. PKPD, Genentech, Inc., South San Francisco, CA, Polyphenolic Compounds Isolated from Ellis, S. D. Catz; Molecular and Experimental 5Translational Oncology, Genentech, Inc., South Vaccinium macrocarpon. E. Correiro,1 A. Liberty,2 Medicine, The Scripps Research Institute, La Jolla, San Francisco, CA C. Neto,2 P. Hart3; 1Medical Laboratory Science, CA University of Massachusetts–Dartmouth, N. 1359 B504 Upregulation of Cyclin G2 1341 B486 In Vitro Binding Analysis of Dartmouth, MA, 2Chemistry and Biochemistry, Expression in B Cell Lymphoma and Breast MHC Class II-Superantigen-TCR V␤. K. University of Massachusetts–Dartmouth, N. Cancer Cell Lines by Cancer Therapeutics. A. Imanishi,1 W. Nunomura,2 K. Omoe,3 H. Kato,1 M. Dartmouth, MA, 3Biology, University of Arachchige Don,1 C. Cowan,1 J. Duven,1 X. Le,2 R. Araake,1 Z. Li,1 Y. Abe,3 H. Ono,3 O. Igarashi,4 D. Massachusetts–Dartmouth, N. Dartmouth, MA C. Bast,2 M. C. Horne1; 1Pharmacology, University Hu,5 A. Nakane,5 Y. Takakuwa,2 H. Kiyono,4 K. of Iowa, Iowa Ciity, IA, 2M.D. Anderson Cancer 1351 B496 Novel Targeting Mechanism of Shinagawa,3 T. Uchiyama1; 1Microbiology & Center, University of Texas, Houston, TX Human DNA Topoisomerase II by Mitoxantrone- Immunology, Tokyo Womens Medical University, Amino Acid Conjugates. C. Lee,1 J. Fan,1 H. Tokyo, Japan, 2Biochemistry, Tokyo Womens 1360 B505 Effective Treatments of 1 W. Chen,2 H. Chen,2 L. Hsin,2 T. Li1; Medical University, Tokyo, Japan, 3Veterinary Chen, Established Renca Tumors by Administration of 1Department and Graduate Institute of Medicine, Iwate University, Iwate, Japan, 4Mucosal 5-fluorouracil and Anti-4-1BB Monoclonal 1 1,2 1,2 1 Immunology, Institute of Medical Science, Microbiology, College of Medicine, National Taiwan Antibody. S. Park, S. Ju, B. Kim, B. Sung ; 2School of Pharmacy, 1 University of Tokyo, Tokyo, Japan, 5Bacteriology, University, Taipei, Taiwan, Biological Sciences, University of Ulsan, Ulsan, 2 Hirosaki University, Hirosaki, Japan College of Medicine, National Taiwan University, Republic of Korea, Immunomodulation Research Taipei, Taiwan Center, Ulsan, Republic of Korea

119 MONDAY The American Society for Cell Biology 47th Annual Meeting Poster Session 2 B506–B532 December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org

1361 B506 The Effects of Two Novel Drugs, 1370 B515 Autophagy Protein Antibodies 1379 B524 Investigation of the Mechanism "DJ Compounds" on COX-2 Gene Expression in as Pathology Markers. J. Mountzouris,1 J. Liu,1 J. of Severe Familial Amyloidotic Polyneurophaty. Normal and Transformed Human Prostate Cell Zou,1 Y. He,1 K. Gramatikoff2; 1Abgent, San Diego, M. Miyata,1 T. Sato,1 S. Susuki,1 T. Nakamura,2 S. Lines. D. Thompson; University of Massachusetts, CA, 2The Burnham Institute for Medical Research, Ikemizu,2 M. A. Suico,1 T. Shuto,1 M. Mizuguchi,3 Nashua, NH San Diego, CA Y. Ando,4 Y. Yamagata,2 H. Kai1; 1Molecular Medicine, Graduate School of Pharmaceutical 1362 B507 The Histone Deacetylase 1371 B516 The Varying Effects of Science, Kumamoto University, Kumamoto, Japan, Inhibitor CHAP31 Has Antitumor Activity Intermediate Filament Aggregates upon Cell 2Structual Biology, Graduate School of against Esophageal Cancer Cells Mediated by Viability. R. A. Quinlan, M. Perng, S. Wen; School Pharmaceutical Sciences, Kumamoto University, 1 the Intrinsic Pathway. K. Murakami, H. of Biological and Biomedical Sciences, Durham Kumamoto, Japan, 3Structual Biology, Faculty of 1 1 1 Matsubara, Y. Akutsu, Y. Miyazawa, K. University, Durham, United Kingdom Pharmaceutical Sciences, Toyama University, 1 1 1 1 Matsushita, H. Sakata, T. Nishimori, A. Usui, M. Toyama, Japan, 4Laboratory Medicine, Graduate 1 2 1 1372 B517 Effect of FMR1 CGG Repeat Kano, M. Yoshida ; Department of Frontier School of Medical Sciences, Kumamoto University, Size on Fragile X Mental Retardation Protein Surgery, Graduate School of Medicine, Chiba Kumamoto, Japan University, Chiba, Japan, 2RIKEN, Tsukuba, Japan (FMRP) Levels Among Normal and Premutation Carriers. E. Peprah, E. Allen, W. He, J. Hunter, S. 1380 B525 Functional Characterisation of 1363 B508 Identification and Sherman; Human Genetics, Emory University, the Protein Encoded by the Dyslexia-associated Characterization of Potential Shwachman- Atlanta, GA Gene KIAA0319. A. Velayos-Baeza,1 C. Toma,2 S. 1 Diamond Syndrome Therapeutics. C. Knight, C. Paracchini,1 K. Kobayashi,3 A. P. Monaco1; 1 1 2 1373 B518 Loss of Usp14 Results in Gruber, J. Blackwell, A. Garrido-Lecca, A. 1Wellcome Trust Centre for Human Genetics, 3 3 1 Motorneuron Dysfunction. P. Chen, S. M. Wilson; Papusha, C. Kosinetz, P. de Figueiredo, J. N. University of Oxford, Oxford, United Kingdom, 4 1 Neurobiology, University of Alabama at Huang ; Texas A&M University, College Station, 2Department of Biology, University of Bologna, 2 Birmingham, Birmingham, AL TX, University of Colorado Health Sciences Bologna, Italy, 3Department of Medical Genetics, Center, Denver, CO, 3Baylor College of Medicine, 1374 B519 Serine-palmitoyltransferase Osaka University Graduate School of Medicine, Houston, TX, 4Pediatrics, University of California, Subunit SPTLC2 Is Required for the Osaka, Japan San Francisco School of Medicine, San Francisco, Recruitment of SPTLC1 to the Endoplasmic CA 1381 B526 The Role of LRRK2 in EGFr Reticulum. P. K. Moitra,1 T. M. Dunn,2 J. M. Signaling Pathway in Patient Lymphoblasts. R. Harmon,1 G. Ihrke1; 1Department of Pharmacology, 1364 B509 Opioids and the Migration, Ahmad, E. Greggio, M. Cookson; NIH/NIA, Chemotaxis, Invasion, and Adhesion of Human Uniformed Services University School of Medicine, 2 Bethesda, MD Cancer Cells. K. A. Rahn, P. J. McLaughlin, I. S. Bethesda, MD, Department of Biochemistry and Zagon; Neural and Behavioral Sciences, Penn Molecular Biology, Uniformed Services University 1382 B527 Up-Regulation of Neuronal State University, Hershey, PA School of Medicine, Bethesda, MD Pentraxin-1 during the Onset and Progression 1375 B520 HIPK4: A Novel Striatum- of Neurodegeneration in Sandhoff Disease 1365 B510 The OGF-OGFr Axis Is a Mouse Model. S. Salman,1 B. Trigatti,2 C. Nurse,1 Determinant in the Progression of Ovarian enriched Protein Kinase That Regulates Cell 1 1 1 2 2 2 S. Igdoura ; Biology, McMaster University, Cancer. R. N. Donahue, I. S. Zagon, P. J. Death. F. Lo, W. Liu, L. Wu, S. Haney, B. 2 3 1 Hamilton, ON, Canada, Biochemistry and McLaughlin; Neural and Behavioral Science, Penn Ozenberger ; Wyeth Neuroscience, Princeton, NJ, 2 Biomedical Sciences, McMaster University, State College of Medicine, Hershey, PA Wyeth Discovery Genomics, Cambridge, MA, 3National Research Institute, Hamilton, ON, Canada 1366 B511 Truncation of Annexin A1 Is a National Institutes of Health, Bethesda, MD 1383 B528 Rabs and Rafts in Alzheimer´s Regulatory Lever for Linking EGF Signaling 1 1 2 1376 B521 TorsinA Participates in Linking Disease. L. Rajendran, M. Honsho, K. Geiger, with Cytosolic Phospholipase A2 in Normal and K. Simons1; 1Max Planck Institute of Molecular Cell Malignant Squamous Epithelial Cells. H. Murata, the Nuclear Envelope to Intermediate Filaments. 1 1 1 1 Biology and Genetics, Dresden, Germany, M. Sakaguchi, H. Sonegawa, Y. Sakaguchi, J. F. C. Nery, J. Zeng, B. P. Niland, J. Hewett, Y. 2 2 3 4 1 Pathology, Uni Klinikum, Technical University of Futami, M. Kitazoe, H. Yamada, N. Huh; Okayama Li, G. Wiche, A. Sonnenberg, X. O. Breakefield ; 1 Dresden, Dresden, Germany University, Okayama, Japan Neurology/Radiology, Massachusetts General 2 Hospital, Boston, MA, Neurology, University of 1384 B529 Novel Signaling Pathways 3 Alabama, Birmingham, AL, Molecular Cell Biology, Regulated by Prostanoid Receptors in Human 4 Neuronal Diseases I University of Vienna, Vienna, Austria, Cell Biology, Ciliary Smooth Muscle Cells. A. J. Hutchinson,1 Netherlands Cancer Institute, Amsterdam, The S. C. Coons,2 W. D. Stamer,2 J. W. Regan3; 1367 B512 ERK Phosphorylates and Netherlands 1Program in Neuroscience, University of Arizona, Regulates Disrupted-in-Schizophrenia 1 2 1377 B522 Par-4 Exacerbates Cortical Tucson, AZ, Department of Ophthalmology and (DISC1). S. Taya, J. Uraguchi-Asaki, K. Kuroda, K. Neuronal Death in Models of Traumatic Brain Vision Science, University of Arizona, Tucson, AZ, Kaibuchi; Department of Cell Pharmacology, 3Department of Pharmacology and Toxicology, Injury In Vitro and In Vivo. D. J. Payette, J. Xie, Nagoya University Graduate School of Medicine, University of Arizona, Tucson, AZ N. Shirwany, Q. Guo; Department of Physiology, Nagoya, Japan The University of Oklahoma Health Sciences 1385 B530 Different Neurological Stresses 1368 B513 Studies on Biological Effects of Center, Oklahoma City, OK Induce Cofilin-Actin Rod Formation in Different Sodium Dichloroacetate Using Mitochondrial Subregions of Hippocampal Organotypic Slices. 1378 B523 Increased Vulnerability of Disease Models. E. Ogasawara,1 N. Kazuto,1,2 H. R. C. Davis; Biochemistry and Molecular Biology, Hippocampal Neurons to Apoptosis and Jun-Ichi1; 1Graduate School of Life and Colorado State University, Fort Collins, CO Oxidative Injury Induced by Amyloid Beta Environmantal Sciences, Univ. of Tsukuba, Peptides in Par-4 Transgenic Mice. J. Xie, Q. Tsukubashi, Japan, 2Center for Tsukuba Advanced 1386 B531 Intracellular Transport, Amyloid Guo; Department of Physiology, The University of Research Alliance, University of Tsukuba, Precursor Protein, and Herpesvirus: Cell Oklahoma Health Sciences Center, Oklahoma City, Tsukubashi, Japan Biological Evidence for Disease Mechanisms. OK D. Nobrega,1 S. Cheng,2 A. Chirila,2 K. Sylvester,2 1369 B514 Defective Retrotranslocation E. L. Bearer2; 1Marine Biological Laboratory, Brown Causes Loss of Anti-Bax Function in Human University Medical School, Woods Hole, MA, Familial Prion Protein Mutants. J. Jodoin,1,2 S. 2Pathology and Laboratory Medicine, Brown Laroche-Pierre,1,2 C. G. Goodyer,3 A. C. University Medical School, Providence, RI LeBlanc1,2; 1Neurology and Neurosurgery, McGill University, Montreal, PQ, Canada, 2Bloomfield 1387 B532 The Amyloid-␤ Precursor Center for Research in Aging, Lady Davis Institute Protein Is Phosphorylated via at Least Six for Medical Research, Sir Mortimer B. Davis Jewish Distinct Pathways during Differentiation, General Hospital, Montreal, PQ, Canada, Mitosis, Stress, and Degeneration. Z. Muresan, 3Pediatrics, McGill University, Montreal, PQ, V. Muresan; Pharmacology and Physiology, Canada UMDNJ–New Jersey Medical School, Newark, NJ

120 The American Society for Cell Biology 47th Annual Meeting MONDAY December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org Poster Session 2 B533–B559

Other Diseases II 1396 B541 Changes in Fungal Protein 1405 B550 Membrane Fluidity and Lipid Populations during the Temperature-induced Composition in Clinical Isolates of Candida Dimorphic Switch in Penicillium marneffei. J. M. albicans Isolated from AIDS/HIV Patients. D. K. 1388 B533 A Novel Model for Chandler,1 E. R. Treece,2 J. L. Frommelt,3 H. R. Gupta; Biochemistry & Bioinformatics, University of Understanding Mechanisms of Collective Trenary,4 T. D. Kim,2 C. R. Cooper,1 G. R. Walker1; Allahabad, Allahabad, India Migration and EMT. J. L. Walker, L. Zhang, I. M. 1Biological Sciences, Youngstown State University, Wolff, A. S. Menko; Thomas Jefferson University, Youngstown, OH, 2Chemistry, Rochester Institute of 1406 B551 Impact of Bone Marrow-derived Philadelphia, PA Technology, Rochchester, NY, 3Biological Sciences, Mesenchymal Stem Cells on Lung Edema, 4 Injury, and Repair in an Animal Model Exposed 1389 B534 Paxillin Is a Dynamic Mechano- Miami University, Oxford, OH, Chemistry, to Bleomycin. A. Jang, Y. Kim, S. Lee, C. Park; activator in Myocytes That Is Up-Regulated in University of Cincinnati, Cincinnati, OH Allergy and Respiratory Diseases, Soonchunhyang Muscular Dystrophies and Signals for 1397 B542 Effect of Astragallus University Hospital, Bucheon, Republic of Korea Contractility and Differentiation. M. Tewari,1 S. membranaceus against Inflammation and Sen,1 A. Engler,1 M. Zad,2 P. Acousta,2 E. Barton,3 Obesity in Murine Cell Lines. S. Jung, H. Kim, D. H. L. Sweeney,2 D. E. Discher1; 1SEAS, University Lee; Life Sciences, University of Seoul, Seoul, Cell Motility - Techniques of Pennsylvania, Philadelphia, PA, 2PMI, University Republic of Korea 3Dental School, of Pennsylvania, Philadelphia, PA, 1407 B552 In Search of ECM: Live-Cell University of Pennsylvania, Philadelphia, PA 1398 B543 Overexpression of Kidins220/ Imaging of Micro-patterned Substrata. A. D. ARMS Protein in Polycystic Kidney Disease and 1 2 1 1 1390 B535 Up-Regulation of Doyle, F. W. Wang, K. M. Yamada ; Laboratory Intrahepatic Biliary Tree Disease. H. Huang, M. Hemoxygenase-1 Provides a Novel Therapeutic of Cell and Developmental Biology, NIDCR/NIH, Tsai, S. Hsu, P. Huang; Department of Pathology, 2 Approach in Acute Experimental Pancreatitis. A. Bethesda, MD, Material Science and Engineering National Taiwan University Hospital, Taipei, Taiwan Habtezion,1 R. Kwan,1 H. Zheng,1 S. Collins,2 E. Laboratory, NIST, Gaithersburg, MD 3 1 1 Butcher, M. Omary ; Medicine, VA Palo Alto 1399 B544 Evaluation of Pulmonary 1408 B553 Developing an Activation Health Care System and Stanford University Damage by Ambient Air Pollutant. Y. Kim,1 D. 2 Biosensor for Endogenous PAK1 by Digestive Disease Center, Palo Alto, CA, Ovation Roh,1 T. Jo,1 H. Kim,1 J. Byun,1 J. Lee,1 S. Do,2 S. Computationally Evolving the PAK1 Pharmaceuticals, Deerfield, IL, 3Pathology, VA Palo 3 1 1 1 Jung, Y. Hwang, D. Kim ; Division of Biological Autoinhibitory Domain. Y. I. Wu,1 R. Jha,2 D. Alto Health Care System and Stanford University Science, Gachon University of Medicine and Gremyachinskiy,1 L. V. Parise,2 B. Kuhlman,2 K. M. Digestive Disease Center, Palo Alto, CA Science, Incheon, Republic of Korea, 2Clinical Hahn1; 1Department of Pharmacology, University of Pathology, College of Veterinary Medicine, Konkuk 2 1391 B536 Characterization and Expression North Carolina, Chapel Hill, NC, Department of University, Seoul, Republic of Korea, 3Clinical of Cytoplasmic (␤ & ␥) in LLC-PK1-CL4 Biochemistry and Biophysics, University of North Medicine, Graduate School of Medicine, Gachon Cells to Elucidate the Role of ␥-actin Mutations Carolina, Chapel Hill, NC University of Medicine and Science, Incheon, Causing Non-syndromic Hearing Loss. S. Republic of Korea 1409 B554 Use of a Fluorescent Biosensor Korrapati, M. Zhu, K. Friderici; Michigan State to Visualize Cellular Polarity in Live Migrating University, East Lansing, MI 1400 B545 Effects of Asian Sand Dust Cells. A. C. Uetrecht, J. E. Bear; Lineberger Stress to Mitochondrial Heat Shock Protein- 1392 B537 Proteomic Identification of Comprehensive Cancer Center and Department of 60kD (HSP60) in Human Cell Line and Mice Cellular Proteins with Potential Roles in Nuclear Cell and Developmental Biology, University of Tissue. M. Kim, S. Kim, H. Lee, D. Kim, Y. Hwang; Export and Metabolism of HIV mRNAs. G. North Carolina at Chapel Hill, Chapel Hill, NC Division of Biological Science, Gachon University of Ambrus-Aikelin, J. Johnson, J. R. Yates, L. Gerace; Medicine & Science, Incheon, Republic of Korea 1410 B555 Biosensors of GDI-GTPase Cell Biology, The Scripps Research Institute, La Interaction: A Generally Applicable FRET Jolla, CA 1401 B546 Ectopic Calcification in mdx ‘Binding Antenna’ Applied to Study GDI-RhoA, Mouse Skeletal Muscle IV. N. Kikkawa, M. 1393 B538 Abnormalities in Expression and Rac1 and Cdc42 Interactions. Simultaneous Shiozuka, R. Matsuda; The Graduate School of Topographic Localization of Solute and Water Imaging Reveals Coordination of Cdc42 Arts and Sciences, The University of Tokyo, Tokyo, Transporters in Cholangiocytes of the PCK Rat, Nucleotide State and Cdc42-GDI Interaction In Japan an Animal Model of Autosomal Recessive Vivo. L. Hodgson, K. Hahn; Pharmacology, University of North Carolina at Chapel Hill, Chapel Polycystic Kidney Disease (ARPKD), Are 1402 B547 Identification of Conserved Hill, NC Associated with Hepatic Cystogenesis. J. M. Water Sites in Bacterial Alanine Racemase for 1,2 T. V. Masyuk,1 P. S. Tietz,1 S. Lee,1 B. 1 1 Banales, Drug Design. H. Huang, D. Jupiter, J. M. 1411 B556 Genetically Encoded Biosensors Q. Huang,1 A. J. Stroope,1 S. A. Gradilone,1 A. I. 2 1 1 Briggs, V. VanBuren ; Department of Systems for Endogenous Src Activation Based on High Masyuk,1 J. F. Medina,2 N. F. LaRusso1; 1Center Biology and Translational Medicine, College of Throughput Screening of Engineered Biosensor for Basic Research in Digestive Disease, Division Medicine, Texas A&M Health Science Center, Scaffolds. E. A. Vitriol,1,2 L. Hodgson,2 A. of Gastroenterology and Hepatology, Mayo Clinic Temple, TX, 2Department of Biology and Gulyani,2 P. Pal,2 B. K. Kay,3 K. M. Hahn2; 1Cell 2Laboratory of College of Medicine, Rochester, MN, Biochemistry, University of Houston, Houston, TX and Developmental Biology, University of North Molecular Genetics, Division of Gene Therapy and Carolina at Chapel Hill, Chapel Hill, NC, 1403 B548 Bovine Lactoferrin and Hepatology, University of Navarra School of 2Pharmacology, University of North Carolina at Lactoferricin Interfere with Intracellular Medicine, Clínica Universitaria and CIMA, Chapel Hill, Chapel Hill, NC, 3Biological Sciences, Trafficking of Herpes Simplex-1. A. K. Marr,1 H. Pamplona, Spain University of Illinois at Chicago, Chicago, IL Jenssen,2 N. Pante1; 1Department of Zoology, 1394 B539 Liver Disease and Its Relation to University of British Columbia, Vancouver, BC, 1 1412 B557 Photoactivatible Thresholding: the Lipid Mediators S1P and LPA. L. Johnson, Canada, 2Department of Microbiology and Seeing More by Seeing Less. C. Galbraith,1 J. J. Thompson,1 F. Chan,1 M. Liew2; 1Echelon Immunology, University of British Columbia, Galbraith2; 1NIDCR, NIH, Bethesda, MD, 2NINDS, Biosciences Inc., Salt Lake City, UT, 2ARUP Vancouver, BC, Canada NIH, Bethesda, MD Laboratories, Salt Lake City, UT 1404 B549 The Effects of O-GlcNAc 1413 B558 Synthetic Activation of Native 1395 B540 Evaluation of the Effectiveness 1 Modification in Cataractogenesis. K. Wang, S. PI3K and Rac Identifies an AND-gate Module for of a Mast Cell Degranulation Inhibitor in Ho,2 W. Mao,3 F. Zhang,4 P. Huang,5 J. E. 1,2 Neutrophil Polarization. T. Inoue, T. Meyer; Dystrophic mdx Mice. D. D. Araujo, F. S. M. Kudlow,4,1,5 A. J. Paterson4,1; 1Physiology and 2 2 2 Chemical & Systems Biology, Stanford University, Pires, T. T. Fuzisaki, J. C. S. Bizario, M. R. Biophysics, University of Alabama at Birmingham, 1,2 1 Stanford, CA Costa ; Cellular Molecular Biology, University of Birmingham, AL, 2Cell Biology, University of 2 São Paulo, Ribeirão Preto, Brazil, Medicine Alabama at Birmingham, Birmingham, AL, 3Vision 1413A B559 A Novel High Throughput- School, University of Ribeirão Preto, Ribeirão Science, University of Alabama at Birmingham, compatible Cell Migration Screening Assay. S. Preto, Brazil Birmingham, AL, 4Medicine, University of Alabama Soltaninassab, J. Sotos, M. Bonds, L. Williams, J. at Birmingham, Birmingham, AL, 5Pharmacology Williams, N. Abbott, C. J. Murphy; Platypus and Toxicology, University of Alabama at Technologies, LLC, Madison, WI Birmingham, Birmingham, AL

121 MONDAY The American Society for Cell Biology 47th Annual Meeting Poster Session 2 B560–B589 December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org

Cell Motility - Structural Basis 1423 B569 Right Time, Right Place and 1433 B579 SZY-5, a Novel Regulator of Only Once: The Control of Centrosome Number. Centriole Duplication in C. elegans. N. B. A. Ferreira,1,2 W. Zhang,3 K. S. Lilley,4 E. D. Laue,3 Miliaras, K. F. O'Connell; Laboratory of 1414 B560 Palladin Expression in D. M. Glover,2 M. Bettencourt-Dias1; 1Instituto Biochemistry and Genetics, National Institute of Metastatic Breast Cancer Cells: A Role in Gulbenkian de Ciencia, Oeiras, Portugal, Diabetes Digestive and Kidney Diseases, Invasive Motility. S. M. Goicoechea,1 X. Wang,1 2Department of Genetics, University of Cambridge, Bethesda, MD A. Aghajanian,2 H. Prentice-Dunn,1 C. A. Otey1; Cambridge, United Kingdom, 3Department of 1Cell and Molec. Physiology, University of North ␥ Biochemistry, University of Cambridge, Cambridge, 1434 B580 Functional Analyses of - Carolina–Chapel Hill, Chapel Hill, NC, 2Cell and United Kingdom, 4Cambridge Center for Tubulin Complex Proteins of Aspergillus Developmental Biology, University of North Proteomics, University of Cambridge, Cambridge, nidulans. Y. Xiong, B. R. Oakley; Molecular Carolina–Chapel Hill, Chapel Hill, NC United Kingdom Genetics, The Ohio State University, Columbus, OH 1415 B561 Myosin II Drives Glioma 1424 B570 Regulation of Centrosome Invasion through a Specific Mechanism. S. S. Duplication by an Unlicensing Mechanism. G. 1435 B581 The Role of NEDD1 Rosenfeld,1 P. Canoll,2 C. Beadle,1 R. Vallee,2 P. C. Rogers, N. M. Rusan, M. Peifer, S. L. Rogers; Phosphorylation in gamma-Tubulin Recruitment Monzo2; 1Neurology, Columbia University, New 1 Biology, University of North Carolina, Chapel Hill, to the Mitotic Centrosome. L. Haren, A. Di York, NY, 2Pathology, Columbia University, New 1 1 1 2 NC Paolo, L. Mazzolini, M. Remy, A. Renner, Y. York, NY Menon,2 L. Creancier,2 C. Bailly,2 A. Merdes1; 1425 B571 From Stem Cell to Embryo: 1UMR2587, ISTMT, CNRS-Pierre Fabre, Toulouse, 1416 B562 The Performance of Molecular Oogenesis without Centrioles. N. R. Stevens, A. France, 2CROE, Pierre Fabre, Toulouse, France Motors under Large Loads: Structural Aspects S. F. Raposo, R. Basto, D. St Johnston, J. W. Raff; of Kinetic Descriptions. D. Tsygankov, M. E. Gurdon Institute, Cambridge, United Kingdom 1436 B582 Identification of Novel Mitotic Fisher; IPST, University of Maryland, College Park, Regulatory Proteins Based on Biochemical MD 1426 B572 Dissecting Centriole and Assays and RNAi Screens. D. Ducat,1 S. Flagellar Assembly Using bld Mutants in Kawaguchi,1 H. Lu,2 J. Yates,2 Y. Zheng1; 1417 B563 Contribution of Filopodia to Cell Chlamydomonas. J. L. Feldman,1 S. Geimer,2 W. 1Department of Embryology, The Carnegie Migration: A Mechanical Link between F. Marshall1; 1Biochemistry, University of California, Institution of Washington and Howard Hughes Protrusion and Contraction. F. Xue, D. Janzen, San Francisco, San Francisco, CA, 2Biologie/ Medical Institute, Baltimore, MD, 2The Scripps D. A. Knecht; Molecular and Cell Biology, Elektronenmikroskopie, Universität Bayreuth, Research Institute, La Jolla, CA University of Connecticut, Storrs, CT Bayreuth, Germany 1437 B583 The TACC Domain of the 1418 B564 Cells Increase the Number and 1427 B573 Using Chlamydomonas Mutants Xenopus Protein, Maskin, Is Required for Adhesiveness of Their "Sticky Fingers" as They with Defects in Centriole Cohesion to Explore Centrosome Function. A. J. Albee, C. Wiese; Turn Toward Permissive Substrates. J. the Role of the Mother and Daughter Centriole Biochemistry, University of Wisconsin–Madison, Galbraith,1 C. Galbraith2; 1NINDS, National in the Cell. J. L. Feldman, W. F. Marshall; Madison, WI Institutes of Health, Bethesda, MD, 2NIDCR, Biochemistry, University of California, San National Institutes of Health, Bethesda, MD Francisco, San Francisco, CA 1438 B584 Centrosomin Motif 1 Regulates Microtubule Assembly at Centrosomes. J. 1419 B565 Generation of Actin-rich 1428 B574 Beta-catenin Is a Nek2 Zhang, T. L. Megraw; Pharmacology and Green Protrusions in Sea Urchin Coelomocytes That Substrate and Activates Centrosome Separation Center for Reproductive Biology Sciences, Concentrate the Arp2/3 Complex and Can in Mitosis. S. Bahmanyar,1 D. D. Kaplan,1 J. De University of Texas Southwestern Medical Center, Resemble Either Growth Cones or Comet Tails. Luca,2 E. D. Salmon,3 P. J. Casey,4 W. J. Nelson,1 Dallas, TX M. K. Voss,1 C. N. Lakin,1 L. H. Henson,2 M. D. A. I. M. Barth1; 1Stanford University, Stanford, CA, Lessard,3 J. Bewersdorf,3 J. H. Henson1; 1Biology, 2Colorado State, Fort Collins, CO, 3University of 1439 B585 Functional Analysis of the Dickinson College, Carlisle, PA, 2Biology, Oberlin North Carolina, Charlotte, NC, 4Duke University, Centrosomin Homologue CDK5RAP2. J. A. College, Oberlin, OH, 3Institute for Molecular 1 1 2 Durham, NC Barrera, L. R. Kao, R. E. Hammer, T. L. Biophysics, The Jackson Laboratory, Bar Harbor, Megraw1; 1Pharmacology/Green Center for ME 1429 B575 Chromatin Remodeling Proteins Reproductive Biology Sciences, UT Southwestern Interact with Pericentrin to Regulate Medical Center, Dallas, TX, 2Biochemistry/Green 1420 B566 Cell Blebs Inhibit Initial Centrosome Integrity. J. E. Sillibourne, B. Delaval, Center for Reproductive Biology Sciences, UT Spreading of Endothelial Cells. L. Matta,1 R. S. D. Redick, M. Sinha, S. J. Doxsey; Program in Southwestern Medical Center, Dallas, TX Oetama,1 K. Sengupta,2 H. Aranda-Espinoza1; 1 Molecular Medicine, University of Massachusetts Fischell Department of Bioengineering, University 1440 B586 Human Cep192 Is Required for 2 Medical School, Worcester, MA of Maryland, College Park, MD, Campus de the Assembly and Function of Mitotic Luminy, Marseille, France 1430 B576 Depletion of Lamin and Lamin- Centrosomes. M. A. Gomez-Ferreria,1 D. Rines,2 binding Proteins Causes a Novel Centrosome D. J. Sharp1; 1Physiology and Biophysics, Albert 1421 B567 The Effect of Cholesterol on the Attachment Phenotype. Z. Gao,1 J. Liu,2 D. A. Einstein College of Medicine, Bronx, New York, NY, Traction Force and Adhesion Area of Starr,2 C. J. Malone1; 1Department of Biochemistry 2Genomics Institute of the Novartis Research Endothelial Cells. R. J. Oetama,1 M. Dembo,2 D. 3 4 1 and Molecular Biology, The Pennsylvania State Foundation, San Diego, CA Hammer, I. Levitan, H. Aranda-Espinoza ; 2 1 2 University, University Park, PA, Molecular and University of Maryland, College Park, MD, Boston 1441 B587 CPAP Is a Centriole-associated 3 Cellular Biology, University of California, Davis, University, Boston, MA, University of Protein Required for Centriole Formation in 4 Davis, CA Pennsylvania, Philadephia, PA, University of Human Cells. G. Kohlmaier, P. Gönczy; Swiss Illinois at Chicago, Chicago, IL 1431 B577 Dissecting the Centriole Institute for Experimental Cancer Research Proteome. L. C. Keller,1 S. Geimer,2 E. Romijn,3 J. (ISREC), Lausanne, Switzerland 4 1 1 Centrosomes R. Yates, W. Marshall ; Biochemistry, University of California, San Francisco, San Francisco, CA, 1442 B588 Characterization of CEP72, a 2Universitat Bayreith, Bayreuth, Germany, Novel Centrosome Protein. S. Kim, K. Rhee; 1422 B568 What Does Evolution Tell Us 3Biochemistry, The Scripps Research Institute, La School of Biological Sciences, Seoul National About Centriole Duplication? Z. Carvalho- Jolla, CA, 4The Scripps Research Institute, La University, Seoul, Republic of Korea Santos, M. Bettencourt-Dias, J. B. Pereira-Leal; Jolla, CA Instituto Gulbenkian de Ciência, Oeiras, Portugal 1432 B578 Dynamics of Core Centriole Microtubule Dynamics and Assembly Components SAS-4 and SAS-6 Define Two Sequential Steps in Centriole Assembly. A. 1443 B589 NEK7 Is a Centrosomal Kinase Dammermann, A. Desai, K. Oegema; Ludwig Critical for Microtubule Nucleation. S. Kim, K. Institute for Cancer Research, University of Lee, K. Rhee; School of Biological Sciences, Seoul California, San Diego, La Jolla, CA National University, Seoul, Republic of Korea

122 The American Society for Cell Biology 47th Annual Meeting MONDAY December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org Poster Session 2 B590–B616

1444 B590 ␥-Tubulin Binds Transiently to 1452 B598 Regulation of In Vitro 1461 B607 Microtubule Polymerization the Mitotic Spindle Differing from Centrosomes. Microtubule Dynamics by the Autonomous Rates Correlate with Treatments That Affect M. A. Hallen, J. Ho, C. D. Yankel, S. A. Endow; Microtubule-End Tracker Mal3p. E. Munteanu, L. Neurite Outgrowth in PC12 Cells. T. N. Kelly,1 I. Cell Biology, Duke University Medical Center, Laan, M. Dogterom; Bio-Assembly and Chen,2 T. Thach,3 Y. Katagiri,3 J. S. Urbach,1 H. M. Durham, NC Organization, FOM Institute AMOLF, Amsterdam, Geller3; 1Physics, Georgetown University, The Netherlands Washington, DC, 2Biomedical Engineering, Georgia 1445 B591 Tension Applied through the Institute of Technology, Atlanta, GA, 3National Dam1 Kinetochore Complex Promotes 1453 B599 Dynamics of Force Generating Heart, Lung and Blood Institute, National Institutes Elongation of Individual Microtubules: A Direct Microtubules In Vitro in the Presence of Fission of Health, Bethesda, MD Mechanism for Length Control in Mitosis. C. L. Yeast End-tracking Proteins Mal3, Tea2, and Asbury,1 A. D. Franck,1 A. F. Powers,1 D. R. Tip1. L. Laan,1 L. Munteanu,1 I. M. Tharun,1 P. 1462 B608 Evidences of Nitric Oxide Gestaut,2 T. Gonen,2 T. N. Davis2; 1Physiology and Bieling,2 T. Surrey,2 D. Brunner,2 M. Dogterom1; Signaling via Microtubules in Arabidopsis Root Biophysics, University of Washington, Seattle, WA, 1FOM Institute AMOLF, Amsterdam, The Cells. A. I. Yemets,1 Y. A. Sheremet,1 Y. B. 2Biochemistry, University of Washington, Seattle, Netherlands, 2EMBL, Heidelberg, Germany Blume2; 1Cell Biology and Biotechnology, Institute WA of Cell Biology and Genetic Engineering, Kiev, 1454 B600 Interplay between MARKK/TAO- Ukraine, 2Genomics and Biotechnology, Institute of 1446 B592 The Drosophila Homolog of 1 and Two Novel Interaction Partners Spred1 Cell Biology and Genetic Engineering, Kiev, Tubulin Folding Co-Factor E, CG7861, and TESK1 Influences the Organisation of the Ukraine Influences the Organization and Function of Microtubule and F-Actin Cytoskeleton. C. Johne, Interphase and Mitotic Microtubules. S. D. Matenia, T. Timm, E. Mandelkow; Structural 1463 B609 Computer Vision Based Tools Mukherjee, D. Sharp; Physiology and Biophysics, Molecular Biology, Max-Planck Unit, Hamburg, for the Analysis of Microtubule Dynamic Albert Einstein College of Medicine of Yeshiva Germany Instability. A. Altinok,1 E. Sargin,1 E. Kiris,2 L. University, Bronx, NY Wilson,2 S. C. Feinstein,2,3 B. Manjunath,1 K. 1455 B601 Spatial Regulation of Rose1; 1Electrical and Computer Engineering, 1447 B593 MCAK Is Critical for Controlling Microtubule Dynamics in Fission Yeast. C. University of California Santa Barbara, Santa 1 2 1 1 Mitotic Microtubule Distribution at Nuclear Tischer, D. Brunner, M. Dogterom ; AMOLF, Barbara, CA, 2Molecular, Cellular and 2 Envelope Breakdown. R. S. Rizk, K. P. Amsterdam, The Netherlands, EMBL, Heidelberg, Developmental Biology, University of California Bohannon, J. A. Powers, S. L. Shaw, C. E. Germany Santa Barbara, Santa Barbara, CA, 3Neuroscience Walczak; Biology, Indiana University Bloomington, Research Institute, University of California Santa Bloomington, IN 1456 B602 Microtubule Acetylation Inhibits Focal Adhesion Targeting and Turnover. A. Tran, Barbara, Santa Barbara, CA 1448 B594 ICIS Regulates Kif2a to Control E. I. Finkelstein, J. Bulinski; Biological Sciences, 1464 B610 FtsZ (with a Membrane Microtubule Dynamics and Bipolar Spindle Columbia University, New York, NY Targeting Sequence) Can Assemble Z Rings 1 2 2 Formation. W. Lan, V. Vorozhko, J. Daum, A. and Spirals In Vivo, and Tubulate Membranes In 1 2 1 1457 B603 Influence of Tubulin Isotype Knowlton, G. J. Gorbsky, T. Stukenberg ; Vitro. M. Osawa, H. P. Erickson; Cell Biology, 1Biochemistry and Molecular Genetics, University Composition on the Dynamic Properties of 1 Duke University Medical Center, Durham, NC of Virginia, Chalrlottesville, VA, 2Molecular Cell and Microtubules: A Quantitative Study. V. Rezania, 2 2 3 Developmental Biology, Oklahoma Medical O. Azarenko, M. Jordan, H. Bolterauer, R. 1465 B611 Assembly of FlpX, an FtsZ-like 4 1 1 1 Research Foundation, Oklahoma City, OK Luduena, T. Huzil, J. Tuszynski ; Division of Protein from pXO1 Plasmid of Bacillus Experimental Oncology, University of Alberta, anthracis. Y. Chen, H. P. Erickson; Cell Biology, 2 1449 B595 Effects of Combinatorial Tau Edmonton, AB, Canada, Department of Molecular, Duke University Medical Center, Durham, NC Pseudophosphorylation upon Microtubule Cellular and Developmental Biology, University of Binding, Assembly, and the Regulation of California, Santa Barbara, Santa Barbara, CA, Dynamic Instability In Vitro. E. Kiris,1,2,3 M. R. 3Institute of Theoretical Physics, J. Liebig Cell Motility - Regulation II Gaylord,1,3 J. Reifert,1,3 A. Altinok,2,4 M. E. Universitaet Giessen, Giessen, Germany, Sargin,2,4 K. Rose,2,4 B. S. Manjunath,2,4 M. A. 4Department of Biochemistry, University of Texas 1466 B612 Neutrophil Adhesion and Jordan,3 L. Wilson,1,2,3 S. C. Feinstein1,2,3; Health Science Center at San Antonio, San Migration Are Mediated by Matrix Rigidity. D. 1Neuroscience Research Institute, University of Antonio, TX Paranhos Zitterbart,1 P. Oakes,2 N. Morin,3 B. California, Santa Barbara, Santa Barbara, CA, Fabry,1 J. Reichner,3 J. X. Tang2; 1Department of 2 1458 B604 RRM Domain Proteins and Center for BioImage Informatics, Santa Barbara, Physics, University of Erlangen-Nuermberg, 3 Spermatogenesis in Marsilea. C. M. Van der CA, Molecular, Cellular and Developmental Erlangen, Germany, 2Biophysics Lab, Brown Weele, S. M. Wolniak; Cell Biology and Molecular Biology, University of California, Santa Barbara, University, Providence, RI, 3Department of Surgery, 4 Genetics, University of Maryland–College Park, Santa Barbara, CA, Electrical and Computer Brown Medical School, Providence, RI Engineering, University of California, Santa College Park, MD 1467 B613 Force Generation during Barbara, Santa Barbara, CA 1459 B605 Protein Kinase-Protein Interstitial Leukocyte Chemotaxis. M. Sixt, T. Phosphatase Interplay Modulates Organization 1450 B596 The Formin mDia2 Stabilizes Lämmermann; Molecular Medicine, Max Planck Microtubules Independently of Its Actin of Cortical Microtubules in Arabidopsis Root 1 1 2 Institute, Martinsried, Germany Nucleation Activity. F. Bartolini,1 J. B. Moseley,2 J. Cells. Y. A. Sheremet, A. I. Yemets, J. Verbelen, 3 1 Schmoranzer,1 L. Cassimeris,3 B. L. Goode,4 G. G. Y. B. Blume ; Department of Cell Biology and 1468 B614 Effects of Substrate Compliance Gundersen1; 1Anatomy & Cell Biology and Biotechnology, Institute of Cell Biology and Genetic on Neutrophil Motility. K. Stroka, H. Aranda- 2 Pathology, Columbia University, New York, NY, Engineering, Kiev, Ukraine, Department of Biology, Espinoza; Fischell Department of Bioengineering, 2Yeast Genetics and Cell Biology, Rockefeller University of Antwerpen, Antwerpen, Belgium, University of Maryand, College Park, MD 3 University, New York, NY, 3Lehigh University, Department of Genomics and Biotechnology, Bethlehem, PA, 4Biology and Rosenstiel Basic Institute of Cell Biology and Genetic Engineering, 1469 B615 SSX-New Molecular Target Medical Sciences Research Center, Brandeis Kiev, Ukraine Regulating Cancer Invasion. K. Itoh, N. Naka, K. University, Waltham, MA Yoshioka; Biology, Osaka Medical Center for 1460 B606 Microtubule Architecture Cancer, Osaka, Japan 1451 B597 Caspase-mediated Cleavage of Determines Shape Fluctuation Dynamics. K. Taute,1 F. Pampaloni,2 E. Florin1; 1Center for 1470 B616 The Contribution of PCPH to C53 Protein Disrupts Cytoplasm-Nucleus 1 Barrier during Apoptosis. J. Wu,1,2 H. Jiang,1 S. Nonlinear Dynamics, University of Texas at Austin, Colon Carcinoma Cell Motility. C. M. MacCarthy, 2 J. Villar,2 V. Notario1,2; 1Biochem. and Molecular & Luo,1 Y. Tang,1 L. Honglin1; 1Children's Memorial Austin, TX, Cell Biology and Biophysics Unit, 2 European Molecular Biology Laboratory, Cellular Biology, Georgetown University, Research Center, Chicago, IL, The Feinberg 2 School of Medicine, Northwestern University, Heidelberg, Germany Washington, DC, Radiation Medicine, Georgetown University, Washington, DC Chicago, IL

123 MONDAY The American Society for Cell Biology 47th Annual Meeting Poster Session 2 B617–B641 December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org

1471 B617 Defining Critical Shc 1478 B624 Both Bone Morphogenetic 1486 B632 A Biosensor of S100A4 Interactions in Cancer: Cross-Talk of Shc and Protein (BMP-2) and Wingless (Wnt 3a) Metastasis Factor Activation - Inhibitor HEF1 Signaling Pathways. E. Izumchenko,1 I. Simultaneously Activate Canonical B-Catenin Screening and Cellular Activation Dynamics. S. Serebriiskii,1 M. Wolfson,2 E. Golemis1; 1Basic Mediated Gene Regulation to Stimulate C. Garrett,1 N. Turner,1 A. Rybin,2 A. Toutchkine,3 Science, Fox Chase Cancer Center, Philadelphia, Endothelial Proliferation and Non-canonical K. M. Hahn,3 D. S. Lawrence,1 A. R. Bresnick1; PA, 2Microbiology and Immunology, Ben-Gurion Disheveled-Rho-Rac to Promote Motility. V. A. 1Biochemistry, Albert Einstein College of Medicine, University, Beer-Sheva, Israel de Jesus Perez,1 J. Axelrod,2 M. Amieva,3 M. Bronx, NY, 2Cell Biology, Albert Einstein College of Rabinovitch4; 1Pulmonary and Critical Care Medicine, Bronx, NY, 3Pharmacology, University 1472 B618 Use of Biosensors to Track the Medicine, Stanford University, Stanford, CA, North Carolina, Chapel Hill, NC Initiation of Cell Motility in Tumor Cells In Vitro 2Pathology, Stanford University, Stanford, CA, and In Vivo. J. van Rheenen, M. Oser, D. Kedrin, 3Infectious Diseases, Stanford University, Stanford, J. Wyckoff, H. Yamaguchi, W. van Roosmalen, J. CA, 4Pediatrics, Stanford University, Stanford, CA Kinetochores I Segall, J. Condeelis; Anatomy & Structural Biology, Albert Einstein College of Medicine, Bronx, NY 1479 B625 Ror2 Regulates Cytoskeletal 1487 B634 Definition of a Holocentromere. Rearrangements to Mediate Wnt5a-induced R. Gassmann,1 S. Ercan,2 P. Maddox,1 J. Lieb,2 A. 1473 B619 Rho/ROCK-dependent Caveolin- Polarized Cell Migration. A. Nomachi, M. Nishita, Desai1; 1Ludwing Institute for Cancer Research, La 1 Phosphorylation Regulates Focal Contact M. Enomoto, M. Hamasaki, Y. Minami; Physiology Jolla, CA, 2Department of Biology, The University Turnover and Tumor Cell Migration. B. Joshi,1 S. and Cell Biology, Kobe University, Kobe, Japan of North Carolina at Chapel Hill, Chapel Hill, NC S. Strugnell,1 J. Goetz,1 M. E. Cox,2 S. M. Wiseman,3,4 I. R. Nabi1; 1Cellular and Physiological 1480 B626 Capns1, a Novel Partner of 1488 B635 Centromere Capture by Sciences, University of British Columbia, RasGAP-SH3 Domain: Their Interaction Microtubules In Silico and In Vivo. A. Zidovska, Vancouver, BC, Canada, 2Prostate Cancer Centre, Modulates RasV12 Oncogenic Cell Migration. B. M. Mayer, A. Franck, C. Fu, M. Wang, H. Mueller, British Columbia Cancer Agency & University of Gril,1 P. Pamonsinlapatham,1 W. Thomas,2 F. R. Wollman, R. Vale, G. Goshima; Physiology British Columbia, Vancouver, BC, Canada, Raynaud,1 S. Dufour,3 R. Hadj-Slimane,1 C. Course 2007, Marine Biological Laboratory, Woods 3Pathology, Genetic Pathology Evaluation Centre, Garbay,1 M. Vidal1; 1Laboratoire de Hole, MA Vancouver General Hospital, British Columbia Pharmacochimie Moleculaire et Cellulaire, INSERM Cancer Agency & University of British Columbia, U648, Paris, France, 2Natural Sciences, Colby- 1489 B636 Centromeric Chromatin Vancouver, BC, Canada, 4Surgery, St. Paul’s Sawyer College, New London, NH, 3Institut Curie, Assembly Linked to DNA Repair. S. G. Zeitlin,1 Hospital & University of British Columbia, UMR144 CNRS, Paris, France B. R. Chapados,2 N. M. Baker,3 C. Tai,4 G. Vancouver, BC, Canada Slupphaug,5 M. W. Berns,3 D. W. Cleveland,1 J. J. 1481 B627 Calpain/␤-PIX Association Is Wang6; 1Cellular and Molecular Medicine, 1474 B620 Fer-mediated Cortactin Involved in Invadopodia Formation. T. R. University of California, San Diego, La Jolla, CA, Phosphorylation Is Dependent on Reactive Dowler,1 V. Singh,1 S. Angers,2 P. Greer,3 Z. Jia,1 2Molecular Biology, TSRI, La Jolla, CA, Oxygen Species Generation during Integrin- A. Mak1; 1Biochemistry, Queen's University, 3Bioengineering, University of California, San mediated Cell Adhesion and Is Associated with Kingston, ON, Canada, 2Leslie Dan Faculty of Diego, La Jolla, CA, 4Biology, University of Efficient Fibroblast Migration. W. Sangrar,1 Y. Pharmacology, University of Toronto, Toronto, ON, California, San Diego, La Jolla, CA, 5Faculty of Gao,1 M. Scott,2 P. Truesdell,1 P. A. Greer1; Canada, 3Division of Cancer Biology and Genetics, Medicine, NTNU, Trondheim, Norway, 1Pathology and Molecular Medicine, Queen's Queen's University Cancer Research Institute, 6Moores–UCSD Cancer Center, University of University, Kingston, ON, Canada, 2Biochemistry, Kingston, ON, Canada California, San Diego, La Jolla, CA Queen's University, Kingston, ON, Canada 1482 B628 The Intermediate Filament- 1490 B637 Cytoplasmic Dynein 1475 B621 Nitric Oxide Mediated Changes associated Protein BP230 (BPAG1) Regulates Dephosphorylation Functions as a Molecular in Membrane Microviscosity Are Rate Limiting Cofilin Activation and Keratinocyte Motility Switch in the Spindle Assembly Checkpoint. J. for Endothelial Cell Migration and Endocytosis. Behavior. K. J. Hamill, J. C. Jones; Cell and Bader, J. Whyte, S. Tauhata, M. Raycroft, P. C. Grote-Westrick, R. Heumann; Molecular Molecular Biology, Northwestern University, Vaughan, J. Hornick, E. Hinchcliffe, K. T. Vaughan; Neurobiochemistry, Ruhr University Bochum, Chicago, IL Biological Sciences, University of Notre Dame, Bochum, Germany Notre Dame, IN 1483 B629 A New Role for Extracellular 1476 B622 Essential Roles of ERK- Heat Shock Protein-90alpha (hsp90a): 1491 B638 Defining the Requirements for mediated Phosphorylation of Vinexin in Cell Promoting Skin Cell Motility and Wound Spindle Checkpoint Activation Using Controlled Spreading, Migration, and Anchorage- Healing. W. Li; University of Southern California, Monopolar Spindle Formation in C. elegans independent Growth. K. Nagata,1 K. Mizutani,2 H. Los Angeles, CA Embryos. A. W. Essex,1 A. Dammermann,2 P. Ito,1 I. Iwamoto,1 R. Morishita,1 T. Deguchi,2 Y. Maddox,2 I. Cheeseman,2 K. Oegema,2 A. Desai2; 3 1 1 1484 B630 Multiple Mechanisms for the Nozawa, T. Asano ; Molecular Neurobiology, 1Biomedical Sciences, University of California, San Regulation of Myosin-IIA Assembly: S100A4 Institute for Developmental Research, Aichi Human Diego/Ludwig Institute for Cancer Research, San Service Center, Kasugai, Japan, 2Department of Binding and Heavy Chain Phosphorylation. R. 2 1 1 2 Diego, CA, Ludwig Institute for Cancer Research, Urology, Gifu University School of Medicine, Gifu, P. House, N. G. Dulyaninova, E. L. Snapp, A. R. 1 1 San Diego, CA Japan, 3Molecular Neurobiology, Gifu International Bresnick ; Biochemistry, Albert Einstein College of 2 Institute of Biotechnology, Gifu, Japan Medicine, Bronx, NY, Anatomy and Structural 1492 B639 Structure-Function Analysis of Biology, Albert Einstein College of Medicine, Bronx, Bub1 in the Control of Spindle Checkpoint and 1477 B623 Loss of Vinexin Expression NY Chromosome Attachment. P. Meraldi, C. Klebig, Impairs the Wound Healing In Vitro and In Vivo. R. Holtackers; Biochemistry, ETH Zurich, Zurich, N. Kioka,1 T. Itoh,1 T. Umemoto,1 N. Uekawa,2 M. 1485 B631 S100A4 Regulates Macrophage 1 1 1 Switzerland Yamada,2 H. Imai,2 K. Ueda1; 1Graduate School of Motility. Z. Li, N. G. Dulyaninova, M. Pozzuto, F. 2 3 1 Agriculture, Division of Applied Life Sciences, J. Pixley, M. Cammer, S. C. Almo, A. R. 1493 B640 Blinkin Ensures Spindle 1 1 Kyoto University, Kyoto, Japan, 2Graduate School Bresnick ; Biochemistry, Albert Einstein College of Checkpoint and Correct Chromosome 2 of Agriculture, Division of Applied Biosciences, Medicine, Bronx, NY, School of Medicine and Segregation by Recruiting Bub1 and BubR1 to Kyoto University, Kyoto, Japan Pharmacology, University of Western Australia, Kinetochores. T. Kiyomitsu, C. Obuse, M. Crawley, Australia, 3Analytical Imaging Facility, Yanagida; Biostudies Kyoto University, Kyoto, Albert Einstein College of Medicine, Bronx, NY Japan

1494 B641 Imbalanced Expression and Mis- localization of Histone H3 and Its Variant Cse4p Lead to Defects in Chromosome Transmission Fidelity. W. Au,1 S. DeLuca,1 M. Crisp,1 O. Rando,2 M. A. Basrai1; 1Genetics, National Cancer Institute, Bethesda, MD, 2Biochemistry and Molecular Pharmacology, University of Massachusetts, Worcester, MA

124 The American Society for Cell Biology 47th Annual Meeting MONDAY December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org Poster Session 2 B642–B670

1495 B642 Kinetochores Control Spindle 1505 B652 Temporal Regulation of 1515 B662 Probing Protein Interactions in Bipolarity during Prometaphase via MCAK. J. R. HsCdc14A by PLK1 Is Essential for Mitotic Living Yeast with Fluorescence Correlation Winter,1 A. Toso,2 P. Meraldi,2 A. D. McAinsh1; Progression. K. Yuan,1,2 A. Shaw,1 T. Ward,1 X. Spectroscopy (FCS). S. K. Trautmann,1 J. Ries,2 1Chromosome Segregation Laboratory, Marie Curie Yao1,2; 1Physiology, Morehouse School of P. Schwille,2 Y. Barral1; 1Biology, Institute of Research Institute, Oxted, United Kingdom, Medicine, Atlanta, GA, 2Cellular Dynamics, Hefei Biochemistry, ETH Zurich, Zurich, Switzerland, 2Institute of Biochemistry, ETH Zurich, Zurich, National Laboratory for Physical Sciences, Hefei, 2Biophysics, Technical University Dresden, Switzerland China Dresden, Germany

1496 B643 The Kinetochore Consortium at 1506 B653 Synchronizing Chromosome 1516 B663 What Determines Mitotic Spindle MBL. C. Allan, A. C. Amaro, J. F. Dorn, K. Segregation. I. Matos,1 A. J. Pereira,1 S. Length? G. Greenan, M. Breckenridge, N. Minc, H. Jaqaman, E. M. King, J. Kunken, I. M. Porter, M. Moutinho-Pereira,1 L. A. Cameron,2 E. D. Salmon,2 Müller, K. Newell-Litwa, D. Wu, F. Jülicher, A. Posch, J. R. Winter, G. Danuser, A. D. McAinsh, P. H. Maiato1; 1Institute for Molecular and Cell Hyman; Marine Biological Laboratory, Physiology Meraldi, J. J. Swedlow, J. R. Swedlow; Marine Biology, Porto, Portugal, 2Department of Biology, Course 2007, Woods Hole, MA Biological Laboratory, Woods Hole, MA University of North Carolina, Chapel Hill, NC 1517 B664 Tension Applied through the 1497 B644 The Purification and 1507 B654 Inheritance of the Golgi Ribbon Dam1 Complex Promotes Microtubule Characterization of Yeast Kinetochores. B. Is Dependent on the Mitotic Spindle. J. Wei, J. Elongation Providing a Direct Mechanism for Akiyoshi,1 J. Ranish,2 S. Biggins1; 1Basic Sciences, Seemann; Cell Biology, UT Southwestern Medical Length Control in Mitosis. A. F. Powers,1 A. D. Fred Hutchinson Cancer Research Center, Seattle, Center, Dallas, TX Franck,1 D. R. Gestaut,2 T. Gonen,2 T. N. Davis,2 WA, 2Institute for Systems Biology, Seattle, WA C. L. Asbury1; 1Physiology & Biophysics, University 1508 B655 Kinesin-5 Motors Mediate of Washington, Seattle, WA, 2Biochemistry, 1498 B645 Molecular Architecture of the Chromosome Alignment during Mitosis by University of Washington, Seattle, WA Budding Yeast Kinetochore Using In Vivo K- Promoting Depolymerization of Longer SHREC. A. Joglekar, K. Bloom, E. Salmon; Microtubules. M. K. Gardner,1 D. C. Bouck,2 L. V. 1518 B665 Dynamic Asymmetric University of North Carolina–Chapel Hill, Chapel Paliulis,2 J. B. Meehl,3 E. T. O'Toole,3 A. P. Localization of LIN-5 and GPR for Asymmetric Hill, NC Joglekar,2 M. Winey,3 E. D. Salmon,2 K. Bloom,2 D. Spindle Positioning in C. elegans One-Cell J. Odde1; 1Biomedical Engineering, University of Embryos. D. Park, L. S. Rose; Molecular and 1499 B646 A View of Kinetochore Protein Minnesota, Minneapolis, MN, 2Biology, University of Cellular Biology, University of California, Davis, Architecture from the Ndc80 Complex Using K- North Carolina, Chapel Hill, NC, 3MCD Biology, Davis, CA 1 1 1 SHREC. X. Wan, R. P. O'Quinn, H. L. Pierce, J. University of Colorado, Boulder, CO Polka,1 J. G. DeLuca,2 A. Desai,3 S. Liu,4 T. Yen,4 1519 B666 PPH-6 and PAR-4 Modulate P. T. Stukenberg,5 S. S. Taylor,6 E. D. Salmon1; 1509 B656 Huntingtin Is a New Regulator Pulling Forces by Affecting Phosphorylation 1Biology, University of North Carolina, Chapel Hill, of Spindle Orientation during Mitosis. K. States of GPR-1/2 during Asymmetric Spindle NC, 2Biochemistry and Molecular Biology, Colorado Colombo-Maurat,1 B. C. Charrin,1 L. Nguyen,2 J. Positioning of C. elegans Embryos. K. Afshar,1,2 State University, Fort Collins, CO, 3Ludwig Institute Dompierre,1 S. L. Anne,1 F. Guillemot,2 S. M. Larsen,3 P. Gönczy1,2; 1Swiss Institute For for Cancer Research, University of California, San Humbert,1 F. Saudou1; 1Institut Curie - UMR146 Experimental Cancer Research, Epalinges, Diego, La Jolla, CA, 4Fox Chase Cancer Center, CNRS, Orsay, France, 2Division of Molecular Switzerland, 2Life Science, Swiss Federal Institute Philadelphia, PA, 5School of Medicine, University of Neurobiology, National Institute for Medical of Technology(EPFL), Lausanne, Switzerland, Virginia, Charlottesville, VA, 6Faculty of Life Research, Mill Hill London, United Kingdom 3Department of Biochemistry and Molecular Sciences, University of Manchester, Manchester, Biology, University of Southern Denmark, Odense, United Kingdom 1510 B657 Individual Microtubules in Denmark Spindles Turnover by Dynamic Instability. D. J. Needleman,1 A. Groen,1 O. Ryoma,1 L. Mirny,2 T. 1520 B667 Cortical Granule Exocytosis in Mitosis and Meiosis II Mitchison1; 1Systems Biology, Harvard, Boston, C. elegans Is Regulated by Cell Cycle MA, 2Physics and Harvard-MIT Division of Health Components Including Separase. J. N. 1500 B647 Biophysical Properties of Mitotic Sciences and Technology, MIT, Boston, MA Bembenek,1 C. T. Richie,2 J. M. Squirrell,1 J. M. Asters Formed in Human Mitotic Extracts. S. Campbell,1 K. W. Eliceiri,1 D. Poteryaev,3 A. 1511 B658 New Insights into Bipolar 3 2 1 1 Kollu,1 B. Charlebois,2 H. T. Schek,2 A. J. Hunt,2 D. Spang, A. Golden, J. G. White ; Molecular Spindle Formation through Altered Protein 2 A. Compton1; 1Biochemistry, Dartmouth Medical Biology, UW Madison, Madison, WI, Laboratory of 2 Complexes at the Microtubule Organizing Biochemistry and Genetics, NIDDK, National School, Hanover, NH, Biomedical Engineering, 1 2 3 Center. A. Rodriguez, J. Batac, A. Killilea, J. Institutes of Health, Bethseda, MD, 3Growth & University of Michigan, Ann Arbor, MI 4 4 4 1 Allen, I. Lin, J. L. Paluh ; Department of Development, Biozentrum, University of Basel, 1501 B648 Organization of the Yeast Medicine, New York University School of Medicine, Basel, Switzerland Metaphase Spindle. E. Marco,1 J. F. Dorn,2 K. NY, 2Tufts University School of Medicine, Boston, Jaqaman,2 G. Danuser,2 P. K. Sorger1; MA, 3Lawrence Berkeley Labs, University 1Department of Systems Biology, Harvard Medical California, Berkeley, Berkeley, CA, 4Biology, CBIS, Oncogenes and Tumor Suppressors I School, Boston, MA, 2Department of Cell Biology, Rensselaer Polytechnic Institute, Troy, NY The Scripps Research Institute, La Jolla, CA 1521 B668 Differential DNA Binding of p53 1512 B659 Identification of a Novel Cell from Human Cell Lines to Unique Gene Cycle-regulated Gene Involved in Maintaining 1502 B649 The Yeast Hex3•Slx8 Sequences. S. Gal, U. Chandrachud; Biological Spindle Bipolarity. L. K. George, M. L. Whitfield; Heterodimer is a Ubiquitin Ligase Stimulated by Sciences, Binghamton University, Binghamton, NY Substrate Sumoylation. O. Kerscher,1 Y. Xie,2 M. Genetics, Dartmouth Medical School, Hanover, NH Kroetz,2 H. F. McConchie,1 P. Sung,2 M. 1522 B669 c-Met Mutant Induces Genomic 1513 B660 Functional Characterization of Hochstrasser2; 1Biology, College of William & Mary, Instability in a p53-dependent Manner and via TPX2. P. Wadsworth,1 K. Moody,1 C. Fagerstrom,1 Williamsburg, VA, 2Molecular Biophysics & Decrease of Mitotic Checkpoint Activity. H. M. Schvarzstein,2 A. Wilde2; 1Biology, University of Biochemistry, Yale University, New Haven, CT Nam,1,2 S. Jang,1,2 J. Lee1,2; 1Biochemistry and Massachusetts, Amherst, MA, 2Medical Genetics Molecular Biology, Ajou University School of and Microbiology, University of Toronto, Toronto, 1503 B650 The Grp/Chk1-dependent Medicine, Suwon, Republic of Korea, 2Department ON, Canada Checkpoint Protects the Nucleus from Active of Molecular Science and Technology, Ajou Cytoplasmic Cyclin B/Cdk1 by Delaying Cyclin 1514 B661 Titration of the Spindle University, Suwon, Republic of Korea B Import in Drosophila Embryo. A. Royou; Assembly Checkpoint in Early Embryonic Cells. Molecular, Cell and Developmental Biology, 1523 B670 The Nucleolus and the Cell J. Kreher, D. Miranda, C. B. Shuster; Biology, New University of California at Santa Cruz, Santa Cruz, Cycle: Nucleophosmin Is a Binding Partner of Mexico State University, Las Cruces, NM CA Nucleostemin in Human Tumor Cells, Independent of the Nucleophosmin-interactive 1504 B651 Identifying Novel Spindle Tumor Suppressor ARF. H. Ma, T. Pederson; Proteins in Saccharomyces cerevisiae. B. E. Biochemistry and Molecular Pharmacology, Keyes; Biochemistry and Molecular Genetics, University of Massachusetts Medical School, University of Virginia, Charlottesville, VA Worcester, MA

125 MONDAY The American Society for Cell Biology 47th Annual Meeting Poster Session 2 B671–B699 December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org

1524 B671 Degradation of HIPK2 and 1534 B681 Enhanced Cyclin D1, Cyclin E1, 1543 B690 Telomeres, Telomere Crisis, and Mdm2 in Response to Environmental Stimuli. L. Cyclin E2 and CDK6 Expression in Canine Telomere-linked RecQ Helicases in Aspergillus Deresa, C. Choi; Department of Biological Science, Mammary Tumor Cells is Frequent and nidulans. S. Mallareddy,1 D. W. Perry,1 M. Sungkyunkwan University, Suwon, Republic of Independent of Tumor Suppressor p16/INK4A Farman,2 P. M. Mirabito1; 1Biology, University of Korea Expression Defects. R. Bird, P. DeInnocentes, P. Kentucky, Lexington, KY, 2Plant Pathology, Agarwal, J. P. Herman, W. H. Morris; Pathobiology, University of Kentucky, Lexington, KY 1525 B672 Characterization of Domain of Auburn University, Auburn, AL Interaction between Human p53 and Human 1544 B691 When DNA Replication Stops. C. Sin3B Using Yeast Two Hybrid Assays. N. 1535 B682 Functional Characterization of Arrigo; Biology, New Jersey City University, Jersey Bansal, L. Vig, V. Brahmachari, D. Saluja; SUMOylation of TIP60 in UV-irradiated DNA City, NJ University of Delhi, Dr. B.R. Ambedkar Center for Damage Response. Q. Wu,1 Z. Cheng,2 X. Ding,1 Biomedical Research, Delhi, India F. Yan,1 X. Yao1; 1Physiology, Morehouse School 1545 B692 Identification of FOXM1 Targets of Medicine, Atlanta, GA, 2University of Science & in a Genome-wide Analysis of Periodic Gene 1526 B673 The Role of TRIM29 as a Tumor Technology of China, Hefei, China Expression. G. D. Grant, J. J. Parker, M. L. Suppressor Gene in Breast Cancer. J. Liu, P. Whitfield; Genetics, Dartmouth Medical School, Bernard; Huntsman Cancer Institute, Salt Lake 1536 B683 Cancer Cells Are Hypersensitive Hanover, NH City, UT to Structure Specific DNA Repair Inhibitors. S. Patra, A. M. Segall; Biology, San Diego State 1546 B693 The Centrosome-associated 1527 B674 Squalene Inhibits ATM Protein University, San Diego, CA Nucleocytoplasmic Shuttling Protein Cyclin G2 Kinase in Cells Following DNA Damage through Is Upregulated Downstream of Senescence- the Induction of Wip1. H. Nishida,1 N. Tatewaki,1 1537 B684 Genome-wide Analysis of inducing Stress Signals and Modulates Y. Nakajima,1 T. Konishi,1 N. Ikekawa2; 1Applied TOP3A-targeting Genes: Action on Checkpoint Responses. A. S. Arachchige Don, C. Life Sciences, Niigata University of Pharmacy and Transcriptional Programs Related to Cowan, R. Dallapiazza, M. Wong, M. Alvarez, M. Applied Life Sciences, Niigata, Japan, 2Niigata Bio Tumorigenesis. M. Hsieh,1 C. Lee,2 H. Chang,1 J. Horne; Pharmacology, University of Iowa, Iowa Research Center, Niigata, Japan Fan,1 T. Li1; 1Department and Graduate Institute of City, IA Microbiology, College of Medicine, National Taiwan 1528 B675 Functional Modification of University, Taipei, Taiwan, 2Division of Cancer 1547 B694 A Novel Role for the Human HIPK2 by SUMO-1 and Its Localization to PML Research, National Health Research Institute, Nup107-160 Nuclear Pore Sub-Complex in Cell 1 2 1 Nuclear Bodies. K. Sung, Y. Lee, C. Choi; Taipei, Taiwan Division. M. Zuccolo, E. Dultz, A. Alves, E. Department of Biological Science, Sungkyunkwan Formstecher,3 T. J. Yen,4 J. Sibarita,1 J. Ellenberg,2 University, Suwon, Republic of Korea V. Doye1; 1Umr144-cnrs, Institut Curie, Paris, Cell Cycle Stages France, 2Gene Expression Unit, European 1529 B676 The Tumor Suppressor DAPK Is Molecular Biology Laboratory, Heidelberg, Reciprocally Regulated by Tyrosine Kinase Src 3 4 1538 B685 Does Cdk6 Influence Cell Germany, HYBRIGENICS SA, Paris, France, Fox and Phosphatase LAR. W. Wang,1 J. Kuo,1 W. Migration through Integrin Pathways? M. J. Chase Cancer Center, Philadelphia, PA Ku,2 Y. Lee,2 F. Lin,1 Y. Chang,3 Y. Lin,4 C. Chen,1 Grossel, T. Baker; Connecticut College, New Y. Huang,1 M. Chiang,1 S. Yeh,1 P. Wu,2 C. Shen,2 London, CT C. Wu,3 R. Chen1,2; 1Institute of Biological Signal Transduction II Chemistry, Academia Sinica, Taipei, Taiwan, 1539 B686 Evaluation of Click Chemistry 2Institute of Molecular Medicine, College of Based Alternative to BrdU Antibody Labeling in 1548 B695 Coupling of Inositol Medicine, National Taiwan University, Taipei, Tissue and Cultured Cells Using Fluorescent Pyrophosphates Signal and High Energy Taiwan, 3Department of Pathology, College of Microscopy and Flow Cytometry. S. T. Clarke,1 Balance Is Independent of AMP-activated Medicine, National Taiwan University, Taipei, D. Hill,1 J. A. Bradford,1 Y. Chen,1 A. Salic,2 M. Protein Kinase. E. Mollapour,1 K. Choi,2 S. Taiwan, 4Institute of Biochemical Sciences, Hertel,3 R. Lakshmanaswamy4; 1Molecular Probes, Shears1; 1NIEHS/NIH, Research Triangle Park, NC, National Taiwan University, Taipei, Taiwan Eugene, OR, 2Cell Biology, Harvard Medical 2University of Texas MD Anderson Cancer Center, School, Boston, MA, 3Laboratory of Animal Houston, TX 1530 B677 IFN-␥ Enhances the Induction of Behavior, The Rockefeller University, New York, Cell Death by Heat-shock and Cisplatin through NY, 4Pathology, Texas Tech University, El Paso, TX 1549 B696 Glycolitic Flux Signals to mTOR Hsp27 Down-Regulation. M. Oba, S. Yano, T. Pathway through GAPDH-mediated Inhibition of Shuto, M. Suico, H. Kai; Department of Molecular 1540 B687 Coupling of DNA Binding and Rheb GTPase. M. Lee, J. Kim, A. Koh, S. Ha, C. Medicine, Graduate School of Pharmaceutical Helicase Activity Is Mediated by a Conserved Lee, J. Kim, P. Suh, S. Ryu; POSTECH, Pohang, Sciences, Kumamoto University, Kumamoto, Japan Loop in the MCM Protein. N. Sakakibara, Z. Republic of Korea Kelman; Center for Advanced Research in 1531 B678 Phosphorylation of PTEN's Biotechnology, University of Maryland 1550 B697 Systematic Analysis of Carboxy-terminus Regulates Membrane Biotechnology Institute, Rockville, MD Crosstalk in the PDGF Receptor Signal Localization. M. Rahdar,1,2 F. Vazquez,3 J. Transduction Network. C. Wang, C. Murat, J. Zhang,2 P. N. Devreotes1; 1Cell Biology, Johns 1541 B688 Identification of Dominant Haugh; Chemical and Biomolecular Engineering, Hopkins School of Medicine, Baltimore, MD, Negative Helicase Mutants by Insertional North Carolina State University, Raleigh, NC 2Pharmacology and Molecular Sciences, Johns Mutagenesis of the Yeast Replicative Helicase Hopkins School of Medicine, Baltimore, MD, Mcm2-7. F. J. Sanchez-Rivera,1 V. Tsakraklides,2 1551 B698 A 3D Model of Calcium 3Cancer Biology, Dana-Farber Cancer Institute and S. P. Bell2,3; 1University of Puerto Rico–Mayaguez, Signaling in Cerebellar Purkinje Cells. S. Brown, Harvard Medical School, Boston, MA Mayaguez, Puerto Rico, 2Biology, Massachusetts J. Watras, F. Morgan, L. Loew; Center for Cell Institute of Technology, Cambridge, MA, 3Howard Analysis & Modeling (CCAM), University of 1532 B679 Regulation of the Tumor Hughes Medical Institute, Cambridge, MA Connecticut Health Center, Farmington, CT Suppressor LKB1 by Posttranslational Modifications. B. Zheng,1,2 L. Cantley1,2; 1Harvard 1542 B689 Phosphorylation of Geminin by 1552 B699 Fyn- and Stretch-dependent Medical School, Boston, MA, 2BIDMC, Boston, MA CDK2 Regulates Its Interaction with Cdt1 and PECAM-1 Tyrosine Phosphorylation in Assembly of Pre-RC in Mitosis. F. Lu,1,2 R. Lan,1 Detergent-Extracted Endothelial Cell Model. Y. 1533 B680 Regulation of Cell Tumorigenic 1,2 1 1 1 X. Lv,1 Q. Jiang,1 Z. Zhai,1 H. Zhang,3 C. Zhang1; Chiu, E. McBeath, K. Fujiwara ; Cardiovascular Properties by Posttranslational Arginylation. R. 1College of Life Sciences, Peking University, Research Institute, University of Rochester, R. Rai,1 M. Shtutman,2 A. Kashina1; 1Animal 2 Beijing, China, 2Shihezi University School of Rochester, NY, Department of Biochemistry and Biology Department, University of Pennsylvania, Medicine, Shihezi, China, 3Yale University School Biophysics, University of Rochester, Rochester, NY Philadelphia, PA, 2Cell Biology Department, of Medicine, New Haven, CT Ordway Research Institute, Albany, NY

126 The American Society for Cell Biology 47th Annual Meeting MONDAY December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org Poster Session 2 B700–B727

1553 B700 Epidermal Growth Factor 1562 B709 Molecular Mechanism of Key 1570 B717 Tip60 Histone Acetyltransferase Signaling Requires Myosin Light Chain Kinase. Regulatory Kinase of AGC Kinase Family. K. Acts as a Negative Regulator of Notch1 A. M. Saeed,1 D. M. Helfman2,1; 1Sheila and David Yang,1,2,3 S. Shin,1 L. Piao,1 E. Shin,1 Y. Li,1 K. Signaling by Means of Acetylation. M. Kim, J. Fuente Graduate Program in Cancer Biology, Park,1 H. Byun,1 M. Won,1 Y. Kim,1 B. Choi,1 H. Mo, E. Ann, K. Lee, H. Park; SBST, Chonnam University of Miami Miller School of Medicine, Lee,1 J. Hong,1 G. Hur,1,2,4 J. Seok,1 B. A. National University, Gwangju, Republic of Korea Miami, FL, 2Department of Cell Biology and Hemmings,5 J. Park1,3,6; 1Pharmacology, College of Anatomy, University of Miami Miller School of Medicine, Chungnam National University, Daejeon, Medicine, Miami, FL Republic of Korea, 2Infection Signaling Network Extracellular Matrix and Cell Signaling I Research Center, Daejeon, Republic of Korea, 1554 B701 Blocking Heparin-induced MKP- 3Cancer Research Institute, Daejeon, Republic of 1571 B719 Rapid Signal Transduction in 1 Synthesis or Activity Interferes with Heparin- Korea, 4Daejeon Regional Cancer Center, Daejeon, the Cytoplasm Induced by Local Mechanical 1 induced Decreases in ERK Activity. R. Pugh, L. Republic of Korea, 5Freidrich Miescher Institute, Stresses. S. Na,1 O. Collin,1 F. Chowdhury,1 Y. 2 1 J. Lowe-Krentz ; Chemistry, Lehigh University, Basel, Swaziland, 6Research Institute for Medical Wang,2 N. Wang1,2; 1Department of Mechanical 2 Bethlehem, PA, Biological Sciences, Lehigh Sciences, Daejeon, Republic of Korea Science and Engineering, University of Illinois at University, Bethlehem, PA Urbana–Champaign, Urbana, IL, 2Department of 1563 B710 Arabidopsis Bioengineering, University of Illinois at 1555 B702 ERK MAP Kinase Is Targeted to Phosphatidylinositol Phosphate Kinase 1 Is a Urbana–Champaign, Urbana, IL RSK2 by the Phosphoprotein PEA-15. J. Opoku- Plant-specific Protein That Links Plasma Ansah, S. Patorino, H. Vaidyanathan, J. W. Ramos; Membrane Lipids Directly to the Actin 1572 B720 Collagen Supramolecular Natural Products and Cancer Biology, University of Cytoskeleton. Y. Im, A. J. Davis, I. Y. Perera, W. Organization and Mechanical Stiffness Elicit Hawaii at Manoa, Honolulu, HI F. Boss; Plant Biology, North Carolina State Distinct Responses from Cells. K. Bhadriraju,1 J. Elliott,2 A. Peterson,2 A. Plant2; 1SAIC Inc., 1556 B703 GDNF Signaling in University, Raleigh, NC Washington, DC, 2Cell and Tissue Measurements Spermatogonial Stem Cells via the Ras/ERK1/2 1564 B711 Role of Phospholipase D in the 1 1 1 Group, National Institute of Standards and Pathway. Z. He, J. Jiang, M. Kokkinaki, N. Endoplasmic Reticulum Stress Response. C. 1 2 1 Technology, Gaithersburg, MD Golestaneh, M. Hofmann, M. Dym ; Riebeling,1 S. Bourgoin,2 D. Shields1,3; 1 Biochemistry and Molecular & Cellular Biology, 1Developmental & Molecular Biology, Albert 1573 B721 Desmoplastic In Vivo-like 3D Georgetown University Medical Center, Einstein College of Medicine, Bronx, NY, 2Centre Matrices Induce ␣-SMA Expression and 2 Washington, DC, Veterinary Biosciences, de Recherche en Rhumatologie et Immunologie, Formation of Altered 3D-adhesions through a University of Illinois, Urbana, IL Centre de Recherche du CHUL, Ste-Foy, PQ, Src/FAK-dependent Negative Integrin Crosstalk. 3 D. A. Beacham, R. Castello-Cros, B. L. Egleston, 1557 B704 Phosphorylation of Erk1/2 Canada, Department of Anatomy and Structural M. D. Amatangelo, D. E. Zinshteyn, E. Cukierman; Following TGF-␤ Stimulation Requires Shc Biology, Albert Einstein College of Medicine, Bronx, Basic Science-Tumor Cell Biology, Fox Chase Signaling. S. M. Smith, M. K. Lee; Center for NY Cancer Center, Philadelphia, PA Craniofacial Molecular Biology, University of 1565 B712 Expression and Localization of Southern California, Los Angeles, CA R7BP, a Membrane Anchoring Protein for RGS7- 1574 B722 Biomaterial Composition and ␤ Compliance Mediated Signaling Cascades in 1558 B705 Cx43 as a Positive Regulator in G 5 Complexes, in the Central Nervous 1 D. Grabowska,1 K. Endothelial Cells. M. Shah, B. G. Kelso, M. R. TGF-␤/Smad Signaling. P. Dai, T. Nakagami, H. System. M. Jayaraman, Kaltenbronn,1 S. Sandiford,2 Q. Wang,2 S. Caplan; Arizona State University, Tempe, AZ Tanaka, T. Takamatsu; Department of Pathology Jenkins,3 V. Slepak,2 Y. Smith,3 K. Blumer1; 1Cell and Cell Regulation, Kyoto Prefectural University of Biology and Physiology, Washington University, St. 1575 B723 Form Birefringence of Collagen Medicine, Kyoto, Japan Louis, MO, 2Molecular and Cellular Pharmacology Fibers as Assessed by Image Analysis. B. d. C. Vidal; Departmento de Biologia Celular, 1559 B706 Regulation of Smad3 by GSK3- and Neuroscience Program, University of Miami Universidade Estadual de Campinas (Unicamp), mediated Phosphorylation at Its Linker Region. School of Medicine, Miami, FL, 3Yerkes National Campinas, Brazil C. A. Millet,1 M. Yamashita,1 L. Yu,2 T. Veenstra,2 Primate Research Center, Emory University, M. Heller,1 Y. Zhang1; 1Laboratory of Cellular and Atlanta, GA 1576 B724 The EIIIA/ED-A Segment of Molecular Biology, Center for Cancer Research, 1566 B713 Stimulation by Toll-like Receptor Fibronectin Regulates Fibroblast Extracellular National Cancer Institute, NCI/NIH, Bethesda, MD, Matrix Organization. A. V. Shinde, P. J. 2Laboratory of Proteomics and Analytical 5 Modulates Osteoclast Differentiation through STAT1/IFN-␤. H. Ha, J. Lee, H. Kim, H. Kwak, Z. McKeown-Longo, L. Van De Water; Center for Cell Technologies, National Cancer Institute, NCI/NIH, Biology and Cancer Research, Albany Medical Frederick, MD Lee; Cell and Developmental Biology, Seoul National University School of Dentistry, Seoul, College, Albany, NY ␦ ␤ 1560 B707 PKC Is Important to TGF 1- Republic of Korea 1577 B725 Extracellular Matrix Proteins induced Id-1 Expression in MDA-MB-231 Breast Define the Composition of Nuclear Protein Cancer Cell: Smad-independent Pathway. E. 1567 B714 Brk Oppositely Regulates RhoA and Ras and Promotes Tumorigenesis by Complexes with Alpha Actinin 4 and NF-kappaB Yun,1 K. Song,1 H. Park,2 J. Kim,1 K. Seo,1 J. 1 L. Phosphorylating p190RhoGAP. C. Shen,1 H. in Human Keratinocytes. D. Tentler, Park,1 J. Heo,1 K. Jing,1 Y. Jung,1 J. Park,1,3 G. Turoverova,1 M. Khotin,1 A. Solovyeva,1 O. Chen,1 M. Lin,1 J. Settleman,2 R. Chen3,1; 1College Kweon,1,3 S. Park,1,3 W. Yoon,1 B. Hwang,1,3 K. Petukhova,1 A. Bolshakova,1 K. Magnusson,2 G. P. of Medicine, National Taiwan University, Institute of Lim1,4; 1Department of Biochemistry, College of Pinaev1; 1Department of Cell Cultures, Institute of Molecular Medicine, Taipei, Taiwan, Medicine, Chungnam National University, Daejeon, Cytology, Russian Academy of Sciences, St. 2Massachusetts General Hospital Cancer Center Republic of Korea, 2Dr. Park’s Breast Clinic, Petersburg, Russian Federation, 2Department of Daejeon, Republic of Korea, 3Research Institute of and Harvard Medical School, Center for Molecular 3Academia Sinica, Clinical and Experimental Medicine, Linköping Medical Science, Chungnam National University, Therapeutics, Charlestown, MA, Institute of Biological Chemistry, Taipei, Taiwan University, Linköping, Sweden Daejeon, Republic of Korea, 4Cancer Research Institut, Daejeon, Republic of Korea 1568 B715 Zinc Induced Downregulation of 1578 B726 Hyaluronan Oligosaccharides Stimulate Hyaluronan Synthase-2 in 1561 B708 Dual Role of Ras for the Notch Signaling Is Associated with Cytoplasmic Retention of Notch1-IC and RBP-Jk via PI3k-Akt Chondrocytes via Activation of the Akt Regulation of Pro-apoptotic BNIP3 Expression. 1 N. Takahashi,2 W. Knudson2; Signaling Pathway. K. Lee, M. Kim, J. Mo, E. Pathway. I. Schmitz, H. An, H. Shin, X. Nam, H. Lee, S. Paik; Biology, 1Biochemistry, Rush University Medical Center, Ann, H. Park; SBST, Chonnam National University, Chungnam National University, Daejeon, Republic Chicago, IL, 2Anatomy and Cell Biology, East Gwangju, Republic of Korea of Korea Carolina University, Greenville, NC 1569 B716 Integrin-linked Kinase Controls 1579 B727 Hyaluronan-Cell Interactions Notch1 Signaling by Down-Regulation of Modulate the Cellular Response to BMP-7. C. B. Protein Stability through Fbw7 Ubiquitin Ligase. Knudson,1 R. A. Andhare,2 C. Byrd,1 W. Knudson1; J. Mo, M. Kim, S. Han, I. Kim, E. Ann, K. Lee, H. 1Anatomy and Cell Biology, East Carolina Park; SBST, Chonnam National University, University, Greenville, NC, 2Oral Biology, University Gwangju, Republic of Korea of Illinois, Chicago, IL

127 MONDAY The American Society for Cell Biology 47th Annual Meeting Poster Session 2 B728–B733 December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org

1580 B728 Effects of Echistatin, a Potent Inhibitor of Bone Resorption, on the Cytoskeleton of Cultured Osteoclasts. K. Takama, S. Kumabe, H. Mikami, Y. Iwai; Oral Anatomy, Osaka Dental University, Hirakata-shi, Japan

1581 B729 The Role of Osteopontin in Cancer Progression. B. W. Robertson, M. Chellaiah; Biomedical Sciences, University of Maryland, Baltimore, Baltimore, MD

1582 B730 Different Stromal Matrix Metalloproteinases Play Distinct Roles in Progression of Prostate Cancer. L. E. Littlepage,1 M. D. Sternlicht,1 N. Rougier,1 G. Gallo,1 Y. Yu,1 J. Gordon,2 Z. Werb1; 1Department of Anatomy, University of California, San Francisco, San Francisco, CA, 2Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St. Louis, MO

1583 B731 A Possible Role for 'Invadopodia' in MMP-9-mediated Migration in Prostate Cancer (PC3) Cells. B. Desai, M. A. Chellaiah; University of Maryland, Baltimore, Baltimore, MD

1584 B732 TGF-beta Induces Invadopodia Formation in Human Breast Cancer Cells. S. Mandal,1 M. J. Wheelock,2 K. R. Johnson2; 1Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, 2Oral Biology, University of Nebraska Medical Center, Omaha, NE

1585 B733 Tetraspanin CD151 Regulates Morphology, Motility, and Intracellular Signaling of A549 Human Lung Adenocarcinoma Cells on Laminin-10. M. Yamada, Y. Sumida, A. Fujibayashi, K. Fukaguchi, N. Sanzen, R. Nishiuchi, K. Sekiguchi; Lab. ECM Biochem., Institute for Protein Research, Osaka University, Osaka, Japan

128 The American Society for Cell Biology

Tuesday December 4, 2007

47th Annual Meeting Washington, DC TUESDAY The American Society for Cell Biology 47th Annual Meeting December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

7:00 am –8:15 pm Exhibitor Showcases

7:30 am –4:00 pm Posters on Display (Halls A/B)

7:30 am –4:00 pm Career Center (Hall B)

7:30 am–5:00 pm Registration Open (East Registration)

8:00 am –9:30 am Symposium V (Ballrooms A/B/C) Geography of Signaling

9:00 am –4:00 pm Exhibits Open (Halls A/B)

9:00 am –5:00 pm Education Resources/MAC Booth Open (Grand Lobby)

9:30 am –10:30 am Morning Refreshment Break (Halls A/B)

9:45 am–10:15 am Education Initiative Forum (Room 140A) Encouraging Students to Develop Scientifi c Thinking Skills: New Methods for Assessing Performance—Elisa Stone, Berkeley High School

10:30 am–12:00 Noon Symposium VI (Ballrooms A/B/C) Force and Form in Cell Biology

12:00 Noon–1:00 pm ASCB Business Meeting (Room 158)

12:00 Noon–3:00 pm Poster Presentations (Halls A/B) Odd Boards: 12:00 Noon–1:30 pm; Even Boards: 1:30 pm–3:00 pm

1:30 pm–3:30 pm Conversation with NIH: Scientifi c Workforce Issues: Nuts and Bolts

2:30 pm–3:30 pm Afternoon Refreshment Break (Halls A/B)

3:00 pm–3:45 pm Celldance Awards (ASCB Booth, Exhibit Hall)

3:40 pm–5:45 pm Minisymposium 17 (Room 147) Minisymposium 21 (Room 207)

Daily Schedule—Tuesday, December 4 Daily Schedule—Tuesday, Biological Oscillators Making ’omics Useful to Cell Biologists Minisymposium 18 (Ballroom A) Minisymposium 22 (Ballroom B) Cell Biology and Disease Mechanics of Cytoskeletal Systems Minisymposium 19 (Room 146) Minisymposium 23 (Ballroom C) Epithelial Morphogenesis Mitosis and Meiosis Minisymposium 20 (Room 145) Minisymposium 24 (Room 202) Evolution of Eukaryotic Endomembrane Nuclear Organization and Dynamics Systems

6:00 pm–7:00 pm CellSlam 2007 (Room 147)

7:00 pm–8:00 pm Keith R. Porter Lecture (Ballrooms A/B/C) Spatial and Topological Components of Bacterial Cell Cycle Regulatory Circuitry—Lucy Shapiro, Stanford University School of Medicine

130 The American Society for Cell Biology 47th Annual Meeting TUESDAY December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

ASCB Annual Meeting Highlights—Tuesday, December 4

Q Symposium V 8:00 am –9:30 am Ballrooms A/B/C Geography of Signaling Peter Bryant (Chair), University of California, Irvine, Howard Chang, Stanford University, Deborah Hogan, Dartmouth Medical School, Elly Tanaka, Max Planck Institute, Dresden

8:00 am Introduction 8:10 am 1586 Modulation of the Candida albicans Ras-cAMP-PKA Cascade by Microbial Molecules. D. A. Hogan, A. Davis-Hanna, A. E. Piispanen; Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, NH 8:35 am 1587 Genomic Encoding of Positional Identity. H. Y. Chang; Stanford University, Stanford, CA 9:00 am 1588 Cellular and Molecular Signalling Leading to Functional Regeneration in Vertebrates. E. M. Tanaka; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Dresden, Germany

Q Morning Refreshment Break 9:30 am–10:30 am Halls A/B Supported by Nature Publishing Group

Q Education Initiative Forum 9:45 am–10:15 am Room 140A Refreshments Served Sponsored by the Education Committee Encouraging Students to Develop Scientifi c Thinking Skills: New Methods for Assessing Performance

Elisa Stone Berkeley High School Traditional ways of assessing students often measure the science concepts students learn, but do not address the skills students must develop to explore meaningful scientifi c questions. In a research laboratory, these skills include formulating questions, using controls, analyzing data, making models, and collaborating with other scientists. Stone will discuss her assessment tools that successfully measure and promote the use of such scientifi c research skills in the classroom.

9:45 am 1589 Encouraging Students to Develop Scientifi c Thinking Skills: New Methods for Assessing Performance. E. M. Stone; Berkeley High School, Berkeley, CA

131 TUESDAY The American Society for Cell Biology 47th Annual Meeting December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

Q Symposium VI 10:30 am–12:00 Noon Ballrooms A/B/C Force and Form in Cell Biology Dennis Discher, University of Pennsylvania, Thomas Pollard (Chair), Yale University, Michael P. Sheetz, Columbia University, Valerie M. Weaver, University of California, San Francisco 10:30 am Introduction 10:40 am 1590 Stem Cell Force Generation and Differentiation. D. Discher; Molecular/Cell Biophysics Lab, University of Pennsylvania, Philadelphia, PA 11:05 am 1591 Transformation: A Force to Resist. V. M. Weaver; Department of Surgery, University of California, San Francisco, San Francisco, CA 11:30 am 1592 Shaping Cells by Force and Rigidity through Protein Stretching. M. P. Sheetz; Department of Biological Sciences, Columbia University, New York, NY

Q ASCB Business Meeting 12:00 Noon–1:00 pm Room 158 Refreshments Served All ASCB members invited to attend and cast their vote. Q Meet the ASCB Offi cers and staff. Q Learn about the ASCB’s 2007 activities. Q Hear about ASCB plans for 2008. Q Ask about how you can get involved.

Q Conversation with NIH: Scientifi c Workforce Issues: Nuts and Bolts 1:30 pm–3:00 pm Room 143 A/B

The NIH session will include a presentation on current NIH issues and policy changes followed by an opportunity to meet with NIH staff and established academic faculty in small groups to discuss graduate training and career development as well as preparing applications for fellowships, Pathway to Independence Awards, and your fi rst R01.

Q Afternoon Refreshment Break 2:30 pm–3:30 pm Halls A/B

Q Celldance 2007: The ASCB Cell Film Contest Winners 3:00 pm–3:45 pm ASCB Booth, Exhibit Hall

“Celldance 2007: The Musical!” Back by popular demand, the ASCB’s Public Information Committee-sponsored third annual cell biology fi lm contest presents the winners and screens the top entries.

132 The American Society for Cell Biology 47th Annual Meeting TUESDAY December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

Q Minisymposium 17 3:40 pm–5:45 pm Room 147

Biological Oscillators Co-Chairs: Jay C. Dunlap, Dartmouth Medical School, and Hideo Iwasaki, Waseda University 3:40 pm Introduction 3:45 pm 1593 Use of Luciferase to Analyze Core and Accessory Oscillators in a Circadian System. J. C. Dunlap,1 J. Loros,1 M. Shi,1 L. Larrondo,1 A. Mehra,1 V. Gooch,2 R. Mathur1; 1Department of Genetics, Dartmouth Medical School, Hanover, NH, 2Division of Science and Math, University of Minnesota at Morris, Morris, MN 4:00 pm 1594 The Role of the Transcription Factor Clock in the Development, Function, and Output of Circadian Pacemakers. R. Allada,1 V. Kilman,1 B. Chung,1 C. Lim,1 J. Pitman,1 S. Pradhan,1 K. Keegan,1 J. Lee,2 J. Choe2; 1Northwestern University, Evanston, IL, 2KAIST, Daejeon, Republic of Korea 4:15 pm 1595 The F-box Protein ZEITLUPE Is a Circadian Photoreceptor Stabilized by Blue-Light-enhanced Interaction with GIGANTEA. S. Fujiwara,1 W. Kim,1 S. Suh,1 L. Han,1 J. Kim,2 Y. Kim,2 K. David,3 J. Putterill,3 H. Nam,2 D. E. Somers1; 1Plant Cellular and Molecular Biology, Ohio State University, Columbus, OH, 2Department of Life Science, Pohang University of Science and Technology, Pohang, Republic of Korea, 3School of Biological Sciences, University of Auckland, Auckland, New Zealand 4:30 pm 1596 Mechanism of the Neurospora Circadian Negative Feedback Loop. Y. Liu, Q. He, G. Huang, J. Cha; Physiology, University of Texas Southwestern Medical Center, Dallas, TX 4:45 pm 1597 Spatio-Temporal Pattern Formation in Cyanobacteria: From Rhythms to Morphogenesis. H. Iwasaki; Department of Electrical Engineering and Bioscience, Waseda University, Tokyo, Japan 5:00 pm 1598 Decoding the Transcriptional Pleiotropy of Coactivators and Repressors. J. E. Baggs,1 A. L. Amelio,2 L. Miraglia,3 R. Mercer,2 J. Conkright,2 M. Conkright,2 J. Hogenesch1; 1Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA, 2Cancer Biology, The Scripps Research Institute, Jupiter, FL, 3Cell Based Screening, The Genomics Institute of the Novartis Research Foundation, La Jolla, CA 5:15 pm 1599 Deregulation of the Circadian Clock and Tumorigenesis. M. Antoch,1 E. Vykhovanets,2 V. Gorbacheva,2 I. Toshkov,3 R. Kondratov,2 C. Lee,4 A. Nikitin3; 1Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, NY, 2Cancer Biology, Cleveland Clinic Foundation, Cleveland, OH, 3Cornell University, Ithaca, NY, 4Florida State University, Tallahassee, FL 5:30 pm 1600 Glycogen Synthase Kinase-β Exploits Intracellular Noise to Regulate Xenopus Oocyte Maturation. Q. A. Justman,1 H. El-Samad,2 K. M. Shokat3; 1Graduate Group in Biophysics, University of California, San Francisco, San Francisco, CA, 2Biochemistry, University of California, San Francisco,, San Francisco, CA, 3Cellular & Molecular Pharmacology, University of California, San Francisco/HHMI, San Francisco, CA

Q Minisymposium 18 3:40 pm–5:45 pm Ballroom A Supported by Merck Research Laboratories Cell Biology and Disease Co-Chairs: Lucy A. Godley, The University of Chicago, and Timothy J. Mitchison, Harvard Medical School 3:40 pm Introduction 3:45 pm 1601 Primary Role for Centrosome Proteins in Cilia Formation and Cilia-associated Disorders. B. Delaval, L. Covassin- Barberis, N. Lawson, S. J. Doxsey; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 4:00 pm 1602 Inversin Links Nodal Flow, Calcium Signaling, and Cell Behavior in the Development of LR Asymmetry. S. Makova,1 Z. Sun,2 J. McGrath,3 M. Brueckner1; 1Pediatrics/Cardiology, Yale University School of Medicine, New Haven, CT, 2Genetics, Yale University School of Medicine, New Haven, CT, 3Comparative Medicine, Genetics and Pediatrics, Yale University School of Medicine, New Haven, CT 4:15 pm 1603 A Truncated DNMT3B Protein Expressed in Cancer Cells Disrupts Embryonic Development in Transgenic Mice. M. Y. Shah,1 C. Hendrick,1 M. E. Figueroa,2 N. Y. Barnes,1 A. Kamp,3 S. E. Volker,1 K. R. Ostler,1 G. Patel,1 E. W. Larson,1 I. Moskowitz,3 A. Melnick,4 P. Pytel,5 L. A. Godley1; 1Department of Medicine, The University of Chicago, Chicago, IL, 2Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY, 3Department of Pediatrics, The University of Chicago, Chicago, IL, 4Departments of Medicine and Developmental and Molecular Biology, Albert Einstein College of Medicine, Chicago, IL, 5Department of Pathology, The University of Chicago, Chicago, IL 133 TUESDAY The American Society for Cell Biology 47th Annual Meeting December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

4:30 pm 1604 High Rates of Aneuploidy Cause Cell Death and Tumor Suppression. B. A. A. Weaver, A. D. Silk, D. W. Cleveland; Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA 4:45 pm 1605 Binding of the HBV X Protein to hBubR1 Disturbs the Mitotic Checkpoint and Increases . S. Kim,1 S. Park,1 F. Jakub,2 S. Chae,1 J. Lee,1 C. Kang,3 H. Saya,4 G. Chan,2 H. Cho1; 1Biochemistry & Molecular Biology, Ajou University School of Medicine, Suwon, Republic of Korea, 2Oncology, University of Alberta, Edmonton, AB, Canada, 3Korea Institute for Radiological and Medical Sciences, Seoul, Republic of Korea, 4Tumor Genetics, Kumamoto University, Kumamoto, Japan 5:00 pm 1606 Cell-Type Variation in Responses to Anti-mitotic Drugs. T. J. Mitchison, C. Loy, J. Orth, C. Shamu, J. Shi, M. Tsui, T. Xie, V. Yanamadala; Systems Biology, Harvard Medical School, Boston, MA 5:15 pm 1607 Huntingtin Regulates Microtubule-based Transport of Vesicles: New Approaches to Restore Axonal Transport. F. Saudou, E. Colin, D. Zala, S. Humbert; Institut CURIE - UMR146 CNRS, Orsay, France 5:30 pm 1608 Myosin 1e and Renal Filtration: A Novel Function for a Type I Myosin. M. Krendel,1 T. Willinger,2 S. V. Kim,3 R. A. Flavell,2 M. S. Mooseker4; 1Cell and Developmental Biology, SUNY Upstate Medical University, Syracuse, NY, 2Section of Immunobiology, Yale University, New Haven, CT, 3Molecular Pathogenesis, New York University School of Medicine, New York, NY, 4Molecular, Cellular, and Devleopmental Biology, Yale University, New Haven, CT

Q Minisymposium 19 3:40 pm–5:45 pm Room 146

Epithelial Morphogenesis Co-Chairs: M. Thomas Lecuit, Developmental Biology Institute of Marseilles-Luminy, and Jennifer Zallen, Sloan-Kettering Institute 3:40 pm Introduction 3:45 pm 1609 Polarized Cell Behavior during Axis Elongation in Drosophila. J. A. Zallen, J. Blankenship, J. S. P. Sanny, O. Weitz; Developmental Biology Program, Sloan-Kettering Institute, New York, NY 4:00 pm 1610 Anisotropic Intercellular Surface Tension Is Suffi cient to Rearrange Cell Patterns and Drive Intercalation in Epithelia. P. Vérant,1,2 T. Lecuit,2 P. F. Lenne1; 1Institut Fresnel–CNRS & University of Marseille, Marseille, France, 2IBDML –CNRS & University of Marseille, Marseille, France 4:15 pm 1611 Coupling Cell Cycle Morphogenesis and Mitotic Spindle Orientation to Regulate Tissue Morphogenesis. S. Courty,1 J. Friedlander,2 F. Graner,3 Y. Bellaiche4; 1LKB, Ecole Normale Supérieure, PARIS, France, 2UMR144, Institut Curie, PARIS, France, 3Laboratoire de Spectrométrie Physique, CNRS–Université Grenoble I, Grenoble, France, 4Institut Curie, PARIS, France 4:30 pm 1612 The Infl uence of Mechanics, Adhesion, and Mitosis on Epithelial Cell Packing. J. Roeper,1 R. Farhadi-Far,2 F. Julicher,2 S. Eaton1; 1Max-Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany, 2Max-Planck Institute for Physics of Complex Systems, Dresden, Germany 4:45 pm 1613 Microtubule Reorientation Dictates the Direction of Apoptotic Cell Extrusion from an Epithelial Monolayer. G. Slattum,1 K. McGee,2 L. Cramer,3 J. Rosenblatt1; 1Oncological Sciences, Huntsman Cancer Institute, Salt Lake City, UT, 2University College London, Institute of Ophthalmalogy, London, United Kingdom, 3University College London, MRC–Laboratory for Molecular Cell Biology, London, United Kingdom 5:00 pm 1614 Cdc42 Modulates Exocytosis of Apical Proteins to Form the Lumen during Epithelial Morphogenesis. F. Martin- Belmonte,1 K. Mostov2; 1Centro de Biologia Molecular Severo Ochoa, Cantoblanco, Spain, 2Anatomy, University of California, San Francisco, San Francisco, CA 5:15 pm 1615 Active Apicobasal Shortening Constrained by Circumapical Collars Drives Endoderm Invagination in Ascidians. K. M. Sherrard,1 F. B. Robin,2 E. M. Munro,1 P. Lemaire2; 1Center for Cell Dynamics, University of Washington, Friday Harbor, WA, 2Institute for Developmental Biology of Marseille-Luminy, Marseilles, France 5:30 pm 1616 Mammary Epithelial Morphogenesis Results from the Coordinate and Opposing Motility of Luminal and Myoepithelial Cells. A. J. Ewald, B. S. Chan, M. Duong, Z. Werb; Anatomy, University of California, San Francisco, San Francisco, CA

134 The American Society for Cell Biology 47th Annual Meeting TUESDAY December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

Q Minisymposium 20 3:40 pm–5:45 pm Room 145

Evolution of Eukaryotic Endomembrane Systems Co-Chairs: John A. Fuerst, University of Queensland, and Trevor Lithgow, University of Melbourne 3:40 pm Introduction 3:45 pm 1617 Endomembrane Systems and Cell Division in Planctomycete Bacteria. K. Lee, J. Fuerst; School of Molecular and Microbial Sciences, University of Queensland, Brisbane, Australia 4:00 pm 1618 Identifi cation of a Key Component of the Eukaryotic Endomembrane System in Compartmentalized Bacteria. D. P. Devos; European Molecular Biology Laboratory, Heidelberg, Germany 4:15 pm 1619 Phylogenetic Analyses of Membrane-Traffi cking Protein Families Suggest a Sophisticated Endomembrane System in the Last Common Eukaryotic Ancestor. J. B. Dacks; Pathology, University of Cambridge, Cambridge, United Kingdom 4:30 pm 1620 An Elaborate Classifi cation of SNARE Proteins Sheds Light on the Conservation of the Eukaryotic Endomembrane System. K. Tobias,1 N. Kienle,2 D. Fasshauer2; 1Center for Bioinformatics, University of Tuebingen, Tuebingen, Germany, 2Structural Biochemistry, MPI for Biophysical Chemistry, Goettingen, Germany 4:45 pm 1621 Origin of Vesicle Coat Systems. W. E. Balch, A. Koulov, P. LaPointe, B. Tanasa, S. Stagg; Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 5:00 pm 1622 Organization of the Early Secretory Pathway in the Malaria Parasite Plasmodium falciparum. M. Lee, P. Moura, D. Fidock; Microbiology, Columbia University, New York, NY 5:15 pm 1623 Evolution of Membrane Transport Systems: Insights from Parasitic Protists. M. C. Field; Pathology, University of Cambridge, Cambridge, United Kingdom 5:30 pm 1624 Evolution of Molecular Machines to Drive Protein Import into Mitochondria. T. Lithgow,1 D. Bursa,1 M. Dagley,1 P. Dolezal,1 J. Tachezy,2 A. Schneider,3 V. A. Liki 4; 1Biochemistry & Molecular Biology, University of Melbourne, Parkville, Australia, 2Charles University, Prague, Czech Republic, 3University of Fribourg, Fribourg, Switzerland, 4Bio21 Institute, University of Melbourne, Parkville, Australia

Q Minisymposium 21 3:40 pm–5:45 pm Room 207

Making ’omics Useful to Cell Biologists Co-Chairs: John D. Aitchison, Institute for Systems Biology, and Nevan J. Krogan, University of California, San Francisco 3:40 pm Introduction 3:45 pm 1625 Systems Approaches to Understanding Peroxisome Biogenesis. R. A. Saleem, J. J. Smith, B. Knoblach, F. Mast, A. Fagarasanu, M. Marelli, S. Ramsey, Y. Wan, A. Niemisto, J. Boyle, I. Shmulevich, R. A. Rachubinski, J. D. Aitchison; Institute of Systems Biology, Seattle, WA 4:00 pm 1626 Determining the Molecular Architectures of Cellular Machines by Satisfaction of Spatial Restraints: The Nuclear Pore Complex. F. Alber,1 S. Dokudovskaya,2 L. M. Veenhoff,3 D. Devos,4 B. T. Chait,5 M. P. Rout,6 A. Sali1; 1Department of Biopharmaceutical Sciences, University of California, San Francisco, San Francisco, CA, 2Institut Jacques Monod, Paris, France, 3Department of Biochemistry, University of Groningen, Groningen, Netherlands Antilles, 4European Molecular Biology Laboratory, Heidelberg, Germany, 5Laboratory of Mass Spectrometry and Gaseous Ion Chemistry, The Rockefeller University, New York, NY, 6Laboratory of Cellular and Structural Biology, The Rockefeller University, New York, NY 4:15 pm 1627 Organellar Proteomics to Create the Cell Map. C. E. Au,1 A. W. Bell,1 R. E. Kearney,1 M. Hallett,1 L. Hermo,1 T. Nilsson,2 J. J. M. Bergeron1; 1McGill University, Montreal, PQ, Canada, 2Göteborg University, Göteborg, Sweden 4:30 pm 1628 Proteomic Analysis of Basolaterally-targeted Vesicles Using Fluorescence-activated Vesicle Sorting by LC-MS/MS. Z. Cao,1 C. Li,1 J. N. Higginbotham,1 R. J. Coffey2,3; 1Department of Medicine, Vanderbilt University, Nashville, TN, 2Departments of Medicine and Cell and Developmental Biology, Vanderbilt University, Nashville, TN, 3Veterans Affairs Medical Center, Nashville, TN 4:45 pm 1629 A Conserved Network of Human MAPK Interactions. S. Bandyopadhyay,1 M. Gersten,1 R. Bell,2 S. Sahasrabudhe,2 T. Ideker1; 1Bioenginnering and Bioinformatics, University of California, San Diego, La Jolla, CA, 2Prolexys Pharmaceuticals, Salt Lake City, UT 5:00 pm 1630 Genome-wide High-Resolution Mapping Reveals a Global Effect of the Exosome Complex on Heterochromatic Transcripts and Uncovers a Hidden Layer in the Arabidopsis Transcriptome. J. Chekanova,1 B. Gregory,2 S. Reverdatto,3 135 TUESDAY The American Society for Cell Biology 47th Annual Meeting December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

H. Chen,4 J. Yazaki,2 R. Kumar,1 T. Hooker,1 Q. Peng,2 J. Ecker,2 D. Belostotsky1; 1University of Missouri–Kansas City, Kansas City, MO, 2Plant Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, 3University at Albany, SUNY-Albany, NY, 4Genomic Analysis Laboratory, Salk Institute for Biological Studies, La Jolla, CA 5:15 pm 1631 Transcriptome and Interaction Analyses of the Giardia lamblia Basal Body Proteome. T. Lauwaet,1 D. Reiner,1 E. P. Romijn,2 M. Baitaluk,3 D. Palm,4 B. Davids,1 S. Svard,4 A. G. McArthur,5 A. Ray,3 A. Gupta,3 J. Yates,2 F. D. Gillin1; 1Department of Pathology, Division of Infectious Diseases, University of California, San Diego, San Diego, CA, 2The Scripps Research Institute, La Jolla, CA, 3San Diego Supercomputer Center, San Diego, CA, 4Uppsala University, Uppsala, Sweden, 5Andrew McArthur Consulting, Hamilton, ON, Canada 5:30 pm 1632 An E-MAP of Kinase and Phosphatase Signaling in Saccharomyces cerevisiae. D. Fiedler, S. R. Collins, Y. Nijati, E. Cheng, N. J. Krogan, K. M. Shokat; Howard Hughes Medical Institute and Department of Molecular and Cellular Pharmacology, University of California, San Francisco, San Francisco, CA

Q Minisymposium 22 3:40 pm–5:45 pm Ballroom B

Mechanics of Cytoskeletal Systems Co-Chairs: Margaret L. Gardel, The University of Chicago, and Wolfgang Losert, University of Maryland, College Park 3:40 pm Introduction 3:45 pm 1633 Actin Dynamics Regulate a Biophysical Maturation Switch in Focal Adhesions. M. L. Gardel,1 B. Sabass,2 L. Ji,3 G. Danuser,3 U. Schwarz,2 C. M. Waterman4; 1The James Franck Institute, The University of Chicago, Chicago, IL, 2BIOQUANT, Heidelberg University, Heidelberg, Germany, 3Cell Biology, The Scripps Research Institute, La Jolla, CA, 4National Heart, Lung & Blood Institute/NIH, Bethesda, MD 4:00 pm 1634 Capping Protein Controls the Rate of Actin Filament Nucleation by the Arp2/3 Complex. O. Akin, R. D. Mullins; Cellular & Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 4:15 pm 1635 Mitosis-specifi c Mechanosensing and Contractile-Protein Redistribution Control Cell Shape. J. C. Effl er,1 Y. Ren,2 E. Reichl,2 Y. Kee, 3 M. Tran,4 P. A. Iglesias,1 D. N. Robinson2; 1Electrical Engineering, Johns Hopkins University, Baltimore, MD, 2Cell Biology, Johns Hopkins University, Baltimore, MD, 3Institute for Multiscale Modeling of Biological Interactions Johns Hopkins University, Baltimore, MD, 4Johns Hopkins University, Baltimore, MD 4:30 pm 1636 Nonequilibrium Mechanics of Active Cytoskeletal Networks from In Vitro Model System to Cultured Living Cells. D. Mizuno,1 C. Tardin,2 R. Bacabac,3 D. Head,4 F. MacKintosh,5 C. Schmidt6; 1Organization for the Promotion of Advanced Research, Kyushu University, Fukuoka, Japan, 2IPBS-CNRS, Toulouse, France, 3Acta-Vrije University, Amsterdam, The Netherlands, 4University of Tokyo, Tokyo, Japan, 5Vrije University, Amsterdam, The Netherlands, 6Georg-August-University Goettingen, Goettingen, Germany 4:45 pm 1637 Shear Stress Alters the Mechanical Properties and Organization of Intermediate Filament Networks. K. M. Ridge,1 F. Flitney,2 S. Sivaramakrishnan,3 R. D. Goldman2; 1Pulmonary and Critical Care, Northwestern University, Chicago, IL, 2Cell and Molecular Biology, Northwestern University, Chicago, IL, 3Biochemistry, Stanford University, Stanford, CA 5:00 pm 1638 Bipedal Locomotion in Crawling Cells. E. L. Barnhart,1 G. M. Allen,1 F. Julicher,2 J. A. Theriot1; 1Stanford University, Stanford, CA, 2Max-Planck-Institut fur Physik komplexer Systeme, Dresden, Germany 5:15 pm 1639 Anterograde Microtubule Transport Drives Microtubule Bending in LLC-PK1 Epithelial Cells. A. D. Bicek,1 E. Tüzel,2 M. Uppalapati,3 W. O. Hancock,3 D. M. Kroll,2 D. J. Odde1; 1Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN, 2Department of Physics, North Dakota State University, Fargo, ND, 3Department of Bioengineering, Penn State University, University Park, PA 5:30 pm 1640 Direct Visualization of Deformations and Relaxations of In Vitro Actin Networks. E. C. Rericha,1 D. Sisan,2 A. Pomerance,1 R. McAllister,2 J. Urbach,2 W. Losert1; 1Institute for Research in Electronics and Applied Physics, University of Maryland, College Park, MD, 2Physics, Georgetown University, Washington, DC

136 The American Society for Cell Biology 47th Annual Meeting TUESDAY December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

Q Minisymposium 23 3:40 pm–5:45 pm Ballroom C

Mitosis and Meiosis Co-Chairs: Sue Biggins, Fred Hutchinson Cancer Research Center, and Dean Dawson, Oklahoma Medical Research Foundation 3:40 pm Introduction 3:45 pm 1641 Cytoskeletal Forces Span the Nuclear Envelope to Mediate Chromosome Dynamics during Meiosis. A. Sato,1,2 C. M. Phillips,3 B. Isaac,4 R. A. Kasad,3 *A. F. Dernburg3,1; 1Life Sciences Division, Lawrence Berkeley National Lab, Berkeley, CA, 2Graduate School of Biostudies, Kyoto University, Kyoto, Japan, 3Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, 4Organic Chemistry, Weizmann Institute of Science, Rehovot, Israel 4:00 pm 1642 Telomeres Mediate Rapid, Autonomous Movements Regulated by Chromosome Status during Meiotic Prophase. C. Lee,1,2 M. Conrad,1 J. Conchello,1,3 G. Chao,1 M. Shinohara,4 H. Kosaka,4 A. Shinohara,4 M. Dresser1,2; 1Molecular, Cell and Developmental Biology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 2Cell Biology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, 3Engineering, Oklahoma University, Norman, OK, 4Division of Integrated Protein Functions, Institute for Protein Research, Osaka University, Osaka, Japan 4:15 pm 1643 Aurora A Kinase Regulates Kif2 Activity at Centrosomes to Focus Microtubules Toward Chromatin. A. L. Knowlton, P. T. Stukenberg; Biochemistry, University of Virginia, Charlottesville, VA 4:30 pm 1644 Rings Are Not Required for Processive Microtubule Driven Movement of the Dam1 Complex. D. R. Gestaut,1 B. Graczyk,1 J. Cooper,2 A. Zelter,1 P. Widlund,1 L. Wordeman,2 C. L. Asbury,2 T. N. Davis 1; 1Biochemistry, University of Washington, Seattle, WA, 2Physiology and Biophysics, University of Washington, Seattle, WA 4:45 pm 1645 Biomechanical Design of Molecular Couplers That Transduce Microtubule Depolymerization into Chromosome Movement. E. L. Grishchuk,1,2 A. Efremov,1,3 I. S. Spiridonov,1,3 V. A. Volkov,1,3 S. Westermann,4 I. M. Cheeseman,5 A. Desai,5 D. Drubin,6 G. Barnes,6 F. I. Ataullakhanov,3,7,8 J. R. McIntosh1; 1Molecular, Cellular, and Developmental Biology, University of Colorado at Boulder, Boulder, CO, 2Institute of General Pathology and Pathophysiology, Moscow, Russian Federation, 3National Research Center for Haematology, Moscow, Russian Federation, 4Research Institute of Molecular Pathology, Vienna, Austria, 5Ludwig Institute for Cancer Research, Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, 6Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, 7Physics Department, Moscow State University, Moscow, Russian Federation, 8Center for Theoretical Problems of Physicochemical Pharmacology, RAS, Moscow, Russian Federation 5:00 pm 1646 Real-Time Imaging of a Kinetochore Biosensor Reveals Novel Aspects of Tension Generation during Mitosis. T. J. Maresca,1,2 J. C. Gatlin,1,2 A. C. Groen,3,2 E. D. Salmon1,2; 1Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 2Marine Biological Laboratory, Woods Hole, MA, 3Systems Biology, Harvard Medical School, Boston, MA 5:15 pm 1647 Spatial and Temporal Phosphorylation Patterns in Anaphase. M. A. Lampson,1 E. A. Foley,2 T. M. Kapoor2; 1Biology, University of Pennsylvania, Philadelphia, PA, 2Laboratory of Chemistry and Cell Biology, The Rockefeller University, New York, NY 5:30 pm 1648 Examining the Link between Chromosomal Instability and Aneuploidy in Human Cells. S. L. Thompson, D. A. Compton; Biochemistry, Dartmouth Medical School, Hanover, NH *Early Career Life Scientist Awardee

137 TUESDAY The American Society for Cell Biology 47th Annual Meeting December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

Q Minisymposium 24 3:40 pm–5:45 pm Room 202

Nuclear Organization and Dynamics Co-Chairs: Sui Huang, Northwestern University Feinberg School of Medicine, and Susan R. Wente, Vanderbilt University Medical Center 3:40 pm Introduction 3:45 pm 1649 The Association of the PNC with the Malignant Phenotype. J. Norton, S. Huang; Department of Cell and Molecular Biology, Northwestern University Feinberg School of Medicine, Chicago, IL 4:00 pm 1650 U snRNPs in Drosophila: Cajal Bodies and Histone Locus Bodies in the Nucleus, U Bodies in the Cytoplasm. J. Liu, J. G. Gall; Embryology, Carnegie Institution, Baltimore, MD 4:15 pm 1651 Prelamin-A Accumulation in Hutchison-Gilford Progeria Syndrome and Human Cell Ageing Deregulates Nuclear ERK Signaling and Induces Cell Death by Disrupting Nesprin-2/PML Interactions. D. T. Warren, T. Tajsic, Q. Zhang, C. Ragnauth, C. M. Shanahan; Division of Cardiovascular Medicine, University of Cambridge, Cambridge, United Kingdom 4:30 pm 1652 DNA Damage Is Not Required for the Action of DNA Damage Response Pathways. E. Soutoglou, T. Misteli; Cell Biology of Gene Expression, National Cancer Institute/NIH, Bethesda, MD 4:45 pm 1653 Live Images of RNA Polymerase II Transcriptional Units in Amphibian Oocytes. S. B. Patel,1 B. Beenders,2 C. Austin,2 N. Novikova,2 M. Bellini2; 1Biochemistry and College of Medicine, University of Illinois at Urbana–Champaign, Urbana, IL, 2Cell & Developmental Biology, University of Illinois at Urbana–Champaign, Urbana, IL 5:00 pm 1654 Novel Chromatin-associated Proteins Are Required for Programmed Genome Rearrangements in Tetrahymena. D. L. Chalker, C. H. Rexer; Biology, Washington University in St. Louis, St. Louis, MO 5:15 pm 1655 Connections between the Nuclear Envelope and Microtubules Are Anchored by a Network of Integral Membrane Proteins and Heterochromatin. M. C. King, G. Blobel; Cell Biology, The Rockefeller University, New York, NY 5:30 pm 1656 Negative Regulation of Formins by WISH/DIP1: Actin Filaments in the Nucleus. R. Basu, F. Chang; Microbiology, Columbia University, New York, NY

Q Finals of CellSlam 2007: The DC Throwdown 6:00 pm–7:00 pm Room 147 “CellSlam 2007: The DC Throwdown” is the ASCB Public Information Committee’s second stab at a stand-up science slam. Finalists get a microphone, the fl oor, no AV, and exactly three minutes to put over a science issue, concept, and/or discovery to a live audience and a judging panel that will include NIH Director Elias Zerhouni, and science reporters from The New York Times, The Washington Post, and Science Magazine.

