BSCB Newsletter 2019A:BSCB Aut2k7
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The Fourth Report of Senior Pay and Perks in UK Universities History This
Transparency at the top? The fourth report of senior pay and perks in UK universities History This is the fourth report on pay and perks at the top of British higher education institutions (HEIs) to be published by the University and College Union (UCU). It forms part of the union’s ongoing campaign for greater transparency in higher education, including the rationale behind senior pay rises. UCU submitted a Freedom of Information (FoI) request to 158 HEIs in October 2017. This followed similar requests submitted in 2016, 2015 and 2014. All requests were designed to shine a light on the arbitrary nature of senior pay and perks in universities, and support the union’s call for reform. The basis for this report The FoI request that forms the basis of this report was sent to 158 (HEIs). It requested details of vice-chancellors’ (or head of institution if known by a different title) salaries and those of other senior post-holders earning over £100,000 at the institution during the academic year of 2016/17 (1 August 2016 to 31 July 2017). It also asked for details of flights, spending on hotels, spending on expenses and if the vice-chancellor was provided with accommodation by the university. Finally, we requested to know whether or not the vice-chancellor was a member of the remuneration committee, and requested a copy of the most recently ratified minutes of the institution’s remuneration committee. Variety of responses The questions on expenditure on flights, hotels, expenses and accommodation for vice-chancellors elicited a huge variation in responses with many institutions deploying exemptions under the Freedom of Information Act to avoid providing data. -
Dynamical Gene Regulatory Networks Are Tuned by Transcriptional Autoregulation with Microrna Feedback Thomas G
www.nature.com/scientificreports OPEN Dynamical gene regulatory networks are tuned by transcriptional autoregulation with microRNA feedback Thomas G. Minchington1, Sam Grifths‑Jones2* & Nancy Papalopulu1* Concepts from dynamical systems theory, including multi‑stability, oscillations, robustness and stochasticity, are critical for understanding gene regulation during cell fate decisions, infammation and stem cell heterogeneity. However, the prevalence of the structures within gene networks that drive these dynamical behaviours, such as autoregulation or feedback by microRNAs, is unknown. We integrate transcription factor binding site (TFBS) and microRNA target data to generate a gene interaction network across 28 human tissues. This network was analysed for motifs capable of driving dynamical gene expression, including oscillations. Identifed autoregulatory motifs involve 56% of transcription factors (TFs) studied. TFs that autoregulate have more interactions with microRNAs than non‑autoregulatory genes and 89% of autoregulatory TFs were found in dual feedback motifs with a microRNA. Both autoregulatory and dual feedback motifs were enriched in the network. TFs that autoregulate were highly conserved between tissues. Dual feedback motifs with microRNAs were also conserved between tissues, but less so, and TFs regulate diferent combinations of microRNAs in a tissue‑dependent manner. The study of these motifs highlights ever more genes that have complex regulatory dynamics. These data provide a resource for the identifcation of TFs which regulate the dynamical properties of human gene expression. Cell fate changes are a key feature of development, regeneration and cancer, and are ofen thought of as a “land- scape” that cells move through1,2. Cell fate changes are driven by changes in gene expression: turning genes on or of, or changing their levels above or below a threshold where a cell fate change occurs. -
Womencount: Leaders in Higher Education 2016
WomenCount Leaders in Higher Education 2016 A report by Norma Jarboe OBE ‘There’s no magic about getting a good gender balance – just dogged repetition of what a high priority it is and a determination to seek out strong women candidates who could hold their own against any competition.’ WomenCount ‘If universities inhibit the progression of talented female staff, they in turn are unable to reach their full potential. We know that universities make a huge contribution to society through research, teaching and partnerships with businesses, among many other activities.’ Professor Dame Athene Donald, Professor of Experimental Physics and Master of Churchill College, University of Cambridge WomenCount are very grateful to Perrett Laver for their support, the Government Equalities Office for their enagagement and Imperial College London for hosting the launch of this report on 2 March 2016. Cover quotation: Sir Nicholas Montagu, Chair of Council, Queen Mary University of London. Published by WomenCount © March 2016, all rights reserved. www.women-count.org Designed and produced by Graffeg. WomenCount: Leaders in Higher Education 2016 Contents 3 Foreword 4 Executive summary 5 Introduction 6 Collective action 9 Collegial governance: diversity challenge or opportunity? 10 Governing bodies: women’s representation on the rise 11 Governing bodies: the balancing act 12 Chairs: few seats for women 14 Vice-Chancellors: barely a fifth are women 15 Chair and Vice-Chancellor teams 16 Executive teams: a pipeline of women leaders 17 Academic heads: less than a third are women 19 HEI income impact women’s leadership 21 Mapping Women’s Leadership in HEIs 22 Reflections on the research 27 The Index 37 Biographies of new Chairs 42 Biographies of new Vice-Chancellors 47 About WomenCount and the author 1 Foreword ‘Gender equality is not a matter of being nice to women. -
