SnapShot: Actin Regulators II Anosha D. Siripala and Matthew D. Welch Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
Representative Proteins Protein Family H. sapiens D. melanogaster C. elegans A. thaliana S. cerevisiae Endocytosis and Exocytosis
ABP1/drebrin mABP1, drebrin, drebrin- †Q95RN0 †Q9XUT0 Abp1 like
EPS15 EPS15 Eps-15 EHS-1 †Q56WL2 Pan1
HIP1R HIP1R †Q8MQK1 †O62142 Sla2
Synapsin synapsin Ia, Ib, IIa, IIb, III Synapsin SNN-1 Plasma Membrane Association
Anillin anillin Scraps ANI-1, 2, 3
Annexins annexin A1–11, 13 (actin Annexin B9-11 NEX-1–4 ANN1-8 binding: 1, 2, 6)
ERM proteins ezrin, radixin, moesin DMoesin ERM-1
MARCKS MARCKS, MRP/ Akap200 MACMARCKS/F52
Merlin *merlin/NF2 Merlin NFM-1
Protein 4.1 4.1R, G, N, B Coracle
Spectrin α-spectrin (1–2), β-spectrin α-spectrin, β-spectrin, β heavy- SPC-1 (α-spectrin), UNC-70 (1–4), β heavy-spectrin/ spectrin/Karst (β-spectrin), SMA-1 (β heavy- karst spectrin) Identifi ed Cellular Role: X Membrane traffi cking and phagocytosis Cell-Cell Junctions X Cytokinesis α-catenin α-catenin 1–3 α-catenin HMP-1 X Cell surface organization and dynamics X Cell adhesion Afadin afadin/AF6 Canoe AFD-1 X Multiple functions ZO-1 ZO-1, ZO-2, ZO-3 ZO-1/Polychaetoid †Q56VX4 X Other/unknown
Cell-Extracellular Matrix Junctions †UNIPROT database accession number *Mutation linked to human disease Dystrophin/utrophin *dystrophin, utrophin/ Dystrophin DYS-1 DRP1, DRP2
LASP LASP-1, LASP-2, LIM- Lasp †P34416 nebulette
Palladin palladin
Parvin α-, β-, χ-parvin †Q9VWD0 PAT-6 (α-parvin)
Plakins BPAG1, MACF1, plectin Shortstop/Kakapo VAB-10 †Q8S8J6, Q38843, Q9C7V7
Talin talin 1–2 Rhea/Tendrils †Q22860
Tensin tensin 1–3 Blistery/Tensin †P92160
Vinculin vinculin Vinculin DEB-1
Zyxin/paxillin zyxin, paxillin Zyx102, Dpax ZYX-1, paxillin (†Q09476) Motor Proteins and Regulators
Caldesmon caldesmon Crtp
Calponin calponin 1–3 Chd64 CPN-1–4 Scp1
Myosin family Myosin types 1, 2, 3, *5, *6, Myosin types 1, 2, 3, 5, 6, 7, Myosin types 1, 2, 5, 6, 7, 9, 12 Myosin types 8, 11 Myosin types 1, 2, 5 *7, 9, 10, *15, 16, 18, 19 15, 18, 20
Tropomyosin tropomyosin 1, *2, *3, 4 Tm1, Tm2 LEV-11/TMY-1 †Q8LE98 Tpm1, Tpm2
Troponin troponin T*1, *2, 3; C1, 2; Troponin T/Upheld, Troponin TNI-1-4, TNC-1-2, TNT-1-4 I1, 2, *3 I/Wings up, Troponin C1-3, Tina-1 Muscle Components
Myopalladin myopalladin, *myotilin
Nebulin *nebulin, *nebulette, N-RAP Nebulin †P34416
Titin/connectin *titin/connectin D-titin, Projectin/Twitchin Ce-titin, stretchin Nuclear Actin-Associated Proteins
Chromatin-remodeling BAF, PBAF, TIP60, p400 BAP Ino80, NuA4 complexes
hnRNP proteins DBP40 (R. norvegicus) hrp36, hrp65 (C. tentans)
Nuclear DNA Helicase II NDHII Maleless/MLE RHA-1
See online version for references and abbreviations. Actin Regulators I appeared in the February 9 issue of Cell. 1014 Cell 128, March 9, 2007 ©2007 Elsevier Inc. DOI 10.1016/j.cell.2007.02.021 SnapShot: Actin Regulators II Anosha D. Siripala and Matthew D. Welch Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
References
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Abbreviations
ABP1: actin-binding protein 1 Akap200: A kinase anchor protein 200 BAF: BRG1-associated factor BAP: Brahma-associated protein BIN2: bridging integrator 2 BPAG1: bullous pemphigoid antigen 1 Crtp: caldesmon-related protein DBP40: DNA-binding protein 40 DRP1: dystrophin-related protein 1 DRP2: dystrophin-related protein 2 EPS15: epidermal growth factor receptor pathway substrate 15 HIP1R: huntingtin-interacting protein 1 related hrp: heterogeneous nuclear ribonucleoprotein LASP: Lim and SH3 protein MACF1: microtubule-actin crosslinking factor 1 MARCKS: myristoylated alanine-rich protein kinase C substrate MRP/MACMARCKS: MARCKS-related protein/macrophage MARCKS NDHII: nuclear DNA helicase II N-RAP: nebulin-related anchoring protein NF2: neurofibromin 2 NuA4: nucleosome acetyltransferase of H4 PBAF: polybromo-associated BRG1 associated factor TIP60: HIV-1 Tat-interacting protein of 60 kilodaltons ZO: zonula occludens
1014.e1 Cell 128, March 9, 2007 ©2007 Elsevier Inc. DOI 10.1016/j.cell.2007.02.021