Q Keith R. Porter Lecture 7:00 pm–8:00 pm Ballrooms A/B/C Spatial and Topological Components of Bacterial Cell Cycle Regulatory Circuitry

Lucy Shapiro Stanford University School of Medicine

7:00 pm 1657 Dynamic Cell Architecture: An Integral Component of Bacterial Cell Cycle Control. L. Shapiro; Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA

138 The American Society for Cell Biology 47th Annual Meeting TUESDAY December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

EXHIBITOR SHOWCASES WASHINGTON CONVENTION CENTER

Amaxa GmbH 7:00 am–9:00 am, Room 201 Pierce 9:15 am–11:15 am, Room 201 RNAi and Cell-based Assays in Diffi cult-to-Transfect Cell Lines and Thermo Scientifi c Cellomics Reagent Solutions for High Content Primary Cells - Amaxa AG in collaboration with Promega Corp. Screening Level: Advanced Level: Introductory Presenter: Andrea Toell Presenter: Richik N. Ghosh Amaxa AG Promega Corp. Thermo Fisher Scientifi c Nattermannallee 1 2800 Woods Hollow Road Pierce Products Cologne, 50829 Germany Madison, WI 53711 PO Box 117 Phone: (011) 49-22199-1990 Phone: (608) 274-4330 Rockford, IL 61105 Fax: (011) 49-173548-4515 www.promega.com Phone: (815) 968-0747 www.amaxa.com Fax: (815) 968-7316 www.thermo.com/cellomics RNAi-based screening is an emerging tool for discovery of potential therapeutic targets in many disease areas. Reliability of results depends To utilize the full potential of the powerful multiparametric capabili- on using a cell type relevant to the disease of interest and not only on ties of HCS, an innovative range of reagents must be utilized. Under- using high quality siRNA or shRNA substrates. These cells are often standing cellular processes and fl uorescent technologies is vital to the diffi cult to transfect with standard methods. For such cells Amaxa’s process of using HSC to its full potential. We provide an integrated Nucleofector® Technology is the method of choice, achieving highly set of products that work together to deliver a “total solution” platform effi cient substrate delivery in any type of cell, including primary cells. In for HCS. Integral components of this set are the Cellomics HCS addition, choosing a meaningful and robust phenotypic assay is crucial Reagent Kits. These kits provide easy-to-use methods and reagents to account for the unknown complexity of the phenotypic response. for preparing high-quality samples for automated cell-based imaging Promega’s high quality cell-based assays—ranging from more general assays. This presentation will feature a new line of innovation Cel- assays for e.g., viability, apoptosis, or metabolism to more specifi c ones lomics HCS Kits. for e.g., GPCRs—measure a broad variety of phenotypic responses. Platypus Technologies 9:15 am–11:15 am, Room 206 Corning Incorporated 7:00 am–9:00 am, Room 206 Recent Developments in Cell Migration Solving Cell Culture Problems Level: Intermediate/Advanced Level: Intermediate Presenters: Joan Brugge, Gabe Fenteany, Alan Howe, and Presenter: John A. Ryan Patricia Keely Corning Incorporated Platypus Technologies 900 Chelmsford Street Tower 2, 4th Floor 5520 Nobel Drive, Suite 100 Lowell, MA 01851 Madison, WI 53711 Phone: (978) 442-2200 Phone: (866) 296-4455 Fax: (978) 442-2476 Fax: (608) 237-1271 www.corning.com/lifesciences www.platypustech.com

Problems and cell culture seem to go together, perhaps because cell Cell migration is essential for normal development, angiogenesis, culture is a living tool. This seminar will discuss problem-solving tools maintenance of homeostasis, wound healing, the metastasis of cancer, and strategies for identifying and correcting some of the common and and many other bodily processes. Platypus Technologies is pleased to not so common cell culture problems. If not effectively dealt with, these present this Showcase featuring experts in cell migration research as problems can result in culture loss and erroneous data, disrupt research, they focus on current developments and related issues in the fi eld. and lead to personal embarrassment. Approaches for managing these Researchers both in academia and in the pharmaceutical industry who problems will be discussed, with special attention given to problems are interested in detecting the movement of cells more quickly and in with culture media—especially pH and toxicity from fl uorescent lights; a reproducible manner using cell-based assays should plan to attend. vessels—especially cell attachment and “spotty” growth; and incuba- tors—especially vibration and temperature issues.

139 TUESDAY The American Society for Cell Biology 47th Annual Meeting December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

EXHIBITOR SHOWCASES WASHINGTON CONVENTION CENTER BD Biosciences 11:30 am–12:30 pm, Room 206 as a protein immobilization tag depending on which ligand is bound The Importance of Surface Modifi cations/Coatings for Improving to it. We will present several applications demonstrating advantages of Cell Culture HaloTag® technology including multicolor labeling of proteins and Level: Introductory temporal/spatial separation of protein pools. We will also describe the Presenter: Kevin Chen use of HaloTag® for isolation of intracellular protein:DNA complexes BD Biosciences as an alternative to traditional ChIP assay. Two Oak Park Drive Bedford, MA 01730 BD Biosciences 12:30 pm–1:30 pm, Room 206 Phone: (877) 232-8995 Screening and Development of Antibodies for Use in Fax: (301) 340-9775 Immunofl uorescent Microscopy www.bdbiosciences.com Level: Introductory Presenter: Mindy D. Goldsborough It is well known that surface modifi cations and/or coatings can affect BD Biosciences cell culture signifi cantly. But the relationship between cell types and their 15010 Broschart Road “preferred” surface properties are still not understood. Directly transfer- Rockville, MD 20850 ring the knowledge of the preferred surface obtained for one cell type Phone: (301) 340-7320 x21 to another cell type can be misleading. Adding to the complexity, the Fax: (301) 340-9775 preferred surface of one cell type may change from one media condi- www.bdbiosciences.com tion to another. This Showcase will illustrate this complexity through a collection of data comparing different surfaces for different cell culture Cellular imaging utilizes a variety of fl uorescent dyes and protein- applications. First, the physical properties, including contact angle and specifi c reagents such as antibodies or fl uorescent proteins. However, ESCA analysis, of the unmodifi ed and modifi ed/coated surfaces com- many of the antibodies currently available have not been specifi cally monly used in cell culture will be reviewed. Then, results of several cell tested for use in imaging applications. To facilitate the use of antibod- culture applications on these surfaces will be compared. The cell culture ies for imaging applications, BD Biosciences embarked on a screening applications studied include the culture of several commonly used cell process to evaluate a large library of monoclonal antibodies for utility types in media with serum or in serum-free media, neuronal cell growth in bioimaging applications. The library of antibodies included speci- and neurite outgrowth, attachment of cryopreserved hepatocytes, and fi cities that recognized proteins involved in cell signaling, cell cycle, maintaining human embryonic stem cells in undifferentiated states. To apoptosis, cancer, stem cells, and neurobiology. Antibodies were tested compare the effect of surfaces, cell culture applications were performed using appropriate cell lines and several fi x/perm methods. Specifi c on different surfaces under the same conditions, and the results are criteria regarding signal to noise, subcellular localization, and other compared by analysis of cell morphology, quantifi cation of cell numbers, important parameters were used to qualify reagents. Two distinct BD measurement of neurite outgrowth and other analysis of cell properties. Bioimaging Certifi ed reagent product lines resulted from this antibody The results provide a useful guide for selecting and searching for better screen. One is a continually expanding collection of greater than 250 surfaces for different cell culture applications. unlabeled primary antibodies that have been shown to have general utility in bioimaging applications. The other is a subset of these re- Promega Corporation 11:30 am–1:30 pm, Room 201 agents that have been further developed into primary conjugated HaloTag®: Integrating Imaging and Protein Analysis antibodies to facilitate multiplexed assays where several cellular signals Level: Intermediate are simultaneously measured and analyzed. These reagents enable the Presenters: Marjeta Urh and Georgyi Los rapid development of novel cell-based assays. Promega Corporation 2800 Woods Hollow Road Applied Biophysics, Inc. 1:45 pm–3:45 pm, Room 201 Madison, WI 53711 ECIS: A Morphological Biosensor for Cell Research Phone: (608) 274-4330 Level: Introductory Fax: (608) 277-2601 Presenter: Charles Keese www.promega.com Applied BioPhysics 185 Jordan Road We will describe a new technology that integrates multiple capa- Troy, NY 12180 bilities, including specifi c protein labeling, imaging, and protein im- Phone: (518) 880-6860 mobilization. The technology is based on a new protein fusion tag, Fax: (518) 880-6865 the HaloTag® and a series of synthetic ligands that specifi cally and www.biophysics.com covalently bind the HaloTag® protein. The ligands carry a variety of functionalities, such as fl uorescent labels, affi nity handles, and solid In Electric Cell-substrate Impedance Sensing (ECIS), cells are grown supports. Thus, HaloTag® can serve either as a protein labeling tag or upon small gold electrodes carrying weak AC signals. Changes in cell

140 The American Society for Cell Biology 47th Annual Meeting TUESDAY December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

EXHIBITOR SHOWCASES WASHINGTON CONVENTION CENTER morphology result in impedance changes that can be monitored in real In the workshop learn how Extracellular Flux (XF) assays allow you time to quantify cell behavior in a continuous fashion. Data from the to quantify physiological changes in cellular bioenergetics by measuring biosensor will be displayed showing measurements of cell attachment the two major energy yielding pathways, mitochondrial respiration and spreading, motility, and the barrier function of cell monolayers. and glycolysis. Learn about the XF advantages for measuring real-time Applications to be discussed include measurements of metastatic metabolism; how the bioenergetic state of a cell defi nes its physiology potential, signal transduction, cytopathic effects of viral infections, or pathophysiology; and how to perform XF assays to measure ATP and cell-ECM interactions. New modifi cations in hardware permit turnover, substrate utilization, and mitochondrial function. determination of cell migration via an automated wound healing assay and appraisal of cells under fl ow conditions. The ECIS system is now Corning Incorporated 4:00 pm–6:00 pm, Room 206 available in a 96-well format for HTS needs. Promoting Tissue Performance—Evolution of Permissive Culture Surface Chemistries and Topographies Seahorse Bioscience, Inc. 1:45 pm–2:30 pm, Room 206 Level: Intermediate Advances in Measuring Cellular Bioenergetics Presenter: Michael W. Briggs Level: Intermediate Corning Incorporated Presenter: David Ferrick 900 Chelmsford Street Tower 2, 4th Floor Seahorse Bioscience, Inc. Lowell, MA 01851 16 Esquire Road Phone: (978) 442-2200 North Billerica, MA 01862 Fax: (978) 442-2476 Phone: (978)-671-1600 www.corning.com/lifesciences Fax: (978)-671-1611 www.seahorsebio.com A century ago, Ross Harrison’s in vitro growth of nerve fi bers launched tissue culture (TC) as one of the most important techniques in life Extracellular Flux enables non-invasive, label-free quantifi cation of sciences. Due to its familiar format, most TC is still performed on energy expenditure and mitochondrial function, making it well suited two-dimensional polystyrene substrates. However, the need to achieve for measuring cell physiology and the pathophysiology of disease. In more accurate representations of the in vivo environment has driven response to a changing extracellular environment, disease and/or drug signifi cant research into alternative TC substrates. This Showcase will: exposure, cells remodel bioenergetic pathways in a matter of minutes review milestones in two-dimensional TC surface development; de- to drive phenotypic changes associated with these perturbations. scribe recent advances in surfaces designed for applications such as stem In the workshop learn how Extracellular Flux (XF) assays allow cell differentiation; and compare novel three-dimensional substrates you to quantify physiological changes in cellular bioenergetics by for generating more in vivo-like performance. Attention will be given measuring the two major energy yielding pathways, mitochondrial to the importance of the cellular microenvironment and interactions respiration and glycolysis. Learn about the XF advantages for measur- between neighboring cells and the extracellular matrix in cellular re- ing real-time metabolism; how the bioenergetic state of a cell defi nes sponses including differentiation, migration, and apoptosis. its physiology or pathophysiology; and how to perform XF assays to measure ATP turnover, substrate utilization, and mitochondrial Millipore Corporation 4:00 pm–6:00 pm, Room 201 function. Two Novel Human Neural Progenitor Systems from Millipore Level: Intermediate Seahorse Bioscience, Inc. 2:45 pm–3:30 pm, Room 206 Presenter: Stephen Kendall Advances in Measuring Cellular Bioenergetics Millipore Corporation Level: Intermediate Bioscience Division Presenter: David Ferrick 28820 Single Oak Drive Seahorse Bioscience, Inc. Temecula, CA 92590 16 Esquire Road Phone: (951) 676-8080 North Billerica, MA 01862 Fax: (800) 437-7502 Phone: (978)-671-1600 www.millipore.com Fax: (978)-671-1611 www.seahorsebio.com Stem cells show great promise not only as therapeutics but also as tools for research. Millipore now provides two novel human neural progeni- Extracellular Flux enables non-invasive, label-free quantifi cation of tor stem cells types for use in research. The fi rst, the ReNcell lines, are energy expenditure and mitochondrial function, making it well suited immortalized human progenitor cells isolated from two different regions for measuring cell physiology and the pathophysiology of disease. In of a fetal brain. The second are the ENStem-A human neural progenitor response to a changing extracellular environment, disease and/or drug cells. These are differentiated from the H9 human embryonic stem cells. exposure, cells remodel bioenergetic pathways in a matter of minutes Both types of cells are nestin-positive and are able to differentiate into to drive phenotypic changes associated with these perturbations. electrophysiologically active neurons and into astrocytes. 141 TUESDAY The American Society for Cell Biology 47th Annual Meeting December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

EXHIBITOR SHOWCASES WASHINGTON CONVENTION CENTER Nanonics Imaging Ltd. 6:15 pm–8:15 pm, Room 201 Millipore Corporation 6:15 pm–8:15 pm, Room 206 The World of Nanometric Light Microscopy The Art of Chromatin Immunoprecipitation Level: Advanced Level: Intermediate Presenter: Aaron Lewis Presenters Name: John Rosenfeld Nanonics Imaging, Ltd. Millipore Manhat Technology Park, Malcha 28820 Single Oak Dr. Jerusalem, 91487 Israel Temecula, CA 92590 Phone: (866) 220-6828 Phone: (800) 437-7500 Fax: (011) 972-2-6480-827 Fax: (800) 437-7502 www.nanonics.co.il www.millipore.com

Integrated optical imaging together with atomic force microscopy Chromatin immunoprecipitation (ChIP) is a powerful in vivo method (AFM) and its cousins are set to revolutionize nanometric characteriza- to evaluate interactions of nuclear proteins associated with discrete tion in cell biology. This workshop will introduce attendees to the com- regions of the genome. The ChIP technique is routinely used to ana- plete integration of these techniques that has resulted from Nanonics lyze changes in histone modifi cations that accompany gene activation pioneering scanned probe microscopy (SPM) systems with completely and silencing, and is a useful method for quantifying relative levels free optical axes that are fully integrated with optical microscopy. Such of histone modifi cations at specifi c loci. Additionally, ChIP allows SPM systems provide a variety of unique and standard modes of op- you to detect recruitment of particular transcription factors and other eration. The aim of this lecture is to provide the participant with an accessory effector proteins to a regulatory region. ChIP can also be up-to-date introduction to the state of the art in such instrumentation applied to studying compex formation at chromatin regions actively and applications as applied to cell and tissue imaging. undergoing replication, DNA repair, or epigenetic silencing. Until recently, researchers who wanted to interrogate a DNA se- quence for specifi c protein interactions were limited to biochemical assays and transfection analysis that bear little resemblance to the na- tive chromatin settings. ChIP enables measurement of chromatin as- sociation of endogenous proteins in their native context. However, the lengthy procedure that ChIP requires can be daunting to those who are new to the method. Fortunately, the homebrew method of chromatin immunoprecipitation has now been modeled into commercial products that provide easy to use bundled reagents and simple protocols with extensive troubleshooting support and built in controls. To navigate around some of the challenges presented by ChIP, Millipore invites you to come and gain more technical insight on protocol optimization and troubleshooting strategies for this method by focusing on: cell treat- ment, fragmentation, antibody selection and immunoprecipitation, purifi cation, and detection.

142 The American Society for Cell Biology 47th Annual Meeting TUESDAY December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

Poster Session 3 Halls A/B

Poster Set Up Monday 6:00 pm–6:30 pm

Posters Displayed Monday 7:00 pm–9:00 pm Tuesday 7:30 am–5:30 pm

Author Presentation Odd Boards 12:00 Noon–1:30 pm Even Boards 1:30 pm–3:00 pm

Poster Tear Down Tuesday 3:30 pm–4:00 pm

Board Numbers Session Titles Board Numbers Session Titles B1-14 Dynein II B340-361 Golgi Complex B15-26 Cytoskeleton–Membrane Interactions II B363-370 Growth Factors in Development B27-40 Unconventional Myosins II B371-386 Mammalian Development B41-60 Actin-associated Proteins II B387-407 Germ Cells and Fertilization B61-79 Kinesin II B409-426 Membrane Domains and Polarity B82-101 Pre-College and College Science Education B427-438 Golgi to Cell Surface Transport B103-119 Extracellular Matrix and Cell Signaling II B439-453 Endocytosis II B120-134 Focal Adhesions B454-472 ER to Golgi Transport B135-147 Organization and Regulation of the B473-486 Traffi cking in Polarized Cells Extracellular Matrix B487-497 Protein Targeting to the Cell Surface B148-158 Integrins B499-519 Cell Cycle Controls II B159-174 Diseases: Signaling B520-531 Oncogenes and Tumor Suppressors II B175-184 Diseases: Vascular B532-555 Growth Factors and Receptors B185-199 Cell Biology of the Immune System II B556-578 Mitosis & Meiosis III B200-222 Cancer III B579-593 Kinetochores II B223-245 Neuronal Disease II B594-608 Cytokinesis II B247-256 Endothelial Cells B610-632 Cell Motility – Regulation III B257-277 Molecular Biology and Detection B633-656 Nerve Cell Cytoskeleton B278-290 Imaging Technology B657-680 Conventional Myosin B291-304 Nuclear Matrix and Nuclear Architecture B681-691 Tubulin B305-320 Nuclear Import and Export Signals B692-718 Intermediate Filaments B323-339 Endosomes and Lysosomes B719-734 Actin

Annual Meeting Poster Presentation Guidelines • Presenters should ensure their posters are placed on the appropriate poster board for the duration of their as- signed poster sessions (the full 24-hour period). In cases of emergency, poster presenters who are unable to present should contact the ASCB at [email protected] to withdraw their abstract(s) before the Annual Meeting. In the case of withdrawn posters, a “WITHDRAWN” sign will be posted, along with the author’s contact information, on the poster board. • Poster presenters should stand at their poster locations during the appropriate 90-minute time slot—12:00 Noon–1:30 pm, or 1:30 pm–3:00 pm. (The specifi c information is included in the original poster notifi cation emails sent in September.) If presenters have to leave early, they should post a note on their boards stating when they will be available to answer attendee questions. • Cameras/Photography: Cameras and all other recording devices are strictly prohibited in all session rooms, on the Exhibit fl oor, and in all poster and oral presentation sessions.

143 TUESDAY The American Society for Cell Biology 47th Annual Meeting December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

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144 The American Society for Cell Biology 47th Annual Meeting TUESDAY December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org

Washington, DC Convention Center, Halls A/B

Dynein II 1667 B10 Regulation of the Microtubule- 1678 B21 Modulation of Endocytosis by the binding Behavior of Dynactin p150. S. ␤Heavy- spectrin C-terminal Segment 33 in Sivagurunathan, S. J. King; Molecular Biology & Association with Annexin B9. S. Lee,1 J. A. 1658 B1 Functional Differences in Biochemistry, University of Missouri–Kansas City, Williams,2 G. H. Thomas3; 1BMMB, The Cytoplasmic Dynein Variants for Axonal Kansas City, MO Pennsylvania State University, University Park, PA, Trafficking of Signaling Endosomes Revealed 2Department of Surgery, Vanderbilt University by Live Cell Imaging. J. Ha,1 K. W. Lo,1 K. R. 1668 B11 Dynactin Phosphorylation: Medical Center, Nashville, TN, 3Biology and BMB, Myers,1 T. M. Carr,1 M. K. Humsi,1 B. A. Rasoul,1 Multiple Targets and Potential Regulatory The Pennsylvania State University, University Park, R. A. Segal,2 K. K. Pfister1; 1Cell Biology, 1 1 Mechanisms. F. Cheong, K. Maier, A. PA University of Virginia, Charlottesville, VA, Sarkeshik,2 J. R. Yates,2 T. Schroer1; 1Biology, 2 Department of Neurobiology, Harvard Medical Johns Hopkins University, Baltimore, MD, 1679 B22 Mechanical Forces in School, Boston, MA 2Department of Cell Biology, The Scripps Research Phagocytosis. F. Mohammad-Rafiee, P. Sens; Institute, La Jolla, CA UMR 7083 - Physico-Chimie Theorique, CNRS- 1659 B2 Alterations in Retrograde ESPCI, Paris cedex 05, France Signaling Lead to Neuron Degeneration. E. 1669 B12 Dynactin Integrity and Arp1 1 1 1 1 Perlson, J. Ross, K. Wallace, R. Dixit, G. Stability Depend upon the Arp1 Binding 1680 B23 Drosophila Cip4/Toca-1 Couples 2 2 1 1 Jeong, R. Kalb, E. L. Holzbaur ; Department of Protein, Arp11. T. Yeh, T. A. Schroer; Biology, Membrane Trafficking and Actin Dynamics in Physiology, University of Pennsylvania, Johns Hopkins University, Baltimore, MD Wing Epithelial Cells. S. Bogdan; Institute of 2 Philadelphia, PA, Children's Hospital of Neurobiology, University of Muenster, Muenster, Philadelphia, Philadelphia, PA 1670 B13 Arp11 and p62 Modulate Dynein- Germany Dynactin Interaction in Aspergillus nidulans. J. 1660 B3 Bidirectional Motility of Vesicles In Zhang, L. Wang, L. Zhuang, L. Huo, S. Musa, S. 1681 B24 ABBA Regulates Actin and Vitro: Stochastic Switching vs. Regulated Li, X. Xiang; USUHS, Bethesda, MD Plasma Membrane Dynamics to Promote Radial 1 2 1 Runs? J. L. Ross, E. L. F. Holzbaur ; Physics Glia Extension. J. Saarikangas,1 J. Hakanen,1 P. Department, University of Massachusetts Amherst, 1671 B14 Evidence That Dynactin Mediates K. Mattila,1 M. Grumet,2 M. Salminen,1 P. 2 Amherst, MA, Physiology Department, University Offloading of Dynein from the Plus End of the Lappalainen1; 1Institute of Biotechnology, University of Pennsylvania, Philadelphia, PA Microtubule to the Cell Cortex. J. K. Moore, J. Li, of Helsinki, Helsinki, Finland, 2W. M. Keck Center J. A. Cooper; Cell Biology, Washington University, for Collaborative Neuroscience, Rutgers, State 1661 B4 Dynein-mediated Adenovirus St. Louis, MO University of New Jersey, New Jersey, NJ Transport: Unique Features of Pathogenic vs. Physiological Cargoes. K. H. Bremner, R. B. 1682 B25 Reconstitution of Filopodium-like Vallee; Pathology, Columbia University, New York, Cytoskeleton-Membrane Interactions II Structures on Giant Vesicles. A. P. Liu,1 D. L. NY Richmond,1 L. Maibaum,2 S. Pronk,3 P. Geissler,2 1672 B15 The Spatial and Temporal D. A. Fletcher3; 1Biophysics, University of 1662 B5 Dynein and LIS1 Transport the Regulation of “Frontness” and “Backness” California–Berkeley, Berkeley, CA, 2Chemistry, Entire Microtubule Cytoskeleton through in Proteins during Cytokinesis and Chemotaxis. C. University of California–Berkeley, Berkeley, CA, Migrating Neural Precursors, and Myosin IIb Janetopoulos, M. Sammons, C. Elzie; Biological 3Bioengineering, University of California–Berkeley, Brings Up the Rear. J. Tsai, K. H. Bremner, R. B. Sciences, Vanderbilt University, Nashville, TN Berkeley, CA Vallee; Pathology and Cell Biology, Columbia University, New York, NY 1673 B16 Role of Drebrin, a New Partner of 1683 B26 Cytoskeletal Reorganization and Par6, in Epithelial Cell Polarity. E. Bazellieres, L. New Cell Tip Formation in Shape-manipulated 1663 B6 The Lissencephaly 1 Protein Is a Lane-Guermonprez, A. Lebivic; IDBML, Marseille, Fission Yeast. C. Terenna, T. Makushok, M. Piel, Processivity Factor for Cytoplasmic Dynein. S. France P. T. Tran; Cell and Developmental Biology, L. Reck-Peterson,1 R. D. Vale2; 1Cell Biology, University of Pennsylvania, Philadelphia, PA Harvard Medical School, Boston, MA, 2Cellular and 1674 B17 WITHDRAWN Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 1675 B18 WITHDRAWN Unconventional Myosins II 1664 B7 Dynactin p150Glued New Isoforms: 1676 B19 Cytoskeletal Tropomyosins Tissue-specific Expression and Different Define Novel Membrane-associated Actin 1684 B27 The Functions of Myosin II and V Interaction with Microtubules. O. N. Filaments in Muscle Involved in Calcium Homologs in the Filamentous Fungus Zhapparova,1 L. V. Dergunova,2 N. M. Raevskaya,2 Regulation. E. C. Hardeman,1,2 A. J. Kee,1,2 C. Aspergillus nidulans. N. Taheri-Talesh, B. R. S. A. Bryantseva,1 N. A. Shanina,1 E. S. van der Poel,3 N. Vlahovich,1,4 G. S. Lynch,3 B. Oakley; Molecular Genetics, The Ohio State Nadezhdina3; 1Moscow State University, Moscow, Vhrovski,5 E. Kettle,1 G. Schevzov,5,2 F. Lemckert,5 University, Columbus, OH Russian Federation, 2Institute of Molecular J. Hook,5 R. Parton,6 P. W. Gunning5,2; 1Muscle 1685 B28 Myosin-1d Is a Major Component Genetics, RAS, Moscow, Russian Federation, Development Unit, Children's Medical Research of the Enterocyte Brush Border cytoskeleton. A. 3Institute of Protein Research, RAS, Moscow, Institute, Wentworthville NSW, Australia, 2Faculty of E. Benesh, R. E. McConnell, S. Mao, M. J. Tyska; Russian Federation Medicine, University of Sydney, Sydney, Australia, 3Department of Physiology, University of Cell and Developmental Biology, Vanderbilt 1665 B8 Dynactin Modulates Key Melbourne, Melbourne VIC, Australia, 4University of University Medical Center, Nashville, TN Parameters of Dynein Motility. J. R. Kardon,1 S. Western Sydney, Penrith NSW, Australia, 1686 B29 The Enterocyte Brush Border Is a L. Reck-Peterson,2 R. D. Vale3; 1Cellular & 5 Oncology Research Unit, The Children's Hospital Myosin-1a Powered Vesicle Generating Molecular Pharmacology, University of California, 6 at Westmead, Westmead NSW, Australia, Institute Organelle. R. E. McConnell, M. J. Tyska; Cell & San Francisco, San Francisco, CA, 2Cell Biology, for Molecular Biosciences, University of Developmental Biology, Vanderbilt University Harvard Medical School, Boston, MA, 3HHMI and Queensland, Brisbane QLD, Australia Medical Center, Nashville, TN Cellular & Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 1677 B20 Single Vesicle Analysis of 1687 B30 Kinetics of Myo1c Association to Endocytic Fission Along Microtubules and and Dissociation from Phosphoinositide 1666 B9 The Basics of Dynein Motor Actin In Vitro. S. Sarkar, A. W. Wolkoff, J. W. Containing Vesicles. J. M. Dawicki-McKenna, E. Processivity: Analyses of the Dynactin Basic Murray; Anatomy and Structural Biology, Albert M. Ostap; Physiology, University of Pennsylvania Domain. M. M. Kincaid, A. Green, S. J. King; Einstein Collge of Medicine, Bronx, NY School of Medicine, Philadelphia, PA School of Biological Sciences, University of Missouri–Kansas City, Kansas City, MO 1688 B31 Myosin-I Can Act as a Force Sensor. J. M. Laakso, H. Shuman, E. M. Ostap; Physiology, University of Pennsylvania School of Medicine, Philadelphia, PA

145 TUESDAY The American Society for Cell Biology 47th Annual Meeting Poster Session 3 B32–B60 December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org

1689 B32 MYO1 Affects Developmentally Actin-associated Proteins II 1708 B51 Dematin Functions as a Regulated Elimination of the Macronucleus Suppressor of RhoA Activation and Regulates during Conjugation in Tetrahymena Cell Shape, Motility, and Wound Healing In Vivo. 1698 B41 Modulation of Actin Mechanics thermophila. J. Garcés,1 R. H. Gavin2; 1Biology, M. Mohseni, A. Chishti; Pharmacology, UIC Cancer by Caldesmon and Tropomyosin. M. Greenberg,1 CUNY Honors College, Brooklyn, NY, 2Biology, Center, College of Medicine, University of Illinois, C. Wang,2 W. Lehman,1 J. Moore1; 1Physiology Brooklyn College–CUNY, Brooklyn, NY Chicago, IL and Biophysics, Boston University, Boston, MA, 2 1690 B33 Acanthamoeba Myosin IC and Boston Biomedical Research Institute, Watertown, 1709 B52 Expression and Localization MA PIP2 Colocalize In Vivo. H. Brzeska, E. D. Korn; Studies of Annexin 5a in the Inner Ear of the LCB, NHLBI, NIH, Bethesda, MD Mouse. M. C. Drummond,1 I. A. Belyantseva,2 M. 1699 B42 Tropomodulin 1 Is a Novel Zhu,3 K. A. Friderici4; 1Genetics Program, Michigan Substrate of TRPM7 Channel-Kinase. M. V. 1691 B34 A Circadian Clock and Light In State University, East Lansing, MI, 2National Dorovkov,1 S. Beznosov,2,3 S. Shah,2 A. S. Vivo and Elevated cAMP and Light In Vitro Institute on Deafness and Other Communication Kostyukova2; 1Pharmacology, Robert Wood Regulate the Distribution of Myosin III and Actin Disorders, Rockville, MD, 3Cell and Molecular Johnson Medical School, Piscataway, NJ, in Limulus Photoreceptors. R. E. Dorr, N. Biology, Michigan State University, East Lansing, 2Neuroscience and Cell Biology, Robert Wood Robinson, B. Battelle; Whitney Laboratory, MI, 4Microbiology and Molecular Genetics, Johnson Medical School, Piscataway, NJ, 3Institute University of Florida, St. Augustine, FL Michigan State University, East Lansing, MI of Protein Research, RAS, Pushchino, Russian 1692 B35 Myosin3b Localization in the Federation 1710 B53 The LIM Domains of Plant LIM Mouse Retina. C. Katti, B. Battelle; The Whitney Proteins are F-Actin Binding and Bundling 1700 B43 Dimerized AtFH8 Can Bundle Laboratory, University of Florida, St. Augustine, FL Modules. A. A. Steinmetz, C. Thomas, C. Actin Filaments In Vitro and In Vivo. C. Guo, X. Hoffmann, M. Dieterle, F. Moreau, S. Gatti, J. 1693 B36 Kinase-dependent Regulation of Xue, H. Ren; College of Life Science, Beijing Papuga, S. Tholl; CRP-Sante, Luxembourg, the Myosin IIIA Motor. C. M. Yengo,1 J. Moore,1 Normal University, Beijing, China A. Dose,2 B. Burnside2; 1Biology, University of Luxembourg 1701 B44 Differential Regulation of North Carolina at Charlotte, Charlotte, NC, 1711 B54 Expression and Localization of 2 Macropinocytosis by Isoforms of Abi1/ Molecular and Cell Biology, University of Lasp-2 in Nervous System. A. G. Terasaki,1 T. Hssh3bp1. P. Cui,1 X. Xiong,1 S. Hossain,1 S. California–Berkeley, Berkeley, CA Kaneko,1 J. Suzuki,1 H. Akiyama,2 H. Kamiguchi2; Heck,2 L. Kotula1; 1Laboratory of Cell Signaling, 1Chiba University, Chiba, Japan, 2BSI, RIKEN, 1694 B37 Impaired Proximal Tubular New York Blood Center, New York, NY, 2Flow Wako, Japan Endocytosis and Proteinuria in Mice Lacking Cytometry Core, New York Blood Center, New 1 2 2 Myosin-VI. N. Gotoh, Q. Yan, Z. Du, D. York, NY 1712 B55 Identification of Cancer-related 3 4 1 Biemesderfer, M. Kashgarian, M. S. Mooseker, Protein Targets Regulated by MicroRNA-21 in 2 1 1702 B45 Fascin Dynamics in Filopodia. Y. T. Wang ; Cell Biology, Yale University, New Human Hepatocellular Carcinoma. L. Meng,1,2 T. 2 S. Aratyn,1 T. E. Schaus,1 E. W. Taylor,1 M. Haven, CT, Cellular and Molecular Physiology, Patel1; 1Department of Internal Medicine, Ohio 3 Gardel,2 G. G. Borisy3; 1Cell and Molecular Yale University, New Haven, CT, Internal State University Medical Center, Columbus, OH, Medicine, Yale University, New Haven, CT, Biology, Northwestern University, Chicago, IL, 2 2 Texas Academy of Math & Science, University of 4Pathology and Molecular, Cellular and Physics, Institute of Biophysical Dynamics, 3 North Texas, Denton, TX Developmental Biology, Yale University, New University of Chicago, Chicago, IL, Marine Haven, CT Biological Laboratory, Woods Hole, MA 1713 B56 Vinculin Contributes to Tumor Cell Invasion by Regulating Contractile 1703 B46 Drebrin Regulates Podosomal 1695 B38 Mechanistic Dissection of Myosin Activation. C. T. Mierke, D. Paranhos-Zitterbart, P. Adhesions in Human Endothelial Cells. V. van VI Function in Actin Structure Stabilization Kollmannsberger, G. Diez, C. Raupach, B. Fabry, Vliet,1 A. Osiak,1 W. Peitsch,2 A. Schröder,1 B. during Drosophila Spermatid Individualization. W. H. Goldmann; Medical Physics and Technology, 1,2 1 1 1 Ebbing,1 S. Linder1; 1LMU, Munich, Germany, T. Noguchi, D. J. Frank, M. Isaji, K. G. Miller ; University of Erlangen–Nuremberg, Erlangen, 1 2Universität Heidelberg, Mannheim, Germany Biology, Washington University, St. Louis, MO, Germany 2Center for Developmental Biology, Riken, Kobe, 1704 B47 Tyrosine Phosphorylation of Japan 1714 B57 Expression of Diacylglycerol WASP Controls Actin Assembly and Sealing Kinase Isozymes in Rat Aortic Smooth Muscle Ring Formation in Osteoclasts-Analyses with 1696 B39 A Novel Rearrangement within Cells. T. Nakano,1 K. Goto,2 I. Wakabayashi1; Different WASP Domains. T. Ma, M. A. Chellaiah; the Myosin VI Motor Provides a New 1Environmental and Preventative Medicine, Hyogo Biomedical Science Department, University of Mechanism to Increase the Size of the Myosin College of Medicine, Nishinomiya, Japan, 1 1 Maryland, Baltimore, Baltimore, MD Powerstroke. J. Menetrey, P. Llinas, M. 2Anatomy and Cell Biology, Yamagata University Mukherjea,2 H. Sweeney,2 A. M. Houdusse1; 1UMR 1705 B48 Adhesion-dependent Regulation School of Medicine, Yamagata, Japan 144 CNRS, Institut Curie, Paris, France, of Cell Edge Protrusions Requires Arg Kinase 2Physiology Department, University of 1715 B58 A New Mechanism for Stress and Cortactin. S. Lapetina; Molecular Biophysics Pennsylvania School of Medicine, Philadelphia, PA Fiber Repair. M. A. Smith,1 E. Blankman,1 M. & Biochemistry, Yale University, New Haven, CT Gardel,2 C. M. Waterman,3 M. C. Beckerle1; 1697 B40 Amoeba proteus Myosin VI- 1 1706 B49 Mutually Exclusive Subcellular Huntsman Cancer Institute, University of Utah, Immunoanalog Is Involved in Vesicular 2 Localization of Active Rho and Arp2 mRNA as Salt Lake City, UT, Physics, University of Chicago, Trafficking and/or Maintaining Actin 3 Visualized with FRET-FISH. L. A. Mingle,1 M. Chicago, IL, Cell Biology and Physiology Center, Cytoskeleton Dynamics. M. Sobczak,1 A. Wasik,2 Barroso,2 G. Bonamy,3 G. Liu1; 1Cell Biology & National Heart, Lung and Blood Institute, Bethesda, W. Klopocka,1 Z. Madeja,3 M. Redowicz1; Cancer Research, Albany Medical College, Albany, MD 1Department of Biochemistry, Nencki Institute of NY, 2Center for Cardiovascular Sciences, Albany Experimental Biology, Warsaw, Poland, 1716 B59 Estimate of Severing Rate of Medical College, Albany, NY, 3Department of 2Department of Cell Biology, Nencki Institute of Actin Filaments during Actin Assembly In Vivo. Molecular & Cell Biology, Genomic Institute of the Experimental Biology, Warsaw, Poland, T. Wakatsuki,1 M. J. Pablo,1 E. Elson2; 1Physiology Novartis Research Foundation, San Diego, CA 3Department of Cell Biology, Faculty of and Bioengineering Biotechnology Center, Medical Biochemistry, Biophysics and Biotechnology, 1707 B50 Determination of Cdc42-Effector College of Wisconsin, Milwaukee, WI, Jagiellonian University, Cracow, Poland 2Biochemistry and Molecular Biophysics, Binding Constants, Kd, in Live Cells by Fluorescence Cross-Correlation Spectroscopy Washington University, St. Louis, MO (FCCS). S. Thankiah,1 L. Ping,2 F. Hwee,2 W. Bu,1 1717 B60 The Pro-Apoptotic Protein Par-4 K. Lim,1 T. Wohland,2 S. Ahmed1; 1Regenerative Facilitates Smooth Muscle Contractility by Medicine, Institute of Medical Biology, Singapore, Acting as a Cytoskeletal Scaffold for ZIPK. S. 2Department of Chemistry, National University of Vetterkind,1,2 K. G. Morgan1,2; 1Sargent College, Singapore, Singapore Boston University, Boston, MA, 2Boston Biomedical Research Institute, Watertown, MA

146 The American Society for Cell Biology 47th Annual Meeting TUESDAY December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org Poster Session 3 B61–B93

Kinesin II 1730 B73 Novel Role for Microtubule 1740 B85 Project Hands-On: A Novel Motors in Cellular Stress with Implications in Program to Increase Science in the Elementary Ribosomal Transport. K. M. Bartoli,1 M. Ashfag,2 Classroom. M. L. Marquette; NASA Johnson 1718 B61 Subunit Interactions in J. Weber,2 J. Woolford,3 W. S. Saunders1; Space Center, Houston, TX Heterodimeric Ncd Constructs. E. Kocik, K. 1Biochemistry and Molecular Genetics, University Skowronek, A. Kasprzak; Biochemistry, Nencki of Pittsburgh, Pittsburgh, PA, 2Washington 1741 B86 Microarrays for the Masses: Institute of Experimental Biology, Warsaw, Poland University School of Medicine, St. Louis, MO, Pedagogical Resources for High School 1,2 3,2 3 through College. A. Campbell, L. J. Heyer, M. 1719 B62 A Kinesin with Dual Motoring and Department of Biological Sciences, Carnegie L. S. Ledbetter,4,2 L. L. M. Hoopes,5,2 T. T. Depolymerizing Activities Regulates Plus-end Mellon University, Pittsburgh, PA Eckdahl,6,2 A. G. Rosenwald,7,2 E. R. Fowlks,8,2 N. Microtubule Dynamics in Budding Yeast. M. L. 1731 B74 Characterising the Kinesin- Dovidio,3 M. R. Gordon,3 D. Moskowitz,3 M. L. Gupta,1 P. Carvalho,1 D. M. Roof,2 D. Pellman1; dependent Transport of RNAs and Other Cowell,1 J. Abele,3 B. Akin,3 G. Taylor,3 D. Choi,1 1Pediatric Oncology, Dana-Farber Cancer Institute/ Cargoes. P. Loiseau, I. M. Palacios; Department of P. Karnik,3 P. Lowry,1 J. M. Madden,1 E. E. Harvard Medical School, Boston, MA, 2Department Zoology, University of Cambridge, Cambridge, Oldham,1,3 B. Pierce,1 A. Amore,1 S. Bossie,1 M. of Animal Biology, University of Pennsylvania, United Kingdom Citrin,1 E. Cobain,1 M. McDonald,1,9 M. Sole,1 E. Philadelphia, PA Wilson,1 M. Gemberling,1 K. DeCelle,1 K. Acker,1 L. 1732 B75 The Amyloid-␤ Precursor Protein 1 1 10 1720 B63 WITHDRAWN Buckwold, B. Whigham, C. A. Zanta, K. Is Transported into Axons as Cleaved Gabric,11 B. Kittinger,1 L. Adler,12 A. Ryan,1 W. T. 1721 B64 Visualisation of Kinesin-13 Polypeptides Rather than Full-Length Protein. Hatfield1,3; 1Biology, Davidson College, Davidson, Activity at Microtubule Ends. C. A. Moores,1 A. Z. Muresan, V. Muresan; Pharmacology and NC, 2Genome Consortium for Active Teaching, Mulder,2 R. A. Milligan2; 1Department of Physiology, UMDNJ–New Jersey Medical School, Davidson, NC, 3Mathematics, Davidson College, Crystallography, Birkbeck College, London, United Newark, NJ Davidson, NC, 4Biology, College of the Holy Cross, Kingdom, 2Department of Cell Biology, The Scripps Worcester, MA, 5Biology, Pomona College, 1733 B76 Cooperative Versus Independent Research Institute, La Jolla, CA Pomona, CA, 6Biology, Missouri Western State Transport of Different Cargoes by Kinesin-1. J. University, St. Joseph, MO, 7Biology, Georgetown 1722 B65 Structural Features of the W. Hammond,1 K. Griffin,1 J. Stuckey,2 K. J. University, Washington, DC, 8Biology, Hampton Microtubule Important for MCAK Activity. K. M. Verhey1; 1Cell and Developmental Biology, University, Hampton, VA, 9Physics, Davidson Hertzer, C. E. Walczak; Medical Sciences Program, University of Michigan, Ann Arbor, MI, 2Biological College, Davidson, NC, 10Howard Hughes Medical Chemistry and Life Sciences Institute, University of Indiana University, Bloomington, Bloomington, IN Institute Biotechnology Education and Outreach Michigan, Ann Arbor, MI 1723 B66 Kinesin-14 Family Proteins HSET/ Program, University of Illinois at 11 XCTK2 Play a Role in Spindle Length Control, 1734 B77 Levels of the Directionality Urbana–Champaign, Urbana, IL, Hinsdale Central 12 Centrosome Attachment to Spindles, and Determinant Halo Affect Kinesin-1 Activity High School, Hinsdale, IL, Montgomery County Chromosome Alignment. S. Cai, S. Ems- during Plus-End Transport of Lipid Droplets in Public Schools, Rockville, MD Drosophila Embryos. S. L. Tran,1 M. A. Welte2,1; McClung, C. Walczak; Indiana University, 1742 B87 The Organic Chemistry 1Biology, Brandeis University, Waltham, MA, Bloomington, IN Prerequisite Has Minimal Impact on Student 2Biology, University of Rochester, Rochester, NY 1724 B67 Protein 4.1R Binding Effector Performance in Introductory Biochemistry. R. Domain of Human Dlg Tumor Suppressor Acts 1735 B78 Microtubule Movement In Vivo by Wright; Department of Genetics, Cell Biology, and as a Switch That Relieves Auto-Inhibition of Conventional Kinesin. H. Kim,1 I. M. Kulic,2 A. E. Development, University of Minnesota, Kinesin-3 Motor GAKIN/KIF13B. T. Hanada, K. H. X. Brown,3 V. I. Gelfand1; 1Cell and Molecular Minneapolis, MN Yamada, A. H. Chishti; Department of Biology, Northwestern University, Chicago, IL, 2School of Engineering and Applied Sciences, 1743 B88 The Genomics Education Pharmacology and UIC Cancer Center, University 1 C. D. Shaffer,1 W. Harvard University, Cambridge, MA, 3Physics and Partnership. S. C. R. Elgin, of Illinois College of Medicine, Chicago, IL Leung,1 J. Buhler,2 E. Mardis,3 D. Lopatto4; Astronomy and Nano/Bio Interface Center, 1 1725 B68 The Kinesin-3 Family Member Biology, Washington University, St. Louis, MO, University of Pennsylvania, Philadelphia, PA 2 KIF1A Is Required for the Transport of a Subset Computer Science & Engineering, Washington 3 of Synaptic Vesicle Proteins. J. D. Petersen, S. 1736 B79 Mechanisms for Kinesin-1 Driven University, St. Louis, MO, Genetics, Washington 4 Kaech, G. Banker; CROET, Oregon Health and Cytoplasmic Streaming in Drosophila Oocytes. University, St. Louis, MO, Psychology, Grinnell Sciences University, Portland, OR P. Moua,1 W. M. Saxton2; 1Biology, Indiana College, Grinnell, IA University, Bloomington, IN, 2MCD Biology, 1744 B89 Teaching Experience About 1726 B69 Establishment of New University of California, Santa Cruz, Santa Cruz, Immune System. I. T. C. Novak; Biologia Celular, Hypomorphic Mouse Model for KIF1A Molecular CA Motor. M. Dong, Y. Tanaka, S. Niwa, Y. Takei, N. Histologia y Embriologia, Facultad de Ciencias Hirokawa; Department of Cell Biology and Medicas, Universidad Nacional de Cordoba, Anatomy, University of Tokyo Graduate School of Pre-College and College Science Education Cordoba, Argentina Medicine, Tokyo, Japan 1745 B90 Design Principles for Effective 1737 B82 Pre-College Science Education: Molecular Animations. M. K. Reinke, N. J. Greco, 1727 B70 The Role of Microtubule Motors Basic Research as a Teaching Method for High J. Honts; Biology, Drake University, Des Moines, IA and Endocytic Traffic in Cell Migration. B. M. School Science. S. F. S. Neuroscience Research Bola, M. J. Wozniak, N. Flores-Rodriguez, P. G. Course, M. C. Fields; Science, Sidwell Friends 1746 B91 High Resolution Video Imaging Woodman, M. J. Humphries, V. J. Allan; Faculty of School, Washington, DC Equipment Promotes Rapid Learning in the Life Sciences, University of Manchester, Histology Laboratory. V. D. C. Shields; Biological 1738 B83 From Sleep to Action Potentials: Manchester, United Kingdom Sciences, Towson University, Towson, MD Experiments on the Ventral Nerve Cord of 1728 B71 A Quantitative Cell-based High- Worms in a High School Biology Class. A. J. 1747 B92 A Research-oriented Cell Culture Content Screening Assay for the Study of Cell Ordoobadi; Sidwell Friends School, Washington, Course for Undergraduates Using Inexpensive Polarity and Migration Using Automated Wound DC Methodologies. L. Wang, Y. Myzyri, I. Xhai, T. A. 1 E. Del Nery,1 M. Healing Assays. A. Lescure, Lyerla; Biology, Clark University, Worcester, MA Swiatek,2 P. Benaroch,1 J. Camonis,1 F. Perez1; 1739 B84 Addressing the STEM Education 1The Biophenics Laboratory, Translational Biology Crisis: Teacher and Student Programs. M. A. 1748 B93 Yeast and Oxygen: Building an Department, Institut Curie, Paris, France, 2GE Sognier,1,2 C. W. Houston3; 1University of Texas Undergraduate Research Community Around a Healthcare Life Sciences, Piscataway, NJ Medical Branch, Galveston, TX, 2Universities Common Research Theme. C. M. O’Connor; Space Research Association, NASA Johnson Biology, Boston College, Chestnut Hill, MA 1729 B72 Kinesin Knockouts in Space Center, Houston, TX, 3Office of Educational Dictyostelium. D. K. Nag, I. Tikhonenko, I. Soga, Outreach, University of Texas Medical Branch, M. Koonce; Molecular Medicine, Wadsworth Galveston, TX Center, Albany, NY

147 TUESDAY The American Society for Cell Biology 47th Annual Meeting Poster Session 3 B94–B122 December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org

1749 B94 Do Instant Feedback Techniques Extracellular Matrix and Cell Signaling II 1767 B113 Fyn Dysregulation Accompanies Improve the Student and Instructor Experience Delayed Oligodendrocyte Differentiation in in Introductory Biology Courses? B. A. Fall,1 S. Laminin-deficient Brains. J. Relucio, I. 1757 B103 p190RhoGAP Is Required for H. Cotner,1 M. D. Decker,1 P. M. Baepler,2 J. Tzvetanova, W. Ao, H. Colognato; Pharmacology, Ductal Morphogenesis in Breast Epithelial Walker,3 S. Wick4; 1Biology Program, University of Stony Brook University, Stony Brook, NY Cells. S. M. Ponik,1 M. A. Wozniak,2 P. J. Keely1; Minnesota, Minneapolis, MN, 2Center for Teaching 1Pharmacology, University of Wisconsin–Madison, and Learning, University of Minnesota, 1768 B114 The Egf Receptor Regulates Stat Madison, WI, 2Bioengineering, University of Minneapolis, MN, 3Digital Media Center, University Activity Following Fibronectin-dependent Cell Pennsylvania, Philadelphia, PA of Minnesota, Minneapolis, MN, 4Biology Program Adhesion. N. G. Balanis; Physiology & Biophysics, Case Western Reserve University, Cleveland, OH and Plant Biology, University of Minnesota, 1758 B104 p38 Regulates Nuclear Minneapolis, MN Accumulation of Myocardin-related 1769 B115 EGF Influences the Sub-cellular Transcription Factor during Epithelial- 1750 B95 Demystifying Research and Distribution of Alpha Actinins and NFkB in Myofibroblast Transition. A. Sebe,1,2 A. Masszi,1,2 Humanizing Researchers by Teaching with A431 Cells Spread on Fibronectin. A. I. Mucsi,1 L. Rosivall,1 A. Kapus2; 1Department of 1 1 1 Primary Literature - the C.R.E.A.T.E. Approach. Bolshakova, O. Petukhova, L. Turoverova, D. Pathophysiology, Semmelweis University, 1 2 1 1 S. G. Hoskins,1 L. M. Stevens2; 1Biology, City Tentler, K. I. Magnusson, G. Pinaev ; Cell Budapest, Hungary, 2Department of Surgery, St. College of the CIty University of New York, New Cultures, Institute of Cytology, St. Petersburg, Michael’s Hospital, University of Toronto, Toronto, 2 York, NY, 2Section of Molecular, Cell and Russian Federation, Medical Microbiology, ON, Canada Developmental Biology, University of Texas, Austin, Linkoping University, Linkoping, Sweden TX 1759 B105 The Role of FilGAP-Filamin A 1770 B116 Growth Interactions in Mechanoprotection. Y. Shifrin,1 P. 1751 B96 Personal and Attitudinal Factor as a Regulator of Mammary Epithelial D. Arora,1 Y. Ohta,2 C. A. G. McCulloch1; 1CIHR Predictors of Performance on Analytical Cell Adhesion and Survival during Lactogenic Group in Matrix Dynamics, University of Toronto, 1 1 Reasoning Tasks in Cell Biology: Helping Differentiation. B. Morrison, C. Jose, B. Toronto, ON, Canada, 2Department of Biosciences, 1 2 1 1 Students Improve Their Study Methods. W. S. Khurana, N. Kenney, M. Cutler ; Pathology, Kitasato University, Kitasato, Japan Bradshaw,1 J. Nelson,2 K. Boren,3 J. D. Bell2; Uniformed Services University of Health Sciences, 2 1 Bethesda, MD, Biology, Hampton University, Microbiology and Molecular Biology, Brigham 1760 B106 Precenilin Enhancer 2 (PEN2) Is 2 Hampton, VA Young University, Provo, UT, Physiology and Involved in Adipocyte Differentiation. S. M. Lee, Developmental Biology, Brigham Young University, H. M. Kim, H. Y. Park, S. J. Moon, M. J. Kang; 1771 B117 Osteoblasts Derived from Nmp4/ 3Biology, Brigham Young University, Provo, UT, Department of Animal Science, Chonnam National CIZ Knockout Mice Exhibit an Enhanced Shear Provo, UT University, Gwangju, Republic of Korea Stress-induced Increase in COX-2 Expression. E. J. Rodenberg,1 J. P. Bidwell,2 F. M. Pavalko1; 1752 B97 Incorporation of Civic 1761 B107 Filamin A-␤1 Integrin 1Cellular and Integrative Physiology, Indiana Engagement Activities in Core Biology Majors' Interactions Regulate Myosin Activity to Tune University School of Medicine, Indianapolis, IN, Courses. R. M. Seiser, K. Wentz-Hunter; Cellular Contractility and Tubulogenesis in 2Anatomy and Cell Biology, Indiana University Roosevelt University, Schaumburg, IL Response to 3D Matrix Density. S. Gehler,1 Y. School of Medicine, Indianapolis, IN Lad,2 M. Baldassarre,2 D. A. Calderwood,2 P. J. 1753 B98 Teaching Modeling and Keely1; 1Pharmacology, University of Wisconsin, Quantitative Cell Biology. R. M. Holmes,1,2 A. E. 1772 B118 NRAGE/MAGE-D1, a MAGE Madison, WI, 2Pharmacology, Yale University Cowan,2 I. I. Moraru,2 J. Schaff,2 B. M. Family Member Is an Anoikis Suppressor. S. School of Medicine, New Haven, CT Slepchenko,2 L. M. Loew2; 1Center for Kumar, S. M. Frisch; Biochemistry, West Virginia University, Morgantown, WV Computational Science, Boston University, Boston, 1762 B108 ␤Pix Is Important for Neural 2 MA, Center for Cell Analysis and Modeling, Tube Closure and Placenta Formation during 1773 B119 Endogenous Cannabinoid University of Connecticut Health Center, 1 1 1 Early Development. H. Baek, S. Lee, J. Kim, T. Anandamide: A Novel Regulator Angiogenic 1 2 1 1 Farmington, CT Kim, M. Kim, D. Park ; School of Biological Switch. I. Johnson,1 S. Hilderbrand,1 M. Schaller,2 Sciences, Seoul National University, Seoul, 3 1 1754 B99 Semester-Long Application-based S. Mukhopadhyay ; Neuroscience Research Republic of Korea, 2Department of Biological Investigative Project, in Modern Cell Biology, Program, Biomedical Biotechnology Research Science, Inha University, Incheon, Republic of for Broader Learning Outcomes. N. Philips; Institute, North Carolina Central University, Korea 2 Fairleigh Dickinson University, Teaneck, NJ Durham, NC, Cell & Developmental Biology, University of North Carolina–Chapel Hill School of 1763 B109 C-Terminal Src Kinase, Csk, 1755 B100 Incorporating New Technology Medicine, Chapel Hill, NC, 3Neuroscience & Regulates Proliferation, Survival and into Online Learning: Applications and Student Cancer Research Program, Biomedical Differentiation during Oligodendrocyte Satisfaction with Web-Conferencing Biotechnology Research Institute, North Carolina Development. I. D. Tzvetanova, H. Colognato; Technology. K. Obom,1 R. Lessick,2 T. Koval,1 P. Central University, Durham, NC Pharmacology, Stony Brook University, Stony Cummings2; 1Advanced Biotechnology Studies, Brook, NY Johns Hopkins University, Rockville, MD, 2 Focal Adhesions Advanced Biotechnology Studies, Johns Hopkins 1764 B110 Stretch-induced Activation of University, Baltimore, MD AMP Kinase in the Lung Requires Dystroglycan. G. R. S. Budinger,1 D. Urich,1 P. J. 1774 B120 Retrograde Fluxes of Focal 1756 B101 Frontiers in Human Embryonic DeBiase,2 P. S. Chiarella,1 Z. Burgess,1 C. Baker,1 Adhesion Proteins in Response to Cell Stem Cells: An Advanced Laboratory Course. S. Soberanes,1 G. M. Mutlu,1 J. C. Jones2; Migration and Mechanical Signals. W. Guo, Y. D. Carlisle,1,2 C. Navara,1,2 R. Carrie,2 J. Mich- 1Division of Pulmonary and Critical Care Medicine, Wang; Physiology, University of Massachusetts Basso,2 C. Simerly,1,2 D. McFarland,2 E. Jacoby,2 Northwestern University, Chicago, IL, 2Cell and Medical School, Worcester, MA A. Ben-Yehudah,1,2 R. Pedersen,3 G. Schatten1,2; Molecular Biology, Northwestern University, 1Department of Ob/Gyn and Reproductive 1775 B121 Role of SNARE Mediated Chicago, IL Sciences, University of Pittsburgh, Pittsburgh, PA, Membrane Trafficking in Focal Adhesion 2Pittsburgh Development Center, Pittsburgh, PA, 1765 B111 Dystroglycan Is Necessary for Dynamics. N. Sharma, M. Skalski, M. J. Kean, M. 3Department of Surgery, University of Cambridge, Optimal Production and the Regulation G. Coppolino; Molecular & Cellular Biology, Cambridge, United Kingdom of MAPK and PI3K Signaling Pathways in University of Guelph, Guelph, ON, Canada Oligodendrocytes. J. W. Galvin, H. Colognato; 1776 B122 Syndecan-4 Promotes De Novo Pharmacology, Stony Brook University, Stony Focal Adhesion Formation. M. Frigault,1 B. Brook, NY Matthews,2 M. McKenna,1 E. Morse,1 S. 1 2 1 1 1766 B112 JNK-Dependent Regulation of Sreepathi, D. Ingber, R. Bellin ; Department of Polarization in Primary Mouse Mammary Cells. Biology, Holy Cross College, Worcester, MA, 2 J. A. Whyte, L. Thornton, E. McArdle, F. Martin; Department of Pathology, Children's Hospital and School of Biomolecular and Biomedical Sciences, Harvard Medical School, Boston, MA University College Dublin, Dublin 4, Ireland

148 The American Society for Cell Biology 47th Annual Meeting TUESDAY December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org Poster Session 3 B123–B150

1777 B123 Endothelial Cell Adhesion in 1787 B133 Protein 4.1R Is Important for 1796 B142 Maspin Increases Activation of Three Dimensions. P. S. Arauz,1 J. H. Hoh,2 L. H. Actin Cytoskeletal Organization and Cell Plasminogen by Corneal Stromal Fibroblasts Romer3; 1Biomedical Engineering, Johns Hopkins Motility of Mouse Keratinocytes. R. A. Hughes, and . S. S. Twining, D. J. University, Baltimore, MD, 2Physiology and N. Mohandas, X. An; Red Cell Physiology, New Warejcka; Biochemistry, Medical College of Chemical Engineering, Johns Hopkins University, York Blood Center, New York, NY Wisconsin, Milwaukee, WI Baltimore, MD, 3Anesthesiology and Critical Care Medicine, Cell Biology, Pediatrics, Johns Hopkins 1788 B134 Electron Beam Patterned 1797 B143 Tenascin-C Is Upregulated at the University, Baltimore, MD Fibronectin Nanodots That Support Focal End of the Cell Cycle in Proliferating NIH 3T3 Adhesion Formation. D. Pesen,1 W. F. Heinz,2 J. Fibroblasts. M. Halter,1 B. L. Stottrup,2 K. J. 1778 B124 Plectin Isoform 1f Mediates L. Werbin,2 D. B. Haviland1; 1Applied Physics, KTH Langenbach,3 A. Tona,4 A. L. Plant,1 J. T. Elliott1; Targeting of Vimentin Filaments to Fibrillar and Royal Institute of Technology, Stockholm, Sweden, 1Cell and Tissue Measurements Group, National Focal Adhesions in Mouse Fibroblasts. G. 2Physiology, Johns Hopkins University, Baltimore, Institute of Standards and Technology, Burgstaller, M. Gregor, G. Wiche; Molecular Cell MD Gaithersburg, MD, 2Physics, Augsburg College, Biology, MFPL - University of Vienna, Vienna, Minneapolis, MN, 3BEI Resources, Manassas, VA, Austria 4SAIC, Arlington, VA Organization and Regulation of the Extracellular 1779 B125 pH Allosterically Regulates Talin Matrix 1798 B144 MMP2 Remodelling of the Lens Binding to Actin for Focal Adhesion Stability ECM Accompanies FGF-2 Release and 1 2 and Cell Migration. J. Srivastava, G. Barreiro, 1789 B135 Ultrastructural Organization of Epithelial Cell Survival and Proliferation. R. A. 2 2 1 1 1 1 2 M. J. S. Kelly, M. P. Jacobson, D. L. Barber ; Collagen Fibrils of Shark Mandible. T. Sawada,1 Quinlan, F. Tholozan, M. Goldberg, J. Wu ; 1 1 Cell and Tissue Biology, University of California, S. Inoue2; 1Ultrastructural Science, Tokyo Dental School of Biological and Biomedical Sciences, San Francisco, San Francisco, CA, College, Chiba, Japan, 2Anatomy and Cell Biology, Durham University, Durham, United Kingdom, 2 2 Pharmaceutical Chemistry, University of California, McGill University, Montreal, PQ, Canada Department of Engineering, Durham University, San Francisco, San Francisco, CA Durham, United Kingdom 1790 B136 Mathematically Modeling 1780 B126 Down Regulation of Focal Collagen Lattice Contraction by Fibroblasts. J. 1799 B145 Immunocytochemical Adhesion Kinase in Osteoblasts Inhibits the Dallon,1 H. P. Ehrlich2; 1Mathematics, Brigham Localization of a Glutactin-like Protein in Response to Fluid Shear Stress. S. R. L. Young, Young University, Provo, UT, 2Plastic Surgery, Drosophila: Evidence for Diversity of F. M. Pavalko; Physiology, Indiana University Milton S. Hershey Medical Center Hershey, Extracellular Matrix. S. Guillemette, R. Humphrey, School of Medicine, Indianapolis, IN Hershey, PA J. O. Vigoreaux; Biology, University of Vermont, Burlington, VT 1781 B127 Focal Adhesion Targeting of v- 1791 B137 Hypoxia Reduces Collagen Crk Is Essential for FAK Phosphorylation and Fiber Density in Human Breast and Prostate 1800 B146 Trafficking and Regulation of Cell Migration in Mouse Embryo Fibroblasts Cancer Xenografts. K. Glunde,1 M. Solaiyappan,1 Extracellular Polysaccharide Capsule in Deficient Src Family Kinases or p130CAS. B. B. O’Rourke,2 V. Raman,1 Z. M. Bhujwalla1; 1JHU Cryptococcus neoformans. A. Yoneda, T. L. Sung, M. Yeo, H. Oh, C. Teodorof, J. Bae, W. ICMIC Program - Radiology Department, Johns Doering; Molecular Microbiology, Washington Song; Life Science, Gwangju Institute of Science Hopkins University School of Medicine, Baltimore, University in St. Louis School of Medicine, St. and Technology (GIST), Gwangju, Republic of MD, 2Institute of Molecular Cardiobiology, Johns Louis, MO Korea Hopkins University School of Medicine, Baltimore, 1801 B147 At the Invisible Rim: A 1782 B128 V-Src Suppresses the MD Biophysicist's View of the Pericellular Coat. J. 1 2 1 2 Expression but Stimulates Tyrosine 1792 B138 Fibronectin Regulates the E. Curtis, H. Boehm, L. Taing, T. A. Mundinger, 1 2 1 Phosphorylation of Vinexin. T. Umemoto, K. Assembly of Latent TGF-␤ Binding Protein -4 V. Kodali, J. P. Spatz ; School of Physics/Petit Tanaka, T. Inomoto, M. Mitsushima, K. Ueda, N. (LTBP-4) Into the Extracellular Matrix. A. K. Institute of Bioengineering and Bioscience, Georgia 2 Kioka; Division of Applied Life Sciences, Graduate Kantola, J. Keski-Oja, K. Koli; Departments of Institute of Technology, Atlanta, GA, Department School of Agriculture, Kyoto University, Kyoto, Virology and Pathology, University of Helsinki, of New Materials and Biosystems, Max Planck Japan Helsinki, Finland Institute for Metals Research, Stuttgart, Germany 1783 B129 The Effects of TGF-␤1, ALK 1793 B139 Multiple ␤1 Integrin Cytoplasmic Inhibitor, and Vanadate on Vinculin Expression Domain Single Site Mutations Modulate Integrins in Human Fibroblasts and Myofibroblasts. G. Fibronectin Fibrillogenesis and Integrin Kamel, H. Ehrlich; Division Plastic Surgery, MS Function. J. A. Green,1 A. Berrier,2,1 R. Pankov,3,1 1802 B148 Tumor Cell Migration through Hershey Penn State College of Medicine, Hershey, K. M. Yamada1; 1Laboratory of Cell and Connective Tissue in 3-D. C. T. Mierke, P. PA Developmental Biology, NIDCR, National Institutes Kollmannsberger, C. Raupach, D. Paranhos- 2 Zitterbart, T. Koch, W. H. Goldmann, B. Fabry; 1784 B130 A Tunable Vinculin Expression of Health, Bethesda, MD, Katrina Visiting Faculty Medical Physics and Technology, University of System Applied to Cell Adhesion Studies. D. W. Program, NCMHD, National Institutes of Health, 3 Erlangen–Nuremberg, Erlangen, Germany Dumbauld,1 C. A. Gersbach,2 S. W. Craig,3 A. J. Bethesda, MD, Department of Cytology, Faculty of Biology, Sofia University, Sofia, Bulgaria Garcia1; 1Woodruff School of Mechanical 1803 B149 Force-dependent Breast Engineering, Petit Institute for Bioengineering and 1794 B140 The Enigma of Fibronectin Metastasis and Integrin Specificity. C. G. Bioscience, Georgia Institute of Technology, Matrix Assembly: Deciphering the Self- Kaiser,1,2 K. Yee,1 G. Rozenberg,3 M. Dembo,4 D. 2 Atlanta, GA, Department of Molecular Biology, The Association Sites. T. Ohashi, H. P. Erickson; Cell Hammer,1 V. M. Weaver2,5; 1Bioengineering, Scripps Research Institute, La Jolla, CA, Biology, Duke University Medical Center, Durham, University of Pennsylvania, Philadelphia, PA, 3 Department of Biological Chemistry, The Johns NC 2Department of Surgery, University of California, Hopkins School of Medicine, Baltimore, MD San Francisco, San Francisco, CA, 3IME, 1795 B141 Retention of Thrombospondin-1 University of Pennsylvania, Philadelphia, PA, 1785 B131 Nedd4 Regulates Cell Motility in Extracellular Matrix Is Controlled by the 4Bioengineering, Boston University, Boston, MA, through Modulation of Vesicular Trafficking and Conserved TSP C-terminal Region in a F-actin- 5Center for Bioengineering and Tissue Focal Adhesion Targeting of ␤Pix. S. Lee, Y. Na, dependent Process. J. C. Adams,1 N. Regeneration, University of California, San D. Park; School of Biological Science, Seoul Amponsah,1 A. Bentley,1 M. Kvansakul,2 E. Francisco, San Francisco, CA National University, Seoul, Republic of Korea Hohenester2; 1Cell Biology, Cleveland Clinic 2 1804 B150 A Molecular Switch That 1786 B132 Loss of Fibrocystin Leads to Foundation, Cleveland, OH, Cell and Molecular Controls Integrin-dependent Cell Spreading and Focal Adhesion Complex Protein Biology, Biophysics Section, Imperial College Retraction. P. Flevaris, A. Stojanovic, H. Gong, A. Phosphorylation and Functional Abnormalities London, London, United Kingdom Chishti, E. Welch, X. Du; University of Illinois at in Autosomal Recessive Polycystic Kidney Chicago, Chicago, IL Disease (ARPKD) Epithelia. S. Israeli, K. Amsler, P. Wilson; Medicine, Mount Sinai School of Medicine, New York, NY

149 TUESDAY The American Society for Cell Biology 47th Annual Meeting Poster Session 3 B151–B173 December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org

1805 B151 Role of Integrin Cytoplasmic Diseases: Signaling 1820 B166 Rosiglitazone Inhibits Domain In Vivo. J. Ahn,1 S. Batra,2 N. Stephens,1 Transforming Growth Factor-␤1 Mediated Pro- M. Lee1; 1Biology, Baylor University, Waco, TX, fibrotic Signaling in Human Foreskin 1813 B159 Disruption of the Basal Body 2Institute for Biomedical Studies, Baylor University, Fibroblasts via Peroxisome Proliferator- Compromises Proteasomal Function and Waco, TX activated Receptor gamma-dependent Pathway. Perturbs the Intracellular Wnt Response. J. M. M. Kapoor,1 S. Liu,1 L. Kennedy,1 D. Abraham,2 A. Gerdes,1 Y. Liu,1 N. A. Zaghloul,1 C. C. Leitch,1 S. 1806 B152 A Role for Integrin alpha9beta1 Leask1; 1University of Western Ontario, London, S. Lawson,1 M. Kato,2 P. A. Beachy,2 P. L. Beales,3 in the Re-epithelialization Process of Healing ON, Canada, 2Royal Free and University College 1 2 2 G. N. DeMartino,4 S. Fisher,1 J. L. Badano,5 N. Wounds. P. Singh, C. Chen, D. Sheppard, M. A. Medical School, University College London, Royal 3 1 1 Katsanis1,6,2; 1McKusick-Nathans Institute of Stepp, L. Van De Water ; Cell Biology and Free Campus, London, United Kingdom Cancer Research, Albany Medical College, Albany, Genetic Medicine, Johns Hopkins University, 2 NY, 2Lung Biology Center, Department of Medicine, Baltimore, MD, Department of Molecular Biology 1821 B167 An N-terminal Region of the University of California, San Francisco, San and Genetics, Johns Hopkins University, Baltimore, HPS1 Protein Is Required for Interaction with 3 Francisco, CA, 3Department of Anatomy and Cell MD, Molecular Medicine Unit, Inst. Child Health, HPS4 to Form the Biogenesis of Lysosome- Biology, George Washington University Medical University College London, London, United related Organelle Complex 3 (BLOC-3). C. 4 Center, Washington, DC Kingdom, Department of Physiology, University of Carmona,1 J. S. Bonifacino,2 C. L. Cadilla1; Texas Southwestern Medical Center, Dallas, TX, 1Biochemistry, University of Puerto Rico, School of 5 6 1807 B153 Fibronectin Multimeric Ligands Institut Pasteur, Montevideo, Uruguay, Wilmer Medicine, San Juan, PR, 2Cell Biology and Enhance Integrin-mediated Adhesive Force. T. Eye Institute, Johns Hopkins University, Baltimore, Metabolism Branch, National Institute of Child A. Petrie, A. J. Garcia; Woodruff School of MD Health and Human Development, National Mechanical Engineering and Petit Institute for Institutes of Health, Bethesda, MD Bioengineering and Bioscience, Georgia Institute of 1814 B160 Inhibitory ␬B-␣ Is a Direct BMP Technology, Atlanta, GA Target Gene That Mediates Inhibition of NF-␬B 1822 B168 mAKAP Organizes the Signaling by BMP2 and BMP7 and Anti- Degradation and Activation of HIF-1␣. W. Wong, 1808 B154 Temporal and Spatial Catabolic Effects of BMPs. O. Korchynskyi; J. Scott; Vollum Institute/Howard Hughes Medical ␣ ␣ Distribution of 4 Integrin, Phospho- 4 Integrin, Thurston Arthritis Research Center, University of Institute, Oregon Health & Science University, and Paxillin in CHO Cells Ectopically North Carolina–Chapel Hill, Chapel Hill, NC and Portland, OR Expressing ␣4 Integrin under Shear Flow. T. A. Department of Orthopedic Surgery, Virginia Horn,1 L. Rivera Rosado,1 K. Konstantopoulos,2 J. Commonwealth University, Richmond, VA 1823 B169 The NF-kappaB Pathway in Yang1; 1Cell Biology, The Johns Hopkins University Dystrophic (mdx) Skeletal Muscle Produces School of Medicine, Baltimore, MD, 2Chemical and 1815 B161 mTOR Signaling in Polycystic Elevated Active p65 in the Nuclear Biomolecular Engineering, The Johns Hopkins Kidney Disease. M. A. Hallett, R. L. Bacallao, S. Compartment without Altering the Subcellular University, Baltimore, MD J. Atkinson; Medicine, Indiana University, Distribution of the Transcription Factor. G. W. Indianapolis, IN Millman,1 E. C. Turin,2 A. Samadi,3 C. G. Carlson1; 1809 B155 CD81 Is Essential for HSC 1Physiology, A.T. Still University of Health 1,2 3 1816 B162 cAMP-downstream Effectors, Regeneration. K. K. Lin, R. Benabentos, M. A. Sciences, Kirksville, MO, 2Health Science, Truman 2,4,1 1 EPAC and PKA, Are Involved in Hyper- Goodell ; Immunology, Baylor College of State University, Kirksville, MO, 3Biochemistry, A.T. 2 proliferation of Cholangiocytes in the PCK Rat, Medicine, Houston, TX, Stem Cells and Still University of Health Sciences, Kirksville, MO Regenerative Medicine Center, Baylor College of an Animal Model of Autosomal Recessive 1,2 Medicine, Houston, TX, 3Interdepartmental Polycystic Kidney Disease. J. M. Banales, T. V. 1824 B170 Conditional Deletion of Rac1 in 1 1 1 Program in Cell and Molecular Biology, Baylor Masyuk, S. A. Gradilone, A. I. Masyuk, J. F. Fibroblast Delayed Epidermal Wound Healing. 2 1 1 College of Medicine, Houston, TX, 4Pediatrics, Medina, N. F. LaRusso ; Center for Basic S. Liu,1 M. Kapoor,1 M. Glogauer,2 C. P. Denton,3 Baylor College of Medicine, Houston, TX Research in Digestive Disease, Division of S. Chen,1 A. Leask1; 1CIHR Group in Skeletal Gastroenterology and Hepatology, Mayo Clinic Development and Remodeling, Division of Oral ␣ ␤ 2 1810 B156 Direct Thy-1-Integrin v 3 College of Medicine, Rochester, MN, Laboratory of Biology, University of Western Ontario, London, Interaction Mediates Neuron to Astrocyte Molecular Genetics, Division of Gene Therapy and ON, Canada, 2CIHR Group in Matrix Dynamics and 1 1 Communication. L. Leyton, T. Hermosilla, R. Hepatology, University of Navarra School of Dental Research Institute, University of Toronto, 1 1 2 Herrera-Molina, A. Valdivia, S. Nham, P. Medicine, Clínica Universitaria and CIMA, Toronto, ON, Canada, 3The Centre for 3 4 1 Schneider, K. Burridge, A. F. G. Quest ; Pamplona, Spain Rheumatology, Royal Free Campus, University 1 FONDAP Center for Molecular Studies of the Cell, College London, London, United Kingdom Facultad de Medicina, Universidad de Chile, 1817 B163 The Potential Influence of NF- Santiago, Chile, 2Divison of Science Education and kappaB Down Regulation on the Activity of the 1825 B171 Inactivation of Chibby Affects Biology, Kangwon National University, Coonchun PI3/AkT Pathway in Dystrophic (mdx) Skeletal Both Motile and Primary Cilia. V. A. Voronina,1 P. 1 1 1 Kangwon, Republic of Korea, 3Department of Muscle. B. Lee, G. W. Millman, E. C. Turin, A. M. Treuting,2 B. R. Grubb,3 A. M. Hajjar,4 C. 2 1 1 Biochemistry, University of Lausanne, Epalinges, Samadi, C. G. Carlson ; Physiology, A.T. Still Hubbert,1 K. Takemaru,5 R. T. Moon1; Switzerland, 4Department of Cell and University of Health Sciences, Kirksville, MO, 1Pharmacology, University of Washington, Seattle, 2 Developmental Biology, University of North Biochemistry, A.T. Still University of Health WA, 2Comparative Medicine, University of Carolina at Chapel Hill, Chapel Hill, NC Sciences, Kirksville, MO Washington, Seattle, WA, 3Medicine, University of North Carolina, Chapel Hill, NC, 4Immunology, 1818 B164 Induction of FGF Receptor 1 by 1811 B157 Alpha 2 Beta 1 Integrin Induces University of Washington, Seattle, WA, Related Transcription Enhancer Factor in ICAM-1 Expression in Human Mesangial Cells. 5Pharmacology, SUNY, Stony Brook, NY M. Tamura,1 M. Tokunaga,1 N. Kabashima,1 R. Hypoxia via HIF-1␣-independent Pathway. Q. 1 1,2 1 1,2 1 Serino,2 T. Shibata,2 T. Miyamoto,2 M. Miyazaki,2 Y. Song, C. Zhang, I. Lubenec, D. Li, J. Shie, 1826 B172 Age-associated Change of p38 2 1 1 Furuno,2 Y. Tanaka,3 Y. Otsuji2; 1Kidney Center, Y. Tian, J. Li ; Cardiology, Beth Israel Deaconess MAPK Localization in Human Granulosa Cells. 2 University of Occupational and Environmental Medical Center, Boston, MA, Pathophysiology, M. Ito,1 K. Miyado,2 H. Saito,1 Y. Takahashi1; Health, Kitakyushu, Japan, 2Second Department of Harbin Medical University, Harbin, China 1Perinatal Medicine and Maternal Care, National Internal Medicine, University of Occupational and Center for Child Health and Development, Tokyo, 1819 B165 Polycystin-1 Induces Cell Environmental Health, Kitakyushu, Japan, 3First Japan, 2Reproductive Biology and Pathology, Migration by Regulating PI3kinase-dependent Department of Internal Medicine, University of National Center for Child Health and Development, Cytoskeletal Re-arrangements and GSK3␤- Occupational and Environmental Health, Tokyo, Japan dependent Cell-Cell Mechanical Adhesion. M. Kitakyushu, Japan 1 1 1 Boca, L. D'Amato, G. Distefano, R. S. 1827 B173 Inhibition of Transforming 2 3 1 1812 B158 A Novel Cas Family Member, Polishchuk, G. G. Germino, A. Boletta ; Growth Factor (TGF-B) Induced Collagen 1 HEPL Regulates Cell Spreading. M. K. Singh, D. Functional Genomics, Dulbecco Telethon Institute Expression by Nuclear Orphan Receptor Small 2 Dadke, E. Nicolas, I. Serebriiskii, S. Apostolou, S. (DTI), Milano, Italy, Department of Cell Biology Heterodimer Partner (SHP) Is Altered by a Apostolou, A. Canutescu, O. Plotnikova, E. and Oncology, Consorzio "Mario Negri Sud" Santa Smad3 Linker-Region Phosphorylation Mutant 3 Golemis; Basic Sciences, Fox Chase Cancer Maria Imbaro, Chieti, Italy, The Johns Hopkins Smad3EPSM in Renal Cells. R. D. Smith, T. Center, Philadelphia, PA University School of Medicine, Baltimore, MD Hayashida, H. Schnaper; Pediatrics, Northwestern University, Chicago, IL

150 The American Society for Cell Biology 47th Annual Meeting TUESDAY December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org Poster Session 3 B174–B199

1828 B174 Assessment of the Contribution 1837 B183 Cardiac-specific Myosin Light 1845 B191 Carbon Monoxide Repression of of Insulin-like Growth Factor I Receptor 3174 G Chain Kinase (MLCK), a Third Member of MLCK Interleukin-1beta Transcription in THP-1 Cells. → A Polymorphism to the Progression of Family, Potentiates Sarcomere Formation and M. Chhikara, S. Wang, R. L. Danner; Clinical Advanced Retinopathy of Prematurity. B. S. Cardiac Contraction. H. Kasahara,1 J. Y. Chan,1 Center/Critical Care Medicine Department, National Shastry; Biological Sciences, Oakland University, M. Takeda,1 L. E. Briggs,1 M. L. Graham,1 J. T. Institutes of Health, Bethesda, MD Rochester, MI Lu,2 N. Horikoshi,3 E. O. Weinberg,4 H. Aoki,5 K. R. ␬ Chien6; 1Physiology and Functional Genomics, 1846 B192 Differential Activation of NF- B University of Florida, Gainesville, FL, 2Cardiology in CCR1-mediated Signaling. K. Sook Hee, S. Diseases: Vascular Division, University of California, San Diego, La Jang, Y. Kim, J. Ko; School of Life Sciences and Jolla, CA, 3Radiation Oncology, Washington Biotechnology, Korea University, Seoul, Republic of 1829 B175 Bone Marrow-derived University School of Medicine, St. Louis, MO, Korea Mesenchymal Stem Cells Enhance Corneal 4Cardiovascular Research Center, Boston 1847 B193 The Anti-Inflammatory Effect of Wound Healing through IL-10-dependent University, Boston, MA, 5Molecular Cardiovascular Annexin-1 in the Rat Basophilic Leukemia Mechanism in a Rat Chemical Burn Model. M. Biology, Yamaguchi University School of Medicine, (RBL-2H3) Cell Activation. J. Kwon,1 J. Kim,2 I. Kim, J. Oh, H. Lee, M. Shin, J. Lee, W. Wee; 6Cardiovascular Research Center, Ube, Japan, Kim1; 1The Laboratory of Cellular and Molecular Department of Ophthalmology, Seoul National Massachusetts General Hospital, Boston, MA Biochemistry, School of Life Sciences and University Hospital, Seoul, Republic of Korea 1838 B184 A Potential New Cell Source for Biotechnology, Korea University, Seoul, Republic of 2 1830 B176 Endothelial Expression of Vasculogenesis in Ischemia, CD31-;CD146- Side Korea, Inflammatory Signaling Laboratory, School Polycystins. C. Iomini, T. Tchelebi, L. Battini, L. Population Cells from Dental Pulp. M. of Life Sciences and Biotechnology, Korea Gusella, P. Wilson; Medicine, Mount Sinai School Nakashima,1 K. Iohara,1 L. Zheng,1 H. Wake,2 M. University, Seoul, Republic of Korea of Medicine, New York, NY 3 H. Wakita,4 J. Nabekura,2 H. Nakamura,5 T. Ito, 1848 B194 Phagocytosis of Amorphous Into,1 K. Matsushita1; 1Laboratory of Oral Disease and Crystalline Silica Induces Cell Death. L. M. 1831 B177 Co-culture of Retinal and Research, National Institute for Longevity Sciences, Costantini, D. A. Knecht; Molecular and Cell Endothelial Cells Modulates Several Genes and Obu, Japan, 2Department of Developmental Biology, University of Connecticut, Storrs, CT Transcription Factors Critical to Retinal Physiology, National Institute for Physiological Neovascularization. R. Kumar,1 K. Dutt,2 S. Sciences, Okazaki, Japan, 3Department of 1849 B195 Membrane Ruffles Facilitate Harris-Hooker,2 G. Sanford1; 1Microbiology, Developmental Anatomy and Regenerative Binding of C3bi-opsonized Particles. P. C. Patel, Biochemistry and Immunology, Morehouse School Medicine, National Defense Medical College, R. E. Harrison; Department of Biological Sciences, of Medicine, Atlanta, GA, 2Department of Tokorozawa, Japan, 4Department of Vascular University of Toronto at Scarborough, Toronto, ON, Pathology, Morehouse School of Medicine, Atlanta, Dementia Research, National Institute for Longevity Canada GA Sciences, Obu, Japan, 5Department of 1850 B196 Prevention of LPS-induce/TLR- 1832 B178 Preconditioning with 60 Hz Endodontology, School of Dentistry, Aichigakuin dependent Activation of Astrocytes and Magnetic Fields Enhances Survival in H9c2 University, Nagoya, Japan Endothelial Cells by Extracellular Gelsolin. R. Cardiomyocytes and Elevates Levels of Hsp32 Bucki,1 F. J. Byfield,1 P. C. Georges,1 A. and the Anti-Apoptotic Protein Bcl-2. M. V. Cell Biology of the Immune System II Kulakowska,2 A. Sadzynski,3 P. A. Janmey1; Kurian,1 L. R. Hamilton,1 P. M. Mehl,2 J. K. 1Physiology, University of Pennsylvania, Keeven,2 A. L. Di Carlo,1 J. M. Mullins1; Philadelphia, PA, 2Department of Neurology, 1Department of Biology, The Catholic University of 1839 B185 p47phox-deficient Dendritic Cells Enhance Antigen-specific T Cell Medical University of Bialystok, Bialystok, Poland, America, Washington, DC, 2Vitreous State ␥ 3Suwalki's District Hospital, Suwalki, Poland Laboratory, The Catholic University of America, Proliferation and IFN- Secretion. M. A. Washington, DC Jendrysik, N. Zhu, A. Wood, C. Changpriroa, S. Jackson; NIAID, NIH, Bethesda, MD 1851 B197 Deficiency of CIZ Suppresses Serum-induced Arthritis. T. Nakamoto,1,2 F. 1833 B179 The Role of Annexins in Mizoguchi,1,2,3 Y. Izu,3 T. Hayata,3 Y. Ezura,3 N. Interaction of (a) with Endothelial 1840 B186 Correlation of Active LFA-1 Miyasaka,1,2 M. Noda3,2; 1Medicine and Cells. Y. Fu, J. H. Wu; Microbiology and Integrins and Local Stiffness in Migrating T 1 N. A. Morin,2 G. Li,1 J. S. Rheumatology, Tokyo Medical and Dental Immunology, Chang Gung University, Tao Yuan, Cells. P. W. Oakes, Reichner,3 M. Kim,4 J. X. Tang1; 1Physics University, Tokyo, Japan, 221st Century Center of Taiwan Department, Brown University, Providence, RI, Excellence (COE) Program for Frontier Research 1834 B180 TIMAP Is a Positive Regulator of 2Surgery, Rhode Island Hospital, Providence, RI, on Molecular Destruction and, Tokyo Medical and Pulmonary Endothelial Barrier Function. C. 3Surgery, Brown Medical School, Providence, RI, Dental University, Tokyo, Japan, 3Department of Csortos,1 I. Czikora,1 D. Adyshev,2 G. Olah,2 A. D. 4Microbiology & Immunology, University of Molecular Pharmacology, Medical Research Verin3; 1Research Center for Molecular Medicine, Rochester Medical Center, Rochester, NY Institute, Tokyo Medical and Dental University, University of Debrecen, Debrecen, Hungary, Tokyo, Japan 1841 B187 Increased Expression of CD14 2Department of Medicine, The University of in Macrophages After Inhibition of the 1852 B198 A New Dimmer Peptide That Chicago, Chicago, IL, 3Vascular Biology Center, Cholesterol Biosynthetic Pathway by Exhibits Anti-Oxidant and Whitening Properties. Medical College of Georgia, Augusta, GA Lovastatin. T. A. Frey,1 A. DeMaio2; 1Physiology, E. Bauza, C. Dal Farra, N. Domloge; Skin 1835 B181 VIP Gene Deletion Triggers Johns Hopkins University, Baltimore, MD, 2Surgery, Research Center, Vincience, ISP, Sophia Antipolis, Gene Expression Changes Promoting University of California, San Diego, San Diego, CA France Pulmonary Vascular Remodeling. S. I. Said,1 S. 1842 B188 CFTR Mediation of Phagosomal 1853 B199 Production of Interleukin-5, A. Hamidi,1 S. Prabhakar2; 1Pulmonary & Critical Interleukin-13, and Interferon-␥ in Stimulated Care Medicine, State University of New York, Stony Acidification in Murine Macrophages Studied TM E. coli Bioparticles. D. Beacham,1 Cd4+ and Cd8+ T Cells from Children with Brook & Department of Veterans Affairs Medical with pHrodo L. Deriy,2 D. Nelson,2 J. Dzubay,1 V. Martin,1 A. Wheezing. H. Kim,1 J. Yoon,2 J. Lee2; 1Pediatrics, Center, New York, NY, 2Superarray Biosciences, Rukavishnikov,1 I. Johnson,1 K. Gee1; 1Molecular Holy Family Hospital, the Catholic University of Frederick, MD Probes Invitrogen, Eugene, OR, 2University of Korea, Pucheon-Si, Republic of Korea, 2Pediatrics, 1836 B182 WITHDRAWN Chicago, Chicago, IL the Catholic University of Korea, Seoul, Republic of Korea 1843 B189 Regulation of Interleukin-1 Cytokine Responses in Intestinal Epithelial Cells by Rho Kinase. B. J. Rafferty, D. W. McGee; Biological Sciences, SUNY Binghamton, Binghamton, NY

1844 B190 Intracellular Trafficking of IL-3␤ and IL-4 in RBL-2H3 Mast Cells. N. L. Smith, D. Holowka, B. Baird; Chemistry and Chemical Biology, Cornell University, Ithaca, NY

151 TUESDAY The American Society for Cell Biology 47th Annual Meeting Poster Session 3 B200–B224 December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org

Cancer III 1863 B209 Transcriptional Regulation of 1871 B217 Transient Infection with a Inhibitor of Apoptosis Proteins by Ionizing Common Enteric Pathogen Increases Colon Radiation and Camptothecin through Two Cancer Invasion via ROCK Signaling in an In 1854 B200 Targeting of Thyroid Hormone Distinct Mechanisms in Human Leukemic Cells. Vitro Model. S. C. Glover,1 M. Bulic,1 R. Receptor Variants to Aggresomes. A. M. K. Park,1,2,3 H. Lee,1 M. Won,1 H. Byun,1 B. Choi,1 Vishnubhotla,1 J. Huq,1 R. Mecum,1 M. Gupte,1 S. Brunner,1 C. D. Connor,2 P. A. Belt,2 C. Bondzi,2 L. Y. Kim,1 K. Yang,1 S. Shin,1 L. Piao,1 E. Shin,1 Y. Sun,2 M. Cho1; 1Medicine, University of Illinois at A. Allison1; 1Biology, College of William and Mary, Li,1 J. Hong,1 J. Seok,1 J. Park,1,4,5 G. Hur1,2,3; Chicago, Chicago, IL, 2Bioengineering, University Williamsburg, VA, 2Biological Sciences, Hampton 1Pharmacology, Chungnam National University, of Illinois at Chicago, Chicago, IL University, Hampton, VA Daejeon, Republic of Korea, 2Infection Signaling 1872 B218 ICAM-3 Up-Regulates the 1855 B201 VEGF Induces Autotaxin Network Research Center, Daejeon, Republic of 3 Invasiveness of the Human Non-Small Cell Expression in Ovarian Cancer and Endothelial Korea, Daejeon Regional Cancer Center, Daejeon, Republic of Korea, 4Cancer Research Institute, Lung Cancer Cell through the Activation of Cells. M. M. Ptaszynska, M. L. Pendrak, D. D. 1 2 5 MMP-2 and PI3K/Akt Pathway. S. Park, Y. Yoo, Roberts; Pathology, National Cancer Institute, Daejeon, Republic of Korea, Research Institute for H. Um,1 S. Hong,1 J. Park1; 1Laboratory of Bethesda, MD Medical Sciences, Daejeon, Republic of Korea Radiation Tumor Physiology, Korea Institute of 1856 B202 The Extracellular Domain of 1864 B210 Activation of PKC and NF-␬B Radiological and Medical Sciences, Seoul, PTK7 Inhibits the VEGF-induced Migration of Contribute to Cell Killing by Inhibitors of Fatty Republic of Korea, 2Graduate School of Medicine, HUVECs. W. Shin, Y. Maeng, J. Jung, J. Min, Y. Acid Synthase. C. R. M. Lemmon,1 J. Woo,2 E. Korea University, Seoul, Republic of Korea Kwon, S. Lee; Department of Biochemistry, College Tully,2 F. Kuhajda,3 E. Gabrielson3; 1Pathology, 1873 B219 The Role of Abl Family Kinase- of Science, Yonsei University, Seoul, Republic of Johns Hopkins University School of Medicine, Baltimore, MD, 2Oncology, Johns Hopkins mediated Phosphorylation of Cortactin in Korea 1,2 University School of Medicine, Baltimore, MD, Breast Cancer Invasion. C. C. Mader, K. 3 3 2,4,5 1 1857 B203 Effects of Estrogen Stimulation 3Oncology, Pathology, Johns Hopkins University Machida, B. J. Mayer, A. J. Koleske ; Cell of ␤-adrenergic Receptors in Estrogen School of Medicine, Baltimore, MD Biology, Yale University, New Haven, CT, Responsive and Non-Responsive Breast 2Molecular Biophysics and Biochemistry, Yale Cancer. M. Hance, H. K. Plummer; Pathobiology, 1865 B211 Rearranged in Transformation/ University, New Haven, CT, 3Genetics and University of Tennessee, Knoxville, TN Papillary Thyroid Carcinoma (RET/PTC)-induced Developmental Biology, University of Connecticut Signal Transducer and Activator 3 (Stat3) Health Center, Farmington, CT, 4Neurobiology, Yale 1858 B204 ErbB-2 Signaling Is involved in Activation Is Up-Regulated by Phospholipase D University, New Haven, CT, 5Interdepartmental Matriptase Zymogen Activation in Human (PLD) in Thyroid Cancer Cells. Y. Kim,1,2,3 H. Neuroscience Program, Yale University, New Prostate Cancer Cells. S. Wu,1 Y. Tu,1 Y. Cheng,1 Byun,1 M. Won,1 K. Park,1 B. Choi,1 H. Lee,1 J. Haven, CT C. Lin,2 M. Lee1; 1Department of Biochemistry and Hong,1 J. Park,1,4,5 J. Seok,1 G. Hur1,2,3; 1College Molecular Biology, College of Medicine, National of Medicine, Chungnam National University, 1874 B220 ARF6 Regulates Invasive and 1 Taiwan University, Taipei, Taiwan, 2Department of Daejeon, Republic of Korea, 2Infection Signaling Metastatic Properties In Vivo. H. Hoover, V. 1 2 2 1 Biochemistry and Molecular Biology, University of Network Research Center, Daejeon, Republic of Chari, M. Suckow, V. Schroeder, J. Schorey, C. 1 1 Maryland School of Medicine, Baltimore, MD Korea, 3Daejeon Regional Cancer Center, Daejeon, D'Souza-Schorey ; Biological Sciences, University 2 Republic of Korea, 4Cancer Research Institute, of Notre Dame, Notre Dame, IN, Freimann Life 1859 B205 Upregulation of bcl-xl in Daejeon, Republic of Korea, 5Research Institute for Science Center, University of Notre Dame, Notre Cigarette Smoke Condensate-treated Medical Sciences, Daejeon, Republic of Korea Dame, IN Spontaneously Immortalized Human Breast Epithelial Cells. S. K. Connors,1 R. Balusu,2 C. N. 1866 B212 Involvement of Human GAPDH 1875 B221 Snail's Pace in Ovarian 1 2 1 Kundu,3 A. S. Jaiswal,1 S. Narayan1; 1Department in hTAF 68-TEC-mediated Transcription as a Carcinoma. S. Elloul, B. Davidson, R. Reich ; II 1 of Anatomy and Cell Biology, UF Shands Cancer Coactivator. S. Kim, J. Lee, J. Kim; Life Science, Pharmacology and Experimental Therapeutics, Center, University of Florida, Gainesville, FL, Sogang University, Seoul, Republic of Korea School of Pharmacy, Faculty of Medicine, The 2Department of Biochemistry, University of Florida, Hebrew University of Jerusalem, Jerusalem, Israel, Gainesville, FL, 3Department of Cancer Biology, 1867 B213 De Novo Protein Synthesis Is 2Pathology, Radiumhospitalet-Rikshospitalet Lerner Research Institute, Cleveland Clinic Required for the Proteasome Inhibition-induced Medical Center, University of Oslo, Oslo, Norway Foundation, Cleveland, OH Nuclear Translocation of I␬B␣ in Metastatic Prostate Cancer Cells. H. T. Vu, A. P. Juvekar, C. 1876 B222 Chaperone-dependent 1860 B206 A20 Downregulates ASK1- C. Ghosh, S. Ramaswami, I. Vancurova; Maturation of the Androgen Receptor Complex mediated JNK Signaling Pathway Upon TNF Department of Biology, St. John's University, in Androgen-independent Prostate Cancer. L. 1 1 2 1 3 Treatment. M. Won,1,2,3 H. Byun,1 K. Park,1 Y. Queens, NY Ni, A. Spencer, D. Gioeli, C. Yang, D. Toft, B. Kim,1 B. Choil,1 H. Lee,1 K. Yang,1 S. Shin,1 L. Paschal1; 1Center for Cell Signaling, University of Piao,1 E. Shin,1 J. Hong,1 J. Park,1,4,5 J. Seok,1 G. 1868 B214 Calcineurin-mediated Virginia, Charlottesville, VA, 2Department of Hur1,2,3; 1Department of Pharmacology, Chungnam Dephosphorylation of c-Jun Ser-243 Is Required Microbiology, University of Virginia, Charlottesville, National University, College of Medicine, Daejeon, for c-Jun Protein Stability and Cell VA, 3Department of Biochemistry and Molecular Republic of Korea, 2Infection Signaling Network Transformation. C. Huang1,2; 1National Cheng Biology, Mayo Clinic, Rochester, MN Research Center, Daejeon, Republic of Korea, Kung University, Tainan, Taiwan, 2Institute of Basic 3 Medical Sciences, Tainan, Taiwan Daejeon Regional Cancer Center, Daejeon, Neuronal Diseases II Republic of Korea, 4Cancer Research Institute, 1869 B215 Epidermal Growth Factor Daejeon, Republic of Korea, 5Research Institute for Induces Epithelial-Mesenchymal Transition in Medical Sciences, Daejeon, Republic of Korea 1877 B223 Early Developmental Changes in Cervical Cancer Cells That Is Modulated by CLN8-deficient Mice. M. Kuronen,1,2 T. 1861 B207 CRMP-1 Sensitizes Cells to alpha5 beta1 Integrin Signaling. M. Lee,1 M. Joensuu,1,2 A. Lehesjoki,1,2 O. Kopra1,2; TNF␣-induced Cell Death by Suppressing NF- Shen2; 1Department of Basic Medical Sciences, 1Neuroscience Center, University of Helsinki, ␬B Activation. C. Wang, P. Yang, H. Shih; Institute National Cheng Kung University, Tainan, Taiwan, Helsinki, Finland, 2Folkhalsan Institute of Genetics, of Biomedical Sciences, Academia Sinica, Taipei, 2Department of Pharmacology, National Cheng Helsinki, Finland Taiwan Kung University, Tainan, Taiwan 1878 B224 Mesenchymal Stem Cells 1862 B208 Nuclear Translocation of I␬B␣ 1870 B216 Interaction of Rac1b, a Tumor- Promote Functional Synaptic Transmission after Induces NF␬B Inhibition and Apoptosis in associated Isoform of Rac1, with p120 Catenin Transplantation into Mice with Human Cutaneous T-Cell Lymphoma. A. P. Regulates Induction of Epithelial-Mesenchymal Neurodegeneration. J. Bae,1 H. Jin2; 1Department Juvekar, H. T. Vu, C. C. Ghosh, S. Ramaswami, I. Transition. L. Orlichenko, R. Geyer, P. of Physiology, College of Medicine, Kyungpook Vancurova; Biology, St. John's University, Queens, Anastasiadis, D. Radisky; Cancer Cell Biology, National University, Daegu, Republic of Korea, NY Mayo Clinic, Jacksonville, FL 2College of Veterinary Medicine, Kyungpook National University, Daegu, Republic of Korea

152 The American Society for Cell Biology 47th Annual Meeting TUESDAY December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org Poster Session 3 B225–B253

1879 B225 Role of CSTB in Neuronal 1889 B235 Notch1 Intracellular Domain 1898 B244 The Mitochondrial DNA Mutation Survival: Implications to Disease Mechanisms Suppresses APP Intracellular Domain-Tip60- Is Associated with Abnormal of Long-Term in Progressive Myoclonus Epilepsy. S. S. Fe65 Complex-mediated Signaling through Memory in Mice. D. Tanaka,1 A. Kasahara,1,2 K. Tegelberg, M. Lehtinen, T. Joensuu, O. Kopra, A. Physical Interaction. E. Ann, M. Kim, J. Mo, K. Takao,3,4 T. Miyakawa,3,4 K. Nakada,1,2 J. Lehesjoki; Folkählsan Institute of Genetics and Lee, H. Park; School of Biological Sciences and Hayashi1; 1Graduate School of Life and Neuroscience Center, University of Helsinki, Technology, Chonnam National University, Environmental Sciences, University of Tsukuba, Helsinki, Finland Gwangju, Republic of Korea Tsukuba, Japan, 2Center for Tsukuba Advanced Research Alliance, University of Tsukuba, Tsukuba, 1880 B226 Retrograde Transport of NGF 1890 B236 Mitochondrial Respiration Japan, 3Frontier Technology Center, Graduate Containing Signaling Endosome Is Deficiencies Alter Social Behavior and Spatial School of Medicine, Kyoto University, Kyoto, Japan, 1,2 1,2 Compromised in a Down Syndrome Mouse Memory in Mice. A. Kasahara, K. Nakada, A. 4Division of Systems Medicine, Institute for 1 2 3 1 1 3,4 3,4 1 Model. K. Zhan, B. Cui, N. Jeon, W. C. Mobley ; Sato, K. Takao, T. Miyakawa, J. Hayashi ; Comprehensive Medical Science, Fujita Health 1 1 Neurology & Neurological Sciences, Stanford Graduate School of Life and Environmental University, Toyoake, Japan University, Stanford, CA, 2Chemistry, Stanford Sciences, University of Tsukuba, Tsukuba, Japan, University, Stanford, CA, 3Biomedical Engineering, 2Center for Tsukuba Advanced Research Alliance, 1899 B245 siRNA Mediated Allele Specific University of California at Irvine, Irvine, CA University of Tsukuba, Tsukuba, Japan, 3Frontier Selective Silencing of a Dominant Negative Technology Center, Graduate School of Medicine, COL6A3 Mutation Causing UCMD. Y. Zou, C. G. 1881 B227 Vitamin D and Estrogen Interact Kyoto University, Kyoto, Japan, 4Division of Bonnemann; Children's Hospital of Philadelphia, to Regulate Neuritogenesis in Dorsal Root Systems Medicine, Institute for Comprehensive Philadelphia, PA Ganglion Neurons. S. E. Tague, P. G. Smith; Medical Science, Fujita Health University, Toyoake, Molecular & Integrative Physiology, University of Japan Kansas Medical Center, Kansas City, KS Endothelial Cells 1891 B237 Evaluating the Role of the Multi- 1882 B228 Mutant Huntingtin Induced Vesicular Body/Vacuole Pathway in the 1900 B247 The Enhancing Effect of Hp on Transfected PC12 Cell Death by Overflow of Regulation of ␣-Synuclein Aggregation and Endothelial Progenitor Cell Differentiation and Cholesterol. S. Xu,1 C. T. McMurray2; Toxicity in Budding Yeast. A. E. Ayala, M. Neovascularization. S. Park,1 J. Choi,2 M. Oh,1 N. 1Neuroscience, University of Minnesota, Vahedi, J. Price; Biology, Lake Forest College, Kim,1 J. Shin,3 I. Kim1; 1Natural Sciences, The Minneapolis, MN, 2Pharmacology, Mayo Clinic, Lake Forest, IL Catholic University of Korea, Seoul, Republic of Rochester, MN Korea, 2Ophtalmology and Visual Science, The 1892 B238 Evaluation of E46K & A76E ␣- Catholic University of Korea, Seoul, Republic of 1883 B229 Involvement of the Synuclein Aggregation and Toxicity in Budding Korea, 3Obstetrics & Gynecology, Kangnam St. Prostaglandin E2 Receptors, EP2 and EP4, in the & Fission Yeasts. S. Valtierra, M. White, M. ␤ Mary's Hospital, Seoul, Republic of Korea Production of Amyloid- Peptides Both In Vitro Zorniak, M. Fiske, S. DebBurman; Biology, Lake and In Vivo. T. Hoshino,1 T. Nakaya,2 Y. Forest College, Lake Forest, IL 1901 B248 Dynamic p190 RhoGAP Activity Sugimoto,3 W. Araki,4 M. Narita,5 S. Narumiya,6 T. in Shear Stress Stimulated Endothelial Cells: Suzuki,2 T. Mizushima1; 1Graduate School of 1893 B239 Nitration of Tau at Tyrosine 18: Structural and Biochemical Measurements. R. Medical and Pharmaceutical Sciences, Kumamoto A Possible Link between Astrocyte Activation E. Mott, B. P. Helmke; Biomedical Engineering, University, Kumamoto, Japan, 2Graduate School of and Tau Nitration in Alzheimer's Disease. J. F. University of Virginia, Charlottesville, VA Pharmaceutical Sciences, Hokkaido University, Reyes, M. R. Reynolds, H. M. Peleg, Y. Fu, A. Sapporo, Japan, 3Graduate School of Guillozet-Bongaarts, R. W. Berry, L. I. Binder; Cell 1902 B249 Angiogenesis Inhibition by Pharmaceutical Sciences, Kyoto University, Kyoto, and Molecular Biology, Northwestern University, Semaphorin 3E. A. Sakurai, J. Gavard, J. R. Japan, 4National Institute of Neuroscience, Kodaira, Chicago, IL Basile, Y. Annas-Linhares, J. Gutkind; OPCB, Japan, 5Minase Research Institute, Ono National Institute of Dental and Craniofacial 6 1894 B240 Evaluating alpha-Synuclein Pharmaceutical Co., LTD, Osaka, Japan, Faculty Research, Bethesda, MD of Medicine, Kyoto University, Kyoto, Japan Concentration Threshold and Composition to Induce Aggregation, Membrane 1903 B250 The Role of MEOX Genes in the 1884 B230 Cell Membrane-selective A␤ Localization, and Toxicity in Yeast. L. Kukreja, S. Regulation of Vascular Cell Death. J. M. Binding Is Susceptible to Membrane Valtierra, S. Debburman; Biology, Lake Forest Douville,1,2 J. T. Wigle1,2; 1Institute of Cholesterol Levels. O. Simakova, N. J. Arispe; College, Lake Forest, IL Cardiovascular Sciences, St. Boniface General Anatomy, Physiology and Genetics, Uniformed Hospital Research Centre, Winnipeg, MB, Canada, 1895 B241 Ubiquitination of ␣-synuclein by Services University of the Health Sciences, 2Department of Biochemistry and Medical Genetics, Siah-1 Promotes Inclusion Formation and Bethesda, MD University of Manitoba, Winnipeg, MB, Canada Apoptotic Cell Death. J. T. Lee, L. Chin, L. Li; 1885 B231 Secreted Amyloid Precursor School of Medicine, Emory University, Atlanta, GA 1904 B251 Metallothionein and Zinc Protein Lacking A␤ Sequence Induces Signaling during Hypoxia Induced Contraction 1 1896 B242 Characterization of the Protease Apoptosis of Neurons. W. C. Wallace, J. W. of Isolated Rat Pulmonary Microvascular 2 2 2 1 Activity of Parkinson’s Disease Protein DJ-1 Kusiak, M. S. Wallace, J. Luo ; Science, Endothelial Cells (RPMVECs). P. J. Bernal,1 S. and Its Activation Mechanism. J. Chen, L. Li, L. Georgetown Day School, Washington, DC, Watkins,1 C. M. St Croix2; 1Cell Biology and 2 Chin; Pharmacology, Emory University, Atlanta, GA National Institute on Aging, Laboratory of Cellular Physiology, University of Pittsburgh, Pittsburgh, PA, and Molecular Biology, Baltimore, MD 2 1897 B243 Alterations of Cholesterol and Environmental and Occupational Health, University GM1 Ganglioside in Membrane Rafts Isolated of Pittsburgh, Pittsburgh, PA 1886 B232 GM1 Enrichment of Cell from Murine Niemann-Pick Disease Type C Membranes Facilitates A␤ Ion Channel 1905 B252 14-3-3 Proteins in the Trabecular Brain. J. Li, E. L. Hertzberg, K. Dobrenis, S. Formation. J. C. Diaz, N. J. Arispe; Anatomy, Meshwork. H. Hessle; Opthalmology Research, Walkley; Neuroscience, Albert Einstein College of Physiology and Genetics, Uniformed Services Casey Eye Institute/Oregon Health and Science Medicine, Bronx, NY University of the Health Sciences, Bethesda, MD University, Portland, OR

1887 B233 Expression of Human G59S 1906 B253 NFATc1 and Pulmonary p150Glued in Mice Leads to Motor Neuron Lymphatic Development. R. M. Kulkarni,1,2 J. M. Degeneration Independent of Deficits in Axonal Greenberg,1,2 A. L. Akeson1,2; 1Pulmonary Biology, Transport. E. S. Chevalier-Larsen, K. E. Wallace, Cincinnati Childrens Hospital Research Foundation, E. L. F. Holzbaur; Physiology, University of Cincinnati, OH, 2Cell and Cancer Biology, Pennsylvania, Philadelphia, PA University of Cincinnati, Cincinnati, OH 1888 B234 Effects of DYT1 Mutation on Association between TorsinA and Novel Protein Printor. L. M. Giles, L. Li, L. Chin; Department of Pharmacology, Emory University School of Medicine, Atlanta, GA

153 TUESDAY The American Society for Cell Biology 47th Annual Meeting Poster Session 3 B254–B285 December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org

1907 B254 Expression of Indoleamine 2,3- 1917 B264 Protein Elution and 3D 1928 B275 The Effects of Pathogenic Dioxigenase by Vascular Endothelial Cells at Westerns: Polyacrylamide Gels as Preparative Mutations on Polycystin-1 Mechanical the Human Feto-Maternal Interface. A. Blaschitz,1 Tools. G. R. Green, D. P. Do; Pharmaceutical Properties. L. Ma,1 T. Garcia,2 J. Wang,1 A. F. G. Dohr,1 O. Takikawa,2 P. Sedlmayr1; 1Institute of Sciences, Mercer University, Atlanta, GA Oberhauser1; 1Department of Neuroscience and Cell Biology, Histology and Embryology, Medical Cell Biology, University of Texas Medical Branch, University of Graz, Center of Molecular Medicine, 1918 B265 Rapid Detection of His-tagged Galveston, TX, 2Department of Biochemistry and Graz, Austria, 2National Institute of Longevity Proteins on Western Blots. J. Dubendorff, M. Molecular Biology, University of Texas Medical Science, National Center for Geriatrics and Cruz, C. Gonzalez, J. Hainfeld, W. Liu; Branch, Galveston, TX Gerontology, Obu City, Japan Nanoprobes, Incorporated, Yaphank, NY 1929 B276 Study of Dynamics of FtsZ and 1908 B255 Intersectin-1s Regulates 1919 B266 Purification and Analysis of Z-ring Structure of E. coli Cells. L. Niu; Endothelial Permeability by Coordinating the GST-tagged Proteins Using an Automated Department of Genetics & Developmental Biology, Cross-talk between Transcellular and Protein Purification System. M. Urban, E. Larson, University of Connecticut Health Center, Paracellular Pathways. S. A. Predescu, F. L. Usinger, M. Berardini; Bio-Rad Laboratories, Farmington, CT Neamu, D. Predescu, I. Knezevic, A. Malik; Hercules, CA Pharmacology, University of Illinois at Chicago, 1930 B277 Highly Efficient Reverse 1920 B267 Affinity Purification and Chicago, IL Transfection with siRNA in Multiple Wells of Analysis of His-tagged Proteins Using an Microtiter Plates. S. Fujita, E. Ota, M. Miyake, J. 1909 B256 Identification of a Novel Cell Automated Protein Purification System. M. Miyake; RICE, AIST, Japan, Tokyo, Japan Type in the Intestinal Mucosa of Burmese Urban, E. Larson, L. Usinger, S. Petersen; Bio-Rad Pythons. R. K. Pope,1 J. Lignot2; 1Biological Laboratories, Hercules, CA Sciences, Indiana University South Bend, South Imaging Technology 1921 B268 Efficient Preservation and Bend, IN, 2Le Centre d'écologie et Physiologie Purification of Urinary Proteins. M. Abdalla,1 L. Energétiques, Centre National de la Recherche 1931 B278 Integrated Biophotonics Bernard,2 S. Geng,1 M. Jones,3 Y. Haj-Ahmad4; Approach for Quantitative, Multiscale Scientifique, Strasbourg, France 1Centre for Biotechnology, Brock University, St. Biophysics of Biological Systems. Q. Yu,1 M. Catharines, ON, Canada, 2Norgen Biotek, Thorold, Proia,2 A. A. Heikal1; 1Bioengineering, ON, Canada, 3Biochemistry and Biomedical Molecular Biology and Detection Pennsylvania State University, University Park, PA, Sciences, McMaster University, Hamilton, ON, 2Chemistry, Pennsylvania State University, Canada, 4Biological Science, Brock University, St. 1910 B257 Mica and the Origin of Life: University Park, PA Catharines, ON, Canada Cells without Membranes. H. Hansma; BIO DBI, 1932 B279 Optical Lock-in Detection National Science Foundation, Arlington, VA 1922 B269 Concurrent RNA-DNA-Protein Imaging Microscopy Using Synthetic and Isolation from Bodily Fluids Using Silicon 1911 B258 Genetic Analysis of an Enzyme Genetically-encoded Optical Switches. G. Carbide. M. Abdalla,1 B. Lam,2 Y. Haj-Ahmad3; Involved in Nitric Oxide Metabolism. E. V. Marriott,1 S. Mao,1 Y. Yan2; 1Physiology, University 1Centre for Biotechnology, Brock University, St. Hummell, U. Lee, E. Vierling; Biochemistry and of Wisconsin, Madison, WI, 2Otolaryngology, Catharines, ON, Canada, 2Norgen Biotek, Thorold, Molecular Biophysics, University of Arizona, Stanford University, Stanford, CA ON, Canada, 3Biological Science, Brock University, Tucson, AZ St. Catharines, ON, Canada 1933 B280 Effective Cell Identification and 1912 B259 Analysis of Cultivation Methods Segmentation in Fluorescence Microscopy with 1923 B270 Development of a Quick and of Sponge-associated Bacteria from Marine New Fluorescent Whole Cell Stains. S. J. Hong, Sensitive Homologous Recombination Assay. S. Sponge Haliclona sp. M. Lozada,1 D. Sipkema,2 R. N. Ghosh; ThermoFisher Scientific, Rockford, IL Geng,1 B. Lam,2 Y. Haj-Ahmad1; 1Brock University, H. Blanch2; 1Industrial Biotechnology, University of St. Catharines, ON, Canada, 2Norgen Biotek, Puerto Rico, Mayaguez, Mayaguez, Puerto Rico, 1934 B281 Protein Dynamics Studied with Thorold, ON, Canada 2Chemical Engineering, University of California, Self-Labeling Protein Tags. K. Muentener, A. Brecht; Covalys Biosciences AG, Witterswil, Berkeley, Berkeley, CA 1924 B271 Substrate Specificity of Taq Switzerland Polymerase. A. Haj,1 B. Lam,2 Y. Haj-Ahmad1; 1913 B260 Transcriptional Analysis and 1Biological Science, Brock University, St. Functional Characterization of a Gene Pair 1935 B282 An Integrated System for Catharines, ON, Canada, 2Norgen Biotek, Thorold, Encoding Iron Regulated Xenocin and Immunity Correlative Fluorescence and Electron ON, Canada 1 2 Proteins of Xenorhabdus nematophila. J. Microscopy. A. V. Agronskaia, J. A. Valentijn, L. 2 3 Singh,1,2 N. Banerjee,2 R. Bhatnagar1; 1School of F. van Driel, C. T. W. Schneijdenberg, B. M. 1925 B272 The Inhibitors of Polymerase 3 3 Biotechnology, Jawaharlal Nehru University, New 1 Humbel, P. van Bergen en Henegouwen, A. J. Chain Reaction in Biological Culture. L. Zhang, 3 2 1 1 2 Verkleij, A. J. Koster, H. C. Gerritsen ; Molecular Delhi, India, Insect Resistance Group, B. Lam,2 Y. Haj-Ahmad1; 1Biological Science, Biophysics, Utrecht University, Utrecht, The International Centre for Genetic Engineering and Brock University, St Catharines, ON, Canada, Netherlands, 2Molecular Cell Biology, Leiden Biotechnology, New Delhi, India 2Norgen Biotek, Thorold, ON, Canada University Medical Center, Leiden, The 3 1914 B261 A Novel Approach to Modulate 1926 B273 Expression and Purification of Netherlands, Cell Biology, Utrecht University, Kinase Activity in Live Cells: Model Studies AR-LBD for X-Ray Crystallography Study: Side- Utrecht, The Netherlands with Focal Adhesion Kinase (FAK). A. V. Chain Rotamers in DHT Binding Site 1936 B283 Noise-induced Systematic Karginov, J. S. Edwards, K. M. Hahn; Inconsistent with Published Structure. W. Hum,1 Errors in Ratio Imaging: Serious Artifacts and Pharmacology, University of North Carolina, Chapel K. Parris,1 T. Berrodin,2 M. Johnson,1 K. Svenson,1 Correction with Multi-Resolution Denoising. Y. Hill, NC K. Malakian,1 A. Smith,1 E. Kilbourne,2 M. Stahl1; Wang; Physiology, University of Massachusetts 1Chemical & Screening Sciences, Wyeth Research, 1915 B262 Induced Heterodimerization to Medical School, Worcester, MA Cambridge, MA, 2Woman's Health & Quantify NLS- and NES-mediated Nuclear Musculoskeletal Biology, Wyeth Research, Protein Transport in Mammalian Cells. A. Busch, 1937 B284 Sensitive Biosensor for Src Collegeville, PA T. Kiel, S. Huebner; University of Wuerzburg, Activation Based on High Throughput Screening of Engineered Biosensor Scaffolds. Institute for Anatomy and Cell Biology, Wuerzburg, 1927 B274 The Nanomechanics of C. A. Gulyani,1 D. Gremyachinskiy,1 B. J. Dewar,1 L. Germany elegans Giant Protein Kinase Domains. D. N. M. Graves,1 B. K. Kay,2 K. M. Hahn1; Greene,1 T. Garcia,2 G. M. Benian,1 A. F. 1916 B263 Visualization of Protein 1Pharmacology, University of North Carolina, Oberhauser2; 1Pathology, Emory University, Interactions and Post Translational Chapel Hill, NC, 2Biological Sciences, University of Atlanta, GA, 2Neuroscience and Cell Biology, The Modifications Using In Situ Proximity Ligation Illinois, Chicago, IL University of Texas Medical Branch (UTMB), Assay (In Situ PLA). E. Nystrom; Olink, Uppsala, Galveston, TX Sweden 1938 B285 Imaging Axonal Transport with Iron Nanoparticles. C. R. Kyrtsos, K. Huang, S. H. Ehrman, S. B. Shah; Bioengineering, University of Maryland, College Park, MD

154 The American Society for Cell Biology 47th Annual Meeting TUESDAY December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org Poster Session 3 B286–B318

1939 B286 Raster Image Correlation 1950 B297 Novel Nesprin-1 Isoforms 1960 B307 Ultrastructural and Functional Spectroscopy (RICS) and Moment Analysis Localize to the Nucleolus and Disrupt the Analysis of the Nuclear Localization Sequences Reveal In Vivo Oligomerization State for Formation of Cytoplasmic Processing Bodies. on Influenza A Viral Ribonucleoprotein Polarization Protein in Living Yeast. S. E. Smith, J. A. Mellad,1 M. Boem,1 C. Shanahan2; 1NHLBI Complexes. W. W. H. Winco, L. L. Weaver, N. B. Slaughter, J. Huff, W. Wiegraebe, R. Li, J. W. Cardiology Branch, National Institues of Health, Pante; Department of Zoology, University of British Schwartz; Stowers Institute for Medical Research, Bethesda, MD, 2Department of Medicine, University Columbia, Vancouver, BC, Canada Kansas City, MO of Cambridge, Cambridge, United Kingdom 1961 B308 Abstract Withdrawn 1940 B287 Screening for Molecular 1951 B298 Nuclear Membrane Proteins for Interactions via AFRET High-Throughput Assay. Anchoring Telomeres in Fission Yeast. Y. 1962 B309 STRAD Regulates LKB1 C. H. J. Cooper, J. W. Schwartz; Stowers Institute Chikashige,1 C. Tsutsumi,1 M. Yamane,1 K. Localization by Blocking Access to Importin for Medical Research, Kansas City, MO Okamasa,1 T. Kojidani,1,2 T. Haraguchi,1,2 Y. Alpha, and by Association with CRM1 and Hiraoka1,3; 1Kobe Advanced ICT Research Center, Exportin-7. J. Dorfman, I. Macara; Center for Cell 1941 B288 Surface Plasmon Resonance Kobe, Japan, 2CREST/JST, Kobe, Japan, 3Osaka Signaling, University of Virginia, Charlottesville, VA Imaging for Studying Cells and Their University, Graduate School of Frontier Bioscience, Extracellular Environment. A. W. Peterson,1 M. 1963 B310 Differential Localization of Suita, Japan ␣ Halter,1 A. Tona,2 K. Bhadriraju,2 A. L. Plant1; Thyroid Hormone Receptor in Neuronal and 1Biochemical Science Division, National Institute of 1952 B299 Studies of Movement of DNA Non-Neuronal Cell Lines. G. A. Elias, L. A. Standards and Technology, Gaithersburg, MD, Sites in Yeast Nuclei. J. L. Campbell, O. Cohen- Allison; Biology, College of William and Mary, 2SAIC, Gaithersburg, MD Fix; NIDDK, LMCB, NIH, Bethesda, MD Williamsburg, VA