Mothers in Science
The aim of this book is to illustrate, graphically, that it is perfectly possible to combine a successful and fulfilling career in research science with motherhood, and that there are no rules about how to do this. On each page you will find a timeline showing on one side, the career path of a research group leader in academic science, and on the other side, important events in her family life. Each contributor has also provided a brief text about their research and about how they have combined their career and family commitments. This project was funded by a Rosalind Franklin Award from the Royal Society 1 Foreword It is well known that women are under-represented in careers in These rules are part of a much wider mythology among scientists of science. In academia, considerable attention has been focused on the both genders at the PhD and post-doctoral stages in their careers. paucity of women at lecturer level, and the even more lamentable The myths bubble up from the combination of two aspects of the state of affairs at more senior levels. The academic career path has academic science environment. First, a quick look at the numbers a long apprenticeship. Typically there is an undergraduate degree, immediately shows that there are far fewer lectureship positions followed by a PhD, then some post-doctoral research contracts and than qualified candidates to fill them. Second, the mentors of early research fellowships, and then finally a more stable lectureship or career researchers are academic scientists who have successfully permanent research leader position, with promotion on up the made the transition to lectureships and beyond. -
BSCB Newsletter 2017D
2017 BSCB Newsletter BRITISH SOCIETY FOR CELL BIOLOGY Meet the new BSCB President Royal Opening of the Crick Meeting reports 2017 CONTENTS BSCB Newsletter News 2 Book reviews 7 Features 8 Meeting Reports 24 Summer students 30 Society Business 33 Editorial Welcome to the 2017 BSCB newsletter. After several meeting hosted several well received events for our Front cover: years of excellent service, Kate Nobes has stepped PhD and Postdoc members, which we discuss on The head of a Drosophila pupa. The developing down and handed the reins over to me. I’ve enjoyed page 5. Our PhD and Postdoc reps are working hard compound eye (green) is putting together this years’ newsletter. It’s been great to make the event bigger and better for next year! The composed of several hundred simple units called ommatidia to hear what our members have been up to, and I social events were well attended including the now arranged in an extremely hope you will enjoy reading it. infamous annual “Pub Quiz” and disco after the regular array. The giant conference dinner. Members will be relieved to know polyploidy cells of the fat body (red), the fly equivalent of the The 2016 BSCB/DB spring meeting, organised by our we aren’t including any photos from that here. mammalian liver and adipose committee members Buzz Baum (UCL), Silke tissue, occupy a big area of the Robatzek and Steve Royle, had a particular focus on In this issue, we highlight the great work the BSCB head. Cells and Tissue Architecture, Growth & Cell Division, has been doing to engage young scientists. -
Analysis of Murine Homeobox Genes Anthony Graham
ANALYSIS OF MURINE HOMEOBOX GENES ANTHONY GRAHAM Thesis for the Degree of Doctor of Philosophy Division of Eukaryotic Molecular Genetics National In s titu te fo r Medical Research The Ridgeway, M ill H ill London NW7 1AA Univeristy College London Gower Street London WC1E 6BT November, 1989 ProQuest Number: 10611102 All rights reserved INFORMATION TO ALL USERS The quality of this reproduction is dependent upon the quality of the copy submitted. In the unlikely event that the author did not send a com plete manuscript and there are missing pages, these will be noted. Also, if material had to be removed, a note will indicate the deletion. uest ProQuest 10611102 Published by ProQuest LLC(2017). Copyright of the Dissertation is held by the Author. All rights reserved. This work is protected against unauthorized copying under Title 17, United States C ode Microform Edition © ProQuest LLC. ProQuest LLC. 789 East Eisenhower Parkway P.O. Box 1346 Ann Arbor, Ml 48106- 1346 This thesis is dedicated to my mother and father. i i The work in this thesis is original except where stated. The sequences used for comparisons in Chapter 3 were not determined by the author but were either from publications from other laboratories or from other members of the laboratory. Anthony Graham: ABSTRACT The work in this thesis is consistent with , and strengthens, suggestions that murine homeobox genes play a role in the establishment of regional specification. It is shown that there is a correlation between the physical order of members of the Hox 2 cluster and their order of expression along the rostrocaudal axis, such that each more 3' gene is expressed more rostrally. -
