SnapShot: Actin Regulators II Anosha D. Siripala and Matthew D. Welch Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA

Representative Proteins Protein Family H. sapiens D. melanogaster C. elegans A. thaliana S. cerevisiae Endocytosis and Exocytosis

ABP1/drebrin mABP1, drebrin, drebrin- †Q95RN0 †Q9XUT0 Abp1 like

EPS15 EPS15 Eps-15 EHS-1 †Q56WL2 Pan1

HIP1R HIP1R †Q8MQK1 †O62142 Sla2

Synapsin synapsin Ia, Ib, IIa, IIb, III Synapsin SNN-1 Plasma Membrane Association

Anillin anillin Scraps ANI-1, 2, 3

Annexins annexin A1–11, 13 (actin Annexin B9-11 NEX-1–4 ANN1-8 binding: 1, 2, 6)

ERM proteins ezrin, radixin, moesin DMoesin ERM-1

MARCKS MARCKS, MRP/ Akap200 MACMARCKS/F52

Merlin *merlin/NF2 Merlin NFM-1

Protein 4.1 4.1R, G, N, B Coracle

Spectrin α-spectrin (1–2), β-spectrin α-spectrin, β-spectrin, β heavy- SPC-1 (α-spectrin), UNC-70 (1–4), β heavy-spectrin/ spectrin/Karst (β-spectrin), SMA-1 (β heavy- karst spectrin) Identifi ed Cellular Role: X Membrane traffi cking and phagocytosis Cell-Cell Junctions X Cytokinesis α-catenin α-catenin 1–3 α-catenin HMP-1 X Cell surface organization and dynamics X Cell adhesion Afadin afadin/AF6 Canoe AFD-1 X Multiple functions ZO-1 ZO-1, ZO-2, ZO-3 ZO-1/Polychaetoid †Q56VX4 X Other/unknown

Cell-Extracellular Matrix Junctions †UNIPROT database accession number *Mutation linked to human disease Dystrophin/utrophin *dystrophin, utrophin/ Dystrophin DYS-1 DRP1, DRP2

LASP LASP-1, LASP-2, LIM- Lasp †P34416 nebulette

Palladin palladin

Parvin α-, β-, χ-parvin †Q9VWD0 PAT-6 (α-parvin)

Plakins BPAG1, MACF1, plectin Shortstop/Kakapo VAB-10 †Q8S8J6, Q38843, Q9C7V7

Talin talin 1–2 Rhea/Tendrils †Q22860

Tensin tensin 1–3 Blistery/Tensin †P92160

Vinculin vinculin Vinculin DEB-1

Zyxin/paxillin zyxin, paxillin Zyx102, Dpax ZYX-1, paxillin (†Q09476) Motor Proteins and Regulators

Caldesmon caldesmon Crtp

Calponin calponin 1–3 Chd64 CPN-1–4 Scp1

Myosin family Myosin types 1, 2, 3, *5, *6, Myosin types 1, 2, 3, 5, 6, 7, Myosin types 1, 2, 5, 6, 7, 9, 12 Myosin types 8, 11 Myosin types 1, 2, 5 *7, 9, 10, *15, 16, 18, 19 15, 18, 20

Tropomyosin tropomyosin 1, *2, *3, 4 Tm1, Tm2 LEV-11/TMY-1 †Q8LE98 Tpm1, Tpm2

Troponin troponin T*1, *2, 3; C1, 2; Troponin T/Upheld, Troponin TNI-1-4, TNC-1-2, TNT-1-4 I1, 2, *3 I/Wings up, Troponin C1-3, Tina-1 Muscle Components

Myopalladin myopalladin, *myotilin

Nebulin *nebulin, *nebulette, N-RAP Nebulin †P34416

Titin/connectin *titin/connectin D-titin, Projectin/Twitchin Ce-titin, stretchin Nuclear Actin-Associated Proteins

Chromatin-remodeling BAF, PBAF, TIP60, p400 BAP Ino80, NuA4 complexes

hnRNP proteins DBP40 (R. norvegicus) hrp36, hrp65 (C. tentans)

Nuclear DNA Helicase II NDHII Maleless/MLE RHA-1

See online version for references and abbreviations. Actin Regulators I appeared in the February 9 issue of Cell. 1014 Cell 128, March 9, 2007 ©2007 Elsevier Inc. DOI 10.1016/j.cell.2007.02.021 SnapShot: Actin Regulators II Anosha D. Siripala and Matthew D. Welch Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA

References

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Bretscher, A., Edwards, K., and Fehon, R.G. (2002). ERM proteins and merlin: Integrators at the cell cortex. Nat. Rev. Mol. Cell Biol. 3, 586–599.

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Clark, K.A., McElhinny, A.S., Beckerle, M.C., and Gregorio, C.C. (2002). Striated muscle cytoarchitecture: An intricate web of form and function. Annu. Rev. Cell Dev. Biol. 18, 637–706.

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Abbreviations

ABP1: actin-binding protein 1 Akap200: A kinase anchor protein 200 BAF: BRG1-associated factor BAP: Brahma-associated protein BIN2: bridging integrator 2 BPAG1: bullous pemphigoid antigen 1 Crtp: caldesmon-related protein DBP40: DNA-binding protein 40 DRP1: dystrophin-related protein 1 DRP2: dystrophin-related protein 2 EPS15: epidermal growth factor receptor pathway substrate 15 HIP1R: huntingtin-interacting protein 1 related hrp: heterogeneous nuclear ribonucleoprotein LASP: Lim and SH3 protein MACF1: microtubule-actin crosslinking factor 1 MARCKS: myristoylated alanine-rich protein kinase C substrate MRP/MACMARCKS: MARCKS-related protein/macrophage MARCKS NDHII: nuclear DNA helicase II N-RAP: nebulin-related anchoring protein NF2: neurofibromin 2 NuA4: nucleosome acetyltransferase of H4 PBAF: polybromo-associated BRG1 associated factor TIP60: HIV-1 Tat-interacting protein of 60 kilodaltons ZO: zonula occludens

1014.e1 Cell 128, March 9, 2007 ©2007 Elsevier Inc. DOI 10.1016/j.cell.2007.02.021