1942 B289 Learnable Tracking for Multiple 1953 B300 Elevated Concentrations of 1964 B311 General Mechanism of Thyroid Moving Subcellular Objects in Time-Lapse Nucleoporin Nup153 Lead to Failure of Hormone Receptor Nuclear Import. V. R. Microscopy Assays. S. V. Alworth, S. Oh, Y. Cytokinesis. B. Fahrenkrog,1 D. K. Shumaker,2 R. Roggero, L. A. Allison; Biology, The College of Cheng, J. S. J. Lee; SVision LLC, Bellevue, WA D. Goldman2; 1M.E. Mueller Institute for Structural William & Mary, Williamsburg, VA Biology, Biozentrum, Basel, Switzerland, 1943 B290 Simulation Assisted 2 1965 B312 A Role for the Karyopherin Department of Cell and Molecular Biology, 1 Interpretation of FRAP Experiments. J. C. Kap123p in Microtubule Stability. C. Ptak, A. M. Northwestern University, Feinberg School of 1 1 2 Schaff, A. Cowan, F. Morgan, Y. Li, L. Loew; Anderson, R. J. Scott, D. J. Dilworth, J. D. Medicine, Chicago, IL 2 1 1 Center for Cell Analysis and Modeling, University of Aitchison, R. W. Wozniak ; Cell Biology, Connecticut Health Center, Farmington, CT 1954 B301 Nuclear Morphogenesis in University of Alberta, Edmonton, AB, Canada, 2 Cellularising Drosophila Embryos. B. Hampoelz, Institute for Systems Biology, Seattle, WA Y. Azou, T. Lecuit; IBDML, CNRS, Marseille, Nuclear Matrix and Nuclear Architecture 1966 B313 Osmotic Stress Upregulates France Nup88 Expression to Retain TonEBP in the Nucleus in Inner Medullary Collecting Duct 1944 B291 Proteome Analyses of the HeLa 1955 B302 Megator Is Part of a Labile (IMCD3) Cells. A. Andres-Hernando, M. A. Cell Nuclear Matrix Fraction. K. Ishii,1 Y. Hirano,2 Nuclear Matrix That Persists during Mitosis in 1 Lanaspa, C. J. Rivard, N. E. Almeida, T. Berl; K. Takeyasu,2 K. Furukawa,1 T. Horigome1; Live Drosophila S2 Cells. M. P. Lince-Faria, H. 1,2 1 Renal Medicine, University of Colorado Health 1Graduate School of Science and Technology, Maiato ; Genética Molecular, Intituto de Biologia Sciences Center, Denver, CO Niigata University, Niigata, Japan, 2Graduate Molecular e Celular do Porto, Porto, Portugal, 2Faculdade de Medicina, Universidade do Porto, School of Biostudies, Kyoto University, Kyoto, 1967 B314 Ca2+ Regulates CTP: Japan Portugal Phosphocholine Cytidylyltransferase Nuclear Translocation via Binding to 14-3-3␨ in Murine 1945 B292 Lamin A Is a Filamentous Actin 1956 B303 A Conserved Protein Interaction Lung Epithelia. M. Agassandian, C. C. Schuster, Bundling Protein. D. Simon, M. S. Zastrow, K. L. Map of STIP: Insights into the Molecular B. Chen, R. K. Mallampalli; University of Iowa, Wilson; Cell Biology, The Johns Hopkins University Composition and Dynamic Organization of the Iowa City, IA School of Medicine, Baltimore, MD Nuclear Body Stiposome. Q. Ji, M. Ye, T. Ye, Y. Chen, C. Huang; Laboratory of Biochemistry and 1968 B315 Origin of the Nucleus to 1946 B293 Nuclear Lamins Form Different Molecular Genetics, Lindsley F. Kimball Research Safeguard Ribosome Biogenesis in a Chimeric Structures in the Lamina and the Nucleoplasm Institute, New York, NY Cell. G. Jékely; MPI Developmental Biology, Suggesting Different Roles in Chromatin Tübingen, Germany Organization and Transcription. T. Shimi,1 K. 1957 B304 Role of Nuclear Envelope 1 1 2 2 Pfleghaar, S. Kojima, C. Pack, M. Kinjo, R. D. Localized Glycosidase (NET37) in Myogenesis. 1969 B316 The Karyopherin Sxm1/Kap108 1 1 Goldman ; Cell and Molecular Biology, Feinberg K. Datta, G. Tinglu, M. Huber, L. Gerace; Cell Regulates Gene Expression under Normal and School of Medicine, Northwestern University, Biology, The Scripps Research Institute, San Oxidative Stress Conditions in S. cerevisiae. K. 2 Chicago, IL, Supramolecular Biophysics, Research Diego, CA D. Belanger,1 D. Tkachev,1 K. G. Belanger,1 S. J. Institute for Electronic Science, Hokkaido Geier,1 R. Aurora2; 1Biology, Colgate University, University, Sapporo, Japan Nuclear Import and Export Signals Hamilton, NY, 2Molecular Microbiology and Immunology, St. Louis University School of 1947 B294 Lamin A Disruption in Medicine, St. Louis, MO Hutchinson-Guilford Progeria Syndrome Causes 1958 B305 Structural Alternations Regulate Defects in Nuclear Pore Complex Structure. J. Nuclear Import of aristaless-related homeobox 1970 B317 The High Mobility Group Box 1 1 1 1 B. Kelley, B. M. Paschal; Center for Cell Signaling, (Arx) Protein. T. Tao, Z. Peng, W. Lin, L. Cai, Transcription Factor Nhp6Ap Enters the 1 1 1 1 1 University of Virginia, Charlottesville, VA Y. Quan, C. Huang, G. Ke, X. Meng, Z. Ji, J. Nucleus by a -dependent, Ran- 2 3 1 Golden, A. Tartakoff ; Xiamen University School independent Pathway. J. Hanover,1 M. O'Kane,1 1948 B295 Comparison of and of Life Sciences, Xiamen, Fujian, China, D. Love,1 Y. Yen,2 R. Johnson,2 W. Prinz1; Chromogranin Effect on Inositol 1,4,5- 2 Department of Pathology, University of 1NIDDK, National Institutes of Health, Bethesda, trisphosphate Sensitivity of Cytoplasmic and Pennsylvania School of Medicine, Philadephia, PA, MD, 2Department of Biological Chemistry, UCLA Nucleoplasmic Inositol 1,4,5-trisphosphate 3Department of Pathology, Case Western Reserve 2+ Medical School, Los Angeles, CA Receptor/Ca Channels. Y. H. Huh, K. D. Kim, S. University School of Medicine, Cleveland, OH H. Yoo; Biochemistry, Inha University College of 1971 B318 The Mechanism of Ran- Medicine, Incheon, Republic of Korea 1959 B306 Single-Molecule Force modulated Binding of RCC1 to Chromatin. Y. Measurement Revealed the Characteristics of Hao,1 I. G. Macara2; 1Department of Cell Biology, 1949 B296 Sub-nuclear Structures and Protein Transport through Nuclear Pore University of Virginia, Charlottesville, VA, Their Dynamics Revealed by a Set of Nuclear Complex. S. Otsuka, K. Takeyasu, S. H. 2Department of Microbiology, Center for Cell Antibodies. M. Kumeta, Y. Hirai, H. Takahashi, Y. Yoshimura; Graduate School of Biostudies, Kyoto Signaling, School of Medicine, University of Hirano, S. Yoshimura, K. Takeyasu; Graduate University, Kyoto, Japan Virginia, Charlottesville, VA School of Biostudies, Kyoto University, Kyoto, Japan

155 TUESDAY The American Society for Cell Biology 47th Annual Meeting Poster Session 3 B319–B352 December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org

1972 B319 Nuclear Pore Complex- 1983 B332 Ring Finger Protein 13 1993 B342 Identification of a Novel Sorting associated SUMO Isopeptidase Functions as a Undergoes Extensive Post-Translational Signal Required for Transition from the trans- Karyopherin-alpha Releasing Factor. J. D. Modification. S. Carmicle, J. P. Bocock, A. H. Golgi Cisterna to the TGN. B. E. Schaub, M. Goeres, M. Matunis; Biochemistry and Molecular Erickson; Biochemistry, University of North Carolina Oertli, E. G. Berger, J. Rohrer; Physiology, Biology, Johns Hopkins University, Baltimore, MD at Chapel Hill, Chapel Hill, NC University of Zurich, Zurich, Switzerland

1973 B320 The Expression of UbD: Cellular 1984 B333 Mechanisms of Endocytosis and 1994 B343 Characterization of Multiple Localization and Association with Mallory Body Sorting Revealed by Functional Genomics. C. Overlapping Trafficking Signals in an N-terminal Formation. J. V. Oliva, B. A. French, F. Amidi, F. Collinet,1 Y. Kalaidzidis,1 M. Stöter,2 C. Bradshaw,1 Region of a Membrane Protein of the Trans- Bardag-Gorce, J. Li, S. W. French; Pathology, D. Kenski,3 A. Niederlein,2 B. Habermann,1 F. Golgi Network. H. Odaman, M. Kirchberg, S. F. Harbor–UCLA Medical Center, Torrance, CA Buchholz,1 R. Henschel,4 M. Müller,4 W. Nagel,4 E. Nothwehr; Biological Sciences, University of Krausz,2 E. Fava,2 M. Zerial1; 1Max Planck Institute Missouri–Columbia, Columbia, MO for Molecular Cell Biology and Genetics, Dresden, Endosomes and Lysosomes Germany, 2High-Content Screening Technology 1995 B344 Silencing TGN Golgins to Define Development Studio, Max Planck Institute for Retrograde Transport Pathway. Z. Lieu, M. 1974 B323 Intracellular Chloride Flux Molecular Cell Biology and Genetics, Dresden, Derby, C. Hart, P. Gunn, P. Gleeson; Biochemistry Directs Endosomal Membrane Dynamics. C. C. Germany, 3Genentech Inc., South San Francisco, and Molecular Biology, Bio21 Molecular Science Scott, T. Falguières, J. Gruenberg; Section of CA, 4Center for Information Services and High and Biotechnology Institute, Melbourne, Australia Chemistry and Biochemistry, Univeristy of Geneva, Performance Computing, Technische Universität 1996 B345 CVAK90 Is a Novel Regulator of Geneva, Switzerland Dresden, Dresden, Germany COPI-mediated Retrograde Vesicle Traffic. J. L. 1975 B324 Mucolipin-1 Channel Activity Is 1985 B334 A Genomic Screen to Identify Burman, L. Bourbonniere, T. Stroh, P. S. Regulated by Protein Kinase A Mediated ENV Genes in S. cerevisiae. E. Gharakhanian; McPherson; Neurology and Neurosurgery, Montreal Phosphorylation. S. Vergarajauregui,1 R. Biological Sciences, California State University, Neurological Institute, McGill University, Montreal, Oberdick,2 K. Kiselyov,2 R. Puertollano1; Long Beach, CA PQ, Canada 1Laboratory of Cell Biology, NHLBI, National 1997 B346 Functional Involvement of TMF/ Institutes of Health, Bethesda, MD, 2Department of 1986 B335 Genetic Analysis of the Role of the RabGAP RN-Tre in Drosophila. L. Shi,1 T. ARA160 in Rab6-dependent Retrograde Biological Sciences, University of Pittsburgh, 1,2 2,3 Houalla,2 Y. Rao2; 1Biology, McGill University Membrane Traffic. J. Yamane, A. Kubo, K. Pittsburgh, PA 4 5 6 Health Centre, Montreal, PQ, Canada, 2Centre for Nakayama, A. Yuba-Kubo, T. Katsuno, S. 1,2 2,6 1 1976 B325 The Nature of the Counter-Ion Research in Neuroscience, McGill University Health Tsukita, S. Tsukita ; Cell Biology, Kyoto 2 Conductance Required for Lysosomal Centre, Montreal, PQ, Canada University, Kyoto, Japan, Solution Oriented Acidification. B. E. Steinberg, A. Brodovitch, S. Research for Science and Technology, Kyoto, Grinstein; Institute of Medical Science, University of 1987 B336 Characterization of Trak1, a Japan, 3Dermatology, Keio University School of Toronto, Toronto, ON, Canada Putative Trafficking Protein Linked to the Medicine, Tokyo, Japan, 4Physiological Chemistry, Neurological Dysfunction Hypertonia. E. A. Kyoto University, Kyoto, Japan, 5Mitsubishi Kagaku 1977 B326 Immunoisolation and Partial Webber, L. Li, L. Chin; Pharmacology, Emory Institute of Life Sciences, Tokyo, Japan, Characterization of CFTR-enriched Endosomal University School of Medicine, Atlanta, GA 6Laboratory of Biological Science, Osaka Vesicles. G. D. Heda,1,2 G. Dabas,2 C. R. University, Osaka, Japan Marino3,2; 1Research Service, V.A. Medical Center, 1988 B337 GLP-1-induced Generation of Memphis, TN, 2Medicine, The University of cADPR and NAADP in a Spatiotemporal Manner 1998 B347 Rab6 Regulates Both ZW10/ Tennessee Health Sciences Center, Memphis, TN, in Pancreatic ␤ Cells. B. Kim, K. Park, U. Kim; RINT-1 and COG Complex Dependent Golgi 3Research and Medical Services, V.A. Medical Biochemistry, Chonbuk National University Medical Trafficking and Homeostasis. Y. Sun, A. Center, Memphis, TN School, Jeonju, Republic of Korea Shestakova, L. Hunt, S. Sehgal, V. Lupashin, B. Storrie; Physiology and Biophysics, University of 1978 B327 Live Imaging of Transferrin and 1989 B338 The Phylogeny of DNase-II: An Arkansas for Medical Sciences, Little Rock, AR NgCAM Sorting in Somatodendritic Endosomes Enzyme Essential Phagocyte-mediated DNA of Hippocampal Neurons. Z. M. Lasiecka, C. Yap, Degradation. M. Shpak, R. J. Aguilera; Biology, 1999 B348 Novel Tests That Reveal B. Winckler; Neuroscience, University of Virginia, University of Texas at El Paso, El Paso, TX Specific Role of the Conserved Oligomeric Charlottesville, VA Golgi (COG) Complex in Golgi Dynamic and 1990 B339 Analysis of Cyclodextrin- Protein Glycosylation. R. D. Smith, V. Lupashin; 1979 B328 Endosomal Trafficking of induced Cholesterol Efflux on Acid Physiology and Biophysics, University of Arkansas NgCAM in Neuron. C. Yap, Z. Lasiecka, B. Sphingomyelinase Activity. H. K. Rush, J. W. for Medical Sciences, Little Rock, AR Winckler; University of Virginia, Charlottesville, VA Reagan; Biology, Middle Tennessee State University, Murfreesboro, TN 2000 B349 The Conserved Oligomeric Golgi 1980 B329 Assembly of Clathrin and TGN/ (COG) Complex Directly Interacts with the t- Endosome Adaptor Complexes Is Coordinated SNARE Sed5p/Syntaxin5 Enhancing Stability of by Auto-regulatory Sequences in the Clathrin Golgi Complex the intra-Golgi SNARE Complex. V. Lupashin, A. Adaptor Gga2. M. C. Duncan, C. Phu, G. Shestakova, R. D. Smith, O. Pavliv, G. Khaidakova; Costaguta, G. S. Payne; Biological Chemistry, 1991 B340 New Rab Proteins Involved in Physiology and Biophysics, University of Arkansas UCLA Medical School, Los Angeles, CA ER-Golgi Trafficking. S. Y. Dejgaard,1 A. for Medical Sciences, Little Rock, AR Murshid,1 A. Erman,1 O. Kizilay,1 D. Verbich,1 R. 1981 B330 Human OCA2 Localizes to Lodge,2 K. Dejgaard,3 T. Ly-Hartig,4 J. C. 2001 B350 Structural Characterization of H. Mature Melanosomes and Requires N-terminal Simpson,4 R. Pepperkok,4 J. F. Presley1; 1Anatomy sapiens Cog4. B. C. Richardson, D. Ungar, A. Dileucine Motifs and BLOC-1/BLOC-2 for Its and Cell Biology, McGill University, Montreal, PQ, Nakamura, F. M. Hughson; Molecular Biology, 1 1 Trafficking. A. Sitaram, A. C. Theos, D. C. Canada, 2Laboratoire d"Immunoretrovirologie, Princeton University, Princeton, NJ 1 1 1 Harper, S. Rao, W. De Jesus-Rojas, D. Centre de Recherche d'Infectiologie–CHUL, 2 2 1 2002 B351 Golgi Compartmentalization Altimare, M. V. Schiaffino, M. S. Marks ; Quebec, PQ, Canada, 3Biochemistry, McGill 1 Requires Coat-Tether Interaction. Y. Guo, V. Pathology and Lab Medicine, University of University, Montreal, PQ, Canada, 4Cell Biology 2 Punj, D. Sengupta, A. D. Linstedt; Biological Pennsylvania, Philadelphia, PA, DIBIT, Scientific and Biophysics Unit, EMBL, Heidelberg, Germany Institute San Raffaele, Milan, Italy Sciences, Carnegie Mellon University, Pittsburgh, 1992 B341 Components Involved in Golgi PA 1982 B331 Synaptic Vesicle Protein Cisternal Maturation in the Yeast S. cerevisiae. 2003 B352 The Mitotically Regulated Golgi Targeting Regulation by the AP-3 and BLOC-1 E. Papanikou, E. Losev, B. Glick; Department of Protein GRASP55 Is Necessary for Lateral Lysosomal Sorting Machinery. K. A. Newell- Molecular Genetics and Cell Biology, University of 1 2 1 1 Linkages between Golgi Stacks. T. N. Feinstein, Litwa, S. Chintala, G. Salazar, V. Faundez ; Chicago, Chicago, IL 1Cell Biology, Emory University, Atlanta, GA, A. D. Linstedt; Biological Sciences, Carnegie 2Molecular and Cellular Biology, Roswell Park Mellon University, Pittsburgh, PA Cancer Institute, Buffalo, NY

156 The American Society for Cell Biology 47th Annual Meeting TUESDAY December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org Poster Session 3 B353–B379

2004 B353 The Role of Golgins and Their Grown Factors in Development Mammalian Development Associated GTPases in the Regulation of Golgi Structure. L. A. Satkamp,1 B. S. Glick2; 2013 B363 Disruption of the Akt Signalling 2021 B371 A Maternal Complex Essential 1Biochemistry and Molecular Biology, University of Pathway in the CITED1 KO Pubertal Mammary for Progression Beyond the Early Cleavage Chicago, Chicago, IL, 2Molecular Genetics and Cell Gland. S. Napoletano,1 J. McBryan,1 J. Howlin,2 T. Stage of Mouse Embryogenesis. L. Li, B. Biology, University of Chicago, Chicago, IL Shioda,3 F. Martin1; 1School of Biomolecular and Baibakokv, J. Dean; Laboratory of Cellular and 2005 B354 Analysis of Grh1p in Secretory Biomedical Science, UCD Conway Institute, Dublin, Developmental Biology, NIDDK/NIH, Bethesda, MD 2 Transport in the Budding Yeasts Ireland, Department of Laboratory Medicine, Cell 2022 B372 Maternal Serotonin is Essential Saccharomyces cerevisiae and Pichia pastoris. and Experimental Pathology, Lund University, Clinical Research Centre, Malmo, Sweden, for Normal Mouse Development and Survival. C. S. K. Levi, B. S. Glick; Molecular Genetics and Cell 1 1 1 2 3Laboratory of Tumour Biology, Massachusetts Fligny, S. Hatia, E. Bayard, J. Launay, J. Biology, University of Chicago, Chicago, IL 1 1 1 1 General Hospital Cancer Centre, Charlestown, MA Mallet, G. Vodjdani, F. Cote ; Science de la Vie, 2 2006 B355 Membrane-associated p115 Is CNRS, Paris, France, Biochemistry, Hôpital Selectively Cleaved by Caspase-3 during 2014 B364 Astroglial Development and Lariboisière, Paris, France Apoptosis. P. How, D. Shields; Developmental and Growth in SVZ-derived Clonal Neurospheres Is 2023 B373 New Insights into Androgen- Molecular Biology, Albert Einstein College of Regulated by Vascular Endothelial Growth dependent Wolffian Duct Rescue in the Male Medicine, Bronx, NY Factor (VEGF). N. Mani, J. Krum, J. Rosentein; Anatomy and Cell Biology, George Washington and Female Rat. M. Welsh, R. Sharpe, L. Smith, 2007 B356 Src-kinase Regulates the University, Washington, DC P. Saunders; MRC Human Reproductive Sciences Structural Integrity and Secretory Function of Unit, Edinburgh, United Kingdom the Golgi Apparatus via Dynamin 2 Activation. 2015 B365 Proteomic Analysis of 2024 B374 Strain-induced Cell Behaviors in S. Weller,1 C. Chini,1 M. A. McNiven2; 1Division of Macrophages Stimulated with Oxidized 1,2 3 Intact Embryonic Tissues. S. D. Joshi, L. A. Gastroenterology and Hepatology, Mayo Clinic, Galectin-1. K. Yoshimura, F. Kametani, K. 2 4 2 5 Davidson; Bioengineering, University of Pittsburgh, Rochester, MN, 2Division of Gastroenterology and Fujimaki, H. Horie, S. Watanabe, T. Kadoya ; 1 Pittsburgh, PA Hepatology and Department of Biochemistry and Rehabilitation, Nihon Institute of Medical Science, Moroyama, Japan, 2Physiology, Saitama Medical Molecular Biology, Mayo Clinic, Rochester, MN 2025 B375 Differential Expression of University, Moroyama, Japan, 3Tokyo Institute of Insulin-like Growth Factor Binding Protein-5 2008 B357 Identification of a Psychiatry, Tokyo Metropolitan Organization for (IGFBP5) in the Normal and Neural Tube Transmembrane Lysophosphatidic Acid Medical Research, Tokyo, Japan, 4Institute of Defective Mice during the Developmental Stage Acyltransferase That Mediates Golgi Structure Frontier Oral Science, Kanagawa Dental College, of Neurulation. H. L. Li,1 W. Q. Cai,1 C. H. and Function. J. A. Schmidt, W. J. Brown; Molec. Kanagawa, Japan, 5CMC Research and Tzang,2 Z. Yang,3 Z. G. Li,1 M. S. Yang2; Biol. and Genetics, Cornell University, Ithaca, NY Development Labs, Kirin Pharma Co. Ltd, Gunnma, 1Department of Histology and Embryology, Institute Japan 2009 B358 The Role of Golgi Structure in of Neuroscience, The Third Military Medical 2 Sphingomyelin Synthesis. S. Chandran, C. E. 2016 B366 Protein Kinase C Mediates University, Chongqing, China, Department of Machamer; Cell Biology, Johns Hopkins University Fibroblast Growth Factor 2-induced Expression Biology and Chemistry, City University of Hong 3 School of Medicine, Baltimore, MD of Interferon-tau in Bovine Trophectoderm. Q. Kong, Hong Kong, China, Department of Yang, K. A. Pennington, S. E. Johnson, A. D. Ealy; Neurobiology, Institute of Neuroscience, The Third 2010 B359 Regulation of Nucleotide Animal Sciences, University of Florida, Gainesville, Military Medical University, Chongqing, China Binding to Yeast Arl1 by Mon2. D. R. Chaves, C. FL M. A. Manlandro, V. R. Palanivel, A. G. Rosenwald; 2026 B376 Functional Characterization of Biology, Georgetown University, Washington, DC 2017 B367 Neurotrophin-induced Pregnancy-specific Glycoprotein 23: Not All 1 Upregulation of p75NTR via a Protein Kinase C- PSGs Are Created Equal. J. A. Wu, B. L. 2 2 2 2 2011 B360 Clathrin Isoform CHC22 Delta-dependent Mechanism. S. L. Rankin, C. S. Johnson, C. T. Ha, Y. Chen, J. W. Warren, G. 2 1 Organizes the GLUT4 Transporter in Human Guy, M. Rahimtula, K. M. Mearow; Basic Medical S. Dveskler ; Molecular and Cellular Biology, Skeletal Muscle. S. Vassilopoulos, S. Hoshino, C. Sciences, Memorial University, St. John's, NF, Uniformed Services University, Bethesda, MD, 2 Esk, F. M. Brodsky; Hooper Foundation, University Canada Pathology, Uniformed Services University, of California, San Francisco, San Francisco, CA Bethesda, MD 2018 B368 The Synaptotagmin-like Protein 2012 B361 Proteomic Analysis of C2PI Determines FGF Receptor Internalization 2027 B377 Abnormal Development of Basolaterally-targeted, Flow-sorted Exocytic and Temporal Aspects of Signaling. T. Moss, S. Neural Crest- and Pharyngeal Arch-derived 1 1 1 1 Vesicles. Z. Cao, C. Li, J. Higginbotham, J. Jean, M. Tremblay, J. Baril; Medical Biology and Organs in FRS2alpha 2F Mutant Mice. M. Ito, Y. 2 3,4 1 2 3 1 4 Franklin, D. Tabb, R. Graves-Deal, L. Cancer Research Centre, Laval University and Kameda, K. Takamori, J. Imaki, N. Gotoh ; 5,6 2,5,6 7 1 Lapierre, J. Goldenring, A. Ham, R. CHUQ-HDQ, Quebec, PQ, Canada Department of Developmental Anatomy and Coffey1,2,6; 1Department of Medicine, Vanderbilt Regenerative Biology, National Defense Medical University, Nashville, TN, 2Cell and Developmental 2019 B369 ROCK1 Expression Is Regulated College, Saitama, Japan, 2Department of Anatomy, Biology, Vanderbilt University, Nashville, TN, by TGF␤3 and ALK2 during Valvuloseptal Kitasato University School of Medicine, 3Biochemistry, Vanderbilt University, Nashville, TN, Endocardial Cushion Formation. M. Sakabe,1 H. Sagamihara, Japan, 3Department of Human 4Biomedical Informatics, Vanderbilt University, Sakata,1 H. Matsui,1 K. Ikeda,1 T. Yamagishi,2 Y. Development & Fostering, Division of Pediatric Nashville, TN, 5Surgery, Vanderbilt University, Nakajima1; 1Department of Anatomy and Cell Dentistry, Meikai University School of Dentistry, Nashville, TN, 6Veterans Affairs Medical Center, Biology, Osaka City University, Osaka, Japan, Saitama, Japan, 4Division of Systems Medical Vanderbilt University, Nashville, TN, 7The 2Department of Anatomy, Saitama Medical Technology, Institute of Medical Science, University Proteomics Laboratory of the Mass Spectrometry University, Saitama, Japan of Tokyo, Tokyo, Japan Research Center, Vanderbilt University, Nashville, TN 2020 B370 Development of the Common 2028 B378 Selenoprotein W Protects C2C12 Precursor Cells for Prolactin and Growth Cells from Oxidative Stress at the Early Stage Hormone Cells in the Fetal Pituitary Gland of of Differentiation. Y. Park, O. Noh, I. Kim; The the Mouse. K. Ogasawara, H. Nogami, S. Hisano; Laboratory of Cellular and Molecular Biochemistry, Department of Neuroendocrinology, Institute of School of Life Sciences and Biotechnology, Korea Basic Medical Sciences, University of Tsukuba, University, Seoul, Republic of Korea Tsukuba, Ibaraki, Japan 2029 B379 Selenoprotein W Is Involved in Skeletal Muscle Differentiation. O. Noh, Y. Park, I. Kim; Laboratory of Cellular and Molecular Biochemistry, School of Life Sciences and Biotechnology, Korea University, Seoul, Republic of Korea

157 TUESDAY The American Society for Cell Biology 47th Annual Meeting Poster Session 3 B380–B412 December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org

2030 B380 Molecular Regulation of Shh 2042 B392 The Effect of Antifreeze 2052 B402 Germ Line Determination Trafficking in Neurons. S. T. Beug,1 R. J. Parks,1 Glycoprotein on Cryopreservation of Boar Strategies: Insights from the Echindoderms. C. H. M. McBride,2 V. A. Wallace1; 1Ottawa Health Sperm. T. Jo, J. Byun, J. Lee, Y. Kim, H. Kim, D. E. Juliano, G. M. Wessel; MCB, Brown University, Research Institute, Ottawa, ON, Canada, Roh, Y. Hwang, D. Kim; Division of Biological Providence, RI 2University of Ottawa Heart Institute, Ottawa, ON, Science, Gachon University of Medicine and Canada Science, Incheon, Republic of Korea 2053 B403 Phosphatidic Acid (PA) Activates Xenopus Src and Phospholipase C 2031 B381 Identification and 2043 B393 In Vivo Exposure Male Whereas PIP Strip Fat Blots Show Src Binds Characterization of Oreo, a Mouse Model of Reproductive System to Methoxychlor. D. Roh,1 PA. B. J. Stith,1 J. Juergens,1 J. Snyder,1 R. Dominant Microcephaly and Hypopigmentation. H. Kim,1 J. Lee,1 J. Byun,1 Y. Kim,1 T. Jo,1 S. Do,2 Bates,1 J. Ash,1 D. Petcoff,2 E. Cook,2 A. Barkans,2 D. L. Silver, D. Watkins-Chow, C. Rivas, G. Elliot, Y. Hwang,1 D. Kim1; 1Division of Biological M. Lintz2; 1Biology, University of Colorado Denver, A. Incao, B. Pavan; GDRB, NHGRI, Bethesda, MD Science, Gachon University of Medicine and Denver, CO, 2Biology, Metropolitan State College, Science, Incheon, Republic of Korea, 2Clinical Denver, CO 2032 B382 Tissue Stiffness and Its Pathology, College of Veterinary Medicine, Konkuk Molecular Source in Developing Frog Embryos. University, Seoul, Republic of Korea 2054 B404 Characterization Of a Mouse J. Zhou, L. Davidson; Bioengineering, University of Gene Trap Mutation Disrupting Highly Pittsburgh, Pittsburgh, PA 2044 B394 Intratracheal Instillation of Asian Conserved Stem Cell Factor - Pumilio 1. Y. Dust and Reproductive Abnormalities. J. Lee,1 Chen, E. Xu; Department of Obstetrics and 2033 B383 Transient F-actin T. Jo,1 Y. Kim,1 J. Byun,1 H. Kim,1 D. Roh,1 S. Do,2 Gynecology, and Center for Genetic Medicine, Depolymerization Disrupts Morphogenesis in M. Song,3 Y. Hwang,1 D. Kim1; 1Division of Northwestern University, Chicago, IL Frog Embryos. H. Kim, L. A. Davidson; Biological Science, Gachon University of Medicine Bioengineering, University of Pittsburgh, Pittsburgh, and Science, Incheon, Republic of Korea, 2Clinical 2055 B405 The Forkhead Transcription PA Pathology, College of Veterinary Medicine, Konkuk Factor FoxY: A Potential Transcriptional University, Seoul, Republic of Korea, 3Toxicity Regulator of Germ-Line Genes. J. L. Song, G. M. 2034 B384 Calnexin during Embryonic Evaluation Department, Korea Environment & Wessel; Molecular Biology, Cellular Biology, and Development. H. Coe, J. Groenendyk, S. Aldred, Merchandise Testing Institute, Incheon, Republic of Biochemistry, Brown University, Providence, RI M. Michalak; Biochemistry and Pediatrics, Korea University of Alberta, Edmonton, AB, Canada 2056 B406 GAK-1, an Autosome-specific 2045 B395 Multiple Roles for Ubiquitination Protein Required for Proper Pairing and 2035 B385 Cardiotrophin-1 Inhibits Skeletal in Caenorhabditis elegans. M. Kulkarni, H. Smith; Segregation of the X-chromosome in C. Myogenesis by Activation of MEK. T. Miyake, N. 1 2 Center for Advanced Research in Biotechnology, elegans. C. R. Wagner, L. Kuervers, D. L. Alli, A. Aziz, J. C. McDermott; Biology, York 2 1 1 Rockville, MD Baillie, J. L. Yanowitz ; Carnegie Institution, University, Toronto, ON, Canada Baltimore, MD, 2Institute of Molecular Biology and 2046 B396 Actin Dynamics during C. Biochemistry, Simon Fraser University, Burnaby, 2036 B386 The Prader-Willi Syndrome elegans Oogenesis and Fertilization Reveals BC, Canada Protein necdin Promotes Normal Muscle Cytoskeletal Asymmetries before Fertilization. Development. J. R. Bush, R. Wevrick; Medical N. Velarde, F. Piano; Biology, New York University, 2057 B407 The Regulation of IP3 Receptor Genetics, University of Alberta, Edmonton, AB, New York, NY Function during Xenopus Oocyte Maturation. L. Canada Sun,1 K. Machaca,1 S. Haun,1 R. Jones,2 R. 2047 B397 Evaluation of Efficiency between Edmondson2; 1University of Arkansas for Medical Germ Cells and Fertilization FISH and CISH to Sex Preselection of Boar Sciences, Little Rock, AR, 2National Center for Sperm. J. Byun, H. Kim, D. Roh, J. Lee, Y. Kim, T. Toxicological Research, Little Rock, AR Jo, Y. Hwang, D. Kim; Division of Biological 2037 B387 Cross-Species Chemotaxis and Science, Gachon University of Medicine and Crisp Family Gene Expression in Xenopus Science, Incheon, Republic of Korea Membrane Domains and Polarity Tropicalis. L. Burnett, S. Boyles, C. Spencer, A. Bieber, D. Chandler; Arizona State University, 2048 B398 Microarray Analysis of Gene 2058 B409 Nullo Controls Local Tempe, AZ Expression in Mouse Oocytes Matured In Vitro Endocytosis via F-actin to Establish Furrow during the First Wave of Folliculogenesis. O. Polarity at the Onset of Drosophila 2038 B388 Autophagic Control of the Suzuki, M. Koura, K. Takano, Y. Noguchi, K. Uchio- Cellularization. A. Sokac,1 E. Wieschaus1,2; Development of Murine Oocytes. Y. Takahashi, Yamada, J. Matsuda; Laboratory of Experimental 1Department of Molecular Biology, Princeton H. Saito; Perinatal Medicine and Maternal Care, Animal Models, National Institute of Biomedical University, Princeton, NJ, 2Howard Hughes Medical National Center for Child Health and Development, Innovation, Ibaraki, Japan Institute, Princeton, NJ Tokyo, Japan 2049 B399 Increase in Intracellular cAMP 2059 B410 Visualizing Membrane Domains 2039 B389 Testis Leucine Rich Repeat, a Regulates Several Events Related to GVBD in Live Cells: Micron-Scale Sterol Segregation Candidate Protein Phosphatase-1 Regulatory during Initiation of Oocyte Maturation in Cytaeis in Live Sperm Membranes. A. J. Travis,1 V. Subunit in the Testis. R. Wang, A. O. Sperry; uchidae. N. Takeda,1 D. Ryusaku,2 K. Keiichiro3; Selvaraj,1 A. Asano,1 D. E. Buttke,1 P. Sengupta,2 Anatomy and Cell Biology, East Carolina University, 1Department of Biosciences and Informatics, Keio D. A. Holowka,2 R. S. Weiss1; 1Biomedical Greenville, NC University, Yokohama, Japan, 2Department of Sciences, Cornell University, Ithaca, NY, 2040 B390 A Broader Role for E2F6 in the Biology, Miyagi University of Education, Sendai, 2Chemistry and Chemical Biology, Cornell 3 Repression of Meiosis-specific Genes. S. M. Japan, Research Center for Marine Biology, University, Ithaca, NY Kehoe,1 M. Oka,1 N. Reichert,2 S. Gaubatz,2 N. Tohoku University, Aomori, Japan 1 1 2060 B411 Biochemical Characterization of Terada ; Pathology, University of Florida, 2050 B400 Identification a Novel Cytoplasm 2Department of Physiological Membrane Sub-domains in Murine Sperm Gainesville, FL, Localization of Seawi in Testes and Ovaries. L. Chemistry I, Biocenter, University of Würzburg, Am Reveals at Least 3 Types of Membrane Raft. A. S. Chuang,1 S. A. Seipel,1 A. J. Rodriguez,2 E. M. 1 V. Selvaraj,1 D. E. Buttke,1 S. Castle,2 S. Hubland, Würzburg, Germany Asano, Bonder1; 1Biological Sciences, Rutgers University, B. Levery,2 A. J. Travis1; 1Baker Institute for Animal 2 2041 B391 The Effect of Amides on Newark, NJ, Anatomy and Structural Biology, Health, Cornell University, Ithaca, NY, 2Department Cryopreservation of Boar Sperm. D. Kim, T. Jo, Albert Einstein College of Medicine, Bronx, NY of Chemistry, University of New Hampshire, Durham, NH J. Byun, J. Lee, Y. Kim, H. Kim, D. Roh, Y. Hwang; 2051 B401 Differential Declines in Division of Biological Science, Gachon University of Hyperpolarization-activated Cation (HCN) 2061 B412 Involvement of Lipid Rafts in Medicine and Science, Incheon, Republic of Korea Channels in Rat Ovaries after Exposure to the Laminin-mediated AQP4 and Dystroglycan Cisplatin. J. Yeh, J. Peresie, C. Page, B. Kim, A. Co-clustering in Cortical Astrocytes. G. P. Noel, Arroyo; Gynecology-Obstetrics, University at H. Moukhles; Cellular and Physiological Sciences, Buffalo, Buffalo, NY University of British Columbia, Vancouver, BC, Canada

158 The American Society for Cell Biology 47th Annual Meeting TUESDAY December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org Poster Session 3 B413–B444

2062 B413 Membrane Raft Regulation of 2073 B424 Rafting Till Freedom. Z. Bacso,1 2083 B434 Oculocerebrorenal Syndrome of 1 1 1 2 Phosphatidylinositol 4,5-Bisphosphate (PIP2) K. Goda, H. Nagy, Z. Szabó, F. Fenyvesi, Z. Lowe Protein (OCRL) Function in Polarized Signaling. C. M. Johnson, W. A. Rodgers; Birkó,3 T. Janáky,4 G. Szabó1; 1Biophysics and Cell Membrane Traffic. C. J. Guerriero, S. Cui, Y. Lai, Cardiovascular Biology, Oklahoma Medical Biology, University of Debrecen, Debrecen, O. A. Weisz; Cell Biology and Molecular Research Foundation, Oklahoma City, OK Hungary, 2Pharmaceutical Technology, University of Physiology, University of Pittsburgh, Pittsburgh, PA Debrecen, Debrecen, Hungary, 3Human Genetics, 2063 B414 A Systems Approach to Plasma University of Debrecen, Debrecen, Hungary, 2084 B435 Phospholipase D1 Regulates 1 Membrane Organization and Dynamics. F. Spira, 4Medical Chemistry, University of Szeged, Szeged, RhoA Expression In Mast Cells. L. M. Nicoletti, 2 2 1 A. H. Crevenna, R. Wedlich-Soldner; Cellular Hungary M. Jamur, C. Oliver ; Clinical Medicine, Dynamics and Cell Patterning, Max-Planck-Institute Faculdade de Medicina de Ribeirão Preto - USP, of Biochemistry, Martinsried, Germany 2074 B425 Basolateral Retention of the Ribeirão Preto, SP, Brazil, 2Cell and Molecular EGFR Is Coupled to a Consensus AP-1 Binding Biology, Faculdade de Medicina de Ribeirão Preto - 2064 B415 WITHDRAWN Site in Polarized Epithelial Cells. S. P. Ryan,1 C. USP, Ribeirão Preto, SP, Brazil R. Carlin2; 1Department of Molecular Biology and 2065 B416 Protein Dynamics at Specific 2085 B436 Depletion of ␤-COP Reveals a Domains of the in Microbiology, Case Western Reserve University, Cleveland, OH, 2Department of Physiology and Role for COP-I in Biosynthetic Transport of Skeletal Muscle Cells. V. Cusimano, E. 1 1 Biophysics, Case Western Reserve University, Caveolin-1. M. L. Styers, A. K. O'Connor, R. Giacomello, V. Sorrentino; Neuroscience, University 1 2 1 1 Cleveland, OH Grabski, E. Cormet-Boyaka, E. Sztul ; Cell of Siena, Siena, Italy Biology, University of Alabama at Birmingham, 2075 B426 The Ankyrin-G Adaptor Birmingham, AL, 2Pulmonary Critical Care and 2066 B417 Atypical PKC Mediates Ezrin Hypothesis and Basolateral Targeting of Sleep Medicine, The Ohio State University Medical Phosphorylation in T567 and Contributes to Its Membrane Proteins in Epithelial Cells. K. Center, Columbus, OH Apical Localization in Intestinal Epithelial Cells. 1 1 1 Kizhatil, H. Li, V. Bennett; Cell Biology, Duke F. A. Wald, A. S. Oriolo, A. Mashukova, N. L. 2086 B437 Downregulation of ABCA1 1 2 1 1 University Medical Center and HHMI, Durham, NC Fregien, A. H. Langshaw, P. J. Salas ; Cell Reduces Oligomerization and Blocks Golgi Exit Biology and Anatomy, University of Miami Miller of Caveolin-1 in Aortic Endothelial Cells. Y. C. 2 School of Medicine, Miami, FL, Pediatrics, Golgi to Cell Surface Transport Lin, V. C. Yang; Department of Life Science, University of Miami Miller School of Medicine, Tunghai University, Taichung, Taiwan Miami, FL 2076 B427 Post-Golgi Trafficking of the 2087 B438 Basolateral Proteins Are Na,K-ATPase. G. A. Farr, M. Hull, M. J. Caplan; 2067 B418 Investigating the Role of Separated into Different Post-Golgi Carriers in Cell. and Mol. Physiology, Yale University School of Phosphoinositide Binding in Merlin Function. T. the Trans-Golgi Network of MDCK Epithelial 1 2 1 1 Medicine, New Haven, CT Mani, J. T. Stickney, W. Ip ; Cell and Cancer Cells. L. N. Nejsum, W. Nelson; Molecular and Biology, College of Medicine, University of 2077 B428 Palmitoylation of ␤1-Adrenergic Cellular Physiology and Biological Sciences, Cincinnati, Cincinnati, OH, 2Regulatory Affairs, The Receptor Is Required for Efficient Trafficking. D. Stanford University Medical School, Stanford, CA Procter & Gamble Company, Cincinnati, OH M. Zuckerman, C. E. Machamer; Cell Biology, 2068 B419 Molecular Perspective of Johns Hopkins University School of Medicine, Endocytosis II Antigen-mediated IgE Receptor Signaling in Baltimore, MD Mast Cells. A. M. Davey,1 K. M. Krise,1 A. A. 2078 B429 Carboxypeptidase E Recruits 2088 B439 Cytoplasmic Provanence of Heikal,2,3 E. D. Sheets1,3; 1Chemistry, The Microtubule Motors to Peptidergic Vesicles for "Activated" STAT3 in the Endolysosomal Pennsylvania State University, University Park, PA, Post-Golgi Trafficking to the Release Site. J. J. Compartment in Pulmonary Arterial Endothelial 2Bioengineering, The Pennsylvania State Park, Y. Loh; Section on Cellular Neurobiology, and Smooth Muscle Cells: Implications in University, University Park, PA, 3The Huck National Institutes of Health, Bethesda, MD Pulmonary Arterial Hypertension. S. Institutes of the Life Sciences, The Pennsylvania Mukhopadhyay,1 P. B. Sehgal1,2; 1Cell Biology and State University, University Park, PA 2079 B430 A Protein Complex Recruited by Anatomy, New York Medical College, Valhalla, NY, the Rhodopsin VxPx Motif Coordinates Ciliary 2 2069 B420 Intermediate Filaments Provide Medicine, New York Medical College, Valhalla, NY Targeting and Cellular Morphogenesis. D. D. a Scaffold to Apically Polarize Microtubule Deretic,1 J. Mazelova,1 L. Astuto-Gribble,1 B. Tam,2 2089 B440 Live-Cell Imaging of Interleukin- Organizing Centers in Simple Epithelial Cells in O. Moritz,2 R. Prekeris,3 P. Randazzo4; 1Surgery/ 6-induced Targeting of Transcription Factor Interphase: A Novel Non-mechanical Function Ophthalmology, University of New Mexico, STAT3 to Sequestering Endosomes in the of Keratins. A. S. Oriolo, F. A. Wald, G. Canessa, Albuquerque, NM, 2Ophthalmology, University of Cytoplasm. F. Xu, S. Mukhopadhyay, P. B. Sehgal; A. Mashukova, P. J. Salas; Cell Biology and British Columbia, Vancouver, BC, Canada, 3Cell Cell Biology & Anatomy, New York Medical Anatomy, University of Miami School of Medicine, and Developmental Biology, University of Colorado, College, Valhalla, NY Miami, FL Aurora, CO, 4Center for Cancer Research, National 2090 B441 Arf6 and Arf1 Interact with the 2070 B421 Cholesterol Controls the Cancer Institute, Bethesda, MD Plasma Membrane t-SNARE Syntaxin 4. C. A. Oligomerization of a Sphingomyelin-specific 2080 B431 Ypt/Rab GTPases and Traffic Eyster, A. Honda, R. Weigert, J. G. Donaldson; Toxin, Lysenin. R. Ishitsuka, T. Kobayashi; RIKEN Coordination. N. Segev, Y. Liang, N. Morozova, A. National Heart Lung and Blood Institute (NHLBI), Discovery Research Institute, Saitama, Japan Tokarev, Z. Lipatova; Biological Sciences, National Institutes of Health (NIH), Bethesda, MD 2071 B422 Basolateral-to-Apical University of Illinois, Chicago, IL 2091 B442 Huntingtin as a Regulator of Transcytosis of GPI-anchored Proteins Is 2081 B432 Finding an In Vivo Role for the Dynein-dependent Endosome Motility. J. P. Dependent on Oligomerization in Polarized Candidate Adaptor Protein Ent4p in Caviston, E. L. F. Holzbaur; Physiology, University Hepatic Cells. R. Galmes, G. Trugnan, M. Saccharomyces cerevisiae. W. K. McCormick, B. of Pennsylvania School of Medicine, Philadelphia, Maurice, T. Aït-Slimane; INSERM, Paris, France R. Wendland; Cell Molecular and Developmental PA 2072 B423 Identification of a Biology, Johns Hopkins University, Baltimore, MD 2092 B443 Adaptor-Endocytic Scaffold , CBP, Responsible for 2082 B433 The Bardet-Biedl Syndrome 3- Interaction Regulates the Spatiotemporal Transiently Anchoring Small Clusters of Thy-1, associated Small GTPase ARL6 Localises to Dynamics of Endocytosis. L. Maldonado-Baez,1 a GPI-anchored Protein, to the Cytoskeleton. Y. Golgi and Basal Bodies and May Regulate E. M. Perkins,2 B. Wendland1; 1Department of Chen,1,2 C. Benistant,3 K. Jacobson2; 1NINDS, Golgi-to-Cilia Protein Trafficking. C. A. Biology, The Johns Hopkins University, Baltimore, National Institutes of Health, Bethesda, MD, 2Cell Schroeder, M. A. Esmail, L. Kang, M. R. Leroux; MD, 2Integrated Imaging Center, The Johns and Developmental Biology, University of North Molecular Biology and Biochemistry, Simon Fraser Hopkins University, Baltimore, MD Carolina, Chapel Hill, NC, 3Universities of University, Burnaby, BC, Canada Montpellier, Montpellier, France 2093 B444 Rab5 Isoforms Differentially Regulate the Trafficking and Signaling of EGFR. P. Chen, C. Kong, X. Su, P. D. Stahl; Cell Biology & Physiology, Washington University Medical School, St. Louis, MO

159 TUESDAY The American Society for Cell Biology 47th Annual Meeting Poster Session 3 B445–B470 December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org

2094 B445 The Interaction of APPL1 with ER to Golgi Transport 2111 B462 Zebrafish bulldog Encodes the Inositol-5-phosphatase OCRL in the Early Sec24D, a Secretory Cargo Adaptor That Is Endocytic Pathway Provides Insights into Lowe Essential for Vesicular Transport of 2103 B454 COPI Is Required for Surface Syndrome. H. J. McCrea,1 K. S. Erdmann,1,2 Y. Extracellular Matrix Proteins in Craniofacial Transport of CFTR. C. D. Tower,1 E. Cormet- Mao,1 R. Zoncu,1 S. Lee,1 S. Paradise,1 J. Chondrocytes. S. Sarmah,1,2 A. B. Gimeno,3 J. Boyaka,2 M. L. Styers,1 E. E. Sztul1; 1Cell Biology, Modregger,1 D. Biemesderfer,3 D. Toomre,4 P. De Topczewski,4 L. Solnica-Krezel,4 E. W. Knapik1,2,3; UAB, Birmingham, AL, 2Division of Pulmonary, Camilli1; 1Department of Cell Biology and Howard 1Department of Medicine, Division of Genetic Critical Care and Sleep Medicine, The Ohio State Hughes Medical Institute, Yale University, New Medicine, Vanderbilt University Medical Center, Univeristy, Columbus, OH Haven, CT, 2Department of Biochemistry II, Ruhr- Nashville, TN, 2Department of Cell and University Bochum, Bochum, Germany, 2104 B455 Diacylglycerol Is Required for Development Biology, Vanderbilt University Medical 3Department of Internal Medicine, Yale University, the Formation of COPI Vesicles in the Golgi-to- Center, Nashville, TN, 3Developmental Biology, New Haven, CT, 4Department of Cell Biology, Yale ER Transport Pathway. I. Fernandez-Ulibarri,1 M. Institute Biology I, University of Freiburg, Freiburg, University, New Haven, CT Vilella,1 F. Lázaro-Diéguez,1 E. Sarri,1 S. Martínez,1 Germany, 4Department of Biological Sciences, N. Jiménez,2 E. Claro,3 I. Mérida,4 K. Burger,5 G. Vanderbilt University Medical Center, Nashville, TN 2095 B446 Imaging the Sorting of Egea1; 1Departamento de Biologia Cellular i Endocytic Cargo in Live Cells. J. Rappoport, S. 2112 B463 Characterization of Arfs at the Anatomia Patològica, Facultat de Medicina, M. Simon; Cellular Biophysics, Rockefeller ERGIC in Live Cells. J. Chun,1 Z. Shapovalova,1 Universitat de Barcelona, Barcelona, Spain, University, New York, NY S. Y. Dejgaard,2 J. F. Presley,2 P. Melancon1; 1Cell 2Cellular Architecture & Dynamics, Science Faculty Biology, University of Alberta, Edmonton, AB, and Institute of Biomembranes, Utrecht University, 2096 B447 Fast Clathrin: A Novel Clathrin Canada, 2Anatomy and Cell Biology, McGill Utrecht, The Netherlands, 3Institut de Coated Membrane Involved in Recycling. Y. University, Montreal, PQ, Canada Zhao, J. H. Keen; Dept. of Biochemistry and Neurociències i Departament de Bioquímica i Molecular Biology and the Kimmel Cancer Center, Biologia Molecular, Facultat de Medicina, UAB, 2113 B464 Diverse Functions of Sec23a 4 Thomas Jefferson University, Philadelphia, PA Bellaterra (Barcelona), Spain, Departamento de and Sec23b in Cargo Selection for ER to Golgi Inmunología y Oncología, Instituto Nacional de Transport. L. A. Beihoffer,1 W. Wang,1 A. M. 2097 B448 Sorting Nexins 1 and 2 Regulate Biotecnología, UAM-CSIC, Madrid, Spain, Krezel,2 E. W. Knapik1,3; 1Genetic Medicine, 5 Lamellipodia Formation and Neurite Outgrowth Biochemical Physiology, Science Faculty and Vanderbilt University, Nashville, TN, 2Department of by the Neuronal RhoG Guanine Nucleotide Institute of Biomembranes, Utrecht University, Biological Sciences, Vanderbilt University, 1,2 Exchange Factor Kalirin-7. D. C. Prosser, J. K. Utrecht, The Netherlands Nashville, TN, 3Department of Cell and 1,2 1 Ngsee ; Department of Neuroscience, University Developmental Biology, Vanderbilt University, 2 2105 B456 The Cargo Receptors Surf4, of Ottawa, Ottawa, ON, Canada, Neuroscience, Nashville, TN Ottawa Health Research Institute, Ottawa, ON, ERGIC-53 and p25 Are Required to Maintain the Canada Architecture of ERGIC and Golgi. S. Mitrovic, H. 2114 B465 STAM Proteins Function in ER- Ben-Tekaya, E. Koegler, H. Hauri; Biozentrum to-Golgi Trafficking through Interactions with 2098 B449 Association with Gb3 Is Not University of Basel, Basel, Switzerland COPII Complexes. N. Rismanchi,1 R. Puertollano,2 Sufficient for Retrograde Traffic of Shiga Toxin C. Blackstone1; 1Cellular Neurology Unit, NINDS, 2106 B457 Arf Nucleotide Exchange from Recycling Endosome to TGN. J. McKenzie, Bethesda, MD, 2Lab of Cell Biology, National Heart, Factors at the Golgi Complex: GBF1 but Not D. R. Sheff; Pharmacology, University of Iowa, Lung, and Blood Institute, Bethesda, MD Iowa City, IA BIGs Is Required for Golgi Assembly and 1 2 1 Function. F. Manolea, A. Claude, J. Chun, J. 2115 B466 Quality Control of MHC I 2 1 1 2099 B450 Synaptogyrin-2: A Putative Rosas, P. Melancon ; Cell Biology, University of Requires Bap31 to Mediate Its Anterograde and 2 Regulator of Membrane Recycling. J. A. Alberta, Edmonton, AB, Canada, Instituto de Retrograde Traffic. N. Van Prooyen, M. Edidin; 1 1,2 1,2,3 Williams, L. A. Lapierre, J. R. Goldenring ; Bioquímica, Universidad Austral de Chile, Valdivia, Biology, Johns Hopkins University, Baltimore, MD 1Surgery, Vanderbilt University Medical Center, Chile Nashville, TN, 2Nashville VA Medical Center, 2116 B467 Regulation of Anterograde Nashville, TN, 3Cell & Developmental Biology, 2107 B458 Identification of a Diacidic ER- Transport of G Protein-coupled Receptors by Vanderbilt University Medical Center, Nashville, TN Export Motif and Potential Protein Chaperones Rab2 and Rab6 GTPases. C. Dong, G. Wu; of a Yeast ABC Transporter, Yor1p. L. Kung, E. Pharmacology, Louisiana State University Health 2100 B451 Rab11-FIPs Interact to Define Miller; Biological Sciences, Columbia University, Sciences Center, New Orleans, LA Distinct Functional Nodes in the Recycling New York, NY System. J. C. Schafer,1 L. A. Lapierre,1 A. K. 2117 B468 Cytosolic PLA2a Regulates Kenworthy,2 J. R. Goldenring1; 1Surgery, Vanderbilt 2108 B459 Role of Got1p in ER-Golgi Progression of Cargo through the Golgi Stack 1 University, Nashville, TN, 2Molecular Physiology & Trafficking in Yeast. A. Lorente Rodríguez, M. via Formation of Tubular Connections between 2 1 1 Biophysics, Vanderbilt University, Nashville, TN Heidtman, C. Barlowe ; Biochemistry, Dartmouth Neighboring Cisternae. E. San Pietro, E. V. 2 Medical School, Hanover, NH, Microbiology, Tufts Polishchuk, A. Di Pentima, A. Trucco, P. Zizza, S. 2101 B452 Megalin/LRP2 Phosphorylation University School of Medicine, Boston, MA Mariggio, A. A. Mironov, A. Luini, R. S. Polishchuk; and GSK3 Activity Regulate the Receptor Department of Cell Biology and Oncology, 1 2109 B460 Activation of the Unfolded Recycling and Cell Surface Levels. P. Farfán, Consorzio Mario Negri Sud, Santa Maria Imbaro 1 2 1 1 Protein Response Pathway Does Not Rescue M. Yuseff, G. Bu, M. Marzolo ; Departamento de (CH), Italy Biología Celular y Molecular, Pontificia Universidad the Folding and Export from the Endoplasmic Católica de Chile, Santiago, Chile, 2Washington Reticulum of Misfolded Yeast Proteins. M. 2118 B469 Maintaining Fidelity of ER University School of Medicine, St. Louis, St. Louis, Dorrington, E. A. Miller; Biological Sciences, Export: A Genome-wide Screen for Yeast ER MO Columbia University, New York, NY Retention Mutants Identifies a Novel Role for a Chromatin Remodeling Complex. S. Pagant, A. 2102 B453 Internalization of Plasma 2110 B461 Sec16 Is a Multi-Domain Protein 1 Copic, J. Barry, E. Miller; Biological Sciences, Membrane Calcium ATPase (PMCA) during That Organizes Discrete tER Sites. Y. Liu, M. 2 1 1 Columbia University, New York, NY Xenopus Oocyte Meiotic Maturation. W. El-Jouni, Esaki, B. Glick ; MGCB, University of Chicago, 2 S. Haun, K. Machaca; Physiology and Biophysics, Chicago, IL, Institute of Molecular Embryology and 2119 B470 Effect of Mutation I541F of the University of Arkansas for Medical Sciences, Little Genetics, Kumamoto University, Kumamoto, Japan MDR3 Gene Associated with Progressive Rock, AR Familial Intrahepatic Cholestasis Type III. A. Durand-Schneider,1 D. Delautier,1 J. Gabillet,1 T. Aït Slimane,1 J. Delaunay,1 G. Trugnan,1 E. Jacquemin,2 M. Maurice1; 1U538, INSERM, Paris, France, 2Pediatric Hepatology, Bicetre Hospital, Bicetre, France

160 The American Society for Cell Biology 47th Annual Meeting TUESDAY December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org Poster Session 3 B471–B493

2120 B471 A Legionella pneumophila 2126 B477 Signal-dependent Transport of 2135 B486 Investigating the Biochemical Ankyrin Repeat Protein That Interferes with Basolateral Proteins between TGN and Properties of MAL and MAL2 in Polarized WIF-B Vesicular Transport in Mammalian Cells. X. Recycling Endosomes. J. Cancino,1 C. Cells. S. Ramnarayanan, J. G. In, P. L. Tuma; Pan,1 A. Satoh,2 G. Warren,2 C. R. Roy1; 1Section Torrealba,1 A. Soza,1 P. Henklein,2 E. Rodriguez- Biology, The Catholic University of America, of Microbial Pathogenesis, Yale University, New Boulan,3 A. González1; 1Inmunología Clínica y Washington, DC Haven, CT, 2Cell Biology, Yale University, New Reumatología, Fac. Medicina and Centro de Haven, CT Regulación Celular y Patología, Fac. Ciencias Biológicas. P. Universidad Católica de Chile, Protein Targeting to the Cell Surface 2121 B472 Interaction of Drosophila Rab Santiago, Chile, 2Institute of Biochemistry, Faculty GDI with Gint3, a UBX-Domain-containing of Medicine, Humboldt University, Berlin, Germany, 2136 B487 Secretory Carrier Membrane 1 1 1 Protein. P. Amin, S. A. Li, C. Y. Cheng, R. 3Dyson Vision Research Institute, Weill Medical Proteins Regulate the Cell-Surface Abundance 2 1 1 Rawle, A. Y. W. Chen, B. E. Richardson, M. College, Cornell University, New York, NY of Na+/H+ Exchanger NHE5. G. H. Diering, J. Johal,2 C. M. Cheney1; 1Biology, Pomona College, Church, M. Numata; Biochemistry and Molecular Claremont, CA, 2Chemistry, Pomona College, 2127 B478 FRET-based Assays Show Biology, University of British Columbia, Vancouver, Claremont, CA Distinct Receptor-Ligand Interactions and BC, Canada Organization during Endocytic Trafficking. H. Wallrabe,1 G. Bonamy,2 R. Talati,3 M. Barroso3; 2137 B488 Knockout of the F-BAR Protein Trafficking in Polarized Cells 1W. M. Keck Center for Cellular Imaging, CIP4 Enhances Glucose Tolerance through Department of Biology, University of Virginia, Dysregulation of GLUT4 Trafficking. S. M. 2122 B473 Mapping Out the Itinerary and Charlottesville, VA, 2Department of Functional Hartig,1 E. G. Blanchard,1 Y. Feng,1 E. G. Caudell,1 Binding Interactions of MAL2 in Polarized Genomics, Genomic Institute of the Novartis C. S. Pichot,1 K. A. Voekler,2 R. W. Grange,2 S. Hepatic Cells. J. G. In, S. P. Ramnarayanan, P. L. Research Foundation, San Diego, CA, 3Center for Ishikura,3 S. J. Corey1; 1Pediatrics, University of Tuma; Biology, The Catholic University of America, Cardiovascular Sciences, Albany Medical Center, Texas MD Anderson Cancer Center, Houston, TX, Washington, DC Albany, NY 2Human Nutrition, Foods and Exercise, Virginia Polytechnic Institute and State University, 2123 B474 Requirement for Galectin-3 in 2128 B479 Axonal Retrograde Transport of Blacksburg, VA, 3Cell Biology Programme, The 1 1 Apical Trafficking. D. Delacour, A. Koch, A. Le Neurotrophins and Signalling Molecules: on the Hospital for Sick Children, Toronto, ON, Canada Bivic,2 H. Leffler,3 F. Poirier,4 R. Jacob1; 1Cell Role of the Endocytic Proteins Rab5 and Rab7. Biology Department, Philipps University of Marburg, S. Salinas, G. Menendez, K. Deinhardt, C. 2138 B489 Diffusion and Exchange Kinetics Marburg, Germany, 2CNRS-UMR 6156, Institute of Verastegui, G. Schiavo; Molecular of Prenylated and Acylated Forms of Ras2 in Developmental Biology of Marseille, Marseille, NeuroPathobiology, Cancer Research UK–London Saccharomyces cerevisiae Using Fluorescence France, 3Lund University, Section of Microbiology Research Institute, London, United Kingdom Recovery after Photobleaching. K. C. Vinnakota,1 Immunology and Glycobiology (MIG), Lund, D. A. Mitchell,2 T. Wakatsuki,1,3 D. A. Beard,1,3 R. Sweden, 4Development Department, Institute 2129 B480 Rab13 Regulates Membrane J. Deschenes2; 1Biotechnology and Bioengineering Jacques Monod, Paris, France Trafficking between the trans-Golgi Network Center, Medical College of Wisconsin, Milwaukee, and Recycling Endosomes. R. Nokes,1 I. Fields,1 WI, 2Biochemistry, Medical College of Wisconsin, 2124 B475 The Rab8 GTPase Regulates R. Collins,2 H. Fölsch1; 1Department of Milwaukee, WI, 3Physiology, Medical College of Apical Protein Localisation in Intestinal Cells. T. Biochemistry, Molecular Biology & Cell Biology, Wisconsin, Milwaukee, WI Sato,1 S. Mushiake,2 Y. Kato,3 K. Sato,1 M. Sato,1 Northwestern University, Evanston, IL, 2Department N. Takeda,4 K. Ozono,2 K. Miki,5 Y. Kubo,3 A. of Molecular Medicine, Veterinary Medical College, 2139 B490 Src Kinase Activity and SH2 Tsuji,3 R. Harada,1 A. Harada1; 1Department of Cornell University, Ithaca, NY Domain Binding Regulate the Dynamics of Molecular and Cellullar Biology, Institute for Activation-dependent Association of Src with Molecular and Cellular Regulation, Maebashi, 2130 B481 Novel Protein Kinases Fpk1p Lipid and Protein Targets. D. E. Shvartsman,1 J. Gunma, Japan, 2Department of Pediatrics, Osaka and Fpk2p Regulate Membrane Phospholipid C. Donaldson,2 B. Diaz,2 O. Gutman,1 G. S. University Graduate School of Medicine, Osaka, Asymmetry via the Putative Flippases Dnf1p Martin,2 Y. I. Henis1; 1Neurobiochemistry, Tel Aviv Japan, 3Division of Pharmaceutical Sciences, and Dnf2p. K. Nakano,1 T. Yamamoto,2 T. University, Tel Aviv, Israel, 2Molecular and Cell Graduate School of Natural Science and Kishimoto,1 T. Noji,1 K. Tanaka2; 1Hokkaido Biology, University of California at Berkeley, Technology, Kanazawa University, Kanazawa, University Graduate School of Medicine, Institute Berkeley, CA Japan, 4Division of Transgenic Technology, for Genetic Medicine, Sapporo, Japan, 2Hokkaido Kumamoto University, Kumamoto, Japan, University Graduate School of Life Science, 2140 B491 Protein Phosphatase Type 1 5Department of Pediatrics, Itami Municipal Hospital, Institute for Genetic Medicine, Sapporo, Japan Recruitment to the Bud Neck in S. cerevisiae Is Hyogo, Japan Necessary and Sufficient for Localized Chitin 2131 B482 Regulation of the Localisation Deposition. J. R. Larson, K. Tatchell; Biochemistry 2125 B476 Exocyst Is Required for of the hScribble Cell Polarity Complex. N. and Molecular Biology, Louisiana State University Endocytic Traffic Directed Toward the Apical Narayan, N. Gammoh, P. Massimi, M. Thomas, L. Health Sciences Center, Shreveport, LA and Basolateral Poles of Polarized MDCK Cells. Banks; ICGEB, Trieste, Italy A. Oztan,1 M. Silvis,2 O. Weisz,1 N. Bradbury,3 S. 2141 B492 Mechanisms of Plasma 2132 B483 Phosphatidylinositol 3- Hsu,4 J. Goldenring,5 C. Yeaman,6 G. Apodaca1; Membrane Remodeling during Cellularization phosphate and FYVE Domain Protein SARA 1Department of Medicine, University of Pittsburgh, and Cell Division. A. Audhya, R. Green, K. Regulate the Vesicular Targeting of Rhodopsin Pittsburgh, PA, 2Department of Cell Biology & Oegema; Department of Cellular and Molecular and Light Sensing Organelle Formation in Physiology, University of Pittsburgh, Pittsburgh, PA, Medicine, Ludwig Institute for Cancer Research, La Mammalian Rods. J. Chuang, Y. Zhao, C. Sung; 3Department of Physiology and Biophysics, Jolla, CA Ophthalmology/Cell & Developmental Biology, Weill Chicago Medical School, Chicago, IL, 4Department Medical College of Cornell University, New York, 2142 B493 Characterization of a Vesicle of Cell Biology and Neuroscience, Rutgers NY Recognition Domain within Naked2. C. Li, Z. University, Piscataway, NJ, 5Department of Surgery Cao, W. Ding, T. Hu, T. Van Raay, R. Graves-Deal, and Cell & Developmental Biology, Vanderbilt 2133 B484 A Biological Function for the J. Smith, R. Coffey; Departments of Medicine, and University, Nashville, TN, 6Department of Anatomy Notch Ligand Delta That Is targeted to Cell and Developmental Biology, Vanderbilt and Cell Biology, University of Iowa, Iowa City, IA Secretory Exosomes? S. Monier, R. Le Borgne; University Medical Center and Department of Institut de Genetique et Developpement, CNRS Veterans Affairs Medical Center, Nashville, TN UMR 6061–Universite de Rennes 1, Rennes cedex, France

2134 B485 Polarized Trafficking of Fibroblast Growth Factor Receptor (FGFR) to the Basal Membrane during Inner Ear Development. A. Honda, X. Sai, R. K. Ladher; RIKEN Center for Developmental Biology, Kobe, Japan

161 TUESDAY The American Society for Cell Biology 47th Annual Meeting Poster Session 3 B494–B526 December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org

2143 B494 Non-classical Transport 2153 B505 The OGF-OGFr Axis Targets 2164 B516 Two Distinct Ubiquitin E3 Ligase Pathway for Soluble Proteins in Dictyostelium: Cyclin-dependent Kinase Inhibitory Pathways in Systems Degrade p27 in Corneal Endothelial I. Docking of the Soluble Cell Adhesion Human Epidermal Keratinocytes. I. S. Zagon,1 F. Cells. J. Lee,1 E. P. Kay1,2; 1Doheny Eye Institute, Molecule DdCAD-1 onto Contractile Vacuoles Cheng,1 M. F. Verderame,2 P. J. McLaughlin1; Los Angeles, CA, 2Ophthalmology, Keck School of Requires Calmodulin. I. V. Ivanov, S. 1Neural and Behavioral Sciences, Penn State Medicine of University of Southern California, Los Sriskanthadevan, S. Brar, C. Chi-Hung Siu; Banting University, Hershey, PA, 2Medicine, Penn State Angeles, CA and Best Department of Medical Research and University, Hershey, PA Department of Biochemistry, University of Toronto, 2165 B517 Differential Regulation of Cullin3 Toronto, ON, Canada 2154 B506 Hip-2, Huntingtin Interacting by Ubiquitin Conjugating Enzymes. K. S. Plafker, Protein 2, Might Play a Role as Cell Cycle S. M. Plafker; Cell Biology, University of Oklahoma 2144 B495 Non-Classical Transport Regulator. Y. Bae, D. Choi, S. Kang; Korea Health Sciences Center, Oklahoma City, OK Pathway for Soluble Proteins in Dictyostelium: University, Seoul, Republic of Korea II. Involvement of V-H(+)-ATPase in the 2166 B518 INF Gamma-inducible Translocation of DdCAD-1 across the 2155 B507 Characterization of S Phase- Lysosomal Thiol Reductase Affects the Contractile Vacuole Membrane. I. V. Ivanov, S. specific Repression of Id-1 Protein in HeLa Cell. Expression and Function of SOD2 in Mouse 1 1 2 1 1 Sriskanthadevan, C. Siu; Banting and Best E. Yun, K. Song, H. Park, J. Kim, J. Park, J. Fibroblasts. B. Bogunovic, M. Maric; Microbiology 1 1 1 1,3 1,3 Department of Medical Research and Department Heo, K. Jing, Y. Jung, J. Park, G. Kweon, and Immunology, Georgetown University, 1,3 1 1,3 1,4 of Biochemistry, University of Toronto, Toronto, ON, S. Park, W. Yoon, B. Hwang, K. Lim ; Washington, DC 1 Canada Department of Biochemistry, College of Medicine, Chungnam National University, Daejeon, Republic 2167 B519 A New Anti-Aging Approach: 2145 B496 Non-Classical Transport of Korea, 2Dr. Park’s Breast Clinic, Daejeon, Modulating Cytochrome C Cellular Level, and Pathway for Soluble Proteins in Dictyostelium: Republic of Korea, 3Research Institute of Medical Enhancing Mitochondrial Membrane Potential. I. III. Involvement of Multiple Protein Binding Science, Chungnam National University, Daejeon, Imbert, E. Bauza, C. Dal Farra, N. Domloge; Skin Sites in the C-terminal Domain of DdCAD-1. S. Republic of Korea, 4Cancer Research Institute, Research Center, Vincience, ISP, Sophia Antipolis, Sriskanthadevan, I. Ivanov, C. Siu; Banting and Chungnam National University, Daejeon, Republic France Best Department of Medical Research and of Korea Department of Biochemistry, University of Toronto, Oncogenes and Tumor Suppressors II Toronto, ON, Canada 2156 B508 Investigation of the Relationship between Pin1 Function and Isomerase Activity. 2146 B497 Maturation and Targeting of M. L. Bailey, E. L. Parker, C. J. Brandl, B. H. 2168 B520 RASSF1A Inhibition of Extracellular Hydrogen Peroxide Generators, Shilton, D. W. Litchfield; Biochemistry, University of Transcription in U2OS Cells. J. L. Sullivan,1 S. Duox1 and Duox2. S. C. Morand, T. L. Leto; LHD, Western Ontario, London, ON, Canada Baksh,2 J. C. Pratt1; 1Olin College, Needham, MA, NIH, NIAID, Rockville, MD 2Pediatrics, University of Edmonton, Edmonton, 2157 B509 The Activity of the Budding AB, Canada Yeast G1 Cyclin Cln3 in the Absence of NUP84. Cell Cycle Controls II T. C. Cullender, M. E. Miller; Biology, Rhodes 2169 B521 Functional Interaction of College, Memphis, TN RASSF1A and Grb2 with TNFR1. K. Levi,1 S. 2 1 1 2147 B499 Downregulation of Notch Baksh, J. C. Pratt ; Olin College, Needham, MA, 2158 B510 Impairment of G1 Cyclin Cln3 2 Signaling Is Required for Tramtrack-induced Pediatrics, University of Alberta, Edmonton, AB, Dependent Viability in the Absence of KAP114 Cell-Cycle Exit. J. Sun, W. Deng; Department of Canada and QUE1in the Budding Yeast Saccharomyces Biological Science, Florida State University, cerevisiae. S. E. Mercer, M. E. Miller; Biology, 2170 B522 Understanding the Molecular Tallahassee, FL Rhodes College, Memphis, TN Basis for PDZ Domain Binding Specificity. M. 2148 B500 A Quantitative Study of the Role Thomas, P. Massimi, L. Banks; Tumour Virology 2159 B511 The Role of the APC/C and Clp1 of Cdc25A in Cell Cycle Remodeling and Lab, ICGEB, Trieste, Italy in the Inactivation and Degradation of Cdc25 in Checkpoints in Xenopus laevis Embryos. N. Schizosaccharomyces pombe. C. D. Davis, B. A. 2171 B523 The Nuclear RhoA-exchange Adjerid, J. Zwolak, J. Sible, J. Tyson; Virginia Tech, Wolfe, K. L. Gould; Cell and Developmental Factor Net1 Interacts with Proteins of the Dlg Blacksburg, VA Biology, Vanderbilt Unversity School of Medicine Family, Affects Their Localization and 2149 B501 Inducible Expression of CK2 and HHMI, Nashville, TN Influences Their Tumor Suppressor Activity. R. 1 1 1 Phosphorylation Site Mutants Reveals a Role Garcia-Mata, A. D. Dubash, L. Sharek, H. S. 2160 B512 The Phospholipase B Homolog, 2 2 1 1 for CK2 Phosphorylation in Mitosis. N. A. St- Carr, J. A. Frost, K. Burridge ; Cell and Plb1, and the cAMP/Protein Kinase A Pathway Denis, D. R. Derksen, D. W. Litchfield; Developmental Biology, University of North Function Coordinately to Regulate an Osmotic 2 Biochemistry, University of Western Ontario, Carolina–Chapel Hill, Chapel Hill, NC, Integrative Stress-induced Growth Control System in the London, ON, Canada Biology and Pharmacology, University of Texas Fission Yeast, Schizosaccharomyces pombe. Y. Health Science Center, Houston, TX 2150 B502 ATM-related Checkpoint Kinase Matsuo, M. E. Perenlei, B. McInnis, S. Marcus; Modulates Gene Expression at the Onset of S- Biological Sciences, The University of Alabama, 2172 B524 Epidermal Hyperplasia and phase Arrest in Fission Yeast. Z. Chu, J. Li, M. Tuscaloosa, AL Papillomatosis in Mice with a Keratinocyte- Eshaghi, K. Karuturi, J. Liu; Genome Institute of restricted Deletion of csk. T. Sakaguchi, K. 2161 B513 Cdh1 Is Required for Stress Singapore, Singapore Honda, K. Sakai, T. Sakai; Biomedical Engineering, Response in S. cerevisiae. J. Simpson, M. The Cleveland Clinic, Cleveland, OH 2151 B503 Directionality of Cell Cycle Brandeis; Genetics, Hebrew University, Jerusalem, Transitions in Mitosis. T. A. Potapova, G. J. Israel 2173 B525 Disconnecting Oligomerization Gorbsky; Molecular, Cell and Developmental from Kinase Activity: An In Vivo Analysis of c- 2162 B514 Identification and Boilogy, University of Oklahoma Health Sciences Fes Protein-tyrosine Kinase Oligomerization. J. Characterization of Fbw7 Isoform Specific Center, Oklahoma City, OK M. Shaffer, T. E. Smithgall; Molecular Genetics & Interacting Proteins. W. Zhang, E. M. MacDonald, Biochemistry, University of Pittsburgh, Pittsburgh, 2152 B504 Hepatocyte Growth Factor D. M. Koepp; Genetics, Cell Biology and PA Induces Cell Cycle Withdrawal in Satellite Cells Development, University of Mnnesota, in a MAPK-dependent Manner. J. Li, S. A. Reed, Minnneapolis, MN 2174 B526 Overexpression of Titin Z1Z2Zr S. E. Johnson; Animal Sciences, University of Domains in MG63 Stimulates Cell Growth by 2163 B515 De-regulation of Cell Cycle 1 Florida, Gainesville, FL Activating WNT/beta-Catenin Pathway. J. Qi, L. Progression by a Viral Mimic of Anaphase Chi,1 A. Banes1,2; 1Flexcell International Promoting Complex Subunit 11. M. Mo, E. Corporation, Hillsborough, NC, 2Joint Department Whelan, S. B. Fleming, A. A. Mercer; Microbiology, of Biomedical Engineering, University of North Otago University, Dunedin, New Zealand Carolina, North Carolina State University, Raleigh, NC

162 The American Society for Cell Biology 47th Annual Meeting TUESDAY December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org Poster Session 3 B527–B554

2175 B527 Inhibitory Effect of Naturally 2186 B538 Investigation of the Mechanism 2195 B547 Preformed Homo- and Source Compounds on Human Cancer Lung, Underlying the Anti-Mitogenic Activity of Heterodimers between Four Members of the Prostate, and Breast Cell Growth. H. Tokuda,1 A. Suramin. K. Ibrahim, K. M. Kathir, S. Kumar; ErbB Receptor Family. R. Tao, I. Maruyama; Iida2; 1Molecular Biochemistry, Kyoto Prefectural Chemistry and Biochemistry, University of Okinawa Institute of Science and Technology, University of Medicine, Kyoto, Japan, 2Takasaki Arkansas, Fayetteville, AR Okinawa, Japan University of Welfare and Health, Takasaki, Japan 2187 B539 Repercussions of Silencing the 2196 B548 RAGE Signaling in Myoblasts 2176 B528 Recombinant Human MIS Opioid Growth Factor Receptor (OGFr) in and Rhabdomyosarcoma Cells Causes Represses Malignant Ovarian Cancer. H. Kim,1 Human Cancer Cells. P. J. McLaughlin,1 R. N. Downregulation of Pax7 Expression via p38 D. Roh,1 J. Byun,1 T. Jo,1 J. Lee,1 Y. Kim,1 S. Do,2 Donahue,1 M. F. Verderame,2 I. S. Zagon1; 1Neural MAPK Activation and Upregulation of Myogenin Y. Hwang,1 D. Kim1; 1Division of Biological and Behavioral Sciences, Penn State University, Expression. G. Sorci,1 F. Riuzzi,1 R. Alaggio,2 A. Science, Gachon University of Medicine and Hershey, PA, 2Medicine, Penn State University, Sidoni,1 V. Ninfo,2 R. Donato1; 1Department of Science, Incheon, Republic of Korea, 2Clinical Hershey, PA Experimental Medicine & Biochemical Science, Pathology, College of Veterinary Medicine, Konkuk University of Perugia, Perugia, Italy, 2Department of University, Seoul, Republic of Korea 2188 B540 Nucleocytoplasmic Trafficking Diagnostic Medicine, University of Padova, Padova, of the Opioid Growth Factor Receptor (OGFr). F. Italy 2177 B529 Induction of S100P by Non- Cheng,1 M. F. Verderame,2 P. J. McLaughlin,1 I. S. steroidal Anti-Inflammatory Drugs. T. Homan, N. Zagon1; 1Neural and Behavioral Sciences, Penn 2197 B549 S100A11, an Ambivalent Tomoko, T. Mizushima; Kumamoto University, State University, Hershey, PA, 2Medicine, Penn Mediator for Growth Regulation of Human Kumamoto, Japan State University, Hershey, PA Keratinocytes. M. Sakaguchi,1 H. Sonegawa,1 H. Murata,1 M. Kitazoe,2 J. Futami,2 K. Kataoka,1 H. 2178 B530 Inhibition of Telomerase Activity 2189 B541 Aberrant PDGFR Ubiquitination Yamada,2 N. Huh1; 1Cell Biology, Okayama and Tumor Cell Proliferation by Bone and Trafficking Is Oncogenic in Cells University Graduate School of Medicine and Morphogenetic Protein-7. L. Cassar, H. Li, A. Expressing a Mutant PI3K (p85R274A) Defective Dentistry, Okayama, Japan, 2Bioscience and 1,2 Pinto, J. Liu; Immunology, Monash University, for RabGAP Activity. J. C. Oberg, M. D. Biotechnology, Okayama University Graduate 1 1 1 Melbourne, Australia Chamberlain, S. F. Poland, A. D. Hawrysh, D. H. School of Natural Science and Technology, 1 1 Anderson ; Cancer Research Unit, Saskatchewan Okayama, Japan 2179 B531 Hippo Signaling Pathway in Cancer Agency, Saskatoon, SK, Canada, Mammals Targets YAP and Regulates Its Pro- 2Department of Biochemistry, University of 2198 B550 Decreased Expression of 1 1 apoptotic Function. T. Oka, V. Mazack, M. Saskatchewan, Saskatoon, SK, Canada Vascular Endothelial Growth Factor (VEGF) as a 1,2 1 Sudol ; Weis Center for Research, Danville, PA, Survival Factor Is Involved in Abnormal 2 Department of Medicine, Mount Sinai School of 2190 B542 Altered PDGF Receptor Placentation. H. Lee,1 J. Song,1 M. Baik,1 R. Medicine, New York, NY Phosphorylation, Trafficking, and Degradation Romero,2 C. Kim,2 G. Kim3; 1Chabiotech Co., Ltd., Result in Oncogenisis with the Expression of a Seoul, Republic of Korea, 2National Institute of 1 p85 (PI3K) RabGAP Mutant. P. H. Links, M. D. Child Health and Human Development/National Growth Factors and Receptors 2 1 1 Chamberlain, J. M. Kristy, A. D. Hawrysh, T. Institutes of Health/Department of Perinatology 3 3 3 1 Chan, A. Saxena, J. Xiang, D. H. Anderson ; Research Branch, Bethesda, MD, 3Pochon CHA 2180 B532 EGF Enhances Aurora-A 1 Saskatchewan Cancer Unit, Saskatchewan University, Seoul, Republic of Korea Expression by Translational Regulation through Cancer Agency, Saskatoon, SK, Canada, the Akt and ERK Pathway in Human Colorectal 2Department of Biochemistry, University of 2199 B551 Betaglycan Releases a Stable Cancer Cells. L. Hung1,2; 1Department of Saskatchewan, SK, Canada, 3Department of Transmembrane/Cytoplasmic Fragment That Is Pharmacology, Tainan, Taiwan, 2National Cheng Pathology, University of Saskatchewan, SK, a Substrate for ␥-Secretase. C. Blair,1 R. G. Kung University, Tainan, Taiwan Canada Wells2; 1University of Pennsylvania, Philadelphia, PA, 2GI, University of Pennsylvania, Philadelphia, 2181 B533 ERK1/2 Mediate Wounding- and 2191 B543 PTEN Mediated Deactivation of PA GPCR Ligands-induced EGFR Transactivation PI3K Signaling is Coordinated by Specific in Corneal Epithelial Cells. J. Yin, F. Yu; Anatomy MAGI-2 Domains. S. F. Poland, P. H. Links, L. A. 2200 B552 Genetic Analysis of Wireless, a and Cell Biology, Wayne State University, Detroit, Furber, S. M. Knafelc, K. M. James, A. D. Novel ENU-induced Mutation That Disrupts MI Hawrysh, D. H. Anderson; Cancer Reserch Unit, Neural Crest Development. K. Buac,1,2 D. Saskatchewan Cancer Agency, University of Watkins-Chow,1 M. Jones,3 E. Escobar,4 W. 2182 B534 Knockdown of rab7 Causes Saskatchewan, Saskatoon, SK, Canada Pavan1; 1NHGRI, Bethesda, MD, 2The George Endosomal Accumulation of Activated EGFRs. Washington University, Washington, DC, P. A. Vanlandingham, B. P. Ceresa; Department of 2192 B544 Structure-Function Analysis of 3Genomics Core, NHGRI, Bethesda, MD, 1,2 1,2 Cell Biology, University of Oklahoma Health PTEN Mutants. S. M. Knafelc, M. C. Pastor, 4Transgenic Mouse Core, NHGRI, Bethesda, MD Sciences Center, Oklahoma City, OK D. H. Anderson1; 1Cancer Research Unit, Saskatchewan Cancer Agency, Saskatoon, SK, 2201 B553 GRP94 Is Critical for Terminal 2183 B535 Understanding the Mechanism Canada, 2Department of Biochemistry, University of Muscle Differentiation Because It Regulates of Fibroblast Growth Factor (FGF) Signaling. B. Saskatchewan, Saskatoon, SK, Canada Secretion of Insulin-like Growth Factor-II. O. A. Blough, D. Rajalingam, T. Kumar; Chemistry and Ostrovsky,1 S. Wanderling,2 B. B. Simen,2 Y. Biochemistry, University of Arkansas, Fayetteville, 2193 B545 Myosin II-A Motor Activity Argon1; 1Division of Cell Pathology, Children's AR Regulates the Exocytosis of Tumor Necrosis Hospital of Philadelphia, and the University of 1 Factor (TNF) Receptor -1 (TNFR-1). J. Chen, P. Pennsylvania, Philadelphia, PA, 2Department of 2184 B536 Expression of FGFs and FGFRs 2 1 1 J. Gallager, Y. Jin ; Molecular and Cellular Pathology, The University of Chicago, Chicago, IL in Human Hepatocellular Carcinoma Cell Lines. Physiology, Louisiana State University Health J. Namkung, J. Yoon, J. Sohn, M. Woo, B. Yeh; Science Center, Shreveport, LA, 2Cellular and 2202 B554 Gfra1 Silencing in Mouse Department of Biochemistry, Wonju College of Integrative Physiology, Indiana University School of Spermatogonial Stem Cells Results in Their Medicine, Yonsei University, Wonju, Republic of Medicine, Indianapolis, IN Differentiation via the Inactivation of RET Korea Tyrosine Kinase. Z. He,1 J. Jiang,1 M. Hofmann,2 2194 B546 Hepatic Overexpression of 1 1 2185 B537 Characterization of Distinct M. Dym ; Biochemistry and Molecular & Cellular Connective Tissue Growth Factor Abrogates Biology, Georgetown University Medical Center, Roles of FGFR1 and FGFR2 in Breast Cancer. 1 Fibrosis-Resistance in the Liver. R. Chen, Z. 2 1 L. Pappas,1 J. Rosen,2 J. Brugge1; 1Cell Washington, DC, Veterinary Biosciences, W. Xian, Tong,1 S. Kemper,1 A. Rachfal,1 D. Ball,1 B. Biology, Harvard Medical School, Boston, MA, University of Illinois, Urbana, IL Perbal,2 D. R. Brigstock1; 1Cell & Vascular Biology, 2Molecular and Cellular Biology, Baylor College of Children's Research Institute, Columbus, OH, 2UFR Medicine, Houston, TX de Biochimie, Université Paris, Paris, France

163 TUESDAY The American Society for Cell Biology 47th Annual Meeting Poster Session 3 B555–B582 December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org

2203 B555 Decreased Expression of IL-2 2211 B563 Are Anti-Apoptotic Bcl-2 Family 2221 B573 Effects of the Small Molecule Receptor (CD25) in Rat Heart Allografts with Proteins Involved in Cell Division? S. C. Inhibitors ZM447439 and VX-680 on Intracellular Concomitant Vascularized Bone Marrow Beishir,1 C. Xing,2 R. Kuriyama1; 1Genetics, Cell Biomarkers of Aurora Kinase Activity. R. K. Transplantation (VBMT). S. A. Kopp,1 L. F. Biology, and Development, University of Minnesota, Tyler, P. A. Eyers; Faculty of Life Sciences, Strande,2 D. R. Lefebvre,2 M. S. Matthews,2 S. W. Minneapolis, MN, 2Medicinal Chemistry, University University of Manchester, Manchester, United Marra,2 C. W. Hewitt2; 1Surgery, UMDNJ–Robert of Minnesota, Minneapolis, MN Kingdom Wood Johnson Medical School, Camden, NJ, 2Surgery, Cooper University Hospital/ 2212 B564 Factors That Regulate Caspase- 2222 B574 Dictyostelium Aurora Has the 1 UMDNJ–Robert Wood Johnson Medical School, independent Mitotic Death (CIMD). Y. Niikura, A. Properties of Aurora A and B Kinases, and 2 2 2 1 Camden, NJ Dixit, R. Scott, G. Perkins, K. Kitagawa ; Requires DdINCENP and Kif12 for Localization 1Molecular Pharmacology, St. Jude Children's to the Central Spindle but Not to Spindle Poles Research Hospital, Memphis, TN, 2National Center or Centromeres. H. Li, Q. Chen, A. De Lozanne; Mitosis and Meiosis III for Microscopy and Imaging Research, Center for Molecular Cell & Developmental Biology, University Research on Biological Structure, School of of Texas at Austin, Austin, TX 2204 B556 Requirement for Protein Medicine, University of California, San Diego, La 2223 B575 Positive Feedback between the Phosphatase 1 Downstream from Cdk1/Cyclin B Jolla, CA Chromosomal Passenger Complex and Inactivation during Exit from Mitosis in 2213 B565 Mitotic Chromosome Microtubules. B. Tseng, A. E. Kelly, H. Funabiki; Saccharomyces cerevisiae. J. M. Keaton, B. G. Biorientation in Fission Yeast Is Enhanced by Chromosome and Cell Biology, The Rockefeller Workman, L. Xie, J. R. Paulson; Chemistry, Dynein and a Minus-End-directed, Kinesin-like University, New York, NY University of Wisconsin–Oshkosh, Oshkosh, WI Protein. E. L. Grishchuk,1,2 I. S. Spiridonov,1,3 J. 1 1 2224 B576 The Role of Mast and Dynein in 2205 B557 Multiple Protein Phosphatases R. McIntosh ; MCD Biology, University of 2 the Establishment of the Bipolar Mitotic Are Required for Mitosis in Drosophila. F. Colorado, Boulder, CO, Institute of General Spindle. R. Reis,1 C. E. Sunkel1,2; 1Molecular Chen,1 V. Archambault,1 A. Kar,1 P. Lio,2 P. Pathology and Pathophysiology, Moscow, Russian 3 Genetics, Institute for Molecular and Cell Biology, D'Avino,1 R. Sinka,3 K. Lilley,4 E. D. Laue,4 P. Federation, National Research Center for Porto, Portugal, 2Instituto de Ciências Biomédicas Deak,5 L. Capalbo,1 D. M. Glover1; 1Genetics, Hematology, Moscow, Russian Federation de Abel Salazar, Universidade do Porto, Porto, University of Cambridge, Cambridge, United 2214 B566 The Kinesin-13 Protein, Kif2b, Portugal Kingdom, 2The Computer Laboratory, University of Contributes to the Fidelity of Chromosome Cambridge, Cambridge, United Kingdom, 3MRC Segregation in Human Cells. S. F. Bakhoum, D. 2225 B577 Defects in Centrosomes and Laboratory of Molecular Biology, University of A. Compton; Biochemistry, Dartmouth Medical Chromosome Segregation from Depletion of Cambridge, Cambridge, United Kingdom, Phosphatase Inhibitor-2 in Human ARPE19 4 School, Hanover, NH Biochemistry, University of Cambridge, Epithelial Cells. W. Wang,1 P. T. Stukenberg,2 D. 5 Cambridge, United Kingdom, Institute of 2215 B567 Kinesin 5 Is Not Required for L. Brautigan1; 1Center for Cell Signaling, University Biochemistry, Biological Research Center, Szeged, Cell Division in Dictyostelium. M. Koonce, D. K. of Virginia, School of Medicine, Charlottesville, VA, Hungary Nag, N. Martin, I. Tikhonenko; Molecular Medicine, 2Biochemistry & Molecular Genetics, University of Wadsworth Center, Albany, NY Virginia, School of Medicine, Charlottesville, VA 2206 B558 Myosin Phosphatase Antagonizes Polo-Like-Kinase1 by 2216 B568 The Kinesin-13's, KLP59D & 2226 B578 BubR1 and APC/EB1 Cooperate Dephosphorylating the Activating Site of Thr210 KLP10A, Function Co-operatively during Mitosis to Maintain Metaphase Chromosome Alignment. of Polo-Like Kinase1 in Mammalian Cultured for Efficient Chromosome Segregation in J. Zhang, S. Ahmad, Y. Mao; Pathology and Cell Cells. F. Matsumura, Y. Yamakita, D. Lee, S. Drosophila S2 Cells. U. Rath,1 G. C. Rogers,2 D. Biology, Columbia University College of Physicians Yamashiro; Molecular Biology & Biochemistry, J. Sharp1; 1Physiology and Biophysics, Albert and Surgeons, New York, NY Rutgers, Piscataway, NJ Einstein College of Medicine, Bronx, NY, 2Department of Biology, University of North 2207 B559 Kinetochore-Microtubule Carolina, Chapel Hill, NC Kinetochores II Interactions Visualized by EM Tomography. J. 1 1 1 McIntosh, M. Morphew, D. Mastronarde, A. 2217 B569 Phosphorylation of Securin by 2227 B579 Molecular Architecture of 1 K. Zhudenkov,2 E. Grishchuk,1 F. Yefremov, Cdk1 Fine-Tunes Chromosome Segregation at Kinetochore-Microtubule Attachment Sites Is Ataullakhanov2; 1Department of Molecular/Cell/ the Metaphase to Anaphase Transition. L. J. Conserved between Point and Regional Developmental Biology, University of Colorado, Holt,1 D. O. Morgan,1 D. O. Morgan2; 1 2 3 2 Centromeres. A. Joglekar, X. He, J. Berman, E. Boulder, CO, National Research Center for 1Biochemistry, University of California, San Salmon,1 K. Bloom1; 1U. of N. Carolina, Chapel Hematology, Moscow, Russian Federation Francisco, San Francisco, CA, 2Physiology, Hill, NC, 2Molecular and Human Genetics, Baylor University of California, San Francisco, San 3 2208 B560 Kinetochore-associated College of Medicine, Houston, TX, Genetics, Cell Francisco, CA Regulators of Plus End Microtubule Dynamics Biology and Development, University of Minnesota, Minneapolis, MN Influence Spindle Pole Organization. A. L. 2218 B570 A Cruciform Intermediate in Manning, D. A. Compton; Dartmouth Medical rDNA Segregation in Budding Yeast. B. D. 2228 B580 The Kinetochore Localization of School, Hanover, NH Harrison; Biology, University of North Carolina, hZwint-1 Is Regulated by Phosphorylation. L. J. Chapel Hill, NC 2209 B561 Molecular Characterization of Vos, G. K. T. Chan; Oncology, University of 1 2 Alberta, Edmonton, AB, Canada Drosophila Kinetochore. M. Pereira, G. Costa, 2219 B571 Inner Centromere Aurora B M. Silva,1 C. Florindo,1 P. Roepstorff,3 A. Coelho,2 Kinase Activation Requires Priming 2229 B581 Localization of the Kinetochore Á. Tavares4; 1Instituto Gulbenkian de Ciência, Phosphorylation of Substrates as Well as TD-60 Microtubule End Relative to the Ndc80 Complex Oeiras, Portugal, 2Instituto de Tecnologia Química and Microtubules as Cofactors. S. E. Rosasco- in Mammalian Kinetochores. R. P. O'Quinn, X. e Biológica, Oeiras, Portugal, 3University Southern Nitcher, W. Lan, S. Khorasanizadeh, P. Wan, E. D. Salmon; Biology, University of North Denmark, Odense, Denmark, 4Departamento de Stukenberg; Biochemistry and Molecular Genetics, Carolina, Chapel Hill, NC Engenharia Química e Biológica, Instituto Superior University of Virginia, Charlottesville, VA Técnico, Universidade Técnica de Lisboa, Lisboa, 2230 B582 Kinetochore Assembly Is Portugal 2220 B572 The Ipl1/Aurora Protein Kinase Regulated by the Opposing Activities of Aurora and Glc7 Phosphatase Regulate the Cdc20 B Kinase and Protein Phosphatase 1. M. J. 2210 B562 Bod1, a Novel Kinetochore Activator of the Anaphase Promoting Complex. Emanuele, S. A. Miller, W. Lan, T. Stukenberg; Protein Is Required for the Efficient C. Kotwaliwale, B. Pinsky, S. Buvelot-Frei, S. 1 Biochemistry and Molecular Genetics, University of Phosphorylation of MCAK. I. M. Porter, S. Biggins; Division of Basic Science, Fred 2 2 1 Virginia, Charlottesville, VA McClelland, A. D. McAinsh, J. J. Blow, J. R. Hutchinson Cancer Research Center, Seattle, WA Swedlow1; 1Division of Gene Regulation and Expression, University of Dundee, Dundee, United Kingdom, 2Chromosome Segregation Laboratory, Marie Curie Research Institute, Oxted, Surrey, United Kingdom

164 The American Society for Cell Biology 47th Annual Meeting TUESDAY December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org Poster Session 3 B583–B614

2231 B583 Catalytic Production by 2241 B593 Phosphorylation-dependent 2253 B605 FIP3 Binding to the Unattached Kinetochores of the Mitotic Autoinhibition Regulates the Motility of the Centralspindlin Regulates Endosome Targeting Checkpoint “Wait Anaphase” Signal. A. Kinetochore Motor Cenp-E. J. Espeut,1 A. to the Midbody during Cytokinesis. G. C. Kulukian,1 J. S. Han,2 D. W. Cleveland2; 1Biology, Gaussen,1 P. Bieling,2 V. Morin,1 S. Prieto,1 D. Simon,1 E. Schonteich,1 T. Kutateladze,2 A. University of California, San Diego, La Jolla, CA, Fesquet,1 T. Surrey,2 A. Abrieu1; 1CRBM, CNRS, Piekny,3 M. Glotzer,3 R. Prekeris1; 1Department of 2Ludwig Institute for Cancer Research, University Montpellier, France, 2EMBL, Heidelberg, Germany Cell and Developmental Biology, University of of California, San Diego, La Jolla, CA Colorado Health Sciences Center, Aurora, CO, 2Department of Pharmacology, University of 2232 B584 Regulation of Hec1/hNdc80 Cytokinesis II Colorado Health Sciences Center, Aurora, CO, Function by Aurora B Phosphorylation. S. A. 3Department of Molecular Genetics and Cell Miller, P. Stukenberg; Biochemistry and Molecular 2242 B594 Characterization of Cytokinesis Biology, University of Chicago, Chicago, IL Genetics, University of Virginia, Charlottesville, VA Mutants in Saccharomyces cerevisiae. E. A. Vallen,1 J. H. Schreiter,2 H. Han,1 H. Bhattarai,1 E. 2254 B606 Dynamics of the Contractile 2233 B585 Phosphorylation of Hec1 by Bi2; 1Biology, Swarthmore College, Swarthmore, Ring Filament Network during Cytokinesis. A. NEK2A Promotes Kinetochore-Microtubule PA, 2Cell and Developmental BIology, University of Carvalho, A. Desai, K. Oegema; CMM-E, Ludwig Attachment Stability Essential for Mitotic Pennsylvania School of Medicine, Philadelphia, PA Institute for Cancer Research, La Jolla, CA Chromosome Congression. X. Cai,1 J. Du,2 S. Hua,2 J. Yao,2 Z. Wang,2 X. Wang,2 T. Ward,1 Y. 2243 B595 Characterization of the 2255 B607 Cytokinesis Contraction through Yang,1 C. Jin,2 X. Yao1; 1Cancer Biology Program, Septation Initiation Network (SIN) in Aspergillus the Remodeling of a Disordered Actin Network. Morehouse School of Medicine, Atlanta, GA, 2Hefei nidulans. T. Nayak, B. R. Oakley; Molecular E. M. Reichl,1 Y. Ren,1 M. K. Morphew,2 M. Laboratory of Cellular Dynamics, Hefei, China Genetics, Ohio State University, Columbus, OH Delannoy,3 J. C. Effler,1,4 K. D. Girard,1 S. Divi,1 P. A. Iglesias,4 S. C. Kuo,1,5,3 D. N. Robinson1,6; 2234 B586 Numerous Interactions Place 2244 B596 Functions of the PCH Family 1Department of Cell Biology, Johns Hopkins Cep57 at a Critical Interface in Kinetochore- Protein Hof1p in Saccharomyces cerevisiae University, Baltimore, MD, 2The Boulder Laboratory 1 Microtubule Attachment Sites. J. G. Tooley, M. during Cell Division. J. H. Schreiter, E. Bi; Cell for 3-D Electron Microscopy of Cells, The 1 2 2 J. Emanuele, K. Momotani, A. Somlyo, P. and Developmental Biology, University of University of Colorado, Boulder, CO, 3Institute for 1 1 Stukenberg ; Biochemistry and Molecular Pennsylvania, Philadelphia, PA Biomedical Sciences Microscope Facility, Johns Genetics, University of Virginia, Charlottesville, VA, Hopkins University, Baltimore, MD, 4Department of 2 Molecular Physiology and Biological Physics, 2245 B597 Cytokinesis in Dictyostelium Electrical and Computer Engineering, Johns discoideum Is Regulated by a SIN-Related University of Virginia, Charlottesville, VA Hopkins University, Baltimore, MD, 5Department of Pathway. P. M. Kastner, M. Schleicher, A. Müller- 2235 B587 The Regulation of Yeast Biomedical Engineering, Johns Hopkins University, Taubenberger; Cell Biology (ABI), Ludwig Baltimore, MD, 6Department of Pharmacology and Kinetochore Microtubule Dynamics by Maximilians University, Munich, Germany Kinetochore Proteins. K. Jaqaman,1 J. F. Dorn,1 Molecular Sciences, Johns Hopkins University, E. Marco,2 P. K. Sorger,2 G. Danuser1; 2246 B598 Chemical Genetic Analysis of Baltimore, MD 1 Department of Cell Biology, The Scripps Research the Role of Cdc2p in Regulating the Septation 2256 B608 Tektin 2 Is Required for 2 Institute, La Jolla, CA, Department of Systems Initiation Network (SIN) in S. pombe. S. Centrosome Duplication and Completion of 1 A. Krapp,1 L. Xie,2 J. Paulson,2 V. Biology, Harvard Medical School, Boston, MA Dischinger, Cytokinesis in Vertebrate Cells. T. M. Durcan, E. Simanis1; 1Cell Cycle Control Laboratory, ISREC, S. Halpin, E. K. Tribble, N. S. Collins, T. Rao, E. H. 2236 B588 Probing the Role of the PtK1 Epalinges, Switzerland, 2Department of Chemistry, Hinchcliffe; Biological Sciences, University of Notre Ndc80 Complex in Kinetochore-Microtubule University of Wisconsin–Oshkosh, Oshkosh, WI Attachment and the Spindle Assembly Dame, Notre Dame, IN Checkpoint. G. J. Guimaraes, J. G. DeLuca; 2247 B599 Regulation of an S. pombe Type Biochemistry, Colorado State University, Fort II Myosin by Phosphorylation. J. E. Friend,1 T. D. Cell Motility - Regulation III Collins, CO Pollard2; 1Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT, 2237 B589 A Complex of Septin7-CENP-E 2Molecular, Cellular and Developmental Biology; 2257 B610 Mechanism of MSP-based Cell Stabilizes the Kinetochore-Microtubule Body Retraction in the Amoeboid Sperm of Molecular Biophysics and Biochemistry, Yale 1 2 Attachment Essential for Chromosome Nematodes. K. Shimabukuro, M. Stewart, T. M. University, New Haven, CT 1 1 Segregation. M. Zhu,1 J. Du,1 F. Wang,1 J. Li,1,2 S. Roberts ; Florida State University, Tallahassee, 2 Keiko,3 K. Jiang,1 Y. Xuebiao1; 1Chemical Biology, 2248 B600 Torsion during Xenopus Embryo FL, MRC Laboratory of Molecular Biology, Chinese University of Science & Technology, Hefei, Cleavage: Rotationally Polarized Cortex or Cambridge, United Kingdom China, 2Cell Biology, Peking University, Beijing, Chirally Organized Contractile Ring? M. V. 2258 B611 Biochemical Basis of Cell Body China, 3Morehouse Medical School, Atlanta, GA Danilchik, E. E. Brown; Integrative Biosciences, Retraction in the MSP-based Motility of Ascaris Oregon Health & Science University, Portland, OR 1 2 1 2238 B590 Aurora B Regulation of hZW10 Sperm. K. Yi, M. Stewart, T. M. Roberts ; 1 Kinetochore Dynamics Is Required for Mitotic 2249 B601 Ultrastructure and Membrane Department of Biological Science, Florida State 2 Checkpoint Response to the Loss of Tension. J. Dynamics during Cytokinesis in the C. elegans University, Tallahassee, FL, MRC Laboratory of K. Famulski,1 G. K. T. Chan1,2; 1Oncology, Embryo. J. M. Squirrell, J. Campbell, J. G. White; Molecular Biology, Cambridge, United Kingdom University of Alberta, Edmonton, AB, Canada, Laboratory for Molecular Biology, University of 2259 B612 Kinetics of MSP Filament 2Experimental Oncology, Cross Cancer Institute, Wisconsin–Madison, Madison, WI Polymerization in Cell-free Extracts of the Edmonton, AB, Canada 2250 B602 Characterisation of ZW10 during Amoeboid Sperm of Ascaris. A. J. Malowney,1 M. 2 1 1 2239 B591 The Human Kinetochore Protein Cytokinesis in Drosophila Male Meiosis. A. Stewart, T. M. Roberts ; Biological Science, 2 Mcm21R/CENP-O Is Regulated in a Cell Cycle Wainman,1 M. Giansanti,2 M. Gatti2; 1Zoology, Florida State University, Tallahassee, FL, MRC Dependent Manner. M. Belwal,1 S. McClelland,2 A. University of Oxford, Oxford, United Kingdom, Laboratory of Molecular Biology, Cambridge, United McAinsh,2 P. Meraldi1; 1Institute of Biochemistry, 2Dipartmento di Genetica e Biologia Moleculare, Kingdom ETH Zürich, Zürich, Switzerland, 2Marie Curie Universita di Roma, Rome, Italy 2260 B613 Identification of Components of Research Institute, Oxted, United Kingdom 2251 B603 Distinct Signaling Mechanisms the MSP-based Motility System in C. elegans 2240 B592 CENP-E Is a Processive Drive Early and Late Steps in Furrow Formation Spermatozoa. E. L. Batchelder, L. Trichet, C. Kinetochore Motor. Y. Kim,1 J. E. Heuser,2 and Ingression. L. K. Lewellyn, A. Maddox, A. Sykes, J. Plastino; UMR 168 Physical Chemistry of C. M. Waterman,3 D. W. Cleveland1; 1Ludwig Desai, K. Oegema; Cellular and Molecular Living Organisms, Curie Institute, Paris, France Institute for Cancer Research, University of Medicine, Ludwig Institute for Cancer Research, La 2261 B614 Axonal Guidance Molecules Are California, San Diego, La Jolla, CA, 2Department of Jolla, CA Upstream Activators of the C. elegans WAVE/ Cell Biology, Washington University in St. Louis, St. 2252 B604 Midbodies Accumulate in Scar Actin Nucleation Complex. M. C. Soto, F. Louis, MO, 3Department of Cell Biology, The Patel, Y. Bernadskaya; Pathology, Robert Wood Scripps Research Institute, La Jolla, CA Putative Stem Cells. C. Chen; Molecular Medicine, University of Massachusetts Medical Johnson Medical School, Piscataway, NJ School, Worchester, MA

165 TUESDAY The American Society for Cell Biology 47th Annual Meeting Poster Session 3 B615–B644 December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org

2262 B615 W03H9.4 Is Required for 2273 B626 Receptor Protein Tyrosine 2282 B635 Spinal Muscular Atrophy: The Directional Control of Cell Migration and Cell Phosphatase ␮ Is a Negative Regulator of SMN - Actin Connection. J. van Bergeijk,1 C. Fate Decisions in Caenorhabditis elegans. V. Epidermal Growth Factor-mediated Signaling Grothe,1,2 P. Claus1,2; 1Neuroanatomy, Hannover Rodriguez, E. J. Cram; Biology, Northeastern and Migration in Human Lung Alveolar Medical School, Hannover, Germany, 2Center for University, Boston, MA Epithelial Cells. I. E. Anglin,1 S. W. Hyun,1 X. F. Systems Neuroscience (ZSN) Hannover, Hannover, Sui,1 T. D. Kiser,1 S. Yang,1 N. K. Tonks,2 A. Germany 2263 B616 Dynamic Actin-rich Structures Passaniti,1 S. E. Goldblum1; 1Medicine and Depend on Arp2/3 Function during C. elegans Pathology, Mucosal Biology Research Center, 2283 B636 Induction of Neurite Outgrowth ␤ 1 Gastrulation. M. Roh, B. Goldstein; University of University of Maryland, Baltimore, Baltimore, MD, in NB41A3 Cells by -bungarotoxin. P. Wu, L. 2 1 North Carolina–Chapel Hill, Chapel Hill, NC 2Cold Spring Harbor Laboratory, Cold Spring Chang ; Dept. of Kinesiology, Health and Leisure Harbor, NY Studies, National University of Kaohsiung, 2264 B617 Endoplasmic Reticulum at Cell Kaohsiung, Taiwan, 2Institute of Biomedical Leading Edge Is Essential to Regulate Cell 2274 B627 FAK Regulates Adhesion Sciences, National Sun Yat-Sen University, 1 2 1,3,2 Migration. X. Zhang, J. K. Heng, H. Yu ; Dynamics and Lamellipodial Persistence to Kaohsiung, Taiwan 1 Graduate Programme in Bioengineering, National Control Cell Motility: Defining the Signaling 2 University of Singapore, Singapore, Physiology, Pathways Involved in Macrophage Migration. K. 2284 B637 Mechanism of Inositol National University of Singapore, Singapore, A. Owen,1 K. S. Thomas,1 M. Vicente- Trisphosphate 3-kinase A-induced Alterations in 3 Institute of Bioengineering and Nanotechnology, Manzanares,2 B. J. Ray,1 J. T. Parsons,1 A. H. Dendritic Spine F-actin. H. Wu, M. J. Schell; Agency for Science, Technology and Research, Bouton1; 1Microbiology, University of Virginia, Pharmacology, Uniformed Services University, Singapore Charlottesville, VA, 2Cell Biology, University of Bethesda, MD 2265 B618 Chromatin Reorganization in Virginia, Charlottesville, VA 2285 B638 Septin Functions in C. elegans 1 Response to Migration Cues. G. Gerlitz, I. 2275 B628 The Channel-Kinase TRPM7 Is Axonal Dynamics. C. A. Morton, F. P. Finger; 2 3 3 2 1 Livnat, C. Ziv, O. Yarden, O. Reiner, M. Bustin ; Required for FAK Activation during Cell Biology Department and Center for Biotechnology 1 Laboratory of Metabolism, NCI, NIH, Bethesda, Spreading. L. Su, L. W. Runnels; Pharmacology, and Interdisciplinary Studies, Rensselaer 2 MD, Molecular Genetics, Weizmann Institute of University of Medicine & Dentistry of NJ–Robert Polytechnic Institute, Troy, NY 3 Science, Rehovot, Israel, Plant Pathology and Wood Johnson Medical School, Piscataway, NJ Microbiology, Hebrew University of Jerusalem, 2286 B639 Shootin1 Transmits Driving Rehovot, Israel 2276 B629 Fibroblasts in Wound Healing: Force of F-Actin-flow to L1-CAM for Neurite 1 1 Integrin Expression, Transformation, Motility, Elongation. T. Shimada, M. Toriyama, H. 2 3 4 2266 B619 High Glucose Concentration and Proliferation Differences in Syndecan-1- Kamiguchi, T. Sugiura, N. Watanabe, N. 1 1 Alters Cell Migration and Proliferation. M. L. deficient Mice. R. A. Jurjus, S. Pal-Ghosh, Y. Liu, Inagaki ; Division of Signal Transduction, Nara 1,2 2 1 1 Lamers, A. F. Horwitz, M. F. Santos ; Cell and G. Tadvalkar, M. Stepp; Anatomy and Cell Biology, Institute of Science and Technology, Ikoma, Nara, 2 Development Biology, University of Sao Paulo, Sao George Washington University, Washington, DC Japan, Neuronal Growth Mechanism, Brain Paulo, Brazil, 2Cell Biology, University of Virginia, Science Institute, RIKEN, Wako, Saitama, Japan, Charlottesville, VA 2277 B630 Intracellular Calcium Transients 3Biomedical Imaging and Informatics, Nara Institute Are Not Required for Keratocyte Motility. G. M. of Science and Technology, Ikoma, Nara, Japan, 2267 B620 Expression of Monocarboxylate Allen, J. A. Theriot; Department of Biochemistry, 4Department of Pharmacology, Kyoto University, Transporter 4 Is Required for Cell Migration In Stanford University, Stanford, CA Kyoto, Kyoto, Japan Vitro following Wounding of the Retinal Pigment Epithelium. S. M. Gallagher, N. J. Philp; 2278 B631 Analysis of Positive and 2287 B640 Myosin-II Activity Regulates Pathology, Anatomy and Cell Biology, Thomas Negative Photophobic Motile Responses in Minor Process Extension and the Development Jefferson University, Philadelphia, PA Diatoms. S. A. Cohn, Z. B. Kaplan, A. C. Pike, J. of Neuronal Polarity. K. M. Kollins, J. Hu, G. E. Sbarbaro; Biology, DePaul University, Chicago, Gallo; Neurobiology and Anatomy, Drexel 2268 B621 Troglitazone Suppresses IL University College of Medicine, Philadelphia, PA Transforming Growth Factor ␤-mediated Fibrogenesis in Retinal Pigment Epithelial Cells. 2279 B632 ARAP1 as a Novel Interacting 2288 B641 Intragenetic Compensation of Y. Tsao; Department of Ophthalmology, Mackay Protein of PTK6. S. Kang,1 E. Lee,1 H. Yoon,2 P. Tropomyosin Proteins in Neuronal Cells in an Memorial Hospital, Taipei, Taiwan Randazzo,2 S. Lee1; 1Department of Biochemistry, Exon-specific ␥-Tropomyosin Knockout Model. College of Science and Protein Network Research T. Fath,1,2 H. Clarke,1 A. Chan,1,2 G. Schevzov,1,2 2269 B622 Neuropilin-1 Uptake via Lipid Center, Yonsei University, Seoul, Republic of P. Gunning1,2; 1Oncology Research Unit, Children's Rafts Is Required for Semaphorin 3C Signaling. Korea, 2Laboratory of Cellular and Molecular Hospital at Westmead, Westmead, Australia, A. Horowitz, A. Salikhova; Angiogenesis Research Biology, Center for Cancer Research, National 2Discipline of Paediatrics and Child Health, Center, Dartmouth Medical School, Lebanon, NH Cancer Institute, Bethesda, MD University of Sydney, Sydney, Australia

2270 B623 Quinocarmycin Analog DX-52-1 2289 B642 Calpain Is a Novel Regulator of Inhibits Cell Migration and Targets Radixin, Nerve Cell Cytoskeleton Axon Consolidation. A. Mingorance-Le Meur,1,2 T. Disrupting Interactions of Radixin with Actin O'Connor1,2; 1Cellular and Physiological Sciences, 1 2 3 and CD44. A. W. Kahsai, S. Zhu, D. J. Wardrop, The University of British Columbia, Vancouver, BC, 4 1 1 2280 B633 Mitochondrial Biogenesis Can W. S. Lane, G. Fenteany ; Chemistry, University 2 Occur in the Axons of Vertebrate Peripheral Canada, ICORD, Vancouver, BC, Canada of Connecticut, Storrs, CT, 2Scripps Research Neurons. M. Amiri, P. J. Hollenbeck; Biological Institute, La Jolla, CA, 3Chemistry, University of 2290 B643 Phorbol 12-Myristate 13-Acetate Sciences, Purdue University, West Lafayette, IN Illinois, Chicago, IL, 4Harvard Microchemistry and (PMA) Regulates Neurite Outgrowth and Proteomics Analysis Facility, Harvard University, 2281 B634 Micropatterned Adhesive Microtubule Dynamics through PKC␦ in Cambridge, MA Substrates Reveal the Specific Response of Hippocampal Neurons. Y. Jung,1 J. Park,1 Y. Kim,2 K. Seo,1 K. Song,1 J. Kim,1 J. Park,1 E. + + Schwann Cell End Tip and DRG Neuron Growth 2271 B624 The Na /H Exchanger NHE1 1 1 1 1 Cone. F. Nothias,1 S. Féréol,1 R. Fodil,2 M. Yun, J. Kaipeng, H. Jun Young, G. Kweon, W. Modulates NGF-induced Neurite Outgrowth in 1 1 1 1 Barnat,1 M. Ravaille-Veron1; 1UMR7101, Yoon, K. Lim, B. Hwang ; Biochemistry, College PC12 Cells. D. M. Moniz, W. C. Sin, J. E. Tyler, J. Laboratoire de Neurobiologie des Signaux of Medicine, Chungnam National University, Church; Cellular and Physiological Sciences, 2 Intercellulaires, CNRS-UPMC, Paris, France, DaeJeon, Republic of Korea, Pharmacology, University of British Columbia, Vancouver, BC, 2INSERM UMR 841, Equipe Biomécanique College of Medicine, Chungnam National Canada Cellulaire et Respiratoire, INSERM UMR 841, University, DaeJeon, Republic of Korea Institut Mondor de Recherche Biomédicale, Créteil, 2272 B625 Epidermal Growth Factor 2291 B644 A Role for Reactive Oxygen France Stimulates Contractility and Focal Adhesion Species in Neuronal Growth Cone Motility. V. 1 Maturation and Turnover. I. Schneider, C. M. Munnamalai, D. M. Suter; Biological Sciences, 2 1 Waterman ; Cell Biology, The Scripps Research Purdue University, West Lafayette, IN Institute, La Jolla, CA, 2Cell Biology and Physiology Center, NIH/NHLBI, Bethesda, MD

166 The American Society for Cell Biology 47th Annual Meeting TUESDAY December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org Poster Session 3 B645–B676