Perspective Lecture, Frankfurt February 14Th 2013 Professor Paul
Professor Paul Workman Bio: Perspective Lecture, Frankfurt February 14 th 2013 Professor Paul Workman – Short Biography Professor Paul Workman is a leader in the discovery and development of molecularly targeted cancer drugs and is a passionate advocate of personalized cancer therapy. A molecular pharmacologist and chemical biologist, Paul has been responsible for the discovery and development of a large number of new molecularly targeted cancer drugs. Paul is currently Deputy Chief Executive of The Institute of Cancer Research (ICR) and Director of the ICR’s Cancer Research UK Cancer Therapeutics Unit in Sutton, UK, which is the largest non-profit cancer drug discovery group worldwide. He is also Head of ICR’s Division of Cancer Therapeutics and Harrap Professor of Pharmacology and Therapeutics. Paul obtained his BSc (Hons) in Biochemistry from Leicester University (1973) and his PhD in Cancer Pharmacology from Leeds University (1977). He then moved to Cambridge to become a postdoctoral fellow and scientific staff member of the MRC Clinical Oncology Unit, MRC Centre, Cambridge University (1976-1990) where he established and led the cancer pharmacology group, making major contributions to drugs targeting tumour hypoxia. Following a period as UICC Visiting Fellow at Stanford University and SRI International, California (1989), Paul was appointed as Cancer Research Campaign Professor and Director of Laboratory Research in the Department of Medical Oncology, Beatson Laboratories, Glasgow University (1990-1993). Paul then gained experience in the pharmaceutical industry. From 1993-1997 Paul was Head of the Cancer Research Bioscience Section at AstraZeneca Pharmaceuticals, Alderley Park, UK where he also initiated and led the strategic alliance with Sugen. -
Feedback Interactions Between Cell–Cell Adherens Junctions and Cytoskeletal Dynamics in Newt Lung Epithelial Cells□V Clare M
Molecular Biology of the Cell Vol. 11, 2471–2483, July 2000 Feedback Interactions between Cell–Cell Adherens Junctions and Cytoskeletal Dynamics in Newt Lung Epithelial Cells□V Clare M. Waterman-Storer,*†‡ Wendy C. Salmon,†‡ and E.D. Salmon‡ *Department of Cell Biology and Institute for Childhood and Neglected Diseases, The Scripps Research Institute, La Jolla, California 92037; and ‡Department of Biology, University of North Carolina, Chapel Hill, North Carolina 27599 Submitted February 3, 2000; Revised April 20, 2000; Accepted May 11, 2000 Monitoring Editor: Jennifer Lippincott-Schwartz To test how cell–cell contacts regulate microtubule (MT) and actin cytoskeletal dynamics, we examined dynamics in cells that were contacted on all sides with neighboring cells in an epithelial cell sheet that was undergoing migration as a wound-healing response. Dynamics were recorded using time-lapse digital fluorescence microscopy of microinjected, labeled tubulin and actin. In fully contacted cells, most MT plus ends were quiescent; exhibiting only brief excursions of growth and shortening and spending 87.4% of their time in pause. This contrasts MTs in the lamella of migrating cells at the noncontacted leading edge of the sheet in which MTs exhibit dynamic instability. In the contacted rear and side edges of these migrating cells, a majority of MTs were also quiescent, indicating that cell–cell contacts may locally regulate MT dynamics. Using photoactivation of fluorescence techniques to mark MTs, we found that MTs in fully contacted cells did not undergo retrograde flow toward the cell center, such as occurs at the leading edge of motile cells. Time-lapse fluorescent speckle microscopy of fluorescently labeled actin in fully contacted cells revealed that actin did not flow rearward as occurs in the leading edge lamella of migrating cells. -
Situación Actual Y Perspectivas De Futuro Personalized Precision Oncology: Current Status and Future Perspectives Madrid, 21 Y 22 De Marzo / March 21-22, 2019
Simposio Internacional International Symposium Oncología personalizada de precisión: situación actual y perspectivas de futuro Personalized Precision Oncology: current status and future perspectives Madrid, 21 y 22 de marzo / March 21-22, 2019 BIO Paul Workman Professor Paul Workman FMedSci, FRS is Chief Executive and President of The Institute of Cancer Research (ICR). Professor Workman is a passionate advocate of personalised molecular medicine and is an enthusiastic practitioner of multidisciplinary cancer drug discovery and development approaches to 'drugging the cancer genome'. He also conceptualised the 'Pharmacological Audit Trail' approach. As well as establishing and successfully leading drug discovery project teams yielding clinical candidates, Professor Workman’s personal and collaborative research utilises molecular pharmacology and chemical biology approaches, including high-throughput and genome-wide as well as hypothesis- driven strategies, to interrogate cancer biology, identify and validate new drug targets, discover and develop chemical tools and drugs acting on these targets, identify predictive and mechanism of action biomarkers, and elucidate mechanisms of drug sensitivity of resistance. He is especially interested in exploiting the addictions, vulnerabilities and dependencies of cancer cells using a combination of small molecule tools and drugs alongside molecular genetic techniques. Professor Workman has successfully built a series of multidisciplinary drug discovery and development teams in the academic, large pharma and biotechnology company sectors. Through this experience he has been able to combine the best elements of each of these environments. He has been responsible for the discovery of a number of drug development candidates, including in particular pathfinding inhibitors of the HSP90 molecular chaperone and the PI3 kinase family of signalling enzymes. -