2292 B645 Myosin II Is Required for 2302 B655 ␤Pix Inhibits the MAP1b LC1- 2312 B665 Modulation of the PKC1 Sensory Axon Extension on Laminin in the induced Microtubule Stabilization. D. Lee,1,2 M. Pathway by Ribosomal Gene Transcription in Absence of NGF. A. R. Ketschek, G. Gallo; G. Kim,1 D. Park2; 1Department of Biological Myosin II Deficient Yeast Strains. J. F. Neurobiology & Anatomy, Drexel University College Science, Inha University, Incheon, Republic of Rodríguez-Quiñones, J. R. Rodríguez-Medina; of Medicine, Philadelphia, PA Korea, 2Department of Biological Sciences, Seoul Biochemistry, University of Puerto Rico Medical National University, Seoul, Republic of Korea Sciences Campus, San Juan, Puerto Rico 2293 B646 Interaction of Close Homolog of L1 (CHL1) with ERM Proteins Promotes Neurite 2303 B656 Palmitoylation of Domain A of 2313 B666 Cdk5 Activity Regulates Myosin Elaboration and Sema3A-induced Growth Cone the Microtubule Regulating Stathmin Family Phosphorylation and Cell Migration in Lens Collapse. P. F. Maness,1 M. Schlatter,1 M. Buhusi,2 Proteins Controls Golgi vs Mitochondrial Epithelial Cells. B. K. Tripathi, P. S. Zelenka; A. Wright,1 S. Curran-Melendez1; 1Biochemistry, Subcellular Targeting. S. Chauvin, F. E. Poulain, Laboratory of Molecular and Devempmental University of North Carolina School of Medicine, A. Sobel; Institut du Fer à Moulin, INSERM/UPMC Biology, National Institutes of Health, Bethesda, Chapel Hill, NC, 2Neurosciences, Medical - UMRS 839, Paris, France MD University of South Carolina, Charleston, SC 2314 B667 Activating Mutations in Smooth 2294 B647 Spastin Is more Specialized Conventional Myosin Muscle Myosin in Colorectal Adenocarcinomas. than P60-katanin to Participate in the Formation D. Phichith; Physiology, University of Pennsylvania, of Axonal Branches. L. Qiang,1 W. Yu,1 J. 2304 B657 Characterization of an Philadelphia, PA Solowska,1 A. Karabay,2 S. Korulu,2 P. Baas1; Alternatively Spliced Isoform of Nonmuscle 1 2315 B668 Dynamin's Role in Apical Department of Neurobiology and Anatomy, Drexel Myosin II-C, NMHC II-C2. S. S. Jana,1 K. Kim,1 S. Constriction. J. Chua, R. Rikhy, J. Lippincott- University College of Medicine, Philadelphia, PA, Kawamoto,1 J. R. Sellers,1,2 R. S. Adelstein1; 2 Schwartz; NICHD, National Institutes of Health, Department of Molecular Biology and Genetics, 1Laboratory of Molecular Cardiology, National Bethesda, MD Istanbul Technical University, Istanbul, Turkey Institutes of Health, Bethesda, MD, 2Laboratory of Molecular Physiology, NHLBI, Bethesda, MD 2295 B648 Quantitative and Functional 2316 B669 Absence of the Drosophila UNC- 45 Chaperone Results in Depressed Myosin Analyses of Spastin in the Nervous System: 2305 B658 A Point Mutation in Nonmuscle Accumulation and Loss of Thick Filaments. C. Implications for Hereditary Spastic Paraplegia. Myosin II-C Is Associated with a Novel 1 2 1 F. Lee, G. C. Melkani, J. A. Suggs, A. Melkani, A. J. M. Solowska, G. Morfini, A. Falnikar, B. T. Lymphoproliferative Disease. K. Y. Kim,1 D. 1 2 2 1 Cammarato, S. I. Bernstein; Biology, San Diego Himes, S. T. Brady, D. Huang, P. W. Baas ; Shin,2 H. C. Morse,2 A. Snow,3 M. J. Lenardo,3 I. 1 State University, San Diego, CA Neurobiology and Anatomy, Drexel University Y. Hwang,4 C. Park,4 J. H. Kehrl,4 L. R. Brinster,5 College of Medicine, Philadelphia, PA, 2Anatomy 5 1 1 P. Zerfas, R. S. Adelstein ; Laboratory of 2317 B670 Specific Regulation of MIIA and and Cell Biology, University of Illinois at Chicago, Molecular Cardiology, NHLBI, National Institutes of MIIB through MLC Phosphorylation. M. Vicente- Chicago, IL 2 Health, Bethesda, MD, Laboratory of Manzanares, M. A. Koach, A. F. Horwitz; Cell Immunopathology, NIAID, National Institutes of 2296 B649 Kinesin-5 Is Required for Biology, University of Virginia, Charlottesville, VA Health, Bethesda, MD, 3Laboratory of Immunology, Growth Cone Turning. V. C. Nadar, A. Ketschek, NIAID, National Institutes of Health, Bethesda, MD, 2318 B671 Investigating the Role of JAK/ K. A. Myers, G. Gallo, P. W. Baas; Neurobiology 4Laboratory of Immunoregulation, NIAID, National STAT Signalling Pathway in Myosin II and Anatomy, Drexel University, Philadelphia, PA Institutes of Health, Bethesda, MD, 5Office of Recruitment during Cell Intercalation in the 2297 B650 Oriented Microtubule Growth at Research Services, National Institutes of Health, Drosophila Embryo. C. Bertet, T. Lecuit; IBDML, Dendrite Branch Points. F. J. Mattie, M. M. Rolls; Bethesda, MD Marseille, France Biochemistry and Molecular Biology, Pennsylvania 2306 B659 Diversity of Myosin II Isoforms 2319 B672 Rho-kinase Is Required for State University, University Park, PA in E-cadherin Regulation. M. Smutny, A. Yap; Epithelial Morphogenesis in the Drosophila 2298 B651 How Filopodial Actin Bundles Molecular Cell Biology, Institute for Molecular Embryo. R. Simone, S. DiNardo; Cell and Influence Microtubule Assembly Dynamics in Bioscience, Brisbane, Australia Molecular Biology, The University of Pennsylvania, Neuronal Growth Cones. D. T. Burnette,1 A. W. Philadelphia, PA 2307 B660 Using Homologous Schaefer,1 L. Ji,2 G. Danuser,2 P. Forscher1; Recombination to Replace Nonmuscle Myosin 2320 B673 Studies of Dictyostelium Myosin 1MCDB, Yale University, New Haven, CT, II-A with Human GFP-Myosin II-B in Mice. A. II Heavy Chain Kinase Autophosphorylation: 2Department of Cell Biology, The Scripps Research Wang,1 X. Ma,1 C. Liu,2 Y. Pinto,1 R. Adelstein1; Regulation during Development and Institute, La Jolla, CA 1LMC, NHLBI, Bethesda, MD, 2Transgenic Mouse Phosphorylation Site Mapping. T. T. Egelhoff,1 G. 2 3 4 1 2299 B652 Elk1 and Neurocytoskeletal Core Facility, NHLBI, Bethesda, MD P. Cote, Q. Medley, P. A. Steimle ; Physiology Interactions. Ö. Demir,1,2 A. Karabay,1 I. Aksan- and Biophysics, Case Western University School of 2308 B661 Myosin II-A-dependent 2 Kurnaz2; 1Molecular Biology and Genetics Medicine, Cleveland, OH, Biochemistry, Queens Activation of Rap1 in the Collagen Phagocytic University, Kingston, ON, Canada, 3Cancer Department, Istanbul Technical University, Istanbul, 1 2 2 Pathway. P. D. Arora, M. A. Conti, R. S. Immunology and AIDS, Dana Farber Cancer Turkey, Genetics and Bioengineering Department, 2 1 1 Adelstein, C. A. McCulloch ; CIHR in Matrix Institute, Boston, MA, 4Biology, University of North Yeditepe University, Istanbul, Turkey 2 Dynamics, Toronto, Canada, ON, Canada, NHLBI, Carolina at Greensboro, Greensboro, NC 2300 B653 Microtubule Orientation in Laboratory of Molecular Cardiology, NIH, Bethesda, Drosophila Neurons. M. C. Stone,1 F. Roegiers,2 MD 2321 B674 The Cellular Activities of M. M. Rolls1; 1Biochemistry and Molecular Biology, Dictyostelium Myosin Heavy Chain Kinases Are 2309 B662 Quantification of Nonmuscle The Pennsylvania State University, University Park, Specified by Homologous WD-Repeat Domains. 2 Myosin II Heavy Chain Isoforms Using Mass J. McKee, L. Hyatt, T. Russell, E. Fields, P. A. PA, Basic Science Division, Fox Chase Cancer 1 1 2 Spectroscopy. M. Conti, Y. Zhang, G. Wang, R. Steimle; Biology, University of North Carolina at Center, Philadelphia, PA 2 1 1 Shen, R. S. Adelstein ; Laboratory of Molecular Greensboro, Greensboro, NC 2301 B654 Tubulin Tyrosination Is Required Cardiology, National Institutes of Health, Bethesda, 2 for the Proper Organization and Pathfinding of MD, Proteomics Core Facility, National Institutes 2322 B675 Dictyostelium Myosin Heavy the Growth Cone. S. Marcos,1 S. Backer,1 A. of Health, Bethesda, MD Chain Kinase-A Competes Directly with Myosin Andrieux,2 D. Job,2 E. Bloch-Gallego1,3; 1Institut II for Binding to Actin Filaments. A. Chowdhury, 2310 B663 The Role of Nonmuscle Myosin Cochin - Dpt GDPM, INSERM U. 567, Paris, M. Keener, B. Petit, N. Havivi, P. A. Steimle; II in Mouse Heart Development. X. Ma, R. S. France, 2Laboratoire du Cytosquelette, DRDC, Biology, University of North Carolina at Adelstein; Laboratory of Molecular Cardiology, CEA-Grenoble, Inserm, U366, Grenoble, France, Greensboro, Greensboro, NC National Institutes of Health, Bethesda, MD 3Institut Cochin, Paris, France 2323 B676 The 10 S Hairpin Is Required for 2311 B664 The Phagocytic Synapse Nonmuscle Myosin-II Recycling at the Leading between Human Cells and Species-specific Edge of Mammalian Cells. M. T. Breckenridge, T. Inhibition by CD47 of Myosin-based T. Egelhoff; Department of Physiology and Engulfment. R. K. Tsai, D. E. Discher; University Biophysics, Case Western Reserve School of of Pennsylvania, Philadelphia, PA Medicine, Cleveland, OH

167 TUESDAY The American Society for Cell Biology 47th Annual Meeting Poster Session 3 B677–B704 December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org

2324 B677 Traction Force Microscopy in 2335 B688 The Ratio of ␤-tubulin Class II 2343 B696 Intermediate Filaments as Dictyostelium Reveals Distinct Roles for Myosin to V mRNA as a Clinically Useful Biomarker. V. Targets and Mediators of TNF-␣ induced II Motor and Actin Crosslinking Activity in Cucchiarelli,1 L. Hiser,2 J. J. Correia,1 S. Lobert2; Cleavage, Aggregate Formation and Cell Polarized Cell Movement. M. Lombardi,1 D. A. 1Department of Biochemistry, University of Junction Component Mislocalization. P. Knecht,1 M. Dembo,2 J. Lee1; 1Molecular and Cell Mississippi Medical Center, Jackson, MS, 2School Panagopoulou,1 D. L. Mann,2 Y. Capetanaki1; Biology, University of Connecticut, Storrs, CT, of Nursing, University of Mississippi Medical 1Center of Basic Research I, Cell Biology, 2Biomedical Engineering, Boston University, Center, Jackson, MS Biomedical Research Foudation, Academy of Boston, MA Athens, Athens, Greece, 2Winters Center for Heart ␤ 2336 B689 Class-V -tubulin Is Essential Failure Research, Baylor College of Medicine, 2325 B678 Signaling Pathways Regulating for Cell Proliferation. R. Bhattacharya, F. Cabral; Houston, TX Nonmuscle Myosin II-mediated Lamellipodial Integrative Biology and Pharmacology, University of Extension and Migration of Keratinocytes. V. Texas Medical School at Houston, Houston, TX 2344 B697 Intermediate Filaments Betapudi, J. Beach, L. Licate, T. Egelhoff; Exchange Subunits along Their Length and ␥ Physiology and Biophysics, Case Western Reserve 2337 B690 Differential Expression of - Elongate by End-to-End Annealing. G. University, Cleveland, OH tubulin Genes TUBG1 and TUBG2 in Non- Colakoglu, A. Brown; Center for Molecular neuronal Cells. S. Vinopal, V. Marková, E. Neurobiology, The Ohio State University, 2326 B679 VwkA, a Novel Protein Kinase Dráberová, V. Richterová, B. Šmejkalová, P. Columbus, OH Related to the Myosin II Heavy Chain Kinases Dráber; Laboratory of Biology of Cytoskeleton, IMG Family, Rescues Amoeba from Flooding. V. AS CR, Prague, Czech Republic 2345 B698 Deciphering the Assembly Betapudi, L. Licate, T. Egelhoff; Physiology and Mechanism of Vimentin Intermediate Filaments Biophysics, Case Western Reserve University, 2338 B691 Structural Aspects of the G- by Near-UV Circular Dichroism. S. ␣ Cleveland, OH protein Gs Contributing to a Functional Georgakopoulou,1 T. Wedig,2 N. Sachs,2 H. Interaction with Tubulin and Microtubules. R. Herrmann,2 U. Aebi1; 1Biozentrum, University of 1 2 2 2 2327 B680 Distinct Roles of the Myosin II Dave', W. Saengsawang, A. Sharma, J. Z. Yu, Basel, Basel, Switzerland, 2German Cancer 3 1 Isoforms in Mediating TNF-alpha-induced Cell M. M. Rasenick ; Department of Physiology and Research Center, Heidelberg, Germany Death. P. G. Flynn, D. Helfman; Cell Biology, MSTP Program, University of Illinois–Chicago University of Miami, Miami, FL College of Medicine, Chicago, IL, 2Department of 2346 B699 The Keratin "Treadmill". A. Physiology, University of Illinois–Chicago College of Kölsch, R. L. Leube, R. Windoffer; Anatomy and Medicine, Chicago, IL, 3Departments of Physiology, Cell Biology, Johannes Gutenberg–University Tubulin Psychiatry, and Neuroscience Program, University Mainz, Mainz, Germany of Illinois–Chicago College of Medicine, Chicago, IL 2328 B681 HDAC6 and SirT2 Are In Vivo 2347 B700 A Keratin 8 Head Domain Deacetylases of Unpolymerized Tubulin Glutamine Is Essential for Its Crosslinking by Protomer. T. P. Marmo, J. Bulinski; Biological Intermediate Filaments Transglutaminase-2 during Inclusion Body Sciences, Columbia University, New York, NY Formation. R. N. Kwan, P. Strnad, H. Shinichiro, 2339 B692 Tensile Properties of Single M. Omary; Gastroenterology, Stanford University, 2329 B682 Microtubule Deacetylation Is Desmin Filaments: Strain-hardening and Impact Palo Alto, CA Necessary for Fibroblast Polarization and of Disease Mutants. L. Kreplak,1 H. Bär,2 H. 2348 B701 Mutation of Keratin 8 Ser73 Bidirectional Vesicle Transport during Herrmann,2 U. Aebi1; 1M. E. Müller Institute, 1 Phosphorylation in Transgenic Mice Blocks Directional Migration. A. A. Salam, D. A. Biozentrum, Basel, Switzerland, 2Department of 1 1 2 1 Mallory-Denk Body Formation. M. Harada,1 S. Recinos, R. Kabaritti, T. Yao, J. Bulinski ; Molecular Genetics, German Cancer Research 1 Hanada,2 P. Strnad,2 N. O. Ku,2 R. Kwan,2 G. Z. Biological Sciences, Pathology & Cell Biology, Center, Heidelberg, Germany Columbia University, New York, NY, 2Pharmacology Tao,2 M. B. Omary2; 1Department of Medicine, and Cancer Biology, Duke University, Durham, NC 2340 B693 Linking Intermediate Filaments Division of Gastroenterology, Kurume University to the Muscle Cell by Interaction of School of Medicine, Japan, 2Department of 2330 B683 Tubulin Tyrosination Is a Major Human Synemin with Vinculin and Talin. N. Medicine, VA Palo Alto Health Care System and Factor Affecting the Recruitment of CAP-Gly Sun,1 Z. Li,2 D. Paulin,3 D. R. Critchley,4 R. M. Stanford University, Palo Alto, CA Proteins at Microtubule Plus-Ends. L. Peris, A. Robson1; 1Muscle Biology Group, Iowa State 2349 B702 Calcium-mediated Bridging of Andrieux, D. Job; Institut of Neuroscience-CEA University, Ames, IA, 2Pierre and Marie Curie Phosphorylated Neurofilaments (NFs) Promotes Grenoble, Grenoble, France University, Paris, France, 3Biologie Moleculaire de NF-NF association and Inhibits NF-Microtubule la Differenciation, Universite Paris, Paris, France, 2331 B684 Production of Antibodies Association: A Mechanism for Selective 4Department of Biochemistry, University of Specific for Glutamylated Proteins. A. Slowing of Axonal Transport of Phospho-NFs. Leicester, Leicester, United Kingdom Frankfurter, A. Spano; Biology, University of W. Chan,1 J. Kushkuley,1 J. Eyer,2 J. Leterrier,3 T. Virginia, Charlottesville, VA 2341 B694 GSK-3beta Regulates the Shea1; 1Biological Sciences, University of Transition of Neurofilament Subunits from Massachusetts–Lowell, Lowell, MA, 2University of 2332 B685 Site Directed Mutations of Punctate to Filamentous Structures. M. Dubey, Angers, Angers, France, 3University of Poitiers, Bacterial Tubulins BtubA/B That Block C. Moran, A. Alsaraby, W. Chan, T. B. Shea; Poitiers, France Assembly of Dimers and Protofilaments. C. A. Biological Sciences, Univeristy of Sontag,1 H. J. Sage,2 H. P. Erickson1; 1Department 2350 B703 Pin1 Dependent Prolyl Massachusetts–Lowell, Lowell, MA of Cell Biology, Duke University Medical Center, Isomerization Modulates the Stress Induced 2 Durham, NC, Department of Biochemistry, Duke 2342 B695 M30 and 4HNE Are Phosphorylation of NF-H: A Role in University Medical Center, Durham, NC Sequestrated in Different Aggresomes in ASH Neurodegenerative Disorders. P. Rudrabhatla, Y. 1 1 2 Zheng, N. Amin, P. Grant, W. Albers, S. 2333 B686 Effects of Reactive Oxygen and NASH. F. Amidi, B. French, D. Chung, H. 3 S. French1; 1Pathology, Harbor–UCLA Kesavapany, H. C. Pant; NINDS, National Institutes Species (ROS) on the ␤ Isotypes of Tubulin in Charles, Med Center, Torrance, CA, 2Internal Medicine, of Health, Bethesda, MD Differentiated Human SK-N-SH Neuroblastoma Harbor–UCLA Med Center, Torrance, CA, 3Internal Cells. J. Guo, R. F. Luduena; Biochemistry, 2351 B704 eIF3k Links Keratin 8/18 to Medicine, University of California, Davis School of University of Texas Health Science Center at San Regulate Caspase Distribution and Apoptosis in Medicine, Torrance, CA Antonio, San Antonio, TX Simple Epithelial Cells. Y. Lin,1 Y. Chen,2 J. Lin,2 I. Akihito,3 I. Masaki,3 Y. Wu,4 R. Chen5,1,2; 2334 B687 Interaction of Protozoan and 1Biochemical Sciences, Taipei, Taiwan, 2College of Plant Tubulins with Dinitroanilines and Medicine, NTU, Molecular Medicine, Taipei, Phosphorothioamidates Based on Common Taiwan, 3Division of Biochemistry, Aichi Cancer Structural Features. A. Y. Nyporko, A. I. Yemets, Center Research Institute, Nagoya, Japan, 4Life Y. B. Blume; Department of Genomics and Science, Molecular and Cellular Biology, Taipei, Biotechnology, Institute of Cell Biology and Genetic Taiwan, 5Academia Sinica, Biological Chemistry, Engineering, Kiev, Ukraine Taipei, Taiwan

168 The American Society for Cell Biology 47th Annual Meeting TUESDAY December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org Poster Session 3 B705–B732

2352 B705 Phosphorylation-dependent 2360 B713 Genetic Analyses Reveal 2369 B722 Determination of Kinetic Interaction of Keratins with Non-Muscle Myosin Tissue-specific Contributions of the Drosophila Parameters of Actin Polymerization Using II Heavy Chain Isoform C (NMHC II-C) in Colonic LEM Domain Proteins in the Nuclear Lamina. B. Surface Plasmon Resonance Technology. S. D. Epithelial Cells. G. Tao,1 D. M. Toivola,1 Q. Zhou,1 S. Pinto,1 S. R. Wilmington,2 E. E. L. Hornick,2 L. Kulkarni, J. F. Kusina, M. K. Schulte, T. B. Kuhn; Y. Tao,1 R. S. Adelstein,2 M. B. Omary1; 1Palo Alto L. Wallrath,2 P. K. Geyer2; 1Molecular and Cellular Chemistry & Biochemistry, University of Alaska, VAMC and Stanford University, Palo Alto, CA, 2The Biology Program, University of Iowa, Iowa City, IA, Fairbanks, Fairbanks, AK Laboratory of Molecular Cardiology, NHLBI, 2Department of Biochemistry, University of Iowa, National Institutes of Health, Bethesda, MD Iowa City, IA 2370 B723 Antiparalel Dimer Formation as a Distinctive Feature of Polycation-induced 2353 B706 Association of Novel Keratin 2361 B714 The Role of Intermediate Actin Polymerization. A. Muhlrad,1 E. Variants with Primary Biliary Cirrhosis. B. Filaments (IF) in the Changes in Cell Shape and Grintsevich,2 E. Reisler2; 1Institute of Dental Zhong,1,2 P. Strnad,1 G. Tao,1 C. Selmi,3 P. Motility That Accompany the Epithelial to Sciences, Hebrew University, Jerusalem, Israel, Invernizzi,3 M. Gershwin,4 A. Pietangelo,5 A. Mesenchymal Transition (EMT). M. G. Mendez, 2Department of Chemistry and Biochemistry, Caleffi,6 M. Omary1; 1Department of Medicine, VA Y. Chou, S. Kojima, R. D. Goldman; Cell and University of California Los Angeles, Los Angeles, Palo Alto Health Care System and Stanford Molecular Biology, Northwestern University, CA University, Palo Alto, CA, 2Division of Chicago, IL Gastroenterology, First Affiliated Hospital of Sun 2371 B724 Role of Intermonomer Ionic Yat-sen University, Guangzhou, China, 3Division of 2362 B715 Maintenance of the Intestinal Bridges in the Stabilization of the Actin Internal Medicine, University of Milan, Milan, Italy, Lumen in Caenorhabditis elegans: The Role of Filament. E. Stokasimov, M. McKane, P. A. 4Division of Rheumatology, Allergy, and Clinical the Intermediate Filament Protein IFC-2. K. Rubenstein; Biochemistry, University of Iowa, Iowa 1 2 1 Immunology, University of California Davis, Davis, Hüsken, T. Wiesenfahrt, C. Abraham, R. City, IA 1 2 1 CA, 5Center for Hemochromatosis, Department of Windoffer, O. Bossinger, R. E. Leube ; 1 2372 B725 WITHDRAWN Internal Medicine, University of Modena and Department of Anatomy, Johannes 2 Reggio Emilia, Modena, Italy, 6Department of Gutenberg–University, Mainz, Germany, Institute 2373 B726 Actin-based Propulsion along Internal Medicine, University of Modena and for Genetics, Heinrich-Heine-University, Düsseldorf, Curved Paths: Geometrical Description of the Reggio Emilia, Modena, Italy Germany Trajectories and a Microscopic Model for Torque Generation. V. Shenoy, D. Tambe; Brown 2354 B707 Keratins Are Susceptibility 2363 B716 Plectin-controlled Vimentin University, Providence, RI Genes for the Development of Acute Liver Cytoarchitecture Affects Signal Transduction Failure. P. Strnad,1 S. Hanada,1,2 Q. Zhou,1 B. Involved in Cellular Stress Response and 2374 B727 Constitutive Modeling of the Zhong,1,3 T. J. Davern,4 W. M. Lee,5 Acute Liver Migration. M. Gregor, G. Burgstaller, G. Walko, S. Stress-Strain Behavior of F-actin Filament Failure Study Group (ALFSG)5; 1Stanford Osmanagic-Myers, G. Wiche; Department of Networks. J. S. Palmer, M. C. Boyce; Mechanical University, Palo Alto, CA, 2Department of Medicine, Molecular Cell Biology, University of Vienna, Max F. Engineering, Massachusetts Institute of Kurume University School of Medicine, Kurume, Perutz Laboratories, Campus Vienna Biocenter, Technology, Cambridge, MA Japan, 3Division of Gastroenterology, The First Vienna, Austria Affiliated Hospital of Sun Yet-sen University, 2375 B728 Nucleotide-induced Modulation 2364 B717 ␤A3/A1-crystallin Is essential for Guangzhou, China, 4University of California San of the 165-172 Loop of Actin. D. S. Kudryashov,1 5 Intermediate Filament Assembly in Astrocytes. 1 2 1 Francisco, San Francisco, CA, University of Texas 1 2 1 1 E. E. Grintsevich, P. Rubenstein, E. Reisler ; D. Sinha, A. Nath, G. A. Lutty, J. S. Zigler, Jr. ; 1Chemistry and Biochemistry, University of Southwestern Medical Center, Dallas, TX 1Ophthalmology, Wilmer Eye Institute, The Johns California, Los Angeles, CA, 2Biochemistry, Roy A. 2355 B708 The Impact of Keratin 17 on Hopkins University School of Medicine, Baltimore, and Lucille A. Carver College of Medicine, 2Neurology, The Johns Hopkins University Tumor Dynamics in a Transgenic Mouse Model MD, University of Iowa, Iowa City, IA of Basal Cell Carcinoma. D. J. DePianto, P. A. School of Medicine, Baltimore, MD 2376 B729 Mechanical Redundancy of Coulombe; Biological Chemistry, Johns Hopkins 2365 B718 Genetic Background Plays an Cytoskeletal Networks. C. Semmrich,1 K. Kroy,2,3 University, Baltimore, MD Important Role in Mouse Hepatocyte Mallory- A. R. Bausch1; 1Lehrstuhl für Biophysik E22, Denk Body Formation. S. Hanada,1 P. Strnad,1 E. 2356 B709 PKC␣-dependent Modulation of Technische Universität München, Garching, M. Brunt,2 M. B. Omary1; 1Department of Medicine, Desmoplakin-Intermediate Filament Interactions Germany, 2Institut für Theoretische Physik, through Plakophilin 2 Promotes Desmoplakin VA Palo Alto Health Care System and Stanford 3 2 Universität Leipzig, Leipzig, Germany, Hahn- 1 Department of Assembly into Desmosomes. R. Hobbs, A. University, Palo Alto, CA, Meitner-Institut, Berlin, Germany Bass-Zubek,1 S. Hsieh,1 L. Godsel,1 E. Amargo,1 Pathology, St Louis University, St Louis, MO M. Denning,2 K. Green1; 1Pathology, Northwestern 2377 B730 The D. discoideum Actinome. J. 1 2 3 1 University, Chicago, IL, 2Pathology, Loyola Actin M. Joseph, P. Fey, X. I. Liu, N. Ramalingam, M. University, Maywood, IL Rohlfs,1 A. Müller-Taubenberger,1 G. Glöckner,4 M. Schleicher1; 1Cell Biology, Ludwig Maximilians 2357 B710 Mechanisms of Desmosome 2366 B719 Effects of Hydrolysis on Force University, Munich, Germany, 2Center for Genetic Disassembly in Response to Pemphigus Generation by Actin Filaments. A. E. Carlsson; Medicine, Northwestern University, Chicago, IL, Autoantibodies. J. M. Jennings, M. D. Kottke, A. Physics, Washington University, St. Louis, MO 3Department of Biology II, Ludwig Maximilians P. Kowalczyk; Department of Cell Biology and University, Munich, Germany, 4Fritz Lipmann 2367 B720 Properties of Actin from the Dermatology, Emory University, Atlanta, GA Institute, Leibniz Institute for Age Research, Jena, Fission Yeast Schizosaccharomyces pombe Germany 2358 B711 Analytical Ultracentrifugation and Interaction with Fission Yeast Profilin. M. 1 1,2 1 and Transmission Electron Microscopy of Takaine, I. Mabuchi ; Department of Biophysics 2378 B731 Regulation of Focal Adhesions Distinct Recombinant Human Lamin A and Biochemistry, Graduate School of Science, by Protein Arginylation. F. Zhang,1 S. Saha,1 T. 2 Complexes. H. Herrmann,1 D. Möller,1 N. Mücke,2 University of Tokyo, Tokyo, Japan, Department of Svitkina,2 A. Kashina1; 1Animal Biology, University L. Kapinos,3 U. Aebi3; 1Molecular Genetics, Life Sciences, Graduate School of Arts and of Pennsylvania, Philadelphia, PA, 2Biology, German Cancer Research Center, Heidelberg, Sciences, University of Tokyo, Tokyo, Japan University of Pennsylvania, Philadelphia, PA Germany, 2Biophysics of Macromolecules, German 2368 B721 Role of H-Bond between Human Cancer Research Center, Heidelberg, Germany, 2379 B732 Protrusion and Actomyosin 3M.E. Müller Institute for Structural Biology, Profilin1 D82 and Actin K113 in Actin Dynamics during Epithelial Sheet Wound University of Basel, Basel, Switzerland Regulation. K. Wen, A. Berger, M. McKane, P. Closure. J. I. Lim,1 M. Sabouri-Ghomi,1 C. M. Rubenstein; Biochemistry, University of Iowa, Iowa Waterman,2 G. Danuser1; 1Cell Biology, The 2359 B712 The Efficiency of Nuclear City, IA Scripps Research Institute, La Jolla, CA, Accumulation of Prelamin A Seems to Depend 2Laboratory of Cell and Tissue Morphodynamics, on an Intact Tail Domain. T. Kiel, A. Busch, S. National, Heart, Lung and Blood Institute/NIH, Huebner; University of Wuerzburg, Institute for Bethesda, MD Anatomy and Cell Biology, Wuerzburg, Germany

169 TUESDAY The American Society for Cell Biology 47th Annual Meeting Poster Session 3 B733–B734 December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org

2380 B733 Biochemical Characterization of the Bacterial Actin Homolog MreB from Bacillus subtilis. J. A. Mayer,1 G. J. Bean,1 K. J. Amann2; 1Molecular Biology, UW–Madison, Madison, WI, 2Zoology/Molecular Biology, UW–Madison, Madison, WI

2381 B734 Defective Growth Pattern and Nucleoid Organization Caused by Mutations in YhdE and rng of the Mre Locus in E. coli. Y. Shih; Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan

170 The American Society for Cell Biology

Wednesday December 5, 2007

47th Annual Meeting Washington, DC WEDNESDAY The American Society for Cell Biology 47th Annual Meeting December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

A/B 7:30 am –3:00 pm Registration Open (East Registration)

7:30 am –6:00 pm Late Posters on Display (Hall C)

8:00 am –9:30 am Symposium VII (Ballrooms A/B/C) Single Molecule Studies

9:00 am –3:00 pm Education Resources/MAC Booth (Grand Lobby)

9:45 am–10:15 am Education Initiative Forum (Room 140A) Yeast and Oxygen: Incorporating Functional Genomics Research into Three Integrated Undergraduate Laboratory Classes— Clare M. O’Connor, Boston College

10:30 am–12:00 Noon Symposium VIII (Ballrooms A/B/C) Cell Biology in Ten Years

12:00 Noon–3:00 pm Late Poster Presentations (Hall C) Odd Boards: 12:00 Noon–1:30 pm; Even Boards: 1:30 pm–3:00 pm

12:30 pm–1:30 pm Conversation with the NSF (Room 140B)

12:30 pm–2:30 pm Useful Databases for Cell Biologists Workshop (Room 143)

12:30 pm–2:30 pm Fluorescence Correlation Spectroscopy Workshop (Room 144 B/C)

3:15 pm–5:20 pm Minisymposium 25 (Ballroom A) Assembling Complex Cytoskeletal Structures Minisymposium 26 (Room 207) Cell Biology of the Synapse Minisymposium 27 (Room 202)

Daily Schedule—Wednesday, December 5 Daily Schedule—Wednesday, Chromatin Architecture and Remodeling Minisymposium 28 (Room 145) Extracellular Matrix as a Memory Storage Device Minisymposium 29 (Ballroom B) High-Tech Cell Biology Minisymposium 30 (Room 146) Regulatory Roles of Lipid Microdomains Minisymposium 31 (Room 147) RNA Silencing Mechanisms Minisymposium 32 (Ballroom C) Stem Cell Niches

172 The American Society for Cell Biology 47th Annual Meeting WEDNESDAY December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

ASCB Annual Meeting Highlights—Wednesday, December 5

Q Symposium VII 8:00 am –9:30 am Ballrooms A/B/C Single Molecule Studies Steve Kowalczykowski, University of California, Davis, Rob Phillips (Chair), California Institute of Technology, Paul Selvin, University of Illinois, Michelle Wang, Cornell University 8:00 am Introduction 8:10 am 2382 Single Molecule Measurements of Motor Proteins, In Vitro and In Vivo. P. R. Selvin; Department of Physics, University of Illinois, Urbana, IL 8:35 am 2383 Probing Nucleosome Stability and Structure at the Single Molecule Level. M. D. Wang; Department of Physics, Cornell University, Ithaca, NY 9:00 am 2384 Visualization of DNA Motor Proteins and Nucleoprotein Filaments at the Single-Molecule Level. S. C. Kowalczykowski; Microbiology and Molecular and Cellular Biology, University of California, Davis, Davis, CA

Q Education Initiative Forum 9:45 am–10:15 am Room 140A Refreshments Served

Sponsored by the Education Committee Yeast and Oxygen: Incorporating Functional Genomics Research into Three Integrated Undergraduate Laboratory Classes

Clare O’Connor Boston College

The availability of genomic information and clone resources for model organisms offers the opportunity for biology departments to provide original research experiences to large numbers of undergraduate students. Students enrolled in three advanced laboratory classes at Boston College design and conduct research projects centered around a common theme of oxidative stress defense in yeast, with the goal of publishing their results in peer-reviewed journals. Classes meet regularly for research conferences and use the Boston College Biology Commons (BC2) website as a central resource and discussion forum.

9:45 am 2385 Yeast and Oxygen: Building an Undergraduate Research Community Around a Common Research Theme. C. M. O’Connor; Biology, Boston College, Chestnut Hill, MA

173 WEDNESDAY The American Society for Cell Biology 47th Annual Meeting December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

Q Symposium VIII 10:30 am –12:00 Noon Ballrooms A/B/C Cell Biology in Ten Years Bruce Alberts (Chair), University of California, San Francisco, Benjamin F. Cravatt, III, The Scripps Research Institute, David Haussler, University of California, Santa Cruz, Stanislas Leibler, Rockefeller University 10:30 am Introduction 10:40 am 2386 Cell Biology in Ten Years: A Physicist’s Perspective. S. Leibler; Laboratory of Living Matter, The Rockefeller University, New York, NY 11:05 am 2387 Mapping Biochemical Pathways in Human Disease by Integrated Proteomics and Metabolomics. B. F. Cravatt; The Scripps Research Institute, La Jolla, CA 11:30 am 2388 Decoding Genomes with Comparative Genomics. D. Haussler; University of California, Santa Cruz, Santa Cruz, CA

Q Workshop 12:30 pm–2:30 pm Room 144 B/C Fluorescence Correlation Spectroscopy Workshop Daniel Needham, Harvard Medical School

Fluorescence correlation spectroscopy (FCS) is a powerful tool that can be used to measure the concentration, mobility, and interactions of molecules in cells quantitatively. This wireless interactive workshop is intended for cell biologists with little or no mathematical training who are interested in learning if FCS is a suitable technique to study their problems.

Q Workshop 12:30 pm–2:30 pm Room 143 Useful Databases for Cell Biologists David Haussler and Robert Kuhn, University of California, Santa Cruz, Center for Biomolecular Science & Engineering

Web-based genomics tools play an increasingly important role in cell biology. Attend this interactive wireless workshop (you must bring your own laptop) to learn about databases and analysis tools that help scientists understand the human and 38 other animal genomes.

Q Conversation with the NSF 12:30 pm–1:30 pm Room 140B Vision and Change: A Conversation on Preparing for the Future of Biology Undergraduate Education at the National Science Foundation You are invited to join one of an ongoing series of conversations to help shape NSF’s approaches to biology undergraduate education for the coming decades. Given the phenomenal rise of interest in cell biology, as well as the rapid pace of change in the science of biology and the potential for change in biology education, what should be our vision of and approach to biology undergraduate education for the decades to come? How can NSF funding best advance this vision? At this session you will learn about and have an opportunity to contribute to some upcoming NSF initiatives that we hope will address these challenges. Questions that will be addressed include:

Q What should be the main goals of the 21st century undergraduate life science curriculum, and how do these goals translate into desired outcomes? Q How do we design a curriculum to achieve these goals, and what is the best way to deliver that curriculum? Q How do we best prepare our faculty and structure our departments and institutions to achieve these goals?

174 The American Society for Cell Biology 47th Annual Meeting WEDNESDAY December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

Q Minisymposium 25 3:15 pm–5:20 pm Ballroom A Assembling Complex Cytoskeletal Structures Co-Chairs: Jacek Gaertig, University of Georgia, and Dave Kovar, The University of Chicago 3:15 pm Introduction 3:20 pm 2389 Assembly of the Fission Yeast Contractile Ring by Formin, Profi lin, and Tropomyosin. D. R. Kovar, E. M. Neidt, C. T. Skau, E. A. White; Molecular Genetics and Cell Biology, The University of Chicago, Chicago, IL 3:35 pm 2390 Actin Disassembly by Whole-Filament Destabilization. H. Kueh, T. J. Mitchison, W. M. Brieher; Department of Systems Biology, Harvard University, Boston, MA 3:50 pm 2391 Characterization of a Novel Vertebrate Actin Nucleation Factor. J. Zuchero, R. Mullins; Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 4:05 pm 2392 Adenomatous Polyposis Coli (APC) Protein Directly Nucleates Actin Assembly by a Novel Mechanism Involving Differential Regulation by mDia and EB1. K. Okada,1 A. M. Deaconescu,1 J. B. Moseley,1,2 N. Grigorieff,1,3 B. L. Goode1; 1Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, MA, 2The Rockefeller University, New York, NY, 3Howard Hughes Medical Institute, Waltham, MA 4:20 pm 2393 Branched Microtubules Drive Plant Cytokinesis. T. Murata,1,2 T. Sano, 3 S. Hasezawa,3 M. Hasebe1,2; 1National Institute for Basic Biology, Okazaki, Japan, 2Graduate School of Advanced Studies, Hayama, Japan, 3Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Japan 4:35 pm 2394 A Requirement of Xenopus Nudel, a Dynein Regulator, for Assembly of Spindle Precursors Enriched for Lamin B Matrix and γ-Tubulin. M. Li,1,2 R. Chen,1 O. Martin,1 X. Zhu,2 Y. Zheng1,2; 1Department of Embryology, The Carnegie Institution of Washington and Howard Hughes Medical Institute, Baltimore, MD, 2Cell Biology, Center for Cell Signaling, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China 4:50 pm 2395 Self Organization and Modularity in Centriole Assembly. A. P. Rodrigues-Martins; Cell Cycle Regulation Lab, Instituto Gulbenkian de Ciencia, Lisbon, Portugal 5:05 pm 2396 Tubulin Polymodifi cations Regulate the Assembly and Motility of Cilia in Tetrahymena. N. Sharma,1 S. Suryawanshi,1 D. Wloga,1 M. Jerka-Dziadosz,2 J. Gaertig1; 1Department of Cellular Biology, University of Georgia, Athens, GA, 2Department of Cell Biology, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland

Q Minisymposium 26 3:15 pm–5:20 pm Room 207 Cell Biology of the Synapse Co-Chairs: Edwin R. Chapman, University of Wisconsin–Madison, and Graeme W. Davis, University of California, San Francisco 3:15 pm Introduction 3:20 pm 2397 Synapse Stability Versus Degeneration: The Presynaptic Spectrin/Ankyrin Skeleton and Downstream Neuroprotective Signaling. C. M. Massaro, J. Pielage, L. Cheng, G. W. Davis; University of California, San Francisco, San Francisco, CA 3:35 pm 2398 Structural Integrity of the Mature Neuromuscular Junction Requires an Ankyrin-B-dependent Localization of β- Dystroglycan and /Utrophin. G. Ayalon, J. Q. Davis, V. Bennett; Cell Biology, Duke University Medical Center and HHMI, Durham, NC 3:50 pm 2399 How Does Thrombospondin Induce CNS Synaptogenesis? C. Eroglu,1 M. W. Susman,1 C. Chakraborty,1 A. D. Huberman,1 E. M. Green,1 D. Annis,2 D. Z. Luo,3 J. T. Lawler,4 R. Dolmetsch,1 D. Mosher,2 B. A. Barres1; 1Neurobiology, Stanford University, Stanford, CA, 2Department of Medicine, Medical Sciences Center, University of Wisconsin–Madison, WI, 3Departments of Anesthesiology and Pharmacology, University of California Irvine Medical Center, Orange, CA, 4Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 4:05 pm 2400 WASP Family Proteins Are Critical Regulators of Actin in the Development of Dendritic Spines and Synapses in Hippocampal Neurons. A. M. Wegner,1 C. A. Nebhan,2 D. Majumdar,2 K. M. Meier,2 A. M. Weaver,3 D. J. Webb2; 1Neuroscience Graduate Program, Vanderbilt University, Nashville, TN, 2Biological Sciences, Vanderbilt University, Nashville, TN, 3Cancer Biology, Vanderbilt University, Nashville, TN

175 WEDNESDAY The American Society for Cell Biology 47th Annual Meeting December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

4:20 pm 2401 Dance of the SNAREs: Assembly and Rearrangements Detected with FRET at Neuronal Synapses. R. S. Zucker; Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 4:35 pm 2402 Complexin Controls the Fate of SNARE Complex-lined Fusion Pores. S. J. An, C. Grabner, D. Zenisek; Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 4:50 pm 2403 Molecular Basis of Synaptic Vesicle Cargo Recognition by the Endocytic Sorting Adaptor Stonin 2. V. Haucke; Membrane Biochemistry, Freie Universitaet Berlin, Berlin, Germany 5:05 pm 2404 A Selective Activity-dependent Requirement for Dynamin 1 in Synaptic Vesicle Endocytosis. S. M. Ferguson,1 G. Brasnjo,2 M. Hayashi,1 M. Wolfel,1 C. Collesi,3 S. Giovedi,1 A. Raimondi,1 L. Gong,1 P. Ariel,4 S. Paradise,1 E. O’Toole,5 R. Flavell,6 O. Cremona,3 G. Miesenbock,1 T. A. Ryan,2 P. De Camilli7; 1Cell Biology, Yale University School of Medicine, New Haven, CT, 2Biochemistry, Weill Medical College of Cornell University, New York, NY, 3IFOM, Universita Vita- Salute San Raffaele, Milan, Italy, 4David Rockefeller Graduate Program, The Rockefeller University, New York, NY, 5Laboratory for 3D Electron Microscopy of Cells, University of Colorado at Boulder, Boulder, CO, 6Immunobiology, Yale University School of Medicine, New Haven, CT, 7Cell Biology, Yale University School of Medicine/HHMI, New Haven, CT

Q Minisymposium 27 3:15 pm–5:20 pm Room 202 Chromatin Architecture and Remodeling Co-Chairs: Laura Rusche, Duke University Medical Center, and Jerry Workman, Stowers Institute for Medical Research 3:15 pm Introduction 3:20 pm 2405 Building Silent Chromatin: Dynamics of SIR Spreading in Yeast. P. Lynch, L. Rusche; Department of Biochemistry, Duke University Medical Center, Durham, NC 3:35 pm 2406 A Molecular Mechanism for Aging-related Loss of Heterochromatin and DNA Damage. G. Pegoraro, T. Misteli; Cell Biology of Gene Expression, National Cancer Institute/NCI, Bethesda, MD 3:50 pm 2407 Remodeling of Interphase Chromatin Structure Caused by Ectopic Histone H3S10 Phosphorylation. H. Deng,1 X. Bao,1 W. Cai,1 M. J. Blacketer,1 A. S. Belmont,2 J. Girton,1 J. Johansen,1 K. M. Johansen1; 1Biochemistry, Biophysics, & Molecular Biology, Iowa State University, Ames, IA, 2Cell and Developmental Biology, University of Illinois at Urbana–Champaign, Urbana, IL 4:05 pm 2408 Fundamental Changes in Large-Scale Chromatin Organization Accompany Differentiation of Embryonic Stem Cells. P. B. Sinclair,1 Q. Bian,1 M. Plutz,1 E. Heard,2 A. S. Belmont1; 1Cell and Developmental Biology, University of Illinois, at Urbana-Champaign, Urbana, IL, 2Mammalian Development Epigenetics Group, Curie Institute, Paris, France 4:20 pm 2409 NSBP1: A Novel Protein Which Binds Specifi cally to Nucleosome in Euchromatin and Affects Cellular Differentiation. M. Rochman, M. Bustin; Laboratory of Metabolism, National Cancer Institute, Center for Cancer Resarch/NIH, Bethesda, MD 4:35 pm 2410 Global Interactions of the Glucocorticoid Receptor Require Extensive Chromatin Remodeling. S. John,1 T. A. Johnson,1 M. Sung,1 P. Sabo,2 S. R. Davis,3 P. S. Meltzer,3 J. Stamatoyannopoulos,2 G. L. Hager1; 1Laboratory of Receptor Biology and Gene Expression, National Cancer Institute/NIH, Bethesda, MD, 2Department of Genome Sciences, University of Washington, Seattle, WA, 3Clinical Molecular Profi ling Core, National Cancer Institute/NIH, Bethesda, MD 4:50 pm 2411 A Link between Transcription Elongation and Chromatin Reassembly via Nap1p and TREX. B. C. Del Rosario, L. F. Pemberton; Microbiology, University of Virginia, Charlottesville, VA 5:05 pm 2412 ATAC Is a Double Histone Acetyltransferase Complex That Stimulates Nucleosome Sliding. T. Suganuma, J. Gutierreze, B. Li, L. Florens, S. Swanson, M. P. Washburn, J. L. Workman; Stowers Institute for Medical Research, Kansas City, MO

Q Minisymposium 28 3:15 pm–5:20 pm Room 145 Extracellular Matrix as a Memory Storage Device Co-Chairs: Linda Gay Griffi th, Massachusetts Institute of Technology, and Patricia Keely, University of Wisconsin– Madison 3:15 pm Introduction 3:20 pm 2413 Self-assembling Peptide Hydrogels Functioning as a Synthetic ECM Differentially Mediate Chondrogenesis of Marrow- derived Mesenchymal Progenitor Cells. P. W. Kopesky, E. J. Vanderploeg, A. J. Grodzinsky; Center for Biomedical Engineering, Massachusetts Institute of Technology, Cambridge, MA 3:35 pm 2414 The Role of Cell Traction Force in Fibronectin Fibrillogenesis. C. A. Lemmon,1 H. P. Erickson,2 C. S. Chen,3 L. H. Romer4; 1Biomedical Engineering; Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, 176 The American Society for Cell Biology 47th Annual Meeting WEDNESDAY December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

MD, 2Cell Biology, Duke University Medical Center, Durham, NC, 3Bioengineering, University of Pennsylvania, Philadelphia, PA, 4Anesthesiology and Critical Care Medicine, Cell Biology, and Pediatrics, Johns Hopkins University, Baltimore, MD 3:50 pm 2415 Breast Epithelial Cells Adjust Their Contractile Response to 3D Matrix Density through Filamin A-β1 Integrin Interactions. S. Gehler,1 Y. Lad,2 M. Baldassarre,2 D. A. Calderwood,2 P. J. Keely1; 1University of Wisconsin–Madison, Madison, WI, 2Yale University School of Medicine, New Haven, CT 4:05 pm 2416 Syndecan-1 Expressing Mammary Fibroblasts Produce an Extracellular Matrix with Tumor Promoting Properties. N. Yang, A. Friedl; Department of Pathology and Laboratory Medicine, University of Wisconsin–Madison, Madison, WI 4:20 pm 2417 The Third Dimension Drives N-CoR2-dependent Death Resistance. K. K. Tsai,1 C. Chatterjee,2 J. N. Lakins,1 M. Nuth,2 M. E. Werner,1 I. S. Mian,3 J. Tobias,4 V. M. Weaver1; 1Surgery, University of California, San Francisco, San Francisco, CA, 2Pathology, University of Pennsylvania, Philadelphia, PA, 3Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, 4Bioinformatics Core, University of Pennsylvania, Philadelphia, PA 4:35 pm 2418 A Novel Link Between Exposure of Prolactin Receptor, Sustained Activation of STAT5, and Histone Acetylation in Regulation of Differentiated Function in Mammary Epithelial Cells in Three Dimensional Cultures. R. Xu, C. M. Nelson, M. Veiseh, M. J. Bissell; Life Science Division, Lawrence Berkeley National Laboratory, Berkeley, CA 4:50 pm 2419 Cell Adhesion Regulates Ras, but Not Rho-dependent SRF-mediated Gene Transcription. M. A. Wozniak,1 C. Q. Cheng,1 D. M. Pirone,2 C. S. Chen1; 1Bioengineering, University of Pennsylvania, Philadelphia, PA, 2Science Department, Mt. St. Mary’s University, Emmitsburg, MD 5:05 pm 2420 Identifying Matrix- and Growth Factor-induced Transcriptional Dichotomies by Stochastic Sampling. K. A. Janes, J. S. Brugge; Cell Biology, Harvard Medical School, Boston, MA

Q Minisymposium 29 3:15 pm–5:20 pm Ballroom B High-Tech Cell Biology Co-Chairs: Grant Jensen, California Institute of Technology, and Kendall Knight, University of Massachusetts Medical School 3:15 pm Introduction 3:20 pm 2421 3-D Ultrastructure of Ostreococcus tauri: Electron Cryotomography of an Entire Eukaryotic Cell. L. Gan, G. P. Henderson, G. J. Jensen; Biology, California Institute of Technology, Pasadena, CA 3:35 pm 2422 Multi-Resolution Spatio-temporal Analysis of Mammalian Cells Reconstructed in Toto in 3D by Electron Tomography (ET). B. J. Marsh,1,2,3 A. J. Costin,1 M. Floetenmeyer,1 J. Galea,1 J. Goh,1 D. N. Mastronarde,4 G. P. Morgan,1 A. B. Noske,1,2 P. A. van der Heide,1 N. Volkmann5; 1Molecular Cell Biology, Institute for Molecular Bioscience, University of Queensland, St Lucia, Australia, 2ARC Centre of Excellence in Bioinformatics, University of Queensland, Brisbane, Australia, 3Centre for Microscopy & Microanalysis and School of Molecular & Microbial Sciences, University of Queensland, St Lucia, Australia, 4Molecular, Cellular, & Developmental Biology, Boulder Laboratory for 3-D Electron Microscopy of Cells, University of Colorado at Boulder, Boulder, CO, 5Bioinformatics & Systems Biology, Burnham Institute for Medical Research, La Jolla, CA 3:50 pm 2423 Mitochondrial Morphology: Quantifying Topological Network Properties in 3 Dimensions. S. Rafelski,1 M. P. Viana,2 P. M. Carlton,1 J. W. Sedat,1 L. da F. Costa,2 W. F. Marshall1; 1Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, 2Inst. de Fisica de Sao Carlos, USP, Sao Carlos, Sao Paulo, Brazil 4:05 pm 2424 From Sorting Endosomes to Plasma Membrane and Back: 3D Single Molecule Imaging of Exo/Endocytic Pathways Using Multifocal Plane Microscopy. S. Ram,1 P. Prabhat,2,1 J. Chao,3,1 Z. Gan,1 E. Ward,1 R. Ober3,1; 1Immunology, University of Texas Southwestern Medical Center, Dallas, TX, 2Electrical Engineering, University of Texas at Dallas, Richardson, TX, 3Electrical Engineering, University of Texas at Dallas, Dallas, TX 4:20 pm 2425 DNA Damage Signaling Events Revealed by 4Pi Microscopy. J. Bewersdorf,1 M. D. Lessard,1 B. T. Bennett,2,3 K. L. Knight2; 1Institute for Molecular Biophysics, The Jackson Laboratory, Bar Harbor, ME, 2Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA, 3Lake Placid Biologicals, Lake Placid, NY 4:35 pm 2426 Novel Microscopy Methodology to Examine DNA Damage Signaling and Repair. B. T. Bennett; Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 4:50 pm 2427 Dynamics of Viral RNA Replication in Living Cells. T. Saleh,1 S. Marras,2 S. Tyagi,2 N. Altan-Bonnet1; 1Rutgers University, Newark, NJ, 2University of Medicine & Dentistry of New Jersey, Newark, NJ 5:05 pm 2428 Label-Free, Single-Molecule Detection of Cytokines in Serum Using Optical Microcavities. A. M. Armani,1 S. E. Fraser,2 K. J. Vahala1; 1Applied Physics, California Institute of Technology, Pasadena, CA, 2Biology, California Institute of Technology, Pasadena, CA

177 WEDNESDAY The American Society for Cell Biology 47th Annual Meeting December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

Q Minisymposium 30 3:15 pm–5:20 pm Room 146 Regulatory Roles of Lipid Microdomains Co-Chairs: Barbara A. Baird, Cornell University, and Michael Edidin, Johns Hopkins School of Medicine 3:15 pm Introduction 3:20 pm 2429 Lipid Domains Are Only Part of the Story. M. Edidin, S. R. Shaikh; Department of Biology, Johns Hopkins University, Baltimore, MD 3:35 pm 2430 Critical Fluctuations in Plasma Membrane Vesicles. S. Veatch, P. Sengupta, D. Holowka, B. A. Baird; Chemistry and Chemical Biology, Cornell University, Ithaca, NY 3:50 pm 2431 Store-operated Ca2+ Entry Signaling at Endoplasmic Reticulum and Plasma Membrane Junctions. J. Liou, T. Meyer; Stanford University, Stanford, CA 4:05 pm 2432 Cholesterol-dependent Dynamics of Nicotinic Acetylcholine Receptor at the Cell Membrane. F. J. Barrantes; UNESCO Chair, Biophysics & Molecular Neurobiology/Institute of Biochemistry, Bahia Blanca, Argentina 4:20 pm 2433 The Role of GM1 in Mammalian Sperm Signaling Pathways. D. Buttke,1 V. Selvaraj,1 A. Asano,1 J. Nelson,2 A. Travis2; 1Cornell College of Veterinary Medicine, Ithaca, NY, 2The Baker Institute for Animal Health, Cornell College of Veterinary Medicine, Ithaca, NY 4:35 pm 2434 Cholesterol Loading Disrupts the Subcellular Distribution of Prenyl-Polybasic Domain Proteins. W. B. Alford,1 J. Rhayem,1 L. A. Lapierre,2 J. R. Goldenring,2,3 E. L. Snapp,4 A. K. Kenworthy1,3; 1Molecular Physiology and Biophysics, Vanderbilt School of Medicine, Nashville, TN, 2Surgery, Vanderbilt School of Medicine, Nashville, TN, 3Cell and Developmental Biology, Vanderbilt School of Medicine, Nashville, TN, 4Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 4:50 pm 2435 Lipid Raft/Caveolae Localization and Traffi cking Regulates Gs Alpha/Adenylyl Cyclase Signaling. J. A. Allen,1 J. Zhou- Yu, 1 R. J. Donati,2 B. L. Roth,3 M. M. Rasenick1; 1Department of Physiology and Biophysics, University of Illinois at Chicago–College of Medicine, Chicago, IL, 2Department of Basic and Health Sciences, Illinois College of Optometry, Chicago, IL, 3Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, NC 5:05 pm 2436 Imaging Membrane Dynamics in Immunoreceptor Signaling. E. D. Sheets; Chemistry, Pennsylvania State University, University Park, PA

Q Minisymposium 31 3:15 pm–5:20 pm Room 147 Supported by Merck Research Laboratories RNA Silencing Mechanisms Co-Chairs: Natasha J. Caplen, National Cancer Institute/NIH, and Alla Grishok, Columbia University 3:15 pm Introduction 3:20 pm 2437 Transcription Profi ling in C. elegans Reveals Functional Gene Expression Programs Regulated by the RNAi Pathway and Retinoblastoma Genes. A. Grishok,1,2 S. Hoersch,1 P. A. Sharp1; 1Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 2Department of Biochemistry & Molecular Biophysics, Columbia University, New York, NY 3:35 pm 2438 Heterochromatin Formation in Fission Yeast. F. Li , 1 M. Huarte,2 Y. Shi,2 R. Martienssen,3 W. Z. Cande1; 1Department of Molecular & Cell Biology, University of California, Berkeley, Berkeley, CA, 2Department of Pathology, Harvard Medical School, Boston, MA, 3Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 3:50 pm 2439 Global Expression Dynamics of MicroRNAs and Predicted MicroRNA Targets in Developing, Naïve, and Activated T Lymphocytes. J. R. Neilson,1 R. T. H. Sandberg,2 G. X. Y. Zheng,1,3 C. B. Burge,3,2 P. A. Sharp1,2; 1Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 2Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 3Computational and Systems Biology Graduate Program, Massachusetts Institute of Technology, Cambridge, MA 4:05 pm 2440 Piwi Proteins and Associated Small RNAs in Germline Development. A. Aravin, J. Brenneck, R. Sachidanandam, A. Girard, G. J. Hannon; Cold Spring Harbor Laboratory, Howard Hughes Medical Institute, Cold Spring Harbor, NY 4:20 pm 2441 Applications of RNAi Screens in the Study of Cancer-associated Processes. S. E. Martin,1 T. L. Jones,1 P. Lorenzi,2 E. Lader,3 J. Weinstein,2 Y. Pommier,2 K. Huppi,1 N. J. Caplen1; 1Gene Silencing Section, Genetics Branch, Center for Cancer Research, National Cancer Institute/NIH, Bethesda, MD, 2Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute/NIH, Bethesda, MD, 3Qiagen, Inc., Germantown, MD 4:35 pm 2442 Genetic Analysis of Endothelial Wound Closure Reveals Distinct Signaling Modules Controlling Wound Dependent and Independent Cell Migration. P. Vitorino, T. Meyer; Stanford University, Stanford, CA

178 The American Society for Cell Biology 47th Annual Meeting WEDNESDAY December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

4:50 pm 2443 RNAi Suppression of Motor Proteins in Drosophila Primary Neurons: Dissection of the Axonal Transport of Mitochondria. D. Pathak, P. J. Hollenbeck; Biological Sciences, Purdue University, West Lafayette, IN 5:05 pm 2444 Anti-fi brotic Property of CTGF siRNA in the Liver via Targeted Delivery to Hepatic Stellate Cells. C. Lawrencia, D. R. Brigstock; Cell & Vascular Biology, Children’s Research Institute, Columbus, OH

Q Minisymposium 32 3:15 pm–5:20 pm Ballroom C Stem Cell Niches Chair: Leanne Jones, Salk Institute for Biological Studies, and Haifan Lin, Yale University 3:15 pm Introduction 3:20 pm 2452 Artifi cial Niches for High-throughput Dynamic Analyses of Single Adult Stem Cells. H. Blau,1 R. Doyonnas,1 M. Lütolf2; 1Baxter Laboratory in Genetic Pharmacology, Stanford University, Stanford, CA, 2School of Life Sciences, Swiss Federal Institute of Technology, Lausanne, Switzerland 3:35 pm 2446 Interactions between Stem Cells and Their Niche in the Drosophila Ovary. T. Xie; Stowers Institute for Medical Research, Kansas City, MO 3:50 pm 2447 Dissecting Self-Renewal in Stem Cells with RNA Interference. N. B. Ivanova, R. Dobrin, R. Lu, I. Kotenko, J. Levorse, C. DeCoste, X. Schafer, I. R. Lemischka; Molecular Biology, Princeton University, Princeton, NJ 4:05 pm 2448 Intercellular Transfer as a Mechanism of Cell Communication within the Hematopoietic Progenitor Niche. J. M. Gillette, J. Lippincott-Schwartz; Cell Biology & Metabolism Branch, National Institute of Child Health & Human Development/NIH, Bethesda, MD 4:20 pm 2449 Counting Divisions in the Hair Follicle Stem Cells Pool. T. Tumbar, S. Waghmare, K. Osorio, D. McDermitt, Y. Zhang, S. Lee, J. Lee; Molecular Biology and Genetics, Cornell University, Ithaca, NY 4:35 pm 2450 Mechanisms of Stem Cell Homeostasis. W. Zhong; Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 4:50 pm 2451 Stem Cells, Small RNAs, and Self-Renewal. H. Lin,1 H. Yin,1 E. Beyret,1 S. Grivna2; 1Yale Stem Cell Center, Yale University School of Medicine, New Haven, CT, 2Department of Cell Biology, Duke University School of Medicine, Durham, NC 5:05 pm 2445 Somatic Stem Cells Maintain the Niche in the Drosophila Testis. J. Voog, L. Jones; Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, CA

179 WEDNESDAY The American Society for Cell Biology 47th Annual Meeting December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

Late Poster Session Hall C

Poster Set Up Tuesday 7:00 pm–7:30 pm

Posters Displayed Tuesday 7:00 pm–9:00 pm Wednesday 7:30 am–6:00 pm

Author Presentation Odd Boards 12 Noon–1:30 pm Even Boards 1:30 pm–3:00 pm

Poster Tear Down Wednesday 3:00 pm–6:00 pm

Annual Meeting Poster Presentation Guidelines • Presenters should ensure their posters are placed on the appropriate poster board for the duration of their as- signed poster sessions (the full 24-hour period). In cases of emergency, poster presenters who are unable to present should contact the ASCB at [email protected] to withdraw their abstract(s) before the Annual Meeting. In the case of withdrawn posters, a “WITHDRAWN” sign will be posted, along with the author’s contact information, on the poster board. • Poster presenters should stand at their poster locations during the appropriate 90-minute time slot—12:00 Noon–1:30 pm, or 1:30 pm–3:00 pm. (The specifi c information is included in the original poster notifi cation emails sent in September.) If presenters have to leave early, they should post a note on their boards stating when they will be available to answer attendee questions. • Cameras/Photography: Cameras and all other recording devices are strictly prohibited in all session rooms, on the Exhibit fl oor, and in all poster and oral presentation sessions.

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Visit us at booth #1326 www.mbfbioscience.com The American Society for Cell Biology 47th Annual Meeting EXHIBITORS December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

The American Society for Cell Biology

47th Annual Meeting Washington D.C. Convention Center Washington, D.C. December 1–5, 2007

Exhibit Hours

Sunday, December 2 9:00 am–4:00 pm Monday, December 3 9:00 am–4:00 pm Tuesday, December 4 9:00 am–4:00 pm

The American Society for Cell Biology gratefully acknowledges the support of exhibiting companies and Annual Meeting supporters

181 EXHIBITORS The American Society for Cell Biology 47th Annual Meeting December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org

THE AMER

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182 The American Society for Cell Biology 47th Annual Meeting EXHIBITORS December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org

THE 47TH ANNUAL MEETING OF THE ERICAN SOCIETY FOR CELL BIOLOGY DECEMBER 2-5, 2007 WASHINGTON CONVENTION CENTER WASHINGTON , DC

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183 EXHIBITORS The American Society for Cell Biology 47th Annual Meeting December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org ANNUAL MEETING EXHIBITORS AND BOOTH NUMBERS

µMANAGER 1252 A SLICE OF LIFE 242 ACADEMIA BOOK EXHIBITS 223 Genentech Hall, UCSF 818 Tolman Drive 3512 Willow Green Court Room N316 600 16th Street Stanford, CA 94305 Oakton, VA 22124 San Francisco, CA 94143 Tel: 650-493-1019 Fax: 650-856-7699 Tel: 703-716-5537 Fax: 703-620-3676 Tel: 415-514-3927 Fax: 415-476-5233 asliceoflifescarves.com acadbkex.com www.micro-manager.org A Slice Of Life offers elegant silk scarves and ties Academia exhibits professional books and journals in Micro-Manager is an Open Source application for with patterns derived from cell structures seen at high a multi-publisher display. A free catalog is available microscope control and image acquisition. The soft- magnification. The patterns capture the essence of on request. ware runs on multiple platforms (Windows, Mac, structures related to cell movement, cell traffic, energy Linux), supports many hardware components, and production, hormone production, lipoproteins, cell ACCURATE CHEMICAL & can be altered by end-users. We are based in Ron division, neural activity, protein expression, and SCIENTIFIC CORPORATION 905 Vale’s Laboratory at UCSF and funded by grants from others. 300 Shames Drive the Sandler Foundation. 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In its on-line cata- is so intuitive that you can be up and running within 20/20 Technology manufactures and markets temper- log, Abcam lists more than 35,000 primary and sec- an hour of receiving your Accuri system. ature controlled systems and miniature, precision ondary antibodies in all major research areas. incubators for microscopes and biological applica- ACS PUBLICATIONS 238 tions. We will be featuring our Bionomic System, Bios- ABD SEROTEC 806 1155 16th Stret, NW tages, Inc-2000 Incubator System and Objective 3200 Atlantic Avenue Suite 125 Washington, DC 20036 Heaters. 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Visit Booth 238 to register on the www.21stcenturybio.com custom monoclonal antibodies can be generated in ACS Chemical Biology website and pick up a sample Custom peptides with free peptide sequence confir- just 8 weeks — a unique service backed by a No issue of the journal. mation available only from 21st Century Biochemicals! Antibody? No Charge! Guarantee. Custom phosphospecific antibodies as low as $2395 ACTIVE MOTIF, INC. 555 from epitope design to purified antibody; custom anti- ABGENT, INC. 711 1914 Palomar Oaks Way, Suite 150 bodies starting from $685. PhosphoExplorationTM 6310 Nancy Ridge Drive, Suite 106 Carlsbad, CA 92008 localizes phosphorylation sites on your protein with San Diego, CA 92121 Tel: 760-431-1263 Fax: 760-431-1351 phosphospecific antibody/phosphopeptide produc- Tel: 858-622-0099 Fax: 858-622-0609 www.activemotif.com tion. Complete Mass Spectrometry Services-Protein www.abgent.com Active Motif is a biotechnology company developing ID/PTM analysis/ 2D gels. 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ADOBE SYSTEMS, INC. 1247 erated generation of novel, functional monoclonal anti- 345 Park Avenue bodies for biotechnology and pharmaceutical compa- ABR--AFFINITY BIOREAGENTS 1154 San Jose, CA 9511O nies as well as federal and academic laboratories. 4620 Technology Drive, Suite 600 Tel: 408-536-6000 Fax: 408-537-6000 A&G is able to develop mAbs within 40 days with a Golden, CO 80403 www.adobe.com success rate exceeding 90%. We have developed Tel: 303-278-4535 Fax: 303-278-2424 Adobe® Photoshop® CS3 Extended software --offer- over 350 biologically functional antibodies and have www.bioreagents.com ing powerful digital imaging tools to help you capture, become the preferred vendor for over 14 organiza- ABR--Affinity BioReagents provides over 30,000 qual- interpret, and disseminate visually rich information. tions. ity guaranteed monoclonal and polyclonal antibodies for 42 areas of basic research. 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184 The American Society for Cell Biology 47th Annual Meeting EXHIBITORS December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org

ADVANCED TARGETING SYSTEMS 602 AMAXA AG 638 AMERICAN RADIOLABELED 11175-A Flintkote Avenue Nattermannallee 1 CHEMICALS, INC. 1349 San Diego, CA 92121 Koeln, NRW, 50829 Germany 101 ARC Drive Tel: 858-642-1988 Fax: 858-642-1989 Tel: 011-49-221-99199-400 Fax: 011-49-221- St. Louis, MO 63146 www.atsbio.com 99199-499 Tel: 314-991-4545 Fax: 314-991-4692 Advanced Targeting Systems, “the saporin people,” www.amaxa.com arc-inc.com provides quality targeting reagents for molecular sur- amaxa develops and commercializes innovative prod- American Radiolabeled Chemicals, Inc has more than gery: the specific elimination of cells to examine the ucts for the transfer of DNA or siRNA into cells. Its 3000 radiolabeled as well as unlabeled chemicals impact on behavior and/or disease states. The product unique Nucleofector® technology provides a break- including many unusual and exclusive products. line includes targeted toxins and antibodies. ATS also through tool for the highly efficient, non-viral transfec- has second conjugates that let researchers create tion of primary cells and hard-to-transfect cell lines. AMERICAN SOCIETY FOR their own specific targeting tools and are particularly Now also in 96-well format. BIOCHEMISTRY AND MOLECULAR useful in antibody screening for internalization. BIOLOGY 244 AMERICAN BIOTECHNOLOGY 9650 Rockville Pike ADVANGENE CONSUMABLES, INC. 713 LABORATORY 528 Bethesda, MD 20814 21 North Skokie Highway, Suite 104 30 Controls Drive Tel: 301-634-7377 Fax: 301-634-7108 Lake Bluff, IL 60044 Shelton, CT 06484 www.asbmb.org Tel: 847-283-9780 Fax: 847-295-7411 Tel: 203-926-9300 Fax: 203-926-9310 Founded in 1906, the Society is based in Bethesda, www.advangene.com www.iscpubs.com Maryland, on the campus of the Federation of Ameri- Advangene Consumables Inc. (AG) has the expertise American Biotechnology Laboratory will display recent can Societies for Experimental Biology. The Society's and innovation in the development and manufacture issues of the publication, which are free to qualified life purpose is to advance the science of biochemistry of plasticwares to fill the specific needs of the life science researchers. Each issue fieatures application and molecular biology through publication of scientific and educational journals (Journal of Biological Chem- science laboratories and testing industries. We have articles, descriptions of new products, and news items istry, Molecular and Cellular Proteomics, Journal of an impressive product profolio including surface for the life science industry sector. Lipid Research ), organization of scientific meetings, treated and collagen/poly-D- coated plates for advocacy for funding of basic research and education, cell culture and immuno assay, RNase/DNase free Alexander von Humboldt Foundation—Booth 147 support of science education at all levels, and promot- products for molecular biology applications, and high Fellowships Opportunities in Germany for ing the diversity of individuals entering the scientific performance plasticwares for general use. AG is com- Postdoctoral & Experienced Researchers workforce. mitted to providing high quality products that will boost your productivity, increase your accuracy and even AMERICAN SOCIETY FOR save you money. AMERICAN FRIENDS OF THE INVESTIGATIVE PATHOLOGY 231 ALEXANDER VON HUMBOLDT 9650 Rockville Pike ADVANTAGE BUSINESS MEDIA 1213 FOUNDATION 147 Bethesda, MD 20814 100 Enterprise Drive Suite 600 1012 14th Street NW, Suite 1015 Tel: 301-634-7130 Fax: 301-634-7990 Rockaway, NJ 07866 Washington, D.C., DC 20005 www.asip.org Tel: 202-783-1907 Fax: 202-783-1908 Tel: 973-920-7199 Fax: 973-920-7542 The American Society for Investigative Pathology is www.humboldt-foundation.de www.advnatagebusinessmedia.com a society of basic and clinical biomedical research Advantage Business Media – A leading publisher of American Friends of the Alexander von Humboldt scientists that investigate cellular and molecular information used by the scientific R&D community. Foundation, a nonprofit organization, promotes inter- mechanisms of disease. ASIP publishes the American Journals include: Bioscience Technology and Drug national scholarly exchange by publicizing the grants Journal of Pathology and the Journal of Molecular Discovery & Development, annual supplier directo- offered by the Alexander von Humboldt Foundation Diagnostics. Information about ASIP membership, ries, market or technology supplements, newsletters, (AvH). The AvH enables highly qualified scientists and meetings, and publications will be available. Internet-based publications and online trade shows. scholars of all disciplines and nationalities to carry out Free subscriptions are available. long-term research projects in Germany. AMG 725 AMERICAN PEPTIDE COMPANY 1243 18421 Bothell-Everett Hwy AGAROSE BEAD TECHNOLOGIES 449 Mill Creek, WA 98012 777 East Evelyn Avenue 5008 West Linebaugh Avenue, Suite 44 Tel: 425-368-2215 Fax: 425-398-0717 Sunnyvale, CA 94086 Tampa, FL 33634 www.advancedmicroscope.com Tel: 813-908-2589 Fax: 813-908-3190 Tel: 408-733-7604 Fax: 408-733-7603 www.americanpeptide.com AMG (Advanced Microscopy Group) focuses on www.abtbeads.com designing and developing innovative optical equip- American Peptide Company, Inc. (APC) offers com- Activated agarose beads including metal chelating ment for the life sciences market including biotechnol- prehensive selections of pre-manufactured catalog beads, glyoxal and aminoethyl beads, plain and cross- ogy research and diagnostic laboratories. Our product peptides in convenient aliquots, a spectrum of custom linked agarose beads. Also, Protein A conjugated line extends from traditional optical microscopes to agarose beads. synthesis services from array screens to mg and kg of research-grade peptides, and full-scale cGMP man- ergonomic, high resolution video and digital based ufacturing of pharmaceutical-grade peptides. APC is inspection systems with integrated high-definition ALA SCIENTIFIC INSTRUMENTS monitors, automated controls, and imaging software. INC. 353 dedicated to delivering high-quality peptides to phar- maceutical and biotech companies 1100 Shames Drive, Suite 110 ANASPEC, INC. 644 Westbury, NY 11590 AMERICAN QUALEX ANTIBODIES 2149 O'Toole Avenue Suite L Tel: 516-997-5780 Fax: 516-997-0528 SIGNAL TRANSDUCTION San Jose, CA 95133 www.alascience.com PRODUCTS 1115 Tel: 408-452-5055 Fax: 408-452-5059 ALA Scientific offers systems for complete environ- 920 A Calle Negocio www.anaspec.com mental control on the microscope stage, including our San Clemente, CA 92673 AnaSpec, Inc. is a leading provider of integrated pro- own devices for focal application, heating/cooling, and Tel: 949-492-8298 Fax: 949-492-6790 teomics solutions for worldwide life science research. solution exchange. We represent high-quality manu- www.iqualex.com With a vision for innovation through synergy, AnaSpec facturers of manipulators, microinjectors, and anti- Affinity Purified Antibodies, Monoclonals, Conjugates offers expertise in three primary technologies: pep- vibration tables, so that we can supply complete sys- Enzyme Fluorescent, Biotin, Streptavidin, Avidin, tides, detection reagents, and combinatorial chem- tems for all microinjection and fluorescence imaging Magnetic Beads, Signal Transduction Products, Flow, istry. applications. IFA/EM/Confocal, Chemiluminescence, ELISA, Immunohistochemistry. Custom Peptides, Antibodies. Attend the Exhibitor Showcase Monday, December 3, Room 206 1:45 pm-3:45 pm, Functional Assays, Apoptosis, Cytoxicity Capsase Detection, Multiplex Genotyping SNP Assays. Also attend the Tutorial: Antibody Development, Monday, December 3, Room 209A 6:00 pm-7:30 pm. Handouts are available at the booth!

185 EXHIBITORS The American Society for Cell Biology 47th Annual Meeting December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org

ANDOR TECHNOLOGY 1338 APPLIED PRECISION, LLC 1103 ASYLUM RESEARCH 815 425 Sullivan Avenue Suite 3 1040 12th Avenue N.W. 6310 Hollister Avenue South Windsor, CT 06074 Issaquah, WA 98027 Santa Barbara, CA 93117 Tel: 860-290-9211 Fax: 860-290-9566 Tel: 425-557-1000 Fax: 425-557-1055 Tel: 805-696-6466 Fax: 805-696-6444 www.andor.com www.appliedprecision.com www.asylumresearch.com Andor Technology provides digital camera and Applied Precision, LLC is a leading manufacturer in Asylum Research, a manufacturer of advanced microscopy imaging solutions including TE cooled, high-precision, high-resolution imaging products Atomic Force Microscopes (AFM), will feature the hard vacuum sealed CCD, ICCD & Electron Multi- including the DeltaVision® RT Image Restoration Sys- MFP-3D-BIO™that combines molecular-resolution plying CCD digital cameras with USB 2.0 connectivity tem for high-resolution live-cell microscopy imaging, imaging and high precision force-based measure- and dedicated software; spectroscopy systems, the arrayWoRx® family of multi-format imagers and ments for bioscience research. Advanced integrated accessories, and spinning disk confocal imaging microarray biochip readers, and the cellWoRx™ High optics are ideal for simultaneous AFM and optical microscopy systems and software to the world’s lead- Content Cell Analysis System. capabilities such as phase contrast, epifluorescence ing academic and research establishments. and confocal; Featured is the new iDrive for effortless ARCXIS BIOTECHNOLOGIES 1315 autotunes in liquid. APOGEE INSTRUMENTS, INC. 947 6920 Koll Center Parkway, Suite 215 1020 Sundown Way Suite 150 Pleasanton, CA 94566 ATCC 1142 Roseville, CA 95661 Tel: 925-461-1300 Fax: 925-265-9000 10801 University Boulevard Tel: 916-218-7450 Fax: 916-218-7451 www.Arcxis.com Manassas, VA 20110 www.ccd.com Arcxis Biotechnologies™ automates sample prepara- Tel: 703-365-2700 Fax: 703-365-2750 Apogee Instruments manufactures high performance tion for RNA and DNA to meet the demanding applica- www.atcc.org thermoelectrically cooled CCD imaging systems for a tions in today’s life sciences. The family of Lysix™ ATCC, the world’s largest biological resource center, wide range of life science / OEM applications. Sensors MPCs (micro-purification cards) and the Lysix™ supplies authenticated, genuine cell cultures which to 4096x4096. Low-cost Ascent Series cameras fea- Nucleic Acid Workstation 808 deliver reliable, repro- provide dependable and reproducible experimental ture 16-bit digitization with programmable speed and ducible, and economical sample preparation for opti- results. ATCC High-Performance Media and Sera are high speed USB2 interface (dual channel to 20 MHz). mized gene expression, sequence detection and gen- uniquely formulated to promote robust growth and Pricing and data sheets at http://www.ccd.com. otyping applications. reduce cell loss due to cryopreservation. Also avail- able from ATCC: Full-length MGC clones and safe APOLLO CYTOKINE RESEARCH 912 ARRYX, INC. 328 deposit services to protect valuable material. 120 Cristianitos Road Unit 11304 316 North Michigan Avenue Suite CL20 San Clemente, CA 92673 Chicago, IL 60601 AVEGENE LIFE SCIENCE 920 Tel: 949-369-6698 Fax: 949-272-3761 Tel: 312-726-6675 Fax: 312-726-6652 10F-1, No.81, Hsin Tai Wu Road, Sec. 1 www.apollocytokineresearch.com www.arryx.com Hsi Chih Taipei Hsien Taiwan, 221 R.O.C. Apollo Cytokine Research offers the world’s largest Arryx Inc is the leader in microscale manipulation and Tel: 011-886-2269-80369 Fax: 011-886-2269- range of human cell expressed (hcx) recombinant measurement using optical trapping. Employing real- 80368 human proteins mimicking natural protein due to time dynamic Holographic Optical Trapping (HOT), www.avegene.com human post-translational modifications. hcx proteins cells and other objects can be easlily held, manipu- Avegene Life Science, develops, manufactures and show different biological properties to non-human lated, sorted, or interogated in 3-dimensions on an markets a variety of biomedical instruments and expressed proteins due to correct protein folding, optical microscope platform. The waard-winning reagents that cover genomic, proteomic and diagnosis improved protein-protein interactions and stability, and BioRyx200 is the premiere commerical optical manip- applications. Besides, Avegene provides professional exposure of natural epitopes. ulation tool. OEM services from re-labeling OEM to fully custo- mized ODM. We produce what you really need by APPLIED BIOPHYSICS, INC. 1239 ASAHI SPECTRA USA INC. 1031 making it more efficient, more accurate, and more reli- 185 Jordan Road 23505 Crenshaw Blvd Suite 244 able. Troy, NY 12180 Torrance, CA 90505 Tel: 518-880-6860 Fax: 518-880-6865 Tel: 310-530-5855 Fax: 310-530-1739 AVES LAB, INC. 504 www.biophysics.com www.asahi-spectra.com 12571 SW Main Street Applied BioPhysics, manufactures an analytical Asahi Spectra supplies high-end optical filters and Tigard, OR 97223 instrument ECIS (Electric Cell-substrate Impedance instruments for biomedical optics, fluorescence Tel: 503-598-8766 Fax: 503-598-8746 Sensing). ECIS electrically monitors cell morphologi- microscopy, Raman research, lasers, lithography and www.aveslab.com cal changes providing quantitative, real time measure- astronomy. Our optical filters and instruments Aves Labs specializes in the production of custom ments of cell motility, attachment/spreading, and bar- enhance the measurement capabilities of UV, VIS, polyclonal antibodies using chickens as hosts. Our rier function, studies of cell-integrin interactions, meta- and NIR ranges. We design, develop, and manufac- services include peptide design and synthesis, anti- static invasion, signal transduction, cell migration, & ture advanced interference filters as well as optical peptide and anti-phosphopeptide antibody production, automated wound/healing, including wound/healing instruments. ELISA's, and affinity purification and labeling. We also under flow conditions. make secondary antibodies, immunoprecipitation, ASI/APPLIED SCIENTIFIC and blocking reagents. APPLIED BIOSYSTEMS 1328 INSTRUMENTATION 943 850 Lincoln Centre Drive M/S 432-4 29391 West Enid Road AVIVA SYSTEMS BIOLOGY 654 Foster City, CA 94404 Eugene, OR 97402 11180 Roselle Street, Suite 100 Tel: 650-554-2337 Fax: 650-638-5884 Tel: 541-461-8181 Fax: 541-461-4018 San Diego, CA 92121 www.appliedbiosystems.com www.asiimaging.com Tel: 858-433-8811 Fax: 858-552-6975 Applied Biosystems Group (NYSE:ABI), an Applera ASI manufactures top-of-the-line hardware for micro- www.avivasysbio.com Corporation business, develops and markets instru- positioning and microscope automation including Aviva Systems Biology is a five year old company ment-based systems, consumables, software, and closed-loop XYZ stages for ultra-precise positioning, focusing on gene transcription regulation research. services to the life science industry and research com- automated stages with integrated piezos for high ASB’s ChIP-GLAS technology allows analysis of all munity. Applied Biosystems offers innovative techno- speed ultra-precise Z stacks, laser feedback systems human and mouse promoters which interact with a logies that enable biological discoveries in basic for maintaining nanometer-scale positioning, high- particular transcription factor in a single experiment. research, pharmaceutical research and development, speed filterwheels and shuttering devices, and com- Additionally, ASB currently has over 1400 target-spe- and human and microbial identification. plete imaging systems. cific antibodies, releasing ~100 new antibodies/ month.

AXIS-SHIELD 904 PO Box 6863 Rodelokka Oslo 0566, 0504 Norway Tel: 011-47-2204-2000 Fax: 011-47-2270-0770 www.axis-shield.com Axis-Shield will display a range of Density Gradient Media for the isolation of biological particles using centrifugation techniques

186 The American Society for Cell Biology 47th Annual Meeting EXHIBITORS December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org

B-BRIDGE INTERNATIONAL, INC. 1049 BENJAMIN CUMMINGS 213 BIOFORCE NANOSCIENCES, INC. 612 320 Logue Avenue 1301 Sansome Street 1615 Golden Aspen Drive Suite 101 Mountain View, CA 94043 San Francisco, CA 94111 Ames, IA 50010 Tel: 650-969-7727 Fax: 650-969-7737 Tel: 415-402-2464 Fax: 415-402-2540 Tel: 515-233-8333 Fax: 515-233-8337 www.b-bridge.com www.aw-bc.com www.bioforcenano.com B-Bridge offers innovative research tools – easy and As the #1 college science publisher, Benjamin Cum- BioForce Nanosciences provides innovative and prac- accurate ELISA-based adipokine measurements, mings is dedicated to providing truly innovative and tical commercial products for applications in nanotech- ELISA -based biomarkers HGF and esRAGE, primary effective resources. Stop by booth #1515 to explore nology, with more than a decade of invention, research pre-adipocytes and pre-osteoclasts culture kits, the latest editions of Campbell/Reece Biology; Wat- and development of patented products. The core tech- apoptosis assays, and mechanical cell strain instru- son, Molecular Biology of the Gene; Becker, World of nology is the Nano eNabler™ , a Benchtop Molecular ments. Other products include antibodies, nucleic acid the Cell 6/e; Kleinsmith, Principles of Cancer Biology, Printer for precision liquid dispensing and surface pat- purification kits, transfection reagents, siRNA, CHO- and more. terning. The Nano eNabler™ includes a consumable binding protein purification kits, and more than 35 mil- line of print cartridges and chip surfaces. lion clones. BETHYL LABORATORIES, INC. 505 P.O. Box 850 BIOHIT, INC. 454 BAL-TEC, INC. 746 Montgomery, TX 77356 3535 Route 66, Building 4 27 Route 13 Tel: 800-597-6111 Fax: 866-597-6105 Neptune, NJ 07753 Brookline, NH 03033 www.bethyl.com Tel: 732-922-4900 Fax: 732-922-6621 Tel: 603-672-4060 Fax: 603-672-9618 Original manufacturer of polyclonal antibodies to intra- www.us.biohit.com www.bal-tec.com cellular proteins, phospho-specific proteins, serum Biohit will display state of the art, ergonomically Bal-Tec Inc will present Products for Electron Micros- proteins, secondaries, and more. Antibodies are designed hand-held electronic & manual pipettors, copy Preparation including new model High Pressure tested in various applications including ELISA, West- singe & multichannel formats; robotic pipetting module Freezing machine (HPM100), Products for Freeze ern Blot, immunoprecipitation, immunohistochemistry modules for OEM applications; disposable pipet tips; Fracture (BAF060); Vacuum-Cryo-transfer system and immunocytochemistry. ReliaBLOT–eliminates the microplate readers & washers; ELISA kits & mono- (VCT100; various table top evaporation and sputtering background commonly associated with Western Blots clonal antibodies; cryogenic storage vials. coating systems (MED020, SCD's, CED); critical point performed on immunoprecipitated proteins. Time sav- dryers (CPD's) and other cryo-prep equipment. ing Immunohistochemistry Accessory Kit, reagents for BIOLEGEND, INC. 606 immunostaining. 11080 Roselle Street BD BIOSCIENCES 1118 San Diego, CA 92121 10975 Torreyana Road BIOCHEMICAL JOURNAL 212 Tel: 858-455-9588 Fax: 858-455-9587 San Diego, CA 92121 Third Floor, Eagle House 16 Procter Street www.biolegend.com Tel: 858-812-8884 Fax: 858-812-3739 London, WC1V GNX UK BioLegend manufactures reagents for immunology www.bdbiosciences.com Tel: 011-44-207-280-4110 Fax: 011-44-207-280- and cell biology research. Fluorochrome conjugated BD, a leading global medical technology company 4169 antibodies include Pacific Blue, Alexa and tandem that makes and sells medical devices, instrumented www.portlandpress.com dyes. Novel antibodies: Treg (FOXP3, TSLP-R, systems and reagents, is dedicated to improving peo- The Biochemical Journal promotes international GITR), Innate Immunity (TLRs, NTB-A, CCR7), Cytok- ple’s health throughout the world. BD is focused on excellence in scholarly publishing in all aspects of ines/Chemokines (IL-17, IL-23, TSLP), Stem Cells improving drug therapy, enhancing the quality and biochemistry and molecular and cell biology and pro- (Nanog, FZD9, SOX-2, REX-1, FOXD3, FOXO3a); for speed of diagnosing infectious diseases, and advanc- vides a first-class publication vehicle for authors. FACS, ELISA, ELISPOT, IHC, IP, IF, and WB. ing research and discovery of new drugs and vac- cines. 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The buyer's guide includes detailed product your customer the products you need at the best scientific laboratories including Scienceware brand specifications, comparison capability, unbiased prices available. Biologix also serves as an OEM/Pri- plastic bottles, pitchers, cylinders and stirring bars, reviews, technology videos, and the latest news. Visit vate Label provider. wire and plastic racks and desiccator cabinets. our booth to signup for our informative e-mail newslet- Included in the line are numerous products for life ter, and receive a t-shirt and a chance to win an ipod. BIOLYPH LLC 1044 science laboratories. 1317 Fifth Street South BIOCON SCIENTIFIC 1450 Hopkins, MN 55343 BELLCO BIOTECHNOLOGY 1132 1397 Main Street Suite 3000 Tel: 952-936-0990 Fax: 952-936-0880 340 Edrudo Road Sanford, ME 04073 www.biolyph.com Vineland, NJ 08360 Tel: 207-324-4176 Fax: 207-490-5824 Biolyph converts IVD manufacturers’ unstable immu- Tel: 856-691-1075 Fax: 856-691-3247 www.bioconscientific.com nochemical and clinical chemistry reagents into stable www.bellcoglass.com BIOCON Scientific was founded in 1997 with a vision LyoSpheres™. LyoSpheres™ are microliter aliquots Bellco Biotechnology has been serving the market- of providing quality products with exceptional cus- of liquid that are lyophilized as precise and durable place for over fifty years. Products include Bioreactors tomer service - something that seems to be rapidly Spheres and packaged inside our customers’ stan- and accessories, Incubators, Spinner Flasks, Mag- disappearing from the marketplace. BIOCON Scien- dard or proprietary delivery devices. This capability netic Stirrers, Shakers, Roller Apparatus, Glassware, tific is a small but growing laboratory equipment and provides chemistry and delivery device options that Rockers, Hollow Fiber, Spinner Flask, BelloCell Dis- supplies distributor with an increasing national pres- have been previously unavailable. posable Bioreactors, and Plasticware. We are also ence. We take great pride in helping our customers in an authorized full line Corning Distributor. Visit our the selection process of buying laboratory equipment. BIOMATRICA, INC. 721 website at www.bellcoglass.com . Our specialists are well-trained and dedicated to help- 5627 Oberlin Drive Suite 120 ing our customers decide which products are right for San Diego, CA 92121 them and their budget. Tel: 858-550-0308 Fax: 858-678-0597 www.biomatrica.com Biomatrica, The Biostability Company, provides room temperature storage, shipping, and organizational solutions for laboratories managing and/or processing biological samples. Our products include a novel, dis- solvable polymer SampleMatrix, which is arrayed into multi-well plates or individual tubes, and SampleWare software for tracking samples.

187 EXHIBITORS The American Society for Cell Biology 47th Annual Meeting December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org

BIOMED CENTRAL 243 BIOTECHNIQUES 1130 BRANDTECH SCIENTIFIC, INC. 537 Middlesex House 34-42 Cleveland Street 52 Vanderbilt Avenue, 7th Floor 11 Bokum Road London, W1T 4LB UK New York, NY 10017 Essex, CT 06426 Tel: 011-44-207-631-9131 Fax: 011-44-207-631- Tel: 212-520-2771 Fax: 212-561-6629 Tel: 860-767-2562 Fax: 860-767-2563 9926 www.biotechniques.com www.brandtech.com www.biomedcentral.com Biotechniques®, the international journal of life sci- BrandTech will introduce its new pipette controller line, BioMed Central is the open access publisher commit- ence methods, is a highly respected publication of the accu-jet® pro, which includes a special pink ted to the free widespread dissemination of scientific peer-reviewed articles on laboratory methods. Known model. The company has announced a promotional research. BioMed Central publishes over 170 peer- for its editorial excellence, BioTechniques has over offer and a corporate donation to the National Breast reviewed open access journals, including BMC Cell 80,000 subscribers worldwide. The journal offers a Cancer Foundation in association with the product Biology. Visit the BioMed Central stand (#243) to learn balance of peer-reviewed content along with feature launch. BrandTech also offers pipettes dispensers, more about the journals and the benefits of open articles and topic-specific supplements. vacuum pumps, lab plastics and support jacks. access publishing. BIOTRUE INC. 633 BTX/HARVARD APPARATUS 547 BIOMOL 511 575 Market Street, Suite 2475 84 October Hill Road 5120 Butler Pike San Francisco, CA 94105 Holliston, MA 01746 Plymouth Meeting, PA 19462 Tel: 415-438-2662 Fax: 415-276-4759 Tel: 508-893-8999 Fax: 508-429-5732 Tel: 610-941-0430 Fax: 610-941-9252 www.biotrue.net www.btxonline.com www.biomol.com Biotrue develops software systems that enable bio- BTX has the widest range of electroporation and elec- Biomol is a leading producer of biochemicals with medical researchers to easily store, manage and trofusion products for InVitro and InVivo applications. applications in cell biology and signal transduction share all types of instrument and analytical datafiles. Among our newest innovations is the OneDrop Micro- research. Our catalog includes assays, enzymes, sub- Biotrue's solutions simplify search and retrieval, facili- Porator which allows for highly efficient transfection of strates, antibodies and inhibitors for the study of gene ate research collaboration and reduce the risk of data difficult cell lines. BTX also features the ECIS system regulation and chromatin, phosphorylation, ubiquitin/ loss, all through a web browser, so you can focus on which monitors real time cell migration, cell invasion proteasome, cytoskeleton and extracellular matrix, research rather than worry about data. and signal transduction. apoptosis and drug discovery. Order today . . . Dis- cover Tomorrow! BITPLANE, INC. 1325 C S BIO INC. 1410 620 Desnoyer Avenue 20 Kelly Court BIOPHOTONICS INTERNATIONAL 428 Saint Paul, MN 55104 Menlo Park, CA 94025 2 South Street Berkshire Common Tel: 888-332-4879 Fax: 866-691-9112 Tel: 650-322-1111 Fax: 650-322-2278 Pittsfield, MA 01201 www.bitplane.com www.csbio.com Tel: 413-499-0514 Fax: 413-442-3180 Bitplane specializes in 3D and 4D image visualization CS Bio is a biotechnology company that has been www.photonics.com/bio and analysis of microscope images. User can choose focused on providing peptide synthesizers and custom Biophotonics International magazine is designed for from a suite of seven software modules in an easy to peptides to the life sciences community for over 15 people who are using photonic technology in medical use yet extremely powerful software package that years. Our complete line of automated synthesizers or biotechnical products and procedures, and for key runs of 32bit and 64bit Windows PC and Macintosh can be found in laboratories from research organiza- researchers who are looking for new techniques and systems. Users can visualize, quantify, track objects tions to manufacturing facilities worldwide. CS Bio products to solve their problems. It is distributed free over time, analyze neurons, analyze colocalization, also features a full scale peptide production facility to those who use or apply photonics. perform deconvolution, and align images. with an emphasis on custom peptide and mid-scale cGMP manufacturing. BIOPLASTICS-CYCLERTEST 1414 BMG LABTECH, INC. 414 2933 South Miami Blvd Suite 121 2415 Presidential Drive, Suite 118 C TECHNOLOGIES, INC. 945 Durham, NC 27703 Durham, NC 27703 757 Route 202/206 Tel: 919-806-8811 Fax: 919-806-2014 Tel: 919-806-1735 Fax: 919-806-8526 Bridgewater, NJ 08807 www.bpcti.com www.bmglabtech.com Tel: 908-707-1009 Fax: 908-707-1030 Bioplastics/Cyclertest is uniquely positioned to assist BMG Labtech offers the most complete line of www.ctechnologiesinc.com with 2 of the key avaiables in PCR/qPCR, thermal microplate readers available. These have been C Technologies designs and manufactures Fiber Optic cycler temperatures dynamics, and PCR plastic dis- designed to provide you with comprehensive solutions Devices for UV/Vis analysis. Our latest device, Solo posables. 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Products Small Volume Delivery and Microperfusion Systems offered include SeaKem®, MetaPhor®, and for single cells and tissues. BOSTON ELECTRONICS NuSieve® Agarose, FlashGel™ System, PAGEr® CORPORATION 321 Precast Protein Gels, BioWhittaker™ Media and Sera, BIO-SYNTHESIS, INC. 825 91 Boylston Street Clonetics® Normal Human Cells and Media, Poie- 612 East Main Street Brookline, MA 02445 tics™ Differentiating Cell Systems, and unique BioAs- Lewisville, TX 75057 Tel: 800-347-5445 Fax: 617-731-0935 say Products and Services. We can help solve your Tel: 972-420-8505 Fax: 972-420-0442 www.boselec.com/products/sigtcspc.html research problems. www.biosyn.com FLIM (Fluorescence Lifetime Imaging Microscope) Bio-Synthesis provides synthetic peptides, antibodies, conversion of almost any microscope can be accom- PNA, bioconjugates, Custom DNA, RNA, LNA and plished using time correlated single photon counting other molecular biology services. Specializing in cus- (TCSPC) modules and confocal laser scanners from tom peptide synthesis from small to large scale we can Becker & Hickl GmbH (Berlin), available in North help you design the optimal peptides for you research America from Boston Electronics Corporation. FRET needs at the most competitive price nd the highest and FCS measurement, multispectral, and other multi- quyality. dimensional techniques fully supported.

188 The American Society for Cell Biology 47th Annual Meeting EXHIBITORS December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org

CAPRALOGICS, INC. 1347 CELL BIOLABS, INC. 1043 CELLASIC CORPORATION 313 P.O. Box 356, 235 Czeski Road 10225 Barnes Canyon Road Suite A103 2551 Merced Street Hardwick, MA 01037 San Diego, CA 92121 San Leandro, CA 94577 Tel: 413-477-6866 Fax: 413-643-0067 Tel: 858-625-0769 Fax: 858-453-2508 Tel: 510-895-1985 Fax: 510-895-1970 www.capralogics.com www.cellbiolabs.com www.cellasic.com Capralogics is a full service polyclonal antibody pro- Cell Biolabs, Inc. develops innovative research prod- CellASIC Corporation specializes in microfluidic duction facility, dedicated to providing quality poly- ucts in the areas of cell-based assays, viral expres- instrumentation for live cell imaging. Our systems are clonal antibody services for diagnostic, research, and sion, oxidative stress and cytoskeleton regulation. designed to be operated with standard inverted micro- discovery applications. Capralogics has the country's Examples include assay kits for cell migration/inva- scopes to give the user superior control over the cell first USDA Certified "Scrapie Free" goat flock dedi- sion/transformation, small GTPase activation, and culture environment during time lapse experimenta- cated for large volume antibody production. We offer DNA/protein/lipid oxidation. We also supply premade tion. Our microfluidic technology enables precise flow GLP assurances with complete traceability of animals adenoviruses and reagents for virus purification, titer exchange kinetics with unsurpassed optical clarity. and materials. Capralogics is an OLAW compliant and and transduction. Come see how CellASIC is redefining live cell experi- USDA licensed facility with EC1774/2002 approval to mentation. export ruminant serum to EU countries. CELL KINETICS, LTD. 1015 Yodfat 2, Global Park CELPROGEN, INC. 445 CARL ZEISS MICROIMAGING, INC. 409 Lod, 71291 Israel 1871 North Gaffey Street Suite A&B One Zeiss Drive Tel: 011-972-8-9188-622 Fax: 011-972-8-9185-008 San Pedro, CA 90731 Thornwood, NY 10594 www.medistechnologies.com Tel: 310-547-3975 Fax: 310-547-2975 Tel: 800-233-2343 Fax: 914-681-7445 Cell Kinetics CellChip enables simultaneous capture, www.celprogen.com www.zeiss.com/micro maintenance and monitoring of up to 10,000 adherent Celprogen is a Stem Cell & Cell Biology Research Visit the Zeiss booth to see the next revolution in wide- or non-adherent living cells, each held in a micron-size Biotechnology Company focusing in stem cell differen- field research microscopy, groundbreaking technol- well. 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Also shown: tom tissue culture Medium and generation od stable Zeiss AxioVision, new release for high speed image CELL PRESS 208 cell lines with specific over expression of genes. acquisition with High Speed AxioCam HS digital cam- 600 Technology Square 5th Floor Recombinant proteins, polycolonal & monoclonal anti- era, Deconvolution; ApoTome 3D optical sectioning; Cambridge, MA 02139 bodies. Stem cell kits, and cancer stem cell kits, pri- PALM Laser Microdissection with Automatic Object Tel: 617-661-7057 Fax: 617-661-7061 mary and established cell line tissue culture kit. Find/Cut and, Cellomics High-Content Screening. www.cellpress.com Cell Press publishes highly cited, cutting-edge CENTER FOR COMPUTER CARL ZEISS SMT INC. 753 research across the broad spectrum of life sciences, INTEGRATED SYSTEMS FOR One Corporation Way with each title viewed as a must-read by the scientific MICROSCOPY AND Peabody, MA 01960 community it serves. Visit our booth for sample copies MANIPULATION (CISMM) 128 Tel: 978-826-7903 Fax: 978-532-5696 of Cell, Developmental Cell, Neuron, Current Biology, University of North Carolina, CB#3255 www.smt.zeiss.com and our newest journal, Cell Stem Cell. Chapel Hill, NC 27599-3255 Carl Zeiss SMT raises the bar with the new Supra, high Tel: 919-962-4057 Fax: 919-843-7308 resolution field emission SEM’s offering outstanding CELL SCIENCES, INC. 1029 www.cs.unc.edu/cismm resolution, plus variable pressure allowing low KV 480 Neponset Street Building 12A UNC-Chapel Hill's center for Computer-Integrated imaging on uncoated samples. In addition, the new Canton, MA 02021 Systems for Microscopy and Manipulation (CISMM) FIB Crossbeam permits live e-beam imaging while Tel: 781-828-0610 Fax: 781-828-0542 develops novel force microscopy equipment, tech- FIB milling; an ideal tool for failure analysis and TEM www.cellsciences.com niques, and supporting computer visualization and sample prep. Cell Sciences offers immunochemicals for life science analysis tools. A growing suite of CISMM developed research. Recombinant cytokines, cytokine receptors, software is available for free download. CISMM is an CAYMAN CHEMICAL COMPANY 424 chemokines, kinases, phosphatases, ELISA and NIH Research Resource funded through NIBIB. 1180 East Ellsworth Road ELISPOT kits, monoclonal and polyclonal antibodies, Ann Arbor, MI 48108 and matched antibody pairs for do-it-yourself ELISA CHROMA TECHNOLOGY Tel: 734-971-3335 Fax: 734-971-3420 and ELISPOT assays are available.. 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189 EXHIBITORS The American Society for Cell Biology 47th Annual Meeting December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org

CINCINNATI CHILDREN'S COOLLED LTD 1045 COVANCE RESEARCH PRODUCTS 910 RESEARCH FOUNDATION 149 CIL House Charlton Road PO Box 7200 3333 Burnet Avenue (VP-2) Andover, SP10 3JL UK Denver, PA 17517 Cincinnati, OH 45229 Tel: 1-800-877-0128 Fax: 011-44-1264-321329 Tel: 717-336-4921 Fax: 717-336-5344 Tel: 513-636-1197 Fax: 513-636-2066 www.precisexcite.com www.crpinc.com www.cincinnatichildrens.org Coolled manufactures precisExcite - the LED excita- Covance provides innovative antibody products and Cincinnati Children’s Hospital Medical Center is dedi- tion source for fluorescence microscopy. precisExcite a full range of immunology services. Our catalog fea- cated to serving the health care needs of infants, chil- provides stability, homogeneity and control . Simple tures a large collection of cell type-specific marker dren and adolescents and is one of the nation's top to use. Instant on/off. 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COOPERATIVE HUMAN TISSUE CLONTECH LABORATORIES, INC. 804 NETWORK 1012 CRI, INC. 433 1290 Terra Bella Avenue 9207 Jackson Street 35-B Cabot Road Mountain View, CA 94043 Mentor, OH 44060 Woburn, MA 01801 Tel: 650-919-7300 Fax: 650-424-1352 Tel: 440-974-0569 Fax: 440-974-0091 Tel: 781-935-9099 Fax: 781-935-3388 www.clontech.com www-chtn.ims.nci.nih.gov www.cri-inc.com Clontech Laboratories, Inc. develops and supplies The CHTN is a non-profit organization funded by the CRI, Inc. (Cambridge Research and Instrumentation, innovative kits, reagents and services with applica- National Cancer Instittute to provide remnant human Inc.) develops and manufacturers high-performance tions for gene discovery, regulation and function; pro- biospecimens to IRB-approved researchers. 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COLD SPRING HARBOR CVI MELLES GRIOT 319 LABORATORY PRESS 205 CORIELL CELL REPOSITORIES 111 2051 Palomar Airport Road 200 500 Sunnyside Blvd 403 Haddon Avenue Carlsbad, CA 92011 Woodbury, NY 11797 Camden, NJ 08103 Tel: 760-438-2131 Fax: 760-438-5208 Tel: 516-422-4100 Fax: 516-422-4097 Tel: 856-757-4822 Fax: 856-757-9737 www.cvimellesgriot.com www.cshlpress.com ccr.coriell.org CVI Melles Griot is a leading manufacturer of solid- Featured books include: The Condensed Protocols The Coriell Cell Repositories distribute well-character- state, diode and gas laser technologies. Over 36 From Molecular Cloning: A Laboratory Manual (Sam- ized cell cultures and DNA samples including a wide wavelengths from the UV to the NIR in single, multiple brook and Russell); DNA Replication and Human Dis- variety of inherited diseases and chromosomal aber- or tunable wavelength outputs to coincide with your ease (DePamphilis); Translational Control in Biology rations, human/rodent somatic cell hybrids, CEPH fluorophores and samples. Ideal for imaging, fluores- and Medicine (Sonenberg, Hershey, and Mathews); families, human variation collections, HapMap sam- cence induced and metrologic applications as cytome- Epigenetics (Allis, Jenuwein, and Reinberg); Binding ples and non-human primates. Collections are spon- try, microscopy, sequencing and particle characteriza- & Kinetics for Molecular Biologists (Goodrich and sored by the NIGMS, NIA, NINDS, NHGRI, ADA, NSF tion. Kugel); Experimental Design for Biologists (Glass). and other institutions. 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For www.cookecorp.com Cosmo Bio is a Japanese distributor of life science example, Rho family reagents, kits and proteins for Cooke provides scientific high performance and high products and has been active in the Japanese market research, diagnostic and drug discovery applications. speed 12, 14 and 16 bit digital CCD, ICCD, emCCD for over 20 years. We specialize in distributing all kinds Also, we provide highly active preparations of pure and CMOS camera systems. The cameras are ideal of products from around the world to Japan, as well tubulin, actin and kits to assay those proteins. All pro- for studies of live processes using Ca imaging, time as selling products from our manufacturers in Japan teins and kits are highly quality controled to allow you lapse microscopy, FRET/FRAP, TIRF and chemolum- to the rest of the world. to perform reproducible experiments year after year. inescence/bioluminescence techniques. Cooke is a technology leader in high SNR quantitative imaging. COVALYS BIOSCIENCES AG 311 DATAWORKS DEVELOPMENT, INC. 1310 Benkenstrasse 254 P.O. Box 174 Witterswil, CH 4108 Switzerland Mountlake Terrace, WA 98043 Tel: 011-41-6172-52050 Fax: 011-41-6172-52055 Tel: 425-673-1974 Fax: 425-673-2506 www.covalys.com www.freezerworks.com Covalys offers the SNAP-tag and ACP-tag for specific Provider of sample management software for clinical covalent protein labeling in live cells or in solution, and research laboratories since 1985. Developers of and for immobilization of proteins. These can be used Freezerworks™ 5 and Freezerworks Unlimited as an alternative to fluorescent proteins, to develop freezer inventory software. Tracks samples across robust binding assays and for pull down experiments. multiple freezers, safeguarded by powerful data secu- Kits include a free license for commercial use. rity, 21 CFR part 11 compliance, and cryogenic-safe bar code vial labeling. For all freezers and tanks.

190 The American Society for Cell Biology 47th Annual Meeting EXHIBITORS December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org

DIAGNOSTIC INSTRUMENTS,INC. 553 DRUMMOND SCIENTIFIC 1128 ELSEVIER 210 6540 Burroughs Street 500 Parkway 360 Park Avenue South Sterling Heights, MI 48314 Broomall, PA 19008 New York, NY 10010 Tel: 586-731-6000 Fax: 586-731-6469 Tel: 800-523-7480 Fax: 610-353-6204 Tel: 212-989-5800 Fax: 212-633-3990 www.diaginc.com www.drummondsci.com www.elsevier.com Diagnostic Instruments is a manufacturer of SPOT™ Drummond Scientific, a manufacturer of liquid han- Elsevier presents new levels of depth and dimension scientific grade Digital Cameras and SPOT™ Imaging dling devices is demonstrating our new ergonomic with important books at 10-20% meeting discount software. SPOT camera systems find application in a Pipet-Aid XL, targeted for use in the biosafety hood. prices and top-level journals like Trends in Cell Biol- range from high-speed, low light applications, through This unit will reduce strain in the neck, shoulder and ogy. 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Box 341232 www.empix.com tomers to improve research productivity and effective- Bethesda, MD 20827 Empix Imaging Inc. is a leading developer of image ness, thus accelerating the discovery and Tel: 800-338-6835 Fax: 301-340-0582 analysis and processing software designed for scien- development of new drugs. www.edvotek.com tific or industrial applications used for acquisition, pro- Edvotek manufactures and supports the most cessing, analysis and deconvolution supporting DNASTAR, INC. 811 affordable, comprehensive, and student-friendly offer- imaging hardware, CCD's framegrabbers, TTL&I/O 3801 Regent Street ing of biotechnology education experiment kits and devices, microscopes and peripherals. A digital cam- Madison, WI 53705 equipment available. era SDK is available. Clients include universities, hos- Tel: 608-258-7420 Fax: 608-258-7439 pitals, biotech and worldwide. www.dnastar.com ELECTRON MICROSCOPY Dnastar, an early bioinformatics company, makes SCIENCES/DIATOME U.S. 719 EPITOMICS, INC. 613 Lasergene DNA & protein sequence analysis software 1560 Industry Road 863 Mitten Road Suite 103 for both Windows and Macintosh computers, including Hatfield, PA 19440 Burlingame, CA 94010 running natively on Mac Intels. Just released Tel: 215-412-8400 Fax: 215-412-8450 Tel: 650-583-6688 Fax: 650-583-6680 Lasergene 7.1 features SeqMan Pro, able to quickly www.emsdiasum.com www.epitomics.com assemble tens of thousands of sequences. Get a free Electron Microscopy Sciences will have on display Epitomics, Inc. utilizes a unique and proprietary Rabbit trial version at our booth. there complete line of chemicals. accessories, sup- Monoclonal Antibody (RabMab) technology to pro- plies, and equipment for all fields of microscopy and duces high quality antibodies and develops an DOJINDO MOLECULAR general research incluidng ImmunoGold Reagents, enabling platform to use RabMAbs in the broad areas TECHNOLOGIES, INC. 1355 Tissue sectioners, Tissue Processors and Microwave of research, diagnostics and therapeutics. 211 Perry Parkway, Suite 5 ovens Diatome will have on display there complete Gaithersburg, MD 20877 line of Diamond knives for the sectioning of all types EPPENDORF NORTH AMERICA 552 Tel: 301-987-2667 Fax: 301-987-2687 of samples at room and cryo temperatures at a variety One Cantiague Road www.dojindo.com of inclination angles for thick as well as thin sectioning. Westbury, NY 11590 Dojindo is a reagent manufacturing company focusing Tel: 516-334-7500 Fax: 516-334-7521 on research in the fields of Molecular Biology and www.eppendorf.com Biochemistry. We offer easy-to-use kits for cytotoxicity Eppendorf is continually expanding its product offering assay, antibody labeling, DNA damage detection, and currently offers cell biology and molecular biology SOD assay, glutathione assay and nitric oxide products. Products include micromanipulation/micro- research. injection instrumentation and disposables, sample preparation instruments and consumables, centrifu- gation and liquid handling devices plus instruments licensed for PCR. Eppendorf focuses on providing system solutions and services to accommodate cus- tomer needs.

191 EXHIBITORS The American Society for Cell Biology 47th Annual Meeting December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org

ESSEN INSTRUMENTS 1146 FABGENNIX INTERNATIONAL. INC. 946 FINNZYMES 1129 1156 Oak Valley Drive 5850 Town and Country Blvd Suite 301 800 West Cummings Park, Suite 5550 Ann Arbor, MI 48108 Frisco, TX 75034 Woburn, MA 01801 Tel: 734-769-1600 Fax: 734-769-7295 Tel: 214-387-8105 Fax: 214-387-0870 Tel: 800-993-1283 Fax: 617-245-1962 www.essen-instruments.com www.fabgennix.com www.finnzymes.fi Essen specializes in cell-based assay equipment and FabGennix International Inc., provides high quality Finnzymes specializes in reagents and instrumenta- is recognized as one of the leading Innovators in pre- (Gold-label)custom and catalog antibodies to biomed- tion for high performance PCR. Our products include clinical drug discovery instrumentation platforms. We ical research communities. We specialize in making PhusionTM high-fidelity polymerase, as well as kits are proud to introduce our newest cell-based imaging cusotm antibodies to phospho-, methylated, sulfated for real-time PCR, mutagenesis, cDNA synthesis and system -IncuCyte. This system generates time-lapse and acetylated antigenic determinants in various RNAi production. Our new PikoTM thermal cycler images in addition to providing non-invasive kinetic hosts. delivers extremely fast, accurate, and inexpensive growth curves. Both Phase & Fluorescence capabili- thermal cycling utilizing our novel SlidetiterTM line of ties are available. 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192 The American Society for Cell Biology 47th Annual Meeting EXHIBITORS December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org

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193 EXHIBITORS The American Society for Cell Biology 47th Annual Meeting December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org

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194 The American Society for Cell Biology 47th Annual Meeting EXHIBITORS December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org

JACKSON IMMUNORESEARCH KEMP BIOTECHNOLOGIES 126 LATHROP ENGINEERING INC 915 LABORATORIES, INC. 502 7307 Governors Way 1101 South Winchester Blvd, B110 872 West Baltimore Pike P.O. Box 9 Frederick, MD 21704 San Jose, CA 95128 West Grove, PA 19390 Tel: 301-620-7100 Fax: 301-620-0162 Tel: 408-260-2111 Fax: 408-260-2242 Tel: 800-367-5296 Fax: 610-869-0171 www.kempbiotech.com www.lathropengineering.com www.jacksonimmuno.com Since 1992, Kemp Biotechnologies has supported the Lathrop is a full service product development organi- Affinity-purified secondary antibodies (many adsorbed research of public and private sector laboratories by zation. From concept to pre-production prototypes and against other species for multiple labeling), new anti- providing expertise in cell culture, protein expression, manufacturing transfer, we have expertise in microflui- mouse IgG subclass specific, new anti-IgG light chain and protein purification on a contract basis. 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195 EXHIBITORS The American Society for Cell Biology 47th Annual Meeting December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org

LIFECORE BIOMEDICAL, INC. 331 LSM TECHNOLOGIES, INC. 122 MBF BIOSCIENCE- 3515 Lyman Blvd 18 South Main Street, Suite 110 MICROBRIGHTFIELD 1326 Chaska, MN 55318 Stewartstown, PA 17363 185 Allen Brook Lane, Suite 101 Tel: 952-368-6321 Fax: 952-368-4278 Tel: 717-993-0191 Fax: 717-993-0193 Williston, VT 05495 www.lifecore.com www.lsmtech.com Tel: 802-288-9290 Fax: 802-288-9002 Lifecore’s hyaluronan is a component in several com- LSM Technologies, Inc. provides a series of products, www.mbfbioscience.com mercial ophthalmic, orthopedic, and veterinary medi- upgrades and service contracts for confocal laser MBF Bioscience provides researchers with micro- cal products. Lifecore supplies customers with either scanning microscopes. Our laser, optical, and com- scope integrated stereology systems and solutions for hyaluronan or finished products manufactured in its puter upgrades enhance your microscope to take in-situ cell counting, volume measurement and fiber ISO 13485 and FDA certified aseptic filling facility. In advantage of the latest developments in microscopy. density estimation as well as expert advice for experi- addition, Lifecore’s hyaluronan is supplied to aca- Some of our products include non-descanned detec- mental preparation. The trusted source for imaging demic and corporate researchers around the world tors, objective inverters, and sensitive and quiet systems, installation and training for 20 years. for basic science and product development research. cooled PMTs. MEDIA CYBERNETICS 622 LIFELINE CELL TECHNOLOGY 1251 LUDL ELECTRONIC PRODUCTS 4340 East-West Highway Suite 400 10 East Frederick Street LTD. 422 Bethesda, MD 20814 Walkersville, MD 21793 171 Brady Avenue Tel: 301-495-3305 Fax: 301-495-5964 Tel: 301-845-7787 Fax: 301-845-2405 Hawthorne, NY 10532 www.mediacy.com www.lifelinecelltech.com Tel: 914-769-6010 Fax: 914-769-4759 Media Cybernetics helps researchers extract knowl- Lifeline Cell Technology manufactures and distributes www.ludl.com edge from images through world-renowned software human cells and serum-free media systems that are Ludl Electronic Products is the premier designer and for image capture, processing, analysis and manage- quality-tested, consistent and affordable as products manufacturer of microscope automation components. ment. Our flagship software, Image-Pro Plus for research use. Specialties: human stem cell sys- Products include motorized XY stages, robotic speci- increases accuracy and automates research pro- tems; fully-differentiated normal human cells; opti- men handling, focus controls, filter wheels and illumi- cesses. We also offer InVivo Analyzer for live cell mized media. Come see our new human endothelial nation systems. Whether the application utilizes stan- imaging, IQbase image database, and AutoDeblur & cell products! Custom media Formulation and special- dard products or custom designed alternatives, we AutoVisualize for deconvolution and 3D visualization. ized media packaging solutions are also available. offer the highest possible performance, quality and customer service. MEDIATECH, INC. 1319 LIFESENSORS, INC. 922 13884 Park Center Road 271 Great Valley Parkway LUMENERA CORPORATION 728 Herndon, VA 20171 Malvern, PA 19355 782 Everton Way Tel: 703-471-5955 Fax: 703-467-9851 Tel: 610-644-8845 Fax: 610-644-8616 Ottawa, ON K2E 8A7 Canada www.cellgro.com www.lifesensors.com Tel: 613-736-4077 Fax: 613-736-4071 Mediatech is a manufacturer and distributor of sterile LifeSensors products focus on ubiquitin-like proteins www.lumenera.com cell culture media, salt solutions, antibiotics, supple- and deubiquitinases (DUBs). We offer 1) innovative Lumenera is a leading developer/manufacturer of ments and reagents, custom formulations, molecular technologies for increasing functional recombinant high-performance USB 2.0 digital cameras and cus- biology reagents, animal sera use in conjunction with protein production in both prokaryotic and eukaryotic tom imaging solutions for scientific and industrial IVD applications and cellular therapies and bioprocess hosts, 2) proteins, antibodies, and kits for detecting applications. Lumenera’s cameras are used world- containment systems. and analyzing DUB activities in various systems, and wide in a diverse range of microscopy and OEM 3) custom protein production and assay develop- designs. Visit us to learn more about our new Large MICROBIOLOGY INTERNATIONAL 748 ment services. Format Sensor cameras and Infinity Analyze software. 5108 Pegasus Court Suite A Frederick, MD 21704 LIGHTFORM, INC. 813 MAG BIOSYSTEMS 523 Tel: 301-662-6835 Fax: 301-662-8096 601 Route 206, Suite 26-479 3440 Britannia Drive, Suite 100 www.800ezmicro.com Hillsborouogh, NJ 08844 Tudson, AZ 85706 Microbiology International carries a complete line of Tel: 908-281-9098 Fax: 908-904-1067 Tel: 520-889-9933 Fax: 520-844-1099 automated laboratory products and will be featuring: www.lightforminc.com www.magbiosystems.com the Systec range of media preparators; the Combijet LightForm will demonstrate the PARISS® Analytical MAG Biosystems is dedicated to meeting the growing plate pourer, capable of deep dish pouring; the MD8 Hyperspectral Imaging system. Generate spectral top- need for innovative, complete biological imaging solu- air sampler; and the ProtoCOL automatic colony ographic maps of live and prepared samples over an tions. Our Lumazone system is a fully integrated labo- counter. Visit Booth #748 to see these products. unlimited FOV. Captures all wavelengths simultane- ratory solution designed for quantitative chemilumi- ously between 365 and 920 nm with no overlapping nescence and fluorescence macroscopic imaging of MID-ATLANTIC, INC. 140 orders. See also the MIDL spectral calibration lamp a variety of samples, including whole plants and ani- 77 Elbo Lane for confocal and non-confocal wavelength calibration. mals. Our new SpecEM offers full-spectrum imaging Mt. Laurel, NJ 08055 and dual-channel collection capabilities. It is ideal for Tel: 856-762-2000 Fax: 856-762-2010 LONZA (FORMERLY CAMBREX applications such as the separation of specific fluores- www.midatlanticdiagnostics.com RESEARCH PRODUCTS) 105 cence from autofluorescence. Mid-Atlantic Diagnostics, Inc. demonstrates Multipur- 8830 Biggs Ford Road pose Stem Cell Workstation. LAF Hood, Heated Work Walkersville, MD 21793 MARINE BIOLOGICAL Surface, Built In Stereo Microscope & Incubator, Gas Tel: 301-898-7025 Fax: 301-845-7900 LABORATORY (MBL) 246 Ports, Drop Leaf for Inverted Microscope w/ Micro- www.lonza.com 7 MBL Street manipulators. Providing cells a controlled microenvi- Lonza , formerly Cambrex Research Products, pro- Woods Hole, MA 02543 ronment for safer handling. Also Introducing “Egg- vides innovative, reliable products and services for cell Tel: 508-289-7423 Fax: 508-289-7934 zyter”, a patented disposable Microelectrode for eas- culture, cell biology, and molecular biology. Products www.mbl.edu ier cell electrofusion and activation. offered include SeaKem®, MetaPhor®, and Founded in 1888, the Marine Biological Laboratory NuSieve® Agarose, FlashGel™ System, PAGEr® (MBL®) is a leading international, independent, non- MILLIPORE 437 Precast Protein Gels, BioWhittaker™ Media and Sera, profit institution dedicated to discovery and to improv- 290 Concord Road Clonetics® Normal Human Cells and Media, Poie- ing the human condition through creative research Billerica, MA 01821 tics™ Differentiating Cell Systems, and unique BioAs- and education in the biological, biomedical and envi- Tel: 800-645-5476 Fax: 978-715-1393 say Products and Services. We can help solve your ronmental sciences. For more information about www.millipore.com research problems. research, education, and conferencing opportuni- Millipore will present the new Milli-Q Advantage Water ties: www.MBL.edu. Purification System with convenient dispensing options for ultrapure water. Also new, the expanded line of Millicell Cell Culture Inserts and Plates will be on display as well as the complete line of products for sterile filtration, western blotting and protein con- centration.

196 The American Society for Cell Biology 47th Annual Meeting EXHIBITORS December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org

MILTENYI BIOTEC, INC. 1211 MOLECULAR MACHINES & NANOPROBES, INC. 1241 12740 Earhart Avenue INDUSTRIES 1337 95 Horseblock Road, Unit 1 Auburn, CA 95602 P.O. Box 6392 Yaphank, NY 11980 Tel: 530-887-5390 Fax: 530-745-2890 Manchester, NH 03108 Tel: 631-205-9490 Fax: 631-205-9493 www.miltenyibiotec.com Tel: 603-639-9536 Fax: 603-978-0304 www.nanoprobes.com Miltenyi Biotec provides products and services for pur- www.molecular-machines.com Nanoprobes offers labeling and detection reagents for suing life science research. Based on MACS® Tech- MMI Inc. is a leading manufacturer of laser optical electron microscopy, light microscopy, western blot- nology, the portfolio includes over 600 products for the instruments such as laser microdissection and optical ting and immunoblotting. Products include Nanogold separation, cultivation, flow cytometric and molecular tweezers. The Cell Cut and SmartCut are professional labeling reagents and conjugates, combined fluores- analysis of cells. The MACSmolecular business unit tools for microdissection of single cells and gourps cent and gold probes, silver and gold enhancers. Our offers innovative solutions for molecular biology of cell from paraffin samples, cryo samples, smears, new product, EnzMet, is a novel, highly sensitive and research, comprehensive microarray service, and cytospins, and cell bulture. specific staining reagent for in situ hybridization and microarray hybridization instrumentation. immunohisochemistry. MWG BIOTECH, INC. 249 MIRUS BIO CORPORATION 942 4191 Mendenhall Oaks Parkway NATIONAL CENTER FOR 505 South Rosa Road High Point, NC 27265 BIOTECHNOLOGY INFORMATION 119 Madison, WI 53719 Tel: 336-812-9995 Fax: 336-812-9983 8600 Rockville Pike, 38A, 3rd Floor Tel: 608-441-2852 Fax: 608-441-2849 www.mwg-biotech.com Bethesda, MD 20894 www.mirusbio.com MWG is a genomic company that manufactures high Tel: 301-496-2475 Fax: 301-480-9241 Mirus Bio provides state-of-the-art reagents for nucleic quality oligonucleotides, gene synthesis, and per- www.ncbi.nlm.nih.gov acid delivery and labeling. TransIT® products provide forms DNA sequencing services for the life science NCBI provides integrated access to DNA and protein high efficiency transfection in a range of cell types market. Whether you are looking for basic DNA or sequence data, associated mapping data, protein and applications, including siRNA delivery. Label IT® RNA synthesis, complex gene, 24 hr high quality DNA structures, and MEDLINE. Demonstrations of the products offer non-enzymatic labeling for use in sequencing service, or next generation sequencing, GenBank database, the retrieval system, tracking, hybridization and microarray applications, MWG can fulfill your needs! PubMed for MEDLINE searching, BLAST and VAST including miRNA. www.mirusbio.com similarity searches for sequence and structures, and NANODROP TECHNOLOGIES, INC. 330 the BankIt and Sequin sequence submission software MITOSCIENCES, INC. 1348 3411 Silverside Road will be provided. 1850 Millrace Drive, Suite 3A Bancroft Building Eugene, OR 97403 Wilmington, DE 19810 NATIONAL EYE INSTITUTE 1114 Tel: 541-284-1800 Fax: 541-284-1801 Tel: 302-479-7707 Fax: 302-792-7155 5635 Fishers Lane, Suite 1300 MSC 9300 www.mitosciences.com www.nanodrop.com Bethesda, MD 20892 Developers of monoclonal antibodies and immunoas- NanoDrop Technologies manufactures and sells pho- Tel: 301-451-2020 Fax: 301-402-0528 says that support research into mitochondrial proteins tometric instruments specifically designed for 1ul sam- www.nei.nih.gov and other proteins involved in metabolism. Offer a ples, employing a patented retention system that elim- The National Eye Institute (NEI) is a component of broad portfolio of products for studying apoptosis, Par- inates the need for cuvettes and capillaries. Using this the National Institutes of Health, one of the agencies kinson's and Alzheimer's Diseases, cancer, oxidative system, the NanoDrop®’ND-1000 Spectrophotometer within the Department of the U.S. Health and Human stress, and a variety of metabolic disorders. Devel- enables full UV-Vis absorbance analysis and the Services. NEI supports basic and clinical research, oping multiplexing assays for several suspension and NanoDrop®’ND-3300 Fluorospectrometer provides research training, career development, and research planar array platforms. fluorescence emission spectra analysis. resources in all aspects of vision science and visual neuroscience employing a wide range of funding MO BIO LABORATORIES 1014 NANONICS IMAGING LTD. 944 mechanisms for those interested in seeking support. 2746 Loker Avenue West Manhat Technology Park, Malcha Please visit our booth (1114) to learn more about fund- Carlsbad, CA 92010 Jerusalem, 91487 Israel ing opportunities in vision research. Tel: 760-929-9911 x118 Fax: 760-929-0109 Tel: 011-972-2-678-9573 Fax: 011-972-2-648-0827 www.mobio.com www.nanonics.co.il NATIONAL INSTITUTE OF ALLERGY Mo Bio offers a complete line of nucleic acid extraction Environmentally controlled scanned probe micros- AND INFECTIOUS DISEASES 247 and purification kits. Guaranteed, all kits for DNA/RNA copy (AFM/NSOM/SPM) systems offering ultimate 10401 Fernwood Road isolation from a variety of sample sources such as resolution and integration with any optical microscope Fernwood Bldg., 2SE61 bacteria, tissue, plasmid, and others. Mini, Midi, Maxi including differential interference contrast. NSOM cel- Bethesda, MD 20892 and 96 well formats. Laboratory Services offer testing lular imaging in physiological media with detail greater Tel: 1-888-798-4991 Fax: 301-480-1599 and certification programs for bioburden, sterilization, than AFM; Zepto liter volume pH measurements; 1000 www3.niaid.nih.gov/ endotoxin free, DNase free, RNase free, and more. times greater FCS sensitivity with NSOM, on-line The National Institute of Allergy and Infectious Dis- AFM/Raman/fluorescence chemical imaging, on-line eases (NIAID) conducts and supports basic and MOLECULAR DEVICES, NOW PART electron microscopic imaging, and nanometric AFM applied research to better understand, treat, and ulti- OF MDS ANALYTICAL controlled protein printing. Also unique, singular force mately prevent infectious, immunologic, and allergic TECHNOLOGIES 1203 sensing patch clamping and electrochemical micros- diseases. NIAID research has led to new therapies, 1311 Orleans Drive copy systems. vaccines, diagnostic tests, and other technologies that Sunnyvale, CA 94089 have improved the health of millions of people. Tel: 408-747-3534 Fax: 408-747-3602 NANOPOINT, INC. 949 www.moleculardevices.com 900 Fort Street Mall, Suite A20 NATIONAL INSTITUTE OF CHILD Molecular Devices’ introduces an integrated imaging Honolulu, HI 96813 HEALTH AND HUMAN solution for high-content screening which consists of Tel: 808-457-1145 Fax: 808-537-4245 DEVELOPMENT (NICHD) 133 a new, cost-effective imaging platform, ImageXpress www.nanopointimaging.com 31 Center Drive, Room 2A31 Micro™, ImageXpress Ultra™, MetaXpress™ soft- Nanopoint, Inc. is a privately-held nano-biotechnology Bethesda, MD 20892 ware for image acquisition, Application Modules for company that is revolutionizing the study and treat- Tel: 301-451-7753 Fax: 301-480-3869 automated image analysis, AcuityXpress™, a power- ment of diseases with its live cell imaging solutions. www.nichd.nih.gov ful cellular informatics package and MetaMorph®, a Nanopoint’s cellTRAY® Imaging System products Our research focuses on enhancing understanding of powerful integration of software and hardware that have broad applications to life science research, drug the biology of development and reproduction, empha- automates image acquisition, processing and analysis discovery, and biopharmaceutical production as well sizing investigations in physics, chemistry, and biology from scientific grade digital CCD cameras. Visit us at as other areas where live cell imaging and analysis of cells; their component parts; and processes that booth #900 to see our complete solutions including is important. govern their function. Join our 250 fellows in an envi- microplate assays. ronment of imagination and scientific inquiry.

197 EXHIBITORS The American Society for Cell Biology 47th Annual Meeting December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org

NATIONAL INSTITUTE OF NATURE PUBLISHING GROUP 218 NIH STEM CELL INFORMATION 125 GENERAL MEDICAL SCIENCES 75 Varick Street, 9th Floor Building 31, Room 3C-27 (NIGMS) 123 New York, NY 10013 Bethesda, MD 20892 45 Center Drive MSC 6200 Room 3AN32 Tel: 212-726-9636 Fax: 212-563-7041 Tel: 301-402-2313 Fax: 301-402-2265 Bethesda, MD 20892 www.nature.com stemcells.nih.gov Tel: 301-496-7301 Fax: 301-402-0224 Nature Publishing Group is committed to publishing The NIH Stem Cell Research exhibit will provide infor- www.nigms.nih.gov high quality, rigorously peer-reviewed research, mation on NIH-supported initiatives for stem cell The National Institute of General Medical Sciences review and reference material in print and online. The research, such as funding opportunities, federal (NIGMS) is one of the National Institutes of Health NPG portfolio combines the continued excellence of guidelines, stem cell training, and cell availability. The (NIH), the principal biomedical research agency of the Nature and its associated research and review jour- NIH Stem Cell web site, as well as opportunities to Federal Government. NIGMS primarily supports basic nals. Visit the NPG stand to pick up copies of Nature, speak with NIH stem cell representatives, will be avail- biomedical research that lays the foundation for Nature Cell Biology and other titles. able at the booth. advances in disease diagnosis, treatment, and pre- vention. NEW ENGLAND BIOLABS, INC. 1131 NIKON INSTRUMENTS INC. 529 240 County Way 1300 Walt Whitman Road NATIONAL INSTITUTE OF HEALTH, Ipswich, MA 01938 Melville, NY 11747 OFFICE OF INTRAMURAL Tel: 978-380-7388 Fax: 978-380-7479 Tel: 631-547-8500 Fax: 631-547-8652 TRAINING AND EDUCATION 129 www.neb.com www.nikonusa.com 2 Center Drive Bldg 2 Room 2W25 MSC 0240 NEB, the first choice for recombinant and native Nikon Instruments Inc., a global leader in the develop- Bethesda, MD 20892 enzymes for genomic research. Products include ment of advanced optical technology, will exhibit: New Tel: 301-496-2427 Fax: 301-402-0483 expression systems (bacterial, mammalian and yeast FN-1 multi-patch system; TE2000E Perfect Focus www.training.nih.gov (K.lactis)), protein modifying enzymes, markers, RNA System; C1si Spectral Imaging Confocal system; The NIH Office of Intramural Training and Education products and transfection reagents. NEB's reagents LiveScan, SFC fast scanning confocal; advanced administers training opportunities in 1250 NIH intra- set standards for quality/value, including competent imaging software solutions; Multi-spectral TIRF. And mural laboratories, which focus on biomedical cells, Taq DNA Polymerase and Phusion DNA Poly- the New innovative Nikon Biostation Visit Nikon at research. Positions are available for postdoctoral fel- merase for fast/robust PCR. http://www.nikonusa.com or call 800-52-NIKON lows; graduate, medical, and dental students; and recent college graduates. The NIH brings biologists, NEWCOMER SUPPLY 715 NORGEN BIOTEK CORPORATION 430 chemists, physicists, engineers and computational/ 2205 Parview Road 3430 Schmon Parkway information scientists together to address health prob- Middleton, WI 53562 Thorold, Ont, L2V 4Y6 Canada lems. Tel: 800-383-7799 Fax: 608-831-0866 Tel: 905-227-8848 Fax: 905-227-1061 www.newcomersupply.com www.norgenbiotek.com NATIONAL INSTITUTE ON DRUG Newcomer Supply is a Histology Laboratory Supplier Norgen Biotek is an innovative, privately-held Cana- ABUSE (NIDA) 131 for 21 years. We provide Stains, Fixatives, Positive dian biotechnology company specializing in sample 6001 Executive Blvd., Suite 5213 Controls, etc. New Product Patent: FrozFix® devel- preparation. Norgen provides life scientists with inno- Bethesda, MD 20892 oped for frozen sections; improves antigenicity & mor- vative DNA, RNA and protein purification, isolation Tel: 301-594-6142 Fax: 301-443-7397 phology. We are also a distributor of Innovex Biosci- and clean-up kits based on its proprietary technology. www.drugabuse.gov ences’ full range of primary antibodies, IHC staining Norgen is actively working to bundle these sample NIDA is a Federal agency charged with supporting kits, special immuno enhancement products (i.e. Fc preparation kits with diagnostic kits. research on the causes, prevention, and treatment of Receptor Blocker & Background Buster) all aspects of drug abuse, including AIDS. Research NUAIRE, INC. 402 results help solve drug abuse and addiction problems. NEXCELOM BIOSCIENCE 1248 2100 Fernbrook Lane Publications and research opportunities will be avail- 360 Merrimack Street Plymouth, MN 55447 able. Lawrence, MA 01843 Tel: 763-553-1270 Fax: 763-553-0459 Tel: 978-327-5340 Fax: 978-327-5341 www.nuaire.com www.nexcelom.com National Research Council of the National Academies—Booth 139 NuAire - recognized universally as the leader in pro- Postdoctoral & Senior Research Awards in US Government Labs Cellometer® - imaging-based automatic cell counting viding laboratory professionals with reliable products Information at www.national-academies.org/rap system to replace manual hemacytometer. Without for the most demanding environments: CO2 Incuba- extra reagent, cells such as PBMC, CD4, Hela, MCF7, tors, Laminar Airflow, Biological Safety Cabinets, and and HEK293 are pipetted into disposable counting a variety of complementary products to serve the NATIONAL RESEARCH COUNCIL chambers for cell counting and trypan blue viability needs of the laboratory community. OF THE NATIONAL ACADEMIES 139 determination. Also cell morphology observation and Best Products – Best Performance – Best Protection Fellowship Programs 500 5th Street NW, Keck 568 heterogeneous population analysis. Washington, DC 20001 NUNC BRAND PRODUCTS 429 Tel: 202-334-2760 Fax: 202-334-2759 NIH OFFICE OF BIOTECHNOLOGY 75 Panorama Creek Drive www.national-academies.org/rap ACTIVITIES 137 Rochester, NY 14625 The National Research Council of the National Acade- 6705 Rockledge Drive, Suite 750 Tel: 585-899-7230 Fax: 585-586-3294 mies offers awards for independent postdoctoral and Bethesda, MD 20892 www.nuncbrand.com senior scientific research in all disciplines of the life Tel: 301-496-9838 Fax: 301-496-9839 Cell/tissue culture consumable products: flasks, sciences to be conducted at participating U.S. govern- www4.od.nih.gov/oba dishes, plates, etc. ment laboratories. Awards include generous stipend, Monitors scientific progress in human genetics relocation, professional travel and health insurance. research in order to anticipate future developments, OBJECTIVE IMAGING LTD 636 Deadline dates and application instructions are at including ethical, legal, and social concerns, in basic 25707 Minnetonka Drive www.national-academies.org/rap. and clinical research involving Recombinant DNA, Kansasville, WI 53139 Genetic Technologies, and Xenotransplantation. Also Tel: 262-514-2313 Fax: 262-514-2388 NATIONAL SCIENCE FOUNDATION 121 manages the operation of, and provides analytical www.objectiveimaging.com 4201 Wilson Boulevard, Suite 655 support to, the NIH Recombinant DNA Advisory Com- Arlington, VA 22230 Objective Imaging offers hardware and software solu- mittee, the DHHS Secretary's Advisory Committee on tions for automated microscopy and imaging. Our Tel: 703-292-4538 Fax: 703-292-9061 Genetics, Health, and Society, and the DHHS Secre- www.nsf.gov Oasis high performance controllers support XY tary's Advisory Committee on Xenotransplantation. stages, Z focus drives, filter wheels, shutters and other The NSF is an independent agency of the Federal automated components. Our Surveyor with Turboscan government that offers research grants, fellowships, solution quickly creates large-scale mosaic images and other modes of support for scientific and engi- using standard microscopes and accessories. neering research and education. Information will be disseminated about NSF programs of potential inter- est to cell biologists.

198 The American Society for Cell Biology 47th Annual Meeting EXHIBITORS December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org

OKOLAB: LIVE CELL MICROSCOPY 1010 OPEN BIOSYSTEMS 747 PEPROTECH, INC. 1028 Via G. Di Prisco, 152 6705 Odyssey Drive 5 Crescent Avenue P.O. Box 275 Ottaviano (NA), AB 80040 Italy Huntsville, AL 35806 Rocky Hill, NJ 08553 Tel: 011-39-81-806-2624 Fax: 011-39-81-876-4410 Tel: 256-704-4848 Fax: 256-704-4849 Tel: 609-497-0253 Fax: 609-497-0321 www.microscopeincubator.com www.openbiosystems.com www.peprotech.com Okolab manufactures innovative Microscope Incuba- Open Biosystems is the world’s leader in supplying PeproTech manufactures an extensive line of Recom- tion Chambers, develops intelligent Time-lapse soft- genomic content including full length, fully sequenced binant Human, Murine and Rat Cytokines as well as a ware for computer-controlled experiments and inte- cDNA clones, shRNAmir clones and custom antibody complementary line of Monoclonal Antibodies, Affinity grates light microscopy systems taylored on your services. The combination of our unique Trans-lentivi- Purified Polyclonal Antibodies, Affinity Purified Biotin- needs, thus providing complete and reliable solutions ral delivery system and whole genome RNAi & cDNA ylated Polyclonal Antibodies and ELISA Develop- for Live Cell Microscopy. Two complete time-lapse content facilitates characterization of gene function in ment Kits. fluorescence microscopy workstations, a light and a cancer, neuroscience and development. full version, will be exhibited. PEPTIDES INTERNATIONAL 442 ORIGENE YOUR GENE COMPANY 1147 11621 Electron Drive OLINK BIOSCIENCE 1343 6 Taft Court Louisville, KY 40299 Dag Hammarskjolds Vag 54A Rockville, MD 20850 Tel: 502-266-8787 Fax: 502-267-1329 Uppsala, SE75183 Sweden Tel: 888-267-4436 Fax: 301-340-8606 www.pepnet.com Tel: 011-46-1850-0001 Fax: 011-46-1850-9300 www.origene.com Peptides International specializes in high purity bio- www.olink.com OriGene, a gene-centered company, is the largest logically active peptides and related products, enzyme Olink Bioscience focuses on innovative methods for provider for ready-cloned human full-length cDNA. inhibitors and substrates, peptide antisera, amino acid detecting endogenous proteins, protein complexes With its renowned TrueClone – a searchable collection derivatives, resins, and peptide synthesis tools. Cus- and nucleic acids in basic research and for high-con- of 33,000 expression-ready human cDNA clones, Ori- tom Synthesis Services include high-purity peptides tent screening, for delivering accurate information on Gene also provides effective shRNA for all mouse and and substrates, combinatorial chemistry (soluble and disease mechanisms and drug response. Our mission human genes. The novel GFC-Arrays, genome-wide resin-bound libraries), amino acid derivatives, and res- is to contribute to a better understanding of the inter- high-throughput functional screen tools, are revolu- ins for SPS. actome. tionizing the way for gene discovery. PERKIN ELMER 1141 OLYMPUS AMERICA INC. 1119 PAA LABORATORIES, INC., USA 649 710 Bridgeport Avenue 3500 Corporate Parkway PO Box 610 777 Church Street Shelton, CT 06484 Center Valley, PA 18034 New Bedford, MA 02745 Tel: 203-402-6973 Fax: 203-944-4950 Tel: 484-896-5852 Fax: 484-896-7153 Tel: 508-984-5881 Fax: 508-984-5861 www.perkinelmer.com www.olympusamerica.com www.paa.com PerkinElmer serves a number of growing industries Olympus will be proudly displaying the FV1000 laser PAA specializes in the manufacture and worldwide and markets including the environmental, pharmaceu- scanning confocal with dual scanner and new multi- distribution of cell culture products for research, devel- tical, chemical, petrochemical, semiconductor, aca- photon excitation capabilities. Our market leading IX opment, diagnostic and biopharmaceutical produc- demic research, biotechnology, and clinical screening inverted microscopes will also be featured alongside tion. We manufacture animal & human sera, synthetic segments. Our total application-driven laboratory our excellent long working distance water objectives, media, protein-free media, biochemical supplements solutions help our customers speed drug discovery, spinning disk confocal and BX upright microscopes. and reagents, all of which are used as cell nutrients enhance research productivity, meet strict regulatory in cell culture technology. PAA has manufacturing requirements, improve time-to-market, and increase OMEGA OPTICAL, INC. 1004 operations in Europe, North America and Australia, manufacturing efficiencies. Delta Campus, Omega Drive selling products in over 40 countries world-wide Brattleboro, VT 05301 through direct sales and distributors. PHOTOMETRICS 616 Tel: 802-254-2690 Fax: 802-254-3937 3440 East Britannia Drive, Suite 100 www.omegafilters.com PACIFIC NORTHWEST NATIONAL Tucson, AZ 85706 Omega Optical is launching QuantaMAX™, a new LABORATORY 432 Tel: 520-889-9933 Fax: 520-573-1944 product line of durable, environmentally stable, high P.O. Box 999 K1-55 www.photomet.com signal-to-noise filter sets. QuantaMAX™’s high Richland, WA 99352 Photometrics is the world's premier designer and man- throughput filter sets utilize state-of-the-art EP coat- Tel: 509-375-6967 Fax: 509-375-2491 ufacturer of high-performance EMCCD and CCD cam- ings (Energetic Process) which are spectrally stable, www.pnl.gov eras for the life sciences. Our popular Cascade (the mechanically robust, and insensitive to moisture. We Pacific Northwest National Laboratory, operated by first EMCCD camera series specifically engineered also design and manufacture an extensive selection Battelle for the U.S. Department of Energy, is a leader for microscopy) and new FireWire-enabled CoolSNAP of dye-specific filter sets for single and multi-label in systems biology. We combine advanced analytical cameras are optimized to meet a broad range of strin- microscopy applications, including M-FISH, Quantum methods, high-resolution imaging, and computer mod- gent sensitivity, speed, and resolution requirements. Dots, Fluorescent Proteins, Multiphoton, Confocal, eling to observe and understand cellular networks. We offer knowledgeable application support, a global FRET, FLIM, FRAP, TIRF, Pinkel, and Ratio Imaging. PNNL houses a user facility with unique instrumenta- service network, extensive R&D capabilities, and tion and resources for molecular science and sys- OEM-friendly programs. OMNI INTERNATIONAL: THE tems biology. HOMOGENIZER COMPANY 1314 PHOTONIC INSTRUMENTS, INC. 822 1000 Williams Drive, Suite 1024 PARK SYSTEMS, INC. 132 2435 Dean Street, Suite A Marietta, GA 30066 3040 Olcott Street St. Charles, IL 60175 Tel: 770-421-0058 Fax: 770-421-0206 Santa Clara, CA 95054 Tel: 630-587-1890 Fax: 630-587-1892 www.omni-inc.com Tel: 408-986-1110 Fax: 408-986-1199 www.photonic-instruments.com Omni International, Inc. is the leading manufacturer www.parkafm.com Photonic Instruments will be exhibiting the Mosaic of laboratory and batch process scale products to Park Systems XE-Bio system images biological sam- Digital Diaphragm System and MicroPoint Laser Sys- homogenize samples from.03ml to 500L in open or ples with two different SPM techniques at a same tem. Visit our booth to see real time digital FRAP, aerosol sealed containers. Eliminate sample cross- place. A new ion conductance microscope module FRET and Photoactivation solutions for your optical contamination with patented Omni Tip™ plastic gener- has been developed on a conventional AFM platform, microscope. Laser ablation and laser induced injury ator probes and PCR kits. The Omni Prep Multi-Sam- uses a glass micro pipette as a sensitive probe instead systems will also be showcased. ple Homogenizer lets you process six samples with of silicon based stylus to image live cells. the touch of a button! Visit us at www.omni-inc.com.

199 EXHIBITORS The American Society for Cell Biology 47th Annual Meeting December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org

PHOTON TECHNOLOGY POINT SOURCE 1418 PROMEGA CORPORATION 1022 INTERNATIONAL, INC. 144 Mitchell Point, Ensign Way 2800 Woods Hollow Road P.O. Box 272, 300 Birmingham Road Hamble, SO31 4RF UK Madison, WI 53711 Birmingham, NJ 08011 Tel: 1-800-898-6504 Fax: 011-44-2380-744501 Tel: 608-277-2497 Fax: 608-277-2601 Tel: 609-894-4420 Fax: 609-894-1579 www.point-source.com www.promega.com www.pti-nj.com Point Source designs and manufactures high perfor- Promega Corporation is a worldwide leader in Photon Technology International designs, manufac- mance fiber optic laser delivery systems and lasers applying biochemistry and molecular biology to the tures and markets proprietary electro-optical instru- for commercial applications in biotechnology and development of innovative, high-value products for ments for use in leading laboratories around the world semiconductor manufacturing. the life sciences. Product focus includes genomics, for medical research, health care, industrial process, We offer a personalised service and produce fully cellular analysis and functional proteomics, including quality control, environmental science and other appli- customised products to meet exact fit, form and func- products for protein purification, expression, imaging, cations. On display will be the EasyRatioPro imaging tional requirements; from prototypes to volume manu- and protein interaction analysis. system and our RatioMaster (RM-5) photometry facture, servicing and next generation design. system. PROMOCELL GMBH 907 POLYPLUS-TRANSFECTION 814 Sickingenstrasse 63-65 PHOTRON USA, INC 530 Bioparc Boulevard Sebastien Brant D-69126 Heidelberg, Germany 9520 Padgett Street, Suite 110 BP90018 Illkirch, 67401 France Tel: 011-866-251-2860 Fax: 011-866-827-9219 San Diego, CA 92126 Tel: 011-33-390-406180 Fax: 011-33-390-406181 www.promocell.com Tel: 858-684-3555 Fax: 858-684-3558 www.polyplus-transfection.com PromoCell, The Experts for Normal Human Cell. At www.photron.com Polyplus-transfection develops and manufactures PromoCell we are committed to provide researchers Photron will be showing the FocusScope SV-200i; a synthetic reagents for the delivery of biomolecules worldwide with a broad range of normal human cells unique marriage of broad spectral response (280nm such as DNA, siRNA and proteins in eukaryotic cells and optimized cell culture media. Furthermore we sup- to 720nm - peak sensitivity at 530 nm) Gen III image or in vivo models. The range of Polyplus reagents will ply well proven products for cell biology research such intensifier and sensitive high speed camera. be presented including jetPEI™ proprietary products as user-friendly cell transfection kits or fluorescence The SV-200i is perfect for Biofluorescence imaging, and in vivo DNA delivery technology. Scientists and labeling reagents. You can count on our high quality Micro Particle Imaging Velocimetry (PIV) and Fluores- Business Representatives will be available. products backed by experienced technical support cence Recovery After Photo-bleaching (FRAP). and friendly customer service. PRECISION PLASTICS, INC. 1006 PI (PHYSIK INSTRUMENTE) L.P. 405 6405A Ammendale Road PROQUEST 355 16 Albert Street Beltsville, MD 20705 789 East Eisenhower Parkway Auburn, MA 01501 Tel: 301-937-1317 Fax: 301-937-4184 Ann Arbor, MI 48108 Tel: 508-832-3456 Fax: 508-832-0506 www.precisionplastics.com Tel: 734-761-4700 Fax: 734-997-4224 www.physikinstrumente.com/en/solutions/microsco- Precision Plastics manufactures easily customizable www.proquest.com py.php?ASCB07 unique black microscope enclosures that control light, ProQuest provides seamless access to and navigation Leading, ISO 9001 certified manufacturer of Nanofo- temperature, humidity, CO2 and O2. Large access of more than 125 billion digital pages of the world’s cus / Nanopositioning Devices for Scanning Micros- doors make for easy set up. Our tight seal closed loop scholarship, delivering it to the desktop and into the copy and 3D Microscopy. Products: PIFOC® Piezo-Z system minimizes gas usage. Working with scientist workflow of serious researchers in multiple fields, from Motors; XYZ Scanning Stages; Fast Steering Mirrors; at NIH we have created an enclosure that stays on arts and literature to science, technology and medi- Piezo-Scanner Tubes; Piezo Drivers; Digital Piezo the microscope. cine. For more information, please visit www.proques- Controllers (Improved Settling, Speed, Linearity); t.com and www.csa.com. Hexapod 6-Axis Alignment Stages; Capacitive Dis- PRIMMBIOTECH, INC. 948 placement Sensors (Subnanometer Precision). 8 Rutledge Street PROTEA BIOSCIENCES, INC. 642 Global Support. 30+ Years Experience. West Roxbury, MA 02132 955 Hartman Run Road Suite 210 Tel: 800-893-4388 Fax: 617-325-2703 Morgantown, WV 26507 PLATYPUS TECHNOLOGIES 714 www.primmbiotech.com Tel: 304-292-2226 Fax: 304-292-7101 5520 Nobel Drive, Suite 100 PrimmBiotech specializes in research services that www.proteabio.com Madison, WI 53711 include: custom polyclonal & monoclonal antibody Protea develops new products and services that gen- Tel: 608-237-1270 Fax: 608-237-1271 development, synthesis of peptides, bioactive pep- erate improvements in the quality and reproducibility www.platypustech.com tides, phosphopeptide synthesis, recombinant protein of protein mass spectrometry data obtained from bio- Platypus Technologies announces the launch of the development, MS fingerprinting, MALDI-TOF Mass logical samples. Oris Cell Migration Assay. This is a two-dimensional spec analysis, N-terminal sequencing, and animal Our products are used to prepare protein samples for migration assay that is highly reproducible, comes in studies downstream analysis by mass spectrometry. We seek a 96-well format, is compatible for high-throughput to improve the quality and reproducibility of data analysis, allows for morphological monitoring of cells, PRIOR SCIENTIFIC, INC. 1214 obtained by our customers in their laboratories. All and allows either kinetic or endpoint studies. Visit 80 Reservoir Park Drive our products are tested for assurance that they will booth 714 to learn more. Rockland, MA 02370 not interfere with mass spectrometric analytical tech- Tel: 781-878-8442 Fax: 781-878-8736 niques. PNAS (PROCEEDINGS OF THE www.prior.com NATIONAL ACADEMY OF Prior Scientific is a manufacturer of precision motor- PROTEINONE 1448 SCIENCES) 225 ized stages, Nanopositioning Piezo Z stages, motor- 6931 Arlington Road Suite T100 500 5th Street NW NAS 340 ized focus control, high-speed motorized filter wheels, Bethesda, MD 20814 Washington, DC 20001 electronic shutters, microscopes, microscopy acces- Tel: 301-657-1405 Fax: 301-657-1408 Tel: 202-334-2696 Fax: 202-334-1346 sories and custom optical systems. Current products www.proteinone.com www.pnas.org include the Prior PCI Stepper Motor controller, the ProteinOne is a development stage biotechnology The Proceedings of the National Academy of Sci- highest precision microscope stages available, company doing business in Bethesda Maryland, USA. ences, U.S.A. (PNAS), one of the most highly cited remote focus systems, stereo microscopes and video The primary aim of the company is to deliver purified, multidisciplinary scientific journals, appears in print zoom microscope systems. biologically active proteins to research labs, medical weekly and online daily. PNAS publishes high impact institutions and pharmaceutical companies via a Uni- research papers, commentaries, colloquium articles, PRO SCIENTIFIC INC. 513 versal Protein Array (UPA) under development by the National Academy member profiles, and inaugural 99 Willenbrock Road company to help companies with their drug discov- year articles. Free issues, posters, and giveaways will Oxford, CT 06478 ery program. be available. Tel: 203-267-4600 Fax: 203-267-4606 www.proscientific.com PRO Scientific manufacturers homogenizers to pro- cess handheld as well as benchtop homogenizers for a variety of applications. PRO’s Lab Plus Series line features vortex mixers, nutating mixers, orbital shak- ers and rockers. New for PRO is our line of PRO- Vantage microcentrifuges. PRO is also a leading dis- tributor of Hettich centrifuges.

200 The American Society for Cell Biology 47th Annual Meeting EXHIBITORS December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org

PROTEINTECH GROUP, INC. 1151 RAINDANCE TECHNOLOGIES, INC 1048 SAKURA FINETEK USA 342 2201 West Campbell Park Drive 530 Whitfield Street 1750 West 214th Street Chicago, IL 60612 Guilford, CT 06437 Torrance, CA 90501 Tel: 312-455-8498 Fax: 312-455-8408 Tel: 203-458-2947 Fax: 203-458-2947 Tel: 800-725-8723 Fax: 310-972-7888 www.ptglab.com www.raindancetechnologies.com www.sakuraus.com Proteintech Group's mission is to fulfill the Human The RainDance Technologies Professional Labora- Sakura is the manufacturer of Tissue-Tek® and Cyto- EST fusion protein Project and Proteomic Antibody tory System (PLS) utilizes droplet-based microfluidics Tek® instrumentation and products. The company Project. To meet research needs and individual scien- technology to analyze and sort biochemical and markets many instruments and consumables for his- tists, the company offers affordable polyclonal/mono- molecular reactions on the order of 10,000 per sec- tology, cytology and research labs worldwide. The clonal antibodies and custom services including anti- ond. Our product line features a diverse menu of assay most recent product introductions are the Tissue-Tek® body, peptide and protein production with complete kits for cell-based assays, enzyme screening, and Xpress® Rapid Tissue Processor and AutoTEC® technical support. nucleic acid analysis. Automated Embedding System, enabling continuous processing and embedding up to 120 specimens/hour. PROTEOPURE, INC. 1341 RAININ INSTRUMENT, LLC 1303 These new technologies allow for same day turn- 900 William Pitt Way 7500 Edgewater Drive around for results. Pittsburgh, PA 15238 Oakland, CA 94621 Tel: 412-826-3140 Fax: 412-826-3142 Tel: 510-564-1600 Fax: 510-564-1795 SANYO COMMERCIAL SOLUTIONS 104 www.proteopure.com www.rainin.com 1062 Thorndale Avenue Proteopure provides sample preparation kits for pro- On display at Rainin Instrument, LLC will be Pipettes: Bensenville, IL 60106 teomic researchers. The kits feature a protein specific Ergonomic Pipet-Lite®, EDP®3 single, multi-channel, Tel: 630-694-8265 Fax: 630-238-0074 “hook” that enables much better elimination of all con- manual and electronic pipettes with LTS® Lite www.sanyobiomedical.com taminants, including SDS detergent molecules bound Touch™ Tip Ejection, reducing tip ejection force by SANYO Biomedical, a division of SANYO Electric Co. to proteins, and avoids protein losses typical of precip- 85%. Rainin Classic traditional pipette with 25% less of Osaka, Japan is a leading, vertically-integrated, itation methods, thereby achieving better, more reli- plunger force than competitors. Hand-friendly Pos- manufacturer and worldwide distributor of Ultra Low able results. D positive-displacement pipettes. Tips: SpaceSaver Temperature Freezers, Incubators, Laboratory environmental tip-rack refills, other packaging solu- Refrigeration, and other Environmentally Controlled QIMAGING 517 tions. Bioclean, aerosol-resistant. Pipette Service: Equipment. SANYO utilizes unique design and com- 19535 56th Avenue Suite 101 Calibration PM™, ISO 17025 accreditation, and ponent technologies to deliver reliable and consistent Surrey, BC, V3S 6K3 Canada OnSite PM™. test and storage environments. Tel: 604-708-5061 Fax: 604-539-1825 www.qimaging.com RESEARCH ORGANICS, INC. 309 SARSTEDT, INC. 1037 QImaging specializes in providing CCD and EMCCD 4353 East 49th Street 1025 St. James Church Road digital FireWire IEEE 1394 cameras for life science Cleveland, OH 44125 Newton, NC 28658 applications. New engineering innovations ensure that Tel: 216-883-8025 Fax: 216-883-1576 Tel: 800-257-5101 Fax: 828-465-0718 our Retiga, Rolera, QICAM, and MicroPublisher cam- www.resorg.com www.sarstedt.com era lines will continue to provide easy-to-use quantita- Research Organics is a primary manufacturer of high The Sarstedt Group develops, manufactures, and tive image analysis and high-resolution publication purity biochemicals, for use in molecular biology, diag- markets laboratory consumables and equipment. The imaging. QImaging has formed numerous alliances nostic chemicals, cloning applications and cell culture. company's range of lab products is the result of in- with third-party software companies and system integ- Our broad product line includes biological buffers, house design and stringent quality control procedures. rators to deliver comprehensive imaging solutions and molecular biochemicals, enzyme substrates, fluores- Included are cell and tissue culture labware; consum- application-specific software. cent compounds, ACS Reagents, amino acid deriva- ables for PCR, molecular biology, and microbiology; tives. as well as benchtop instruments. QORPAK 1249 Corporate One West ROCHE APPLIED SCIENCE 705 SCIENCELL RESEARCH 1195 Washington Pike 9115 Hague Road Bldg B LABORATORIES 108 Bridgeville, PA 15017 Indianapolis, IN 46250 6076 Corte Del Cedro Tel: 412-257-3100 Fax: 412-257-3001 Tel: 317-521-2464 Fax: 317-521-4396 Carlsbad, CA 92011 www.qorpak.com www.roche-applied-science.com Tel: 760-602-8549 Fax: 760-602-8575 Qorpak features quality labware including petri dishes, Roche Applied Science is one of the world's leading www.sciencellonline.com cell scrapers & spreaders, multi-well plates, liquid producers of reagents and systems for life science ScienCell Research Laboratories is a San Diego media, swabs, media bottles, roller & tissue culture research. Our innovative products and technologies based biotechnology company. We develop cell and bottles, exam gloves, mixers, shakers & hot plates, include FuGENE® HD Transfection Reagent, cOm- cell-related products for research use. We currently Whatman® syringe & syringeless filters, and Pyrex® plete Protease Inhibitor Cocktail tablets, the LightCy- provide over 100 cell types of high quality normal beakers & flasks. See our wide selection of laboratory cler® technology for real-time quantitative PCR and human and animal cells, specialty media, medium containers & closures. the MagNAPure systems for automated nucleic acid supplements, cell culture reagents, cell-derived purification. cDNA, RNA and proteins for research community QUANSYS BIOSCIENCES 343 worldwide. 365 North 600 West ROCKLAND IMMUNOCHEMICALS, Logan, UT 84321 INC. 1148 SCIENTIFIC INDUSTRIES, INC. 924 Tel: 435-750-0959 Fax: 435-750-6869 P.O. Box 326 70 Orville Drive www.quansysbio.com Gilbertsville, PA 19525 Bohemia, NY 11716 Quansys Biosciences specializes in the development Tel: 800-656-7625 Fax: 610-367-7825 Tel: 631-567-4700 Fax: 631-567-5896 of highly sensitive and robust multiplexed ELISAs. Our www.rockland-inc.com www.scientificindustries.com Quansys Array is capable of simultaneously quantify- Antibodies for Signaling Research. Antibodies include Scientific Industries, best known for its flagship prod- ing multiple biomarkers to generate a biochemical pro- Akt pathway, Cell Cycle & Checkpoint control, Cytok- uct, the Vortex-Genie, is a world leader in the design file. The Quansys Array provides researchers an easy ines, Collagens, DNA Damage, NfkB pathway and and manufacturing of vortex mixers, shakers, and stir- to use multiplex ELISA platform that helps save pre- Ubiquitin. Secondary antibodies are conjugated to rers. cious sample, time, and money. Near IR Dyes, Alkaline Phosphatase, Cy dyes, Biotin, FITC, Magnetic Particles, Peroxidase, Phycoerythrin, R&D SYSTEMS, INC. 610 Rhodamine and Texas Red. Rockland has the ability 614 McKinley Place NE to custom produce antibodies as well as develop Minneapolis, MN 55413 assays for your research needs Tel: 612-379-2956 Fax: 612-379-6580 www.rndsystems.com R&D Systems serves the basic research, clinical research, and diagnostic markets with products for cell biological research. We provide purified proteins; antibodies; kits and reagents for ELISAs, multiplex assays, and assay services.

201 EXHIBITORS The American Society for Cell Biology 47th Annual Meeting December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org

SEAHORSE BIOSCIENCE, INC. 112 SOLAMERE TECHNOLOGY GROUP, ST. JUDE CHILDREN'S RESEARCH 16 Esquire Road INC. 418 HOSPITAL 143 North Billerica, MA 01862 1427 Perry Avenue 332 North Lauderdale Street MS 276 Tel: 978-671-1697 Fax: 978-671-1611 Salt Lake City, UT 84103 Memphis, TN 38105 www.seahorsebio.com Tel: 801-322-2645 Fax: 801-322-2645 Tel: 901-495-3424 Fax: 901-495-5376 Seahorse Bioscience is the leading provider of tools www.solameretech.com www.stjude.org/education for real-time measurement of cellular bioenergetics. Solamere Technology Group offers Advanced , Cut- St Jude Children's Research Hospital is a non-profit The company designs, manufactures and markets the ting Edge Imaging Systems and knowledgeable Appli- biomedical research institution in Memphis, TN, where XF24 Extracellular Flux Analyzer and XF assay kits cation Assistance for Cell Biology; including but not 190 basic science and clinical researchers investigate for use in academic and government institutions, and limited to CSU-10 and CSU-22 confocal Systems from the molecular basis of both normal cellular and dis- pharmaceutical and biotech companies. Seahorse Yokogawa; AOTF controlled Multi-Laser Illumination eased processes. Visit our booth to discuss and apply Bioscience's Extracellular flux (XF) technology is Systems; advanced cost effective Software Solutions; for Postdoctoral Fellowship positions for PhD, MD, changing cancer, obesity and diabetes drug discovery Low Light Cameras. "Scientists helping Scientists" PharmD, and DVM students. programs the world over. SOLENT SCIENTIFIC (FORMERLY STANFORD PHOTONICS INC. 420 SELECTSCIENCE 348 BUCK SCIENTIFIC) 629 1032 Elwell Court, Suite 104 Church Farm Business Park 58 Fort Point Street Palo Alto, CA 94303 Corston Bath, BA2 9AP UK East Norwalk, CT 06855 Tel: 650-969-5991 Fax: 650-969-5993 Tel: 011-44-1225-874666 Fax: 011-44-1225- Tel: 203-853-9444 Fax: 203-853-0569 www.stanfordphotonics.com 874123 www.bucksci.com Stanford Photonics, Inc. designs and manufactures www.selectscience.net On display will be the Solent Scientific microscope CCD and ICCD cameras for photon-limited life science SelectScience is a free online resource for laboratory indubation chambers. These chambers are custom imaging. Mega-pixel resolution and speeds of 30 to scientists, featuring the latest application and industry made to fit each microscope and guaranteed to fit and 1000 fps are supported by proprietary image acquisi- news, conferences, jobs and extensive product direc- hold 37 degrees Celsius. Incubation chambera are tion and RAID-based streaming software. SPI also tory. Visitors can share information with peers and available for invferted and upright microscopes manu- provides systems for TIRF, single molecule and single make an impact on the community by rating the prod- factured by Olympus, Zeiss, Leica and Nikon. photon/ultra low-light luciferase and biolumines- ucts used in their lab... So whether you want to read cence imaging. the latest developments in your area, source a new SPECTRAL APPLIED RESEARCH, career or find a solution for your laboratory, visit INC. 110 STOVALL LIFE SCIENCE, INC. 308 www.selectscience.net and see why we are “the sci- 10 North Rivermede Road 206-G. South Westgate Drive entist’s choice”! Concord, ON L4K 2H2 Canada Greensboro, NC 27407 Tel: 905-326-5040 Fax: 905-326-5041 Tel: 800-852-0102 Fax: 336-852-3507 SEMROCK, INC. 1215 www.spectralappliedresearch.com www.slscience.com 3625 Buffalo Road Suite 6 Spectral Applied Research develops new optical Stovall Life Science designs, manufactures and mar- Rochester, NY 14624 instruments, as well as performance enhancing optics kets laboratory instruments for the life science Tel: 585-594-7000 Fax: 585-594-7095 for existing systems. Spectral has current products research market. Products include: The Belly Dancer, www.semrock.com serving confocal microscopy, TIRF, flow cytometry, The Belly Button, light weight and quick heating water Semrock manufactures high-performance hard- and other cell biology research fields. Spectral offers baths, a low profile rocker and a low profile bottle coated ("no burn-out") optical filters that set the stan- retrofits of existing Yokogawa spinning disk systems roller, hybridization oven and an automated processor dard for Biotech & Analytical Instrumentation; with per- that will improve the light throughput and confocality. of Western blots. It is Stovall’s mission to serve the formance-enhancing filters for fluorescence micros- life science research community by creating novel, copy, laser-based confocal and multi-photon instru- SP INDUSTRIES 643 durable and needed equipment to make the investiga- mentation, & Raman spectroscopy. 707 Executive Blvd, Suite D tor’s work simpler, more efficient and effective. Valley Cottage, NY 10989 SIGMA 1232 Tel: 845-267-2211 Fax: 845-267-2212 STRATEGIC DIAGNOSTICS, INC. 823 3050 Spruce Street www.SPindustries.com 111 Pencader Drive St. Louis, MO 63130 SP Industries is a leading manufacturer of NMR and Newark, DE 19702 Tel: 314-286-7727 Fax: 314-286-7817 EPR sample tubes, specialty laboratory glassware, Tel: 800-481-9737 Fax: 302-456-6782 www.sigmaaldrich.com environmental control chambers, precision tempera- www.sdix.com Sigma-Aldrich has been a leading Life Science and ture control systems, glassware washers and dryers, SDI offers a novel technology that enables character- High Technology company since 1945. Through vacuum ovens, evaporators, and laboratory-to-pro- ization of signaling proteins. The Genomic Antibody SIGMA® Life Science we have developed tools duction scale lyophilizers. SP Industries sells its prod- TechnologyTM proprietary platform generates highly enabling researchers to accelerate discovery across ucts under the well-known brands of Wilmad-Lab- specific antibodies requiring only the coding sequence the entire drug development research workflow includ- Glass, Hotpack, FTS, Genevac, VirTis, and Hull. of the target protein. Immunogen is synthesized, ing RNAi and sample prep platforms. For Cell Biology, expressed, and presented in vivo (host animal). The we offer over 5,000 antibodies, receptors, assay kits, SPRINGER 222 platforms is used to generate SDI's SEQer antibodies small molecules and new products every month. See 233 Spring Street that are focused on cancer research. it all today at booth #1232 or visit sigma.com/lifes- New York, NY 10013 cience. Tel: 212-460-1500 Fax: 201-348-4505 SUPERARRAY BIOSCIENCE 455 www.springeronline.com 7320 Executive Way, Suite 101 SIGMA-ALDRICH 1236 Springer publishes high-quality books, jouornals and Frederick, MD 21704 3050 Spruce Street major reference works in the are of Cell Biology. Tel: 301-682-9200 Fax: 301-682-7300 St. Louis, MO 63103 Please stop by the Springer booth to pick up free www.superarray.net Tel: 314-286-7727 Fax: 314-286-7817 sample issues of our journals. SuperArray Bioscience provides products and ser- sigma-aldrich.com vices for pathway-focused gene expression profiling Sigma-Aldrich provides a broad range of cell culture STEMCELL TECHNOLOGIES, INC. 1454 including real-time PCR Arrays, master mixes, and products that can be applied to all fields within cell 400-500 West 7th Avenue assays as well as DNA microarrays and plasmid- biology. With our combined capabilities, Sigma-Ald- Vancouver V5Z 1B3 Canada based RNA Interference. rich and SAFC Biosciences (formerly JRH Biosci- Tel: 800-667-0322 Fax: 800-567-2899 ences) fully supports customers' needs for cell culture. www.stemcell.com Stop by booth 1216 to learn how we can support StemCell Technologies offers a complete spectrum of your needs from bench research to the fast growing products and services for cell biologists. Cell separa- pharmaceutical production market. tion is available for the isolation of virtually any cell type. Cell culture media and reagents are formulated for hematopoietic, mesenchymal, neural, endothelial, epithelial, and embryonic stem cells. Primary cells, antibodies and sera are also available.

202 The American Society for Cell Biology 47th Annual Meeting EXHIBITORS December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org

SUTTER INSTRUMENT COMPANY 805 THE AMERICAN ASSOCIATION OF THE SCIENTIST 408 One Digital Dive IMMUNOLOGISTS 1033 400 Market Street, Suite 1250 Novato, CA 94949 9650 Rockville Pike Philadelphia, PA 19106 Tel: 415-883-0128 Fax: 415-883-0572 Bethesda, MD 20814-3994 Tel: 215-351-1660 Fax: 215-351-1146 www.sutter.com Tel: 301-634-7178 Fax: 301-634-7887 www.the-scientist.com Sutter Instrument has been manufacturing precision www.aai.org The Scientist gives you a detailed look at what's hap- instrumentation for over 30 years. We will have micro- Founded in 1913, the mission of The American Asso- pening inside and outside your field. In print, The Sci- pipette fabrication, imaging hardware, micromanipula- ciation of Immunologists (AAI) is to advance the entist offers a monthly view of the latest trends in tion and microinjection instrumentation on display. We knowledge of immunology and related disciplines, fos- research, technology, business and careers. On the will be featuring the P-97 micropipette puller, stepper- ter interchange of ideas and information among scien- web at www.TheScientist.com, access over 20 years motor controlled SmartShutter, the DG-4 wavelength tists, and promote an understanding of the field of of archives while taking advantage of cutting edge switcher, MPC-200 multi-manipulator controller and immunology. The AAI owns and publishes the largest webtools. motorized manipulators, and XenoWorksÔ microin- and most prestigious journal in the field – The Journal jection system. of Immunology (The JI). THERMO SCIENTIFIC 419 2650 Crescent Drive SVISION LLC 1342 THE COMPANY OF BIOLOGISTS Lafayette, CO 80026 3633 136th Place SE Suite 300 LTD. 229 Tel: 800-235-9880 Fax: 303-604-9680 Bellevue, WA 98006 140 Cowley Road www.thermo.com Tel: 425-773-1548 Fax: 425-643-0498 Bidder Building Thermo Scientific represents Thermo Fisher Scientif- www.svcell.com Cambridge, CB4 0DL UK ic’s broad range of high-end analytical instruments, SVision introduces SVCell™, image recognition soft- Tel: 011-44-1223-426164 Fax: 011-44-1223- chemistry and consumable supplies, laboratory equip- ware that you can teach to segment, measure, clas- 423353 ment, software and services that enable integrated sify, model, and analyze phenotypes and events in www.biologists.com laboratory workflow solutions. your unique microscopy imaging experiment. Teach- The Company of Biologists is the not-for-profit pub- ing requires no image processing knowledge, and is lisher of Journal of Cell Science and Development. THOMSON RESEARCHSOFT 325 updatable for your changing protocol. The taught rec- Journal of Cell Science is one of the leading journals 2141 Palomar Airport Road Suite 350 ipe can be executed in your high throughput assay. in cell biology and is essential reading for cell biolo- Carlsbad, CA 92011 gists in all fields, molecular biologists, geneticists Tel: 760-438-5526 x300 Fax: 760-438-5573 SYSTEM BIOSCIENCES (SBI) 1406 and neurologists. www.thomson.com 1616 North Shoreline Blvd Millions of users depend on EndNote®, ProCite®, Ref- Mountain View, CA 94043 THE JOURNAL OF NEUROSCIENCE 245 erence Manager® and EndNote Web™ to collect and Tel: 650-968-2200 Fax: 650-968-2277 1121 14th Street NW, Suite 1010 organize their references and create bibliographies www.systembio.com Washington, DC 20005 instantly. ResearchSoft offers more publishing tools System Biosciences (SBI) develops and commercial- Tel: 202-962-4000 Fax: 202-962-4945 including RefViz™ -to search for and explore refer- izes kits and reagents for RNAi and microRNA www.jneurosci.org ences visually, and sciPROOF™-to streamline scien- research. SBI has genome-wide shRNA libraries The Journal of Neuroscience, the premier journal in tific proofreading. enabling permanent knockdown of human or mouse the field, is the official journal of the Society for Neuro- genes. SBI commercializes microRNA expression science. Published weekly, The Journal of Neurosci- THORLABS 310 profiling, amplification and discovery/cloning systems. ence features 12,000 pages and covers topics from 435 Route 206 SBI also develops lentiviral-based reagents for stem molecular and cellular neurobiology to behavioral and Newton, NJ 07826 cell research. systems neuroscience. Tel: 973-300-4391 Fax: 973-300-3642 www.thorlabs.com TAKARA BIO USA 448 THE OPEN MICROSCOPY Thorlabs designs, develops, and manufactures build- 510 Charmany Drive, Suite 273 ENVIRONMENT 1250 ing blocks for the Photonics industry including opto- Madison, WI 53719 271 Animal Sciences mechanic, motion control, nano-positioning, fiber Tel: 608-441-2844 Fax: 608-441-2845 1675 Observatory Drive alignment, fiber and optical components, laser diodes, www.takarabiousa.com Madison, WI 53706 tunable lasers, and vibration isolation systems. In Takara Bio USA features Takara Bio's high-perfor- Tel: 608-263-6288 Fax: 608-262-4570 addition to core photonics building blocks, we now mance line of PCR reagents, including real time SYBR www.openmicroscopy.org provide system level solutions including complete Premix Ex Taq™, high fidelity PrimeSTAR™, high The Open Microscopy Environment (OME) Consor- OCT and imaging systems, like confocal and adaptive speed SpeedSTAR™, Ex Taq™, and LA Taq™ (Long tium is committed to developing open source software scanning microscopes. PCR); high-efficiency DNA Ligation Kits; and novel for the storage, analysis, and dissemination of micro- products for Protein Expression and Folding. scope image data within the field of the life sciences. TILL PHOTONICS LLC 923 Current efforts include metadata management tools 411 Trebbiano Place TECAN 507 such as the OME-XML Data Model and Bio-Formats Pleasanton, CA 94560 4022 Stirrup Creek Drive Suite 310 and the OME database servers. 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203 EXHIBITORS The American Society for Cell Biology 47th Annual Meeting December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org

TOCRIS BIOSCIENCE 452 USA SCIENTIFIC INC. 848 VELOCITY 11 732 16144 Westwoods Business Park P.O. Box 3565 3565 Haven Avenue Ellisville, MO 63021 Ocala, FL 34478 Menlo Park, CA 94025 Tel: 800-421-3701 Fax: 800-483-1993 Tel: 352-237-6288 Fax: 352-237-3019 Tel: 650-846-6609 Fax: 650-846-6620 www.tocris.com www.usascientific.com www.volocity11.com The Tocris range contains novel and established USA Scientific provides consumables and tools for Velocity11 broadly covers the life science automation research tools to study signal transduction and neuro- life science research. Products displayed include: market, with a concentration in drug discovery, geno- science; includes protein kinase modulators, cell TipOne® pipet tips; mLINE pipettors; Seal-Rite® mics, and proteomics applications. Through direct dis- cycle/apoptosis tools, G protein reagents, enzyme tubes, Micronic® racked tubes and sealing options; tribution, value added reseller channels, and a multi- modulators, lipid signaling tools and receptor ligands. real-time amplification film and plates; assay plates continent customer service, applications, and support Visit us at www.tocris.com to review our newest prod- and sealing film; freezer racks; storage boxes and organization, Velocity11 strives to deliver an outstand- ucts and to request a copy of our resource-packed cat- labels; gloves; and cell culture products. ing user experience to our customers globally. alog. USB CORPORATION 1428 VIAFLO CORPORATION 1331 TOKAI HIT CO., LTD. 1042 26111 Miles Road 2 Wentworth Drive 306-1 Gendoji-cho Cleveland, OH 44128 Hudson, NH 03051 Fujinomiya-city Shizuoka NA, 418-0074 Japan Tel: 800-321-9322 Fax: 216-464-5075 Tel: 888-578-0111 Fax: 603-577-5529 Tel: 011-81-5442-46699 Fax: 011-81-5442-46641 www.usbweb.com www.viaflo.com www.tokaihit.com USB Corporation, a supplier of biochemicals and An array of liquid handling platforms and consum- New Stage-Top-Incubator introduced! Light and com- molecular biology products to the life sciences com- ables. pact INU for piezo-driven confocal-system, providing munity, offers ExoSAP-IT® for PCR Clean-Up, HotSt- most optimum cell-culture environment; along with art-IT™ and FideliTaq™ DNA Polymerases & Master VISEN MEDICAL, INC. 109 stable focus. 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VisEn's fluorescence 2211 Lewis Avenue Upland, CA 91786 probes and quantitative FMT in vivo imaging system Rockville, MD 20851 Tel: 909-946-3197 Fax: 909-946-3597 are designed to target and quantify a range of disease- Tel: 301-881-2450 Fax: 301-881-5374 www.uvp.com related molecular activites, in areas such as cancer, www.tousimis.com UVP’s BioImaging Systems range from basic BioDoc- inflammation, cardiovascular disease and bone dis- Tousimis manufactures CO2 Critical Point Dryers It™ gel documentation system to advanced BioSpec- ease. enabling delicate micro 3-D structural preservation. trum® Imaging System for chemiluminescent, fluores- Applications are Cytoskeleton, Membrane, Cell and cent, colorimetric, in vivo/in vitro imaging. VISITECH INTERNATIONAL 605 Tissues Organelles, Bio-MEMS, Gel, Polymer-Matrix VisionWorks™ analysis software for comprehensive 15720 John J. Delaney Drive Suite 300 drying. 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Whether your research calls VISTEK, INC. 410 nology seeks to advance life sciences and medicine for high-resolution real-time imaging of in-situ biomo- 4405 East Baseline Road, Suite 120 through the development and application of revolu- lecules under physiologically relevant conditions, pre- Phoenix, AZ 85042 tionary, photon-based tools and techniques. The Cen- cise single molecule measurements of intra- or inter- Tel: 602-426-1211 Fax: 602-426-1611 ter supports a broad portfolio of projects ranging from molecule interactions or combined imaging with AFM www.vistekinc.com advance bioimaging to medical biophotonics. 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204 The American Society for Cell Biology 47th Annual Meeting EXHIBITORS December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org

W.H. FREMAN & COMPANY 215 WHEATON SCIENCE PRODUCTS 913 YSI, INC. 115 41 Madison Avenue 1501 North 10th Street 1700/1725 Brannum Lane New York, NY 10010 Millville, NJ 08332 Yellow Springs, OH 45387 Tel: 212-576-9400 Fax: 212-689-2383 Tel: 856-825-1100 Fax: 856-825-9035 Tel: 937-767-7241 Fax: 937-767-8058 www.whfreeman.com www.wheatonsci.com www.lifesciences.com W.H. Freeman & Company provides high-quality sci- Wheaton Science Products offers a full line of general YSI has a long history in life sciences, most notably ence textbooks and media to the education commu- and specialty life science products; featuring pipettes, with our introduction of the first commercial whole nity. Stop by our booth to review some of our outstand- roller culture systems, tissue grinders, staining dishes, blood glucose analyzer. Our biochemistry analyzers ing titles and eBooks. A few titles on display include: glass and plastic laboratory supplies and Scilutions™ collect critical data during a wide range of chemical Lodish, et al.: Molecular Cell Biology 6/e, Nelson/Cox: – Services that Add Value – Custom Containers, Bar reactions—from byproducts in cell culture fermenta- Lehninger Principles Of Biochemistry 5/e, Berg/ Coding, Tareweighting, Critical Cleaning and Surface tions to sucrose conversion in potatoes to lactate lev- Tymoczko/Stryer: Biochemistry 6/e. Treatment options. els in athletes.

WAFERGEN, INC 443 WICELL RESEARCH INSTITUTE 453 ZEN-BIO, INC. 1230 46571 Fremont Blvd P.O. Box 7365 3200 Chapel Hill-Nelson Blvd Suite 104 Fremont, CA 94538 Madison, WI 53707 RTP, NC 27709 Tel: 510-651-4450 Fax: 510-651-4599 Tel: 608-217-2470 Fax: 608-262-8474 Tel: 919-547-0692 www.wafergen.com www.wicell.org www.zen-bio.com Wafergen, Inc. will display information about The WiCell Research Institute is a non-profit research Zen-Bio was created to meet the urgent need of inves- SmartSlide which is a 6 Well, live-cell imaging system organization supporting hES cell research at the Uni- tigators interested in understanding human obesity, for cellular analysis on any inverted microscope, that versity of Wisconsin-Madison and worldwide. WiCell diabetes, and cardiovascular disease. While rodent is compatible with all commonly used microscopic conducts and supports research at UW-Madison, models are useful for deciphering metabolic pathways imaging techniques. Live cell analysis provides hosts the National Stem Cell Bank, provides training of energy partitioning, the critical analyses for drug insights into cellular physiology that cannot effectively for scientists, and offers educational outreach pro- development in humans requires an appropriate in be achieved using static time point studies. grams for K-12 students and the community. vitro model to study human adipocytes.

WARNER INSTRUMENTS 543 WILEY-BLACKWELL 232 ZYMO RESEARCH CORPORATION 322 1125 Dixwell Avenue 111 River Street 625 West Katella Avenue Suite 30 Hamden, CT 06514 Hoboken, NJ 07030 Orange, CA 92867 Tel: 203-776-0664 Fax: 203-776-1278 Tel: 201-748-6896 Fax: 201-748-6142 Tel: 714-288-9682 Fax: 714-288-9643 www.warneronline.com www.wiley.com www.zymoresearch.com Warner Instruments designs and manufactures low Wiley is a global publisher of professional, consumer, Specializing in the development of technologies for noise Microelectrode amplifiers for patch, bilayer, scientific and technical books, journals, textbooks and DNA/RNA purification and analysis, our goal is to pro- oocyte, and epithelial studies. We also offer a large education materials. Among it's many imprints are the vide the simplest, most reliable tools for DNA, RNA, variety of live cell imaging chambers, temperature world renowned "For Dummies" line as well as Web- and epigenetics research. control systems, and perfusion control systems for use ster's New World, CliffNotes, Frommers, Betty in optical microscopy. New items include microscope Crocker books, and Jossey-Bass. To see more about thermal inserts for 35 mm Petri dishes and cham- these and our other imprints, visit Wiley at www.wi- bered slides. ley.com.

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205 EXHIBITORS The American Society for Cell Biology 47th Annual Meeting December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org

NOTES

206 The American Society for Cell Biology 47th Annual Meeting EXHIBITORS December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org

NOTES

207 EXHIBITORS The American Society for Cell Biology 47th Annual Meeting December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org

NOTES

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2007 © Invitrogen Corporation. All rights reserved. These products may be covered by one or more Limited Use Label Licenses (see the Invitrogen catalog or our website, www.invitrogen.com). Please visit us at booth #623 The American Society for Cell Biology 47th Annual Meeting PRODUCT INDEX December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org

PRODUCT INDEX

A COSMO BIO USA Antiserums EDVOTEK, INC. NEXCELOM BIOSCIENCE ANASPEC, INC. NANOPROBES, INC. Adjuvants CAPRALOGICS, INC. ACCURATE CHEMICAL & Animal cages, metabolism CELPROGEN, INC. Biologicals SCIENTIFIC CORPORATION INGENIOUS TARGETING COSMO BIO USA BIOMATRICA, INC. EMD CHEMICALS, INC. LABORATORY EPITOMICS, INC. CELL SCIENCES, INC. EY LABORATORIES, INC. CELPROGEN, INC. GENOVAC GMBH Affinity purification kits GE HEALTHCARE Animal tissues PRIMMBIOTECH, INC. GENECOPOEIA, INC. AGAROSE BEAD TECHNOLOGIES CELPROGEN, INC. CLONTECH LABORATORIES, INC. LAKE PLACID BIOLOGICALS COSMO BIO USA Autoclaves POLYPLUS-TRANSFECTION COSMO BIO USA COVANCE RESEARCH PRODUCTS EY LABORATORIES, INC. BEL-ART PRODUCTS WORTHINGTON BIOCHEMICAL NEWCOMER SUPPLY MICROBIOLOGY INTERNATIONAL CORPORATION Affinity purified antibodies Animals Automated sample ABD SEROTEC Bio-luminescence INGENIOUS TARGETING BD BIOSCIENCES ABGENT, INC. CELPROGEN, INC. LABORATORY NEXCELOM BIOSCIENCE ABR—AFFINITY BIOREAGENTS LIFESENSORS, INC. RAINDANCE TECHNOLOGIES, INC. ANASPEC, INC. Bioreactors VIAFLO CORPORATION BETHYL LABORATORIES, INC. BELLCO BIOTECHNOLOGY CAPRALOGICS, INC. Antibodies CELPROGEN, INC. CELL SCIENCES, INC. 21st CENTURY BIOCHEMICALS, Automatic samplers FIBERCELL SYSTEMS, INC. CLONTECH LABORATORIES, INC. INC. INTELLICYT, INC. YSI, INC. COSMO BIO USA ABCAM, INC. NEXCELOM BIOSCIENCE CYTOSKELETON, INC. ABD SEROTEC YSI, INC. Biosenors EY LABORATORIES, INC. ABGENT, INC. APPLIED BIOPHYSICS, INC. FABGENNIX INTERNATIONAL. INC. ABR—AFFINITY BIOREAGENTS Autoradiography products BIOFORCE NANOSCIENCES, INC. GENOVAC GMBH ACCURATE CHEMICAL & BEL-ART PRODUCTS DISCOVERX CORPORATION JACKSON IMMUNORESEARCH SCIENTIFIC CORPORATION EVROGEN LABORATORIES, INC. ACTIVE MOTIF, INC. B GE HEALTHCARE LAKE PLACID BIOLOGICALS ADVANCED TARGETING SYSTEMS LC SCIENCES AMERICAN PEPTIDE COMPANY LI-COR BIOSCIENCES Balances ANASPEC, INC. PEPROTECH, INC. QORPAK Biotechnology product PRIMMBIOTECH, INC. AVES LAB, INC. LIFESENSORS, INC. AVIVA SYSTEMS BIOLOGY Biochemical reagents B-BRIDGE INTERNATIONAL, INC. Agarose AMAXA AG Biotin-conjugated BD BIOSCIENCES AGAROSE BEAD TECHNOLOGIES ATCC ABD SEROTEC BETHYL LABORATORIES, INC. CAMBREX RESEARCH PRODUCTS BIOMOL BD BIOSCIENCES BIOLEGEND, INC. (NOW LONZA) CAPRALOGICS, INC. CELL SCIENCES, INC. BIOMOL LONZA (FORMERLY CAMBREX CELL SCIENCES, INC. CELPROGEN, INC. CAPRALOGICS, INC. RESEARCH PRODUCTS) CELPROGEN, INC. ECHELON BIOSCIENCES CAYMAN CHEMICAL COMPANY PROTEA BIOSCIENCES, INC. CYTOSKELETON, INC. EPITOMICS, INC. CEDARLANE LABORATORIES TREVIGEN, INC. GE HEALTHCARE JACKSON IMMUNORESEARCH CELL SCIENCES, INC. USB CORPORATION GLEN RESEARCH CORPORATION LABORATORIES, INC. CELL SIGNALING TECHNOLOGY® GLYCOSAN BIOSYSTEMS, INC. LI-COR BIOSCIENCES CELPROGEN, INC. Alkaline phosphatase PEPTIDES INTERNATIONAL COSMO BIO USA ANASPEC, INC. RESEARCH ORGANICS, INC. Biotinylated antibody COVANCE RESEARCH PRODUCTS BETHYL LABORATORIES, INC. TREVIGEN, INC. ADVANCED TARGETING SYSTEMS CYTOSKELETON, INC. CELL SCIENCES, INC. USB CORPORATION BD BIOSCIENCES EY LABORATORIES, INC. EMD CHEMICALS, INC. CELL SCIENCES, INC. EPITOMICS, INC. JACKSON IMMUNORESEARCH Biochemicals CELPROGEN, INC. LABORATORIES, INC. EY LABORATORIES, INC. CLONTECH LABORATORIES, INC. FIBERCELL SYSTEMS, INC. ADVANCED TARGETING SYSTEMS BIOMOL EPITOMICS, INC. Amino acid resins GENOVAC GMBH PEPROTECH, INC. INVITROGEN C TECHNOLOGIES, INC. ANASPEC, INC. CAYMAN CHEMICAL COMPANY ROCKLAND IMMUNOCHEMICALS, PEPTIDES INTERNATIONAL KINEXUS BIOINFORMATICS INC. CORPORATION CELL SCIENCES, INC. CELPROGEN, INC. Amino acids LAKE PLACID BIOLOGICALS Biotinylated DNA probes LI-COR BIOSCIENCES CLONTECH LABORATORIES, INC. ANASPEC, INC. ECHELON BIOSCIENCES CELPROGEN, INC. LC SCIENCES MITOSCIENCES, INC. ROCKLAND IMMUNOCHEMICALS, NEWCOMER SUPPLY EMD CHEMICALS, INC. RESEARCH ORGANICS, INC. GE HEALTHCARE INC. TOCRIS BIOSCIENCE OPEN BIOSYSTEMS ORIGENE YOUR GENE COMPANY GLYCOSAN BIOSYSTEMS, INC. LC SCIENCES Blenders PEPROTECH, INC. PRO SCIENTIFIC INC. Amplifiers PEPTIDES INTERNATIONAL SIGMA-ALDRICH ALA SCIENTIFIC INSTRUMENTS PRIMMBIOTECH, INC. TOCRIS BIOSCIENCE Blood collecting systems INC. PROMOCELL GMBH USB CORPORATION BD BIOSCIENCES MOLECULAR DEVICES, NOW PART PROTEINTECH GROUP, INC. WORTHINGTON BIOCHEMICAL SARSTEDT, INC. OF MDS ANALYTICAL R&D SYSTEMS, INC. CORPORATION TECHNOLOGIES ROCHE APPLIED SCIENCE WARNER INSTRUMENTS ROCKLAND IMMUNOCHEMICALS, Bioimaging analyzer Blood proteins INC. BD BIOSCIENCES CELPROGEN, INC. Analytical services SIGMA GE HEALTHCARE HARVARD APPARATUS SAMPLE 21st CENTURY BIOCHEMICALS, STRATEGIC DIAGNOSTICS, INC. MBF BIOSCIENCE- PREP INC. TAKARA BIO USA MICROBRIGHTFIELD JACKSON IMMUNORESEARCH ANASPEC, INC. TREVIGEN, INC. LABORATORIES, INC. CAYMAN CHEMICAL COMPANY Biological cultures PAA LABORATORIES, INC., USA MBF BIOSCIENCE- ATCC MICROBRIGHTFIELD Anti-microbial products BIOMATRICA, INC. Blood separation media QUANSYS BIOSCIENCES ANASPEC, INC. CELPROGEN, INC. ACCURATE CHEMICAL & QORPAK SCIENTIFIC CORPORATION Analytical test systems Biological stains and AXIS-SHIELD C TECHNOLOGIES, INC. Antisense DNA probes CELPROGEN, INC. CELPROGEN, INC. CARL ZEISS SMT INC. CELPROGEN, INC. CLONTECH LABORATORIES, INC. GREINER BIO-ONE

209 PRODUCT INDEX The American Society for Cell Biology 47th Annual Meeting December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org

Books and Journals HAMAMATSU PHOTONICS, CELPROGEN, INC. Cell cultures ACADEMIA BOOK EXHIBITS SYSTEMS DIVISION CLONTECH LABORATORIES, INC. ATCC ADVANTAGE BUSINESS MEDIA INTELLIGENT IMAGING COVALYS BIOSCIENCES AG B-BRIDGE INTERNATIONAL, INC. AMERICAN BIOTECHNOLOGY INNOVATIONS DISCOVERX CORPORATION BD BIOSCIENCES LABORATORY LUMENERA CORPORATION FLEXCELL INTERNATIONAL BIOLOGIX RESEARCH COMPANY AMERICAN SOCIETY FOR OLYMPUS AMERICA INC. CORPORATION CELPROGEN, INC. BIOCHEMISTRY AND PHOTOMETRICS GENE TOOLS, LLC LIFELINE CELL TECHNOLOGY MOLECULAR QIMAGING GENETIX MEDIATECH, INC. BIOLOGY STANFORD PHOTONICS INC. INAMED BIOMATERIALS PLATYPUS TECHNOLOGIES AMERICAN SOCIETY FOR UVP, LLC LIFELINE CELL TECHNOLOGY PROMOCELL GMBH INVESTIGATIVE PATHOLOGY LIFESENSORS, INC. R&D SYSTEMS, INC. BENJAMIN CUMMINGS Cameras, digital systems LONZA (FORMERLY CAMBREX SYSTEM BIOSCIENCES (SBI) BIOCOMPARE ANDOR TECHNOLOGY RESEARCH PRODUCTS) WAFERGEN, INC BIOMED CENTRAL APOGEE INSTRUMENTS, INC. NANOPOINT, INC. WICELL RESEARCH INSTITUTE BIOPHOTONICS INTERNATIONAL CARL ZEISS MICROIMAGING, INC. NANOPROBES, INC. ZEN-BIO, INC. CEDARLANE LABORATORIES COOKE CORPORATION, THE OPEN BIOSYSTEMS CELL PRESS DIAGNOSTIC INSTRUMENTS,INC. PLATYPUS TECHNOLOGIES Cell disruption equipment COLD SPRING HARBOR DVC COMPANY POLYPLUS-TRANSFECTION CONSTANT SYSTEMS LABORATORY PRESS HAMAMATSU PHOTONICS, PROMOCELL GMBH INCORPORATED ELSEVIER SYSTEMS DIVISION ROCHE APPLIED SCIENCE SCIENTIFIC INDUSTRIES, INC. ELSEVIER INC. LEICA MICROSYSTEMS SOLAMERE TECHNOLOGY GROUP, GARLAND SCIENCE /TAYLOR & LUMENERA CORPORATION INC. Cell fusion equipment FRANCIS NIKON INSTRUMENTS INC. TOCRIS BIOSCIENCE BTX/HARVARD APPARATUS JONES & BARTLETT PUBLISHERS OLYMPUS AMERICA INC. TOKAI HIT CO., LTD. MARINE BIOLOGICAL SOLAMERE TECHNOLOGY GROUP, TREVIGEN, INC. Cell harvester LABORATORY (MBL) INC. UC DAVIS CENTER FOR MOLECULAR DEVICES, NOW PART NATIONAL INSTITUTE OF STANFORD PHOTONICS INC. BIOPHOTONICS, SCIENCE & OF MDS ANALYTICAL GENERAL MEDICAL SCIENCES TECHNOLOGY TECHNOLOGIES (NIGMS) Cameras, specialty CCD USA SCIENTIFIC INC. NATURE PUBLISHING GROUP APOGEE INSTRUMENTS, INC. WHEATON SCIENCE PRODUCTS Cell membrane labeling PNAS (PROCEEDINGS OF THE COOKE CORPORATION, THE WORTHINGTON BIOCHEMICAL A SLICE OF LIFE NATIONAL ACADEMY OF DIAGNOSTIC INSTRUMENTS, INC. CORPORATION CELPROGEN, INC. SCIENCES) DVC COMPANY ZEN-BIO, INC. CLONTECH LABORATORIES, INC. SELECTSCIENCE HAMAMATSU PHOTONICS, COVALYS BIOSCIENCES AG THE AMERICAN ASSOCIATION OF SYSTEMS DIVISION Cell culture apparatus GENETIX IMMUNOLOGISTS LEICA MICROSYSTEMS ADVANGENE CONSUMABLES, INC. THE COMPANY OF BIOLOGISTS OLYMPUS AMERICA INC. APPLIED BIOPHYSICS, INC. Cell microfluorometer LTD. STANFORD PHOTONICS INC. B-BRIDGE INTERNATIONAL, INC. HORIBA JOBIN YVON INC. THE ROCKEFELLER UNIVERSITY BEL-ART PRODUCTS PRESS Carboyhdrates CELLASIC CORPORATION Cell separater THE SCIENTIST ACCURATE CHEMICAL & CELPROGEN, INC. MILTENYI BIOTEC, INC. W.H. FREMAN & COMPANY SCIENTIFIC CORPORATION FIBERCELL SYSTEMS, INC. WILEY-BLACKWELL EY LABORATORIES, INC. FLEXCELL INTERNATIONAL Cell separation medium PEPTIDES INTERNATIONAL CORPORATION ACCURATE CHEMICAL & SCIENTIFIC CORPORATION Buffers PLATYPUS TECHNOLOGIES AXIS-SHIELD CELPROGEN, INC. Carts, laboratory TOKAI HIT CO., LTD. CEDARLANE LABORATORIES CLONTECH LABORATORIES, INC. THORLABS WAFERGEN, INC CELPROGEN, INC. LI-COR BIOSCIENCES WHEATON SCIENCE PRODUCTS CDNA probes CLONTECH LABORATORIES, INC. NEWCOMER SUPPLY OPEN BIOSYSTEMS GE HEALTHCARE PROTEA BIOSCIENCES, INC. ORIGENE YOUR GENE COMPANY Cell culture bags GREINER BIO-ONE QORPAK SYSTEM BIOSCIENCES (SBI) BELLCO BIOTECHNOLOGY INVITROGEN RESEARCH ORGANICS, INC. LAMPIRE BIOLOGICAL MEDIATECH, INC. TOUSIMIS CDNA systems LABORATORIES, INC. APPLIED BIOSYSTEMS MEDIATECH, INC. Cell sorters CELPROGEN, INC. MILTENYI BIOTEC, INC. BD BIOSCIENCES C EVROGEN GENETIX GENECOPOEIA, INC. Cell culture carrier MILTENYI BIOTEC, INC. Cameras, CCD MILTENYI BIOTEC, INC. BELLCO BIOTECHNOLOGY ANDOR TECHNOLOGY OPEN BIOSYSTEMS CELPROGEN, INC. Cell transfer systems APOGEE INSTRUMENTS, INC. ORIGENE YOUR GENE COMPANY INAMED BIOMATERIALS CLONTECH LABORATORIES, INC. ASI/APPLIED SCIENTIFIC PROMEGA CORPORATION MEDIATECH, INC. DIGITAL BIO INSTRUMENTATION SYSTEM BIOSCIENCES (SBI) WAFERGEN, INC COOKE CORPORATION, THE Centrifugation media and DIAGNOSTIC INSTRUMENTS, INC. Cell adhesion molecules Cell culture media AXIS-SHIELD DVC COMPANY BD BIOSCIENCES AMAXA AG HAMAMATSU PHOTONICS, CELL BIOLABS, INC. ATCC Centrifuge tubes SYSTEMS DIVISION CELL SCIENCES, INC. BD BIOSCIENCES ADVANGENE CONSUMABLES, INC. HORIBA JOBIN YVON INC. CELPROGEN, INC. CAMBREX RESEARCH PRODUCTS BEL-ART PRODUCTS Ibidi LLC CLONTECH LABORATORIES, INC. (NOW LONZA) BIOLOGIX RESEARCH COMPANY LEICA MICROSYSTEMS CYTOSKELETON, INC. CELPROGEN, INC. CORNING INCORPORATED LUMENERA CORPORATION INAMED BIOMATERIALS CLONTECH LABORATORIES, INC. GREINER BIO-ONE MOLECULAR DEVICES, NOW PART GE HEALTHCARE QORPAK OF MDS ANALYTICAL Cell biology products GENETIX SARSTEDT, INC. TECHNOLOGIES ACTIVE MOTIF, INC. GLYCOSAN BIOSYSTEMS, INC. USA SCIENTIFIC INC. OLYMPUS AMERICA INC. ADVANGENE CONSUMABLES, INC. Ibidi LLC PHOTOMETRICS APPLIED BIOPHYSICS, INC. INAMED BIOMATERIALS Centrifuges QIMAGING ATCC INVITROGEN EPPENDORF NORTH AMERICA STANFORD PHOTONICS INC. BD BIOSCIENCES LIFELINE CELL TECHNOLOGY PRO SCIENTIFIC INC. THORLABS BIOFORCE NANOSCIENCES, INC. LONZA (FORMERLY CAMBREX QORPAK BIOLEGEND, INC. RESEARCH PRODUCTS) SAKURA FINETEK USA Cameras, cooled CCD BIOMATRICA, INC. MEDIATECH, INC. SARSTEDT, INC. ANDOR TECHNOLOGY BIOMOL MO BIO LABORATORIES USA SCIENTIFIC INC. APOGEE INSTRUMENTS, INC. CAMBREX RESEARCH PRODUCTS PAA LABORATORIES, INC., USA COOKE CORPORATION, THE (NOW LONZA) PROMOCELL GMBH Chemicals DIAGNOSTIC INSTRUMENTS,INC. CELL BIOLABS, INC. SIGMA-ALDRICH BIOMOL DVC COMPANY CELL KINETICS, LTD. WAFERGEN, INC GE HEALTHCARE FUJIFILM LIFE SCIENCE, USA CELL SIGNALING TECHNOLOGY® ZEN-BIO, INC. NEWCOMER SUPPLY

210 The American Society for Cell Biology 47th Annual Meeting PRODUCT INDEX December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org

RESEARCH ORGANICS, INC. Conjugation of antibodies OPEN BIOSYSTEMS MBF BIOSCIENCE- SIGMA-ALDRICH ADVANCED TARGETING SYSTEMS PRIMMBIOTECH, INC. MICROBRIGHTFIELD TOCRIS BIOSCIENCE BIOLEGEND, INC. ROCKLAND IMMUNOCHEMICALS, MOLECULAR DEVICES, NOW PART TOUSIMIS CELPROGEN, INC. INC. OF MDS ANALYTICAL NANOPROBES, INC. TECHNOLOGIES Chemiluminescence ROCKLAND IMMUNOCHEMICALS, Custom PCR service NATIONAL CENTER FOR APPLIED BIOSYSTEMS INC. EVROGEN BIOTECHNOLOGY BD BIOSCIENCES GENEWIZ, INC. INFORMATION GE HEALTHCARE Contract and R&D SYSTEM BIOSCIENCES (SBI) THE OPEN MICROSCOPY MILLIPORE BIOLYPH LLC ENVIRONMENT ROCKLAND IMMUNOCHEMICALS, CELPROGEN, INC. Custom peptides TITIAN SOFTWARE INC. CYTOSKELETON, INC. 21st CENTURY BIOCHEMICALS, EVROGEN INC. Data processing systems Chromatograph tubes or GENEWIZ, INC. AMERICAN PEPTIDE COMPANY BITPLANE, INC. CLONTECH LABORATORIES, INC. LATHROP ENGINEERING INC ANASPEC, INC. MOLECULAR DEVICES, NOW PART MBF BIOSCIENCE- BIOMOL OF MDS ANALYTICAL MICROBRIGHTFIELD Chromatographs, affinity, CELL SCIENCES, INC. TECHNOLOGIES NANOPROBES, INC. AGAROSE BEAD TECHNOLOGIES COVANCE RESEARCH PRODUCTS THE OPEN MICROSCOPY CLONTECH LABORATORIES, INC. LAMPIRE BIOLOGICAL ENVIRONMENT Control serums LABORATORIES, INC. LAMPIRE BIOLOGICAL PEPTIDES INTERNATIONAL Data retrieval Chromatographs, liquid, LABORATORIES, INC. WHEATON SCIENCE PRODUCTS PRIMMBIOTECH, INC. BIOTRUE INC. TITIAN SOFTWARE Controlled rate freezers Chromatography columns Custom screening Ibidi LLC AMERICAN PEPTIDE COMPANY Densitometers BEL-ART PRODUCTS SP INDUSTRIES CLONTECH LABORATORIES, INC. BIOMOL MBF BIOSCIENCE- GE HEALTHCARE CELPROGEN, INC. MICROBRIGHTFIELD Cryofixation instrumentation GENEWIZ, INC. NORGEN BIOTEK CORPORATION BOECKELER INSTRUMENTS, INC. PROTEA BIOSCIENCES, INC. HIGH THROUGHPUT GENOMICS Desiccators LC SCIENCES BEL-ART PRODUCTS Cryogenic storage ORIGENE YOUR GENE COMPANY Chromatography systems BEL-ART PRODUCTS QUANSYS BIOSCIENCES GE HEALTHCARE BIOLOGIX RESEARCH COMPANY Detection systems GE HEALTHCARE Cryogenic vials Custom synthesis LI-COR BIOSCIENCES Clean room products ADVANCED TARGETING SYSTEMS MOLECULAR DEVICES, NOW PART THORLABS BIOHIT, INC. CORNING INCORPORATED AMERICAN PEPTIDE COMPANY OF MDS ANALYTICAL GREINER BIO-ONE ANASPEC, INC. TECHNOLOGIES Clinical diagnostic aids APPLIED BIOSYSTEMS NANOPROBES, INC. BIOLYPH LLC Ibidi LLC USA SCIENTIFIC INC. BIOMOL PROMEGA CORPORATION WHEATON SCIENCE PRODUCTS CAYMAN CHEMICAL COMPANY Cloning vectors CELPROGEN, INC. Detectors, light CLONTECH LABORATORIES, INC. Cryostats GENECOPOEIA, INC. ANDOR TECHNOLOGY EMD Chemicals, Inc. LEICA MICROSYSTEMS GLEN RESEARCH CORPORATION HAMAMATSU PHOTONICS, EVROGEN SAKURA FINETEK USA LC SCIENCES SYSTEMS DIVISION GENECOPOEIA, INC. NANOPROBES, INC. STANFORD PHOTONICS INC. NEW ENGLAND BIOLABS, INC. Cryosubstitution PEPTIDES INTERNATIONAL ORIGENE YOUR GENE COMPANY BOECKELER INSTRUMENTS, INC. Diagnostic aids PROMEGA CORPORATION Cuvettes, plastic BEL-ART PRODUCTS Cryoultramicrotome BEL-ART PRODUCTS CELPROGEN, INC. Colloidal gold complexes BOECKELER INSTRUMENTS, INC. BRANDTECH SCIENTIFIC, INC. EY LABORATORIES, INC. LEICA MICROSYSTEMS BTX/HARVARD APPARATUS Diagnostic monoclonal JACKSON IMMUNORESEARCH SARSTEDT, INC. BD BIOSCIENCES LABORATORIES, INC. Culture apparatus USA SCIENTIFIC INC. LAMPIRE BIOLOGICAL NANOPROBES, INC. CELPROGEN, INC. LABORATORIES, INC. TOKAI HIT CO., LTD. Cytokines Colony counters APOLLO CYTOKINE RESEARCH Diagnostic serums BEL-ART PRODUCTS Culture media B-BRIDGE INTERNATIONAL, INC. CAPRALOGICS, INC. MICROBIOLOGY INTERNATIONAL ATCC BD BIOSCIENCES BD BIOSCIENCES BIOLEGEND, INC. Diagnostic test kits Column packing CELPROGEN, INC. CEDARLANE LABORATORIES CELPROGEN, INC. GE HEALTHCARE LIFELINE CELL TECHNOLOGY CELL SCIENCES, INC. EDVOTEK, INC. MEDIATECH, INC. CELPROGEN, INC. LIFESENSORS, INC. Competent cells HIGH THROUGHPUT GENOMICS PEPROTECH, INC. ATCC Cultured cells Dialysis equipment PROMOCELL GMBH CELPROGEN, INC. ACCURATE CHEMICAL & ACCURATE CHEMICAL & PROMEGA CORPORATION SCIENTIFIC CORPORATION SCIENTIFIC CORPORATION ZYMO RESEARCH CORPORATION ATCC CELPROGEN, INC. D DISCOVERX CORPORATION Diamond knives Complement GENE TOOLS, LLC Data acquisition BOECKELER INSTRUMENTS, INC. CEDARLANE LABORATORIES LIFELINE CELL TECHNOLOGY MOLECULAR DEVICES, NOW PART ELECTRON MICROSCOPY OF MDS ANALYTICAL SCIENCES/DIATOME U.S. Computer-3-D Custom antibody TECHNOLOGIES LEICA MICROSYSTEMS BITPLANE, INC. ABD SEROTEC NANOPOINT, INC. CARL ZEISS MICROIMAGING, INC. ABGENT, INC. TITIAN SOFTWARE Digitizer MBF BIOSCIENCE- ABR—AFFINITY BIOREAGENTS MOLECULAR DEVICES, NOW PART MICROBRIGHTFIELD ANASPEC, INC. Data acquisition equipment OF MDS ANALYTICAL VISITECH INTERNATIONAL BD BIOSCIENCES APPLIED BIOPHYSICS, INC. TECHNOLOGIES BETHYL LABORATORIES, INC. BIOSCIENCE TOOLS Computers BIOMOL MOLECULAR DEVICES, NOW PART Diluters, automatic MBF BIOSCIENCE- CAPRALOGICS, INC. OF MDS ANALYTICAL MICROBIOLOGY INTERNATIONAL MICROBRIGHTFIELD CELL SCIENCES, INC. TECHNOLOGIES CELPROGEN, INC. Dispenser, automatic Conferences COVANCE RESEARCH PRODUCTS Data analysis software WHEATON SCIENCE PRODUCTS SELECTSCIENCE GENOVAC GMBH BITPLANE, INC. THE AMERICAN ASSOCIATION OF LAMPIRE BIOLOGICAL DIAGNOSTIC INSTRUMENTS, INC. Dissecting microscopes IMMUNOLOGISTS LABORATORIES, INC. INTELLICYT, INC. LEICA MICROSYSTEMS

211 PRODUCT INDEX The American Society for Cell Biology 47th Annual Meeting December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org

DNA assay kits CLONTECH LABORATORIES, INC. Electron microscopes Employment CELL BIOLABS, INC. GE HEALTHCARE A SLICE OF LIFE CINCINNATI CHILDREN'S CELPROGEN, INC. GENEWIZ, INC. HITACHI HIGH TECHNOLOGIES RESEARCH FOUNDATION CLONTECH LABORATORIES, INC. ROCHE APPLIED SCIENCE AMERICA MARINE BIOLOGICAL MOLECULAR DEVICES, NOW PART JEOL USA, INC. LABORATORY (MBL) OF MDS ANALYTICAL DNA sequence analysis NATIONAL INSTITUTE OF ALLERGY TECHNOLOGIES DNASTAR, INC. Electron optics AND INFECTIOUS DISEASES TEL-TEST, INC. JEOL USA, INC. SELECTSCIENCE TREVIGEN, INC. DNA sequencer WASHINGTON UNIVERSITY IN ST. ADVANGENE CONSUMABLES, INC. Electrophoresis LOUIS, OFFICE OF POST DNA assay system APPLIED BIOSYSTEMS GE HEALTHCARE GRADUATE AFFAIRS CELPROGEN, INC. GE HEALTHCARE LI-COR BIOSCIENCES CLONTECH LABORATORIES, INC. RAINDANCE TECHNOLOGIES, INC. Environmental chambers GENEWIZ, INC. ROCHE APPLIED SCIENCE 20/20 TECHNOLOGY, INC. INVITROGEN Electrophoresis equipment ALA SCIENTIFIC INSTRUMENTS LC SCIENCES ACCURATE CHEMICAL & INC. DNA synthesis SCIENTIFIC CORPORATION RAINDANCE TECHNOLOGIES, INC. CLONTECH LABORATORIES, INC. NANOPOINT, INC. EDVOTEK, INC. OKOLAB: LIVE CELL MICROSCOPY GE HEALTHCARE GE HEALTHCARE DNA concentrators GENECOPOEIA, INC. PRECISION PLASTICS, INC. CLONTECH LABORATORIES, INC. MOLECULAR DEVICES, NOW PART TOKAI HIT CO., LTD. GENOVAC GMBH OF MDS ANALYTICAL SP INDUSTRIES GLEN RESEARCH CORPORATION ZYMO RESEARCH CORPORATION TECHNOLOGIES Environmental monitors PROTEA BIOSCIENCES, INC. MICROBIOLOGY INTERNATIONAL DNA fingerprinting DNA vectors STOVALL LIFE SCIENCE, INC. BTX/HARVARD APPARATUS TAKARA BIO USA CORIELL CELL REPOSITORIES Enzyme analyzers CLONTECH LABORATORIES, INC. USA SCIENTIFIC INC. EDVOTEK, INC. RAINDANCE TECHNOLOGIES, INC. PROMEGA CORPORATION UVP, LLC SYSTEM BIOSCIENCES (SBI) DNA isolation kits and Enzyme immunoassay APPLIED BIOSYSTEMS Electrophoresis media, Dyes and labeling reagents ACTIVE MOTIF, INC. BIOMATRICA, INC. CAMBREX RESEARCH PRODUCTS B-BRIDGE INTERNATIONAL, INC. BRANDTECH SCIENTIFIC, INC. ACCURATE CHEMICAL & (NOW LONZA) SCIENTIFIC CORPORATION BD BIOSCIENCES CELPROGEN, INC. GE HEALTHCARE BIOHIT, INC. CLONTECH LABORATORIES, INC. ANASPEC, INC. INVITROGEN CELPROGEN, INC. BIOMOL GE HEALTHCARE LONZA (FORMERLY CAMBREX CAYMAN CHEMICAL COMPANY MO BIO LABORATORIES COVALYS BIOSCIENCES AG RESEARCH PRODUCTS) MIRUS BIO CORPORATION LIFESENSORS, INC. MOLECULAR DEVICES, NOW PART PROTEA BIOSCIENCES, INC. MITOSCIENCES, INC. OF MDS ANALYTICAL MOLECULAR DEVICES, NOW PART OF MDS ANALYTICAL OLINK BIOSCIENCE TECHNOLOGIES Electrophoresis size QUANSYS BIOSCIENCES NORGEN BIOTEK CORPORATION TECHNOLOGIES NEWCOMER SUPPLY NEW ENGLAND BIOLABS, INC. R&D SYSTEMS, INC. PROMEGA CORPORATION ROCKLAND IMMUNOCHEMICALS, PROMOCELL GMBH PROMOCELL GMBH Electrophoresis, high INC. ROCHE APPLIED SCIENCE ROCKLAND IMMUNOCHEMICALS, GE HEALTHCARE TEL-TEST, INC. INC. NANONICS IMAGING LTD. Enzyme inhibitors ZYMO RESEARCH CORPORATION ANASPEC, INC. BIOMOL DNA libraries E Electrophysiological CELL SCIENCES, INC. BIOMATRICA, INC. ALA SCIENTIFIC INSTRUMENTS EMD Chemicals, Inc. CELPROGEN, INC. Educational materials INC. TOCRIS BIOSCIENCE EVROGEN 21st CENTURY BIOCHEMICALS, IONSCOPE LIMITED GENEWIZ, INC. INC. NANONICS IMAGING LTD. LC SCIENCES AMERICAN BIOTECHNOLOGY SUTTER INSTRUMENT COMPANY Enzyme reagents OPEN BIOSYSTEMS LABORATORY WARNER INSTRUMENTS BIOMOL SYSTEM BIOSCIENCES (SBI) AMERICAN FRIENDS OF THE CELL SCIENCES, INC. ALEXANDER VON HUMBOLDT Electroporation system CLONTECH LABORATORIES, INC. DNA modification reagents FOUNDATION AMAXA AG DISCOVERX CORPORATION CELPROGEN, INC. AMERICAN SOCIETY FOR APPLIED BIOPHYSICS, INC. EY LABORATORIES, INC. CLONTECH LABORATORIES, INC. INVESTIGATIVE PATHOLOGY DIGITAL BIO GE HEALTHCARE Evrogen JSC APPLIED BIOPHYSICS, INC. MOLECULAR DEVICES, NOW PART RESEARCH ORGANICS, INC. GLEN RESEARCH CORPORATION EDVOTEK, INC. OF MDS ANALYTICAL USB CORPORATION NEW ENGLAND BIOLABS, INC. MARINE BIOLOGICAL TECHNOLOGIES LABORATORY (MBL) Enzyme substrates NATIONAL CENTER FOR ANASPEC, INC. DNA probes Electropulsing unit BIOTECHNOLOGY BIOMOL APPLIED BIOSYSTEMS BTX/HARVARD APPARATUS CELPROGEN, INC. INFORMATION CELL SCIENCES, INC. NATIONAL INSTITUTE OF CHILD EMD Chemicals, Inc. GE HEALTHCARE Elisa plates/strips MOLECULAR DEVICES, NOW PART HEALTH AND HUMAN LAKE PLACID BIOLOGICALS DEVELOPMENT (NICHD) ADVANGENE CONSUMABLES, INC. PEPTIDES INTERNATIONAL OF MDS ANALYTICAL APOLLO CYTOKINE RESEARCH TECHNOLOGIES NATIONAL INSTITUTE OF HEALTH, OFFICE OF INTRAMURAL BD BIOSCIENCES Enzymes BIOLEGEND, INC. DNA purification kits TRAINING AND EDUCATION BIOMOL BRANDTECH SCIENTIFIC, INC. AVEGENE LIFE SCIENCE NIH STEM CELL INFORMATION CELL SCIENCES, INC. CELL SCIENCES, INC. B-BRIDGE INTERNATIONAL, INC. THE SCIENTIST CYTOSKELETON, INC. ECHELON BIOSCIENCES CELPROGEN, INC. WASHINGTON UNIVERSITY IN ST. ECHELON BIOSCIENCES GREINER BIO-ONE CLONTECH LABORATORIES, INC. LOUIS, OFFICE OF POST EMD Chemicals, Inc. PROMOCELL GMBH EDVOTEK, INC. GRADUATE AFFAIRS LIFESENSORS, INC. QUANSYS BIOSCIENCES GE HEALTHCARE PROMEGA CORPORATION TAKARA BIO USA MO BIO LABORATORIES Electrodes PROTEA BIOSCIENCES, INC. MOLECULAR DEVICES, NOW PART ALA SCIENTIFIC INSTRUMENTS ROCHE APPLIED SCIENCE OF MDS ANALYTICAL INC. Elisa testing TREVIGEN, INC. TECHNOLOGIES APPLIED BIOPHYSICS, INC. BD BIOSCIENCES USB CORPORATION ORIGENE YOUR GENE COMPANY BTX/HARVARD APPARATUS GENWAY BIOTECH, INC. WORTHINGTON BIOCHEMICAL TAKARA BIO USA QUANSYS BIOSCIENCES CORPORATION TEL-TEST, INC. Electron micrography ZYMO RESEARCH CORPORATION TOUSIMIS Eliza plates, specialty Evaporators, vacuum ADVANGENE CONSUMABLES, INC. SP INDUSTRIES DNA quantification Electron microscope APOLLO CYTOKINE RESEARCH ADVANGENE CONSUMABLES, INC. A SLICE OF LIFE BIOLOGIX RESEARCH COMPANY Exotoxins APPLIED BIOSYSTEMS NANOPROBES, INC. GENWAY BIOTECH, INC. CELL SCIENCES, INC.

212 The American Society for Cell Biology 47th Annual Meeting PRODUCT INDEX December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org

Expression vectors Fluorescence filter sets RAINDANCE TECHNOLOGIES, INC. Glassware custom-made AMAXA AG ASAHI SPECTRA USA INC. SVISION LLC BELLCO BIOTECHNOLOGY CLONTECH LABORATORIES, INC. BD BIOSCIENCES DRUMMOND SCIENTIFIC DISCOVERX CORPORATION CHROMA TECHNOLOGY Fluorescent antibody EVROGEN GENECOPOEIA, INC. CORPORATION 21st CENTURY BIOCHEMICALS, Glassware dryers LIFESENSORS, INC. MAG BIOSYSTEMS INC. SP INDUSTRIES MIRUS BIO CORPORATION OMEGA OPTICAL, INC. ABD SEROTEC NEW ENGLAND BIOLABS, INC. SEMROCK, INC. ADVANCED TARGETING SYSTEMS Glassware micro lambda PROMEGA CORPORATION THORLABS BD BIOSCIENCES DRUMMOND SCIENTIFIC ROCHE APPLIED SCIENCE CELL SIGNALING TECHNOLOGY® TAKARA BIO USA Fluorescence microscopy EY LABORATORIES, INC. Glove boxes CARL ZEISS MICROIMAGING, INC. JACKSON IMMUNORESEARCH BEL-ART PRODUCTS Extracellular matrix COOLLED LTD LABORATORIES, INC. MO BIO LABORATORIES ACCURATE CHEMICAL & EXFO LIFE SCIENCE & LAKE PLACID BIOLOGICALS SCIENTIFIC CORPORATION INDUSTRIAL DIVISION NANOPROBES, INC. Growth factors BD BIOSCIENCES LEICA MICROSYSTEMS AMERICAN PEPTIDE COMPANY CEDARLANE LABORATORIES POINT SOURCE Fluorescent particles APOLLO CYTOKINE RESEARCH CELL BIOLABS, INC. PRIOR SCIENTIFIC, INC. ACTIVE MOTIF, INC. BD BIOSCIENCES GLYCOSAN BIOSYSTEMS, INC. SUTTER INSTRUMENT COMPANY CELL SCIENCES, INC. INAMED BIOMATERIALS Fluorometers PEPROTECH, INC. LIFECORE BIOMEDICAL, INC. Fluorescence reagents HORIBA JOBIN YVON INC. PROMOCELL GMBH R&D SYSTEMS, INC. ACTIVE MOTIF, INC. INVITROGEN R&D SYSTEMS, INC. ROCKLAND IMMUNOCHEMICALS, ANASPEC, INC. ISS INC. BD BIOSCIENCES LIGHTFORM, INC. H COVALYS BIOSCIENCES AG NANODROP TECHNOLOGIES, INC. F CYTOSKELETON, INC. Hand protectors ECHELON BIOSCIENCES Fraction collectors, liquid BEL-ART PRODUCTS GE HEALTHCARE Fermentation equipment EVROGEN BELLCO BIOTECHNOLOGY EY LABORATORIES, INC. Homogenizers, tissue GENECOPOEIA, INC. Freeze drying equipment MO BIO LABORATORIES SP INDUSTRIES Fetal bovine GENETIX OMNI INTERNATIONAL: THE GLEN RESEARCH CORPORATION HOMOGENIZER COMPANY PAA LABORATORIES, INC., USA Freeze fracture USA SCIENTIFIC INC. INVITROGEN PRO SCIENTIFIC INC. LAKE PLACID BIOLOGICALS BOECKELER INSTRUMENTS, INC. MIRUS BIO CORPORATION Hoods Filter bottom plates Freezer racks MILLIPORE PROMOCELL GMBH BEL-ART PRODUCTS RESEARCH ORGANICS, INC. USA SCIENTIFIC INC. NUAIRE, INC. Filter membranes SYSTEM BIOSCIENCES (SBI) Freezers Hot plates GE HEALTHCARE NUAIRE, INC. MILLIPORE Fluorescence systems CORNING INCORPORATED ACCURI CYTOMETERS, INC. Ibidi LLC Filter paper COOLLED LTD G OKOLAB: Live Cell Microscopy MILLIPORE EXFO LIFE SCIENCE & PRO SCIENTIFIC INC. INDUSTRIAL DIVISION Gel electrophoresis QORPAK Filter pipet tips FUJIFILM LIFE SCIENCE, USA FUJIFILM LIFE SCIENCE, USA TOKAI HIT CO., LTD. BIOHIT, INC. GE HEALTHCARE GE HEALTHCARE EPPENDORF NORTH AMERICA HAMAMATSU PHOTONICS, PROTEA BIOSCIENCES, INC. HPLC column GREINER BIO-ONE SYSTEMS DIVISION USA SCIENTIFIC INC. GE HEALTHCARE SARSTEDT, INC. HORIBA JOBIN YVON INC. UVP, LLC USA SCIENTIFIC INC. ISS HPLC peptide standards VIAFLO CORPORATION LI-COR BIOSCIENCES Gel extraction kit 21st CENTURY BIOCHEMICALS, VISTALAB TECHNOLOGIES, INC. LIGHTFORM, INC. MO BIO LABORATORIES INC. MAG BIOSYSTEMS NORGEN BIOTEK CORPORATION AMERICAN PEPTIDE COMPANY Filters MBF BIOSCIENCE- ZYMO RESEARCH CORPORATION Hybridization ADVANGENE CONSUMABLES, INC. MICROBRIGHTFIELD MILTENYI BIOTEC, INC. ASAHI SPECTRA USA INC. MOLECULAR DEVICES, NOW PART Gene cloning and STOVALL LIFE SCIENCE, INC. CHROMA TECHNOLOGY OF MDS ANALYTICAL DISCOVERX CORPORATION UVP, LLC CORPORATION TECHNOLOGIES DNASTAR, INC. CVI MELLES GRIOT NANONICS IMAGING LTD. GENECOPOEIA, INC. Hybridization reagents MILLIPORE NIKON INSTRUMENTS INC. GENEWIZ, INC. MIRUS BIO CORPORATION OMEGA OPTICAL, INC. OKOLAB: LIVE CELL MICROSCOPY LENTIGEN OLYMPUS AMERICA INC. QORPAK MIRUS BIO CORPORATION Hybridomas SEMROCK, INC. PHOTONIC INSTRUMENTS, INC. NEW ENGLAND BIOLABS, INC. PHOTRON ABGENT, INC. ORIGENE YOUR GENE COMPANY ANASPEC, INC. Flow cytometer POINT SOURCE ROCHE APPLIED SCIENCE SVISION LLC BTX/HARVARD APPARATUS ACCURI CYTOMETERS, INC. COVANCE RESEARCH PRODUCTS BD BIOSCIENCES UVP, LLC Genomic DNA purification VISITECH INTERNATIONAL GENETIX RAINDANCE TECHNOLOGIES, INC. BIOMATRICA, INC. GENOVAC GMBH CLONTECH LABORATORIES, INC. LAMPIRE BIOLOGICAL Flow cytometry reagents Fluorescence systems, GE HEALTHCARE LABORATORIES, INC. ABD SEROTEC BD BIOSCIENCES MO BIO LABORATORIES ACCURI CYTOMETERS, INC. CELL KINETICS, LTD. NORGEN BIOTEK CORPORATION ADVANCED TARGETING SYSTEMS CLONTECH LABORATORIES, INC. ROCHE APPLIED SCIENCE I BD BIOSCIENCES DVC COMPANY USB CORPORATION BIOLEGEND, INC. EXFO LIFE SCIENCE & ZYMO RESEARCH CORPORATION Image analysis CELL SCIENCES, INC. INDUSTRIAL DIVISION A SLICE OF LIFE CELL SIGNALING TECHNOLOGY® HAMAMATSU PHOTONICS, Genomic DNAs ANDOR TECHNOLOGY COVALYS BIOSCIENCES AG SYSTEMS DIVISION BIOMATRICA, INC. ASI/APPLIED SCIENTIFIC INVITROGEN HORIBA JOBIN YVON INC. GENEWIZ, INC. INSTRUMENTATION JACKSON IMMUNORESEARCH LEICA MICROSYSTEMS OPEN BIOSYSTEMS BD BIOSCIENCES LABORATORIES, INC. LIGHTFORM, INC. BITPLANE, INC. MILTENYI BIOTEC, INC. MAG BIOSYSTEMS Glassware CELL KINETICS, LTD. ROCKLAND IMMUNOCHEMICALS, MBF BIOSCIENCE- BELLCO BIOTECHNOLOGY CHROMODYNAMICS, INC. INC. MICROBRIGHTFIELD CORNING INCORPORATED FUJIFILM LIFE SCIENCE, USA NANODROP TECHNOLOGIES, INC. QORPAK GE HEALTHCARE Flow cytometry standards NIKON INSTRUMENTS INC. SP INDUSTRIES INTELLIGENT IMAGING BD BIOSCIENCES PHOTRON WHEATON SCIENCE PRODUCTS INNOVATIONS

213 PRODUCT INDEX The American Society for Cell Biology 47th Annual Meeting December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org

LEICA MICROSYSTEMS NANOPOINT, INC. In situ KINEXUS BIOINFORMATICS LI-COR BIOSCIENCES PHOTRON C TECHNOLOGIES, INC. CORPORATION LIGHTFORM, INC. SVISION LLC LC SCIENCES LUMENERA CORPORATION VISITECH INTERNATIONAL Incubator, bacteriological NEW ENGLAND BIOLABS, INC. MBF BIOSCIENCE- BELLCO BIOTECHNOLOGY WORTHINGTON BIOCHEMICAL MICROBRIGHTFIELD Image analyzer, high speed CORPORATION MEDIA CYBERNETICS AVEGENE LIFE SCIENCE Incubators MOLECULAR DEVICES, NOW PART BD BIOSCIENCES 20/20 TECHNOLOGY, INC. OF MDS ANALYTICAL BITPLANE, INC. NUAIRE, INC. L TECHNOLOGIES CHROMODYNAMICS, INC. OKOLAB: LIVE CELL MICROSCOPY NIKON INSTRUMENTS INC. COOKE CORPORATION, THE SP INDUSTRIES Laboratory animals PHOTRON FUJIFILM LIFE SCIENCE, USA TOKAI HIT CO., LTD. COVANCE RESEARCH PRODUCTS SVISION LLC GE HEALTHCARE UVP, LLC THE OPEN MICROSCOPY MEDIA CYBERNETICS Laboratory apparatus, ENVIRONMENT MOLECULAR DEVICES, NOW PART Information services ADVANGENE CONSUMABLES, INC. TILL PHOTONICS LLC OF MDS ANALYTICAL ACTIVE MOTIF, INC. APPLIED BIOPHYSICS, INC. TECHNOLOGIES SELECTSCIENCE BIOMATRICA, INC. C TECHNOLOGIES, INC. Image analysis software PHOTRON SVISION LLC Inhibitors CELL KINETICS, LTD. AMG CELLASIC CORPORATION APPLIED PRECISION, LLC VISITECH INTERNATIONAL BIOMOL CAYMAN CHEMICAL COMPANY FINE SCIENCE TOOLS BD BIOSCIENCES NANOPOINT, INC. Image analyzer, ratiometric EMD CHEMICALS, INC. BITPLANE, INC. POINT SOURCE CHROMODYNAMICS, INC. PEPTIDES INTERNATIONAL CARL ZEISS MICROIMAGING, INC. SAKURA FINETEK USA INTELLIGENT IMAGING CHROMODYNAMICS, INC. SELECTSCIENCE INNOVATIONS Injectors COOKE CORPORATION, THE THORLABS DIAGNOSTIC INSTRUMENTS,INC. LEICA MICROSYSTEMS ALA SCIENTIFIC INSTRUMENTS HUYGENS SVI SVISION LLC INC. DRUMMOND SCIENTIFIC Laboratory furniture INTELLIGENT IMAGING NUAIRE, INC. INNOVATIONS Image intensifers EPPENDORF NORTH AMERICA LEICA MICROSYSTEMS COOKE CORPORATION, THE SUTTER INSTRUMENT COMPANY WARNER INSTRUMENTS Laboratory workstation, LI-COR BIOSCIENCES FAXITRON X-RAY LLC BIOMATRICA, INC. LUMENERA CORPORATION HAMAMATSU PHOTONICS, Insect cell media GE HEALTHCARE MBF BIOSCIENCE- SYSTEMS DIVISION GENETIX MICROBRIGHTFIELD PHOTRON BD BIOSCIENCES CLONTECH LABORATORIES, INC. INTELLICYT, INC. MEDIA CYBERNETICS SOLAMERE TECHNOLOGY GROUP, OMNI INTERNATIONAL: THE MOLECULAR DEVICES, NOW PART INC. Intensified cameras HOMOGENIZER COMPANY OF MDS ANALYTICAL STANFORD PHOTONICS INC. VIAFLO CORPORATION TECHNOLOGIES ANDOR TECHNOLOGY COOKE CORPORATION, THE NIKON INSTRUMENTS INC. Image processors Laminar flow equipment OKOLAB: Live Cell Microscopy DVC COMPANY BITPLANE, INC. HORIBA JOBIN YVON INC. NUAIRE, INC. OLYMPUS AMERICA INC. MBF BIOSCIENCE- PACIFIC NORTHWEST NATIONAL PHOTRON MICROBRIGHTFIELD STANFORD PHOTONICS INC. Laser scanning LABORATORY SVISION LLC FUJIFILM LIFE SCIENCE, USA PHOTRON Interference filters LEICA MICROSYSTEMS STANFORD PHOTONICS INC. Immunoassay system, CHROMA TECHNOLOGY LI-COR BIOSCIENCES SVISION LLC BD BIOSCIENCES CORPORATION VISITECH INTERNATIONAL THE OPEN MICROSCOPY CARL ZEISS MICROIMAGING, INC. CHROMODYNAMICS, INC. ENVIRONMENT CHROMODYNAMICS, INC. COOLLED LTD Lasers TILL PHOTONICS LLC CVI MELLES GRIOT Immunochemicals Internet services INTELLIGENT IMAGING Image analyzer ABD SEROTEC BIOCOMPARE INNOVATIONS BD BIOSCIENCES BETHYL LABORATORIES, INC. SELECTSCIENCE PHOTONIC INSTRUMENTS, INC. CHROMODYNAMICS, INC. BIOLYPH LLC WEALTH BUILDERS INVESTING POINT SOURCE GE HEALTHCARE BIOMOL SOLAMERE TECHNOLOGY GROUP, LEICA MICROSYSTEMS CELL SCIENCES, INC. Ion-Exchange resins INC. LI-COR BIOSCIENCES EPITOMICS, INC. CLONTECH LABORATORIES, INC. THORLABS MEDIA CYBERNETICS LAKE PLACID BIOLOGICALS VISITECH INTERNATIONAL MOLECULAR DEVICES, NOW PART LAMPIRE BIOLOGICAL Isolators OF MDS ANALYTICAL LABORATORIES, INC. ALA SCIENTIFIC INSTRUMENTS Lead shields TECHNOLOGIES INC. USA SCIENTIFIC INC. PHOTRON Immunohistochemistry NUAIRE, INC. SVISION LLC ABR—AFFINITY BIOREAGENTS Light boxes AMERICAN QUALEX ANTIBODIES Isotope-labeled POINT SOURCE Image analyzer, FISH SIGNAL TRANSDUCTION AMERICAN PEPTIDE COMPANY ANDOR TECHNOLOGY PRODUCTS Light scattering CHROMODYNAMICS, INC. BD BIOSCIENCES ACCURI CYTOMETERS, INC. GE HEALTHCARE BETHYL LABORATORIES, INC. J LEICA MICROSYSTEMS CAPRALOGICS, INC. Light sources MEDIA CYBERNETICS CEDARLANE LABORATORIES Job fairs CINCINNATI CHILDREN'S AMG MOLECULAR DEVICES, NOW PART CELL SIGNALING TECHNOLOGY® ASAHI SPECTRA USA INC. OF MDS ANALYTICAL CLONTECH LABORATORIES, INC. RESEARCH FOUNDATION ST. JUDE CHILDREN'S RESEARCH COOLLED LTD TECHNOLOGIES EPITOMICS, INC. INTELLIGENT IMAGING PHOTRON GE HEALTHCARE HOSPITAL THE SCIENTIST INNOVATIONS SVISION LLC GENWAY BIOTECH, INC. PHOTONIC INSTRUMENTS, INC. LAKE PLACID BIOLOGICALS PRIOR SCIENTIFIC, INC. Image analyzer, high LI-COR BIOSCIENCES K SUTTER INSTRUMENT COMPANY AVEGENE LIFE SCIENCE MITOSCIENCES, INC. THORLABS BD BIOSCIENCES NEWCOMER SUPPLY Kinases/phosphatases UVP, LLC CHROMODYNAMICS, INC. OLINK BIOSCIENCE 21st CENTURY BIOCHEMICALS, COOKE CORPORATION, THE R&D SYSTEMS, INC. INC. Lipids FUJIFILM LIFE SCIENCE, USA ABGENT, INC. A SLICE OF LIFE GE HEALTHCARE Immunological substances, ACTIVE MOTIF, INC. CAYMAN CHEMICAL COMPANY LEICA MICROSYSTEMS EPITOMICS, INC. BIOMOL ECHELON BIOSCIENCES LI-COR BIOSCIENCES GENWAY BIOTECH, INC. CELL BIOLABS, INC. MOLECULAR DEVICES, NOW PART CELL SIGNALING TECHNOLOGY® Liposome OF MDS ANALYTICAL Immunomodulators DISCOVERX CORPORATION A SLICE OF LIFE TECHNOLOGIES CELL SCIENCES, INC. INVITROGEN ECHELON BIOSCIENCES

214 The American Society for Cell Biology 47th Annual Meeting PRODUCT INDEX December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org