1 Genomic Analysis of Family Data Reveals Additional Genetic Effects On
bioRxiv preprint doi: https://doi.org/10.1101/106203; this version posted February 6, 2017. The copyright holder for this preprint (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. Genomic analysis of family data reveals additional genetic effects on intelligence and personality W. David Hill1,2*†, Ruben C. Arslan3,4†, Charley Xia†5, Michelle Luciano1,2, Carmen Amador5, Pau Navarro5, Caroline Hayward5, Reka Nagy5, David J. Porteous1,6,8, Andrew M. McIntosh1,9, Ian J. Deary1,2, Chris S. Haley5,10, and Lars Penke1,3,4 1 Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK 2 Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK 3 Georg Elias Müller Institute of Psychology, Georg August University Göttingen, Germany 4 Leibniz ScienceCampus Primate Cognition, Göttingen, Germany 5 MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK 6 Generation Scotland, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK 8 Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh 9 Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh EH10 5HF 10 The Roslin Institute and Royal (Dick) School of Veterinary Sciences, University of Edinburgh, UK * Corresponding author † These authors contributed equally Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK, T: +44 (131) 650 8405, E: [email protected] 1 bioRxiv preprint doi: https://doi.org/10.1101/106203; this version posted February 6, 2017. -
Reflections on the Historiography of Molecular Biology
Reflections on the Historiography of Molecular Biology HORACE FREELAND JUDSON SURELY the time has come to stop applying the word revolution to the rise of new scientific research programmes. Our century has seen many upheavals in scientific ideas--so many and so varied that the notion of scientific revolution has been stretched out of shape and can no longer be made to cover the processes of change characteristic of most sciences these past hundred years. By general consent, two great research pro- grammes arising in this century stand om from the others. The first, of course, was the one in physics that began at the turn of the century with quantum theory and relativity and ran through the working out, by about 1930, of quantum mechanics in its relativistic form. The trans- formation in physics appears to be thoroughly documented. Memoirs and biographies of the physicists have been written. Interviewswith survivors have been recorded and transcribed. The history has been told at every level of detail and difficulty. The second great programme is the one in biology that had its origins in the mid-1930s and that by 1970 had reached, if not a conclusion, a kind of cadence--a pause to regroup. This is the transformation that created molecular biology and latter-day biochemistry. The writing of its history has only recently started and is beset with problems. Accounting for the rise of molecular biology began with brief, partial, fugitive essays by participants. Biographies have been written of two, of the less understood figures in the science, who died even as the field was ripening, Oswald Avery and Rosalind Franklin; other scientists have wri:tten their memoirs. -
Papers Will Be Uploaded in Due Course
THE UNIVERSITY OF EDINBURGH BUSINESS FOR MEETING OF THE UNIVERSITY COURT to be held in the Raeburn Room, Old College on Monday, 9 December 2013 at 2.00 p.m. A buffet lunch will be available at 1.00 p.m. in the Lord Provost Elder Room, Old College This meeting of Court will be preceded by a presentation on the Research Excellence Framework (REF2014) delivered by Mrs Tracey Slaven, Deputy Secretary, Strategic Planning. A FORMAL BUSINESS 1. Minute of the meeting held on 4 November 2013 A1 2. Senate Assessor A2 B PRINCIPAL'S BUSINESS 1. Principal’s Communications B1 2. Vice-Principal update B2 C SUBSTANTIVE ITEMS 1. Report of the Finance and General Purposes Committee .1 Comments on the Report of the Central Management Group C1.1 .2 Report on Other Items C1.2 2. EUSA President’s Report C2 3. Risk Management Committee year end report C3 4. Risk Management – post year end Assurance Statement C4 5. Audit Committee Annual Report C5 6. Reports and Financial Statements .1 Annual Report and Accounts for year ended 31 July 2013 C6.1 .2 Letter of Representation C6.2 .3 Review of 2012/2013 Outturn versus Forecast C6.3 7. 2014-2017 Draft Outcome Agreement C7 8. Strategic Plan: Targets and KPIs Progress Report C8 9. Annual Review 2012-2013 C9 10. Report from Remuneration Committee C10 11. Report from Knowledge Strategy Committee C11 D ITEMS FOR FORMAL APPROVAL OR NOTE 1. Draft Resolutions D1 2. Risk Management Committee – Terms of Reference D2 3. Donations and Legacies D3 4.