Liquid dispensers ASI/APPLIED SCIENTIFIC LAKE PLACID BIOLOGICALS INTELLIGENT IMAGING BRANDTECH SCIENTIFIC, INC. INSTRUMENTATION NEWCOMER SUPPLY INNOVATIONS GENETIX CELLASIC CORPORATION IONSCOPE LIMITED VIAFLO CORPORATION NANOPOINT, INC. Microscope slides, specialty LEICA MICROSYSTEMS OKOLAB: LIVE CELL MICROSCOPY CELL KINETICS, LTD. NIKON INSTRUMENTS INC. Liquid handling, automated PRECISION PLASTICS, INC. CELLASIC CORPORATION OLYMPUS AMERICA INC. BIOHIT, INC. TOKAI HIT CO., LTD. CHROMA TECHNOLOGY THORLABS EPPENDORF NORTH AMERICA CORPORATION VISITECH INTERNATIONAL GE HEALTHCARE Microbiological products NANOPOINT, INC. MICROBIOLOGY INTERNATIONAL AGAROSE BEAD TECHNOLOGIES THORLABS Microscopes, optical & MOLECULAR DEVICES, NOW PART BD BIOSCIENCES AMG OF MDS ANALYTICAL BTX/HARVARD APPARATUS Microscope, automated CHROMA TECHNOLOGY TECHNOLOGIES CELL KINETICS, LTD. µMANAGER CORPORATION OMNI INTERNATIONAL: THE CLONTECH LABORATORIES, INC. AMG COOLLED LTD HOMOGENIZER COMPANY APPLIED PRECISION, LLC DIAGNOSTIC INSTRUMENTS,INC. VIAFLO CORPORATION Microcarriers ASI/APPLIED SCIENTIFIC ELECTRON MICROSCOPY VISTALAB TECHNOLOGIES, INC. CELL KINETICS, LTD. INSTRUMENTATION SCIENCES/DIATOME U.S. GE HEALTHCARE JEOL USA, INC. EXFO LIFE SCIENCE & Luminescence imaging INAMED BIOMATERIALS LEICA MICROSYSTEMS INDUSTRIAL DIVISION ANDOR TECHNOLOGY LUDL ELECTRONIC PRODUCTS INTELLIGENT IMAGING APOGEE INSTRUMENTS, INC. Microdissecting LTD. INNOVATIONS COOKE CORPORATION, THE CARL ZEISS MICROIMAGING, INC. OBJECTIVE IMAGING LTD LEICA MICROSYSTEMS DVC COMPANY LEICA MICROSYSTEMS PRIOR SCIENTIFIC, INC. LUDL ELECTRONIC PRODUCTS FUJIFILM LIFE SCIENCE, USA LTD. GE HEALTHCARE Microforges Microscope, confocal NANONICS IMAGING LTD. LIGHTFORM, INC. ALA SCIENTIFIC INSTRUMENTS COOLLED LTD NIKON INSTRUMENTS INC. STANFORD PHOTONICS INC. INC. IONSCOPE LIMITED OLYMPUS AMERICA INC. ISS PHOTONIC INSTRUMENTS, INC. Luminometer Microinjector LEICA MICROSYSTEMS POINT SOURCE MOLECULAR DEVICES, NOW PART ASI/APPLIED SCIENTIFIC MOLECULAR DEVICES, NOW PART PRECISION PLASTICS, INC. OF MDS ANALYTICAL INSTRUMENTATION OF MDS ANALYTICAL SUTTER INSTRUMENT COMPANY TECHNOLOGIES BIOSCIENCE TOOLS TECHNOLOGIES THORLABS EPPENDORF NORTH AMERICA NANONICS IMAGING LTD. TOKAI HIT CO., LTD. Lymphokines SUTTER INSTRUMENT COMPANY NIKON INSTRUMENTS INC. CELL SCIENCES, INC. SOLAMERE TECHNOLOGY GROUP, Micromanipulators INC. Microscopes, scanning ALA SCIENTIFIC INSTRUMENTS THE OPEN MICROSCOPY FEI COMPANY M INC. ENVIRONMENT HITACHI HIGH TECHNOLOGIES AMERICA Magnetic particles ASI/APPLIED SCIENTIFIC THORLABS INSTRUMENTATION VISITECH INTERNATIONAL JEOL USA, INC. CLONTECH LABORATORIES, INC. NANONICS IMAGING LTD. COVALYS BIOSCIENCES AG DRUMMOND SCIENTIFIC MILTENYI BIOTEC, INC. EPPENDORF NORTH AMERICA Microscope, motorized FINE SCIENCE TOOLS APPLIED PRECISION, LLC Microscopes, scanning APPLIED PRECISION, LLC Magnetic particles LEICA MICROSYSTEMS ASI/APPLIED SCIENTIFIC ASYLUM RESEARCH ADVANGENE CONSUMABLES, INC. NIKON INSTRUMENTS INC. INSTRUMENTATION IONSCOPE LIMITED PROTEA BIOSCIENCES, INC. SUTTER INSTRUMENT COMPANY LEICA MICROSYSTEMS WARNER INSTRUMENTS LUDL ELECTRONIC PRODUCTS NANONICS IMAGING LTD. Magnetic stirrers LTD. VEECO INSTRUMENTS BEL-ART PRODUCTS Microorganisms NIKON INSTRUMENTS INC. CORNING INCORPORATED ATCC OBJECTIVE IMAGING LTD Microscopes, stereo SCIENTIFIC INDUSTRIES, INC. CLONTECH LABORATORIES, INC. PI (PHYSIK INSTRUMENTE) L.P. AMG RAINDANCE TECHNOLOGIES, INC. PRIOR SCIENTIFIC, INC. CARL ZEISS MICROIMAGING, INC. Mass spectral analysis LEICA MICROSYSTEMS 21st CENTURY BIOCHEMICALS, Microplate fluorometer Microscopes NIKON INSTRUMENTS INC. INC. BMG LABTECH, INC. µMANAGER OLYMPUS AMERICA INC. PRIMMBIOTECH, INC. HORIBA JOBIN YVON INC. A SLICE OF LIFE PRIOR SCIENTIFIC, INC. ISS AMG Mass spectrometers APPLIED PRECISION, LLC Microscopes, temperature GE HEALTHCARE Microplate readers FEI COMPANY 20/20 TECHNOLOGY, INC. BIOHIT, INC. HITACHI HIGH TECHNOLOGIES BIOSCIENCE TOOLS Meetings C TECHNOLOGIES, INC. AMERICA LEICA MICROSYSTEMS FASEB LI-COR BIOSCIENCES Ibidi LLC OKOLAB: LIVE CELL MICROSCOPY MARINE BIOLOGICAL MOLECULAR DEVICES, NOW PART INTELLIGENT IMAGING OF MDS ANALYTICAL INNOVATIONS LABORATORY (MBL) Microscopes, transmission TECHNOLOGIES IONSCOPE LIMITED THE AMERICAN ASSOCIATION OF A SLICE OF LIFE JEOL USA, INC. IMMUNOLOGISTS FEI COMPANY Microplate washers LEICA MICROSYSTEMS WEALTH BUILDERS INVESTING HITACHI HIGH TECHNOLOGIES MOLECULAR DEVICES, NOW PART MICROBIOLOGY INTERNATIONAL AMERICA OF MDS ANALYTICAL NIKON INSTRUMENTS INC. Membership JEOL USA, INC. AMERICAN SOCIETY FOR TECHNOLOGIES OLYMPUS AMERICA INC. INVESTIGATIVE PATHOLOGY PRIOR SCIENTIFIC, INC. THE AMERICAN ASSOCIATION OF Micropositioners THE OPEN MICROSCOPY Microscopy accessories, IMMUNOLOGISTS ALA SCIENTIFIC INSTRUMENTS ENVIRONMENT CELLASIC CORPORATION WEALTH BUILDERS INVESTING INC. THORLABS CHROMA TECHNOLOGY ASI/APPLIED SCIENTIFIC TILL PHOTONICS LLC CORPORATION Membrane Filters INSTRUMENTATION VEECO INSTRUMENTS ELECTRON MICROSCOPY GE HEALTHCARE FINE SCIENCE TOOLS SCIENCES/DIATOME U.S. MILLIPORE PI (PHYSIK INSTRUMENTE) L.P. Microscopes, atomic force EXFO LIFE SCIENCE & SUTTER INSTRUMENT COMPANY ASYLUM RESEARCH INDUSTRIAL DIVISION Micro, glassware THORLABS IONSCOPE LIMITED Ibidi LLC DRUMMOND SCIENTIFIC JEOL USA, INC. LEICA MICROSYSTEMS NANOPOINT, INC. Microscope slide filing NANONICS IMAGING LTD. MAG BIOSYSTEMS SUTTER INSTRUMENT COMPANY SAKURA FINETEK USA VEECO INSTRUMENTS SEMROCK, INC. THORLABS Micro, incubators Microscope slides Microscopes, confocal TOUSIMIS 20/20 TECHNOLOGY, INC. ELECTRON MICROSCOPY A SLICE OF LIFE ALA SCIENTIFIC INSTRUMENTS SCIENCES/DIATOME U.S. APPLIED PRECISION, LLC Microtome knife sharpeners INC. Ibidi LLC CARL ZEISS MICROIMAGING, INC. LEICA MICROSYSTEMS

215 PRODUCT INDEX The American Society for Cell Biology 47th Annual Meeting December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org

Microtome knives PRIMMBIOTECH, INC. SELECTSCIENCE PEPTIDES INTERNATIONAL BOECKELER INSTRUMENTS, INC. PROTEINTECH GROUP, INC. WEALTH BUILDERS INVESTING TOCRIS BIOSCIENCE ELECTRON MICROSCOPY SCIENCES/DIATOME U.S. Monoclonal antibodies, Optical filters Perfusion system LEICA MICROSYSTEMS EPITOMICS, INC. CHROMA TECHNOLOGY ALA SCIENTIFIC INSTRUMENTS SAKURA FINETEK USA FIBERCELL SYSTEMS, INC. CORPORATION INC. GE HEALTHCARE COOLLED LTD BIOSCIENCE TOOLS Microtomes GENOVAC GMBH CVI MELLES GRIOT OKOLAB: LIVE CELL MICROSCOPY BOECKELER INSTRUMENTS, INC. LEICA MICROSYSTEMS WARNER INSTRUMENTS LEICA MICROSYSTEMS Monoclonal typing kits OMEGA OPTICAL, INC. SAKURA FINETEK USA ABD SEROTEC SEMROCK, INC. Peroxidase conjugated CELL SCIENCES, INC. SOLAMERE TECHNOLOGY GROUP, BETHYL LABORATORIES, INC. Microtomes, ultra INC. EPITOMICS, INC. ELECTRON MICROSCOPY Morpholinos THORLABS JACKSON IMMUNORESEARCH SCIENCES/DIATOME U.S. GENE TOOLS, LLC LABORATORIES, INC. LEICA MICROSYSTEMS Optical interference filters MRNA purification kits COOLLED LTD Petri dishes Microtomes, vibrating BIOMATRICA, INC. LEICA MICROSYSTEMS BD BIOSCIENCES ELECTRON MICROSCOPY MILTENYI BIOTEC, INC. OMEGA OPTICAL, INC. GREINER BIO-ONE SCIENCES/DIATOME U.S. SYSTEM BIOSCIENCES (SBI) THORLABS NANOPOINT, INC. LEICA MICROSYSTEMS WEALTH BUILDERS INVESTING SARSTEDT, INC. Organic laboratory USA SCIENTIFIC INC. Mixers Mycoplasma detection RESEARCH ORGANICS, INC. WARNER INSTRUMENTS EPPENDORF NORTH AMERICA CAMBREX RESEARCH PRODUCTS PRO SCIENTIFIC INC. (NOW LONZA) Ovens Pharmaceutical QORPAK CORIELL CELL REPOSITORIES ELECTRON MICROSCOPY C TECHNOLOGIES, INC. SARSTEDT, INC. LONZA (FORMERLY CAMBREX SCIENCES/DIATOME U.S. SCIENTIFIC INDUSTRIES, INC. RESEARCH PRODUCTS) THORLABS Phosphor imager PROMOCELL GMBH FUJIFILM LIFE SCIENCE, USA Molecular biology reagents ROCHE APPLIED SCIENCE ABR—AFFINITY BIOREAGENTS P Photographic equipment, AGAROSE BEAD TECHNOLOGIES N DVC COMPANY B-BRIDGE INTERNATIONAL, INC. Particle counters PHOTRON CAMBREX RESEARCH PRODUCTS ACCURI CYTOMETERS, INC. (NOW LONZA) Nearfield scanning optical Photographic products NANONICS IMAGING LTD. CEDARLANE LABORATORIES PCR kits PHOTRON CELL SCIENCES, INC. CLONTECH LABORATORIES, INC. EVROGEN Neurochemicals Photometers BIOMOL EDVOTEK, INC. GENECOPOEIA, INC. GE HEALTHCARE TILL PHOTONICS LLC LONZA (FORMERLY CAMBREX CELL SCIENCES, INC. TOCRIS BIOSCIENCE HIGH THROUGHPUT GENOMICS RESEARCH PRODUCTS) NEW ENGLAND BIOLABS, INC. Phycoexythrim conjugated MILTENYI BIOTEC, INC. JACKSON IMMUNORESEARCH Neutrotoxins ROCHE APPLIED SCIENCE MIRUS BIO CORPORATION LABORATORIES, INC. CELL SCIENCES, INC. SYSTEM BIOSCIENCES (SBI) NORGEN BIOTEK CORPORATION TAKARA BIO USA RESEARCH ORGANICS, INC. Pipette pullers Nitric oxide reagents USB CORPORATION ROCHE APPLIED SCIENCE ALA SCIENTIFIC INSTRUMENTS BIOMOL SYSTEM BIOSCIENCES (SBI) INC. CAYMAN CHEMICAL COMPANY PCR purification kit BEL-ART PRODUCTS TEL-TEST, INC. AVEGENE LIFE SCIENCE SUTTER INSTRUMENT COMPANY WEALTH BUILDERS INVESTING Nucleic acid derivatives CLONTECH LABORATORIES, INC. WARNER INSTRUMENTS WORTHINGTON BIOCHEMICAL CLONTECH LABORATORIES, INC. MO BIO LABORATORIES CORPORATION GLEN RESEARCH CORPORATION NORGEN BIOTEK CORPORATION Pipettes SYSTEM BIOSCIENCES (SBI) Molecular biology software BD BIOSCIENCES Nucleic acid isolations TAKARA BIO USA BIOMATRICA, INC. BEL-ART PRODUCTS AVEGENE LIFE SCIENCE ZYMO RESEARCH CORPORATION BIOHIT, INC. DNASTAR, INC. CLONTECH LABORATORIES, INC. CORNING INCORPORATED CORIELL CELL REPOSITORIES Monitors PCR reagents EPPENDORF NORTH AMERICA PROMEGA CORPORATION ASI/APPLIED SCIENTIFIC CLONTECH LABORATORIES, INC. GREINER BIO-ONE ZYMO RESEARCH CORPORATION INSTRUMENTATION FINNZYMES NANONICS IMAGING LTD. YSI, INC. NEW ENGLAND BIOLABS, INC. RAININ INSTRUMENT, LLC Nucleic acid sequence ROCHE APPLIED SCIENCE SARSTEDT, INC. DNASTAR, INC. Monochromators SYSTEM BIOSCIENCES (SBI) USA SCIENTIFIC INC. THORLABS USB CORPORATION Nucleotides VIAFLO CORPORATION BIOMATRICA, INC. WARNER INSTRUMENTS Monoclonal antibodies Peptide synthesis GLEN RESEARCH CORPORATION 21st CENTURY BIOCHEMICALS, C S BIO INC. Pipettes, automatic NEW ENGLAND BIOLABS, INC. INC. PEPTIDES INTERNATIONAL AVEGENE LIFE SCIENCE ROCHE APPLIED SCIENCE ABD SEROTEC BD BIOSCIENCES USB CORPORATION ABGENT, INC. Peptide synthesizer BEL-ART PRODUCTS ABR—AFFINITY BIOREAGENTS C S BIO INC. DRUMMOND SCIENTIFIC BD BIOSCIENCES O RAININ INSTRUMENT, LLC BIOHIT, INC. Peptides, pharmaceutical USA SCIENTIFIC INC. BIOLEGEND, INC. Oligonucleotide AMERICAN PEPTIDE COMPANY VIAFLO CORPORATION BIOMOL GLEN RESEARCH CORPORATION C S BIO INC. VISTALAB TECHNOLOGIES, INC. CEDARLANE LABORATORIES CELL SCIENCES, INC. CELL SCIENCES, INC. Oligonucleotide synthesizer PRIMMBIOTECH, INC. Pipettes, automatic, hand CELL SIGNALING TECHNOLOGY® GE HEALTHCARE BEL-ART PRODUCTS COVANCE RESEARCH PRODUCTS Peptides, synthetic BIOHIT, INC. EPITOMICS, INC. Oligonucleotides 21st CENTURY BIOCHEMICALS, RAININ INSTRUMENT, LLC GENETIX BIOMATRICA, INC. INC. VIAFLO CORPORATION GENOVAC GMBH GE HEALTHCARE ABGENT, INC. WHEATON SCIENCE PRODUCTS LAKE PLACID BIOLOGICALS GENE TOOLS, LLC ABR—AFFINITY BIOREAGENTS LAMPIRE BIOLOGICAL LC SCIENCES AMERICAN PEPTIDE COMPANY Pipettes, automatic, motor LABORATORIES, INC. LI-COR BIOSCIENCES BIOMOL BIOHIT, INC. MILTENYI BIOTEC, INC. C S BIO INC. BRANDTECH SCIENTIFIC, INC. MITOSCIENCES, INC. On-line services GENOVAC GMBH DRUMMOND SCIENTIFIC NEWCOMER SUPPLY BIOCOMPARE LC SCIENCES RAININ INSTRUMENT, LLC PEPROTECH, INC. PROQUEST PEPROTECH, INC. VIAFLO CORPORATION

216 The American Society for Cell Biology 47th Annual Meeting PRODUCT INDEX December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org

Pipettes, micro KINEXUS BIOINFORMATICS Radioactive products WASHINGTON UNIVERSITY IN ST. AVEGENE LIFE SCIENCE CORPORATION GE HEALTHCARE LOUIS, OFFICE OF POST BEL-ART PRODUCTS LC SCIENCES TEL-TEST, INC. GRADUATE AFFAIRS BIOHIT, INC. RAINDANCE TECHNOLOGIES, INC. BRANDTECH SCIENTIFIC, INC. Radiochemicals Research funding EPPENDORF NORTH AMERICA Protein purification system GE HEALTHCARE AMERICAN FRIENDS OF THE RAININ INSTRUMENT, LLC A SLICE OF LIFE TEL-TEST, INC. ALEXANDER VON HUMBOLDT USA SCIENTIFIC INC. ADVANGENE CONSUMABLES, INC. FOUNDATION VIAFLO CORPORATION AGAROSE BEAD TECHNOLOGIES Radioisotope labeled NATIONAL INSTITUTE OF CHILD VISTALAB TECHNOLOGIES, INC. B-BRIDGE INTERNATIONAL, INC. TEL-TEST, INC. HEALTH AND HUMAN C TECHNOLOGIES, INC. DEVELOPMENT (NICHD) Plasma COVALYS BIOSCIENCES AG Radioisotopes NATIONAL SCIENCE FOUNDATION BIOMATRICA, INC. EMD Chemicals, Inc. TEL-TEST, INC. NIH STEM CELL INFORMATION CAPRALOGICS, INC. GE HEALTHCARE NIH, NATIONAL EYE INSTITUTE LAMPIRE BIOLOGICAL GENWAY BIOTECH, INC. Reagent, dog LABORATORIES, INC. LIFESENSORS, INC. BD BIOSCIENCES Restriction enzymes MILLIPORE CELL SCIENCES, INC. NEW ENGLAND BIOLABS, INC. Plastic laboratory ware PROMEGA CORPORATION TAKARA BIO USA ADVANGENE CONSUMABLES, INC. PROTEOPURE, INC. Reagent, rat BD BIOSCIENCES BD BIOSCIENCES RNA isolation BIOMATRICA, INC. Protein sequence analysis BIOLEGEND, INC. APPLIED BIOSYSTEMS BRANDTECH SCIENTIFIC, INC. DNASTAR, INC. CELL SCIENCES, INC. AVEGENE LIFE SCIENCE CORNING INCORPORATED PACIFIC NORTHWEST NATIONAL PEPROTECH, INC. B-BRIDGE INTERNATIONAL, INC. SARSTEDT, INC. LABORATORY BIOMATRICA, INC. USA SCIENTIFIC INC. Reagents CORIELL CELL REPOSITORIES WHEATON SCIENCE PRODUCTS Protein structure analysis ABGENT, INC. GE HEALTHCARE C TECHNOLOGIES, INC. ABR—AFFINITY BIOREAGENTS MO BIO LABORATORIES Power supplies APPLIED BIOSYSTEMS NORGEN BIOTEK CORPORATION GE HEALTHCARE Pump fluid, synthetic BD BIOSCIENCES ROCHE APPLIED SCIENCE LUDL ELECTRONIC PRODUCTS HARVARD APPARATUS BIOLYPH LLC SYSTEM BIOSCIENCES (SBI) LTD. BIOMOL TEL-TEST, INC. Pumps CAPRALOGICS, INC. ZYMO RESEARCH CORPORATION Professional society CELLASIC CORPORATION CEDARLANE LABORATORIES ACS PUBLICATIONS HARVARD APPARATUS COVALYS BIOSCIENCES AG Robotic coverslippers VIAFLO CORPORATION DISCOVERX CORPORATION SAKURA FINETEK USA GE HEALTHCARE Protein binding studies LI-COR BIOSCIENCES ACTIVE MOTIF, INC. Pumps, gradient for liquid Robotic slide handler MIRUS BIO CORPORATION COVALYS BIOSCIENCES AG HARVARD APPARATUS LUDL ELECTRONIC PRODUCTS MOLECULAR DEVICES, NOW PART CYTOSKELETON, INC. LTD. OF MDS ANALYTICAL DISCOVERX CORPORATION Pumps, peristaltic TECHNOLOGIES HARVARD APPARATUS SAMPLE BIOSCIENCE TOOLS Robotics NEWCOMER SUPPLY PREP HARVARD APPARATUS INTELLICYT, INC. OLINK BIOSCIENCE OLINK BIOSCIENCE RAININ INSTRUMENT, LLC LATHROP ENGINEERING INC PEPROTECH, INC. Pumps, vacuum PEPTIDES INTERNATIONAL Rocker platforms Protein blotting PROMEGA CORPORATION CELL BIOLABS, INC. BRANDTECH SCIENTIFIC, INC. BELLCO BIOTECHNOLOGY PROTEA BIOSCIENCES, INC. SCIENTIFIC INDUSTRIES, INC. CLONTECH LABORATORIES, INC. R&D SYSTEMS, INC. DISCOVERX CORPORATION Purification of antibodies STOVALL LIFE SCIENCE, INC. AGAROSE BEAD TECHNOLOGIES RESEARCH ORGANICS, INC. GE HEALTHCARE SAKURA FINETEK USA LI-COR BIOSCIENCES CLONTECH LABORATORIES, INC. Rotors COVANCE RESEARCH PRODUCTS SYSTEM BIOSCIENCES (SBI) SCIENTIFIC INDUSTRIES, INC. MILLIPORE TAKARA BIO USA NANOPROBES, INC. GE HEALTHCARE GENOVAC GMBH TEL-TEST, INC. PRIMMBIOTECH, INC. USB CORPORATION S Protein concentration ZEN-BIO, INC. C TECHNOLOGIES, INC. Safety shields Purification-large scale CLONTECH LABORATORIES, INC. Reagents, mouse BEL-ART PRODUCTS AMERICAN PEPTIDE COMPANY HARVARD APPARATUS SAMPLE BD BIOSCIENCES USA SCIENTIFIC INC. GE HEALTHCARE PREP BIOLEGEND, INC. NORGEN BIOTEK CORPORATION MILLIPORE CELL SCIENCES, INC. Sample preparation, WORTHINGTON BIOCHEMICAL NORGEN BIOTEK CORPORATION PEPROTECH, INC. ARCXIS BIOTECHNOLOGIES CORPORATION POLYPLUS-TRANSFECTION BIOMATRICA, INC. Protein databases BOECKELER INSTRUMENTS, INC. KINEXUS BIOINFORMATICS Purified proteins Recruiting C TECHNOLOGIES, INC. CORPORATION ABR—AFFINITY BIOREAGENTS NATIONAL INSTITUTE OF ALLERGY GE HEALTHCARE BD BIOSCIENCES AND INFECTIOUS DISEASES GENVAULT CORPORATION Protein expression BIOMOL NATIONAL INSTITUTE OF CHILD HARVARD APPARATUS SAMPLE BTX/HARVARD APPARATUS CLONTECH LABORATORIES, INC. HEALTH AND HUMAN PREP CLONTECH LABORATORIES, INC. CYTOSKELETON, INC. DEVELOPMENT (NICHD) LEICA MICROSYSTEMS EMD Chemicals, Inc. GE HEALTHCARE SELECTSCIENCE MOLECULAR DEVICES, NOW PART FIBERCELL SYSTEMS, INC. WORTHINGTON BIOCHEMICAL OF MDS ANALYTICAL GE HEALTHCARE CORPORATION Refrigerators TECHNOLOGIES GENECOPOEIA, INC. SCIENTIFIC INDUSTRIES, INC. TOUSIMIS GENETIX Q VIAFLO CORPORATION GENWAY BIOTECH, INC. Research awards- LIFESENSORS, INC. Quantitation kits CINCINNATI CHILDREN'S Scanners, gel PRIMMBIOTECH, INC. BD BIOSCIENCES RESEARCH FOUNDATION LI-COR BIOSCIENCES PROMEGA CORPORATION CLONTECH LABORATORIES, INC. NATIONAL INSTITUTE OF CHILD ROCHE APPLIED SCIENCE GE HEALTHCARE HEALTH AND HUMAN Scientific information QUANSYS BIOSCIENCES DEVELOPMENT (NICHD) SELECTSCIENCE Protein free media SYSTEM BIOSCIENCES (SBI) NATIONAL INSTITUTE OF HEALTH, TITIAN SOFTWARE PROMOCELL GMBH OFFICE OF INTRAMURAL TRAINING AND EDUCATION Scientific software Protein kinase assay kit R NATIONAL RESEARCH COUNCIL µMANAGER ACTIVE MOTIF, INC. OF THE NATIONAL BIOMATRICA, INC. BIOMOL Radiation detectors ACADEMIES BIOTRUE INC. CELL BIOLABS, INC. BEL-ART PRODUCTS ST. JUDE CHILDREN'S RESEARCH BITPLANE, INC. CELL SIGNALING TECHNOLOGY® STANFORD PHOTONICS INC. HOSPITAL DATAWORKS DEVELOPMENT, INC.

217 PRODUCT INDEX The American Society for Cell Biology 47th Annual Meeting December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org

DNASTAR, INC. MBF BIOSCIENCE- T Tissue embedding media MBF BIOSCIENCE- MICROBRIGHTFIELD SAKURA FINETEK USA MICROBRIGHTFIELD MEDIA CYBERNETICS Teflon laboratory products MEDIA CYBERNETICS NANOPOINT, INC. FINE SCIENCE TOOLS Tissue fixatives SOLAMERE TECHNOLOGY GROUP, SVISION LLC NEWCOMER SUPPLY INC. THOMSON RESEARCHSOFT Temperature controllers SAKURA FINETEK USA TITIAN SOFTWARE TITIAN SOFTWARE 20/20 TECHNOLOGY, INC. ALA SCIENTIFIC INSTRUMENTS Tissue grinders Sequence analyzer Spectral bio-imaging INC. BEL-ART PRODUCTS GE HEALTHCARE CHROMODYNAMICS, INC. BIOSCIENCE TOOLS WHEATON SCIENCE PRODUCTS RAINDANCE TECHNOLOGIES, INC. DVC COMPANY FINE SCIENCE TOOLS LIGHTFORM, INC. SP INDUSTRIES Tissue processors Sequencing reagents TOKAI HIT CO., LTD. BOECKELER INSTRUMENTS, INC. GE HEALTHCARE Spectrofluorometers WARNER INSTRUMENTS ELECTRON MICROSCOPY HORIBA JOBIN YVON INC. SCIENCES/DIATOME U.S. Serum substitutes ISS Temperature probes LEICA MICROSYSTEMS MEDIATECH, INC. LIGHTFORM, INC. FINE SCIENCE TOOLS SAKURA FINETEK USA PAA LABORATORIES, INC., USA MOLECULAR DEVICES, NOW PART OF MDS ANALYTICAL Test equipment, Tissue sectioners Serum-free media TECHNOLOGIES PI (PHYSIK INSTRUMENTE) L.P. ELECTRON MICROSCOPY CAMBREX RESEARCH PRODUCTS NANODROP TECHNOLOGIES, INC. SCIENCES/DIATOME U.S. (NOW LONZA) Test tube racks INVITROGEN Spectrometers BEL-ART PRODUCTS Transfection kits LIFELINE CELL TECHNOLOGY HAMAMATSU PHOTONICS, ACTIVE MOTIF, INC. LONZA (FORMERLY CAMBREX SYSTEMS DIVISION Thermal cycler AMAXA AG RESEARCH PRODUCTS) HORIBA JOBIN YVON INC. APPLIED BIOSYSTEMS B-BRIDGE INTERNATIONAL, INC. MEDIATECH, INC. LIGHTFORM, INC. EDVOTEK, INC. BIOMATRICA, INC. PAA LABORATORIES, INC., USA MOLECULAR DEVICES, NOW PART EPPENDORF NORTH AMERICA CAMBREX RESEARCH PRODUCTS PROMOCELL GMBH OF MDS ANALYTICAL FINNZYMES (NOW LONZA) TECHNOLOGIES ROCHE APPLIED SCIENCE CLONTECH LABORATORIES, INC. Serums DIGITAL BIO ATCC Spectrophotometer cells Tissue culture apparatus LONZA (FORMERLY CAMBREX CAMBREX RESEARCH PRODUCTS BRANDTECH SCIENTIFIC, INC. APPLIED BIOPHYSICS, INC. RESEARCH PRODUCTS) (NOW LONZA) FIBERCELL SYSTEMS, INC. MIRUS BIO CORPORATION CAPRALOGICS, INC. Spectrophotometer light FLEXCELL INTERNATIONAL PAA LABORATORIES, INC., USA JACKSON IMMUNORESEARCH HORIBA JOBIN YVON INC. CORPORATION POLYPLUS-TRANSFECTION LABORATORIES, INC. WARNER INSTRUMENTS PROMOCELL GMBH LAMPIRE BIOLOGICAL Spectrophotometer, micro ROCHE APPLIED SCIENCE LABORATORIES, INC. LIGHTFORM, INC. Tissue culture CO2 SYSTEM BIOSCIENCES (SBI) LONZA (FORMERLY CAMBREX NANODROP TECHNOLOGIES, INC. OKOLAB: LIVE CELL MICROSCOPY RESEARCH PRODUCTS) TOKAI HIT CO., LTD. Tubing connectors and MEDIATECH, INC. Spectrophotometers WARNER INSTRUMENTS PAA LABORATORIES, INC., USA C TECHNOLOGIES, INC. Tissue culture hood PROMOCELL GMBH GE HEALTHCARE PRECISION PLASTICS, INC. Tumor markers HAMAMATSU PHOTONICS, ABD SEROTEC Shakers SYSTEMS DIVISION Tissue culture inserts LI-COR BIOSCIENCES BEL-ART PRODUCTS LIGHTFORM, INC. BD BIOSCIENCES PRO SCIENTIFIC INC. MOLECULAR DEVICES, NOW PART CORNING INCORPORATED Tyrosine kinase inhibitors QORPAK OF MDS ANALYTICAL GLYCOSAN BIOSYSTEMS, INC. BIOMOL SARSTEDT, INC. TECHNOLOGIES GREINER BIO-ONE CELL SCIENCES, INC. SCIENTIFIC INDUSTRIES, INC. NANODROP TECHNOLOGIES, INC. MILLIPORE CELL SIGNALING TECHNOLOGY® STOVALL LIFE SCIENCE, INC. USA SCIENTIFIC INC. Spin columns Tissue culture labware AGAROSE BEAD TECHNOLOGIES ADVANGENE CONSUMABLES, INC. U Signal transduction CLONTECH LABORATORIES, INC. APPLIED BIOPHYSICS, INC. 21st CENTURY BIOCHEMICALS, GE HEALTHCARE CORNING INCORPORATED Ultrasonic cell disintegrator INC. MO BIO LABORATORIES FIBERCELL SYSTEMS, INC. OMNI INTERNATIONAL: THE ABGENT, INC. NORGEN BIOTEK CORPORATION GREINER BIO-ONE HOMOGENIZER COMPANY ABR—AFFINITY BIOREAGENTS ROCHE APPLIED SCIENCE SARSTEDT, INC. BD BIOSCIENCES USA SCIENTIFIC INC. UV crosslinks BIOLEGEND, INC. Spinner flasks UVP, LLC BIOMOL CORNING INCORPORATED Tissue culture media CELL BIOLABS, INC. SCIENTIFIC INDUSTRIES, INC. CAMBREX RESEARCH PRODUCTS UV fluorescence CELL SCIENCES, INC. WHEATON SCIENCE PRODUCTS (NOW LONZA) AVEGENE LIFE SCIENCE CELL SIGNALING TECHNOLOGY® LONZA (FORMERLY CAMBREX CYTOSKELETON, INC. Statistics software RESEARCH PRODUCTS) UV Transillumenators SYSTEM BIOSCIENCES (SBI) BITPLANE, INC. PAA LABORATORIES, INC., USA AVEGENE LIFE SCIENCE TOCRIS BIOSCIENCE RESEARCH ORGANICS, INC. USA SCIENTIFIC INC. Stepper (motor) UVP, LLC Slide, drying chamber SUTTER INSTRUMENT COMPANY Tissue culture media bags BIOMATRICA, INC. PAA LABORATORIES, INC., USA Sterilizer, agar V Slide, stainers MICROBIOLOGY INTERNATIONAL Tissue culture sera, human LEICA MICROSYSTEMS PAA LABORATORIES, INC., USA Vacuum coating equipment Sterilizers BOECKELER INSTRUMENTS, INC. Software UVP, LLC Tissue cultures µMANAGER BD BIOSCIENCES Vacuum concentration ANDOR TECHNOLOGY Sterotaxics BIOLOGIX RESEARCH COMPANY SP INDUSTRIES BIOMATRICA, INC. FINE SCIENCE TOOLS GLYCOSAN BIOSYSTEMS, INC. BIOTRUE INC. Vacuum system accessories BITPLANE, INC. Stirrers Tissue dissociation enzymes BRANDTECH SCIENTIFIC, INC. DATAWORKS DEVELOPMENT, INC. BEL-ART PRODUCTS ROCHE APPLIED SCIENCE DNASTAR, INC. BELLCO BIOTECHNOLOGY WORTHINGTON BIOCHEMICAL Vectors HUYGENS SVI PRO SCIENTIFIC INC. CORPORATION AMAXA AG INTELLICYT, INC. SCIENTIFIC INDUSTRIES, INC. COVALYS BIOSCIENCES AG INTELLIGENT IMAGING Tissue embedding LIFESENSORS, INC. INNOVATIONS Surgical instruments LEICA MICROSYSTEMS PROMEGA CORPORATION LUMENERA CORPORATION FINE SCIENCE TOOLS SAKURA FINETEK USA SYSTEM BIOSCIENCES (SBI)

218 The American Society for Cell Biology 47th Annual Meeting PRODUCT INDEX December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org

Vibration isolation ALA SCIENTIFIC INSTRUMENTS INC. CVI MELLES GRIOT THORLABS

Video microscopy systems AMG ASI/APPLIED SCIENTIFIC INSTRUMENTATION DVC COMPANY HAMAMATSU PHOTONICS, SYSTEMS DIVISION LUMENERA CORPORATION MBF BIOSCIENCE- MICROBRIGHTFIELD OKOLAB: Live Cell Microscopy SVISION LLC THORLABS

Video systems measuring MBF BIOSCIENCE- MICROBRIGHTFIELD SVISION LLC

Viral reagents CELL BIOLABS, INC. CELL SCIENCES, INC. CLONTECH LABORATORIES, INC. SYSTEM BIOSCIENCES (SBI)

Viruses CELL BIOLABS, INC. CELL SCIENCES, INC. CLONTECH LABORATORIES, INC. SYSTEM BIOSCIENCES (SBI)

Visual research equipment THORLABS

W Water bath shakers STOVALL LIFE SCIENCE, INC.

Water baths BEL-ART PRODUCTS EDVOTEK, INC. LEICA MICROSYSTEMS STOVALL LIFE SCIENCE, INC.

Western blotting equipment CLONTECH LABORATORIES, INC. FUJIFILM LIFE SCIENCE, USA GE HEALTHCARE LI-COR BIOSCIENCES STOVALL LIFE SCIENCE, INC.

219 PRODUCT INDEX The American Society for Cell Biology 47th Annual Meeting December 1–5, 2007  Washington, DC  [email protected]  www.ascb.org

NOTES

220 The American Society for Cell Biology 47th Annual Meeting AUTHOR INDEX December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org AUTHOR INDEX Numbers refer to abstracts

Akiyoshi, Bungo ...... 1497 Amsler, Kurt ...... 1786 A Aksan-Kurnaz, I ıl ...... 2299 An, Hyun-Jung ...... 1561 Aakre, Chris ...... 28 Akutagawa, Jon ...... 1358 An, Jahyun ...... 1298 Abbott, Nick ...... 1413A Akutsu, Yasunori ...... 1362 An, Seong J...... 2402 Abdalla, Moemen ...... 1921, 1922 Akutsu-Yamauchi, Hitomi ...... 69, 79 An, Xiuli ....280, 348, 349, 350, 594, 595, 1162, 1787 Abdi, Khadar M...... 998 Akyuz, Fatih ...... 1227 Anastasiadis, Panos Z...... 368, 895, 902, 1870 Abe, Hideharu ...... 524 Al Awabdh, Sana ...... 777 Andersen, Claus Y...... 450 Abe, Ken ...... 617 Al-Bassam, Jawdat ...... 751 Andersen, Tim L...... 1216 Abe, Mitsuhiro ...... 653 Al-Haboubi, Teiba ...... 1255 Anderson, Amanda ...... 342 Abe, Yohei ...... 1341 Alaei, Sarah ...... 1124 Anderson, Andrea M...... 1965 Abele, J. Abele ...... 1741 Alaggio, Rita ...... 2196 Anderson, Alexander R. A...... 308 Abidi, Parveen ...... 1221 Alarcon, Lourdes ...... 865 Anderson, David A...... 538 Ablin, Richard J...... 877 Albarrán-Bravo, Sacnité ...... 1294 Anderson, Deborah H. ...857, 2189, 2190, 2191, 2192 Abou-Kheir, Wassim ...... 22, 436 Albee, Alison J...... 1437 Anderson, Daniel J...... 1258 Abraham, Christian ...... 2362 Alber, Frank ...... 1626 Anderson, Garrett ...... 630 Abraham, David ...... 318, 1820 Albers, Wayne ...... 2350 Anderson, Kathryn V...... 793 Abrieu, Ariane ...... 2241 Alberts, Jonathan B...... 755, 849 Anderson, Robert L...... 731 Acevedo Mendez, Sujeil ...... 647 Albrecht, Eric ...... 141 Anderson, Sheila A...... 516 Acker, Karen ...... 1741 Alcaraz, Jordi ...... 1230 Anderson, Trevor E...... 272 Acosta, Perez ...... 535 Aldred, Sandi ...... 2034 Andhare, Roma A...... 1579 Acousta, Pedro ...... 1389 Aleman, Jose O...... 505 Ando, Kentaro ...... 899 Adam, Stephen A...... 841 Alexander, Nelson R...... 308 Ando, Yukio ...... 1379 Adams, J...... 1180 Alexander, Todd ...... 302 Andres-Hernando, Ana ...... 1128, 1966 Adams, Josephine C...... 1795 Alford, Lea M...... 1044 Andrew, Deborah J...... 1010 Adams, Matthew ...... 460 Alford, William B...... 2434 Andrews, Brenda ...... 1078 Adamson, Saudat ...... 1349 Allada, Ravi ...... 1594 Andrews, David W...... 371, 806, 1078 Adang, Laura A...... 937 Allaire, Patrick D...... 1092 Andrews, Michael P...... 463 Adelstein, Robert S...... 2304, 2305, 2307, Allan, Chris ...... 1496 Andrews, Norma W...... 273 2308, 2309, 2310, 2352 Allan, Victoria J...... 1727 Andrieux, Annie ...... 2301, 2330 Adhikari, Sean ...... 212 Allen, Emily ...... 1372 Androutsellis-Theotokis, Andreas ...... 237 Adib, Abdennaji ...... 1200 Allen, Greg M...... 1638, 2277 Angers, Stephane ...... 1481 Adjerid, Nassiba ...... 2148 Allen, Jessica ...... 1511 Anglin, Ian E...... 2273 Adler, Lesli ...... 1741 Allen, John A...... 2435 Angres, Brigitte M...... 1191 Adyshev, Djanybek ...... 1834 Alli, Abdel A...... 290 Angsuthanasombat, Chanan ...... 1330 Aebi, Ueli ...... 35, 842, 1255, 2339, 2345, 2358 Alli, Nezeka ...... 2035 Anikeeva, Nadia ...... 892 Afshar, Katayoun ...... 1519 Allison, Lizabeth A...... 1854, 1963, 1964 Ann, Eun-Jung ...... 1568, 1569, 1570, 1889 Agar, Stacy L...... 549 Almeida, Nestor E...... 1128, 1966 Annas-Linhares, Yuliya ...... 1902 Agarwal, Payal ...... 1534 Almo, Steven C...... 1485 Anne, Sandrine L...... 1509 Agassandian, Marianna ...... 1967 Alonso, Juan C...... 119 Annis, Douglas S...... 77, 338, 2399 Agee, Joy ...... 1148 Alonso-Latorre, Baldomero ...... 419 Antar, Laura ...... 1263 Aghajanian, Amir ...... 1414 Alsaraby, Ayat ...... 2341 Antoch, Marina ...... 1599 Agronskaia, Alexandra V...... 1935 Altan-Bonnet, Nihal ...... 540, 1210, 2427 Antonetti, Dave A...... 100 Aguiar, Alessandra ...... 1182 Altenberg, Guillermo A...... 1125, 1143 Antoniewicz, Maciek ...... 505 Aguilar, Ruben C...... 655, 1103 Altimare, Domenico ...... 1981 Antonioli, Eliane ...... 319 Aguilera, Renato, J...... 685, 1989 Altinok, Alphan ...... 1449, 1463 Antony, Claude ...... 750, 941 Aguirre, Adan ...... 782 Alvares, Eliana P...... 71 Antrobus, Philip R...... 748 Ahmad, Kashif A...... 1355 Alvarez, Michael ...... 1546 Ao, Wei ...... 1767 Ahmad, Rili ...... 1381 Alves, Annabelle ...... 1547 Aoki, Hiroki ...... 514, 1837 Ahmad, Sana ...... 2226 Alves e Silva, T. L...... 1323 Apodaca, Gerard ...... 1113, 2125 Ahmed, Khalil ...... 1355 Alviar, Abigail F...... 1138 Apostolopoulou, Maria ...... 894 Ahmed, Noveera ...... 988 Alworth, Samuel V...... 1942 Apostolou, Sinoula ...... 1812 Ahmed, Sohail ...... 1707 Aly, Mohamed R. E...... 831 Appleton, Paul ...... 92 Ahn, Jeongeun ...... 1059 Amann, Kurt J...... 2380 Araake, Minako ...... 1341 Ahn, Jeong ...... 1805 Amaral, Vivian ...... 1182 Arachchige Don, Aruni S...... 1359, 1546 Ahn, Kyungseop ...... 881 Amargo, Evangeline ...... 2356 Araki, Norie ...... 158 Aikawa, Fumiko ...... 1225 Amaro, Ana C...... 1496 Araki, Wataru ...... 1883 Aït-Slimane, Tounsia ...... 2071, 2119 Amatangelo, Michael D...... 1573 Arama, Eli ...... 86 Aitchison, John D...... 1625, 1965 Amblard, François ...... 360 Aranda-Espinoza, Helim ...... 1420, 1421, 1468 Aiyama, Shigeo ...... 345 Ambrus-Aikelin, Geza ...... 1392 Araoka, Toshikazu ...... 524 Ajo-Franklin, Caroline ...... 8 Amelio, Antonio L...... 1598 Arata, Toshiaki ...... 390 Akeson, Ann L...... 1906 Amidi, Fataneh ...... 823, 1973, 2342 Aratyn, Yvonne S...... 1702 Akhmanova, Anna ...... 20, 48, 694, 708, 717 Amieva, Manuel ...... 1478 Araujo, Daniela D...... 1395 Akihito, Inoko ...... 2351 Amin, Niranjana ...... 2350 Arauz, Patricia S...... 1777 Akin, Brian ...... 1741 Amin, Palak ...... 2121 Aravin, Alexei ...... 2440 Akin, Orkun ...... 484, 1634 Amiri, Mandana ...... 2280 Archambault, Jean-Christophe ...... 1222 Akiyama, Hiroki ...... 1711 Amore, Allison ...... 1741 Archambault, Vincent ...... 2205 Akiyama, Yuko ...... 73 Amponsah, Naa ...... 1795 Arends, Tom J...... 1117, 1121 221 AUTHOR INDEX The American Society for Cell Biology 47th Annual Meeting December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

Argon, Yair ...... 177, 1008, 2201 Bannerman, Douglas D...... 344 Ariel, Pablo ...... 2404 B Bansal, Nidhi ...... 1525 Ariga, Toshio ...... 1069 Ba, Xiaolan ...... 880 Banski, Piotr ...... 502 Arikawa, Emi ...... 106 Baas, Peter W...... 2294, 2295, 2296 Bao, Gang ...... 127 Arima, Kiminobu ...... 375 Babic, Ivan ...... 125 Bao, Xiaomin ...... 109, 2407 Arimura, Nariko ...... 775 Baboolal, Thomas G...... 960, 961 Bär, Harald ...... 2339 Ariola, Florly S...... 1137 Bacabac, Rommel G...... 1636 Baraban, Jay ...... 1307 Arispe, Nelson J...... 1884, 1886 Bacallao, Robert L...... 1815 Barber, Diane L...... 1026, 1779 Armani, Andrea M...... 2428 Bach, Leon A...... 522 Barber, Matthew ...... 629 Arneman, Daniel K...... 481 Bachinski, Linda L...... 566 Barbolina, Maria ...... 883 Arnold, Martha S...... 6 Backer, Jonathan M...... 609 Barbosa Sabanero, Karla A...... 440 Arora, Pamela D...... 1759, 2308 Backer, Stéphanie ...... 2301 Barbosa-Sabanero, Gloria ...... 440, 530 Arregui, Carlos O...... 364 Bacskai, Brian J...... 1095 Barbour, Leslie ...... 618 Arrigo, Cindy ...... 1544 Bacso, Zsolt ...... 2073 Barchick, Fabiane ...... 1182 Arriola, Aileen ...... 246 Badano, Jose L...... 1813 Bard, Martin ...... 174 Arroyo, Armando ...... 2051 Bader, Jason ...... 1490 Barda-Saad, Mira ...... 556 Artabazon, Nicholas B...... 405 Badiane, Fatu ...... 1277 Bardag-Gorce, Fawzia ...... 823, 1973 Artalejo, Cristina R...... 707 Bae, Jeom Il ...... 1781 Bareiss, Sonja ...... 376 Artemenko, Yulia ...... 602 Bae, Jae-sung ...... 1878 Barfod, Elisabeth ...... 700 Arvan, Peter ...... 1157 Bae, Sun Sik ...... 421, 603 Barger, Steven W...... 785 Asıcıoglu, Faruk ...... 1227 Bae, Young min ...... 1127 Baril, J...... 2018 Asabere, Nana ...... 1277 Bae, Yoonhee ...... 2154 Barkans, Ashleigh ...... 2053 Asai, David J...... 490 Bae, Yun Kyung ...... 572 Barlowe, Charles ...... 165, 2108 Asano, Atsushi ...... 2059, 2060, 2433 Baek, Hyunhyo ...... 1762 Barnat, Monia ...... 2281 Asano, Tomiko ...... 1476 Baepler, Paul M...... 1749 Barnes, Anthony P...... 1053 Asbrock, Nick ...... 878 Bagalb, Hussein ...... 580 Barnes, Georjana ...... 1645 Asbury, Charles L...... 1445, 1517, 1644 Baggs, Julie E...... 1598 Barnes, Natalie Y...... 1603 Ascione, Marc ...... 1023 Bagnat, Michel ...... 88 Barnett, Petrina K...... 1073 Asenjo, Ana B...... 832 Bagorda, Anna ...... 413 Barnhart, Erin L...... 1638 Ash, Jason ...... 2053 Bahmanyar, Shirin ...... 1428 Baron, Rudi ...... 1079 Ashcroft, Felicity J...... 406, 408 Bai, Ting ...... 192 Barr, Valarie A...... 553, 556, 810 Ashfag, Myla ...... 1730 Baibakokv, Boris ...... 2021 Barral, Yves ...... 1515 Ashworth, Sharon L...... 923 Baik, Min-Jung ...... 2198 Barrantes, Francisco J...... 2432 Asiedu, Michael ...... 1032 Bailey, Aaron O...... 862 Barreiro, Gabriela ...... 1779 Asimaki, Angeliki ...... 907 Bailey, Melanie L...... 2156 Barrera, Jose A...... 1439 Askautrud, Hanne A...... 546 Baillie, David L...... 2056 Barres, Ben A...... 2399 Askham, Jon M...... 744 Bailly, Christian ...... 1435 Barroso, Margarida ...... 1706, 2127 Askwith, Candice ...... 459 Baird, Barbara A...... 170, 552, 612, 1844, 2430 Barry, Justine ...... 2118 Asmussen, Hannelore ...... 1269 Baitaluk, Mihail ...... 1631 Barry, Nicholas P...... 1128 Aso, Hisashi ...... 73 Bakeeva, Lora ...... 1289 Barth, Angela I. M...... 1428 Asselin, Claude ...... 1223 Baker, Aaron ...... 873 Bartoli, Kristen M...... 1730 Astuto-Gribble, Lisa ...... 2079 Baker, C...... 1764 Bartolini, Francesca ...... 1450 Ataullakhanov, Fazly I...... 1645, 2207 Baker, Norman M...... 1489 Barton, Elizabeth ...... 1389 Atkins, Benjamin ...... 926 Baker, Susan M...... 919 Basehore, S ...... 1232 Atkinson, Simon J...... 445, 1815 Baker, Thomas ...... 1538 Basile, John R...... 1902 Atomi, Yoriko ...... 712 Bakhoum, Samuel F...... 2214 Basrai, Munira A...... 1494 Attias, M...... 1323 Baksh, Shairaz ...... 229, 2168, 2169 Bass-Zubek, Amanda ...... 2356 Au, Catherine E...... 1627 Bakthavatsalam, Deenadayalan ...... 427 Bassell, Gary J...... 962, 1263 Au, Wei-Chun ...... 1494 Bal, Vineeta ...... 533 Bassereau, Patricia ...... 831 Audhya, Anjon ...... 992, 2141 Balagopalan, Lakshmi ...... 553, 556 Bast, Robert C...... 1359 Auguste, Jensen O...... 1285 Balanis, Nikolas G...... 1768 Basto, Renata ...... 1425 Augustine, Robert ...... 480 Balasinor, Nafi sa ...... 951 Basu, Roshni ...... 1656 Augusto, Taize M...... 325 Balch, William E...... 1621 Batac, Joseph ...... 1511 Aurora, Rajeev ...... 1969 Balda, Maria S...... 870 Batchelder, Ellen L...... 2260 Austin, Christopher P...... 103, 1653 Baldassarre, Massimiliano ...... 1761, 2415 Bates, Carlton ...... 379 Avalos-Diaz, E...... 784 Baldwin, Amy ...... 581 Bates, Ryan ...... 2053 Avila, Jesus ...... 760 Balkin, Daniel M...... 829 Batra, Harish ...... 154 Awan, Aashir ...... 450 Ball, DeAnna ...... 2194 Batra, Sushil ...... 1805 Axelrod, Jeff ...... 1478 Ballif, Bryan A...... 723 Batsché, Eric ...... 33 Ayala, Alexandra E...... 1891 Ballou, Jaron ...... 174, 175 Battelle, Barbara-Anne ...... 1691, 1692 Ayala-Izquierdo, José L...... 1294 Baltes, Nicholas ...... 175 Battini, Lorenzo ...... 1830 Ayalon, Gai ...... 2398 Balusu, Ramesh ...... 1859 Bauer, Roslyn A...... 1151 Aye, Myo-Pale’ ...... 1119 Bamburg, James R...... 442, 1051 Bauerle, Cynthia ...... 1148 Azambuja, Jr., Nilton ...... 326 Banales, Jesus M...... 455, 456, 1393, 1816 Bauernfeind, Ryan W...... 931 Azarenko, Olga ...... 1457 Bandyopadhyay, Sourav ...... 1629 Baughman, Cassandra ...... 164 Azevedo, Isabel ...... 1347 Banerjee, Nirupama ...... 1913 Baumeister, Ralf ...... 1104 Azhar, Salman ...... 1221, 278 Banes, Albert J...... 917, 1208, 2174 Baumgartner, Martin ...... 1026 Aziz, Arif ...... 234, 2035 Bang, Ok-Sun ...... 1312 Bausch, Andreas R...... 477, 2376 Aziz, Zeinab ...... 1065 Bangia, Naveen ...... 1328 Bautch, Victoria L...... 342 Azou, Yannick ...... 1954 Banker, Gary ...... 1725 Bauza, Eric ...... 1066, 1852, 2167 Azzarone, Bruno ...... 548 Banks, Lawrence ...... 130, 2131, 2170 Baxter, Sarah C...... 879 222 The American Society for Cell Biology 47th Annual Meeting AUTHOR INDEX December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

Bayard, Elisa ...... 2022 Bergquist, Kristen E...... 178 Bishop, Nick ...... 1023 Bazellieres, Elsa ...... 1673 Berke, Gideon ...... 1201, 1202 Bissell, Mina J...... 1071, 1230, 2418 Bazinet, Christopher ...... 982 Berl, Tomas ...... 1128, 1966 Bisson, Leticia F...... 1357 Beach, Jordan ...... 660, 2325 Berland, Ludwig ...... 831 Bista, Bigyan ...... 246 Beacham, Dan ...... 1842 Berman, Judith ...... 2227 Biswas, Chhanda ...... 177, 1008 Beacham, Dorothy A...... 1573 Bermudez, Maria ...... 1153 Bizario, João C. S...... 1395 Beachy, Philip A...... 1813 Berna, Linda ...... 517 Black, Carol ...... 318 Beadle, Christopher ...... 1415 Bernal, Eleonora ...... 1177, 1178 Black, Douglas ...... 125 Beal, Allison M...... 892 Bernal, Paula J...... 1904 Blacketer, Melissa J...... 2407 Beales, Philip L...... 1813 Bernard, Lam ...... 1921 Blackstone, Craig ...... 2114 Bean, Greg J...... 2380 Bernard, Philip ...... 1526 Blackwell, Jillian ...... 1363 Bear, James E...... 431, 596, 1014, 1409 Bernd, Karen K...... 83, 981 Blagoi, Elena ...... 585 Beard, Daniel A...... 2138 Bernot, Kelsie M...... 553 Blair, Cheyne ...... 2199 Bearer, Elaine L...... 1386 Berns, Michael W...... 1489 Blanch, Harvey ...... 1912 Beauchamp, Elspeth ...... 236 Bernstein, Sanford I...... 2316 Blanchard, Elisabeth G...... 2137 Beaven, Michael ...... 554 Berra, Alejandro ...... 287 Blanchoin, Laurent ...... 1017, 1019, 1030 Bechtel, Charity ...... 1358 Berrier, Allison ...... 1793 Blankenship, J. Todd ...... 1609 Becker, Lewis C...... 151 Berro, Julien ...... 1017, 1019 Blankman, Elizabeth ...... 1715 Beckerle, Mary C...... 222, 1715 Berrodin, Tom ...... 1926 Blanpied, Thomas A...... 49 Beebe, Stephen J...... 684 Berry, Robert W...... 1893 Blaschitz, Astrid ...... 1907, 1219 Beenders, Brent ...... 1653 Bertet, Claire ...... 2318 Blasier, Kiev ...... 1199 Beguinot, Francesco ...... 173 Bertling, Enni ...... 1015 Blau, Helen ...... 2452 Beihoffer, Lauren A...... 2113 Berto, Gaia ...... 654, 1272 Blitzer, Andrea L...... 437 Beishir, Stephen C...... 2211 Bertrand, Gyslaine ...... 1130 Blobel, Gunter ...... 1655 Belanger, Kenneth D...... 629, 1969 Bess, Cameron D...... 542 Bloch, Robert J...... 1004 Belanger, Karyn G...... 1969 Betapudi, Venkaiah ...... 2325, 2326 Bloch-Gallego, Evelyne ...... 2301 Belen-Rivera, Jessica ...... 977 Bettenbuehl, Mario ...... 443 Bloom, George S...... 1024 Bell, Aaron ...... 446 Bettencourt-Dias, Monica ...... 1422, 1423 Bloom, Kerry ...... 968, 1498, 1508, 2227 Bell, Alexander W...... 1627 Beug, Shawn T...... 2030 Bloomekatz, Joshua ...... 793 Bell, John D...... 1751 Beussman, Doug ...... 948 Blough, Britton A...... 2183 Bell, Russell ...... 1629 Bewersdorf, Joerg ...... 1419, 2425 Blow, J. J...... 2210 Bell, Stephen P...... 1541 Beyret, Ergin ...... 2451 Blumberg, Daphne D...... 186 Bell, Wade E...... 1292 Bezanilla, Magdalena ...... 480 Blume, Yaroslav B...... 1459, 1462, 2334 Bellaiche, Yohanns ...... 1611 Beznosov, Sergey ...... 1699 Blumer, Kendall ...... 1565 Bellin, Robert ...... 1776 Bhadriraju, Kiran ...... 310, 1572, 1941 Blystone, Scott D...... 1036 Bellini, Michel ...... 135, 1653 Bhandari, Deepali ...... 286 Boca, Manila ...... 1819 Bello, Paul ...... 1189 Bhandoola, Avinash ...... 930 Bocock, Jeffrey P...... 1983 Belmont, Andrew S...... 110, 2407, 2408 Bhanot, Kunal ...... 993 Boczkowska, Malgorzata ...... 486, 488 Belostotsky, Dmitry ...... 1630 Bhatnagar, Rakesh ...... 1913 Bodenburg, Yvonne ...... 242 Belt, Patricia A...... 1854 Bhattacharya, Rajat ...... 2336 Bodin, Stéphane ...... 355 Beltrame, Miriam ...... 1182 Bhattarai, Hitesh ...... 2242 Bodnar, Richard J...... 693 Belwal, Mukta ...... 2239 Bhola, Patrick D...... 669, 670 Boehm, Heike ...... 1801 Belyantseva, Inna A...... 958, 1709 Bhujwalla, Zaver M...... 1791 Boem, Manfred ...... 1950 Belzile, Olivier ...... 449 Bi, Erfei ...... 668, 1039, 2242, 2244 Boettiger, Alistair ...... 221 Bembenek, Joshua N...... 1520 Bialas, Nathan ...... 465 Boettiger, David ...... 61, 320, 323 Bement, William M...... 472, 482, 656, 663, 955 Bialek, William ...... 1 Bogdan, Sven ...... 1680 Ben-Harush, Kfi r ...... 35 Bian, Qian ...... 2408 Bogunovic, Branka ...... 2166 Ben-Tekaya, Houchaima ...... 2105 Bianchi, Federico ...... 654 Bohannon, Kevin P...... 1447 Ben-Yehuda, Sigal ...... 853 Bicek, Andrew D...... 1639 Bohil, Aparna B...... 956 Ben-Yehudah, Ahmi ...... 563, 1756 Bidwell, Joseph P...... 1771 Bohnsack, Richard N...... 288 Benabentos, Rocio ...... 1809 Bieber, Allan ...... 2037 Bola, Becky M...... 1727 Benaroch, Philippe ...... 1728 Bieling, Peter ...... 19, 743, 1453, 2241 Bold, Michael ...... 1161 Benesh, Andrew E...... 1685 Biemesderfer, Daniel ...... 1694, 2094 Boletta, Alessandra ...... 1819 Benian, Guy M...... 737, 738, 739, 740, 1927 Bienengraeber, Martin ...... 1296 Bollain y Goytia-De la Rosa, J J...... 784 Benistant, Christine ...... 2072 Bienkowska, Dominika ...... 167 Bolshakova, A...... 1577, 1769 Benjamin, Jacqueline ...... 336 Biggins, Sue ...... 1497, 2220 Bolterauer, Hannes ...... 1457 Benjamin, Sigi ...... 86, 1106 Bilan, Philip ...... 274 Bomberger, Jennifer ...... 1328 Bennett, Brian T...... 2425, 2426 Billadeau, Daniel D...... 1097 Bonamy, Ghislain ...... 1706, 2127 Bennett, James P...... 178 Billen, Lieven P...... 806 Bond, Lisa M...... 968 Bennett, Vann ...... 998, 2075, 2398 Binas, Bert ...... 212 Bond, Meredith ...... 891 Benovic, Jeffrey L...... 286 Bindels, René J. M...... 1110 Bond, Wesley ...... 518, 520 Bentley, Amber ...... 1795 Binder, Lester I...... 1893 Bonder, Edward M...... 2050 Benz, Karin ...... 1191 Binker, Marcelo ...... 1331 Bonds, Michael ...... 1413A Berardini, Mark ...... 1919 Binns, Derk ...... 512 Bondzi, Cornelius ...... 1854 Berardone, Neda ...... 24 Bird, Gary S...... 1131, 1132 Bonifacino, Juan S...... 826, 1091, 1108, 1821 Berbari, Nicolas F...... 459, 462 Bird, R. Curtis ...... 1534 Bonne, Gisele ...... 560 Bergelson, Jeff ...... 539 Biri, Stéphanie ...... 1200 Bonnemann, Carsten G...... 1899 Berger, Anthony ...... 2368 Birkó, Zsuzsanna ...... 2073 Bonner, William ...... 820 Berger, Eric G...... 1993 Birnbaum, Morris ...... 421, 603 Bonte, Frédéric ...... 1222 Bergeron, John J. M...... 1627 Bishop, Georgia A...... 462 Bonzo, Jeremy R...... 730 Bergkvist, Magnus ...... 1203 Bishop, Hannah I...... 1053 Booth, Brian W...... 237, 578 223 AUTHOR INDEX The American Society for Cell Biology 47th Annual Meeting December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

Boren, Kathryn ...... 1751 Breusegem, Sophia Y...... 1128 Burgess, Daniel J...... 1309 Borg Capra, Catherine ...... 777 Brewer, Paul ...... 391 Burgess, David R...... 576, 1044 Borisy, Gary G...... 1702 Bridges, Lance C...... 1075 Burgess, Z...... 1764 Borleis, Jane ...... 415 Brieher, William M...... 2390 Burghoorn, Jan ...... 454 Borutinskaite, Veronika V...... 545 Briggs, James M...... 1402 Burgo, Andrea ...... 1262 Borzok, Maegen A...... 1004 Briggs, Laura E...... 1837 Burgos, Mario H...... 769 Boscher, Cécile ...... 361 Briggs, Michael W...... 321 Burgos, Patricia V...... 826 Bose, Indrani ...... 1039 Brigstock, David R...... 2194, 2444 Burgstaller, Gerald ...... 1778, 2363 Bosio, Ylenia ...... 1272 Brill, Julie A...... 982 Burkart, Mark ...... 549 Bosnjak, Zeljko ...... 1296 Brink, Peter R...... 909 Burke, Julian ...... 576 Boss, Wendy F...... 1563 Brinster, Lauren R...... 2305 Burke, Sean ...... 334 Bossie, Sheena ...... 1741 Bristow, Jeanne M...... 401 Burkel, Brian ...... 472 Bossinger, Olaf ...... 2362 Brodeur, Michael ...... 337 Burkhardt, Janis K...... 1008, 930 Botchwey, Edward A...... 215 Brodovitch, Alexandre ...... 1976 Burman, Jonathon L...... 1996 Botstein, David ...... 1148 Brodsky, Frances M...... 2011 Burnett, Lindsey ...... 2037 Boucher, Ilene ...... 75 Brodsky, Jeffrey L...... 51, 1158 Burnette, Dylan T...... 2298 Bouck, David C...... 1508 Broekhuizen, Roel ...... 550 Burnham, Nancy A...... 1196 Boudreau, François ...... 1223 Brofman, Paulo ...... 1182 Burns, Claire ...... 638 Bouhassira, Eric E...... 450 Brogden, Kim A...... 463 Burnside, Beth ...... 1693 Boujemaa-Paterski, Rajaa ...... 1017 Bronk, Peter ...... 1264 Burridge, Keith ...... 1810, 2171, 43 Boukari, Hacéne ...... 1089 Bronson, Sarah K...... 207 Bursać, Dejan ...... 1624 Boukh-Viner, Tatiana ...... 1065 Brophy, Peter J...... 1311 Burton, Briana M...... 852, 853 Boulanger, Corinne A...... 237, 578 Brothers, John ...... 146 Busch, Albert ...... 1915, 2359 Bourassa, Sylvie ...... 91 Brouhard, Gary J...... 751 Busch, Karl E...... 750 Bourbonniere, Lyne ...... 1996 Brown, Anthony ...... 2344 Bush, Jason R...... 2036 Bourgoin, Sylvain ...... 1564 Brown, Andre E. X...... 1735 Businga, Thomas R...... 463 Bourinet, Emmanuel ...... 1130 Brown, Christopher ...... 8 Bustamante, Carlos ...... 1230, 1295 Bourque, Simon ...... 1065 Brown, Claire M...... 502 Buster, Daniel W...... 641 Bouton, Amy H...... 2274 Brown, Deborah A...... 258, 297, 511 Bustin, Michael ...... 1233, 157, 2265, 227, 2409, 70 Boutros, Michael ...... 191 Brown, Elizabeth E...... 2248 Butcher, E. C...... 1390 Bovenschen, Niels ...... 550 Brown, Jay C...... 1199 Butler, Christine A...... 1288 Bowen, James W...... 99 Brown, Matthew D...... 426 Butt, Tauseef R...... 99 Bowerman, Bruce ...... 496, 634, 713 Brown, Sherry-Ann ...... 1551 Buttery, Shawnna ...... 23 Bowman, Grant R...... 1040 Brown, Terry R...... 615 Buttke, Danielle E...... 2059, 2060, 2433 Boyce, Mary C...... 2374 Brown, William J...... 511, 2008 Buvelot-Frei, Stephanie ...... 2220 Boyle, J...... 1625 Brueckner, Martina ...... 797, 1602 Byerly, Diane ...... 1172, 357 Boyles, Serenity ...... 2037 Brugge, Joan S...... 2185, 2420 Byfi eld, F. J...... 1850 Braasch, Fenja ...... 1198 Bruner, Kimberly K...... 1204 Byhower, Frances M...... 1356 Bradburn, Helen ...... 1189 Brunet De Carvalho, Nicole ...... 613 Byhower, Lidia J...... 1356 Bradbury, Neil ...... 2125 Brüning-Richardson, Anke ...... 744 Byrd, Christy ...... 1579 Bradford, Jolene A...... 1539 Brunner, Abigail M...... 1854 Byrd, Debra L...... 1176 Bradke, Frank ...... 96, 1051 Brunner, Damian ...... 19, 745, 750, 941, 1453, 1455 Byrd, Shere A. K...... 1313 Bradshaw, Charles ...... 1984 Brunt, Elizabeth M...... 2365 Byskov, Anne G...... 450 Bradshaw, William S...... 1751 Bry, Lynn ...... 426 Byun, Hee Sun ...... 1562, 1860, 1863, 1865 Brady, Scott T...... 2295 Bryantseva, Sofi a A...... 1664 Byun, Jin-woo ...... 1399, 2041, 2042, Braendle, Christian ...... 795 Bryce, Nicole S...... 442, 936 2043, 2044, 2047, 2176 Brahmachari, Vani ...... 1525 Brzeska, Hanna ...... 1690 Brakebusch, Cord ...... 1051 Brzezinska, Agnieszka A...... 1340 C Braman, J...... 1232 Bu, Guojun ...... 593, 2101 Cabartova, Zuzana ...... 1155 Bramwell, Jeremy ...... 337 Bu, Wenyu ...... 1707 Cabral, Fernando ...... 2336 Branca, Maria ...... 90 Buac, Kristina ...... 2200 Cabrera, Rodrigo ...... 705 Branch, Angie ...... 1204 Bubb, Michael R...... 476 Cadilla, Carmen L...... 1821 Brandeis, Michael ...... 2161 Bubulya, Athanasios ...... 160 Cafaro, Matias J...... 647 Brandl, Christopher J...... 2156 Bubulya, Paula A...... 160 Cai, Dawen ...... 833 Brandman, Onn ...... 9 Buchholz, Frank ...... 1984 Cai, Liang ...... 1014 Brangwynne, Cliff P...... 836 Bucki, Robert ...... 1850 Cai, Lanlan ...... 1958 Brantly, M...... 1232 Buckwold, Lyana ...... 1741 Cai, Qian ...... 1275 Brar, Simuran K...... 2143 Budinger, Gregory R. S...... 1764 Cai, Shang ...... 631, 1723 Brasier, Allan ...... 148 Buechner, Matthew ...... 765 Cai, Shenshen ...... 312 Brasnjo, Gabor ...... 2404 Buehner, Norene A...... 190 Cai, Weili ...... 109, 2407 Bratman, Scott V...... 754 Buhler, Jeremy ...... 1743 Cai, Wen Q...... 2025 Braun, Werner ...... 726 Buhusi, Mona ...... 2293 Cai, Xin ...... 2233 Brautigan, David L...... 2225 Bulic, Marinka ...... 1871 Cai, Ying ...... 1024 Breakefi eld, Xandra O...... 1376 Bulinski, J. Chloe ...... 1124, 1456, 2328, 2329 Caixia, Jin ...... 584 Brecht, Andreas ...... 1934 Bunai, Fumihide ...... 1256 Calderwood, David A...... 1761, 2415, 59 Breckenridge, Mark T...... 25, 1516, 2323 Bünger, Rolf ...... 1281 Caleffi , Angela ...... 2353 Brekosky, Jill ...... 563 Bupp, Jennifer M...... 13 Calloway, Nathaniel T...... 552 Bremner, Kathleen H...... 1661, 1662 Burakov, Anton ...... 24 Camacho, Marcela ...... 527, 528 Brengman, Joan M...... 781 Burden, Jemim ...... 1109 Camand, Emeline ...... 359 Brenneck, Julius ...... 2440 Burge, Christopher B...... 2439 Camaren, Jade C...... 1313 Bresnick, Anne R...... 1484, 1485, 1486 Burger, Koert N. J...... 2104 Camargo, María Helena ...... 527 224 The American Society for Cell Biology 47th Annual Meeting AUTHOR INDEX December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

Camargo, Maria D...... 932 Castello-Cros, Remedios ...... 1573 Chang, Yih-Leong ...... 1529 Camera, Paola ...... 1272, 654 Castillo, Cecilia ...... 1265 Changpriroa, Cattlena ...... 1839 Cameron, Lisa A...... 1506 Castillo-Pichardo, Linette ...... 1344 Chao, Gene ...... 1642 Cameron, Thomas O...... 892 Castillon, Guillaume ...... 824 Chao, Jerry ...... 2424 Cammarato, Anthony ...... 2316 Castle, Sherry ...... 2060 Chao, Moses V...... 1271 Cammer, Michael ...... 1485 Castro, Carlos ...... 563 Chao, Sylvia T...... 243 Camonis, Jacques ...... 1103, 1728 Catz, Sergio D...... 1340 Chao, Wei T...... 1005, 406, 408 Campbell, A. Malcolm ...... 1741 Caudell, Eva G...... 2137 Chapados, Brian R...... 1489 Campbell, Chris C...... 849 Caudy, Amy A...... 144 Chapleau, Christopher ...... 45, 1268 Campbell, Iain D...... 59 Cavallo, Jaime ...... 90 Chaqour, Brahim ...... 672, 690 Campbell, Jay ...... 1520, 2249 Cavey, Matthieu ...... 999 Chari, Vandhana M...... 269, 1874 Campbell, Joseph L...... 1245, 1952 Cavicchia, Juan Carlos ...... 769 Charlebois, Blake ...... 1500 Campbell, Lioudmila A...... 856 Caviston, Juliane P...... 2091 Charles, Halsted H...... 2342 Campbell, Sharon L...... 481 Cavnar, Peter J...... 444 Charrasse, Sophie ...... 355, 362 Campos, Isabel ...... 87 Cayhuti, Thomas ...... 704 Charrin, Benedicte C...... 1509 Cancino, Jorge ...... 2126 Cereijido, Marcelino ...... 871 Charterjee, Bishwannath ...... 1124 Cande, W. Z...... 2438 Ceresa, Brian P...... 2182, 583 Chase, Brian C...... 316 Canessa, Gisella ...... 2069 Cerra, Michael ...... 1190 Chasis, Joel ...... 1162 Canman, Julie ...... 713 Cha, Hyun-Young ...... 247 Chatterjee, Chandrima ...... 2417, 314 Canoll, Peter ...... 1415 Cha, Joonseok ...... 1596 Chaudhry, Ashutosh ...... 533 Cantele, Francesca ...... 987 Chae, Sunyoung ...... 1605 Chaudhuri, Ovijit ...... 424, 425 Cantley, Lewis ...... 1532 Chairoungdua, Arthit ...... 1145 Chaudhuri, Rittik ...... 1091 Cantor, Charles R...... 105 Chaisri, Urai ...... 1330 Chaudhuri, Tathagata ...... 312 Canutescu, Adrian ...... 1812 Chait, Brian T...... 115, 1626 Chauvin, Stéphanie ...... 2303 Cao, Danping ...... 894 Chakrabarti, Lina ...... 565 Chaves, David R...... 2010 Cao, Hong ...... 1094 Chakraborty, Chandrani ...... 2399 Cheah, Kathryn S. E...... 570 Cao, Zheng ...... 1628, 2012, 2142 Chakraborty, Joana ...... 580 Chee, Kaa-Sandra N...... 908 Capalbo, Luisa ...... 2205 Chalam, Karkala V...... 74 Cheeseman, Iain M...... 1491, 1645 Capco, David G...... 85 Chalker, Douglas L...... 1654 Chekanova, Julia ...... 1630 Capetanaki, Yassemi ...... 2343 Chamberlain, M. D...... 2189, 2190 Chellaiah, Meenakshi A...... 1581, 1583, 1704 Caplan, Michael J...... 1145, 2076 Chambon, Valerie ...... 831 Chen, Alex Y. W...... 2121 Caplan, Michael R...... 1574 Chamorro, David ...... 865 Chen, Ben-Kuen ...... 137 Caplan, Steve ...... 1105 Chamot, Christophe ...... 1262 Chen, Beibei ...... 1967 Caplen, Natasha J...... 2441 Chan, Agnes ...... 2288 Chen, Buxin ...... 562 Carag, Christine ...... 1000 Chan, Bianca S...... 1616 Chen, Chun-Hau ...... 1529 Cardoso, Alexandre B...... 319, 325 Chan, Danny ...... 570 Chen, Chun ...... 1806 Cardoso de Almeida, M. F...... 1323 Chan, Fok Vun ...... 1394 Chen, Chun-ting ...... 2252 Carin, Mahmut ...... 1068, 1227 Chan, Gordon ...... 1605 Chen, Christopher .....232, 233, 313, 323, 2414, 2419 Carlin, Cathleen R...... 2074 Chan, Gordon K. T...... 2228, 2238 Chen, Feng ...... 2205 Carlisle, Diane ...... 1756, 563 Chan, Jason Y...... 1837 Chen, Frank S...... 1199 Carlisle, Holly J...... 1267 Chan, Ln ...... 1163 Chen, Hsiang-Chin ...... 1351 Carlos, Vanessa ...... 87 Chan, May ...... 61 Chen, Hung-Wei ...... 1351 Carlson, C. G...... 1817, 1823 Chan, Pamela P. F...... 1358 Chen, Hsin-yi ...... 1567 Carlsson, Anders E...... 2366 Chan, Sara ...... 1277 Chen, Huaming ...... 1630 Carlton, Peter M...... 2423 Chan, Siu Ming M...... 770 Chen, Inn-Inn ...... 1461 Carmeliet, Geert ...... 749 Chan, Tim ...... 2190 Chen, Jing ...... 1094, 1097 Carmeliet, Peter ...... 786 Chan, Wai-Yee ...... 211 Chen, Jue ...... 1896 Carmicle, Stephanie ...... 1983 Chan, Walter ...... 2341, 2349 Chen, Jie ...... 2193 Carmody, Sean R...... 133 Chandhok, Namrata S...... 640 Chen, Ji H...... 821 Carmona, Carmelo ...... 1821 Chandler, Douglas ...... 2037 Chen, Kevin ...... 236 Caron, Danielle ...... 91 Chandler, Julie M...... 1396 Chen, Lizhen ...... 1061 Carr, Heather S...... 2171 Chandrachud, Uma ...... 1521 Chen, Lingyi ...... 1303 Carr, Tiffany M...... 1658 Chandran, Suchismita ...... 2009 Chen, Michael ...... 960 Carrasco, Yasmin ...... 685 Chang, Andrew ...... 1065 Chen, Ping-Chung ...... 1373 Carrel, Damien ...... 777 Chang, Binyue ...... 74 Chen, Pei-Hong ...... 153 Carrie, Redinger ...... 1756 Chang, Chuan-Yuan ...... 248 Chen, Pin-I ...... 2093 Carsten, Sandra ...... 1198 Chang, Dayoung ...... 247 Chen, Qian ...... 2222 Carstens, Russ P...... 585 Chang, Eric ...... 705 Chen, Ruey-Hwa ...... 1529, 1567, 2351 Carter, Andrew ...... 494 Chang, Fred ...... 1038, 1656, 2064, 754 Chen, Ruju ...... 2194 Carvalho, Ana ...... 2254 Chang, Han-Wen ...... 1537 Chen, Rong ...... 2394 Carvalho, Hernandes F...... 319, 325 Chang, Henry ...... 192 Chen, Shaoqiong ...... 1824 Carvalho, Pedro ...... 1719 Chang, Howard Y...... 1587 Chen, Show-Li ...... 153, 582 Carvalho-Santos, Zita ...... 1422 Chang, Jennifer ...... 1237 Chen, Sen ...... 593 Casanova, James E...... 1339 Chang, Kwang-Yu ...... 137 Chen, Steven C...... 1063 Case, Lindsay B...... 957 Chang, Kai ...... 771 Chen, Wan-Ru ...... 1351 Casellas, Rafael ...... 116 Chang, Long-Sen ...... 2283 Chen, Wen-Huei ...... 616 Casey, Patrick J...... 1428 Chang, Robert ...... 1193 Chen, Xian-Ming ...... 531, 532 Cashon, Robert E...... 98 Chang, Steve ...... 1124 Chen, Xuejun ...... 65 Cassar, Lucy ...... 2178 Chang, Ssu-Wei ...... 582 Chen, Xinhua ...... 684 Cassimeris, Lynne ...... 1450, 762 Chang, Wen-Chang ...... 137 Chen, X...... 747 Castaneda, Mauricio ...... 287 Chang, Wakam ...... 967 Chen, Yaodong ...... 1465 225 AUTHOR INDEX The American Society for Cell Biology 47th Annual Meeting December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

Chen, Yih-Tai ...... 1539 Choi, Dongwon ...... 2154 Cohen, Daniel M...... 233 Chen, Ying ...... 1956 Choi, Ik Sung ...... 172 Cohen, Jesse B...... 1317 Chen, Yongqing ...... 2026 Choi, Jun-Sub ...... 1900 Cohen-Fix, Orna ...... 1245, 1952, 618, 624 Chen, Yanmei ...... 2054 Choi, John K...... 930 Cohn, Stanley A...... 2278 Chen, Yun ...... 2072 Choi, Kuicheon ...... 1548 Colakoglu, Gulsen ...... 2344 Chen, Yi-Ru ...... 2351 Choi, Kyung-hee ...... 156 Cole, Charles N...... 133 Chen, Yongsheng ...... 85 Choi, Seo Yeon ...... 101 Cole, D. G...... 988 Chen, Yan- H...... 867 Choi, Soo Jin ...... 572 Colicelli, John ...... 1261 Chen, Zulin ...... 379 Choi, Seunga ...... 683 Colin, Emilie ...... 1607 Cheney, Clarissa M...... 2121 Choi, Su-Yong ...... 881 Collesi, Chiara ...... 2404 Cheney, Richard E...... 956, 957, 963, 965 Choi, Youngil ...... 1059 Collette, John R...... 1090 Cheng, C. Yan ...... 897 Choi, Young-Ae ...... 1304, 1312 Collin, Olivier ...... 1571 Cheng, Catherine Q...... 233, 2419 Choi, Yongwon ...... 683 Collinet, Claudio ...... 1984 Cheng, Connie Y...... 2121 Choil, Byung Lyul ...... 1860 Collins, James J...... 105 Cheng, Elaine ...... 1632 Chopra, Ashok K...... 549 Collins, Nicholas S...... 2256 Cheng, Fan ...... 2153, 2188 Chou, Ying-Hao ...... 2361 Collins, Ruth ...... 2129 Cheng, Ling ...... 2397 Chounlamountri, Naura ...... 786 Collins, S. D...... 1390 Cheng, Shen ...... 1338 Chow, Betty W. Y...... 1084 Collins, Sean R...... 1632 Cheng, ShiBin ...... 1386 Chow, Carson C...... 217 Collins, Tony J...... 1078 Cheng, Xun ...... 1188 Chowdhry, Annam ...... 672 Colognato, Holly ...... 1763, 1765, 1767 Cheng, Ya-Wen ...... 582, 1858 Chowdhury, Alyssa ...... 2322 Colombini, Marco ...... 805 Cheng, Yuki ...... 1942 Chowdhury, Ashis K...... 155 Colombo-Maurat, Kelly ...... 1509 Cheng, Zhongyi ...... 1535 Chowdhury, Farhan ...... 1571 Comiskey, Erin O...... 1008 Cheng, Zhi-Jie ...... 296 Christensen, Soren T...... 450 Comolli, Luis R...... 1040 Cheng-Yang, Chou ...... 592 Christianson, Olav ...... 202 Composto, Russell J...... 320 Cheong, Frances Ka Yan ...... 1668 Christofi s, Andressa ...... 1182 Compton, Duane A...... 1500, 1648, 2208, 2214 Cherla, Rama P...... 1327 Chu, Vi ...... 1188, 878 Comunale, Franck ...... 355, 362 Chernoff, Jonathan ...... 323 Chu, Zhaoqing ...... 2150 Conboy, John ...... 350 Chernoff, Yury O...... 562 Chua, Jennifer ...... 2315 Concha, Ilona ...... 521 Cherukuri, Srujana ...... 227 Chuang, Han-Yu ...... 575 Conchello, Jose-Angel ...... 1642 Chesarone, Melissa A...... 1030 Chuang, Jen-Zen ...... 2132 Condeelis, John S...... 22, 334, 434, 811, 1472 Cheshire, Alan M...... 1010 Chuang, Ling-shiang S...... 2050 Conibear, Elizabeth ...... 827 Cheung, Isla D...... 88 Chun, Justin ...... 2106, 2112 Conkright, Juliana ...... 1598 Chevalier-Larsen, Erica S...... 1887 Chung, Brian ...... 1594 Conkright, Michael ...... 1598 Chhikara, Maneesha ...... 1845 Chung, Chang Y...... 428 Connelly, Patricia S...... 733 Chi, David S...... 692 Chung, David S...... 2342 Conner, Sean D...... 1100 Chi, Liqun ...... 2174 Chung, Hyun Min ...... 1067 Connerly, Pamela L...... 293 Chi-Hung Siu, Chi-Hung ...... 2143 Chuong, Simon D. X...... 766 Connor, Crystal D...... 1854 Chia, E-sin ...... 380 Church, John ...... 2136, 2271 Connors, Shahnjayla K...... 1859 Chiang, Meng-Jung ...... 1529 Churchward, Matthew A...... 257 Conover, Gloria M...... 729 Chiarella, P. S...... 1764 Ciccone, Carla ...... 518, 520 Conrad, Michael ...... 1642 Chiarini, Luciana B...... 676 Ciceri, Gabriele ...... 1274 Consiglio, Eduardo ...... 173 Chiasson, Christine M...... 353 Cifuentes-Diaz, Carmen ...... 613 Conti, Brian ...... 52 Chiba, Akira ...... 1308 Cirillo, Jeffrey D...... 1332 Conti, Mary Anne ...... 2308, 2309 Chien, Kenneth R...... 1837 Citrin, Max ...... 1741 Contompasis, John ...... 719 Chih, Ben ...... 458 Cizmecioglu, Onur ...... 619 Contreras, Ruben Gerardo ...... 871 Chikama, Tai-ichiro ...... 864, 896 Claessens, Mireille ...... 477 Contreras-Vallejos, Erick ...... 760 Chikashige, Yuji ...... 1951 Clark, Andrew G...... 663 Cook, Esther ...... 2053 Chin, Lih-Shen ...... 1888, 1895, 1896, 1987 Clark, Emily ...... 308 Cook, Laurie B...... 275 Chini, Claudia ...... 2007 Clark, Howard ...... 26 Cook, Sungeun ...... 101 Chintala, Sreenivasulu ...... 1982 Clarke, Hamish ...... 2288 Cookson, Mark ...... 1381 Chintalapani, Ani ...... 1210 Clarke, Margaret ...... 300 Coon, Brian G...... 655, 1103 Chiodo, Vincent ...... 676 Clarke, Scott T...... 1539 Coons, Serena C...... 1384 Chiquet-Ehrismann, Ruth ...... 903 Claro, Enrique ...... 2104 Cooper, Cameron H. J...... 1940 Chirestensen, Morten O...... 118 Claude, Alejandro ...... 2106 Cooper, Chester R...... 1396 Chirila, Anda ...... 1386 Claus, Peter ...... 2282 Cooper, Jeremy ...... 1644 Chishti, Athar H...... 1708, 1724, 1804 Cleland, Megan ...... 1279 Cooper, John A...... 1671 Chiu, Yi-Jen ...... 1552 Clement, Cecilia ...... 1336 Coorssen, Jens R...... 257 Cho, Bumrae ...... 1167 Clement, Christian A...... 450 Copeland, John ...... 945 Cho, Carol ...... 492 Clemente-Guerrero, Mónica ...... 1294 Copeland, Sarah ...... 945 Cho, Hyeseong ...... 1605 Cleveland, Don W...... 1489, 1604, 2231, 2240 Copic, Alenka ...... 2118 Cho, Kyongshin ...... 1345 Clifford Hart, Dawn M...... 667 Coppens, Isabelle ...... 525 Cho, Michael ...... 1871 Clodfelter, Catherine ...... 981 Coppey, Matthieu ...... 221 Cho, Wha Ja ...... 203 Cobain, Erin ...... 1741 Coppolino, Marc G...... 1775, 62 Cho, Won J...... 255, 256 Cochiaro, Jordan ...... 32 Corbetta, Sara ...... 1274 Choe, Joonho ...... 1594, 683 Coe, Helen ...... 2034 Corda, Daniela ...... 298 Choi, Byung Lyul ...... 1562, 1863, 1865 Coelho, Ana ...... 2209 Cordeiro, M. F...... 504 Choi, Cheol Young ...... 1056 Coffey, Robert J...... 1628, 861, 2012, 2142 Corey, Seth J...... 2137, 467 Choi, Cheol Yong ...... 1524, 1528 Cohan, Christopher ...... 633, 637 Cormet-Boyaka, Estelle ...... 2085, 2103 Choi, Colin K...... 475 Cohen, Aaron ...... 931 Cornfi ne, Susanne ...... 483 Choi, Danielle ...... 1741 Cohen, A. E...... 747 Correia, John J...... 1199, 2335 226 The American Society for Cell Biology 47th Annual Meeting AUTHOR INDEX December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

Correiro, Elizabeth ...... 1350 Curran-Melendez, Sheila ...... 2293 Davis, Greg K...... 639 Corsi, Karin A...... 208 Currie, Peter D...... 1301 Davis, Graeme W...... 2397 Cortes, Christian ...... 780 Curtis, Jennifer E...... 1801 Davis, Jonathan Q...... 2398 Cortesio, Christa ...... 811 Cusimano, Vincenza ...... 2065 Davis, Michael A...... 356 Cortez, Yuan ...... 1221, 278 Cutler, Mary Lou ...... 1770 Davis, Margaret I...... 1260 Coscoy, Sylvie ...... 360 Cyr, David ...... 1065 Davis, Richard C...... 1385 Cosio, Gabriela ...... 706 Czaplinski, Kevin ...... 128 Davis, Ron W...... 57 Cossart, Pascale ...... 1335, 33 Czikora, Istvan ...... 1834 Davis, Shaun M...... 117 Costa, Gonçalo ...... 2209 Czyz, Aneta ...... 515 Davis, Sean R...... 2410 Costa, Maria Cristina R...... 1395 Davis, Trisha N...... 1445, 1517, 1644 Costaguta, Giancarlo ...... 1980 D Davis-Hanna, Amber ...... 1343, 1586 Costantini, Lindsey M...... 1848 D’Amato, Lisa ...... 1819 Dawe, Helen R...... 460 Costanzo, Margaret ...... 685 D’Angelo, Maximilliano A...... 1257 Dawes, Adriana ...... 26 Costello, Joseph ...... 481 d’Avigdor, William H...... 1084 Dawicki-McKenna, Jennine M...... 747, 1687 Costigliola, Nancy ...... 1012 D’Avino, Pier Paolo ...... 2205 Dawn, Amrita ...... 497 Costin, Adam J...... 2422 D’Epiro, Talyta T. S...... 513 Dayel, Mark J...... 484 Cote, Francine ...... 2022 D’Souza, Ryan S...... 951 de Beco, Simon ...... 360 Cote, Graham P...... 2320 D’Souza-Schorey, Crislyn ...... 1874, 269, 559 De Camilli, Pietro ...... 4, 829, 1111, 1140, 2094, 2404 Cotner, Sehoya H...... 1749 D`Silva, Sonia ...... 758 de Curtis, Ivan ...... 1274 Cotton, Sean ...... 718 D’Angelo, Giovanni ...... 825 de Figueiredo, Paul ...... 1363 Coulombe, Pierre A...... 2355, 42 da F. Costa, Luciano ...... 2423 de Jesus Perez, Vinicio A...... 1478 Counihan, Natalie A...... 538 Dabas, Geetanjali ...... 1977 De Jesus-Rojas, Wilfredo ...... 1981 Courty, Sebastien ...... 1611 Dacks, Joel B...... 1619 de Jong, Ton ...... 454 Couve, Andres ...... 773 Dadke, Disha ...... 1812 de Koning, Pieter J. A...... 550 Covassin-Barberis, Laurence ...... 1601 Dagley, Michael ...... 1624 De La Mota-Peynado, Alina ...... 1344 Cowan, Ann E...... 796, 918, 1753, 1943 Dahl, Kris N...... 202 De Lozanne, Arturo ...... 2222 Cowan, Colleen ...... 1359, 1546 Dahle, Oyvind ...... 1055 De Luca, Jennifer ...... 1428 Cowell, Mackenzie L...... 1741 Dahms, Nancy M...... 288 De Matteis, Maria Antonietta ...... 825 Cox, Dianne ...... 22, 434, 436 Dai, Ping ...... 1558 De Souza, Colin P...... 622 Cox, Elisabeth A...... 1016 Dal Farra, Claude ...... 1066, 1852, 2167, 76 De Vitis, Stefania ...... 173 Cox, Katie ...... 1313 Daley, George ...... 1303 Deaconescu, Alexandra M...... 2392 Cox, Michael E...... 1473 Dall’Armi, Claudia ...... 1092 Deak, Peter ...... 2205 Coyle, Rebecca ...... 886 Dallapiazza, Robert ...... 1546 Dean, Jurrien ...... 2021 Coyne, Carolyn ...... 539 Dalle, Stéphane ...... 1130 Deane, Charlotte M...... 748, 767 Cracium, Gheorghe ...... 1153 Dallon, John ...... 1790 Deans, Tara L...... 105 Craig, Elizabeth ...... 53 Damen, J. Mirjam A...... 550 Deasy, Bridget M...... 93, 216, 231, 1174 Craig, R...... 720 Dammermann, Alexander ...... 1432, 1491 DebBurman, Shubhik ...... 1892, 1894 Craig, Susan W...... 1784 Damuth, Emily ...... 629 Debeb, Bisrat G...... 212 Cram, Erin J...... 2262 Daniels, Brian R...... 1047 DeBiase, P J...... 1764 Cramer, Louise ...... 1613 Daniels, Mathew P...... 733 Debnath, Gargi ...... 348, 349, 350, 595 Cravatt, Benjamin F...... 2387 Danilchik, Michael V...... 2248 DeCelle, Kristen ...... 1741 Creancier, Laurent ...... 1435 Daniotti, Jose L...... 1081 Decker, Mark D...... 1749 Creed, Sarah ...... 442 Danner, Robert L...... 1845 DeCoste, Christina ...... 2447 Cremer, Marion ...... 36 Danuser, Gaudenz ...... 470, 1096, 1496, 1501, 1633, Decostre, Valerie ...... 560 Cremer, Thomas ...... 36 2235, 2298, 2379 Deeb, Faten ...... 131 Cremo, Christine ...... 391 Daquinag, A. C...... 406, 408, 1005 Deforest Hauser, Cindy ...... 83 Cremona, Ottavio ...... 2404 Darmon, Michèle ...... 777 Degoutin, Joffrey ...... 613 Creswell, Karen ...... 617 Dartt, Darlene A...... 82 Deguchi, Takashi ...... 1476 Crevenna, Alvaro H...... 2063, 443, 96 Darvish, Daniel ...... 518, 520 DeHaven, Wayne I...... 1131, 1132 Cribbs, J. T...... 1278, 1279 Das, Mita ...... 590 Deinhardt, Katrin ...... 1271, 2128 Crisp, Matthew ...... 1494 Das, Shamie ...... 916 Deininger, Katrin M...... 1261 Critchley, David R...... 2340 Das, Suman R...... 533 DeInnocentes, Patricia ...... 1534 Crittenden, John C...... 85 daSilva, Luis L...... 826 Dejan, Bursac´ ...... 1624 Croall, Dorothy E...... 98 Dassenko, David ...... 948 DeJesus, Michelle A...... 846 Crombie, Duncan ...... 1189 Datta, Kaustuv ...... 1957 Dejgaard, Kurt ...... 1991 Crouch, Elizabeth ...... 116 Datta, Kasturi ...... 598 Dejgaard, Selma Y...... 1991, 2112 Crowley, Jessica L...... 1006, 1007 Dauer, William T...... 1252 Dekkers, Martijn ...... 454 Cruz, Melisa ...... 1918 Daum, John ...... 1448 del Álamo, Juan C...... 419 Cruz López, Miguel ...... 440 Dave’, Rahul ...... 2338 del Campo, Jacob J...... 249 Csortos, Csilla ...... 1834 Davern, Timothy J...... 2354 Del Nery, Elaine ...... 1728 Cubano, Luis A...... 1344 Davey, Angel M...... 2068 Del Rosario, Brian C...... 2411 Cucchiarelli, Valeria ...... 2335 Davey, Michael ...... 827 Dela Cruz, Mark J. L...... 398 Cuervo, Laura ...... 1165 David, Karine ...... 1595 Delacour, Delphine ...... 2123 Cui, Bianxiao ...... 1880 Davids, Barbara ...... 1631 Delannoy, Mike ...... 2255 Cui, Ping ...... 1701 Davidson, Ben ...... 597, 1875 Delaunay, Jean-Louis ...... 2119 Cui, ShanShan ...... 2083 Davidson, Howard W...... 1151 Delautier, Danièle ...... 2119 Cukierman, Edna ...... 1573 Davidson, Kimberly G. V...... 910 Delaval, Benedicte ...... 1429, 1601 Culbertson, Christopher T...... 1193 Davidson, Lance A...... 311, 2024, 2032, 2033 Delay, Rona J...... 783 Cullender, Tyler C...... 2157 Davis, Amanda J...... 1563 Delmotte, Philippe ...... 452 Cummings, Patrick ...... 1755 Davis, Cassia D...... 2159 Delorme, Elizabeth B...... 275 Curi, Marco A. F...... 71 Davis, Cynthia R...... 632 DeLuca, Jennifer G...... 1499, 2236 227 AUTHOR INDEX The American Society for Cell Biology 47th Annual Meeting December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

DeLuca, Steve ...... 1494 Dieckmann, Carol L...... 1280 Doughman, Renee ...... 43 DeMaio, Antonio ...... 1841 Diener, Dennis R...... 14, 990 Douville, Josette M...... 1903 DeMarco, Jean E...... 207 Diering, Graham H...... 2136 Dovas, Athanassios ...... 436 DeMartino, George N...... 1813 Dieterle, Monika ...... 1710 Dovidio, Nicholas ...... 1741 Dembo, Micah ...... 1020, 1421, 1803, 2324 Dietrich, Kristen A...... 391 Dow, Julian ...... 191 Demczko, Matthew M...... 957 Diez, Gerold ...... 939, 1713 Dowd, Susan R...... 1064 Demczuk, Agnieszka ...... 143 Dighe, Shubha ...... 429 Dowler, Thomas R...... 1481 Demir, Özlem ...... 2299 Dillies, Clément ...... 1297 Downing, Kenneth H...... 391 Demmers, Jeroen ...... 20 Dilworth, David J...... 1965 Doxsey, Stephen J...... 1429, 1601 Denehy, Kevin M...... 957 DiMasi, Elaine ...... 880 Doye, Valérie ...... 1547 Deng, Glenn Y...... 576 Dimitrijevich, Dan S...... 80 Doyle, Andrew D...... 1407 Deng, Huai ...... 109, 2407 DiNardo, Stephen ...... 2319 Doyon, Genevieve ...... 1223 Deng, Hui ...... 1116 Ding, Wei ...... 2142 Doyonnas, Regis ...... 2452 Deng, Jie ...... 842 Ding, Xia ...... 1116, 1325, 1535 Dráber, Pavel ...... 2337 Deng, Luqin ...... 282 Ding, Xu ...... 716 Dráberová, Eduarda ...... 2337 Deng, Wu-Min ...... 1049, 2147 Ding, Yun ...... 651 Dranishnikov, Dmitri A...... 476 Deng, Zhihui ...... 160 Dinkova-Kostova, Albena T...... 42 Dravis, Christopher ...... 668 Denis, Maxime ...... 1009 Diplas, Bill ...... 416 Drechsler, Hauke ...... 498 Denner, Larry ...... 242 Discher, Dennis E...... 243, 312, 316, 1000, Dresser, Michael ...... 1642 Denning, Mitchell ...... 2356 1251, 1389, 1590, 2311 Drubin, David ...... 8, 1645 Dennis, James W...... 262 Dischinger, Sandra ...... 2246 Drummond, Meghan C...... 1709 Dentler, William ...... 989 Dislich, Bastian ...... 1104 Du, Jian ...... 2233, 2237 Denton, Christopher P...... 1824 Distefano, Gianfranco ...... 1819 Du, Xiaoping ...... 1804 DePaoli, Vania ...... 832 Ditlev, Jonathan ...... 474 Du, Xiulian ...... 243 DePianto, Daryle J...... 42, 2355 Divi, Srikanth ...... 664, 2255 Du, Zhaopeng ...... 1694 Der, Channing J...... 43 DiVito, Melinda M...... 956 Dubash, Adi D...... 2171 Derby, Merran ...... 1995 Dixit, Amruta ...... 2212 Dubendorff, John ...... 1918 Deresa, Lee ...... 1524 Dixit, Ram ...... 839, 1659 Dubey, Maya ...... 2341 Deretic, Dusanka D...... 2079 Dixon, Richard D. S...... 481 Dubowski, Theresa ...... 90 Dergunova, Lyudmila V...... 1664 Dixon, Wendy J...... 162 Ducat, Dan ...... 1436 Deriy, L...... 1842 Do, Duc P...... 120, 1917 Dufour, Sylvie ...... 1480 Derksen, D. R...... 2149 Do, Kee Hun ...... 421, 603 Duggan, Joan M...... 580 Dernburg, Abby F...... 1641 Do, Sun-hee ...... 1399, 2043, 2044, 2176 Duleh, Steve ...... 931 DeRosa, Adam M...... 1123 Dobrenis, Kostantin ...... 1897 Dultz, Elisa ...... 1547 Desai, Arshad ...... 992, 1432, 1487, 1491, Dobrin, Radu ...... 2447 Dulyaninova, Natalya G...... 1484, 1485 1499, 1645, 2251, 2254 Dodson, Matthew B...... 324, 1070 Dumas, Marc ...... 1222 Desai, Bhavik ...... 1583 Dodt, Hans-Ulrich ...... 1261 Dumbauld, David W...... 1784 Desai, Bhushan V...... 369 Doeppler, Heike ...... 902 Dunbar, David A...... 1168 Desai, Mukund ...... 202 Doering, Tamara L...... 1800 Dunbar, Maureen E...... 1168, 1169 Desai, Sonal ...... 341 Dogterom, Marileen ...... 19, 747, 1452, 1453, 1455 Duncan, Mara C...... 1980 Deschenes, Robert J...... 2138 Dohr, Gottfried ...... 1219, 1907 Dunham, Elizabeth ...... 577 DeSimone, Douglas W...... 311, 815, 1075 Doi, Naoko ...... 721 Dunlap, Jay C...... 1593 Desposito, Franklin ...... 246 Doi, Toshio ...... 524 Dunn, Teresa M...... 1135, 1136, 1374 Desrosiers, Ronald ...... 534 Dokudovskaya, Svetlana ...... 1626 Dunworth, William ...... 342 DeStefano, David ...... 199 Dolezal, Pavel ...... 1624 Duong, Myhanh ...... 1616 Deutschbauer, Adam M...... 57 Dolmetsch, Ricardo ...... 2399 Dupree, Jeff ...... 782 Devaraneni, Prasanna K...... 52 Dominguez, Alejandro ...... 1182 Duran, Josefi na ...... 535 Devgan, Vikram ...... 104 Dominguez, Roberto ...... 486, 488 Durand-Schneider, Anne-Marie ...... 2119 Devlin, Karl ...... 1161 Domke, Julia ...... 1198 Durcan, Thomas M...... 2256 Devos, Damien P...... 1618, 1626 Domloge, Nouha ...... 76, 1066, 1852, 2167 Dustin, Michael L...... 892 Devreotes, Peter N...... 414, 415, 416, 664, 1531 Domnitz, Sarah ...... 746 Duszynski, Jerzy ...... 515 Dewar, Brian J...... 1937 Dompierre, Jim ...... 1509 Dutra, Fernando P...... 1322 DeWitt, David ...... 704 Donahue, Renee N...... 1365, 2187 Dutt, Kamla ...... 1831 Dhanasekaran, Saravana ...... 141 Donaldson, John C...... 2139 Dutta, Anindya ...... 1242 Dharmawardhane, Suranganie ...... 1344 Donaldson, Julie G...... 284, 304, 2090 Duven, Jennifer ...... 1359 Di Campli, Antonella ...... 825 Donaldson, Mitzi ...... 555 Duvernay, Matthew ...... 285 Di Carlo, Andrea L...... 1832 Donati, Robert J...... 2435 Dveskler, Gabriela S...... 2026 Di Cunto, Ferdinando ...... 654, 1272 Donato, Rosario ...... 2196 Dye, Natalie A...... 848 Di Jeso, Bruno ...... 173 Dong, Chunmin ...... 2116 Dym, Martin ...... 199, 211, 236, 1556, 2202 Di Paolo, Aurelie ...... 1435 Dong, Ming ...... 1726 Dzamba, Bette ...... 311, 815 Di Paolo, Gilbert ...... 1092 Dorfman, Julia ...... 1962 Dzubay, J...... 1842 Di Pentima, Alessio ...... 2117 Dörken, Bernd ...... 557 Di Tullio, Giuseppe ...... 825 Dorn, Jonas F...... 1496, 1501, 2235 E Dias, F. A...... 1323 Dorovkov, Maxim V...... 1699 Ealy, Alan D...... 2016 Dias, Viviane M...... 625 Dorr, Rachel E...... 1691 Eaton, Suzanne ...... 1612 Diaz, Begoña ...... 2139 Dorrington, Mariana ...... 2109 Ebbing, Bettina ...... 1703 Diaz, Jheimmy ...... 996 Dorsten, Joy N...... 195 Ebens, Allen ...... 1358 Diaz, Juan C...... 1886 Dortland, Bjorn ...... 48 Ebersbach, Gitte ...... 855 Dickey, Burton F...... 264, 1336 Dose, Andrea ...... 1693 Eckdahl, Todd T...... 1741 Dickinson, Mary ...... 705 Dothager, Matthew ...... 113 Ecker, Joseph ...... 1630 Dictenberg, Jason B...... 1263 Dotti, Carlos ...... 1272 Edelman, Elazer ...... 873 228 The American Society for Cell Biology 47th Annual Meeting AUTHOR INDEX December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

Eder, Matthias ...... 1261 Engler, Adam J...... 206, 312, 1389 Farfán, Pamela ...... 2101 Edgerton, Heather D...... 627 Enikolopov, Grigori ...... 239 Farhadi-Far, Reza ...... 1612 Edidin, Michael ...... 1137, 2115, 2429 Enns, Caroline A...... 516 Farman, Mark ...... 1543 Edmondson, Rick ...... 2057 Enomoto, Masahiro ...... 1479 Farmen, Sara L...... 463 Edwards, Jonathan S...... 1914 Enomoto-Iwamoto, Motomi ...... 1310 Farr, Glen A...... 2076 Edwards, T. Matthew ...... 818 Eoff, Ullysses A...... 547 Farrar, Michael A...... 547 Effantin, Gregory ...... 1108 Epple-Farmer, Jessica ...... 212 Fasshauer, Dirk ...... 1620 Effl er, Janet C...... 1635, 2255 Eran, Henry ...... 1356 Fath, Thomas ...... 936, 2288 Efi menko, Evgeni ...... 454, 465 Erb, Teresa M...... 202 Faundez, Victor ...... 1982 Efi mov, Andrey ...... 709 Erbacher, Patrick ...... 1200 Faure, Robert ...... 91 Efremov, Artem ...... 1645 Ercan, Sevinc ...... 1487 Faure-Andre, Gabrielle ...... 996 Egea, Gustavo ...... 2104 Erdmann, Kai S...... 1111, 2094 Faust, Nicole ...... 1198 Egeblad, Mikala ...... 546 Erickson, Ann H...... 1983 Fava, Eugenio ...... 1984 Egelhoff, Thomas T...... 660, 2320, 2323, 2325, 2326 Erickson, Elizabeth S...... 13 Favard, Cyril ...... 355 Egleston, Brian L...... 1573 Erickson, Harold P...... 1464, 1465, 1794, 2332, 2414 Fawcett, James P...... 499 Eguma, Ayaka ...... 158 Ericson, Vivian ...... 374 Fearon, Paula ...... 624 Ehlers, Michael D...... 49 Erikson, Raymond ...... 649 Feeser, Elizabeth A...... 817 Ehrlich, H. Paul ...... 914, 1783, 1790 Eriksson, Peter S...... 39 Feinstein, Stuart C...... 1449, 1463 Ehrman, Sheryl H...... 1938 Eriksson, Ulf ...... 786 Feinstein, Timothy N...... 2003 Eiko, Yoshimura ...... 394 Erman, Aysegul ...... 1991 Feldman, Jessica L...... 984, 985, 1426, 1427 Eipper, Betty A...... 1088 Eroglu, Cagla ...... 2399 Felix, Marie-Anne A...... 795 Eisenberg, Evan ...... 1101 Esaki, Masatoshi ...... 2110 Fell, Brennen ...... 802 Eisenstein, Richard S...... 516 Escobar, Elsa ...... 2200 Felsenfeld, Gary ...... 819 Eisuke, Nishida ...... 652 Eshaghi, Majid ...... 2150 Felsher, Dean ...... 1205 El-Husseini, Alaa ...... 964 Esham, Micheal ...... 730 Felthauser, Alex ...... 174 El-Jouni, Wassim ...... 2102 Esk, Christopher ...... 2011 Feng, Wei ...... 1163 El-Samad, Hana ...... 1600 Eskew, Jeff D...... 722 Feng, Wenpo ...... 594 Elam, Candice A...... 976 Esmail, Muneer A...... 2082 Feng, Ying ...... 1009 Elde, Nels C...... 541 Espeut, Julien ...... 2241 Feng, Yanming ...... 2137 Eleftheriou, Lydia ...... 175 Essex, Anthony W...... 1491 Feng, Yuanyi ...... 241 Elgin, Sarah C. R...... 113, 1743 Essner, Jeffrey ...... 913 Fenteany, G...... 2270 Elias, Gustavo A...... 1963 Estes, Kathleen A...... 1076 Fenyvesi, Ferenc ...... 2073 Elias, Kathleen A...... 731 Etienne-Manneville, Sandrine ...... 359 Féréol, Sophie ...... 2281 Elias, Maria C...... 222 Ettinger, Audrey J...... 244 Ferguson, Matthew L...... 1089 Eliceiri, Kevin W...... 1520 Evans, Angela M...... 1063 Ferguson, Shawn M...... 2404 Elisseeff, Jennifer ...... 377 Evans, Irene M...... 146 Fernandez-Bueno, Carlos ...... 199 Elleder, Milan ...... 517 Evans, Mark A...... 504 Fernandez-Ulibarri, Ines ...... 2104 Ellenberg, Jan ...... 1547 Everhart, Lindsay ...... 617 Ferrari, Michael B...... 722, 725 Ellingboe, Jesse ...... 175 Ewald, Andrew J...... 546, 1616 Ferreira, Ana Inês ...... 1423 Elliot, Gene ...... 2031 Ewald, Katherine ...... 1313 Ferreri, Deana M...... 365 Elliott, David A...... 1317 Eyer, Joel ...... 2349 Ferrier, Andrew R...... 1072 Elliott, James M...... 1358 Eyers, Patrick A...... 2221 Fesquet, Didier ...... 2241 Elliott, John T...... 310, 1173, 1572, 1797 Eyster, Craig A...... 2090 Fey, Petra ...... 2377 Ellis, Beverly A...... 1340 Ezura, Yoichi ...... 1851 Fidock, David ...... 1622 Ellis, Mark A...... 2064 Fiedler, Dorothea ...... 1632 Ellory, J. Clive ...... 592 F Field, Christine ...... 654 Elloul, Sivan ...... 1875 Fabian, Lacramioara ...... 982 Field, Mark C...... 1623 Elmendorf, Heidi G...... 1317, 1318 Fabry, Ben ...... 432, 876, 1011, 1466, 1713, 1802 Fields, Erica ...... 2321 Elshourbagy, Nabil ...... 99 Fadey, Olugbeminiyi ...... 1349 Fields, Ian ...... 2129 Elson, Elliot ...... 1716 Faessler, Reinhard ...... 921 Fields, Melanie C...... 1737 Elston, Timothy C...... 702, 1012 Fagarasanu, Andrei D...... 695, 827, 1625 Figueiredo, Ana ...... 1079 Ely, Bert ...... 1285 Fagerstrom, Carey ...... 661, 1513 Figueroa, Maria E...... 1603 Elzie, Carrie ...... 1672 Fahrenkrog, Birthe ...... 842, 1255, 1953 Figueroa-Clarevega, Alejandra ...... 113 Emans, Neil ...... 101 Faijerson, Jonas ...... 39 Filippi, Bruno G. H...... 1086 Emanuele, Michael J...... 2230, 2234 Faix, Jan ...... 418 Filmer, Richard P...... 846 Emerit, Michel B...... 777 Fajardo, Carolina ...... 528 Finger, Fern P...... 1244, 2285 Emr, Scott D...... 830, 1112 Falguières, Thomas ...... 1974 Finkelstein, Erik I...... 1456 Emre, Nil ...... 1189 Falk, Matthias M...... 919, 920 Finlay, B. B...... 1335 Ems-McClung, Stephanie ...... 1723 Fall, Bruce A...... 1749 Finney, C. A...... 2064 Encinas, Juan M...... 239 Fallen, Shannon ...... 236 Firtel, Richard A...... 419 Enderling, Heiko ...... 308 Falnikar, Aditi ...... 2295 Fischer, Elizabeth ...... 32 Endow, Sharyn A...... 1444 Famulski, Jakub K...... 2238 Fischer, Robert S...... 372 Eng, Edward W. Y...... 1331 Fan, Alice ...... 1205 Fischer, Thierry ...... 291 Engebrecht, JoAnne ...... 252 Fan, Jia-Rong ...... 1351, 1537 Fisher, Charles I...... 478 Engel, Andrew G...... 781 Fan, Xiaoxue ...... 925 Fisher, Edward A...... 1141, 1158 Engel, Benjamin D...... 986 Fang, Shunming ...... 837, 1093 Fisher, Katherine H...... 748, 767 Engel, Joanne ...... 27 Fang, Xu ...... 584 Fisher, Michael E...... 1416 Engel, P...... 720 Fang, Xiao-Dong ...... 668 Fisher, Robert P...... 11 Engel, Ulrike ...... 300 Fang, Yi ...... 798 Fisher, Shannon ...... 1813 Engels, Boris ...... 557 Fang, Zhiyou ...... 1007 Fiske, Michael ...... 1892 Engelsma, Dieuwke ...... 717 Farber, Steven A...... 1300, 1302 Fix, Marina ...... 263 229 AUTHOR INDEX The American Society for Cell Biology 47th Annual Meeting December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

Flavell, Richard A...... 1608, 2404 Frey, Margo T...... 1196 Gajewski, Christine ...... 299 Fleming, Steve B...... 2163 Frey, Tiffany A...... 1841 Gal, Susannah ...... 1521 Fleschner, Charles R...... 1138 Friderici, Karen A...... 1391, 1709 Galat, Vassilyi ...... 212 Flessner, Lauren B. V...... 1083 Friede, Kevin ...... 948 Galbraith, Catherine ...... 1412, 1418 Fletcher, Daniel A...... 424, 425, 1316, 1682 Friedl, Andreas ...... 2416 Galbraith, James ...... 1412, 1418 Fletcher, Maryann D...... 272 Friedland, Julie ...... 323, 61 Galdeen, Shawn A...... 959 Fletcher, Paul L...... 272 Friedlander, Jonathan ...... 1611 Galdieri, Luciano ...... 143 Flevaris, Panagiotis ...... 1804 Friedman, Thomas B...... 1224, 958 Galea, Janette ...... 2422 Fligny, Cécile ...... 2022 Friend, Janice E...... 2247 Galeano, Belinda ...... 520 Flinders, Jeremy ...... 856 Frigault, Matthew ...... 1776 Galindo, Cristi L...... 549 Flinn, Rory J...... 609 Frisch, Steven M...... 1772 Galinska-Rakoczy, A...... 720 Flitney, F. W...... 1637 Frock, Richard L...... 1063 Galkina, Svetlana I...... 893 Floetenmeyer, Matthias ...... 2422 Froelich, Christopher J...... 550 Gall, Joseph G...... 134, 1650 Flom, Gary ...... 54 Frolenkov, Gregory I...... 958 Gallager, Patricia J...... 2193 Florens, Laurence ...... 2412 Fromm, Larry ...... 1259 Gallagher, Shannon M...... 2267 Florent, Jean-Claude ...... 831 Frommelt, Jon L...... 1396 Gallant, Cynthia ...... 1021, 736 Flores-Benitez, David ...... 871 Frost, Jeffrey A...... 2171 Gallardo, Gilbert ...... 1264 Flores-Rodriguez, Neftali ...... 1727 Frydman, Judith ...... 57 Galli, Thierry ...... 1262 Florin, Ernst-Ludwig ...... 1460 Fu, Chuanhai ...... 18, 747, 1488 Gallicano, G. I...... 199, 204, 235, 1306 Florindo, Claudia ...... 2209 Fu, QiangWei ...... 1307 Gallicchio, Marisa A...... 522 Floros, Joanna ...... 1333 Fu, Yi-Chi ...... 1833 Gallik, Stephen ...... 1149 Flotho, Annette ...... 717 Fu, Yifan ...... 1893 Gallo, Gianluca ...... 1276, 2287, 2292, 2296 Flynn, Kevin C...... 1051 Fuerst, John ...... 1617 Gallo, Gino ...... 1582 Flynn, Patrick G...... 2327 Fujibayashi, Akemi ...... 1585 Gallop, Jennifer L...... 1041 Fodil, Redwan ...... 2281 Fujieda, Takayuki ...... 1197 Gallucci, Stefania ...... 1008 Foley, Emily A...... 1647 Fujimaki, Kayo ...... 2015 Galmes, Romain ...... 2071 Foley, Jessica ...... 563 Fujimoto, Masafumi ...... 508 Galvin, Jason W...... 1765 Foley, Theodore T...... 914 Fujimoto, Zui ...... 395 Gama, Patricia ...... 513, 71 Folker, Eric S...... 38, 757 Fujimura, Ken ...... 132 Gama-de-Souza, Letícia N...... 327 Follit, John A...... 451, 453 Fujita, Satoshi ...... 788, 1930 Gammoh, Noor ...... 2131 Fölsch, Heike ...... 2129 Fujita, Yoshinobu ...... 712 Gan, Lu ...... 2421 Fong, Loren G...... 1254 Fujita-Yoshigaki, Junko ...... 81 Gan, Zhuo ...... 2424 Footen, Marc ...... 107 Fujiwara, Ikuko ...... 965 Gandhi, Meghal ...... 1013 Ford, Elisabeth ...... 186 Fujiwara, Keigi ...... 1552 Gandhi, Manoj ...... 114 Forero, María ...... 528 Fujiwara, Sumire ...... 1595 Gandre, Shilpa S...... 804 Formstecher, Etienne ...... 1547 Fukaguchi, Kiyomitsu ...... 1585 Gangopadhyay, Samudra S...... 736 Fornerod, Maarten ...... 717 Fukata, Masaki ...... 1080 Gannon, Patrick J...... 697 Forraz, Nico ...... 242 Fukata, Yuko ...... 1080 Gao, Chunlei ...... 988 Forscher, Paul ...... 2298 Fukuda, Taku ...... 781 Gao, Hongjuan ...... 134 Forsyth, Patricia ...... 1265 Fukumoto, Yuri ...... 352 Gao, Lin ...... 232, 233 Fort, Patrice E...... 100 Fukunaga, Kohji ...... 776 Gao, Xiang-dong ...... 1039 Fóscolo, Mabel ...... 769 Fuller, Margaret T...... 226 Gao, Xinjiao ...... 1116 Foshay, Kara M...... 204, 235 Fumiko, Toyoshima ...... 652 Gao, Yan ...... 1474 Fowler, Brent ...... 337 Funabiki, Hironori ...... 115, 2223 Gao, Zhizhen ...... 1430 Fowler, Velia M...... 728 Funahashi, Yasuhiro ...... 775 Garbay, Christiane ...... 1480 Fowlks, Edison R...... 1741 Funakoshi, Shinsuke ...... 1217 Garbi, Corrado ...... 173 Fox, Ann ...... 917 Furber, Levi A...... 857, 2191 Garcés, Jonathan ...... 1689 Fox, Laura A...... 976 Furstenau, Dana K...... 398 Garcia Lopez, Maria A...... 291 Fox, Randall J...... 1287 Furukawa, Kazuhiro ...... 1944 Garcia, Andres J...... 1784, 1807 Fox, Thomas D...... 1288 Furukawa, Katsuko ...... 97 Garcia, Gene L...... 412 Fraisier, Vincent ...... 831 Furuno, Tadahide ...... 305, 611 Garcia, Lisbeth L...... 1265 Fraley, Sara ...... 823 Furuno, Yumi ...... 1811 García, María de los Angeles ...... 780, 1139 Francis, Richard J. B...... 1124 Furusawa, Takashi ...... 157, 70 Garcia, Tzintzuni ...... 726, 1927, 1928 Franck, Andrew D...... 747, 755, 1445, 1488, 1517 Fushikida, Kuni ...... 1197 Garcia Leon, Maria J...... 291 Franco, Martha ...... 871 Futami, Junichiro ...... 1366, 2197 Garcia-Alonso, Angel ...... 748 Frank, Deborah J...... 1695 Fuzisaki, Tatiana T...... 1395 Garcia-Garcia, Erick ...... 198 Frank, Stuart ...... 282 Garcia-Mata, Rafael ...... 2171 Frankfurter, Anthony ...... 2331 G Gardel, Margaret L...... 372, 1633, 1702, 1715 Frankland, Sarah ...... 1315 Gaban, Adam ...... 1153 Gardner, Melissa K...... 1508 Franklin, Jeffrey ...... 2012 Gabillet, Julie ...... 2119 Gardner, Thomas W...... 100 Franson, Kristen E...... 416 Gable, Ken ...... 1135, 1136 Garg, Pallavi ...... 338, 77 Franzini-Armstrong, Clara ...... 668 Gabric, Kathleen ...... 1741 Garnacho, Carmen ...... 299 Fraser, Scott E...... 2428 Gabrielson, Edward ...... 1864 Garner, Ethan C...... 849 Freeman, Michelle C...... 766 Gachet, Yannick ...... 1282 Garrett, Sarah C...... 1486 Fregien, Nevis L...... 2066 Gaertig, Jacek ...... 2396 Garrido-Lecca, Alfonso ...... 1363 Freitag, Dieter ...... 1011 Gagnon, AnneMarie ...... 602 Garvalov, Boyan ...... 1051 Freitas, Vanessa M...... 1357, 326, 327 Gagnon-Kugler, Thérèse ...... 816 Gary, Todd ...... 1348 French, Barbara A...... 823, 1973, 2342 Gahl, William A...... 518, 520 Gascard, Philippe ...... 280, 349 French, Samuel W...... 823, 1973, 2342 Gai, Marta ...... 654 Gasiorowski, Joshua Z...... 315, 1195 Freudzon, Marina ...... 918 Gaillard, Anne R...... 977 Gassen, Berthold ...... 427 Frey, Erwin ...... 2372 Gajdos, Gabriella B...... 531, 532 Gassmann, Reto ...... 1487 230 The American Society for Cell Biology 47th Annual Meeting AUTHOR INDEX December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

Gathman, Allen C...... 638 Giansanti, Maria Grazia ...... 2250 González, Alfonso ...... 2126 Gatlin, Jesse C...... 1646 Gidalevitz, Tali ...... 177 Gonzalez, Claudia ...... 1918 Gatti, Maurizio ...... 2250 Giddings, Thomas H...... 623 Gonzalez-Billault, Christian ...... 760 Gatti, Sabrina ...... 1710 Gierke, Sarah ...... 753 Gonzalez-Mariscal, Lorenza ...... 865 Gaubatz, Stefan ...... 2040 Gil, Sonia ...... 214 Gooch, Van ...... 1593 Gaul, Ulrike ...... 78 Gilbert, Penney M...... 317 Goode, Bruce L. ...838, 1013, 1015, 1030, 1450, 2392 Gault, William ...... 191 Giles, Lisa M...... 1888 Goode, Jennifer ...... 213 Gaur, Surabhi ...... 1118 Gillette, Jennifer M...... 1183, 2448 Goodell, Margaret A...... 1809 Gaus, Katharina ...... 831 Gilligan, Emer ...... 607 Goodman, Benjamin ...... 1199 Gaussen, Amaury ...... 2241 Gillin, Frances D...... 1631 Goodman, Joel M...... 512 Gauthier-Rouvière, Cécile ...... 355, 362 Gimeno, Alejandro B...... 2111 Goodson, Holly V...... 757 Gautier, Philippe ...... 1301 Gioeli, Dan ...... 1876 Goodyer, Cynthia G...... 1369 Gavard, Julie ...... 63, 1902 Giovedi, Silvia ...... 2404 Goold, Lucy ...... 908 Gavin, Ray H...... 1689 Girard, Angelique ...... 2440 Goracke, Alissa ...... 175 Gaylord, Michelle R...... 1449 Girard, Kristine D...... 2255 Gorbacheva, Victoria ...... 1599 Gbegnon, Mawuse K...... 317 Girton, Jack ...... 109, 651, 2407 Gorbsky, Gary J...... 1448, 2151 Ge, Z...... 1180 Gitai, Zemer ...... 850 Gordon, David ...... 271 Gedikoglu, Gunduz ...... 1068 Glasgow, Eric ...... 1226 Gordon, Ineta ...... 779 Gee, Elaine ...... 8 Gleeson, Paul ...... 1995 Gordon, Jeff ...... 1582 Gee, K...... 1842 Glick, Benjamin S...... 1992, 2004, 2005, 2110 Gordon, Michael R...... 1741 Gehler, Scott ...... 1761, 2415 Glöckner, Gernot ...... 2377 Gordon-Weeks, Phillip ...... 21, 761 Geier, Susan J...... 1969 Glogauer, Michael ...... 1824 Gorelik, Anna ...... 44 Geiger, Kathrin ...... 1383 Glotzer, Michael ...... 17, 691, 2253 Gorski, Stanislaw ...... 116 Geiger, Jennifer A...... 87 Glover, David M...... 1423, 2205 Goshima, Gohta ...... 1488 Geimer, Stefan ...... 987, 1426, 1431 Glover, Sarah C...... 1871 Goss, John ...... 273 Geissler, Phillip ...... 1682 Glunde, Kristine ...... 1791 Gostic, William J...... 292 Gelfand, Vladimir I...... 699, 1735 Goda, Katalin ...... 2073 Goto, Kaoru ...... 1714 Geli, Maria Isabel ...... 1090 Godinez, Lucia ...... 685 Goto, Shinji ...... 283 Geller, Herbert M...... 1461 Godinho, Susana A...... 640 Gotoh, Nanami ...... 1694 Gemberling, Matthew ...... 1741 Godley, Lucy A...... 1603 Gotoh, Noriko ...... 2027 Geng, Fei ...... 371 Godsel, Lisa ...... 2356 Gotthardt, Daniel ...... 191 Geng, Song Song ...... 1921, 1923 Goeckeler, Jennifer L...... 1158 Gotthardt, Michael ...... 727, 734 Gennerich, Arne ...... 494 Goeres, Jacqueline D...... 16, 1972 Gould, Kathleen L...... 667, 2159 Genovesio, Auguste ...... 101 Goetz, Jacky ...... 1473 Gould, Stephen J...... 798 Gentalen, Erik T...... 1205 Goh, Jaclyn ...... 2422 Goulding, Morgan ...... 713 Georgakopoulou, Sofi a ...... 2345 Göhre, Vera ...... 29 Gouveia, Susana M...... 20, 48 George, Anna ...... 533 Goicoechea, Silvia M...... 1414 Gouzi, Jean Y...... 613 George, Lacy K...... 1512 Goins, L M...... 747 Govindarajan, Venkatesh ...... 1309 George, Sudeep P...... 949 Gokhale, Avanti ...... 975 Gowda, G A. Nagana ...... 523 Georges, P. C...... 1850 Goldberg, Alexander ...... 1065 Gower, William R...... 290 Gerace, Larry ...... 1392, 1957 Goldberg, Elysa ...... 511 Goyal, Amrita ...... 556 Geraldo, Sara ...... 21 Goldberg, Gary S...... 900, 995 Goyal, Gaurav ...... 802 Gerdes, Jantje M...... 1813 Goldberg, Martin ...... 1798 Grabner, Chad ...... 2402 Gerecht, Sharon ...... 1194 Goldblum, Simeon E...... 77, 338, 344, 2273 Grabowska, Dorota ...... 1565 Gerisch, Günther ...... 300 Golden, Andy ...... 1520 Grabski, Robert ...... 2085 Gerke, Volker ...... 1110 Golden, Jefferey ...... 1958 Graczyk, Beth ...... 1644 Gerlich, Daniel W...... 658 Goldenberg, Samuel ...... 1182 Gradilone, Sergio A...... 455, 456, 1393, 1816 Gerlitz, Gabi ...... 2265 Goldenring, James R...... 709, 1113, 2012, Graham, Megan L...... 1837 Germino, Gregory G...... 1819 2099, 2100, 2125, 2434 Gramatikoff, Kosi ...... 1370 Gerritsen, Hans C...... 1935 Goldman, Robert D...... 36, 841, 1255, Graner, Francois ...... 1611 Gersbach, Charles A...... 1784 1637, 1946, 1953, 2361 Grange, Robert W...... 2137 Gershwin, M. Eric ...... 2353 Goldman, Yale E...... 839 Grant, Barth D...... 828 Gerson, Adina ...... 385 Goldmann, Wolfgang H...... 876, 939, 1713, 1802 Grant, Gavin D...... 1545 Gerstein, Mark ...... 57 Goldsmith, Edie C...... 879 Grant, Philip ...... 600, 2350 Gersten, Merril ...... 1629 Goldstein, Bob ...... 358, 671, 901, 1046, 2263 Grant, Seth G...... 1311 Gertel, Yaron ...... 86 Goldstein, Bree ...... 72 Granzier, Henk ...... 727, 734 Gestaut, Daniel R...... 1445, 1517, 1644 Goldszmid, Romina ...... 525 Graves, Lee M...... 1937 Getz, Ashley ...... 1169 Golemis, Erica ...... 1471, 1812, 188 Graves-Deal, Ramona ...... 2012, 2142 Gevrey, Jean-Claude ...... 434, 436 Golestaneh, Nady-Celine ...... 199, 211, 236, 1556 Gray, Russell ...... 1153 Geyer, Pamela K...... 1248, 2360 Gomer, Richard ...... 185 Greco, Natalie J...... 1745 Geyer, Rory ...... 902, 1870 Gomes, Marta T...... 1322 Green, Ariel ...... 1666 Ghadiali, Samir ...... 950 Gomez, Guillermo A...... 1081 Green, Colin R...... 248, 908 Gharakhanian, Editte ...... 1985 Gomez-Ferreria, Maria A...... 1440 Green, Douglas R...... 807 Ghashghaei, Troy ...... 205 Gönczy, Pierre ...... 1441, 1519 Green, Eric M...... 2399 Gheber, Leah ...... 385 Gonda, Steve R...... 1193 Green, George R...... 120, 1917 Ghenoiu, Cristina ...... 115 Gondran, Catherine ...... 76 Green, Joffre A...... 1793 Ghosh, Chandra C...... 1862, 1867 Gonen, Tamir ...... 1445, 1517 Green, Kathleen J...... 369, 2356 Ghosh, Richik N...... 1933 Gong, Haixia ...... 1804 Green, Rebecca A...... 992, 2141 Ghosh, Shatadal ...... 933 Gong, Liang-Wei ...... 2404 Green, William ...... 1328 Ghosh-Roy, Anindya ...... 497 Gong, Ping ...... 77, 344 Greenan, Garrett ...... 631, 1516 Giacomello, Emiliana ...... 2065 Gong, Xiaohua ...... 911, 1123 Greenberg, Cynthia C...... 733 231 AUTHOR INDEX The American Society for Cell Biology 47th Annual Meeting December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

Greenberg, Jean ...... 30 Gunn, Priscilla ...... 1995 Halpin, Elizabeth S...... 2256, 643 Greenberg, James M...... 1906 Gunning, Peter W...... 441, 442, 936, 1676, 2288 Halter, Michael ...... 1173, 1797, 1941 Greenberg, Michael ...... 1698 Gunther, Ulrich ...... 218 Ham, Amy-Joan ...... 709, 2012 Greene, Dina N...... 1927 Guo, Chunqing ...... 1700 Hamaguchi, Michinari ...... 642 Greene, Lois ...... 1101 Guo, Jiayan ...... 2333 Hamasaki, Mayumi ...... 1479 Greenhalgh, Jenny ...... 1189 Guo, Jih-Huong ...... 582 Hamberger, Jason D...... 225 Greenwood, John ...... 504, 870 Guo, Lei ...... 161 Hamidi, Sayyed A...... 1835 Greenwood, Tammy M...... 621 Guo, Liang ...... 486 Hamill, Kevin J...... 1482 Greer, Peter A...... 1474, 1481 Guo, Qing ...... 787, 1377, 1378 Hamilton, Lanette R...... 1832 Gregg, Christopher ...... 1065 Guo, Shuangli ...... 133 Hammer, Daniel ...... 1421, 1803 Greggio, Elisa ...... 1381 Guo, Tong ...... 1065 Hammer, John A...... 696, 934 Gregor, Martin ...... 1778, 2363 Guo, Wei-hui ...... 1774 Hammer, Robert E...... 1439 Gregorio, Carol C...... 729 Guo, Wei ...... 266, 267 Hammond, Jennetta W...... 1733 Gregory, Brian ...... 1630 Guo, Xiaoxuan ...... 1333 Hammond, Stephanie ...... 170 Greif, Karen F...... 1277 Guo, Yusong ...... 2002 Hammonds-Odie, Latanya P...... 1073 Gremyachinskiy, Dmitri ...... 1408, 1937 Guo, Zhen ...... 1116, 1325 Hamon, Michel ...... 777 Gribar, Steven ...... 90 Gupta, Amarnath ...... 1631 Hamon, Melanie A...... 33 Griffi n, Kelly ...... 1733 Gupta, Dwijendra K...... 523, 1405 Hampoelz, Bernhard ...... 1954 Griffi n, Laura E...... 962 Gupta, Kamlesh K...... 757 Han, Gongshe ...... 1135, 1136 Griffi s, Eric R...... 657 Gupta, Mohan L...... 1719 Han, Haesun ...... 2242 Griffi th, Andrew J...... 958, 1134 Gupta, Rakesh K...... 1320 Han, In-oc ...... 1170 Grigorieff, Nikolaus ...... 2392 Gupta, Sita D...... 1136 Han, Jin-Kwan ...... 1043 Grigoriev, Ilya ...... 20, 708, 717 Gupte, Melanie ...... 1871 Han, Joo S...... 2231 Grigsby, Iwen F...... 1244 Gusarova, Viktoria ...... 1158 Han, Linqu ...... 1595 Gril, Brunilde ...... 1480 Gusella, Luca ...... 1830 Han, Min ...... 716 Grinnell, Frederick ...... 307 Gutierreze, Jose ...... 2412 Han, Seung-Ok ...... 1569 Grinstein, Sergio ...... 302, 706, 1082, 1976 Gutkind, J. Silvio ...... 63, 1902 Han, Sejin ...... 373 Grintsevich, Elena E...... 2370, 2375 Gutman, Orit ...... 2139 Han, Victor K...... 679 Grishchuk, Ekaterina L...... 1645, 2207, 2213 Guttman, Julian A...... 435, 1335 Han, Yong-Mahn ...... 201 Grishok, Alla ...... 2437 Guvakova, Marina A...... 398 Hanada, Kentaro ...... 89 Grivna, Shane ...... 2451 Guy, Clifford S...... 2017 Hanada, Shinichiro ...... 2348, 2354, 2365 Groben, Pamela ...... 596 Guzinska, Katarzyna ...... 143 Hanada, Toshihiko ...... 1724 Grodzinsky, Alan J...... 2413 Guzzo, Julie ...... 1078 Hance, Michael ...... 1857 Groen, Aaron C...... 1510, 1646 Gwack, Yousang ...... 553 Hancock, William O...... 393, 944, 1639 Groenendyk, Jody ...... 2034 Gyoneva, Stefka ...... 562 Hand, Arthur R...... 345, 501, 503 Grosheva, Inna ...... 507 Haney, Steve ...... 1375 Gross, John D...... 856 H Hanlon, Sean E...... 638 Grossel, Martha J...... 1538 Ha, Cam T...... 2026 Hanna, Matthew ...... 1210 Grossi, Alberto ...... 436 Ha, Hyunil ...... 1566 Hanna-Rose, Wendy ...... 196, 1058, 1076 Grossniklaus, Hans E...... 353 Ha, Junghoon ...... 1658 Hannon, Gregory J...... 2440 Grote, Eric ...... 890 Ha, Sang Hoon ...... 1549 Hannun, Yusuf ...... 825 Grote-Westrick, Christian ...... 1475 Ha, Tuanzhu ...... 692 Hanover, John ...... 1970, 859 Grothe, Claudia ...... 2282 Haapasalo, Hannu ...... 567 Hansen, Marc D. H...... 335, 337, 1023 Grove, Matthew P. C...... 1311 Haass, Christian ...... 1104 Hansen, Paula ...... 1182 Grubb, Barbara R...... 1825 Habermann, Bianca ...... 1984 Hansen, Wendy R...... 1316 Gruber, Charley ...... 1363 Habiel, David M...... 1158 Hansma, Helen ...... 1910 Gruenbaum, Yosef ...... 35 Habtezion, Aida ...... 1390 Hanssen, Eric ...... 1315 Gruenberg, Jean ...... 1974 Hackam, David J...... 90 Hao, Yi-heng ...... 187 Grumet, Martin ...... 1681 Hackl, Seija ...... 1151 Hao, Yi ...... 1971 Gruver, Jonathan S...... 428 Hackstad, Ted ...... 32 Hara, Mari ...... 328 Gryte, Kristofer ...... 246 Hadj-Slimane, R ...... 1480 Harada, Akihiro ...... 2124 Gu, Changkyu ...... 1095 Hager, Gordon L...... 2410 Harada, Kazutsune ...... 574 Gualdoni, Sara ...... 1274 Haglund, Cat M...... 31 Harada, Masaru ...... 2348 Guan, Jun-Lin ...... 253 Hahm, Dae-hyun ...... 1186, 1187 Harada, Reiko ...... 2124 Guberman, Jonathan ...... 850 Hahn, Klaus M...... 402, 403, 1408, 1410, Haraguchi, Mitsuya ...... 776 Gucwa, Azad L...... 297 1411, 1486, 1914, 1937 Haraguchi, Tokuko ...... 1256, 1951 Guérin, Christophe ...... 1017, 1019 Haigh, Jody ...... 786 Hardeman, Edna C...... 1676 Guerra, Charles F...... 446 Haines, Thomas H...... 1293 Hardin, Jeff ...... 812, 1016 Guerrier, Sabrice ...... 43 Hainfeld, James ...... 1209, 1918 Haren, Laurence ...... 1435 Guerriero, Christopher J...... 2083 Haj, Alex ...... 1924 Harland, Richard M...... 794, 1042 Gueudry, Charles ...... 360 Haj-Ahmad, Yousef ...... 142, 1921, 1922, Harmon, Jeffrey M...... 1135, 1136, 1374 Guillemette, Shawna ...... 1799 1923, 1924, 1925 Harper, Dawn C...... 1981 Guillemot, François ...... 1509 Hajjar, Adeline M...... 1825 Harris, Abigail ...... 104 Guillen, Lalisse ...... 505 Hajjar, Kathy A...... 504 Harris, Elizabeth S...... 1034 Guillozet-Bongaarts, Angela ...... 1893 Hakanen, Janne ...... 1681 Harris, Kathryn P...... 333 Guimaraes, Geoff J...... 2236 Hall, Joseph C...... 904 Harris, Nathan J...... 331, 1355 Guizetti, Julien ...... 658 Hall, Kenton ...... 692 Harris-Hooker, Sandra ...... 1831 Gulyani, Akash ...... 1411, 1937 Hallen, Mark A...... 1444 Harrison, Benjamin D...... 2218 Gumbiner, Barry ...... 65 Hallett, Michael ...... 1627 Harrison, Rene E...... 952, 1331, 1849 Gumpert, Anna ...... 920 Hallett, Mark A...... 445, 923, 1815 Harrison, Stephen ...... 751 Gundersen, Gregg G...... 38, 499, 1252, 1450 Hallworth, Richard ...... 1292 Hart, Charles ...... 1995 232 The American Society for Cell Biology 47th Annual Meeting AUTHOR INDEX December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

Hart, Peter ...... 1350 Hendzel, Michael ...... 150 Hobbs, Ryan ...... 2356 Hartel, Steffen ...... 773 Heng, Justin K...... 2264 Hochstrasser, Mark ...... 1502 Hartig, Sean M...... 467, 2137 Henis, Yoav I...... 2139 Hodges, Robin R...... 82 Hartman, James ...... 1025 Henklein, Peter ...... 2126 Hodgson, Louis ...... 402, 403, 1410, 1411 Hartmann, Boris M...... 558 Hennessey, Todd M...... 1326 Hoe, Kwang-Lae ...... 2064 Hartmann, Dieter ...... 40 Hennet, Thierry ...... 1086 Hoeman, Kurt ...... 1193 Hartwick, Andrew T. E...... 910 Henschel, Robert ...... 1984 Hoenderop, Joost G. J...... 1110 Hartwig, John ...... 1095 Henson, John H...... 1419 Hoenger, Andreas ...... 745 Haruna, Kunitaka ...... 89 Henson, Lauren H...... 1419 Hoersch, Sebastian ...... 2437 Hasebe, Mitsuyasu ...... 2393 Hentrich, Christian ...... 383 Hoffman, Eric ...... 560 Hasezawa, Seiichiro ...... 2393 Heo, Jun-Young ...... 673, 674, 1560, 2155 Hoffman, Matthew ...... 378 Hashimoto, Yasuaki ...... 574 Her, Jung-Hyun ...... 1043 Hoffmann, Celine ...... 1710 Hashmi, Shahr ...... 622 Herant, Marc ...... 1020 Hoffmann, Ingrid ...... 619 Hassan, Mohammad Q...... 1220 Hergert, Polla ...... 645 Hofmann, Marie-Claude ...... 211, 1556, 2202 Hassoun, Amani T...... 1260 Herman, Jessica P...... 1534 Hogan, Deborah A...... 1343, 1586 Hatfi eld, William T...... 1741 Hermo, Louis ...... 1627 Hogenesch, John ...... 1598 Hatia, Sarah ...... 2022 Hermosilla, Tamara ...... 1810 Hoh, Jan H...... 1777 Hatler, Julia ...... 913 Hernandez, Catalina ...... 516 Hohenester, Erhard ...... 1795 Haucke, Volker ...... 1140, 2403 Hernandez, Mariana V...... 364 Holaska, James M...... 1253 Haugh, Jason ...... 420, 1550 Hernandez Roa, Jonatan ...... 647 Holicky, Eileen L...... 296 Haun, Shirley ...... 2057, 2102 Herndon, Carter A...... 1259 Holinger, Eric P...... 623 Hauri, Hans-Peter ...... 2105 Herrera, Magnolia ...... 1164 Hollenbeck, Peter J...... 710, 711, 2280, 2443 Hauschka, Stephen D...... 1063 Herrera-Esparza, R...... 784 Holloway, Beth ...... 724 Haussler, David ...... 2388 Herrera-Molina, Rodrigo ...... 1810 Hollway, Georgina E...... 1301 Hauswirth, William W...... 676 Herring, Matthew ...... 628 Holmbeck, Kenn ...... 378 Haviland, David B...... 1788 Herrler, Michael ...... 576 Holmes, Raquell M...... 1753, 796 Havivi, Nadav ...... 2322 Herrmann, Harald ...... 35, 841, 2339, 2345, 2358 Holmes, William B...... 730 Häweker, Heidrun ...... 29 Herron, Bruce J...... 80 Holmlund-Hampf, Jeanette ...... 567 Hawrysh, Andrea D...... 857, 2189, 2190, 2191 Hertel, Moritz ...... 1539 Holoweckyj, Nickolas ...... 596 Hayashi, Hisayoshi ...... 302 Hertweck, Maren ...... 1104 Holowka, David A. ..170, 552, 612, 1844, 2059, 2430 Hayashi, Jun-Ichi ...... 1890, 1898 Hertzberg, Elliot L...... 1897 Holt, Liam J...... 2217 Hayashi, Jyunko ...... 899 Hertzer, Kathleen M...... 1722 Holtackers, René ...... 1492 Hayashi, Mitsuko ...... 2404 Hesse, Shayla E...... 1338 Holtorf, Heidi L...... 1193 Hayashida, Tomoko ...... 1827 Hessle, Helena ...... 1905 Holvey-Bates, Elise G...... 244 Hayata, Tadayoshi ...... 1851 Hetzer, Martin W...... 1257, 1258 Holzbaur, Erika L. F...... 500, 839, 1659, Haydar, Tarik F...... 565 Heumann, Rolf ...... 1475 1660, 1887, 2091 Hayden, Melissa A...... 1308 Heuser, John E...... 2240 Holzwarth, George M...... 704 Hayes, David B...... 486, 488 Heussinger, Claus ...... 2372 Homan, Takashi ...... 2177 He, Bing ...... 266 Hewett, Jeffrey ...... 1376 Homem, Catarina F...... 332 He, Qun ...... 1596 Hewitt, Charles W...... 2203 Honda, Akira ...... 2090, 2134 He, Weiya ...... 1372 Heyer, Erin ...... 490 Honda, Kazuhisa ...... 2172 He, Xiangwei ...... 2227 Heyer, Laurie J...... 1741 Hone, James C...... 813 He, Yingwei ...... 1370 Hickey, Dominic ...... 518, 520 Hong, Amy ...... 969 He, Zuping ...... 199, 211, 1556, 2202 Hierro, Aitor ...... 1108 Hong, Jang Hee ...... 1562, 1860, 1863, 1865 Head, David A...... 1636 Higginbotham, James N...... 1628, 2012 Hong, Ki Sung ...... 203 Heard, Edith ...... 2408 Higgs, Henry N...... 1028, 1031, 1034, 1037 Hong, Mansoo B...... 178 Heck, Susanne ...... 1701 Hildebrandt, Emily R...... 385 Hong, Sung Hee ...... 1872 Heda, Ghanshyam D...... 1977 Hilderbrand, Susana ...... 1773 Hong, Seung Hwan ...... 200 Heidtman, Matthew ...... 2108 Hilfi nger, Andreas ...... 471 Hong, Suk J...... 1933 Heikal, Ahmed A...... 1137, 1286, 1931, 2068 Hill, Caroline ...... 870 Hong, Wanjin ...... 1085 Hein, Jotun ...... 1212 Hill, Donna ...... 1268 Honglin, Li ...... 1451 Heinbockel, Thomas ...... 778 Hill, Dani ...... 1539 Hongo, Etsuko ...... 149 Heinz, William F...... 1788 Himes, B. T...... 2295 Honnorat, Jérome ...... 786 Held, Michael ...... 658 Hinchcliffe, Edward H...... 643, 1490, 2256 Honsho, Masanori ...... 1383 Helfman, David M...... 940, 1553, 2327 Hinshaw, Jenny E...... 837, 1093 Honts, Jerry E...... 948, 1745 Heliot, Laurent ...... 152 Hirai, Yuya ...... 1949 Hoogenraad, Casper C...... 20, 48, 708, 717 Heller, Evan R...... 813 Hirano, Yasuhiro ...... 1944, 1949 Hook, Jeff ...... 1676 Heller, Mary ...... 1559 Hiraoka, Yasushi ...... 1256, 1951 Hooker, Tanya ...... 1630 Helman, Daniel J...... 553 Hirashima, Naohide ...... 265, 270, 305 Hoopes, Laura L. M...... 1741 Helmke, Brian P...... 1901 Hirata, Dai ...... 665 Hoops, Harold ...... 758 Helmke, Kara ...... 845 Hirayama, Toshiya ...... 1324 Hoover, Holly ...... 1874 Helton, Thomas D...... 49 Hirokawa, Nobutaka ...... 392, 1726 Höpken, Uta E...... 557 Hemati, Nahid ...... 226 Hirsch, Rhoda E...... 450 Horie, Hidenori ...... 2015 Hemler, Martin ...... 882 Hirshberg, Koret ...... 1106 Horigome, Tsuneyoshi ...... 1944 Hemmings, Brian A...... 1562 Hisano, Setsuji ...... 2020 Horikoshi, Nobuo ...... 1837 Hendershot, Linda M...... 51 Hisatsune, Junzo ...... 1324 Horn, Troy A...... 1808 Henderson, E...... 1180 Hiser, Laree ...... 2335 Horne, Mary C...... 1359, 1546 Henderson, Gregory P...... 2421 Hitomi, Jiro ...... 69 Hornick, Emma E. L...... 1248, 2360 Henderson, Matthew P. A...... 1078 Ho, Jianghai ...... 1444 Hornick, Jessica ...... 643, 1490 Hendrick, Chris ...... 1603 Ho, Shiuh-rong ...... 858, 1404 Horowits, Robert ...... 732, 733 Hendrickson, Carolyn ...... 374 Hobbs, Kimberly A...... 1176 Horowitz, Arie ...... 902, 1307, 2269 233 AUTHOR INDEX The American Society for Cell Biology 47th Annual Meeting December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

Horowitz, Mia ...... 1106, 86 Huang, Yuan-Ping ...... 1529 Horvath, Samantha ...... 202 Huang, Ying-Ming ...... 944 I Horwitz, Alan F...... 407, 475, 1269, 2266, 2317 Huard, Johnny ...... 208 Iannaccone, Philip ...... 212 Hoshino, Sachiko ...... 2011 Huarte, Maite ...... 2438 Ibrahim, Khalil ...... 2186 Hoshino, Tatsuya ...... 1883 Hubbert, Charlotte ...... 1825 Ichikawa, Hitoshi ...... 900 Hoskins, Sally G...... 1750 Hubenschmidt, Mark ...... 490 Ideker, Trey ...... 575, 1629 Hosoya, Yumiko ...... 509 Huber, Michael ...... 1957 Idone, Vincent ...... 273 Hossain, Sajjad ...... 1701 Huberman, Andrew D...... 2399 Iemura, Shun-ichiro ...... 253 Hou, Tieying ...... 148 Huckle, William R...... 136 Igarashi, Osamu ...... 1341 Houalla, Tarek ...... 1986 Hudson, Lynn D...... 789 Igdoura, Suleiman ...... 1382 Houdusse, Anne M...... 1696 Huebner, Stefan ...... 1915, 2359 Iglesias, Pablo A...... 1635, 2255 House, Reniqua P...... 1484 Hueston, Jennifer ...... 765 Iguchi, Tokuichi ...... 397 Houston, Clifford W...... 1739 Huff, Joseph ...... 1939 Ihrke, Gudrun ...... 1374 Hovhannisyan, Ruben ...... 585 Huggins, Iain ...... 92 Iida, Akira ...... 2175 How, Poh Choo ...... 2006 Hughes, Julian R...... 748 Ikebe, Mitsuo ...... 954, 994 Howard, Jonathon ...... 751 Hughes, Richard A...... 1787 Ikebe, Reiko ...... 994 Howard, Pamela S...... 690 Hughson, Frederick M...... 2001 Ikeda, Kazuo ...... 2019 Howe, Margaret C...... 242 Huh, Nam-ho ...... 1366, 2197 Ikeda, Shigaku ...... 89 Howe, Rachael ...... 218 Huh, Sung Hoon ...... 1167 Ikeda, Yasuhiro ...... 514 Howell, Audrey S...... 1039 Huh, Yang H...... 1948 Ikegami, Koji ...... 860 Howell, Bonnie J...... 1190 Huisinga, Kathryn L...... 113 Ikegami, Takahisa ...... 764 Howell, Justin ...... 386 Huizing, Marjan ...... 518, 520 Ikekawa, Nobuo ...... 1527 Howlin, Jill ...... 2013 Hulkova, Helena ...... 517 Ikemizu, Shinji ...... 1379 Hoyt, Myles A...... 385 Hull, Michael ...... 2076 Ikeo, Takashi ...... 690 Hozumi, Kentaro ...... 874, 875 Hulsmeier, Andreas J...... 1086 Im, Yang Ju ...... 1563 Hristovski, Kiril ...... 85 Hultqvist, Greta ...... 1270 Imai, Hiroshi ...... 1477 Hrizo, Stacy L...... 1158 Hum, Wah-Tung ...... 1926 Imai, Katsuyuki ...... 1218 Hsiao, Joshua P...... 1258 Humbel, Bruno M...... 1935 Imai, Misa ...... 579 Hsieh, Chia-Jung ...... 692 Humbert, Sandrine ...... 1509, 1607 Imajo, Masamichi ...... 604 Hsieh, Mei-Yi ...... 1537 Hummell, Erica V...... 1911 Imaki, Junko ...... 2027 Hsieh, Sherry ...... 2356 Humphrey, Rachel ...... 1799 Imamula, Kenji ...... 491 Hsin, Ling-Wei ...... 1351 Humphries, Martin J...... 1727 Imanaka-Yoshida, Kyoko ...... 328, 375 Hsu, Nai-Yun ...... 540 Humsi, Michael K...... 1658 Imanishi, Ken’ichi ...... 1341 Hsu, Su-Ming ...... 1398 Hung, Liang-Yi ...... 2180 Imbert, Isabelle ...... 1066, 2167 Hsu, Shu-Chan ...... 2125 Hung, Nai-Jung ...... 845 Imperiali, Barbara ...... 407 Hsu, Yueh-mei ...... 592 Hunt, Alan J...... 1500 In, Julie G...... 2122, 2135 Htun, Han ...... 162 Hunt, Donald F...... 1236 Inagaki, Naoyuki ...... 2286 Hu, Dong-Liang ...... 1341 Hunt, Lauren ...... 1998 Incao, Arturo ...... 2031 Hu, Jianli ...... 2287 Hunt, Margaret ...... 74 Indrei, Anca ...... 689 Hu, Ke ...... 946 Hunt, Richard C...... 74 Indrei, Lucian Laurentiu ...... 689 Hu, Lulin ...... 583 Hunter, Jessica ...... 1372 Ingber, Donald ...... 1776 Hu, Peng ...... 1239 Huo, Liang ...... 1670 Inglese, James ...... 103 Hu, Qicong ...... 947 Huppi, Konrad ...... 2441 Inglis, Peter N...... 465 Hu, Tianhui ...... 2142 Huq, Jameela ...... 1871 Ingraham, Holly A...... 856 Hu, Yan ...... 110 Hur, Gang Min ...... 1562, 1860, 1863, 1865 Ingraham, Jared G...... 856 Hu, Ya-Fang ...... 600 Hur, Kyu Chung ...... 682 Inman, Jamie L...... 1071 Hua, Lu ...... 140 Hurley, James H...... 1091, 1108 Inoh, Yoshikazu ...... 305 Hua, Shasha ...... 2233 Hüsken, Katrin ...... 2362 Inomoto, Takahiro ...... 1782 Hua, Xianxin ...... 585 Hussain, Naveen ...... 629 Inoue, Sadayuki ...... 1789 Huang, Bing Q...... 455, 456, 457, 1393 Husson, J...... 747 Inoue, Takanari ...... 1413 Huang, Chi-Chen ...... 1868 Hutchinson, Anthony J...... 1384 Into, Takeshi ...... 1838 Huang, Cheng-Han ...... 1956 Huttenlocher, Anna ...... 811 Invernizzi, Pietro ...... 2353 Huang, Caoxin ...... 1958 Hutter, Dorothy ...... 606 Iohara, Koichiro ...... 1838 Huang, D...... 2295 Hutter, Heinz ...... 1219 Iomini, Carlo ...... 1830 Huang, Guocun ...... 1596 Hutton, John C...... 1151 Iosef, Cristiana ...... 679 Huang, Hsin-Yi ...... 1398 Huzil, Torin ...... 1457 Ip, Wallace ...... 2067 Huang, Hung-Chung ...... 1402 Hwang, Byung-Doo ...... 1560, 2155, 2290, 673, 674 Irani, Kaikobad ...... 151 Huang, Hayden ...... 907 Hwang, Il Y...... 2305 Iribarne, María ...... 287 Huang, James N...... 1363 Hwang, Nathaniel S...... 377 Irie, Shinkichi ...... 166 Huang, Kuo-Cheng ...... 1938 Hwang, You-Jin ...... 537, 591, 614, 686, 1229, 1399, Irving, Thomas C...... 486 Huang, Kaiyao ...... 990 1400, 2041, 2042, 2043, 2044, 2047, 2176 Irwin, Leslie E...... 225 Huang, Li ...... 196 Hwee, Foo Yong ...... 1707 Isaac, Berith ...... 1641 Huang, Pei-Hsin ...... 1398 Hyams, Jeremy S...... 1282, 1297 Isaac, Beth ...... 434 Huang, Pengyu ...... 642 Hyatt, Linzi ...... 2321 Isaji, Mamiko ...... 1695 Huang, Ping ...... 858, 1404 Hyeon, Changbong ...... 388 Isakowitz, Matthew E...... 556 Huang, Renjian ...... 1029 Hyereen, Kang ...... 139 Ishihara, Yoshie ...... 149 Huang, Sui ...... 1649 Hyman, Anthony ...... 631, 751, 1516 Ishii, Kohei ...... 1944 Huang, Sujuang ...... 386 Hyman, Bradley T...... 1095 Ishii, Kenichiro ...... 375 Huang, Wenwei ...... 103 Hynes, Richard O...... 67 Ishikura, Shuhei ...... 274, 2137 Huang, Wei ...... 217 Hyun, Sang W...... 2273 Ishitsuka, Reiko ...... 2070 Huang, Yanping ...... 1008 Ishiuchi, Takashi ...... 66 234 The American Society for Cell Biology 47th Annual Meeting AUTHOR INDEX December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

Isoda, MIho ...... 1299 Jang, An-Soo ...... 1406 Jin, Yijun ...... 2193 Isomoto, Hajime ...... 1324 Jang, Seung-Hoon ...... 247, 1522 Jin, Yui ...... 695 Israel, Mark A...... 588 Jang, Sang-Min ...... 156 Jing, Jian ...... 1109, 271 Israeli, Sharon ...... 1786 Jang, Sung-Wuk ...... 139, 1846 Jing, Kaipeng ...... 1560, 2155, 673, 674 Issever, Halim ...... 1068 Jani, Klodiana ...... 60 Jo, Tae-kyoung ...... 1399, 2041, 2042, Itabe, Hiroyuki ...... 508 Janicke, Marie A...... 633 2043, 2044, 2047, 2176 Itani, Wataru ...... 73 Janicki, Susan ...... 1234 Job, Didier ...... 2301, 2330 Ito, Eiko ...... 280 Janmey, P. A...... 1850 Jodoin, Julie ...... 1369 Ito, Hidenori ...... 1476 Jans, David A...... 846 Joensuu, Tarja ...... 1877, 1879 Ito, Megumu ...... 1826 Jansen, Gert ...... 454 Joglekar, Ajit P...... 1498, 1508, 2227 Ito, Masataka ...... 1838, 2027 Jansen, Karen A...... 1117, 1121 Johal, Malkiat ...... 2121 Ito, Masato ...... 94, 381 Janson, Marcel E...... 756 Johannes, Ludger ...... 831 Itoh, Hiroshi ...... 397 Janzen, Deanna ...... 1417 Johansen, Jorgen ...... 109, 2407, 651 Itoh, Kazuyuki ...... 1469 Jaqaman, Khuloud ...... 1096, 1496, 1501, 2235 Johansen, Kristen M...... 109, 2407, 651 Itoh, Motoyuki ...... 1299 Jarnik, Michal ...... 1235 John, Sam ...... 2410 Itoh, Sohei ...... 514 Jarvik, Jonathan ...... 900 Johne, Cindy ...... 1454 Itoh, Takuya ...... 1477 Jaspersen, Sue L...... 13, 1245 Johnson, Adriel D...... 1176 Ivanov, Ivaylo V...... 2143, 2144, 2145 Jaworski, Jacek ...... 48 Johnson, Arthur E...... 1156, 52 Ivanov, Pavel A...... 715 Jayapal, Senthil Raja ...... 927 Johnson, Arlen W...... 845 Ivanova, Natalia B...... 2447 Jayaraman, Muralidharan ...... 1565 Johnson, Briana L...... 2026 Iwai, Yasutomo ...... 1166, 1225, 1580 Jean, Steve ...... 2018 Johnson, Chad ...... 1282, 1297 Iwamoto, Hiroyuki ...... 978 Jeansonne, Beverly G...... 867 Johnson, Colin A...... 316, 460, 1000 Iwamoto, Ikuko ...... 1476 Jeffrey, Peter L...... 936 Johnson, Corey M...... 2062 Iwamoto, Masaaki ...... 1256 Jeffreys, Chris ...... 202 Johnson, Gary L...... 402 Iwamoto, Masahiro ...... 1310 Jékely, Gáspár ...... 1968 Johnson, Inneke ...... 1773 Iwasa, Janet H...... 1026 Jena, Bhanu P...... 255, 256 Johnson, I...... 1842 Iwasaki, Hideo ...... 1597 Jendrysik, Meghan A...... 1839 Johnson, J...... 1180 Iwase, Masayuki ...... 668 Jeng, Robert L...... 31 Johnson, Jacqui ...... 1189 Iwashita, Masaya ...... 283 Jenkins, Susan ...... 1565 Johnson, Jeff ...... 1392 Iyer, Aravind ...... 620 Jenne, Dieter ...... 96 Johnson, Jacque-Lynne F...... 1301 Izu, Yayoi ...... 1851 Jennifer, Oberg C...... 857 Johnson, Jeriel L...... 1176 Izumchenko, Eugene ...... 1471 Jennings, Jean M...... 2357 Johnson, Jennifer L...... 1340 Jensen, Grant J...... 2421 Johnson, Jill L...... 54 J Jenssen, Håvard ...... 1403 Johnson, Jon P...... 889 Jaafar, Leila ...... 432 Jeon, Noo Li ...... 1880 Johnson, Jacqueline U...... 1176 Jabeen, Effat ...... 193 Jeon, Su Yeon ...... 1067 Johnson, Kandice R...... 341 Jacinto, Antonio ...... 87 Jeong, Goo-Bo ...... 1659 Johnson, Keith R...... 352, 887, 1584 Jackson, Bruce A...... 1285 Jeremic, Aleksandar ...... 256 Johnson, L. Jeffrey ...... 1394 Jackson, Kath ...... 1315 Jerka-Dziadosz, Maria ...... 2396 Johnson, Mark ...... 1926 Jackson, Kristopher ...... 606 Jeromin, Andreas ...... 612 Johnson, Reid ...... 1970 Jackson, RaElle ...... 1277 Jessen, Jason ...... 886 Johnson, Ross ...... 913 Jackson, Sharon ...... 555, 1839 Jha, Ramesh ...... 1408 Johnson, Ron L...... 103 Jackson, Shirley Ann ...... 2 Jha, Sudhakar ...... 1242 Johnson, Scott ...... 292 Jackson, Thomas N...... 944 Ji, Andrew ...... 873 Johnson, Sally E...... 2016, 2152 Jacob, Ralf ...... 2123 Ji, Julie Y...... 569 Johnson, Thomas A...... 2410 Jacobs, Cassandra ...... 289 Ji, Lin ...... 470, 1633, 2298 Jonassen, Julie ...... 453 Jacobs, Damon T...... 956, 963, 965 Ji, Peng ...... 927 Jones, Jonathan C...... 1482, 1764 Jacobs-Wagner, Christine ...... 855 Ji, Qiongmei ...... 1956 Jones, Leanne ...... 2445 Jacobson, Fredric ...... 1358 Ji, Zhiliang ...... 1958 Jones, Marcella ...... 1921 Jacobson, Ken ...... 279, 702, 1012, 2072 Ji Hshiung, Chen ...... 592 Jones, MaryPat ...... 2200 Jacobson, Matthew P...... 1779 Jia, Junyong ...... 1140 Jones, Rachel ...... 1212 Jacoby, Ethan ...... 1756 Jia, Zhiheng ...... 1025 Jones, Richard ...... 2057 Jacquemin, Emmanuel ...... 2119 Jia, Zongjian ...... 126 Jones, Steven L...... 1276 Jaeger, Ruy G...... 326, 327, 1357 Jia, ZongChao ...... 1481 Jones, Tamara L...... 2441 Jaffe, Laurinda A...... 918 Jia, Zhenyu ...... 900 Jonnasson, Erin ...... 1015 Jaiswal, Aruna S...... 1859 Jiang, Hai ...... 1451 Joo, Lucy ...... 1234 Jaiswal, Jyoti K...... 263 Jiang, Jiji ...... 199, 211, 1556, 2202 Jordan, Mary Ann ...... 1449, 1457 Jakub, Famulski ...... 1605 Jiang, Kai ...... 2237 Jose, Cynthia ...... 1770 Jameel, Shahid ...... 533 Jiang, Pengju ...... 59 Joseph, Jayabalan M...... 2377 James, Kristy M...... 2191 Jiang, Qiong ...... 104 Joshi, Bharat ...... 126, 1473 James, Umen ...... 14 Jiang, Qing ...... 1542 Joshi, Sagar D...... 2024 Jameson, Samantha A...... 1063 Jiang, Wen G...... 877 Jourdain, Isabelle ...... 1282, 1297 Jamora, Colin ...... 343 Jiang, Ziying ...... 1142 Jovic, Marko ...... 1107 Jamur, Maria Celia ...... 301, 2084 Jiménez, Nuria ...... 2104 Joyce, Michael ...... 823 Jan, Lily Y...... 46 Jimenez-Mateos, Eva Maria ...... 760 Jozwiak, Jolanta ...... 938 Jan, Yuh-Nung ...... 46 Jin, Changjiang ...... 2233 Ju, Seong-A ...... 551, 1360 Jana, Siddhartha S...... 2304 Jin, Chunyuan ...... 819 Juergens, Jeffery Taylor ...... 2053 Janáky, Tamás ...... 2073 Jin, Eun-Jung ...... 1304, 1312 Juliano, Celina E...... 2052 Jane, Esther P...... 202 Jin, Hee kyung ...... 1878 Juliano, Rudy ...... 403 Janes, Kevin A...... 2420 Jin, Huan ...... 256 Jülicher, Frank ...... 1516, 1612, 1638 Janetopoulos, Chris ...... 1672 Jin, Hye Jin ...... 572 Jun Young, Heo ...... 2290 235 AUTHOR INDEX The American Society for Cell Biology 47th Annual Meeting December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

Jun-Ichi, Hayashi ...... 1368 Kantola, Anna K...... 1792 Kedrin, Dmitriy ...... 1472 Jung, Goeh ...... 934 Kanungo, Jyotshna ...... 1057 Kee, Anthony J...... 1676 Jung, Ho Won ...... 30 Kao, Ling R...... 1439 Kee, Yee-Seir ...... 1635 Jung, H. S...... 720 Kao, Yulin ...... 616 Keegan, Kevin ...... 1594 Jung, Jae-Won ...... 1856 Kapinos, Larisa ...... 2358 Keely, Patricia J...... 1757, 1761, 2415 Jung, Sungyong ...... 101 Kapitein, Lukas C...... 384, 756, 834 Keembiyehetty, Chithra N...... 859 Jung, Soo Kyung ...... 1397 Kaplan, Daniel D...... 1428 Keen, James H...... 2096 Jung, Sung-hwan ...... 1399 Kaplan, Zachary B...... 2278 Keener, Mary Beth ...... 2322 Jung, Yeon-Joo ...... 673, 674, 1560, 2155, 2290 Kapoor, Mohit ...... 1820, 1824 Keeney, Paula M...... 178 Jung, Young-Hoon ...... 674 Kapoor, Tarun M...... 834, 1647 Keeven, James K...... 1832 Jupiter, Daniel C...... 1211, 1402 Kapoor, V. K...... 523 Kehoe, Sarah M...... 2040 Jurjus, Rosalyn A...... 872, 884, 2276 Kapus, Andras ...... 1082, 1284, 1758 Kehrl, John H...... 2305 Justman, Quincey A...... 1600 Kapustina, Maryna T...... 702, 1012 Keiichiro, Kyozuka ...... 2049 Juvekar, Ashish P...... 1862, 1867 Kar, Ashok ...... 2205 Keiko, Steve ...... 2237 Karabay, Arzu ...... 2294, 2299 Keim, Sarah A...... 887 K Karacsonyi, Claudia ...... 295 Kellard, Libby ...... 213, 214 Kabaritti, Rafi ...... 2329 Karamichos, Dimitrios ...... 309 Keller, Lani C...... 631, 1431 Kabashima, Narutoshi ...... 1811 Kardon, Julia R...... 1665 Keller, Thomas C...... 444 Kadomatsu, Kenji ...... 593 Karginov, Andrei V...... 1914 Kelley, Joshua B...... 1947 Kadoya, Toshihiko ...... 2015 Karhanek, Miloslav ...... 1207 Kelly, Alexander E...... 2223 Kadrmas, Julie L...... 222 Karjalainen, Mikko ...... 298 Kelly, Deirdre A...... 460 Kaech, Stefanie ...... 1725 Karnik, Parul ...... 1741 Kelly, Isabelle ...... 91 Kahsai, Alem W...... 2270 Karpova, Tatiana S...... 152 Kelly, Mark J. S...... 1779 Kai, Hirofumi ...... 158, 574, 1379, 1530 Karsenti, Eric ...... 743 Kelly, Sean ...... 176 Kaibuchi, Kozo ...... 1367, 775 Karuturi, Krishna ...... 2150 Kelly, Shannon D...... 145 Kaieda, Shuji ...... 764 Karwa, Amol ...... 99 Kelly, Terri-Ann N...... 1461 Kaipeng, Jing ...... 2290 Kasad, Roshni A...... 1641 Kelly, William G...... 818 Kaiser, Christina G...... 1803 Kasahara, Atsuko ...... 1890, 1898 Kelman, Zvi ...... 1540 Kajanne, Risto M. A...... 678 Kasahara, Hideko ...... 1837 Kelsey, Jessica S...... 186 Kajava, Andrey V...... 1108 Kashgarian, Michael ...... 1694 Kelso, Bret G...... 1574 Kakkonen, Elina ...... 298 Kashina, Anna ...... 469, 862, 1533, 2378 Kemper, Sherri ...... 2194 Kalaidzidis, Yannis ...... 1984 Kasili, Paul M...... 1206 Kendall, Stephen E...... 1188 Kalamegham, Rasika ...... 1076 Kasprzak, Andrzej ...... 1718 Kennedy, Brian K...... 1063 Kalb, Robert ...... 1659 Kastner, Peter M...... 2245 Kennedy, Laura ...... 1820 Kalman, Roni ...... 501 Kasza, Karen E...... 471, 747, 935 Kennedy, Mary B...... 1267 Kaltenbronn, Kevin ...... 1565 Katagiri, Yasuhiro ...... 1461 Kenneth, Wong ...... 281 Kamasawa, Naomi ...... 910 Katanosaka, Yuki ...... 1126 Kenney, Nicholas ...... 1770 Kameda, Yoko ...... 2027 Kataoka, Ken ...... 2197 Kenski, Denise ...... 1984 Kamel, George ...... 1783 Kathir, Karuppanan M...... 2186 Kenth, Sukhdeep ...... 1065 Kametani, Fuyuki ...... 2015 Kato, Fuminori ...... 1197 Kenworthy, Anne K...... 2100, 2434 Kamiguchi, Hiroyuki ...... 1711, 2286 Kato, Hidehito ...... 1341 Kenzelmann, Daniela ...... 903 Kamijo, Keiju ...... 653 Kato, Mihoko ...... 1077 Keough, Edward ...... 1190 Kamimura, Yoichiro ...... 414 Kato, Masanari ...... 1197 Kerber, Michael L...... 956 Kamiyama, Daichi ...... 1308 Kato, Masaki ...... 1813 Kerkhoff, Eugen ...... 25 Kamp, Anna ...... 1603 Kato, Shigeaki ...... 1218 Kerman, Bilal E...... 1010 Kamura, Eri ...... 1292 Kato, Yukio ...... 2124 Kerns, Michelle L...... 42 Kan, Ho-Man ...... 1024 Katsanis, Nicholas ...... 465, 1813 Kerr, Bethany ...... 1310 Kanai, Masahiro ...... 375 Katsuno, Tatsuya ...... 1997 Kerscher, Oliver ...... 1502 Kanaya, Takashi ...... 73 Katti, Christiana ...... 1692 Kesari, Akanchha ...... 560 Kanda, Hideki ...... 375 Katz, David J...... 818 Kesavapany, Sashi ...... 2350 Kandachar, Vasundhara ...... 192 Katz, Jonathan P...... 72 Keski-Oja, Jorma ...... 1792 Kaneda, Yasufumi ...... 1197 Katzav, Shulamit ...... 1106 Kessenbrock, Kai ...... 96 Kaneko, Tatsuro ...... 1711 Kaushik, Gaurav ...... 84 Ketschek, Andrea R...... 1276, 2292, 2296 Kaneko, Tomoyuki ...... 899 Kaushik, Toshi ...... 84 Kettle, Emma ...... 1676 Kaneski, Christine R...... 519 Kaverina, Irina ...... 709, 809 Keum, Ji Hyun ...... 537, 614, 686 Kang, Chang-Mo ...... 1605 Kawaguchi, Shin-ichi ...... 1436 Keyes, Brice E...... 1504 Kang, Eun-Sil ...... 601 Kawamoto, Sachiyo ...... 2304 Keyes, Lance ...... 337 Kang, Heegoo ...... 1304 Kawamura, Ryo ...... 118 Khaidakova, Galimat ...... 2000 Kang, Inkyung ...... 323 Kawate, Toyoko ...... 466 Khalil, Sheede ...... 366 Kang, Linda ...... 2082 Kawedia, Jitesh ...... 345 Khan, Protiti ...... 940 Kang, Man J...... 240, 1760 Kay, Brian K...... 1411, 1937 Khandelwal, Puneet ...... 1113 Kang, Pil Jung ...... 677 Kay, EunDuck P...... 2164 Khanna, Mansi R...... 1001 Kang, Qiaozhen ...... 594 Kay, Rob R...... 415 Kherrouche, Zulika ...... 152 Kang, Shin-Sung ...... 1304, 1312 Kazunori, Kondo ...... 394, 396 Khodjakov, Alexey ...... 645 Kang, Seongman ...... 2154 Kazuto, Nakada ...... 1368 Khorasanizadeh, Sepideh ...... 2219 Kang, Shin-Ae ...... 2279 Ke, Guifen ...... 1958 Khotin, Mikhail ...... 1577 Kang, Sung Wook ...... 681 Keady, Brian T...... 451 Khounlotham, Manirath ...... 1332 Kang, Young H...... 649 Kean, Michelle J...... 1775 Khurana, Bharat ...... 1770 Kannegaard, Elisa S...... 984 Kearney, Robert E...... 1627 Khurana, Seema ...... 949 Kano, Fumi ...... 132 Keaton, Jason M...... 2204 Khusial, Permanan R...... 995 Kano, Masayuki ...... 1362 Keck, Kristin M...... 1236 Kiel, David H...... 6 236 The American Society for Cell Biology 47th Annual Meeting AUTHOR INDEX December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

Kiel, Tilman ...... 1915, 2359 Kim, Moon G...... 1060, 1762, 2302 Klemm, Anna H...... 876 Kiema, Tiila ...... 59 Kim, Mee J...... 519 Klessner, Jodi L...... 369 Kienle, Nickias ...... 1620 Kim, Nam Youl ...... 101 Kleve, Maurice ...... 1153 Kieselbach, Thomas ...... 840 Kim, Nam-Hoon ...... 1900 Kline, Joel N...... 463 Kieserman, Esther K...... 691 Kim, Sung Min ...... 1167 Klingberg, Henrik ...... 1150 Kikkawa, Namiko ...... 1401 Kim, Seongjae ...... 1442 Klip, Amira ...... 274 Kikkawa, Yamato ...... 874, 875 Kim, Sunghwan ...... 1443 Klonis, Nick ...... 1315 Kikuchi, Ken-Ichiro ...... 345 Kim, Sun-Uk ...... 147 Kloog, Yoel ...... 304 Kilbourne, Ed ...... 1926 Kim, Sujeong ...... 1605 Klootwijk, Riko ...... 518, 520 Kilburn, Chandra L...... 970 Kim, Sol ...... 1866 Klopocka, Wanda ...... 1697 Kilimann, Manfred W...... 1270 Kim, Sung-Soo ...... 247 Klos, Deborah A...... 1008 Killilea, Alison ...... 1511 Kim, Sunyoung ...... 382 Kmoch, Stanislav ...... 517 Kilman, Valerie ...... 1594 Kim, Sung Jun ...... 614, 1229, 1400 Knafelc, Stacey M...... 2191, 2192 Kim, Byung-Ju ...... 1988 Kim, Soowhan ...... 683 Knapik, Ela W...... 2111, 2113 Kim, Beom Su ...... 2051 Kim, Sangwon V...... 1608 Knecht, David A...... 417, 1417, 1848, 2324 Kim, Byung-Sam ...... 551, 1334, 1360 Kim, Tae Young ...... 1167 Knezevic, Ivana ...... 1908 Kim, Chong Jai ...... 2198 Kim, Tae Hee ...... 1762 Knight, Clayton ...... 1363 Kim, Chi Dae ...... 421, 603 Kim, Taeyoon ...... 768 Knight, Kendall L...... 2425 Kim, Dae Kwan ...... 200 Kim, Thomas D...... 1396 Knight, Peter J...... 960, 961 Kim, Dae Young ...... 537, 591, 614, 686, 1229, 1399, Kim, Uh-Hyun ...... 1988 Knoblach, B...... 1625 1400, 2041, 2042, 2043, 2044, 2047, 2176 Kim, Woe-Yeon ...... 1595 Knorr, Ruth ...... 295 Kim, Dongkyun ...... 1304 Kim, Wook-Hwan ...... 247 Knorre, Dmitry ...... 1289 Kim, D. U...... 2064 Kim, Yeon Ju ...... 1167 Knowlton, Anne L...... 1448, 1643 Kim, Eun Kyoung ...... 421, 603 Kim, Yeon-Jin ...... 1298 Knudson, Cheryl B...... 1579 Kim, Eun Mi ...... 681 Kim, Yoon Suk ...... 139, 1846 Knudson, Warren ...... 1578, 1579 Kim, Eun J...... 859 Kim, Yoon-seob ...... 1399, 2041, 2042, Ko, Chiung-Yuan ...... 1353 Kim, Gun-Hwa ...... 1043 2043, 2044, 2047, 2176 Ko, David ...... 1095 Kim, Gi Jin ...... 1067, 2198 Kim, Young-Eun ...... 1406 Ko, Jesang ...... 139, 1846 Kim, Hi Chol ...... 101 Kim, Yumi ...... 1595 Ko, Ji-Ae ...... 864, 896 Kim, HakRim ...... 1021 Kim, Young Rae ...... 1562, 1860, 1863, 1865, 2290 Ko, Kyoung-Won ...... 680, 688 Kim, Ha Won ...... 1397 Kim, Yumi ...... 2240 Koach, Margaret A...... 2317 Kim, Ha-Neui ...... 1566 Kim, Youngsoo ...... 601 Kobayashi, Kazuhiro ...... 1380 Kim, Hwajin ...... 1735 Kimura, Ikuo ...... 508 Kobayashi, Toshihide ...... 653, 2070 Kim, Hye Min ...... 171, 179 Kincaid, Margaret M...... 1666 Koch, Annett ...... 2123 Kim, Hyun Hee ...... 1853 Kindler, Stefan ...... 773 Koch, Thorsten ...... 1802 Kim, Hye Kyoung ...... 201 Kinet, Jean-Pierre P...... 552 Kocik, Elzbieta ...... 938, 1718 Kim, HyeYoung ...... 2033 King, Catrina ...... 585 Kodali, Vamsi ...... 1801 Kim, Hyo-hyun ...... 1399, 2041, 2042, King, Emma M...... 1496 Kodiha, Mohamed ...... 502 2043, 2044, 2047, 2176 King, Megan C...... 1655 Koeckert, Michael S...... 813 Kim, Hangun ...... 376 King, Stephen J...... 493, 1666, 1667 Koegler, Eva ...... 2105 Kim, Ho-Shik ...... 680, 688 King, Stephen M...... 489, 991 Koenderink, Gijsje H...... 836, 935 Kim, Hey M...... 1760, 240 King-Smith, Christina ...... 697, 698 Koeneman, Brian A...... 85 Kim, Ick Young ...... 1847, 2028, 2029 Kingsbury, Tami ...... 385 Koepp, Deanna M...... 2162 Kim, In-Sook ...... 1569, 1900 Kinjo, Masataka ...... 1946 Koeser, Joachim ...... 842 Kim, Jin Kyeoung ...... 1067 Kinoshita, Kazuhisa ...... 751 Koga, Tomoaki ...... 158 Kim, Jae Young ...... 1167 Kioka, Noriyuki ...... 1477, 1782 Koh, Ara ...... 1549 Kim, Jae Yoon ...... 1549 Kiprilov, Enko N...... 450 Kohara, Arihiro ...... 102 Kim, Jung Hwan ...... 1549 Kirchberg, Marci ...... 1994 Kohara, Yuji ...... 416 Kim, Jung-Woong ...... 156 Kireev, Igor ...... 110 Kohler, Jeffrey ...... 90 Kim, Jeongsik ...... 1595 Kiris, Erkan ...... 1449, 1463 Kohlmaier, Gregor ...... 1441 Kim, Jisoo ...... 1762 Kirk, Karen E...... 117 Kohno, Shigeru ...... 1324 Kim, Jae-Hong ...... 1847 Kirschner, Marc W...... 1041 Koivusalo, Mirkka A...... 302 Kim, Jungho ...... 1866, 201 Kiselyov, Kirill ...... 675, 1975 Kojidani, Tomoko ...... 1256, 1951 Kim, Jong Soo ...... 203, 228 Kiser, Timothy D...... 2273 Kojima, Hiroaki ...... 979 Kim, Jong-Seok ...... 673, 674, 1560, 2155, 2290 Kishida, Koichi ...... 181 Kojima, Shin-ichiro ...... 1946, 2361 Kim, Jung-Gun ...... 28 Kishimoto, Takuma ...... 2130 Kokanovich, Kate ...... 629 Kim, Jae Woo ...... 510 Kiss, Alexi ...... 351 Kokkinaki, Maria ...... 199, 211, 1556 Kim, Jun Hwan ...... 544 Kita, Katsuhiro ...... 438 Kokoski, Candis L...... 806 Kim, Jin-Man ...... 683 Kitagawa, Katsumi ...... 2212 Kolb, Juergen F...... 684 Kim, Jin Yong ...... 680, 688 Kitami, Yoshikazu ...... 466 Koleske, Anthoney J...... 1873 Kim, Kye-Seong ...... 203, 228 Kitamura, Tetsuo ...... 899 Koli, Katri ...... 1792 Kim, Kye-Young ...... 2304 Kitazoe, Midori ...... 1366, 2197 Kollins, Katherine M...... 2287 Kim, Ki D...... 1948 Kitlinska, Joanna ...... 617 Kollmannsberger, Philip ...... 432, 876, 1713, 1802 Kim, Kye Y...... 2305 Kittinger, Ben ...... 1741 Kollu, Swapna ...... 1500 Kim, Mee Kum ...... 1829 Kiyomitsu, Tomomi ...... 1493 Kolobova, Elena ...... 709 Kim, Minsoo ...... 1840 Kiyono, Hiroshi ...... 1341 Kölsch, Anne ...... 2346 Kim, Mi-Yeon ...... 1568, 1569, 1570, 1889 Kizhatil, Krishnakumar ...... 2075 Komatsu, Kensei ...... 158 Kim, Myung-Deok ...... 247 Kizilay, Ozge ...... 1991 Kominami, Eiki ...... 89 Kim, Min Ji ...... 152, 591, 1229, 1400 Klebig, Christiane ...... 1492 Komiyama, Noboru H...... 1311 Kim, Min Sung ...... 421, 603 Klein, Irene K...... 261 Kon, Takahide ...... 491 Kim, Min C...... 1060 Klein, Thomas J...... 191 Kondo, Kazunori ...... 390 237 AUTHOR INDEX The American Society for Cell Biology 47th Annual Meeting December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

Kondo, Yoshitaka ...... 1197 Kronja, Iva ...... 743 Kvansakul, Marc ...... 1795 Kondoh, Kunio ...... 604 Krotzer, Steven ...... 1190 Kwak, Han Bok ...... 1566 Kondratov, Roman ...... 1599 Kroy, Klaus ...... 2376 Kwan, Raymond N...... 1390, 2347, 2348 Kong, Chen ...... 2093 Krueger, Susan ...... 1089 Kweon, Gi-Ryang ...... 673, 674, 1560, 2155, 2290 Kong, Wuyi ...... 251 Krufka, Alison ...... 913 Kwok, Benjamin H...... 834 Konishi, Tetsuya ...... 1527 Kruhlak, Michael ...... 116 Kwon, Joon Hyun ...... 1847 Kono, Keiko ...... 926 Kruljac-Letunic, Anamarija ...... 743 Kwon, Mijung ...... 640 Kono, Tomohiro ...... 568 Krum, Janette ...... 2014 Kwon, Yong Jun ...... 101 Konstantopoulos, Konstantinos ...... 1808 Krutchinsky, Andrew N...... 115 Kwon, Young-Guen ...... 1856 Kontrogianni-Konstantopoulos, Aikaterini ...... 1004 Ku, Nam O...... 41, 2348 Kwonseop, Kim ...... 376 Konzack, Sven ...... 752 Ku, Wei ...... 1529 Kynaston, Howard ...... 877 Koonce, Michael ...... 1729, 2215 Kublova, Martina ...... 517 Kyoung, Minjoung ...... 1137 Kopesky, Paul W...... 2413 Kubo, Akiharu ...... 1997 Kyrtsos, Christina R...... 1938 Kopp, Petra ...... 483 Kubo, Yoshiyuki ...... 2124 Kyryakov, Pavlo ...... 1065 Kopp, Sandra A...... 2203 Kudlow, Brian A...... 1063 Kyung Han, Song ...... 543 Kopra, Outi ...... 1877, 1879 Kudlow, Jeffrey E...... 858, 1404 Korchynskyi, Olexandr ...... 1814 Kudryashov, Dmitri S...... 2375 L Kordowska, Jolanta ...... 1029 Kueh, Hao Yuan ...... 2390 Laakso, Joseph M...... 1688 Korn, Edward D...... 1690 Kuehn, Michael ...... 1055 Laan, Liedewij ...... 19, 1452, 1453 Korneev, Mikahil ...... 384 Kuervers, Lynnette ...... 2056 Labay, Valentina ...... 1134 Korobova, Farida ...... 469 Kuhajda, Frank ...... 1864 Labeit, Siegfried ...... 721 Korrapati, Soumya ...... 1391 Kuhlman, Brian ...... 1408 Lachiewicz, Anne ...... 596 Kortan, Melisa B...... 957 Kuhn, Hallie ...... 490 Lad, Yatish ...... 59, 1761, 2415 Korulu, Sirin ...... 2294 Kuhn, Thomas B...... 2369 Lader, Eric ...... 2441 Kosaka, H...... 1642 Kühne, Fabiana ...... 319 Ladher, Raj K...... 2134 Koshimizu, Hisatsugu ...... 768 Kukreja, Lokesh ...... 1894 Lafer, Eileen M...... 1089 Kosinetz, Claudia ...... 1363 Kukuruzinska, Maria A...... 366, 370 LaFountain, James R...... 633, 637 Koster, Abraham J...... 1117, 1121, 1935 Kulakowska, A...... 1850 Lagos, Luisa ...... 527 Kostyukova, Alla S...... 1699 Kuliawat, Regina ...... 1120 Lagziel, Ayala ...... 1224 Kotani, Norito ...... 979 Kulic, Igor M...... 1735 Lai, Chun-Wei W...... 180 Kotenko, Iulia ...... 2447 Kuligovski, Crisciele ...... 1182 Lai, Yumei ...... 2083 Kothary, Rashmi ...... 945, 993 Kulkarni, Madhura ...... 2045 Lainé, Jeanne ...... 777 Kotova, Elena ...... 1235 Kulkarni, Rishikesh M...... 1906 Lainhart, William ...... 1326 Kottke, Margaret D...... 2357 Kulkarni, Sayali D...... 2369 Lajoie, Patrick ...... 262 Kotula, Leszek ...... 1701 Kulukian, Anita ...... 2231 Lakämper, Stefan ...... 384, 385 Kotwaliwale, Chitra ...... 2220 Kumabe, Shunji ...... 1166, 1580 Lakin, Christina N...... 1419 Koudelka, Gerald ...... 1326 Kumar, Nidhi ...... 879 Lakins, Johnathon ...... 314, 317, 323, 341, 2417 Koulakov, Alex ...... 239 Kumar, Praveen ...... 753 Lakshman, Neema ...... 309 Koulov, Atanas ...... 1621 Kumar, Ravindra ...... 1630, 1831 Lakshmanaswamy, Rajkumar ...... 1539 Koura, Minako ...... 2048 Kumar, Sanjeev ...... 1772 Lal Khanduja, Krishan ...... 84 Kovács, Mihály ...... 965 Kumar, Suresh ...... 2186 Lalani, El-Nasir ...... 218 Koval, Michael ...... 916 Kumar, Thallapuranam Krishnasuramy S...... 2183 Lalazarzedeh, Monika ...... 1155 Koval, Thomas ...... 1755 Kumar, Vineet ...... 154 Lam, Bernard ...... 142, 1922, 1923, 1924, 1925 Kovar, David R...... 929, 2389 Kumar, Yadunanda ...... 32 Lam, Hubert ...... 854, 855 Kovelman, Robert ...... 878, 1188, 1189 Kumaratilake, Jaliya S...... 230 Lamaze, Christophe ...... 831 Kowalczyk, Andrew P...... 353, 2357 Kume, Kazunori ...... 665 Lamb, Mary Rose ...... 1280 Kowalczykowski, Stephen C...... 2384 Kumeta, Masahiro ...... 1949 Lamers, Marcelo L...... 513, 2266 Kozminski, Keith G...... 429 Kumfer, Kraig T...... 1045 Lammerding, Jan ...... 569, 1254 Krag, David ...... 576 Kummer, J. Alain ...... 550 Lämmermann, Tim ...... 1467 Krahe, Ralf ...... 566, 567 Kundu, Chanakya N...... 1859 Lammers, Reiner ...... 483 Kraikivski, Pavel ...... 422, 701 Kung, Leslie ...... 2107 Lampson, Michael A...... 1647 Krapp, Andrea ...... 2246 Kunkel, Joseph G...... 1342 Lan, Rongfeng ...... 1542 Krasnec, Katina ...... 1277 Kunken, Joshua ...... 1496 Lan, Weijie ...... 1448, 2219, 2230 Krasnewich, Donna ...... 520 Kunz, Jeannette ...... 406, 408, 1005 Lanaspa, Miguel A...... 1128, 1966 Kraus, Michaela ...... 761 Kuo, Jean-Cheng ...... 1529 Landeryou, Mark ...... 484 Krauss, Michael ...... 1140 Kuo, Scot C...... 2255, 478 Landgraf, Dirk ...... 8 Krausz, Eberhard ...... 1984 Kuramasu, Atsuo ...... 776 Lane, William S...... 736, 2270 Kreher, Jeremy ...... 1514 Kurfürst, Robin ...... 1222 Lane-Guermonprez, Lydie ...... 1673 Kremer, Brandon E...... 937 Kurian, Mani V...... 1832 Langenbach, Kurt J...... 1797 Kremmer, Elisabeth ...... 1104 Kuriyama, Ryoko ...... 2211 Langford, George M...... 468 Krendel, Mira ...... 1608 Kurley, Sarah J...... 356 Langford, Kelly J...... 744 Kreplak, Laurent ...... 2339 Kuroda, Keisuke ...... 1367 Langley, Katherine J...... 879 Krezel, Andrzej M...... 2113 Kuronen, Mervi ...... 1877 Langlois, Frederic ...... 816 Kriebel, Paul W...... 411, 810 Kurrasch, Deborah M...... 856 Langshaw, Amber H...... 2066 Krise, Keith M...... 2068 Kushkuley, Jacob ...... 2349 Lansky, Zdenek ...... 389 Krishnaswamy, Guha ...... 692 Kushnir, Natasha ...... 398 Lanzavecchia, Salvatore ...... 987 Kristy, James M...... 2190 Kusiak, John W...... 1885 Lanzetti, Letizia ...... 1262 Kroeger, Cornelia ...... 40 Kusina, Jestina F...... 2369 Lapetina, Stefanie ...... 1705 Kroetz, Mary ...... 1502 Kutateladze, Tatiana ...... 2253 Lapierre, Lynne A...... 2012, 2099, 2100, 2434 Krogan, Nevan J...... 1632 Kuwabara, Kosuke ...... 1181 LaPointe, Paul ...... 1621 Kroll, Daniel M...... 1639 Kuznetsov, Igor R...... 1020 Lappalainen, Pekka ...... 921, 1015, 1681 238 The American Society for Cell Biology 47th Annual Meeting AUTHOR INDEX December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

Larimore, Jennifer L...... 45, 1268 Lee, Hye-Jung ...... 1186, 1187 Lee, Yu-Ru ...... 1529 Larkin, Josh ...... 636 Lee, Hayyoung ...... 1561 Lee, Yeon Kyung ...... 537, 614, 686 Larkin, Shannon M...... 321 Lee, Hyun Ju ...... 1829 Lee, Youn Sook ...... 544 Larocca, M. C...... 709 Lee, Hyun-Jung ...... 1067, 2198 Lee, Zang Hee ...... 1566 Laroche-Pierre, Stéphanie ...... 1369 Lee, Hojin ...... 399 Leers-Sucheta, Susan ...... 1221 Larochelle, Stéphane ...... 11 Lee, Hyun Ji ...... 591, 1229, 1400, 1562, Lefebvre, Daniel R...... 2203 Larre, Isabel ...... 871 1860, 1863, 1865 Leferovich, John ...... 299 Larrondo, Luis ...... 1593 Lee, Heun Jin ...... 849 Leffl er, Hakon ...... 2123 Larsen, Martin Røssel ...... 1519 Lee, Hyeong-Kyu ...... 881 Legant, Wesley R...... 313 Larson, Eric W...... 1603, 1919, 1920 Lee, Jayhun ...... 111, 2449 Leguia, Mariana ...... 1295 Larson, Jennifer R...... 2140 Lee, Jaemin ...... 1157 Lehesjoki, Anna-Elina ...... 1877, 1879 LaRusso, Nicholas F...... 455, 456, 457, Lee, Jae-Ho ...... 247, 1522, 1605 Lehman, William ...... 720, 1698 531, 532, 1393, 1816 Lee, Jen-Yi ...... 1042 Lehtinen, Maria ...... 1879 LaSalle, Janine M...... 1241 Lee, Jin Hak ...... 1829 Lei, Jason ...... 1249 Lasher, Leah ...... 632 Lee, Jong-Ho ...... 1566 Leibler, Stanislas ...... 2386 Lasheras, Juan C...... 419 Lee, Jongbin ...... 1594 Leikin, Sergey ...... 373 Lasiecka, Zofi a M...... 1978, 1979 Lee, Joon-Sung ...... 1853 Leitch, Carmen C...... 465, 1813 Lasse, Samuel ...... 343 Lee, Jungwoon ...... 201, 1866 Lekkas, Panagiotis ...... 723 Lassiter, Keyonica ...... 378 Lee, Jung-wha ...... 1399, 2041, 2042, 2043, Lekstrom, Kristen ...... 1329 Lastochkin, Elena ...... 757 2044, 2047, 2176 Lemaire, P...... 1615 Lathwood, Catherine ...... 92 Lee, Jeong Goo ...... 2164 Lemas, Dominick ...... 723 Latimer, Andrew ...... 886 Lee, Juliet ...... 417, 2324 Lemckert, Frances ...... 1676 Laue, Ernest D...... 1423, 2205 Lee, Jung Weon ...... 601, 881 Lemieszek, Marta K...... 54 Launay, Jean-Marie ...... 2022 Lee, Jeffrey D...... 793 Lemischka, Ihor R...... 206, 2447 Lauwaet, Tineke ...... 1631 Lee, James S. J...... 1942 Lemmon, Christopher A...... 2414 Lawler, Jack T...... 2399 Lee, James T...... 1895 Lemmon, Colleen R. M...... 1864 Lawrence, David S...... 1486 Lee, Kyuyoung ...... 1059 Lemmon, Sandra K...... 1090 Lawrencia, Carmel ...... 2444 Lee, Ki-Young ...... 1115 Lenardo, Michael J...... 2305 Lawson, Nathan ...... 1601 Lee, Kwanwoo ...... 1443 Lenne, Pierre-François F...... 999, 1610 Lawson, Shaneka S...... 1813 Lee, Kyu Shik ...... 1568, 1569, 1570, 1889 Lennon, Frances ...... 127 Lázaro-Diéguez, Francisco ...... 2104 Lee, Kuo-Chang ...... 1617 Lennon-Dumenil, Ana-Maria ...... 996 Lazo, John ...... 675 Lee, Kun-Chun ...... 485 Leonard, Michelle ...... 340, 354 Lazou, Kristell ...... 1222 Lee, Kyung S...... 15, 649 Leppa, Sirpa ...... 678 Le, Xiao Feng ...... 1359 Lee, Min-Jae ...... 1067 Leroux, Michel R...... 2082, 465 Le Bivic, Andre ...... 1673, 2123 Lee, Mi Nam ...... 1549 Lescure, Aurianne ...... 1728 Le Borgne, Roland ...... 2133 Lee, Marcus ...... 1622 Leshchyns’ka, Iryna ...... 1273 Leal, Leslie ...... 1177, 1178 Lee, Myeongwoo ...... 1805 Lesich, Kathleen A...... 980 Leaphart, Cynthia ...... 90 Lee, Ming-Shyue ...... 1858 Leslie, Julia E...... 1193 Leask, Andrew ...... 318, 1820, 1824 Lee, Mei-Yi ...... 1869 Lessard, Frederic ...... 816 Leavis, Paul ...... 1021 Lee, Man Ryul ...... 203, 228 Lessard, Mark D...... 1419, 2425 Lebedev, Nikolai ...... 1199 Lee, Mark H...... 61, 320 Lessick, Robert ...... 1755 Leber, Brian ...... 371, 806 Lee, Matt K...... 1557 Leterrier, J-F ...... 2349 LeBlanc, Andréa C...... 1369 Lee, Moo-Seung S...... 1327 Leto, Thomas L...... 1329, 2146 Lebofsky, Ronald ...... 12 Lee, Olivia ...... 863 Leuba, Sanford ...... 202 Lechtreck, Karl F...... 452 Lee, Pin-Tse ...... 122 Leube, Rudolf E...... 2362 LeClaire, Lawrence L...... 1026 Lee, Richard T...... 569 Leube, Rudolf L...... 2346 Lecuit, Thomas ...... 999, 1610, 1954, 2318 Lee, Sangyoon ...... 2094 Leung, Gordon ...... 561 Ledbetter, Mary L. S...... 1741 Lee, Seung H...... 1060 Leung, Louie ...... 438 Lee, Aih Cheun ...... 808 Lee, Sang M...... 240, 1760 Leung, Wilson ...... 1743 Lee, Bombi ...... 1186, 1187 Lee, Sang-Yun Y...... 1327 Levenson, Richard M...... 1206 Lee, Brian ...... 1817 Lee, SiuLan ...... 104 Levery, Steven B...... 2060 Lee, Changjin ...... 1240 Lee, Shiow-Ju ...... 1354 Levesque, Lyne ...... 129 Lee, Chieh-Hua ...... 1351 Lee, Seung-Ok ...... 457, 1393 Levi, Karen ...... 2169 Lee, Chia-Huei ...... 1537 Lee, Shin-Wha ...... 1406 Levi, Stephanie K...... 2005 Lee, Chang Sup ...... 1549 Lee, Sin-Ae ...... 601, 881 Levitan, Irena ...... 1421 Lee, Choogon ...... 1599 Lee, Seung Kyu ...... 1678 Levorse, John ...... 2447 Lee, Chih-Ying ...... 1642 Lee, Seung Joon ...... 1762, 1785 Levy, Jennifer R...... 500 Lee, Choong Ho ...... 537, 591, 686 Lee, Seung-Taek ...... 1856, 2279 Levy, Talia ...... 44 Lee, Chanjae ...... 942 Lee, Song-Eun ...... 238, 2449 Lew, Daniel J...... 1039 Lee, Chien C...... 1358 Lee, Soojin ...... 245 Lewellyn, Lindsay K...... 2251 Lee, Chi F...... 2316 Lee, Seong-Hee ...... 277 Lewis, Davina ...... 586 Lee, Dong-Won ...... 1101 Lee, Sun-Young ...... 680, 688 Lewis, Jacqueline S...... 459, 462 Lee, Dong-Hee ...... 171, 172, 179, 1397 Lee, Sung C...... 1143 Leystra-Lantz, Cheryl ...... 123 Lee, Dong-Seok ...... 147 Lee, Tae-Hoon ...... 147 Leyton, Denisse L...... 846 Lee, Dan ...... 2206 Lee, Tin-Lap ...... 211 Leyton, Lisette ...... 1810 Lee, Deokjae ...... 1060, 2302 Lee, Tracy ...... 744 Li, Bing ...... 2412 Lee, Doheon ...... 575 Lee, Tina H...... 164 Li, Cunxi ...... 1628, 2012, 2142 Lee, Dong Gun ...... 792 Lee, Ung ...... 1911 Li, Chunmei ...... 465 Lee, Eun kyung ...... 1170 Lee, William M...... 346, 347, 897, 2354 Li, Chuanfu ...... 692 Lee, Eun-Saem ...... 2279 Lee, William S. Y...... 398 Li, Dongmei ...... 1818 Lee, Eunjung ...... 575 Lee, Yun-Ah ...... 1528 Li, Fei ...... 2438 239 AUTHOR INDEX The American Society for Cell Biology 47th Annual Meeting December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

Li, GuoDong ...... 1175 Lin, Haifan ...... 2451 Liu, Yan N...... 821 Li, Guanlai ...... 1840 Lin, Ida ...... 1511 Liu, Yangfan ...... 1813 Li, Guangheng ...... 208 Lin, Jia-Ren ...... 2351 Liu, Yang ...... 2110 Li, Hongbin ...... 1054 Lin, Jen J...... 867 Liu, Yi ...... 1596 Li, Huihui ...... 2075 Lin, Kuan-Yin K...... 1809 Liu, Ying ...... 821 Li, He ...... 2178 Lin, Ming-shien ...... 1567 Liu, Yueyuan ...... 872, 884, 2276 Li, Hui ...... 2222 Lin, Shen ...... 761 Liu, Zhonghua ...... 650 Li, Hong L...... 2025 Lin, Wenbo ...... 1958 Livnat, Idit ...... 2265 Li, Jian ...... 1818 Lin, Wan-Hsin ...... 428 Llinas, Paola ...... 1696 Li, Jiangwei ...... 1897 Lin, Yu-Min ...... 1529, 2351 Lo, Cecilia W...... 1124 Li, Jingjing ...... 2237 Lin, Yi-Chia ...... 935 Lo, Denise ...... 907 Li, Jiang ...... 570 Lin, Yu C...... 2086 Lo, Frederick ...... 1375 Li, Juntao ...... 2150 Lince-Faria, Mariana P...... 1955 Lo, Jing-yi ...... 106 Li, Ju ...... 2152 Lind, Maria ...... 1283 Lo, Kai-Yin ...... 845 Li, Jun ...... 90, 823, 1002, 1003, 1671, 1973 Lindemann, Charles B...... 980 Lo, Kevin W...... 1658 Li, Lian ...... 1888, 1895, 1896, 1987 Linden, Rafael ...... 676 Lobert, Sharon ...... 2335 Li, Lei ...... 74, 2021 Linder, Stefan ...... 483, 1703 Lodge, Robert ...... 1991 Li, Lizhen ...... 39 Lindner, Robert ...... 295 Lodish, Harvey ...... 927 Li, Ma ...... 2394 Lindwasser, Wolf ...... 1091 Loerke, Dinah ...... 1096 Li, Michelle ...... 435 Ling, Qi ...... 504 Loew, Leslie M...... 474, 796, 1551, 1753, 1943 Li, Rong ...... 925, 1054, 1939 Ling, Yading ...... 1112 Logan, Clare V...... 460 Li, Shihe ...... 1670 Lingle, Wilma L...... 621 Loh, Y. Peng ...... 2078, 768 Li, Shaowei ...... 251 Link, Mia ...... 215 Lohia, Madhura ...... 64 Li, Shawn ...... 679 Links, Philip H...... 857, 2190, 2191 Loiodice, Isabelle ...... 18 Li, Simiao A...... 2121 Linstedt, Adam D...... 2002, 2003 Loiseau, Philippe ...... 1731 Li, Tsai-Kun ...... 1351, 1537 Lintz, Mario ...... 2053 Lomakin, Alexis Y...... 694, 715 Li, Wei ...... 1483 Lio, Pietro ...... 2205 Lombard, Michelle ...... 617 Li, Xinyan ...... 28 Liou, Jen ...... 9, 2431 Lombardi, Angela ...... 173 Li, Xun ...... 900 Lipatova, Zhanna ...... 2080 Lombardi, Mary Lou ...... 417, 2324 Li, Yuqing ...... 1376 Lippincott-Schwartz, Jennifer ...... 461, 803,1315, Loncarek, Jadranka ...... 644, 645 Li, Yuwen ...... 1562, 1863 2315, 2448, Longart, Marines V...... 1265 Li, Ye ...... 1943 Lisboa, Felipe ...... 554 Longhi, Silvia A...... 655 Li, Yubing ...... 630 Lisé, Marie-France ...... 964 Lopatto, David ...... 1743 Li, Zhenlin ...... 2340 Listenberger, Laura ...... 511 Lopes, Angela H...... 1322, 1323 Li, Zhigang ...... 426 Litchfi eld, David W...... 2149, 2156 Lopez-Robles, Erendira E...... 784 Li, Ze G...... 2025 Lithgow, Trevor ...... 1624 Lord, Matthew ...... 666 Li, Zhong-Juan ...... 1341, 1485 Littlefi eld, Ryan S...... 728, 735 Lorente Rodríguez, Andrés ...... 2108 Liakopoulos, Dimitris ...... 498 Littlepage, Laurie E...... 1582 Lorenz, H. Peter ...... 251 Lian, Jane B...... 1220 Liu, Aijun ...... 330 Lorenzi, Philip ...... 2441 Liang, Katherine ...... 735 Liu, Anguo ...... 77, 338 Loros, Jennifer ...... 1593 Liang, Yongheng ...... 2080 Liu, Andrea J...... 485 Losert, Wolfgang ...... 410, 411, 1640 Liao, Guoning ...... 928 Liu, Allen P...... 1682 Losev, Eugene ...... 1992 Liberali, Prisca ...... 298 Liu, Chun-Ju ...... 1171 Losick, Richard M...... 7 Liberty, Anne ...... 1350 Liu, Chengyu ...... 2307 Lotfi , Claudimara F. P...... 605 Licate, Lucila ...... 2325, 2326 Liu, Congrong ...... 349, 595 Loughlin, Rose ...... 25 Lichtenthaler, Stefan F...... 1104 Liu, Dan ...... 1325 Louie, Raymond J...... 1144 Lidofsky, Steven D...... 700 Liu, Fang ...... 80 Lovas, Gabor ...... 789 Lie, Pearl P. Y...... 346 Liu, Gang ...... 928, 1706 Love, Dona C...... 859, 1970 Lieb, Jason D...... 638, 1487 Liu, Hui-Lin ...... 646 Loveless, Timothy ...... 812 Lieleg, Oliver ...... 477 Liu, Haibo ...... 672 Lovell, Jon F...... 806 Lier, Audun J...... 957 Liu, Jason ...... 1370 Lowe-Krentz, Linda J...... 950, 1554 Lieu, Zi Zhao ...... 1995 Liu, Jin ...... 1430, 1526 Lowry, Peter ...... 1741 Liew, Michael ...... 1394 Liu, Ji-Long ...... 134, 1650 Loy, C...... 1606 Lignot, Jean-Hervé ...... 1909 Liu, Jianhua ...... 2150 Lozada, Michelle ...... 1912 Ligon, Lee ...... 894 Liu, J. P...... 2178 Lu, Chi-Wei ...... 1303 Likic´, Vladimir A...... 1624 Liu, Jianglan ...... 267 Lu, Congyi ...... 617 Liliensiek, Sara J...... 315 Liu, Li juan ...... 1115 Lu, Fei ...... 1542 Lilley, Kathryn S...... 1423, 2205 Liu, Libin ...... 259 Lu, Hongbin ...... 1436 Lilly, Walt W...... 638 Liu, Li ...... 65, 99, 1122 Lu, Jiuyi ...... 49 Lim, Chunghun ...... 1594 Liu, Miaoliang ...... 902, 1307 Lu, Jonathan T...... 1837 Lim, James ...... 470, 2379 Liu, Ningsheng ...... 1098 Lu, Pei-Yu ...... 582 Lim, Jieun ...... 682 Liu, Song Tao ...... 1499 Lu, Qun ...... 376, 867 Lim, Kim Buay ...... 1707 Liu, Shangxi ...... 1820, 1824 Lu, Rong ...... 2447 Lim, Kyu ...... 673, 674, 1560, 2155, 2290 Liu, Wenqiu ...... 1209 Lu, Shajia ...... 732 Lim, Liz K. B...... 1022 Liu, Wei ...... 1375 Lua, Bee Leng ...... 404 Lim, Roderick Y. H...... 842 Liu, Wenze ...... 187 Luan, Yuxia ...... 477 Lim, Sai K...... 1175 Liu, Wenqiu ...... 1918 Lubenec, Isabelle ...... 1818 Lin, Ann E...... 1335 Liu, Wendy ...... 323 Ludington, William B...... 983 Lin, Chen-Yong ...... 1858 Liu, Xiaofei ...... 940 Luduena, Richard F...... 1457, 2333 Lin, Clarissa ...... 374 Liu, Xiao I...... 2377 Lui, Wing Y...... 346, 347 Lin, Feng-Chi ...... 1529 Liu, Ya ...... 1325 Luini, Alberto ...... 2117, 298 240 The American Society for Cell Biology 47th Annual Meeting AUTHOR INDEX December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

Lukasiewicz, Kara B...... 621 Maibaum, Lutz ...... 1682 Marková, Vladimíra ...... 2337 Luna, Elizabeth J...... 1006, 1007, 994 Maier, Kerstin ...... 1668 Marks, David L...... 296 Lund, Linda M...... 891 Mains, Richard E...... 1088 Marks, Michael S...... 1981 Lundquist, Erik ...... 765 Maiti, Sankar ...... 1030 Marmo, Timothy P...... 2328 Luo, David Z...... 2399 Majumdar, Devi ...... 401, 2400 Marquette, Michele L...... 357, 1172, 1740 Luo, Haibei ...... 1318 Mak, Alan ...... 1481 Marquis, Kathleen ...... 121, 852, 853 Luo, Jin-Jun ...... 1885 Makarewich, Catherine A...... 177 Marr, Alexandra K...... 1403 Luo, Jianying ...... 668 Makhov, Alexander M...... 1014 Marra, Steven W...... 2203 Luo, Na ...... 867 Makino, Hatsune ...... 102 Marras, Salvatore ...... 2427 Luo, Ruihua ...... 1175 Makishima, Tomoko ...... 1134 Marriott, Gerard ...... 1932 Luo, Shouqing ...... 1451 Makova, Svetlana ...... 797, 1602 Marsden, Mungo ...... 815 Lupashin, Vladimir ...... 1998, 1999, 2000 Makushok, Tatyana ...... 1683 Marsh, Brad J...... 1192, 2422 Lupetti, Pietro ...... 987 Malakian, Karl ...... 1926 Marshall, Thomas W...... 431 Lupinetti, Jenna ...... 891 Malavarca, Richard ...... 1189 Marshall, Wallace F...... 983, 984, 985, 986, Lütolf, Matthias ...... 2452 Malave, Caridad ...... 1265 1426, 1427, 1431, 2423 Lutty, Gerard A...... 2364 Malayter, Dylan ...... 175 Marston, Daniel J...... 358 Luu, Nga ...... 519 Maldonado-Baez, Lymarie ...... 2092 Marteau, Clarisse ...... 1222 Luxton, G. W. Gant ...... 1252 Malhas, Ashraf N...... 159 Martiel, Jean-Louis ...... 1017, 1019, 1035 Luzes, Rafael ...... 1024 Malik, Asrar B...... 261, 1908 Martienssen, Rob ...... 2438 Lv, Xuelong ...... 1542 Malik, Harmit S...... 541 Martin, Adriana E...... 13 Ly, Kim Thien ...... 1339 Mallampalli, Rama K...... 1967 Martin, Brian M...... 272 Ly-Hartig, Thi Bach Nga ...... 1991 Mallareddy, Sandeep ...... 1543 Martin, Claire A...... 441 Lyerla, Timothy A...... 1747 Mallet, Jacques ...... 2022 Martin, Charles E...... 138 Lyle, Karen ...... 753 Mallozzi, Carolyn A...... 189 Martin, Finian ...... 607, 1766, 2013 Lynch, David T...... 1206 Malone, Christian J...... 1430 Martin, G. Steven ...... 577, 2139 Lynch, Gordon S...... 1676 Malowney, Andrew J...... 2259 Martin, Nora ...... 2215 Lynch, Jeffrey ...... 161 Man, Yan-gao ...... 330 Martin, Ona ...... 2394 Lynch, Patrick ...... 2405 Mandal, Shyamali ...... 1584 Martin, Scott E...... 2441 Lyons, Cherylann ...... 1348 Mandelkow, Eckhard ...... 752 Martin, Seamus J...... 800 Mandelkow, Eva Maria ...... 44, 752, 1454 Martin, V...... 1842 M Maness, Patricia F...... 2293 Martin, W. D...... 353 Ma, Hanhui ...... 1523 Mangin, Jean-Marin ...... 782 Martin-Belmonte, Fernando ...... 1614 Ma, Jimmy ...... 493 Mangoubi, Rami ...... 202 Martinez, Elisabeth D...... 103 Ma, Liang ...... 1928 Mani, Nina ...... 2014 Martinez, Juan C...... 1265 Ma, Li ...... 271 Mani, Timmy ...... 2067 Martínez, Susana E...... 2104 Ma, Tao ...... 1704 Manjunath, B. S...... 1449, 1463 Martínez-Turrillas, Rebeca ...... 50 Ma, Xuefei ...... 2307, 2310 Manlandro, Cara M. A...... 2010 Martins, Danielle ...... 1182 Ma, Xinghong ...... 928 Manley, Nancy R...... 1061 Martins, Joana ...... 1182 Ma, Yongqiang ...... 281 Mann, Dean ...... 77, 344 Maruta, Shinsaku ...... 94, 380, 381, 390, 395 Maar, Sandra ...... 658 Mann, Douglas L...... 2343 Maruyama, Ichiro ...... 2195 Mabuchi, Issei ...... 2367 Manna, Edward A...... 576 Marx, Alexander ...... 752 Mabuchi, Katsuhide ...... 954 Manning, Amity L...... 2208 Marx, Ruth ...... 1307 Macara, Ian G...... 64, 937, 1962, 1971 Manolea, Florin ...... 2106 Marzolo, Maria-Paz ...... 2101 Macarak, Edward J...... 690 Manoli, Irini ...... 518, 520 Masafumi, Yamada ...... 394 MacCarthy, Caitlin M...... 1470 Manry, Jeremy ...... 996 Masaki, Inagaki ...... 2351 Maccioni, Ricardo B...... 760 Manser, Edward ...... 404 Masedunskas, Andrius ...... 294 MacDonald, Elizabeth M...... 2162 Mansfi eld, James R...... 1206 Maselli, Andrew G...... 932 Macdonald, Paul M...... 220 Mansour, Hayam M...... 142 Mashukova, Anastasia ...... 2066, 2069 Machaca, Khaled ...... 2057, 2102 Manzo-Avalos, Salvador ...... 1294 Mason, Malcolm D...... 877 Machado-Santelli, Glaucia M...... 625, 1357 Mao, Suli ...... 1685 Massaro, Catherine M...... 2397 Machamer, Carolyn E...... 2009, 2077 Mao, Shu ...... 1932 Massimi, Paola ...... 130, 2131, 2170 Machida, Kazuya ...... 1873 Mao, Weiming ...... 1404 Masson, Justine ...... 777 Machuy, Nikolaus ...... 483 Mao, Yuxin ...... 1111, 2094 Masszi, Andras ...... 1758 Mack, David L...... 237 Mao, Yinghui ...... 2226 Mast, F...... 1625 MacKintosh, Frederick C...... 836, 935, 1636 Maradeo, Marie E...... 648 Mast, Fred D...... 827 Macosko, Jed C...... 704 Marcello, Marco ...... 1179 Mastronarde, David N...... 941, 2207, 2422 Maddala, Rupalatha ...... 430 Marchese, Adriano ...... 286 Masu, Kazuki ...... 742 Madden, Jennifer M...... 1741 Marco, Eugenio ...... 1501, 2235 Masumura, Takehiro ...... 181, 182 Maddox, Amy ...... 2251 Marcos, Séverine ...... 2301 Masyuk, Anatoliy I...... 1393, 1816, 455, 456, 457 Maddox, Paul ...... 1487, 1491 Marcus, Andrew H...... 703, 713 Masyuk, Tatyana V...... 1393, 1816, 455, 456, 457 Madeja, Zbigniew ...... 1697 Marcus, Stevan ...... 1141, 2160 Matenia, Dorthe ...... 1454 Mader, Christopher C...... 1873 Mardis, Elaine ...... 1743 Mathur, Anurag ...... 813 Madole, David ...... 493 Mardones, Gonzalo A...... 826 Mathur, Radhika ...... 1593 Madrid, Alexis S...... 840 Marelli, M...... 1625 Matos, Irina ...... 1506 Maeda, Hidekatsu ...... 380, 390 Maresca, Thomas J...... 1646 Matsubara, Hisahiro ...... 1362 Maeda, Kei ...... 776 Maric, Dragan ...... 789 Matsuda, Hiroki ...... 1056 Maeda, Nana ...... 508 Maric, Maja ...... 2166 Matsuda, Junichiro ...... 2048 Maeng, Yong-Sun ...... 1856 Mariggio, Stefania ...... 2117 Matsuda, Ryoichi ...... 1074, 1401 Magin, Thomas ...... 40 Marino, Christopher R...... 1977 Matsudaira, Paul ...... 851 Magnusson, Karl-Eric I...... 545, 1577, 1769 Marjomäki, Varpu ...... 298 Matsui, Chiyuki ...... 764 Maiato, Helder ...... 1506, 1955 Marko, John F...... 118 Matsui, Hiroko ...... 2019 241 AUTHOR INDEX The American Society for Cell Biology 47th Annual Meeting December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

Matsuki-Fukushima, Miwako ...... 81 McGee, Karen ...... 1613 Menko, A. S...... 340, 354, 366, 1388 Matsumoto, Shoko ...... 514 McGhee, Charles N. J...... 248, 908 Mennella, Vito ...... 832 Matsumura, Fumio ...... 2206 McGhee, Eva M...... 581 Menon, Anil ...... 345 Matsuo, Yasuhiro ...... 1141, 2160 McGrath, James ...... 797, 1602 Menon, Yoann ...... 1435 Matsushita, Kazuyuki ...... 1362 McGuckin, Colin ...... 242 Meraldi, Patrick ...... 1492, 1495, 1496, 2239 Matsushita, Kenji ...... 1838 McGuinness, Ryan ...... 561 Mercer, Andrew A...... 2163 Matsuura, Makoto ...... 741 McInnis, Brittney ...... 2160 Mercer, John A...... 964 Matsuzaki, Masunori ...... 514 McIntosh, J. Richard ...... 254, 941, 1645, 2207, 2213 Mercer, Rebecca ...... 1598 Matta, Leann ...... 1420 McKane, Melissa ...... 2368, 2371 Mercer, Sarah E...... 2158 Mattagajasingh, Ilwola ...... 151 McKay, Ronald ...... 237 Merdes, Andreas ...... 1435 Mattagajasingh, Subhendra N...... 151 McKee, Julie ...... 2321 Mérida, Isabel ...... 2104 Matter, Karl ...... 870 Mckee, Karen ...... 379 Merlino, Jessica ...... 213 Matthews, Ben ...... 1776 McKenna, Marshall ...... 1776 Merrick, Karl A...... 11 Matthews, Martha S...... 2203 McKenna, William ...... 907 Mersich, Akos T...... 1036 Mattheyses, Alexa L...... 670 McKenzie, F. E...... 1314 Merz, Alexey J...... 1090 Mattie, Floyd J...... 2297 McKenzie, Jenna ...... 2098 Merzvinskyte, Rasa ...... 545 Mattila, Pieta K...... 1681 McKeown, Caroline R...... 728 Mese, Gulistan ...... 909 Mattingly, Raymond R...... 772 McKeown-Longo, Paula J...... 1576 Meshorer, Eran ...... 1233 Mattjus, Peter ...... 825 McLaughlin, Patricia J...... 1364, 1365, Messenberg, Anat ...... 126 Mattos, Gabriele E...... 605 2153, 2187, 2188 Messmer, Angela F...... 433 Mattout, Anna ...... 35 McLean, Mark ...... 1221 Meszaros, Laura B...... 208 Matunis, Michael J...... 16, 573, 847, 1972 McMurray, Cynthia T...... 1882 Metalnikov, Pavel ...... 1052 Matuoka, Koozi ...... 1184 McNally, James G...... 152 Mettlen, Marcel ...... 1096 Matzat, Leah H...... 129 McNiven, Mark A...... 1027, 1094, 1097, 2007 Metzendorf, Christoph ...... 1283 Maughan, Dave ...... 719 McPherson, Peter S...... 1092, 1996 Metzger, Meredith B...... 1159 Maurice, Michéle ...... 2071, 2119 McQueen, Philip G...... 1314 Meyer, Tobias ...... 9, 1413, 2431, 2442 Maxfi eld, Frederick R...... 507 McStay, Gavin P...... 807 Meyers, Kathrin R...... 516 Mayer, Ashley ...... 1168 Mearow, Karen M...... 2017 Meyerzon, Marina ...... 714 Mayer, Bruce J...... 1873 Mears, Jason A...... 837, 1093 Meyhofer, Edgar ...... 833 Mayer, Ghislaine ...... 526 Mecum, Rebecca ...... 1871 Meyn, Liane ...... 1051 Mayer, Joshua A...... 2380 Medalia, Ohad ...... 35 Meza-Lamas, E ...... 784 Mayer, Mirjam ...... 1488 Medema, René ...... 717 Mezaki, Yoshihiro ...... 1218 Mayor, Satyajit ...... 533 Medina, Juan F...... 1393, 1816 Mezentseva, Nadejda ...... 230 Mazack, Virginia ...... 2179 Medina, Rafael ...... 1265 Mezghrani, Alexandre ...... 1130 Mazelova, Jana ...... 2079 Medley, Quint ...... 2320 Mian, I. S...... 2417 Mazucato, Vivian M...... 301 Mednieks, Maija I...... 501, 503 Mich-Basso, Jocelyn ...... 1756, 563 Mazumdar, Manjari ...... 108 Medrano, Vilma R...... 189 Michaelis, Susan ...... 1159 Mazzolini, Laurent ...... 1435 Medvedovic, Mario ...... 114 Michalak, Marek ...... 161, 229, 2034 McAinsh, Andrew D...... 1495, 1496, 2210, 2239 Mee, Joe ...... 1189 Michaud, Sebastien ...... 91 McAllister, Ryan G...... 1317, 1640 Meednu, Nida ...... 758 Michelot, Alphée ...... 1017, 1019, 1030 McArdle, Emmett ...... 607, 1766 Meehl, Janet B...... 1508 Michelotti, Julia M...... 561 McArthur, Andrew G...... 1631 Mège, René Marc ...... 361 Miera, Angel P...... 1306 McBeath, Elena ...... 1552 Megraw, Timothy L...... 1438, 1439 Mierke, Claudia T...... 939, 1713, 1802 McBeath, Rowena ...... 232 Mehl, Patrick M...... 1832 Miesenbock, Gero ...... 2404 McBride, Heidi M...... 2030 Mehlmann, Lisa M...... 918 Miettinen, Paivi J...... 678 McBryan, Jean ...... 2013 Mehra, Arun ...... 1593 Migeotte, Isabelle ...... 793 McCann, Colin P...... 411 Mehta, Simren ...... 922 Mikami, Hiroko ...... 1580 McCartney, Brooke M...... 189, 437 Meier, Kristen M...... 2400 Mikami, Toshiko ...... 1166 McCaughan, Geoffrey W...... 1084 Meili, Ruedi ...... 419 Mikels, Amanda J...... 1046 McClatchey, Andrea I...... 930 Meiners, Sally ...... 322 Mikerov, Anatoly N...... 1333 McClellan, Amie J...... 57 Meissirel, Claire ...... 786 Miki, Kazunori ...... 2124 McClelland, Sarah ...... 2210, 2239 Mejat, Alexandre ...... 560 Miliaras, Nicholas B...... 1433 McClugage, Samuel G...... 215 Melancon, Paul ...... 2106, 2112 Milijevic, Svetlana ...... 1065 McCollum, Dannel ...... 665 Melchior, Frauke ...... 717 Miller, Ann L...... 656 McCommis, K...... 989 Melkani, Anju ...... 2316 Miller, Elizabeth ...... 1144, 1160, 2107, 2109, 2118 McConchie, Heather F...... 1502 Melkani, Girish C...... 2316 Miller, Heidi ...... 1169 McConnell, Russell E...... 1685, 1686 Mellad, Jason A...... 1950 Miller, Kathryn G...... 1695 McCormick, Barrett Z...... 290 Mello, Maria Luiza S...... 1243 Miller, Mary E...... 2157, 2158 McCormick, William K...... 2081 Melloy, Patricia ...... 254 Miller, Paul M...... 809 McCrea, Heather J...... 1111, 2094 Melnick, Ari ...... 1603 Miller, Richard J...... 1130 McCulloch, Christopher A...... 1759, 2308 Melo, Edielle S...... 327 Miller, Rita K...... 758 McDaniel, Stephen ...... 113 Meltser, Max ...... 117 Miller, Stephanie A...... 2230, 2232 McDermitt, David ...... 238, 2449 Meltzer, Paul S...... 2410 Millet, Caroline A...... 1559 McDermott, John C...... 234, 2035 Mendez, Melissa G...... 2361 Milligan, Ronald A...... 1721 McDonald, Megan ...... 1741 Mendonsa, Rima ...... 252 Millman, Gregory W...... 1817, 1823 McDonald, W. H...... 667 Menendez, Guillermo ...... 2128 Milloz, Josselin ...... 795 McFall, Sally ...... 56 Menetrey, Julie ...... 1696 Mima, Shinji ...... 866 McFarland, David ...... 1756 Meng, Luke ...... 1712 Mimori-Kiyosue, Yuko ...... 764 McGaha, Lee A...... 737 Meng, Xinyi ...... 1958 Min, Jeong-Ki ...... 1856 McGarry, Thomas J...... 822 Meng, Yizhi ...... 880 Min Kyo, Jung ...... 543 McGee, Dennis W...... 1843 Mengistu, Meron ...... 950 Minami, Yasuhiro ...... 1479 242 The American Society for Cell Biology 47th Annual Meeting AUTHOR INDEX December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

Minc, Nicolas ...... 1038, 1516 Mohler, William A...... 249, 250 Morrison, E. E...... 744 Minden, Jonathan S...... 1064 Mohseni, Mori ...... 1708 Morse, Elizabeth ...... 1776 Ming-Jer, Tang ...... 592 Moitra, Prasun K...... 1374 Morse, Herbert C...... 2305 Mingle, Lisa A...... 1706 Moley, Kelle ...... 1083 Morton, Christine A...... 2285 Mingorance-Le Meur, Ana ...... 2289 Molino, Catilyn ...... 65 Moseley, Gregory W...... 846 Minshall, Richard D...... 260 Molitoris, Bruce A...... 923 Moseley, James B...... 1030, 1450, 2392 Mintz, Jason D...... 138 Moll, Lindsey N...... 225 Moser, Markus ...... 921 Mir, Mustafa ...... 851 Mollapour, Elahe ...... 1548 Mosher, Deane F...... 77, 338, 2399 Mirabito, Peter M...... 117, 1543 Möller, Dorothee ...... 2358 Moskowitz, David ...... 1741 Miraglia, Loren ...... 1598 Momotani, Ko ...... 2234 Moskowitz, Ivan ...... 1603 Miranda, Danielle ...... 1514 Monaco, Anthony P...... 1380 Moss, Anthony G...... 324, 1070 Mirny, Leonid ...... 1510 Moncman, Carole L...... 730 Moss, Joel ...... 1324 Mironov, Alexander A...... 2117 Mondal, Subhanjan ...... 427 Moss, Stephen E...... 504 Mirsaidov, Utkur M...... 851 Mondeh, Rhoda ...... 1189 Moss, Thomas ...... 816, 2018 Mishima, Toshiaki ...... 924 Mongan, Paul D...... 1281 Mostov, Keith ...... 88, 1614 Mishra, Viveka ...... 1226 Monier, Solange ...... 2133 Motoyoshi, Nomizu ...... 874 Misra, Saurav ...... 1161 Moninger, Thomas O...... 463 Mott, Rosalind E...... 1901 Misteli, Tom ...... 37,108, 116, 560, 1652, 2406 Moniz, David M...... 2271 Moua, Pangkong ...... 1736 Mitchell, Aaron ...... 990 Montalvo, Alexandra G...... 723 Moukhles, Hakima ...... 126, 329, 2061 Mitchell, David A...... 2138 Montano, Carolina ...... 116 Mountzouris, John ...... 1370 Mitchell, David R...... 988 Montecinos, Paola ...... 521 Moura, Pedro ...... 1622 Mitchison, Timothy J...... 1510, 1606, 2390 Monteil, Arnaud ...... 1130 Moutinho, José ...... 1182 Mithani, Aziz ...... 1212 Montgomery, Hillary A...... 1236 Moutinho-Pereira, Sara ...... 1506 Mitra, Deepali ...... 1209 Monzo, Kate ...... 1064 Mouw, Janna K...... 317 Mitra, Kasturi ...... 803 Monzo, Pascal ...... 1415 Mruk, Dolores D ...... 897 Mitrovic, Sandra ...... 2105 Moodie, Karen ...... 1307 Muchardt, Christian ...... 33 Mitsui, Toshiaki ...... 395 Moody, James ...... 1023 Mücke, Norbert ...... 2358 Mitsushima, Masaru ...... 652, 1782 Moody, Kristina ...... 1513 Mucsi, Istvan ...... 1758 Mittelmeier, Telsa M...... 1280 Moon, Randall T...... 1825 Mudgett, Mary Beth ...... 28 Miura, Kei ...... 265 Moon, Sung-Hwan ...... 203 Muecke, Norbert ...... 841 Miura, Mitsutaka ...... 1218 Moon, Seung J...... 240, 1760 Mueller, Hannah ...... 1488 Miyado, Kenji ...... 1826 Moons, Lieve ...... 786 Muench, Douglas G...... 766 Miyagawa-Tomita, Sachiko ...... 328 Moonsom, Seangdeun ...... 1330 Muentener, Kathrin ...... 1934 Miyakawa, Tsuyoshi ...... 1890, 1898 Moore, Ann L...... 700 Muhlrad, Andras ...... 2370 Miyake, Jun ...... 788, 1930 Moore, Carlene D...... 45, 1268 Mukai, Chinatsu ...... 1203 Miyake, Masato ...... 788, 1930 Moore, Judy ...... 1693 Mukherjea, Monalisa ...... 1696 Miyake, Tetsuaki ...... 234, 2035 Moore, Jeffrey K...... 1671, 1698 Mukherjee, Debarati ...... 1103, 655 Miyamoto, Tetsu ...... 1811 Moore, Shaunica ...... 193 Mukherjee, Suranjana ...... 1446 Miyares, Rosa L...... 1300 Moores, Carolyn A...... 1721 Mukhopadhyay, Jaba ...... 155 Miyasaka, Nobuyuki ...... 1851 Mooseker, Mark S...... 967, 1608, 1694 Mukhopadhyay, Somnath ...... 1773 Miyata, Keizo ...... 1197 Morales, Carlos R...... 1087 Mukhopadhyay, Somshuvra ...... 2088, 2089 Miyata, Masanori ...... 1379 Morales, Mary ...... 879 Mulder, Anke ...... 1721 Miyauchi, Akihiro ...... 1181 Moran, Catherine ...... 2341 Müller, Hannah ...... 1516 Miyazaki, Mieko ...... 1811 Morand, Stanislas C...... 2146 Müller, Mathias ...... 1984 Miyazawa, Kohtaro ...... 73 Moraru, Ion I...... 796, 1753 Muller, William J...... 356 Miyazawa, Yukimasa ...... 1362 Moreau, Flora ...... 1710 Muller-Reichert, Thomas ...... 631 Mizoguchi, Fumitaka ...... 1851 Morell, Robert J...... 1224 Müller-Taubenberger, Annette ...... 2245, 2377 Mizuguchi, Mineyuki ...... 1379 Moretão, Mariana ...... 1182 Mulligan, Timothy ...... 1302 Mizuno, Daisuke ...... 1636 Morfi ni, Gerardo ...... 2295 Mullins, James M...... 1832 Mizuno, Kensaku ...... 924 Morgan, David O...... 2217, 2217 Mullins, R. Dyche ...... 25, 471, 484, 636, Mizuno, Norikazu ...... 397 Morgan, Frank ...... 1551, 1943 849, 1026, 1634, 2391 Mizunoe, Shota ...... 574 Morgan, Garry P...... 1192, 2422 Munafo, Daniela D...... 1340 Mizunoe, Yoshimitsu ...... 1337 Morgan, Kathleen G...... 736, 1021, 1717 Mundinger, Tabea A...... 1801 Mizusawa, Hiroshi ...... 102 Mori, Hidetoshi ...... 1071, 1230 Munger, Karl ...... 581 Mizushima, Noboru ...... 253 Mori, Masahiro ...... 508 Munnamalai, Vidhya ...... 2291 Mizushima, Tohru ...... 571, 866, 1883, 2177 Morielli, Anthony D...... 1133 Munro, Edwin M...... 26, 1615 Mizutani, Kosuke ...... 1476 Morimoto, Richard I...... 56 Munson, Mary ...... 268 Mlodzik, Marek ...... 191 Morin, Nicole A...... 1466, 1840 Munteanu, E. Laura ...... 1452 Mo, Jung-Soon ...... 1568, 1569, 1570, 1889 Morin, Violeta ...... 2241 Munteanu, Laura ...... 1453, 19 Mo, Min ...... 2163 Morin-Leisk, Jeanne ...... 164 Murad, Joana M...... 588 Mobley, Stephen ...... 235 Moriscot, Anselmo S...... 327 Murakami, Kentaro ...... 1362 Mobley, William C...... 1880 Morishita, Rika ...... 1476 Murakami, Taichi ...... 524 Modregger, Jan ...... 2094 Morita, Shigeto ...... 181, 182 Muraki, Miho ...... 568 Moeller, Dorothee ...... 841 Moritz, Orson ...... 2079 Muramatsu, Shigenori ...... 89 Moerman, Donald G...... 738 Moriyama, Yoshinori ...... 571 Muramatsu, Takashi ...... 593 Mogami, Toshifumi ...... 491 Morozova, Nadya ...... 2080 Murat, Cirit ...... 1550 Mogilner, Alexander ...... 469, 484 Morphew, Mary K...... 2207, 2255 Murata, Hitoshi ...... 1366, 2197 Mohammad-Rafi ee, Farshid ...... 1679 Morre, D. James ...... 1142, 1147 Murata, Masayuki ...... 132 Mohan, Kavita ...... 1188 Morre, Dorothy M...... 1142, 1147 Murata, Takashi ...... 2393 Mohandas, Narla ...... 280, 348, 349, 350, Morris, Willie H...... 1534 Muresan, Virgil ...... 1387, 1732 594, 595, 1162, 1787 Morrison, Bethanie ...... 1770 Muresan, Zoia ...... 868, 1387, 1732 243 AUTHOR INDEX The American Society for Cell Biology 47th Annual Meeting December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

Muro, Silvia ...... 299 Nakatsuka, Michiko ...... 1166 Nguyen, Laurent ...... 1509 Murphy, Christopher J...... 315, 1195, 1413A Nakatsuka, Nobuaki ...... 182 Nguyen, Tam Quang ...... 551, 1334 Murphy, Catherine J...... 879 Nakaya, Tadashi ...... 1883 Nham, Sang-Uk ...... 1810 Murphy-Ullrich, Joanne ...... 338, 77 Nakayama, Kazuhisa ...... 1997 Ni, Li ...... 1876 Murray, John M...... 1321 Nakayama, Kei ...... 604 Nicastro, Daniela ...... 838 Murray, John W...... 1677 Nakayama, Masaaki ...... 1324 Nicholson, Bruce J...... 912 Murrells, Lindsay J...... 750 Nalavadi, Vijayalaxmi C...... 962 Nicholson-Dykstra, Susan M...... 1028 Murshid, Ayesha ...... 1991 Nalley, Kip ...... 152 Nicolas, Emmanuelle ...... 1812 Murtagh, Janice ...... 607 Nam, Anna ...... 83 Nicolau, J...... 513 Murthy, Kausalya ...... 661 Nam, Hyun-Ja ...... 1522 Nicoletti, Liliana M...... 2084 Murthy, Mamita ...... 1108 Nam, Hong Gil ...... 1595 Nie, Zgonzhen ...... 45 Musa, Shamsideen ...... 1670 Nam, Jae ...... 1193 Niederlein, Antje ...... 1984 Mushiake, Sotaro ...... 2124 Nam, Xue Hwa ...... 1561 Nielsen, Joseph A...... 789 Musil, Linda ...... 176 Namikata, Miyuki ...... 328 Nielsen-Preiss, Sheila M...... 1183 Musser, Siegfried ...... 843 Namkung, Joon ...... 1352 Niemisto, A...... 1625 Muthukrishnan, Gayatri ...... 393 Namkung, Jun ...... 2184 Nifoussi, Shanna K...... 1279 Muthukrishnan, Rajarajeswari ...... 1062 Napoletano, Silvia ...... 2013 Niikura, Yohei ...... 2212 Mutlu, G. M...... 1764 Narayan, Nisha ...... 2131 Nijati, Yashar ...... 1632 Muzykantov, Vladimir ...... 299 Narayan, Satya ...... 1859 Nikiforov, Yuri ...... 114 Myat, Monn Monn ...... 1010 Nargeot, Joël ...... 1130 Nikiforova, Marina ...... 114 Myers, Christopher ...... 378 Narita, Keishi ...... 466 Nikitin, Alexander ...... 1599 Myers, Dennis W...... 62 Narita, Masami ...... 1883 Niland, Brian P...... 1376 Myers, Kenneth A...... 2296 Narumiya, Shuh ...... 1883 Nilsson, Tommy ...... 1627 Myers, Kenneth R...... 1658 Naruse, Keiji ...... 1126 Nim, Satra ...... 262 Mykytyn, Kirk ...... 459, 462 Naslavsky, Naava ...... 1105 Ninfo, Vito ...... 2196 Myles, E Lewis ...... 1348, 1349 Nath, Avindra ...... 2364 Niño, Andrea ...... 527 Myles, Yvonne ...... 1348 Näthke, Inke S...... 92, 438 Nishida, Eisuke ...... 604 Myrna, Sabanero A...... 530 Natsume, Tohru ...... 253 Nishida, Hiroshi ...... 1527 Myzyri, Yrielda ...... 1747 Nau, Carla ...... 1011 Nishida, Teruo ...... 864, 896 Navakauskiene, Ruta ...... 545 Nishikawa, Shuh-ichi ...... 51 N Navara, Christopher ...... 563, 1756 Nishimori, Takanori ...... 1362 Na, Sungsoo ...... 1571 Navin, Klaus-Armin ...... 1311 Nishimura, Darryl ...... 463 Na, Youn ...... 1785 Nayak, Tania ...... 622, 626, 627, 2243 Nishimura, Koichi ...... 97 Nabavi, Noushin ...... 952 Neal, Rebekah A...... 215 Nishimura, Yukako ...... 653 Nabekura, Junichi ...... 1838 Nealey, Paul F...... 315, 1195 Nishita, Michiru ...... 1479 Nabi, Ivan R...... 126, 262,1473 Neamu, Florin ...... 1908 Nishiuchi, Ryoko ...... 1585 Nachury, Maxence ...... 464 Nebhan, Caroline A...... 2400 Nita-Lazar, Mihai ...... 370 Nadar, Vidya C...... 2296 Nechifor, Mihai ...... 689 Nitta, Ryo ...... 392 Nadezhdina, Elena S...... 694, 715, 1664 Nedergaard, Maiken ...... 263 Niu, Lili ...... 1929 Nag, Dilip K...... 1729, 2215 Needleman, Daniel J...... 1510 Niwa, Shinsuke ...... 1726 Nagao, Tomo ...... 507 Negrão, Rita ...... 1347 Nizami, Zehra F...... 134 Nagata, Koh-ichi ...... 1476 Neidt, Erin M...... 2389, 929 Nobrega, Derek ...... 1386 Nagayasu, Eiji ...... 1321 Neilsen, Paul ...... 1204 Nobuhisa, Umeki ...... 396 Nagel, Wolfgang E...... 1984 Neilson, Joel R...... 2439 Noda, Masaki ...... 1851 Nagele, Robert G...... 900 Nejsum, Lene N...... 2087 Noegel, Angelika ...... 427 Nagy, Attila ...... 966 Nelson, Christopher ...... 1358 Noei, Mehdi ...... 1065 Nagy, Henrietta ...... 2073 Nelson, Celeste M...... 1071, 2418 Noei, Reza ...... 1065 Nagy, James I...... 910 Nelson, D...... 1842 Noel, Geoffroy P...... 2061 Nagy, Stanislav ...... 835 Nelson, Jennifer ...... 1751 Noetzel, Tim ...... 751 Naka, Norifumi ...... 1469 Nelson, Jacquelyn L...... 1203, 2433 Nogami, Haruo ...... 2020 Nakada, Kazuto ...... 1890, 1898 Nelson, Lynne ...... 734 Noguchi, Tatsuhiko ...... 1695 Nakagami, Takuo ...... 1558 Nelson, W. James ...... 336, 947, 1428, 2087 Noguchi, Yoko ...... 2048 Nakagawa, Elly ...... 625 Nery, Flavia C...... 1376 Noh, Ok Jeong ...... 2028, 2029 Nakahata, Norimichi ...... 283 Neto, Catherine ...... 1350 Noji, Takehiro ...... 2130 Nakajima, Yuki ...... 1527 Nettikadan, S...... 1180 Nokes, Rita ...... 2129 Nakajima, Yuji ...... 2019 Neukirchen, Dorothee ...... 96, 1051 Nolen, Brad J...... 1025 Nakamoto, Tetsuya ...... 1851 Neumann, Aaron ...... 279 Nomachi, Akira ...... 1479 Nakamura, Ayumi ...... 2001 Neumann, Nicole G...... 1270 Nomizu, Motoyoshi ...... 875 Nakamura, Asako ...... 820 Neumann, Stephanie ...... 1104 Nomoto, Ann ...... 278 Nakamura, Fumihiko ...... 935 Nevalainen, Elisa M...... 921 Nomura, Fumimasa ...... 899 Nakamura, Hiroshi ...... 1838 Newcomb, William W...... 1199 Nomura, Hidehiro ...... 265 Nakamura, Rika ...... 611 Newell-Litwa, Karen A...... 1516, 1982 Noonan, Vikki ...... 370 Nakamura, Teruya ...... 1379 Newman, Stuart A...... 230 Norman, Ken R...... 738 Nakamuta, Shinichi ...... 775 Newmeyer, Donald D...... 801 Norris, Philip J...... 892 Nakane, Akio ...... 1341 Newnam, Gary P...... 562 Norris, Rachael P...... 918 Nakanishi, Mamoru ...... 265, 270, 305, 611 Newpher, Thomas M...... 49 Norstrom, Melanie F...... 835 Nakano, Kenzi ...... 2130 Newsome, Anthony L...... 889 Norton, John ...... 1649 Nakano, Tomoyuki ...... 1714 Ng, Michelle M...... 1044 Norvell, Amanda ...... 718 Nakao, Lia ...... 1182 Ngamukote, Sathaporn ...... 1069 Noske, Andrew B...... 1192, 2422 Nakashima, Misako ...... 1838 Ngezahayo, Anaclet ...... 915 Nossal, Ralph J...... 1089 Nakatani, Yuki ...... 374 Ngsee, Johnny K...... 2097 Notario, Vicente ...... 1470 244 The American Society for Cell Biology 47th Annual Meeting AUTHOR INDEX December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

Nothias, Fatiha ...... 2281 Ogura, Yuji ...... 375 Orth, Kim ...... 863 Nothwehr, Steven F...... 1994 Oguz, Fatma ...... 1068, 1227 Ortiz, Jennifer ...... 498 Notkins, Abner ...... 600 Oh, Chan-Seok ...... 138 Ortiz, Zachary ...... 1338 Novak, Igor L...... 422, 474, 701 Oh, Hye Jin ...... 1781 Orton, Kai ...... 56 Novak, Ivon T. C...... 1744 Oh, Jaehak ...... 1240 Osakada, Hiroko ...... 1256 Novak, Petr ...... 517 Oh, Joo Youn ...... 1829 Osaki, Luciana H...... 71 Novick, Peter ...... 967 Oh, Mi-Kyung ...... 1900 Osawa, Masaki ...... 1464 Novikova, Natalya ...... 135, 1653 Oh, Minsoo ...... 376 Oser, Matt ...... 1472 Novoradovskaya, Natalia ...... 1232 Oh, Seho ...... 1942 Oser, Matthew G...... 811 Novoradovsky, A ...... 1232 Oh, Sei-Ryang ...... 881 Osiak, Anna-Eleonor ...... 1703 Nowak, Roberta B...... 728 Oh, Wonil ...... 572 Osmanagic-Myers, Selma ...... 2363 Nozawa, Yoshinori ...... 1476 Ohashi, Kazumasa ...... 924 Osmani, Stephen A...... 622, 646 Nozomi, Umezu ...... 396 Ohashi, Tomoo ...... 1794 Osorio, Karen M...... 238, 2449 Nualart, Francisco ...... 780, 1139 Ohkura, Hiro ...... 748 Ostap, E. M...... 1687, 1688 Numata, Masayuki ...... 2136 Ohkura, Reiko ...... 491 Ostermeyer-Fay, Anne ...... 258, 511 Nunomura, Wataru ...... 1341 Ohnita, Ken ...... 1324 Ostler, Kelly R...... 1603 Nurse, Colin ...... 1382 Ohno, Kinji ...... 781 Ostlund, Cecilia ...... 38 Nusblat, Leora M...... 434 Ohsumi, Yoshinori ...... 799 Ostrovsky, Olga ...... 177, 2201 Nusse, Roel ...... 1046 Ohta, Yasutaka ...... 1759 Ota, Eiji ...... 1930 Nussenzweig, Andre ...... 116 Ohta, Yusaku ...... 924 Otani, Tomohiro ...... 1310 Nuth, Manunya ...... 2417 Ohtani, Azusa ...... 102 Otey, Carol A...... 481, 1414 Nyland, Lori ...... 719 Ohto-Fujita, Eri ...... 712 Otsuji, Yutaka ...... 1811 Nyporko, Alexey Y...... 2334 Ohwada, Shyuichi ...... 73 Otsuka, Shotaro ...... 1959 Nystrom, Erik ...... 1916 Ohyabu, Yoshimi ...... 1181 Ott, Carolyn M...... 461 Oiwa, Kazuhiro ...... 978, 979 Otter, Tim ...... 107, 219, 547, 1216 O Ojima, Koichi ...... 721 Ou-Yang, Daniel ...... 950 O’Brien, Carmel ...... 1189 Oka, Masahiro ...... 2040 Overbeek, Paul A...... 1309 O’Brien, John ...... 910 Oka, Tsutomu ...... 2179 Overlack, Nora ...... 1224 O’Brien, Lori ...... 955, 1249 Okada, Kyoko ...... 838, 2392 Owen, Katherine A...... 2274 O’Connell, Christopher B...... 645 Okada, Yasushi ...... 392 Ozawa, Yutaka ...... 102 O’Connell, Kevin F...... 620, 1433 Okamasa, Kasumi ...... 1951 Ozdemir, Anil ...... 224 O’Connor, Amber K...... 2085 Okamoto, M...... 590 Ozdilli, Kursat ...... 1068, 1227 O’Connor, Clare M...... 1748, 2385 Okbaok, Kim ...... 1356 Ozenberger, Bradley ...... 1375 O’Connor, Timothy P ...... 2289 Okiyoneda, Tsukasa ...... 574 Ozhovan, Sylvia ...... 1289 O’Donnell, John B...... 250 Okonta, Henry ...... 580 Ozono, Keiichi ...... 2124 O’Hara, Steven P...... 531, 532 Okoro, Cosmas ...... 1349 Oztan, Asli ...... 2125 O’Kane, Meghan ...... 1970 Okuhama, Nataly N...... 928 O’Neill, Shannon ...... 1075 Olah, Gabor ...... 1834 P O’Quinn, Ryan P...... 1499, 2229 Olandoski, Marcia ...... 1182 Pablo, Marquez J...... 1716 O’Reilly, Linda P...... 1305 Old, William M...... 623 Paccagnini, Eugenio ...... 987 O’Rourke, Brian ...... 1791 Oldenbourg, Rudolf ...... 637 Pacheco-Tovar, M. G...... 784 O’Rourke, Sean M...... 496 Oldham, Emily E...... 1741 Pack, Changi ...... 1946 O’Shaughnessy, Ben ...... 439, 473 Olenych, Scott ...... 444 Pagano, M...... 1180 O’Toole, Eileen T...... 1508, 2404 Olin, Michael ...... 564 Pagano, Richard E...... 296 O’Toole, George ...... 1328 Oliva, Joan V...... 823, 1973 Pagant, Silvere ...... 1160, 2118 Oakes, Patrick W...... 1466, 1840 Oliveira, Elaine C...... 327 Page, Carly ...... 2051 Oakley, Berl R...... 622, 626, 627, 1434, 1684, 2243 Oliveira, João ...... 1182 Page-McCaw, Andrea ...... 1338 Oakley, Christine E...... 627 Oliver, Constance ...... 301, 2084 Paik, Sang-Gi ...... 1561 Oas, Rebecca G...... 353 Olmo, Valerie N...... 890 Pajcini, Kostandin ...... 953 Oates, Jessica L...... 698 Olswang-Kutz, Yael ...... 86 Pajerowski, John David ...... 1251 Oba, Mariko ...... 1530 Olufemi, S. E...... 566 Pal, Prithwish ...... 1411 Ober, Raimund ...... 2424 Omary, M. Bishr ...... 41, 1390, 2347, Pal-Ghosh, Sonali ...... 872, 884, 2276 Oberdick, Ross ...... 1975 2348, 2352, 2353, 2365 Palacios, Isabel M...... 1731 Oberg, Jennifer C...... 2189 Omeh, Stephenia C...... 1185 Palanivel, Vikram R...... 2010 Oberhauser, Andres F...... 726, 1927, 1928 Omoe, Katsuhiko ...... 1341 Paliulis, Leocadia V...... 1508 Obom, Kristina ...... 1755 Ondo, Alejandro ...... 1164 Pallero, Manuel A...... 77, 338 Obr, Alison E...... 888 Onischenko, Evgeny A...... 840 Palm, Daniel ...... 1631 Obuse, Chikashi ...... 1493 Ono, Hisaya ...... 1341 Palmada, Nelson ...... 769 Ocbina, Polloneal J. R...... 793 Ono, Kanako ...... 1018 Palmer, Bradley M...... 719 Odaman, Hande ...... 1994 Ono, Shoichiro ...... 1016, 1018 Palmer, Jeffrey S...... 2374 Odde, David J...... 1508, 1639 Ono, Yasuko ...... 721 Paluh, Janet L...... 1511 Oegema, Karen ....992, 1432, 1491, 2141, 2251, 2254 Onuchic, Jose N...... 388 Pamonsinlapatham, Perayot ...... 1480 Oertli, Mathias ...... 1993 Opas, Michal ...... 229 Pampaloni, Francesco ...... 1179, 1460 Oetama, Ratna J...... 1420, 1421 Opoku-Ansah, John ...... 1555 Pan, Pingyue ...... 1275 Ogasawara, Emi ...... 1368 Ordoobadi, Alexander J...... 1738 Pan, Xiaoxiao ...... 2120 Ogasawara, Kiyomoto ...... 2020 Oriolo, Andrea S...... 2066, 2069 Panagopoulou, Panagiota ...... 2343 Ogawa-Goto, Kiyoko ...... 166 Orisme, Wilda ...... 763 Panaretos, Niki ...... 957 Ogle, Rebecca A...... 215 Orlichenko, Lidiya ...... 1870 Panavas, Tadas ...... 99 Ogle, Roy C...... 215 Orlov, Marika ...... 116 Pankov, Roumen ...... 1793 Ogret, Yeliz ...... 1068 Ormonde, Sue ...... 908 Pannell, Keith H...... 685 Ogura, Akiko ...... 508 Orth, J...... 1606 Pant, Harish C...... 600, 2350 245 AUTHOR INDEX The American Society for Cell Biology 47th Annual Meeting December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

Pante, Nelly ...... 1403, 1960 Paterski-Boujemaa, Rajaa ...... 1019 Peroutka, R. J...... 99 Pantel, Haddon ...... 289 Paterson, Andrew J...... 1404, 858 Perrier, Eric ...... 1222 Papalopulu, Nancy ...... 699 Pathak, Chander M...... 84 Perry, Dustin W...... 1543 Papanikou, Effrosyni ...... 1992 Pathak, Divya ...... 2443 Perry, Ryan J...... 183 Papin, Jason ...... 1214 Patorino, Sandra ...... 1555 Pesen, Devrim ...... 1788 Pappas, Leontios ...... 2185 Patra, Sukanya ...... 1536 Petcoff, Douglas ...... 2053 Papuga, Jessica ...... 1710 Patton-Vogt, Jana ...... 1141 Peterman, Erwin J. G...... 384, 389, 756, 834 Papusha, Almas ...... 1363 Paul, Aditya ...... 1033 Petersen, Heidi ...... 714 Paracchini, Silvia ...... 1380 Paul, Bindu ...... 1056 Petersen, Jennifer D...... 1725 Paradise, Summer ...... 2094, 2404 Paul, David ...... 918 Petersen, Shane ...... 1920 Paranhos-Zitterbart, Daniel ...... 432, 876, Paulin, Denise ...... 2340 Peterson, Alexander ...... 1572, 1941 1466, 1713, 1802 Paulson, James R...... 2204, 2246 Peterson, Andy ...... 458 Parekh, Sapun H...... 424, 425 Pavalko, Fredrick M...... 1771, 1780 Peterson, Johnny W...... 549, 1336 Parent, Carole A...... 410, 411, 412, 413, 810 Pavan, Bill ...... 2031, 2200 Petit, Brian ...... 2322 Parikh, Rishi B...... 495 Pavliv, Oleksandra ...... 2000 Petoukhov, Maxim ...... 486, 488 Parise, Leslie V...... 1408 Pawlicki, Anastasia L...... 1050 Petrie, Timothy A...... 1807 Park, Bok-Nam ...... 247 Pawlisz, Ashley S...... 241 Petroll, W. M...... 309 Park, Choon-Sik ...... 1406 Pawson, Tony ...... 499, 1052 Petrova, Youlia M...... 264 Park, Chung ...... 2305 Payette, Daniel J...... 1377 Petrs-Silva, Hilda ...... 676 Park, Chang-sik ...... 683 Paylor, Jeramiah J...... 1313 Petsoglou, Con ...... 908 Park, Chung S...... 1345 Payne, Gregory S...... 1980 Pettay, James ...... 1209 Park, Dae Hwi ...... 1518 Pazour, Gregory J...... 451, 453, 990 Pettit, Mark ...... 629 Park, Dongeun ...... 1762, 1785, 2302 Pearson, Chad G...... 971 Pettitt, Jonathan ...... 812 Park, Eun-Kyung ...... 276 Peckham, Lana A...... 1254 Petty, Chere ...... 186 Park, Eui-Soon ...... 683 Peckham, Michelle ...... 960, 961 Petukhova, Olga ...... 1577, 1769 Park, Hyo Eun ...... 1167 Peden, Andrew ...... 271, 1109 Pfeil, Douglas S...... 197 Park, Hae-Duck ...... 1560, 2155 Pedersen, Lotte B...... 991 Pfi ster, K. K...... 1658 Park, Hee-Sae ...... 1568, 1569, 1570, 1889 Pedersen, Roger ...... 1756 Pfl eghaar, Katrin S...... 36, 1946 Park, Hae-Joon ...... 2064 Pedersen, Stine F...... 1150 Phichith, Denis ...... 2314 Park, Hay-Oak ...... 677 Pederson, Thoru ...... 1523 Phil, Clark ...... 1188 Park, Hyo Y...... 240, 1760 Peeler, Margaret T...... 225 Philips, Ira ...... 8 Park, Ji-Hoon ...... 673, 674, 1560, 2155, 2290 Peeters, George ...... 546 Philips, Neena ...... 1754 Park, Jongsun ...... 1562, 1860, 1863, 1865 Pegoraro, Gianluca ...... 2406 Phillips, Carolyn M...... 1641 Park, Jong Kuk ...... 1872 Peifer, Mark ...... 78, 331, 332, 1424 Phillips, Robert ...... 1190 Park, Jong-Il ...... 673, 674, 1560, 2155, 2290 Peitsch, Wiebke K...... 1703 Philp, Nancy J...... 2267 Park, Jung-Eun ...... 601, 649 Pekny, Milos ...... 39 Phirke, Prasad ...... 447 Park, Joshua J...... 2078 Peleg, Horowitz M...... 1893 Phu, Cam ...... 1980 Park, Ken ...... 1124 Pelle, Dominic W...... 980 Piano, Fabio ...... 2046 Park, Kyeong Ah ...... 1562, 1860, 1863, 1865 Pellman, David ...... 23, 640, 926, 1719 Piao, Longzhen ...... 1562, 1860, 1863 Park, Kwang-Hyun ...... 1988 Pemberton, Lucy F...... 1236, 2411 Piasecki, Brian P...... 972 Park, Minjong ...... 699 Pendergast, Ann Marie ...... 430 Pichot, Christina S...... 2137, 467 Park, Sang woong ...... 1127 Pendrak, Michael L...... 529, 1855 Pickard, Gary E...... 910 Park, Sang-Min ...... 1334, 1360 Peng, Jun ...... 727, 734 Pickens, James ...... 1149 Park, Seung-Kiel ...... 673, 674, 1560, 2155 Peng, Qian ...... 1630 Pickin, Rebecca R...... 136 Park, Sun-Yi ...... 1605 Peng, Zi ...... 1958 Picou, Theodore J...... 1317 Park, Seon Ho ...... 1872 Pennington, Kathleen A...... 2016 Piekny, Alisa J...... 17, 2253 Park, Seon-Joo ...... 1900 Penzes, Peter ...... 964 Piel, Matthieu ...... 996, 1683 Park, Seok Hee ...... 544, 1170 Pepperkok, Rainer ...... 1991 Pielage, Jan ...... 2397 Park, So Hyun ...... 792 Peprah, Emmanuel ...... 1372 Pierce, Daniel ...... 1025, 1099, 1741 Park, Yong Hwan ...... 2028, 2029 Perbal, Bernard ...... 2194 Pierce, Heather L...... 1499 Parkash, Jai ...... 1129 Perdomo, Sandra ...... 1178 Pierini, Lynda M...... 507 Parker, Erin L...... 2156 Pereira, António J...... 1506 Pietangelo, Antonello ...... 2353 Parker, Jonathon J...... 1545 Pereira, Maria ...... 2209 Piffath, Crystal L...... 1031 Parks, Robin J...... 2030 Pereira-Leal, José B...... 1422 Pigino, Gaia ...... 987 Parra, Marilyn ...... 350 Perenlei, Molor E...... 2160 Piispanen, Amy E...... 1343, 1586 Parris, Kevin ...... 1926 Perera, Imara Y...... 1563 Pike, Alexander C...... 2278 Parsons, J. T...... 2274 Perera, Rushika M...... 829 Pilch, Paul ...... 259 Parsons, Maddy ...... 21 Peresie, Jennifer ...... 2051 Piludu, Marco ...... 503 Parton, Rob ...... 1676 Perez, Edith A...... 895 Pimentel, Silvia B...... 319 Pasapera-Limon, Ana ...... 814 Pérez, Fernando ...... 1139 Pinaev, George P...... 1577, 1769 Paschal, Bryce M...... 1876, 1947 Perez, Franck ...... 1728 Ping, Liu ...... 1707 Passaniti, Antonino ...... 77, 338, 2273 Pérez-Gallardo, Rocío V...... 1294 Ping, Yueh-Hsin ...... 536 Pastor, M. C...... 2192 Perez-Martinez, Xochitl ...... 1288 Pinsky, Benjamin ...... 2220 Patel, Gopal ...... 1603 Pérez-Otaño, Isabel ...... 50 Pinto, Alex ...... 2178 Patel, Kunal ...... 539 Peris, Leticia ...... 2330 Pinto, Belinda S...... 1248, 2360 Patel, Prerna C...... 1849 Perkins, Archibald ...... 161 Pinto, Yuval ...... 2307 Patel, Priyanka L...... 608 Perkins, Edward M...... 2092 Piras, Monica I...... 503 Patel, Shruti ...... 193 Perkins, Guy ...... 2212 Pires, Francisco S. M...... 1395 Patel, Snehal B...... 135, 1653 Perlson, Eran ...... 1659 Pirone, Dana M...... 233, 2419 Patel, Tushar ...... 1712 Perng, Ming Der ...... 1371 Pitman, Jena ...... 1594 Patel-King, Ramila S...... 489, 991 Pernodet, Nadine ...... 880 Pitonzo, David ...... 1156 246 The American Society for Cell Biology 47th Annual Meeting AUTHOR INDEX December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

Pixley, Fiona J...... 1485 Prekeris, Rytis ...... 271, 1109, 2079, 2253 Rafalska-Metcalf, Ilona ...... 1234 Plafker, Kendra S...... 2165 Prentice-Dunn, Hannah ...... 1414 Rafelski, Susanne ...... 2423 Plafker, Scott M...... 2165 Presley, John F...... 1991, 2112 Raff, Jordan W...... 1425 Plamann, Michael D...... 493 Prestifi lippo, Juan Pablo ...... 287 Raffaniello, Robert ...... 1114 Plant, Anne L...... 310, 1173, 1572, 1797, 1941 Preston, Gail M...... 1212 Rafferty, Brian J...... 1843 Plastino, Julie ...... 2260 Price, Jessica ...... 1891 Rafi q, Sarwish ...... 1114 Platt, Fran M...... 825 Price, Meredith H...... 634 Raghavan, Srivatsan ...... 313 Platt, Jeffrey L...... 1338 Prieto, Susana ...... 2241 Ragnauth, Cassie ...... 1651 Platz, Barbara ...... 1191 Prinz, William ...... 163, 1970 Rahajeng, Juliati ...... 1105 Plotnikova, Olga ...... 1812 Proia, Michael ...... 1931 Rahdar, Meghdad ...... 1531 Plummer, Howard K...... 1857 Pronk, Sander ...... 1682 Raheem, Olayinka ...... 566, 567 Plutz, Mathew ...... 110, 2408 Prosser, Derek C...... 2097 Rahimtula, Masuma ...... 2017 Poczobutt, A. M...... 590 Proto, E...... 503 Rahn, Kristen A...... 1364 Pogliano, Kit ...... 3 Przybylo, Jennifer A...... 888 Rai, Reeta ...... 1319 Poirier, Francoise ...... 2123 Ptak, Christopher ...... 1965 Rai, Reena R...... 862, 1533 Poirier, Guy ...... 91 Ptaszynska, Malgozata M...... 1855 Rai, Vivek ...... 598 Pokrovskii, Maria ...... 731 Pu, Rongsun ...... 193 Raimondi, Andrea ...... 2404 Pokusa, Jacqueline ...... 164 Puertollano, Rosa ...... 1975, 2114 Rajagopal, Chitra ...... 1088 Polak, Martin ...... 1095 Pugh, Raymond ...... 1554 Rajagopalan, Vidyalakshmi ...... 490 Poland, Sharon F...... 857, 2189, 2191 Pukkila, Patricia J...... 6, 638 Rajalingam, Dakshinamurthy ...... 2183 Polevoy, Gordon ...... 982 Punj, Vasu ...... 2002 Rajendran, Lawrence ...... 1383 Polishchuk, Elena V...... 825, 2117 Punzi, Dario ...... 173 Rallis, Andrew S...... 194 Polishchuk, Roman S...... 825, 1819, 2117 Purinton, Gina ...... 765 Ram, Sripad ...... 2424 Polka, Jessica ...... 1499 Pushkareva, Marina A...... 893 Ramabhadran, Vinay ...... 1037 Pollard, Thomas D...... 1025, 1033, 2247 Putney, James W...... 1131, 1132 Ramalingam, Nagendran ...... 418, 2377 Polleux, Franck ...... 43, 1053 Putterill, Joanna ...... 1595 Raman, Venu ...... 1791 Polusani, Srikanth R...... 912 Pypaert, Marc ...... 273 Ramaswami, Sitharam ...... 1862, 1867 Pomerance, Andrew ...... 1640 Pytel, Peter ...... 1603 Ramirez, Omar A...... 773 Pommier, Yves ...... 2441 Pyun, Kwang-Ho ...... 1186, 1187 Ramlal, Nishant ...... 1065 Ponce, Arturo ...... 865 Ramnarayanan, Sai P...... 2122, 2135 Ponik, Suzanne M...... 1757 Q Ramos, Joe W...... 1555 Ponissery Saidu, Samsudeen ...... 783 Qadota, Hiroshi ...... 737, 738, 739 Ramos-Castaneda, Jose ...... 535 Pons, Jennifer ...... 617 Qi, Hongying ...... 651 Ramsey, S...... 1625 Pontoriero, Pasquale ...... 193 Qi, Jie ...... 917, 1208, 2174 Rand, Eyal ...... 227, 1233 Poon, Vivian Y. N...... 47 Qi, Yuanming ...... 594 Randall, William R...... 1004 Pope, Lisa H...... 118 Qiang, Liang ...... 2294 Randazzo, Paul A...... 45, 2079, 2279 Pope, Robert K...... 931, 1909 Qiao, Huihong ...... 554 Randhawa, Paramjeet K...... 342 Porat-Shliom, Natalie ...... 304 Qin, Chunbo ...... 507 Rando, Oliver ...... 1494 Pores-Fernando, Arun T...... 1118 Qin, Yi-Xian ...... 880 Rangel, Marisa ...... 1357 Porter, Andrew C. G...... 16 Qing, Yi ...... 62 Ranish, Jeffrey ...... 1497 Porter, Iain M...... 1496, 2210 Qiu, Yuanyuan ...... 161, 229 Rankin, Sherri L...... 2017 Portie, Ken ...... 1153 Qu-Petersen, Zhuqing ...... 209 Rao, Anjana ...... 553 Posch, Markus ...... 1496 Quadir, Razi ...... 550 Rao, Subba Gangi Setty ...... 1981 Postow, Lisa ...... 115 Quan, Yu ...... 1958 Rao, Trisha ...... 2256 Potapova, Tamara A...... 636, 2151 Quest, Andrew F. G...... 1810 Rao, Vasantha P...... 430 Poteryaev, Dmitry ...... 1520 Quinlan, Margot E...... 25 Rao, Yong ...... 1986 Poulain, Fabienne E...... 2303 Quinlan, Roy A...... 1371, 1798 Rapoport, Tom A...... 852, 853 Pourmand, Nader ...... 1207 Quinn, Christopher C...... 197 Raposo, Alexandre S. F...... 1425 Pouton, Colin W...... 846 Quinones, Gerri ...... 894 Raposo, Graça ...... 269, 831 Powell, Jeralyn ...... 1348 Quintero, Omar A...... 957 Rappoport, Joshua Z...... 2095 Powell, Rick ...... 1209 Quintero-Monzon, Omar ...... 1015 Rasenick, Mark M...... 2338, 2435 Powers, Andrew F...... 755, 1445, 1517 Quyn, Aaron ...... 92 Rash, John E...... 910 Powers, James A...... 1447 Rasmussen, Maria ...... 1150 Powers, Sara Lawrence ...... 1234 R Rasoul, Bareza A...... 1658 Pozzo-Miller, Lucas ...... 1268, 45 Raabe, Isabel ...... 943 Rassi, James G...... 502 Pozzuto, Maria ...... 1485 Raaka, Bruce M...... 217 Rath, Satyajit ...... 533 Prabhakar, Savita ...... 1835 Rabinovitch, Marlene ...... 1478 Rath, Uttama ...... 651, 2216 Prabhat, Prashant ...... 2424 Rachfal, Amy ...... 2194 Rathaur, Sushma ...... 1319 Prabhu, Saileta ...... 1358 Rachlin, Andrew S...... 481 Raupach, Carina ...... 432, 876, 1713, 1802 Prabhu, Yogy ...... 826 Rachubinski, Dorian A...... 184 Ravaille-Veron, Michèle ...... 2281 Pradhan, Sunil ...... 1320 Rachubinski, Richard A...... 183, 184, 695, 827, 1625 Raver, Charles ...... 83 Pradhan, Suraj ...... 1594 Raciti, Gregory Alexander ...... 173 Rawle, Robert ...... 2121 Prasad, Amit ...... 1320 Racz, Bence ...... 49 Ray, Animesh ...... 1631 Prasad, Kondury ...... 1089 Rada, Balazs ...... 1329 Ray, Brianne J...... 2274 Prasad, Kashi N...... 1320 Raddatz, Katy ...... 727 Ray, Pampa ...... 837, 1093 Pratt, Joanne C...... 2168, 2169 Rademakers, Suzanne ...... 454 Ray, Sutapa ...... 148 Pratt, Stephen J...... 407 Radisky, Derek C...... 888, 1870 Ray, Samriddha ...... 665 Pratto, Florencia ...... 119 Radke, Michael H...... 734 Raycroft, Maury ...... 1490 Pravatta, Henrique ...... 325 Raemaekers, Tim ...... 749 Raynaud, Francoise ...... 1480 Predescu, Dan N...... 261, 1908 Raevskaya, Natalia M...... 1664 Razafsky, David S...... 493 Predescu, Sanda A...... 261, 1908 Rafailovich, Miriam ...... 880 Reagan, Jerry W...... 1990 247 AUTHOR INDEX The American Society for Cell Biology 47th Annual Meeting December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

Reaven, Eve ...... 278 Ries, Jonas ...... 1515 Rolle, Isaiah ...... 45 Rebelatto, Carmen L. K...... 1182 Riezman, Howard ...... 824 Rollenhagen, Christiane ...... 468 Rebowski, Grzegorz ...... 486, 488 Rikhy, Richa ...... 2315 Rollins, Janet ...... 982 Rebustini, Ivan T...... 378 Rinaldo, Francesca M...... 1338 Rolls, Melissa M...... 2297, 2300 Recinos, David A...... 2329 Rines, Dan ...... 1440 Romano, Julia D...... 525 Reck-Peterson, Samara L. ...492, 494, 967, 1663, 1665 Ringhoff, Danielle N...... 762 Romanova, Julia M...... 893 Redick, Sambra D...... 1429 Rinn, John ...... 967 Romanska, Hanna M...... 218 Redinger, Carrie ...... 563 Risca, Viviana I...... 471 Romanyuk, Andrey V...... 562 Redowicz, Jolanta M...... 938 Rishi, Arun ...... 709 Romer, Lewis H...... 1777, 2414 Redowicz, Maria Jolanta ...... 1697 Rismanchi, Neggy ...... 2114 Römer, Winfried ...... 831 Reed, Nate A...... 833 Ritter, Brigitte ...... 1092 Romero, Roberto ...... 2198 Reed, Sarah A...... 2152 Ritzenthaler, Jeffrey D...... 916 Romijn, Edwin P...... 1431, 1631 Reed, Shawna C. O...... 31 Riuzzi, Francesca ...... 2196 Rompolas, Panteleimon ...... 991 Regan, John W...... 1384 Rivard, Christopher J...... 1128, 1966 Roof, David M...... 1719 Régnault, Beatrice ...... 33 Rivas, Cecilia ...... 2031 Roovers, Kristin ...... 603 Rehfeldt, Florian ...... 243, 312, 316 Rivera, Linette ...... 1344 Roque, Helio D...... 750, 941 Rehm, Armin ...... 557 Rivera Rosado, Leslie ...... 1808 Rosales, Carlos ...... 198 Reich, Reuven ...... 597, 1875 Rivero, Francisco ...... 427 Rosales, Jesusa L...... 1115 Reichert, Nina ...... 2040 Rizk, Rania S...... 1447 Rosas, Javier ...... 2106 Reichl, Elizabeth M...... 1635, 2255 Roadcap, David W...... 596 Rosasco-Nitcher, Sara E...... 2219 Reichner, Jonathan S...... 1466, 1840 Robatzek, Silke ...... 29 Rose, Kenneth ...... 1449, 1463 Reifert, Jack ...... 1449 Robert, Phair ...... 116 Rose, Lesilee S...... 1518 Reiner, David ...... 1631 Robert, Skibbens V...... 648 Rose, Mark D...... 254 Reiner, Orly ...... 44, 2265 Roberts, David D...... 1855, 529 Rosemblatt, Mario ...... 996 Reinicke, Karin ...... 1139 Roberts, Dave M...... 342 Rosen, Jeff ...... 2185 Reinke, Michelle K...... 1745 Roberts, Thomas M...... 2257, 2258, 2259 Rosenbaum, Joel L...... 14, 987, 990 Reis, Rita ...... 2224 Roberts-Galbraith, Rachel H...... 667 Rosenblatt, Jody ...... 1613 Reiser, Jochen ...... 1095 Robertson, Brian W...... 1581 Rosenbloom, Alyssa ...... 1295 Reisler, Emil ...... 2370, 2375 Robin, F. P...... 1615 Rosenfeld, Steven S...... 1415 Reiter, Stefanie ...... 384 Robinson, Christopher T...... 879 Rosentein, Jeffrey ...... 2014 Relucio, Jenne ...... 1767 Robinson, Douglas N...... 415, 664, 1635, 2255 Rosenwald, Anne G...... 1741, 2010 Remy, Marie Helene ...... 1435 Robinson, Kelsi ...... 275 Rosivall, Laszlo ...... 1758 Ren, Gang ...... 256 Robinson, Michael L...... 452 Ross, Jeffrey J...... 321 Ren, Haiyun ...... 1700 Robinson, Nerissa ...... 1691 Ross, Jennifer L...... 839, 1659, 1660 Ren, Wei ...... 684 Robles, Laura J...... 145 Rossier, Olivier M...... 813 Ren, Yixin ...... 1635, 2255 Robson, Richard M...... 2340 Rosu-Myles, Micheal ...... 237 Renner, Annelies ...... 1435 Rochman, Mark ...... 2409 Roth, Bryan L...... 2435 Rericha, Erin C...... 410, 411, 1640 Rock, Ronald S...... 835 Roth, Daniela M...... 846 Rescher, Ursula ...... 1110 Roden, Julie ...... 28 Rotolo, Sean ...... 1281 Retamal, Mauricio A...... 1125 Rodenberg, Eric J...... 1771 Rougier, Natalie ...... 1582 Retegui, Lilia A...... 655 Rodgers, William A...... 2062 Rouhani, F. N...... 1232 Rettori, Valeria ...... 287 Rodionov, Vladimir I...... 24, 694 Rout, Michael P...... 1626 Reuss, Luis ...... 1125, 1143 Rodríguez-Rodríguez, Javier ...... 419 Roux, Aurelien ...... 1140 Reuter, Ursala ...... 40 Rodrigues-Martins, Ana P...... 2395 Rowland, Steven D...... 293 Revelo, Natalia ...... 1177 Rodriguez, Andrianna ...... 1511 Roy, Craig R...... 2120 Reverdatto, Sergei ...... 1630 Rodriguez, Alexis J...... 22, 334, 2050 Royou, Anne ...... 1503 Rexer, Charles H...... 1654 Rodriguez, Hector M...... 731 Roysam, Badri ...... 803 Reyes, Juan F...... 1893 Rodriguez, Varenka ...... 2262 Rozario, Tania ...... 311 Reynhout, James ...... 913 Rodriguez-Boulan, Enrique ...... 2126 Rozenberg, Gabriela ...... 1803 Reynolds, Albert B...... 339, 353, 356, 367 Rodriguez-Collazo, Pedro ...... 202 Rubenstein, Peter A...... 2368, 2371, 2375 Reynolds, Mattew R...... 1893 Rodríguez-Medina, José R...... 2312 Rudel, Thomas ...... 483 Rezania, Vahid ...... 150, 1457 Rodríguez-Quiñones, José F...... 2312 Rüder, Constantin ...... 557 Rhayem, Joelle ...... 2434 Roegiers, Fabrice ...... 188, 2300 Rudner, David Z...... 121, 852, 853 Rhee, Kunsoo ...... 1442, 1443 Roeper, Jens-Christian ...... 1612 Rudrabhatla, Parvathi ...... 2350 Rhee, Sangmyung ...... 307 Roepstorff, Peter ...... 2209 Ruiz, Sami A...... 233 Rho, Jaerang ...... 683 Rogasevskaia, Tatiana ...... 257 Ruiz de Almodovar, Carmen ...... 786 Rhoden, John ...... 420 Rogers, Gregory C...... 1424, 2216 Rukavishnikov, A...... 1842 Rhrzepetskiy, Yuriy ...... 938 Rogers, Jason ...... 146 Runnels, Loren W...... 2275 Ricca, Benjamin L...... 835 Rogers, Stephen L...... 1424 Rusan, Nasser M...... 1424 Rice, Sarah E...... 391 Roggero, Vincent R...... 1964 Rusche, Laura ...... 2405 Richardson, Brian C...... 2001 Roh, Da-eun ...... 1399, 2041, 2042, 2043, Rush, Haley K...... 1990 Richardson, Brian E...... 2121 2044, 2047, 2176 Russel, Deborah E...... 169 Richie, Christopher T...... 1520 Roh, Minna ...... 1046, 2263 Russell, Alan ...... 1025 Richmond, David L...... 1682 Rohlfs, Meino ...... 418, 2377 Russell, Paul ...... 315, 1195 Richterová, Vera ...... 2337 Rohrer, Jack ...... 1086, 1993 Russell, Travis ...... 2321 Rico, Arantza ...... 1212 Rojas, Angela ...... 527, 528 Russo, Jose ...... 1243 Ridge, Karen M...... 1637 Rojas, Adriana L...... 1108 Russo, Patricia ...... 1243 Riebeling, Christian ...... 1564 Rojas, Diana ...... 1177 Rusterholtz, Karl ...... 1156 Rieber, Manuel ...... 687 Rojas, Raul ...... 1108 Rustgi, Anil K...... 72 Rieder, Conly ...... 644 Rojas, Sebastian ...... 760 Rutherford, Suzannah ...... 58 Riedl, Julia ...... 96 Roland, Jeremy ...... 1019 Ryan, A. Jacqueline ...... 1741 248 The American Society for Cell Biology 47th Annual Meeting AUTHOR INDEX December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

Ryan, Sean P...... 2074 Salisbury, Jerrod J...... 878 Satoh, Yoh-ichi ...... 69, 79, 741, 742 Ryan, Timothy A...... 2404 Salisbury, Jeffrey L...... 621 Satoshi, Nishimura ...... 509 Rybin, Andrew ...... 1486 Salleng, Kenneth ...... 867 Saudou, Frederic ...... 1509, 1607 Ryoma, Ohi ...... 1510 Salman, Shaima ...... 1382 Saunders, Philippa ...... 2023 Ryozo, Nagai ...... 509 Salminen, Marjo ...... 1681 Saunders, William S...... 659, 662, 675, 1730 Ryu, Jeongeun ...... 683 Salmon, Edward D...... 1428, 1498, 1499, 1506, Sawada, Takashi ...... 1789 Ryu, Sung Ho ...... 1549 1508, 1646, 2227, 2229 Sawyer, Jessica K...... 78, 331 Ryusaku, Deguchi ...... 2049 Salomao, Marcela A...... 1162, 280 Saxena, Anurag ...... 2190 Saluja, Daman ...... 154, 1525 Saxton, Michael J...... 1213 S Salvesen, Guy S...... 807 Saxton, William M...... 1736 Saarikangas, Juha ...... 1681 Samadi, Abbas ...... 1817, 1823 Saya, Hideyuki ...... 158, 1605 Saavedra-Molina, Alfredo ...... 1294 Samanta, Manoj ...... 224 Sbarbaro, James E...... 2278 Sabanero, Myrna ...... 440 Samelson, Lawrence E...... 553, 556 Scaffi di, Paola ...... 37 Sabass, Benedikt ...... 1633 Sammak, Paul J...... 202 Scarabotto-Neto, Normando ...... 326 Sabo, Pete ...... 2410 Sammons, Morgan ...... 1672 Scarcelli, Jack J...... 133 Sabouri-Ghomi, Mohsen ...... 2379 San Martin, Rody ...... 521 Scarselli, Marco ...... 284 Sachidanandam, Ravi ...... 2440 San Pietro, Enrica ...... 2117 Schachner, Melitta ...... 1273 Sachs, NadineSachs ...... 2345 SanAgustin, Jovenal ...... 451, 453 Schaefer, Andrew W...... 2298 Sackett, Dan L...... 1089 Sánchez Alvarado, Alejandro ...... 10 Schafer, Dorothy A...... 1014 Sacks, David B...... 426 Sanchez-Rivera, Francisco J...... 1541 Schafer, Jenny C...... 2100 Sackton, Katharine L...... 190 Sandberg, Rickard T. H...... 2439 Schafer, Xenia ...... 2447 Sadikot, Takrima ...... 725 Sandblad, Linda ...... 19, 745 Schaff, James C...... 796, 1753, 1943 Sadzynski, A...... 1850 Sanders, Carsten ...... 99 Schaller, Mike ...... 1773 Saeed, Ali M...... 1553 Sanderson, Michael J...... 452 Schaniel, Christoph ...... 206 Saeed, Ramazan ...... 767 Sandiford, Simone ...... 1565 Schatten, Gerald ...... 563, 1756 Saengsawang, Witchuda ...... 2338 Sandoval Bernal, Gerardo ...... 530 Schaub, Beat E...... 1993 Saffi tz, Jeffrey ...... 907 Sane, Komal M...... 772 Schaus, Thomas E...... 1702 Sage, Harvey J...... 2332 Sanford, Gary ...... 1831 Schek, Henry T...... 19, 387, 1500 Saha, Sougata ...... 469, 862, 2378 Sanford, Samantha L...... 216 Schell, Michael J...... 2284 Sahasrabudhe, Ruta M...... 659 Sang-Hyun, Park ...... 610 Schevzov, Galina ...... 441, 936, 1676, 2288 Sahasrabudhe, Sudhir ...... 1629 Sanger, Jean M...... 724 Schiaffi no, Maria V...... 1981 Sahi, Chandan ...... 53 Sanger, Joseph W...... 724 Schiavo, Giampietro ...... 2128 Sai, Xiaorei ...... 2134 Sangrar, Waheed ...... 1474 Schieber, Michael ...... 56 Said, Heather ...... 948 Sanny, Justina S. P...... 1609 Schiffenbauer, Yael S...... 1201, 1202 Said, Sami I...... 1835 Sano, Toshio ...... 2393 Schiller, Martin R...... 249 Saino, Tomoyuki ...... 79, 741, 742 Santoro, Michele ...... 825 Schjerling, Peter ...... 209 Saint-Michel, Edouard ...... 50 Santos, Marinilce F...... 513, 2266 Schlager, Max A...... 708 Saito, Hidekazu ...... 568, 579, 1826, 2038 Santos, Ana ...... 87 Schlatter, Monika ...... 2293 Saito, Masaki ...... 283 Santy, Lorraine C...... 400 Schleicher, Michael ...... 418, 2245, 2377 Saito, Yuhi ...... 181, 182 Sanzen, Noriko ...... 1585 Schmid, Sandra ...... 1096 Sakabe, Masahide ...... 2019 Saotome, Ichiko ...... 930 Schmidt, Benjamin T...... 231, 93 Sakaguchi, Masakiyo ...... 1366, 2197 Sapir, Tamar ...... 44 Schmidt, Christoph F...... 384, 385, 756, 834, 1636 Sakaguchi, Takehisa ...... 2172 Saporita, Jennifer A...... 268 Schmidt, John A...... 2008 Sakaguchi, Yoshihiko ...... 1366 Sapoznik, Sivan ...... 44 Schmidt, Rebecca L...... 1338 Sakai, Kimie ...... 1197 Saprunova, Valeria ...... 1289 Schmitz, Ian ...... 1578 Sakai, Keiko ...... 2172 Saraiva, E. M...... 1323 Schmitz, Michael ...... 658 Sakai, Takao ...... 2172 Sargin, Emre ...... 1463 Schmoranzer, Jan ...... 499, 1450 Sakakibara, Hitoshi ...... 978, 979 Sargin, Mehmet E...... 1449 Schmutz, Cornelia ...... 1048 Sakakibara, Nozomi ...... 1540 Sarin, Apurva ...... 802 Schnaper, H. William ...... 1827 Sakamoto, Kazuma ...... 593 Sarkar, Souvik ...... 1677 Schneider, Andre ...... 1624 Sakamoto, Takeshi ...... 968 Sarkeshik, Ali ...... 1668 Schneider, Ian ...... 814, 2272 Sakata, Haruhito ...... 1362 Sarmah, Swapnalee ...... 2111 Schneider, Pascal ...... 1810 Sakata, Hirokazu ...... 2019 Sarri, Elisabet ...... 2104 Schneijdenberg, Chris T. W. M...... 1935 Sakata, Kensei ...... 397 Sasai, Masao ...... 270 Schnittker, Robert ...... 493 Sakiyama, Hiroki ...... 270 Sasaki, Hiroyuki ...... 1337 Schnur, Joel M...... 1199 Sakowicz, Roman ...... 1025 Sasaki, Keiko ...... 1184 Schöbel, Susanne ...... 1104 Sakurai, Atsuko ...... 1902 Sasaki, Yukio ...... 962 Schöck, Frieder ...... 60, 245 Sakurai, Takashi ...... 712 Sata, Tetsutaro ...... 166 Schoenbach, Karl H...... 684 Salam, Ambar A...... 2329 Satir, Birgit H...... 1122 Schoff, Chris ...... 26 Salas, Pedro J...... 2066, 2069 Satir, Peter ...... 446, 450 Schonteich, Eric ...... 2253 Salazar, Gloria ...... 1982 Satish, Basanthi ...... 648 Schorey, Jeff ...... 1874 Sale, Winfi eld S...... 975, 976 Satkamp, Laura A...... 2004 Schrader, John W...... 709 Saleem, R. A...... 1625 Sato, Aya ...... 1641 Schreiter, Jennifer H...... 2242, 2244 Saleh, Tamjeed ...... 2427 Sato, Akitsugu ...... 1890 Schröder, Andreas ...... 1703 Salgado, Luis Miguel ...... 440 Sato, Ken ...... 2124 Schroeder, Barbara ...... 1097 Sali, Andrej ...... 1626 Sato, Miyuki ...... 2124 Schroeder, Cheryl A...... 2082 Salic, Adrian ...... 1539 Sato, Showbu ...... 860 Schroeder, Valerie ...... 1874 Salikhova, Anna ...... 2269 Sato, Takashi ...... 1379, 2124 Schroer, Trina A...... 1668, 1669 Salimian, Sasan ...... 140 Sato, Takeya ...... 776, 1291 Schubert, Vanessa ...... 1272 Salin, Paul ...... 786 Satoh, Ayano ...... 2120 Schugar, Rebecca C...... 231, 1174 Salinas, Sara ...... 2128 Satoh, Shigeru ...... 181, 182 Schulte, Marvin K...... 2369 249 AUTHOR INDEX The American Society for Cell Biology 47th Annual Meeting December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

Schuster, Christopher C...... 1967 Serino, Ryota ...... 1811 Shen, Wen-Jun ...... 278, 1221 Schvarzstein, Mara ...... 1513 Serio, Alisa W...... 31 Shen, Xin-Ming ...... 781 Schwartz, Joel W...... 1939, 1940 Serio, Tricia R...... 55 Shen, Yongquan ...... 900 Schwartz, Martin ...... 323, 815 Serpinskaya, Anna S...... 699 Sheng, Zu-Hang ...... 1275 Schwarz, Ulrich ...... 1633 Seth Chhabra, Ekta ...... 1037 Shenoy, Vivek ...... 2373 Schwarz-Herion, Kyrill ...... 842 Setou, Mitsutoshi ...... 860 Shepard, Blythe D...... 506 Schwarzbauer, Jean E...... 206 Settleman, Jeffrey ...... 1567 Sheppard, Dean ...... 1806 Schweitzer, Jill K...... 559 Seveau, Stephanie ...... 33 Sher, Alan ...... 525 Schwille, Petra ...... 1515 Sever, Sanja ...... 1095 Sheremet, Yarina A...... 1459, 1462 Sciorra, Leonard J...... 246 Severin, Fedor F...... 1289 Sheridan, Judson ...... 913 Scott, Brenton L...... 264, 1336 Seye, Cheikh ...... 409 Sheridan, Steven D...... 213, 214, 1188 Scott, Cameron C...... 1974 Sha, Jian ...... 549 Sherman, Diane L...... 1311 Scott, John ...... 1822 Sha, Zhe ...... 705 Sherman, Stephanie ...... 1372 Scott, Michelle ...... 1474 Shaban, Mona ...... 981 Sherrard, Kristin M...... 1615 Scott, Ray ...... 2212 Shackel, Nicholas A...... 1084 Sherwin, Trevor ...... 248, 908 Scott, Robert J...... 1965 Shaffer, Christopher D...... 1743 Shestakova, Anna ...... 1998, 2000 Seabra, Miguel C...... 1079 Shaffer, Jonathan M...... 2173 Sheu, Jessica ...... 1287 Sealfon, Stuart C...... 558 Shaffer, Meredith H...... 930 Shi, J...... 1606 Searby, Charles C...... 463 Shafi khani, Sasha ...... 27 Shi, Lei ...... 1986 Sebban, Shulamit ...... 597 Shah, Alok S...... 463 Shi, Mi ...... 1593 Sebe, Attila ...... 1758 Shah, Miti ...... 1574 Shi, Yun-Bo ...... 1056 Sebring, Sarah A...... 382 Shah, Mrinal Y...... 1603 Shi, Yang ...... 2438 Sedat, John W...... 2423 Shah, Samar ...... 1699 Shi-wen, Xu ...... 318 Sedlic, Filip ...... 1296 Shah, Sanjiv ...... 187 Shibata, Etsuko ...... 1242 Sedlmayr, Peter ...... 1907 Shah, Sameer B...... 1938 Shibata, Tatsuya ...... 1811 Seemann, Joachim ...... 1507 Shaikh, Saame R...... 2429 Shibayama, Mineko ...... 530 Segal, Daniel ...... 86 Shailesh, Shenoy M...... 334 Shidara, Yujiro ...... 711 Segal, Rosalind A...... 1658 Shakespeare, Teresa I...... 911 Shie, Jue-Lon ...... 1818 Segall, Anca M...... 1536 Shamu, C...... 1606 Shields, Dennis ...... 1564, 2006 Segall, Jeffrey ...... 1472 Shanahan, Catherine M...... 1651, 1950 Shields, Vonnie D. C...... 779, 1746 Segev, Nava ...... 2080 Shanina, Nina A...... 1664 Shifrin, Yulia ...... 1759 Segura, Miriam ...... 499 Shankardas, Jwalitha ...... 80 Shigemitsu, Takanari ...... 182 Segura-Totten, Miriam ...... 1249 Shao, Shiying ...... 1175 Shigunov, Patrícia ...... 1182 Sehgal, Pravin B...... 2088, 2089 Shapiro, Lucy ...... 848, 1040, 1657 Shih, Hsiu-Ming ...... 1861 Sehgal, Siddharth ...... 1998 Shapiro, Marietta E...... 771 Shih, Wenting ...... 905 Seiki, Motoharu ...... 579 Shapovalova, Zoya ...... 2112 Shih, Yu-Ling ...... 2381 Seipel, Susan A...... 2050 Sharek, Lisa ...... 2171 Shikanai, Yuuki ...... 79 Seipelt, Rebecca L...... 889 Sharma, Alok ...... 160 Shilton, Brian H...... 2156 Seiryo, Sugiura ...... 509 Sharma, Aarti ...... 2338 Shim, Eun Yeong ...... 610 Seiser, Robert M...... 1752 Sharma, Ajay ...... 523 Shim, Insop ...... 1186, 1187 Seki, Keiko ...... 1337 Sharma, Chandan ...... 882 Shima, Ai ...... 1074 Sekiguchi, Kiyotoshi ...... 1585 Sharma, Cristain R...... 1356 Shimabukuro, Katsuya ...... 2257 Sellers, James R. ...960, 961, 965, 966, 968, 969, 2304 Sharma, Jay ...... 1356 Shimada, Akiko ...... 775 Sellito, Caterina ...... 911 Sharma, Mahak ...... 1105 Shimada, Takeaki ...... 181 Selmi, Carlo ...... 2353 Sharma, Manu ...... 1264 Shimada, Tadayuki ...... 2286 Selvaraj, Vimal ...... 2059, 2060, 2433 Sharma, Michael R...... 1356 Shimi, Takeshi ...... 1946, 36 Selvin, Paul R...... 2382 Sharma, Namit ...... 1775 Shimonovich, Shachar ...... 113 Semenova, Irina ...... 24, 694 Sharma, Neeraj ...... 2396 Shin, Bongjin ...... 683 Semmrich, Christine ...... 2376 Sharma, Pushpa ...... 1281 Shin, Dong-Mi ...... 2305 Sen, Shamik ...... 1389 Sharma, Shaleekha K...... 1356 Shin, Eulsoon ...... 1562, 1860, 1863 Senegaglia, Alexandra ...... 1182 Sharp, David J...... 495, 641, 832, 1440, 1446, 2216 Shin, Hyo-Jung ...... 1561 Senga, Takeshi ...... 642 Sharp, Phillip A...... 2437, 2439 Shin, Hyo S...... 1060 Sengupta, Debrup ...... 2002 Sharpe, Richard ...... 2023 Shin, Jong-Chul ...... 1900 Sengupta, Kheya ...... 1420 Shastry, Barkur S...... 1828 Shin, Kyung-Seon ...... 1067 Sengupta, Kaushik ...... 841 Shaw, Andrew ...... 1505 Shin, Mee Seon ...... 1829 Sengupta, Prabuddha ...... 2059, 2430 Shaw, Sidney L...... 1447 Shin, Sanghee ...... 1562, 1860, 1863 Sengupta, Suparna ...... 759 Shea, Lonnie ...... 883 Shin, Won-Sik ...... 1856 Senning, Eric N...... 703, 713 Shea, Thomas B...... 2341, 2349 Shinagawa, Kunihiro ...... 1341 Senoo, Haruki ...... 1218 Shears, Steve ...... 1548 Shinde, Arti V...... 1576 Sens, Pierre ...... 831, 1679 Sheets, Erin D...... 1137, 2068, 2436 Shinichiro, Hanada ...... 2347 Seo, Jung Ho ...... 1167 Sheetz, Michael P...... 813, 1592 Shinji, Hitomi ...... 1337 Seo, Kang-Sik ...... 673, 674, 1560, 2290 Sheff, David R...... 2098 Shinn-Thomas, Jessica H...... 249 Seok, Jeong Ho ...... 1562, 1860, 1863, 1865 Sheffi eld, Mark ...... 812 Shinohara, Akira ...... 1642 Seong, Rho H...... 1059, 1240 Sheffi eld, Val C...... 463 Shinohara, Miki ...... 1642 Sepich, Diane S...... 1050 Shemer, Gidi ...... 671, 901 Shinsaku, Maruta ...... 394, 396 Sepp-Lorenzino, Laura ...... 1190 Shen, Che-Hung ...... 1529, 1567 Shintani, Yasushi ...... 352 Sept, David ...... 933 Shen, Kang ...... 47 Shioda, Setsuko ...... 102 Serafi midis, Yanni ...... 415 Shen, Li ...... 104 Shioda, Toshi ...... 2013 Serasinghe, Madhavika N...... 1290 Shen, Meng-Ru ...... 592, 1146, 1869 Shiozuka, Masataka ...... 1401 Serbus, Laura R...... 34 Shen, Rong-Fong ...... 2309 Shirwany, Najeeb ...... 1377 Serebriiskii, Ilya ...... 1471, 1812 Shen, Shu ...... 254 Shmulevich, I...... 1625 250 The American Society for Cell Biology 47th Annual Meeting AUTHOR INDEX December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

Shokat, Kevan M...... 11, 1600, 1632 Siskind, Leah J...... 805 Sobczak, Magdalena ...... 1697, 938 Show, Matthew A...... 856 Sisson, John S...... 1064 Sobel, André ...... 2303 Shows, Eric B...... 844 Sitaram, Anand ...... 1981 Soberanes, S...... 1764 Shpak, Max ...... 1989 Siu, Chi-Hung ...... 2144, 2145 Soderberg, Ola ...... 95 Shtridelman, Yuri ...... 704 Sivagurunathan, Senthilkumar ...... 1667 Sodhi, Chhindra ...... 90 Shtutman, Michael ...... 1533 Sivaramakrishnan, Sivaraj ...... 1637 Soga, Ikko ...... 1729 Shumaker, Dale K...... 1255, 1953 Sivendran, Renuka ...... 885 Sognier, Marguerite A...... 357, 1172, 1739 Shuman, Henry ...... 1688 Siwetz, Monika ...... 1219 Sohn, Dong H...... 1240 Shuster, Charles B...... 1514 Sixt, Michael ...... 96, 483, 1467 Sohn, Joon Hyung ...... 1352, 2184 Shutes, Adam ...... 43 Skach, William R...... 52, 1156 Soignier, Yvette ...... 577 Shuto, Tsuyoshi ...... 158, 574, 1379, 1530 Skalnik, David G...... 1062 Sokac, Anna Marie ...... 2058 Shvartsman, Dmitry E...... 2139 Skalski, Michael ...... 62, 1775 Sokolov, Sviatoslav ...... 1289 Shvartsman, Stanislav Y...... 221, 558 Skau, Colleen T...... 2389 Solaiyappan, Meiyappan ...... 1791 Sibarita, Jean-Baptiste ...... 1547 Skoch, Jesse ...... 1095 Soltaninassab, Syrus ...... 1413A Sible, Jill ...... 2148 Skotheim Hillis, Kris ...... 755 Sole, Marieta ...... 1741 Sibley, L. D...... 922 Skowronek, Krzysztof ...... 1718 Solmonson, Ashley D...... 977 Siddiqui, Mohammad R...... 949 Skube, Susan B...... 757 Solnica-Krezel, Lilianna ...... 861, 1050, 2111 Sider, Jenny R...... 663 Sladewski, Thomas E...... 666 Solomon, Jonathan ...... 1065 Sidoni, Angelo ...... 2196 Slater, Quinn ...... 957 Solon, Jerome ...... 750 Siebert, Aubrey ...... 779 Slattum, Gloria ...... 1613 Solovei, Irina ...... 36 Siemers, Kathy ...... 438 Slaughter, Brian ...... 1939 Solovyeva, Anfi sa ...... 1577 Sierra, Johanna C...... 549 Slepak, Vladlen ...... 1565 Solowska, Joanna M...... 2294, 2295 Siesser, Priscila M. F...... 403 Slepchenko, Boris M...... 422, 701, 796, 1753 Somers, David E...... 1595 Sievert, Martin ...... 321 Slijper, Monique ...... 550 Somlyo, Avril ...... 2234 Sihlbom, Carina ...... 39 Slisz, Michael ...... 606 Sommers, Connie L...... 556 Sihvo, Maarit ...... 1015 Sloboda, Roger D...... 974 Sonawane, Shobha ...... 951 Silfl ow, Carolyn D...... 972 Slupe, Andrew M...... 1278 Sonegawa, Hiroyuki ...... 1366, 2197 Silk, Alain D...... 1604 Slupphaug, Geir ...... 1489 Song, Hasuk ...... 171, 179 Sillibourne, James E...... 1429 Small, Aaron J...... 532 Song, Ji-Yeo ...... 2198 Silva, Mariana ...... 2209 Šmejkalová, Barbora ...... 2337 Song, Jia L...... 2055 Silva-Neto, Mario A. C...... 1322 Smith, Andrew L...... 367, 1926 Song, Ki-Hyun ...... 156 Silveira e Souza, Adriana M. M...... 301 Smith, Danielle ...... 1145 Song, Kyoung-Sub ...... 673, 674, 1560, 2155, 2290 Silver, Debra L...... 2031 Smith, DeAnna ...... 904 Song, Moon-yong ...... 2044 Silver, Pamela A...... 8 Smith, Gilbert H...... 237, 578 Song, Mi hye ...... 620 Silvis, Mark ...... 2125 Smith, Harold ...... 2045 Song, Qinhui ...... 1818 Simakova, Olga ...... 1884 Smith, Jason ...... 2142 Song, Sunmi ...... 1084 Simanis, Viesturs ...... 2246 Smith, James ...... 939 Song, Woo Keun ...... 1781 Simen, Birgitte B...... 2201 Smith, J. J...... 1625 Song, Young Ho ...... 200 Simerly, Calvin ...... 1756 Smith, Lee ...... 2023 Sonnenberg, Arnoud ...... 1376 Simionescu, Adriana ...... 739 Smith, Mark A...... 1715 Sontag, Christopher A...... 2332 Simmons, David ...... 40 Smith, Norah L...... 1844 Sontam, Dharani ...... 1297 Simon, Dan ...... 1945 Smith, Pliny A...... 1072 Sook Hee, Kim ...... 1846 Simon, Glenn C...... 2253 Smith, Peter G...... 1881 Sorci, Guglielmo ...... 2196 Simon, Martha N...... 1199 Smith, Peter L. P...... 39 Sorensen, Erika B...... 1100 Simon, Sanford M...... 263, 542, 669, 670, 2095 Smith, Peter R...... 1002, 1003 Sorger, Peter K...... 1501, 2235 Simone, Robert ...... 2319 Smith, Roger ...... 1332 Sorimachi, Hiroyuki ...... 721 Simons, Kai ...... 5, 1383 Smith, Ronald D...... 1827 Sorisky, Alexander ...... 602 Simons, Matias ...... 191 Smith, Richard D...... 1999, 2000 Sorrentino, Vincenzo ...... 2065 Simpson, Jamie ...... 2161 Smith, Sarah E...... 1939 Sosa, Hernando ...... 832 Simpson, Jeremy C...... 1991 Smith, Susan M...... 1557 Sosa, Zulema ...... 769 Sin, Wun C...... 2271 Smith, Tekla ...... 916 Sotelo, Tamara ...... 521 Sinclair, Paul B...... 2408 Smith, Tara C...... 1007 Sotirakis, Emmanuel ...... 1262 Sindelar, Charles V...... 391 Smith, Ursula M...... 460 Soto, Edwin ...... 895 Sine, Steven M...... 781 Smith, William C...... 374, 763 Sotos, Josh ...... 1413A Singer, Matthew A...... 1189 Smith, William J...... 826, 1091 Sougrat, Rachid ...... 1315 Singer, Robert H...... 22, 128, 334, 967, 1263 Smith, Yoland ...... 1565 Soung, Nak-Kyun ...... 15 Singh, Alka ...... 1319 Smithback, Philip A...... 835 Sousa, Ana M...... 748 Singh, Jitendra ...... 1913 Smithgall, Thomas E...... 1305, 2173 Souto-Adeva, Gema ...... 175 Singh, Komudi ...... 677 Smutny, Michael ...... 2306 Souto-Padron, T. C...... 1323 Singh, Mahendra K...... 1812 Smyth, Jeremy T...... 1131 Soutoglou, Evi ...... 1652 Singh, Purva ...... 1806 Snapp, Erik L...... 169, 177, 180, 1155, 1484, 2434 Soza, Andrea ...... 2126 Singh, Ramandeep ...... 296 Snee, Mark J...... 220 Spallek, Thomas ...... 29 Singh, Rahkumar S...... 162 Snell, William J...... 187, 449 Spandau, Dan ...... 586 Singh, Vinay ...... 1481 Sniadecki, Nathan J...... 313 Spang, Anne ...... 1048, 1520 Singh, Vijay P...... 1027 Snooks, Michelle J...... 538 Spano, Anthony ...... 1199, 2331 Sinha, Debasish ...... 2364 Snow, Andrew ...... 2305 Spatz, Joachim P...... 1801 Sinha, Manisha ...... 1429 Snyder, Joshua ...... 2053 Spector, Alexander A...... 1010 Sinka, Rita ...... 2205 Snyder, Michael ...... 967 Speicher, David ...... 1000, 316 Sipkema, Detmer ...... 1912 So, King Yip Ken Y. K...... 770 Spencer, Adam ...... 1876 Sirito, Mario ...... 566 Soares, Raquel ...... 1347 Spencer, Chris ...... 2037 Sisan, Dan ...... 1640 Soares e Silva, Marina ...... 836 Sperling, Anne ...... 930 251 AUTHOR INDEX The American Society for Cell Biology 47th Annual Meeting December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

Sperry, Ann O...... 2039 Stewart, Colin L...... 560, 1254 Suico, Mary Ann ...... 158, 574, 1379, 1530 Sperry, Rebecca ...... 335, 337 Stewart, Murray ...... 2257, 2258, 2259 Sukegawa, Jun ...... 283, 776, 1291 Spiliotis, Elias T...... 947 Stewart, Mara ...... 587 Sullivan, Jessica L...... 2168 Spinel, Clara M...... 1164, 1165, 1177, 1178 Stickney, John T...... 2067 Sullivan, Nora L...... 121, 852, 853 Spira, Felix ...... 2063 Stirling, Lee ...... 1133 Sullivan, William T...... 34 Spiridonov, Ilia S...... 1645, 2213 Stith, Bradley J...... 2053 Sumanasinghe, Ruwan ...... 917, 1208 Splinter, Daniël ...... 717 Stochaj, Ursula ...... 502 Sumida, Yasuhiro ...... 1585 Splinter, Patrick L...... 455, 531, 532 Stock, Fabrice ...... 1200 Summers, Susan ...... 353 Spriet, Corentin ...... 152 Stoica, Radu E...... 1169 Sun, Changxia ...... 843 Squirrell, Jayne M...... 1520, 167, 2249 Stojanovic, Aleksandra ...... 1804 Sun, Hongliu ...... 1058 Sreepathi, Shruti ...... 1776 Stokasimov, Ema ...... 2371 Sun, Jianjun ...... 2147 Srikanth, Sonal ...... 553 Stolfa, Gino ...... 1326 Sun, Lu ...... 2057 Srinivasan, Dayalan G...... 639 Stoll, Dieter ...... 1191 Sun, Ning ...... 2340 Sriram, Vishwanath ...... 802 Stone, Elisa M...... 1589 Sun, Shan ...... 1871 Sriskanthadevan, Shrivani ...... 2143, 2144, 2145 Stone, John W...... 879 Sun, Wei ...... 1193 Srivastava, Deepak ...... 964 Stone, Michelle C...... 2300 Sun, Yi ...... 1998 Srivastava, Jyoti ...... 1779 Storkebaum, Erik ...... 786 Sun, Zhaoxia ...... 1602 Srivastava, Madhulika ...... 523 Storrie, Brian ...... 1998 Sund, Derrick T...... 1280 St. Croix, Claudette M...... 1904 Storz, Peter ...... 902 Sundaram, Shanthy ...... 1346 St. Johnston, Daniel ...... 1425 Stosik, Magdalene ...... 1198 Sundaresan, Tharun ...... 155 St-Denis, Nicole A...... 2149 Stossel, Thomas P...... 935 Sundberg, Eric J...... 736 Stachowiak, Matthew ...... 439, 473 Stöter, Martin ...... 1984 Sundstrom, Jeffrey M...... 100 Stack, M. Sharon ...... 883 Stottrup, Benjamin L...... 1797 Sung, Boo Hee ...... 1334, 1360 Stadnichuk, Vladimir I...... 893 Strack, Stefan ...... 774, 1278, 1279 Sung, Bong Hwan ...... 1781 Stagg, Scott ...... 1621 Strande, Louise F...... 2203 Sung, Ching-Hwa ...... 2132 Stahl, Mark ...... 1926 Strasberg Rieber, Mary ...... 687 Sung, Ki Sa ...... 1528 Stahl, Philip D...... 2093 Strickland, Sidney ...... 379 Sung, Myong-Hee ...... 108 Staiger, Christopher J...... 1017 Stringer, James ...... 114 Sung, Mia ...... 2410 Stainier, Didier Y. R...... 88 Strnad, Pavel ...... 41, 2347, 2348, 2353, 2354, 2365 Sung, Patrick ...... 1502 Stajich, Jason E...... 638 Stroehle, Fabian ...... 1295 Sung, Woo Sang ...... 792 Stamatoyannopoulos, John ...... 2410 Stroh, Thomas ...... 1996 Sung Sik, Han, ...... 543 Stamer, W. D...... 1384 Stroka, Kimberly ...... 1468 Sunkel, Claudio E...... 2224 Stansell, Elizabeth ...... 534 Strong, Michael J...... 123 Suominen, Tiina ...... 566, 567 Stanton, Bruce ...... 1328 Stroope, Angela J...... 456, 457, 1393 Superneau, Allison ...... 1168 Stanton, Leslie ...... 840 Strugnell, Scott S...... 1473 Suprenant, Kathy ...... 765 Starr, Daniel A...... 714, 1430 Stuart, Heather C...... 126 Surmak, Andrew ...... 378 Stasevich, Tim ...... 152 Stuart, Melissa K...... 1138 Surrey, Thomas ...... 19, 383, 387, 1453, 2241 Stathopoulos, Angelike ...... 224 Stuckey, Jeanne ...... 1733 Suryawanshi, Swati ...... 2396 Stear, Jeffrey ...... 751 Stukenberg, P. Todd .....1448, 1499, 1643, 2219, 2225, Susman, Micheal W...... 2399 Stefan, Christopher J...... 830, 1112 2230, 2232, 2234 Susuki, Seiko ...... 1379 Stefanovsky, Victor Y...... 816 Sturany, Sabine ...... 1191 Suter, Daniel M...... 808, 2291 Stehn, Justine ...... 442 Styers, Melanie L...... 2085, 2103 Sutoh, Kazuo ...... 491 Steigemann, Patrick ...... 658 Su, Bessie ...... 28 Suzuki, Atsushi ...... 94 Steimle, Paul A...... 2320, 2321, 2322 Su, Dong-Ming ...... 1061 Suzuki, Ikuro ...... 899 Stein, Gary S...... 1220 Su, Li-Ting ...... 2275 Suzuki, Junko ...... 1711 Stein, Janet L...... 1220 Su, Tin Tin ...... 587 Suzuki, Nobuharu ...... 874 Steinberg, Benjamin E...... 1976 Su, Wu-Chou ...... 137 Suzuki, Osamu ...... 2048 Steinem, Claudia ...... 831 Su, Xue feng ...... 1002, 1003 Suzuki, Toshiharu ...... 1883 Steiner, Stephanie ...... 186 Su, Xiong ...... 2093 Suzuki, Yuki ...... 119 Steinmetz, Andre A...... 1710 Suarez, Giovanni ...... 549 Svard, Staffan ...... 1631 Steller, Hermann ...... 86 Subramani, Suresh ...... 184 Svenson, Kristine ...... 1926 Stelzer, Ernst H. K...... 1179 Suburo, Angela M ...... 287 Sverdlov, Maria ...... 260 Stepanyan, Ruben ...... 958 Suckow, Mark ...... 1874 Svergun, Dimitri ...... 486, 488 Stephan, Dietrich A...... 315 Sud’ina, Galina F...... 893 Svitkina, Tatyana ...... 24, 469, 2378 Stephan, Jean P...... 1358 Sudhof, Thomas ...... 1264 Svoboda, Kurt ...... 791 Stephanopoulos, Gregory ...... 505 Sudol, Marius ...... 2179 Swanson, Andrew M...... 962 Stephens, Andrew D...... 956 Sue Menko, A...... 370 Swanson, Joel A...... 303 Stephens, Nina ...... 1805 Suekawa, Kimberly ...... 731 Swanson, James R...... 684 Stephens, Stephen ...... 959 Suga, Yasushi ...... 89 Swanson, Selene ...... 2412 Stepp, Mary Ann ...... 872, 884, 1806, 2276 Sugahara, Takuya ...... 574 Swanwick, Catherine Croft ...... 771 Stern, David L...... 639 Suganuma, Tamaki ...... 2412 Swayne, Leigh Anne ...... 1130 Sternberg, Paul W...... 1077 Sugaya, Kimihiko ...... 149 Swedlow, Jan J...... 1496 Sternlicht, Mark D...... 1582 Suggs, Jennifer A...... 2316 Swedlow, Jason R...... 1496, 2210 Stetler-Stevenson, William G...... 885 Sugimoto, Yukihiko ...... 1883 Sweeney, H. Lee ...... 312, 1389, 1696 Steven, Alasdair C...... 1108 Sugimura, Yoshiki ...... 375 Swiatek, Marcin ...... 1728 Stevens, Julia ...... 1048 Sugiura, Tadao ...... 2286 Swoboda, Peter ...... 447, 454, 465 Stevens, Leslie M...... 1750 Sugiya, Hiroshi ...... 81 Sykes, Cécile ...... 2260 Stevens, Naomi R...... 1425 Suh, Pann-Ghill ...... 1549 Sykulev, Yuri ...... 892 Stevens, Nathaniel S...... 382 Suh, Sung-Suk ...... 1595 Sylvester, Kristen ...... 1386 Stevens, Traci L...... 405 Suh-Kim, Haeyoung ...... 247 Sytnyk, Vladimir ...... 1273 Stevenson, Tesheka O...... 740 Sui, Xiu F...... 2273 Szabo, Eva ...... 229 252 The American Society for Cell Biology 47th Annual Meeting AUTHOR INDEX December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

Szabó, Gábor ...... 2073 Tanaka, Keisuke ...... 166 Thomas, Miranda ...... 2131, 2170 Szabó, Zoltán ...... 2073 Tanaka, Kunisuke ...... 181 Thomas, Nancy ...... 596 Szabova, Ludmila ...... 378 Tanaka, Yosuke ...... 1726 Thomas, Nisha E...... 759 Szczepanowska, Joanna ...... 515 Tanaka, Yoshiya ...... 1811 Thomas, William ...... 1480 Szewczyk, Edyta ...... 627 Tanasa, Bogdan ...... 1621 Thomasset, Nicole G...... 786 Sztul, Elizabeth E...... 2085, 2103 Tanenbaum, Marvin ...... 717 Thompson, Danielle ...... 1361 Szuchet, Sara ...... 789 Tang, Amy H...... 1338 Thompson, James ...... 1394 Szymanski, Kimberly M...... 512 Tang, Fusheng ...... 1153 Thompson, Michael W...... 889 Tang, Hsin-Yao ...... 1000 Thompson, Sarah L...... 1648 T Tang, Jay X...... 1466, 1840 Thornton, Laura ...... 607, 1766 Tabb, David ...... 2012 Tang, Vivian ...... 838 Thorpe, Lauren M...... 189 Tachezy, Jan ...... 1624 Tang, Yi ...... 1451 Tian, Aiguo ...... 1049 Tadokoro, Satoshi ...... 270 Tang, Yitai ...... 185 Tian, Song ...... 104 Tadvalkar, Gauri ...... 872, 884, 2276 Tanguay, Robert ...... 91 Tian, Ye ...... 1818 Tago, Kenji ...... 397 Tanida, Isei ...... 89 Tietz, Pamela S...... 455, 1393 Tague, Sarah E...... 1881 Tanoue, Takuji ...... 66 Tifft, Kathryn E...... 1250 Taheri-Talesh, Naimeh ...... 1684 Tao, Guo Z...... 2348, 2352, 2353 Tikhmyanova, Nadezdha ...... 188 Tai, Carolyn ...... 1489 Tao, Rong-Hua ...... 2195 Tikhonenko, Irina ...... 1729, 2215 Taichi, Hara ...... 253 Tao, Tao ...... 1958 Tilley, Leann ...... 1315 Taing, Lee ...... 1801 Tao, Yuan ...... 2352 Tilton, Ronald ...... 242 Tajsic, Tamara ...... 1651 Tarafder, Abul ...... 1079 Timm, Thomas ...... 44, 1454 Takagi, Yasuharu ...... 965 Tardin, Catherine ...... 1636 Timp, Gregory ...... 851 Takahashi, Hideyuki ...... 181 Tartakoff, Alan M...... 112, 1247, 790, 1958 Timp, Winston ...... 851 Takahashi, Hirohide ...... 1949 Tatchell, Kelly ...... 2140 Tinglu, Guan ...... 1957 Takahashi, Nobunori ...... 1578 Tatewaki, Naoto ...... 1527 Tischer, Christian ...... 747, 1455 Takahashi, Nozomi ...... 508 Tatum, Rodney ...... 867 Tisdale, Ellen J...... 707 Takahashi, Toshikazu ...... 524 Tauhata, Sinji ...... 1490 Titorenko, Vladimir ...... 1065 Takahashi, Yuji ...... 568, 579, 1826, 2038 Taulet, Nicolas ...... 355 Tittermary, Sara E...... 405 Takaine, Masak ...... 2367 Taura, Manabu ...... 158 Titus, Margaret A...... 959 Takakura, Ikuro ...... 73 Taute, Katja ...... 1460 Tiwari, Alisa ...... 1226 Takakuwa, Yuichi ...... 280, 1341 Tavares, Álvaro ...... 2209 Tiziani, Stefano ...... 218 Takama, Keiko ...... 1166, 1580 Taya, Shinichiro ...... 1367 Tkachev, Dmitry ...... 1969 Takamatsu, Tetsuro ...... 1558 Taylor, Edwin W...... 1702 To, Derek C...... 435 Takamori, Kazunori ...... 2027 Taylor, Gavin ...... 1741 Toba, Shiori ...... 978, 979 Takamura, Akito ...... 253 Taylor, Lorne ...... 1052 Tobacman, L.S...... 720 Takano, Kaoru ...... 2048 Taylor, Stephen S...... 1499 Tobias, John ...... 2417 Takano, Takahiro ...... 263 Tchelebi, Teodora ...... 1830 Tobias, Kloepper ...... 1620 Takano, Tatsuya ...... 508 Tegelberg, Saara S...... 1879 Toft, David ...... 1876 Takao, Keizo ...... 1890, 1898 Teisberg, Madeline ...... 175 Toivola, Diana M...... 41, 2352 Takata, Kenji ...... 181 Tello, Judith A...... 773 Tokarev, Andrei ...... 2080 Takeda, Morihiko ...... 1837 Teng, Christina T...... 1239 Tokuda, Harukuni ...... 2175 Takeda, Noriyo ...... 2049 Tentler, Dmitri ...... 1577, 1769 Tokunaga, Masaki ...... 1811 Takeda, Naoki ...... 2124 Tenza, Daniele ...... 831 Tokuo, Hiroshi ...... 954 Takeda, Sen ...... 466 Teodorof, Carmen ...... 1781 Tolic-Norrelykke, Iva ...... 943 Takei, Yosuke ...... 1726 Tepass, Ulrich ...... 333 Toma, Claudio ...... 1380 Takei, Yoshifumi ...... 593 Terada, Naohiro ...... 2040 Tomasevic, Nenad ...... 1025 Takeichi, Masatoshi ...... 66 Terai, Masanori ...... 102 Tominaga, Tatsuya ...... 524 Takemaru, Ken-Ichi ...... 1825 Terasaki, Asako G...... 1711 Tomlins, Scott ...... 141 Takeuchi, Kikuko ...... 102 Terenna, Courtney ...... 1683 Tomoko, Nishimura ...... 2177 Takeuchi, Masao ...... 102 Terrian, David M...... 867 Tona, Alex ...... 1173, 1797, 1941 Takeyasu, Kunio ...... 119, 1944, 1949, 1959 Tesh, Vernon L...... 1327 Tong, Zongtian ...... 1039 Takikawa, Osamu ...... 1907 Tetreault, Marie-Pier ...... 72 Tong, Zhen-Yue ...... 2194 Takizawa, Norio ...... 994, 1007 Teusch, Nicole ...... 1051 Tonks, Nicholas K...... 2273 Takumi, Tori ...... 962 Tewari, Manorama ...... 1389 Tooley, John G...... 2234 Talalay, Paul ...... 42 Thach, Thu-Trang ...... 1461 Toomre, Derek K...... 273, 829, 1111, 2094 Talarico, Lou ...... 1015 Tham, Daniel ...... 329 Topczewski, Jacek ...... 2111 Talati, Ronak ...... 2127 Tham, To Nam ...... 33 Torbidoni, Vanesa ...... 287 Tam, Beatrice ...... 2079 Thankiah, Sudhaharan ...... 1707 Toriyama, Michinori ...... 2286 Tam, Christina C...... 273 Tharun, Inga M...... 1453 Torrealba, Carolina ...... 2126 Tam, Yuen Yi C...... 827 Thatcher, Karen N...... 1241 Torrekens, Sophie ...... 749 Tambe, Dhananjay ...... 2373 Theibert, Anne ...... 45, 1268 Tortosa, Elena ...... 760 Tamura, Isao ...... 690 Theos, Alexander C...... 1981 Toshiaki, Mitsui ...... 396 Tamura, Masahito ...... 1811 Theriot, Julie A...... 848, 1638, 2277 Toshinari, Misaki ...... 742 Tan, Dongyan ...... 832 Thiel, Corinna ...... 1198 Toshkov, Ilya ...... 1599 Tan, Serena ...... 499 Thies, Edda ...... 752 Toso, Alberto ...... 1495 Tanaka, Daisuke ...... 1898 Tholl, Stéphane ...... 1710 Tosso, Perrer N...... 904 Tanaka, Elly M...... 1588 Tholozan, Frederique ...... 1798 Toth, Judit ...... 969 Tanaka, Hideo ...... 1558 Thomas, Clement ...... 1710 Touret, Nicolas ...... 302 Tanaka, Kana ...... 1782 Thomas, David D...... 959 Toutchkine, Alexei ...... 1486 Tanaka, Kazuma ...... 2130 Thomas, Graham H...... 1001, 1678 Tower, Cristy D...... 2103 Tanaka, Keiko ...... 166, 381 Thomas, Keena S...... 2274 Townsend, Brigitte ...... 704 253 AUTHOR INDEX The American Society for Cell Biology 47th Annual Meeting December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

Tra, Yolande ...... 146 Turkel, Nezaket ...... 226 Valentijn, Jack A...... 1117, 1121, 1935 Traktman, Paula ...... 1249 Turner, Christopher E...... 997 Valentijn, Karine M...... 1117, 1121 Tran, Andy ...... 1456 Turner, Natalie ...... 1486 Valentine, Megan S...... 289, 783 Tran, Marie E...... 664, 1635 Turoverova, Lidya ...... 1577, 1769 Valiunas, Virginijus ...... 909 Tran, Phong T...... 18, 1683 Tuszynski, Jack ...... 150, 1457 Valladares, Denisse ...... 521 Tran, Susan L...... 1734 Tutana, Trisha ...... 561 Vallee, Richard B...... 497, 499, 1415, 1661, 1662 Tran, Ton Hoai ...... 1085 Tuvim, Michael ...... 264, 1336 Vallen, Elizabeth A...... 2242, 668 Traub, Linton M...... 1090 Tüzel, Erkan ...... 1639 Vallero, Roxanne O...... 1241 Trautmann, Susanne K...... 1515 Twining, Sally S...... 1796, 288 Vallois, Isabelle ...... 359 Travaglia, Mirko ...... 668 Tyagi, Sanjay ...... 2427 Valtierra, Stephanie ...... 1892, 1894 Travis, Alexander J...... 1203, 2059, 2060, 2433 Tyler, Jessica E...... 2271 van Bergeijk, Jeroen ...... 2282 Traweger, Andreas ...... 1052 Tyler, Rebecca K...... 2221 van Bergen en Henegouwen, Paul ...... 1935 Treece, Erin R...... 1396 Tyska, Matthew J...... 1685, 1686 van de Graaf, Stan F. J...... 1110 Treigyte, Grazina ...... 545 Tyson, John ...... 2148 van der Heide, Peter A...... 2422 Trejo, JoAnn ...... 286, 1102 Tzang, Chi H...... 2025 van der Poel, Chris ...... 1676 Trejo, Theodore R...... 1338 Tzvetanova, Iva D...... 1763, 1767 van der Spoel, Arnoud C ...... 825 Tremblay, Michel ...... 2018 van der Vaart, Babet ...... 20 Trenary, Heather R...... 1396 U van Driel, Linda F...... 1117, 1121, 1935 Trenchi, Alejandra ...... 1081 Uchanska-Ziegler, Barbara ...... 1219 Van Buul, Jaap D...... 906 Treuting, Piper M...... 1825 Uchio-Yamada, Kozue ...... 2048 Van Camp, Mark ...... 749 Tribble, Emily K...... 2256 Uchiyama, Tkakehiko ...... 1341 Van De Water, Livingston ...... 1576, 1806 Trichet, Lea O...... 849, 2260 Uckert, Wolfgang ...... 557 Van der Weele, Corine M...... 131, 1458 Trigatti, Bernardo ...... 1382 Udd, Bjarne ...... 566, 567 Van Houten, Judith L...... 289, 783 Trimble, Kayleigh ...... 643 Ueda, Kazumitsu ...... 1477, 1782 Van Kanegan, Michael J...... 774 Trinkaus-Randall, Vickery ...... 75 Ueda, Tetsuya ...... 157 Van Prooyen, Nancy ...... 2115 Tripathi, Brajendra K...... 2313 Uekawa, Natsuko ...... 1477 Van Raay, Terence J ...... 861, 2142 Tripathi, Mukesh ...... 1320 Uemura, Toshimasa ...... 1181 van Rheenen, Jacco ...... 811, 1472 Troyanovsky, Regina ...... 351 Ueno, Keiko ...... 574 van Roosmalen, Wies ...... 1472 Troyanovsky, Sergey M...... 351 Ueno, Tomonori ...... 166 van Vliet, Vanessa ...... 1703 Trubniakov, Ella ...... 1201, 1202 Ueno, Takashi ...... 89 van Wijnen, Andre J...... 1220 Trucco, Alvar ...... 2117 Ueno, Yoshinobu ...... 305 VanBerkum, Mark F. A...... 195 Truesdell, Peter ...... 1474 Uetrecht, Andrea C...... 1409 VanBuren, Vincent ...... 1211, 1402 Trugnan, Germain ...... 2071, 2119 Ulianich, Luca ...... 173 Vancura, Ales ...... 143, 1237 Truitt, Morgan L...... 546 Ulloa, Viviana ...... 1139 Vancurova, Ivana ...... 1862, 1867 Trummer, Harald ...... 1219 Um, Hong-Duck ...... 681, 1872 Vanden Bosch, An ...... 749 Trussoni, Christy E...... 531, 532 Umehara, Senkei ...... 1207 Vanderhorn, Peter ...... 1205 Tsai, Jin-Wu ...... 1662 Umeki, Nobuhisa ...... 395 Vanderploeg, Eric J...... 2413 Tsai, Kelvin K...... 314, 2417 Umemoto, Tsutomu ...... 1477, 1782 Vandlen, Richard ...... 1358 Tsai, Mu-Shiun ...... 1398 Umen, James G...... 630 Vanhooser, Lisa M...... 98 Tsai, Richard K...... 2311 Umezawa, Akihiro ...... 102 Vanlandingham, Phillip A...... 2182 Tsakraklides, Vasiliki ...... 1541 Umino, Ai ...... 508 VanSlyke, Judy ...... 176 Tsao, Yeou-Ping ...... 153, 582, 2268 Underhill, Tully M...... 126 Varela-Ramirez, Armando ...... 685 Tsapara, Anna ...... 870 Ungar, Daniel ...... 2001 Vargas, Micaela ...... 1231 Tschaplinsky, Timothy ...... 30 Unternaehrer, Juli ...... 1303 Vargas, Pablo ...... 996 Tseng, Boo Shan ...... 2223 Upla, Paula ...... 298 Varghese, Shyni ...... 377 Tseng, Joseph T...... 137 Uppalapati, Maruti ...... 1639, 944 Varia, Sapna ...... 160 Tsou, Jen-Hui ...... 137 Uraguchi-Asaki, Junko ...... 1367 Varma, Dileep ...... 497 Tsuchida, Masako ...... 394 Urbach, Jeffrey S...... 1317, 1461, 1640 Varma, Rajat ...... 892 Tsui, M...... 1606 Urban, Michael ...... 1919, 1920 Varrault, Annie ...... 1130 Tsuji, Akira ...... 2124 Urban, Randall ...... 242 Varughese, Bridget E...... 195 Tsukamoto, Akira ...... 97 Üren, Aykut ...... 236 Vassilopoulos, Stephane ...... 2011 Tsukita, Sachiko ...... 1997 Urich, D...... 1764 Vasudevan, Lavanya ...... 612 Tsukita, Shoichiro ...... 1997 Urushibata, Shunsuke ...... 874 Vaughan, Emily M...... 482 Tsutsumi, Chihiro ...... 1951 Urushihara, Hideko ...... 416 Vaughan, Kevin T...... 1490 Tsutsumi, Makiko ...... 1299 Usas, Arvydas ...... 208 Vaughan, Meredith H...... 339 Tsutsumi, Ryouhei ...... 1080 Ushida, Takashi ...... 97 Vaughan, Patricia ...... 1490 Tsutsumi, Víctor ...... 530 Ushijima, Hironori ...... 571 Vaux, David J...... 159 Tsuzaki, Mari ...... 917, 1208 Usinger, Laurie ...... 1919, 1920 Vavylonis, Dimitrios ...... 479 Tsygankov, Alexander Y...... 399 Usui, Akihiro ...... 1362 Vazquez, Francisca ...... 1531 Tsygankov, Denis ...... 1416 Uteng, Marianne ...... 383, 387 Veatch, Sarah ...... 2430 Tu, Ya-Ting ...... 1858 Utreras, Elias ...... 760 Veeman, Michael T...... 374 Tubbs, Raymond ...... 1209 Veenhoff, Liesbeth M...... 1626 Tucker, David ...... 421, 603 V Veenstra, Timothy D...... 15, 885, 1559 Tucker, Richard P...... 903 Vacanti, Nathaniel ...... 474 Vega, Nora ...... 527 Tucker, Stephanie C...... 707, 1122 Vahala, Kerry J...... 2428 Veiga, Esteban ...... 1335 Tulin, Alexei V...... 1235 Vahedi, Mithaq ...... 117, 1891 Veiseh, Mandana ...... 2418 Tully, Ellen ...... 1864 Vaidyanathan, Hema ...... 1555 Velarde, Nathalie ...... 2046 Tuma, Dean J...... 506 Vail, Mason ...... 219 Velayos-Baeza, Antonio ...... 1380 Tuma, Pamela L...... 506, 2122, 2135 Valdivia, Alejandra ...... 1810 Velez, Marielena ...... 930 Tumbar, Tudorita ...... 111, 238, 2449 Valdivia, Raphael H...... 32 Velho, Michelle ...... 450 Turin, Eric C...... 1817, 1823 Vale, Ronald D...... 492, 494, 657, 1488, 1663, 1665 Vellinga, Ryan ...... 335, 337 254 The American Society for Cell Biology 47th Annual Meeting AUTHOR INDEX December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

Vembar, Shruthi S...... 51 Vorozhko, Valeriya ...... 1448 Wang, Liqin ...... 1670 Vérant, Pascale ...... 1610 Vos, Larissa J...... 2228 Wang, Lingyan ...... 1747 Verastegui, Carole ...... 2128 Voss, Christiane ...... 163 Wang, Michelle D...... 1488, 2383 Verbelen, Jean-Pierre ...... 1459 Voss, Meagen K...... 1419 Wang, Ning ...... 1571 Verbich, David ...... 1991 Vrablik, Tracy L...... 196 Wang, Ping ...... 1330 Verbrugge, Sander ...... 389 Vu, Hai Yen T...... 1862, 1867 Wang, Qiang ...... 1565 Verburg, Jessica ...... 710 Vykhovanets, Elena ...... 1599 Wang, Qian ...... 187, 306 Vercelli, Alessandro ...... 1272 Vyletal, Petr ...... 517 Wang, Rong ...... 2039 Verderame, Michael F...... 2153, 2187, 2188 Wang, Shuibang ...... 1845 Vergarajauregui, Silvia ...... 1975 W Wang, Tong ...... 1694 Verghese, Divya A...... 533 Waddell, Emanuel ...... 1176 Wang, Wen-Ling ...... 1238 Verhalen, Brandy ...... 977 Wade, Deborly ...... 785 Wang, Wei-Chiao ...... 137 Verhey, Kristen J...... 833, 1733 Wadsworth, Patricia ...... 1513, 661 Wang, Won-Jing ...... 1529 Verin, Alexander D...... 1834 Wadsworth, William G...... 197 Wang, Wen Der ...... 2113 Verkleij, Arie J...... 1935 Waghmare, Sanjeev ...... 2449 Wang, Weiping ...... 2225 Verma, Prakhar ...... 258 Wagner, Cynthia R...... 2056 Wang, Xinshuo ...... 1414 Vernier, Kaitlyn M...... 405 Wagner, Erica L...... 225 Wang, Xiwei ...... 2233 Verstraeten, Valerie L. R...... 569, 1254 Wahl, James K...... 887, 898 Wang, Yexun ...... 104 Vetterkind, Susanne ...... 1717 Wainman, Alan ...... 748, 2250 Wang, Yingxiao ...... 1571 Vhrovski, Bernadette ...... 1676 Wakabayashi, Ichiro ...... 1714 Wang, Yang-Kao ...... 233 Via, Zachary W...... 1288 Wakatsuki, Tetsuro ...... 1296, 1716, 2138 Wang, Yang ...... 347 Viana, Matheus P...... 2423 Wake, Hiroaki ...... 1838 Wang, Yu-Li ...... 1196, 1774, 1936 Vicente-Manzanares, Miguel ....475, 1269, 2274, 2317 Wakefi eld, James G...... 748, 767 Wang, Yuexia ...... 1228 Vickerman, Lori A...... 766 Wakita, Hideaki ...... 1838 Wang, Zuo-Zhong ...... 1266 Victoria, Diana M...... 1164, 1165 Walck, Jenna L...... 957 Wang, Zhaohui ...... 14 Vidal, Benedicto C...... 1243, 1575 Walczak, Claire E...... 1447, 1722, 1723 Wang, Zhaoyang ...... 2233 Vidal, Michel ...... 1480 Wald, Flavia A...... 2066, 2069 Wang, Zhixiang ...... 306 Vidal, Rene L...... 773 Waldor, Matthew ...... 854 Wang, Zejun ...... 778 Vidali, Luis ...... 480 Walker, Gary R...... 1396 Wanga, Joyce A...... 555 Vieira, Danielle P...... 1322 Walker, J. D...... 1749 Ward, E. Sally ...... 2424 Vierling, Elizabeth ...... 1911 Walker, Janice L...... 340, 366, 370, 1388 Ward, Tarsha ...... 1505, 2233 Vig, Leena ...... 1525 Walker, Matthew ...... 960, 961 Wardrop, D. J...... 2270 Vig, Monika ...... 552 Walker, Richard A...... 382 Warejcka, Debra J...... 1796 Vigny, Marc ...... 613 Walkley, Steven U...... 1897 Warner, Fiona J...... 1084 Vigoreaux, Jim O...... 719, 723, 1799 Walko, Gernot ...... 2363 Warnke, Silel ...... 619 Vihola, Anna ...... 566, 567 Wall, Joseph S...... 1199 Warren, Derek T...... 1651 Vijayaraj, Preethi ...... 40 Wall, Michelle E...... 917, 1208 Warren, Graham ...... 2120 Vila-Sanjurjo, Anton ...... 1295 Wallace, Karen E...... 1659, 1887 Warren, James W...... 2026 Vilas-Boas, Vanessa F...... 327 Wallace, Matthew S...... 1885 Washburn, Michael P...... 2412 Vilella, Montserrat ...... 2104 Wallace, Valerie A...... 2030 Wasik, Anna ...... 1697 Vilk, Gregory ...... 679 Wallace, William C...... 1885 Wasmeier, Christina ...... 1079 Villar, Joaquin ...... 1470 Wallingford, John B...... 691, 942 Watanabe, Kouichi ...... 73 Villegas, Jessica ...... 823 Wallrabe, Horst ...... 2127 Watanabe, Naoki ...... 2286 Villeneuve, Anne M...... 635 Wallrath, Lori L...... 1248, 2360 Watanabe, Shu-Ichi ...... 2015 Villota, Yesid ...... 528 Walsh, Eileen ...... 1190 Waterman, Clare M...... 372, 438, 814, 1633, Vincent, Peter A...... 365 Walter, Peter ...... 830 1715, 2240, 2272, 2379 Vinnakota, Kalyan C...... 1296, 2138 Walter, Wilhelm ...... 915 Watkins, Amanda ...... 146 Vinopal, Stanislav ...... 2337 Walther, Tobias ...... 830 Watkins, Joseph ...... 1153 Vishnubhotla, Ramana ...... 1871 Wan, Xiaohu ...... 1499, 2229 Watkins, Simon ...... 1904 Viswanathan, Ganesh A...... 558 Wan, Y...... 1625 Watkins-Chow, Dawn ...... 2031, 2200 Viswanathan, Vijay ...... 964 Wanderling, Sherry ...... 2201 Watras, James ...... 1551 Vitorino, Philip ...... 2442 Wang, Aibing ...... 2307 Watson, Nathan P...... 588 Vitriol, Eric A...... 1411 Wang, C.-L. Albert ...... 1029 Watters, James ...... 1190 Vittorio, Gallo ...... 782 Wang, Chih-Chiang ...... 153 Wean, Sarah E...... 923 Vives-Rodriguez, Gloria ...... 891 Wang, Chih-Lueh Albert ...... 1698 Weaver, Anne ...... 83 Vizcarra, C...... 747 Wang, Chia-Mei ...... 1861 Weaver, Alissa M...... 308, 2400 Vlahovich, Nicole ...... 1676 Wang, Chun-Chao ...... 420, 1550 Weaver, Beth A. A...... 1604 Vodjdani, Guilan ...... 2022 Wang, Dongmei ...... 1325 Weaver, Lindsay L...... 1960 Voehringer, David ...... 1205 Wang, Fengsong ...... 1116, 2237 Weaver, Valerie M...... 314, 317, 323, Voekler, Kevin A...... 2137 Wang, Francis W...... 1407 341 , 1591, 1803, 2417 Vogel, Elizabeth M...... 407 Wang, Guixia ...... 1355 Webb, Donna J...... 401, 2400 Vogel, Sven K...... 943 Wang, Guanghui ...... 2309 Webber, Elizabeth A...... 1987 Vogel, Stefanie N...... 344 Wang, Hui ...... 479 Weber, Jason ...... 1730 Vogl, Adalbert W...... 435 Wang, Hao-Ven ...... 921 Webster, Micah T...... 1246 Voisine, Cindy ...... 56 Wang, Jie ...... 106 Wedig, Tatjana ...... 2345 Volkening, Kathryn ...... 123 Wang, Jian ...... 917, 1208 Wedlich-Soldner, Roland ...... 96, 443, 2063 Volker, Sonja E...... 1603 Wang, Jiping ...... 1928 Wee, Won Ryang ...... 1829 Volkmann, Niels ...... 2422 Wang, Jushuo ...... 724 Weeraratne, Shyamal D...... 289, 783 Volkov, Vladimir A...... 1645 Wang, Jean J...... 1489 Wegener, Kate L...... 59 Voog, Justin ...... 2445 Wang, Kai ...... 858, 1404 Wegner, Adam M...... 2400 Voronina, Vera A...... 1825 Wang, Liangli ...... 1239 Wei, Chih-Jen ...... 1124 255 AUTHOR INDEX The American Society for Cell Biology 47th Annual Meeting December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

Wei, Ho-Chun ...... 982 Wiebe, Matthew ...... 1249 Wong, Wai Lee T...... 1358 Wei, Jen-Hsuan ...... 1507 Wieckowski, Mariusz ...... 515 Wong, Yao L...... 391 Wei, Qize ...... 1032 Wiedeman, Alice ...... 490 Woo, Eileen M...... 115 Wei, Shuo ...... 1075 Wiegraebe, Winfried ...... 1939 Woo, JuHyung ...... 1864 Wei, Wan-Ju ...... 616 Wieschaus, Eric ...... 2058 Woo, Mi Kyoung ...... 2184 Weichert, Rachel M...... 1134 Wiese, Christiane ...... 995, 1249, 1437 Wood, Adam ...... 555, 1839 Weidberg, Hilla ...... 1106 Wiesenfahrt, Tobias ...... 2362 Wood, Thomas G...... 549 Weidner, Earl ...... 791 Wigle, Jeffrey T...... 1903 Woodman, Philip G...... 1727 Weiger, Michael ...... 420 Wignall, Sarah M...... 635 Woods, Brandon J...... 1241 Weigert, Roberto ...... 294, 1119, 2090 Wilde, Andrew ...... 1513 Woodward, John T...... 310 Weill, Claire O...... 1200 Wilgo, Matthew ...... 213, 214 Woolford, John ...... 1730 Weinberg, Ellen O...... 1837 Wilhelmsson, Ulrika ...... 39 Woolner, Sarah ...... 955 Weinberg, Richard J...... 49 Wilke, Sarah K...... 638 Wordeman, Linda ...... 746, 1644 Weinberger, Ron P...... 442, 936 Wilkes, David E...... 490 Workman, Benjamin G...... 2204 Weinreb, Gabriel E...... 702, 1012 Wilkins, Robert ...... 592 Workman, Jerry L...... 2412 Weins, Astrid ...... 1095 Willard, Stacey S...... 415, 664 Worman, Howard J...... 38, 1228 Weinstein, John ...... 2441 Willemsen, Rob ...... 454 Worth, Sarah ...... 45, 1268 Weis, Karsten ...... 840 Williams, Jeff ...... 1413A Wozniak, Michele A...... 1757, 2419 Weisel, Naama ...... 35 Williams, Janice A...... 1678, 2099 Wozniak, Marcin J...... 1727 Weisman, Gary ...... 409 Williams, John C...... 497 Wozniak, Richard W...... 1965 Weisman, Lois S...... 695 Williams, Lee ...... 1413A Wright, Amanda ...... 2293 Weiss, Robert S...... 2059 Williams, Phoebe ...... 1075 Wright, Melissa K...... 225 Weisz, Lilach ...... 1201, 1202 Willinger, Tim ...... 1608 Wright, Robin ...... 174, 175, 1742 Weisz, Ora A...... 1113, 2083, 2125 Wilmington, Shameika R...... 1248, 2360 Wu, Albert ...... 113 Weitz, David A...... 836, 935 Wilson, Emily ...... 1741 Wu, Amy ...... 113 Weitz, Ori ...... 1609 Wilson, Joshua D...... 165 Wu, Bingbing ...... 808 Welch, Emily ...... 1804 Wilson, Jamie L...... 1285 Wu, Chia-Mao ...... 1354 Welch, Matthew D...... 31 Wilson, Katherine L...... 1250, 1945 Wu, Chen-Tu ...... 1529 Weller, Shaun ...... 2007 Wilson, Leslie ...... 1449, 1463 Wu, Chieh-Hsi J...... 599 Wells, Alan ...... 693 Wilson, Patricia D...... 1786, 1830 Wu, Di ...... 1032 Wells, Amber L...... 22 Wilson, Patricia G...... 386 Wu, David ...... 1516 Wells, Rebecca G...... 2199 Wilson, Scott M...... 1373 Wu, Ed X...... 570 Welsh, Michelle ...... 2023 Winckler, Bettina ...... 1978, 1979 Wu, Guangyu ...... 285, 2116 Welsh, Michael J...... 463 Winco, Wu W. H...... 1960 Wu, Hao ...... 1163 Welte, Michael A...... 718, 1734 Windoffer, Reinhard ...... 2346, 2362 Wu, Hong ...... 2284 Wemmer, Kimberly A...... 985 Windschiegl, Barbara ...... 831 Wu, Jianchun ...... 1451 Wen, Cheng-Ho ...... 599 Winey, Mark ...... 623, 970, 971, 1508 Wu, Junjie ...... 1798 Wen, Kuo-Kuang ...... 2368 Winstall, Eric ...... 91 Wu, Julie A...... 2026 Wen, Shu-Fang ...... 1371 Winter, Jennifer R...... 1495, 1496 Wu, June H...... 1833 Wendland, Beverly R...... 292, 655, 1099, 2081, 2092 Wipf, Peter ...... 675 Wu, Leeying ...... 1375 Weng, Jing-Ru ...... 599 Wirschell, Maureen ...... 975, 976 Wu, Lianzheng ...... 595 Weninger, Keith ...... 272 Wirtz, Denis ...... 1047 Wu, Ning ...... 798 Wente, Susan R...... 133, 844 Wiseman, Sam M...... 1473 Wu, Pei-Rung ...... 1529 Wenthold, Robert J...... 771 Wissler, Josef H...... 124 Wu, Pei-Fung ...... 2283 Wentz-Hunter, Kelly ...... 1752 Witkin, Keren L...... 1245 Wu, Quan ...... 1535 Werb, Zena ...... 68, 96, 546, 1582, 1616 Witman, George B...... 452, 990 Wu, Qian ...... 659, 662 Werbin, Jeffrey L...... 1788 Wittmann, Torsten ...... 753 Wu, Shang-Ru ...... 1858 Werner, John ...... 850 Wloga, Dorota ...... 2396 Wu, Wenlin ...... 1283 Werner, Michael E...... 314, 2417 Woellert, Torsten ...... 468 Wu, Xunwei ...... 1051 Wessel, Gary M...... 2052, 2055 Wohland, Thorsten ...... 1707 Wu, Xufeng S...... 696 Westerhoff, Paul ...... 85 Wojcik, Edward J...... 382 Wu, Yi-Chun ...... 2351 Westermann, Stefan ...... 1645 Wolberger, Cynthia ...... 817 Wu, Yin ...... 570 Wevrick, Rachel ...... 2036 Wolf, Yuri I...... 862 Wu, Yi I...... 1408 Whagmare, Sanjeev ...... 238 Wolfe, Benjamin A...... 667, 2159 Wu, Zheng’an ...... 134 Wheatley, Christine L...... 296 Wolfel, Markus ...... 2404 Wulf, Phebe ...... 48 Wheelock, Margaret J...... 352, 887, 1584 Wolff, Iris M...... 1388 Wulfrum, Uwe ...... 1224 Whelan, Ellena ...... 2163 Wolff, Linda ...... 237 Wunderlich, Z ...... 747 Whigham, Benjamin ...... 1741 Wolfner, Mariana F...... 190 Wurst, Helmut ...... 1191 Whisenhunt, Thomas R...... 858 Wolfson, Marina ...... 1471 Wyckoff, Jeffrey ...... 1472 White, Erin A...... 254, 2389 Wolkoff, Allan W...... 1677 White, John G...... 167, 1045, 1520, 2249 Wolkow, Thomas ...... 628 X White, Judith M...... 1075 Wollman, Roy ...... 1488 Xhai, Ira ...... 1747 White, Michael ...... 1892 Wolniak, Stephen M...... 131, 1458 Xi, Fengong ...... 266 White, Thomas W...... 909, 911, 112 Won, Minho ...... 1562, 1860, 1863, 1865 Xia, Chun-Hong ...... 1123 Whitfi eld, Michael L...... 1512, 1545 Wonderlin, William F...... 168 Xia, Peng ...... 1116 Whittaker, Charles ...... 1075 Wong, Catherine C. L...... 862 Xia, Yu ...... 57 Whyte, Jacqueline A...... 1490, 1766 Wong, Elissa W. P...... 897 Xian, Wa ...... 2185 Wiche, Gerhard ...... 1376, 1778, 2363 Wong, Marianna ...... 1546 Xiang, Jim ...... 2190 Wick, Sue ...... 1749 Wong, Randall ...... 1151 Xiang, Xin ...... 1670 Widestrand, Asa ...... 39 Wong, Vivianne ...... 1065 Xiao, Kanyan ...... 353 Widlund, Per ...... 1644 Wong, Wei ...... 1822 Xiao, Shiyun ...... 1061 256 The American Society for Cell Biology 47th Annual Meeting AUTHOR INDEX December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

Xiao, Zhen ...... 885 Yanamadala, V ...... 1606 Yeo, Chang-Yeol ...... 682, 1298 Xie, Dong ...... 1358 Yang, Chuen-Mao ...... 1171 Yeo, Myoung Gu ...... 1781 Xie, Fei ...... 1175 Yang, Cheng-Wei Yang ...... 1354 Yeung, Tony Y...... 1082, 1284 Xie, Jun ...... 787, 1377, 1378 Yang, Chun-song ...... 1876 Yewdell, William ...... 629 Xie, Linfeng ...... 2204, 2246 Yang, Chun ...... 973 Yeykal, Caitlyn C...... 929 Xie, T...... 1606 Yang, Dong-Hua ...... 379 Yi, Kexi ...... 2258 Xie, Ting ...... 2446 Yang, Hyn Sook ...... 681 Yi, Zhaohong ...... 771 Xie, Yang ...... 1502 Yang, Huibin ...... 772 Yih-Fung, Chen ...... 592 Xing, Chengguo ...... 2211 Yang, Jingping ...... 106 Yim, Yang-In ...... 1101 Xiong, Gege ...... 737 Yang, Joy ...... 1808 Yin, Hang ...... 2451 Xiong, Xiaoling ...... 1701 Yang, Jongwock ...... 247 Yin, Jia ...... 2181 Xiong, Yi ...... 1434 Yang, Keum-Jin ...... 1562, 1860, 1863 Yin, Shengyong ...... 1125 Xu, Chen ...... 720 Yang, Meng S...... 2025 Ylänne, Jari ...... 59 Xu, Daosong ...... 882 Yang, Michael T...... 233 Yoneda, Aki ...... 1800 Xu, Eugene ...... 2054 Yang, Ning ...... 2416 Yonemura, Shigenobu ...... 653 Xu, Fang ...... 2089 Yang, Peter ...... 1091 Yoo, Seung H...... 1948 Xu, Fengfeng ...... 675 Yang, Pan-Chyr ...... 1861 Yoo, Young Do ...... 1872 Xu, Ren ...... 1230, 2418 Yang, Pinfen ...... 973 Yoon, Hana ...... 1240 Xu, Rener ...... 716 Yang, Qien ...... 2016 Yoon, Hye-Young ...... 2279 Xu, Shang-Zhi ...... 1882 Yang, Ru ...... 672 Yoon, Jongseo ...... 1853 Xu, Tian ...... 716 Yang, Seong Kyeong ...... 1167 Yoon, Joonho ...... 1352, 2184 Xu, Tao ...... 862 Yang, Shiqi ...... 77, 338, 344, 2273 Yoon, Joon-Kee ...... 247 Xu, Xin ...... 1124 Yang, Shaomin ...... 348, 349, 350, 595 Yoon, Min-A ...... 551 Xu, Zhen ...... 1161 Yang, Soojeong ...... 683 Yoon, Wan-Hee ...... 673, 674, 1560, 2155, 2290 Xue, Fei ...... 1417 Yang, Vivian C...... 2086 Yoon, Yisang ...... 1287, 1290 Xue, Xiuhua ...... 1700 Yang, Weidong ...... 843 Yoshida, Minoru ...... 1362 Xuebiao, Yao ...... 2237 Yang, Xiao Ping ...... 151 Yoshida, Satoshi ...... 23 Yang, Yang ...... 1162 Yoshida, Sei ...... 303 Y Yang, Yong ...... 2233 Yoshida, Toshimichi ...... 328, 375 Yadav, Marshleen ...... 1319 Yang, Yoon Sun ...... 572 Yoshikawa, Kiwamu ...... 1218 Yagagisawa, Makoto ...... 1069 Yang, Yizeng ...... 72 Yoshimura, Kazunori ...... 2015 Yamada, Hidenori ...... 1366, 2197 Yang, Yi ...... 960, 961, 965 Yoshimura, Koichi ...... 514 Yamada, Kaori H...... 1724 Yang, Zhongying ...... 1156 Yoshimura, Shige H...... 1949, 1959 Yamada, Kenneth M...... 1407, 1793 Yang, Zhong ...... 2025 Yoshimura, Takashi ...... 874 Yamada, Masayasu ...... 1477 Yang, Zhenye ...... 644 Yoshioka, Kiyoko ...... 1469 Yamada, Masashi ...... 1585 Yankel, Christine D...... 1444 Yoshizaki, Kotaro ...... 397 Yamada, Masafumi D...... 380, 390 Yano, Junji ...... 289 You, Min ...... 106 Yamada, Shigeru ...... 788 Yano, Shuichiro ...... 1530 Youle, Richard J...... 802, 1279 Yamada, Soichiro ...... 905 Yanowitz, Judith L...... 2056 Young, Carmen ...... 144 Yamagata, Natsumi ...... 875 Yao, Jianhui ...... 2233 Young, J’Nelle S...... 435 Yamagata, Yuriko ...... 1379 Yao, Tso-Pang ...... 2329 Young, Kevin ...... 945, 993 Yamagishi, Toshiyuki ...... 2019 Yao, Xuebiao ...... 1116, 1325, 1505, 1535, 2233 Young, Mary ...... 468 Yamaguchi, Hideki ...... 811, 1472 Yao, Yuan ...... 1009 Young, Stephen G...... 1254 Yamaguchi, Noriko ...... 1218 Yao, Yun ...... 1266 Young, Suzanne R. L...... 1780 Yamaguchi, R...... 801 Yap, Alpha S...... 2306 Yu, Fu-shin ...... 2181 Yamaguchi, Tetsuo ...... 712 Yap, Chan Choo ...... 1978, 1979 Yu, Gang ...... 187 Yamaguchi, Takahiro ...... 73 Yarar, Defne ...... 1096 Yu, Hanry ...... 2264 Yamakita, Yoshihiko ...... 2206 Yarden, Oded ...... 2265 Yu, Hoi-Ying E...... 482 Yamamoto, Akitsugu ...... 1256 Yarmola, Elena G...... 476 Yu, Juehua ...... 716 Yamamoto, Takaharu ...... 2130 Yasuda, Kenji ...... 899 Yu, Jianxin A...... 997 Yamamoto, Takuya ...... 604 Yasui, Akira ...... 1234 Yu, Jerry H...... 443, 96 Yamane, Junko ...... 1997 Yasumura, Thomas ...... 910 Yu, Jiang Z...... 2338 Yamane, Miho ...... 1951 Yates, Cecelia C...... 693 Yu, Li-Rong ...... 15, 1559 Yamashiro, Sawako ...... 1016, 1018 Yates, John R...... 667, 862, 1392, Yu, Ningpu ...... 409 Yamashiro, Shigeko ...... 2206 1431, 1436, 1631, 1668 Yu, Qianru ...... 1931 Yamashita, Atsushi ...... 574 Yazaki, Junshi ...... 1630 Yu, Qian-Chun ...... 72 Yamashita, Motozo ...... 1559 Ye, Bing ...... 46 Yu, Robert K...... 1069 Yamashita, Yukiko M...... 226 Ye, Mao ...... 1956 Yu, Sean ...... 106 Yan, Feng ...... 1535 Ye, Tianzhang ...... 1956 Yu, Tianzheng ...... 1287 Yan, Jizhou ...... 585 Yeager, John J...... 1169 Yu, Wenqian ...... 2294 Yan, Jinchun ...... 615 Yeaman, Charles ...... 2125 Yu, Xue ...... 1116 Yan, Lianying ...... 1135, 1136 Yee, Kelly ...... 1803 Yu, Ying ...... 1582 Yan, Mingda ...... 184 Yefremov, Artem ...... 2207 Yuan, Chao-xing ...... 585 Yan, Qingshang ...... 1694 Yeh, Byung-Il ...... 1352, 2184 Yuan, Kai ...... 1505 Yan, Shaofeng ...... 1307 Yeh, John ...... 2051 Yuan, Libin ...... 1087 Yan, Yuling ...... 1932 Yeh, Sheng-wen ...... 1529 Yuanjie, Li ...... 584 Yanagida, Mitsuhiro ...... 1493 Yeh, Ting-Yu ...... 1669 Yuba-Kubo, Akiko ...... 1997 Yanagisawa, Masahiro ...... 368, 895 Yemets, Alla I...... 1459, 1462, 2334 Yue, Peng ...... 267 Yanagisawa, Teruyuki ...... 1291, 283, 776 Yen, Timothy J...... 16, 1499, 1547 Yukich, John ...... 981 Yanai, Kazuhiko ...... 776 Yen, Yi-Meng ...... 1970 Yun, Eun Jin ...... 673, 674, 1560, 2155, 2290 Yanai, Ryoji ...... 864, 896 Yengo, Christopher M...... 1693 Yun, Sung Ji ...... 421, 603 257 AUTHOR INDEX The American Society for Cell Biology 47th Annual Meeting December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

Yurchenco, Peter ...... 379 Zhao, Jasmine ...... 585 Zhuang, Yuan ...... 716 Yuseff, María-Isabel ...... 996, 2101 Zhao, XuanNv ...... 1325 Zhuang, Zhenwu ...... 1307 Yuspa, Stuart H...... 872 Zhao, Yanqiu ...... 2096 Zhudenkov, Kirill ...... 2207 Zhao, Yu ...... 2132 Zidovska, Alexandra ...... 1488 Z Zhapparova, Olga N...... 1664 Ziegler, Andreas ...... 1219 Zaarour, Rania F...... 967 Zheng, Bin ...... 1532 Zieglgänsberger, Walter ...... 1261 Zad, Monica ...... 1389 Zheng, Bo ...... 208, 210 Zigler, Jr., J. S...... 2364 Zaghloul, Norann A...... 1813 Zheng, Grace X. Y...... 2439 Zimmerman, Seth ...... 146 Zagon, Ian S...... 1364, 1365, 2153, 2187, 2188 Zheng, Hui-Ye ...... 1390 Zimmerman, Sandra G...... 189 Zahir, Nastaran ...... 314 Zheng, Li ...... 1838 Zimmermann, L. T...... 1323 Zaidi, Syed K...... 1221 Zheng, Shusen ...... 684 Zinshteyn, Daniel E...... 1573 Zala, Diana ...... 1607 Zheng, Ya-Li ...... 2350 Zipfel, Warren R...... 1010 Zallen, Jennifer A...... 1609 Zheng, Yali ...... 600 Zitzmann, Nicole ...... 748 Zamft, Brad ...... 1295 Zheng, Yixian ...... 650, 1436, 2394 Ziv, Carmit ...... 2265 Zanta, Carolyn A...... 1741 Zhong, Bihui ...... 2353, 2354 Ziv, Ehud ...... 501 Zareno, Jessica ...... 475 Zhong, Franklin L...... 1251 Zizza, Pasquale ...... 2117 Zastrow, Michael S...... 1945 Zhong, Weimin ...... 2450 Zolan, Miriam E...... 638 Zawada, W. M...... 590 Zhou, Jian ...... 2032 Zoncu, Roberto ...... 829, 1111, 2094 Zawistowski, Jon S...... 402 Zhou, Meng-Ning ...... 437 Zones, James M...... 14 Zbornik, Erica ...... 948 Zhou, Qin ...... 2352, 2354 Zorniak, Michael ...... 1892 Zebroski, Henry ...... 862 Zhou, Qiongqiong ...... 415, 664 Zou, Jianxuan ...... 1370 Zedek, Daniel ...... 596 Zhou, Zhongjun ...... 570 Zou, Yaqun ...... 1899 Zeitlin, Samantha G...... 1489 Zhou-Yu, Jiang ...... 2435 Zuccolo, Michela ...... 1547 Zelenka, Peggy S...... 2313 Zhu, Fuxiang ...... 306 Zuchero, J. Bradley ...... 2391 Zelter, Alex ...... 1644 Zhu, Jianmei ...... 573 Zucker, Robert S...... 2401 Zeng, Juan ...... 1376 Zhu, Lian ...... 1216 Zucker, Shoshanna N...... 912 Zeng, Qi ...... 1085 Zhu, Lei ...... 651 Zuckerman, David M...... 2077 Zeng, Xiao ...... 104 Zhu, Mei ...... 1391, 1709, 2237 Zuercher, David ...... 547 Zenisek, David ...... 2402 Zhu, Nannan ...... 1839 Zukowska, Zofi a ...... 617 Zerfas, Patricia ...... 2305 Zhu, S...... 2270 Zulys, Matthew ...... 1284 Zerial, Marino ...... 1984 Zhu, Shanshan ...... 847 Zuo, Xiaofeng ...... 267 Zha, Xiaohui ...... 1009 Zhu, Weijia ...... 371 Zurat, Whitney K...... 225 Zhai, Zhonghe ...... 1542 Zhu, Xueliang ...... 2394 Zweifach, Adam ...... 1118 Zhan, Ke ...... 1880 Zhu, Zhiqing ...... 757 Zwolak, Jason ...... 2148 Zhang, An-Sheng ...... 516 Zhuang, Lei ...... 1670 Zhang, Aiping ...... 600 Zhang, Chao ...... 11 Zhang, Chuanmao ...... 1542 Zhang, Cuili ...... 1818 Zhang, Dong ...... 641 Zhang, Fangliang ...... 2378, 469 Zhang, Fan ...... 549 Zhang, Fengxue ...... 858, 1404 Zhang, Guofeng ...... 810 Zhang, Hao ...... 445 Zhang, Hui ...... 1542 Zhang, Hong ...... 16 Zhang, Jiuli ...... 1438 Zhang, Jin ...... 1531 Zhang, Jun ...... 1670 Zhang, Jiayin ...... 2226 Zhang, Jian ...... 266 Zhang, Liping ...... 1388 Zhang, Lei ...... 1925 Zhang, Mingjie ...... 1163 Zhang, Qiuping ...... 1651 Zhang, Wei ...... 1423, 2162 Zhang, Xihui ...... 1162 Zhang, Xiang-Dong ...... 16 Zhang, Xin ...... 2264 Zhang, Xiaoyu ...... 266 Zhang, Xiaochang ...... 716 Zhang, Yan ...... 1309 Zhang, Yang ...... 85 Zhang, Yingfan ...... 2309 Zhang, Ye ...... 46 Zhang, Ying ...... 238, 790, 1220, 1559, 2449 Zhang, Yuchao ...... 186 Zhang, Yuguo ...... 867 Visit the ASCB Booth! Zhang, Zhong-Hua ...... 278 Zhao, Jiangang ...... 242 258 The American Society for Cell Biology 47th Annual Meeting AUTHOR INDEX December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

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259 AUTHOR INDEX The American Society for Cell Biology 47th Annual Meeting December 1–5, 2007 Q Washington, DC Q [email protected] Q www.ascb.org

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