Mercury Exposure and Child Development Outcomes
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Manganese and Its Compounds: Environmental Aspects
This report contains the collective views of an international group of experts and does not necessarily represent the decisions or the stated policy of the United Nations Environment Programme, the International Labour Organization, or the World Health Organization. Concise International Chemical Assessment Document 63 MANGANESE AND ITS COMPOUNDS: ENVIRONMENTAL ASPECTS First draft prepared by Mr P.D. Howe, Mr H.M. Malcolm, and Dr S. Dobson, Centre for Ecology & Hydrology, Monks Wood, United Kingdom The layout and pagination of this pdf file are not identical to the document in print Corrigenda published by 12 April 2005 have been incorporated in this file Published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organization, and the World Health Organization, and produced within the framework of the Inter-Organization Programme for the Sound Management of Chemicals. World Health Organization Geneva, 2004 The International Programme on Chemical Safety (IPCS), established in 1980, is a joint venture of the United Nations Environment Programme (UNEP), the International Labour Organization (ILO), and the World Health Organization (WHO). The overall objectives of the IPCS are to establish the scientific basis for assessment of the risk to human health and the environment from expos ure to chemicals, through international peer review processes, as a prerequisite for the promotion of chemical safety, and to provide technical assistance in strengthening national capacities for the sound management -
HISTORY of LEAD POISONING in the WORLD Dr. Herbert L. Needleman Introduction the Center for Disease Control Classified the Cause
HISTORY OF LEAD POISONING IN THE WORLD Dr. Herbert L. Needleman Introduction The Center for Disease Control classified the causes of disease and death as follows: 50 % due to unhealthy life styles 25 % due to environment 25% due to innate biology and 25% due to inadequate health care. Lead poisoning is an environmental disease, but it is also a disease of life style. Lead is one of the best-studied toxic substances, and as a result we know more about the adverse health effects of lead than virtually any other chemical. The health problems caused by lead have been well documented over a wide range of exposures on every continent. The advancements in technology have made it possible to research lead exposure down to very low levels approaching the limits of detection. We clearly know how it gets into the body and the harm it causes once it is ingested, and most importantly, how to prevent it! Using advanced technology, we can trace the evolution of lead into our environment and discover the health damage resulting from its exposure. Early History Lead is a normal constituent of the earth’s crust, with trace amounts found naturally in soil, plants, and water. If left undisturbed, lead is practically immobile. However, once mined and transformed into man-made products, which are dispersed throughout the environment, lead becomes highly toxic. Solely as a result of man’s actions, lead has become the most widely scattered toxic metal in the world. Unfortunately for people, lead has a long environmental persistence and never looses its toxic potential, if ingested. -
TOXICOLOGY and EXPOSURE GUIDELINES ______(For Assistance, Please Contact EHS at (402) 472-4925, Or Visit Our Web Site At
(Revised 1/03) TOXICOLOGY AND EXPOSURE GUIDELINES ______________________________________________________________________ (For assistance, please contact EHS at (402) 472-4925, or visit our web site at http://ehs.unl.edu/) "All substances are poisons; there is none which is not a poison. The right dose differentiates a poison and a remedy." This early observation concerning the toxicity of chemicals was made by Paracelsus (1493- 1541). The classic connotation of toxicology was "the science of poisons." Since that time, the science has expanded to encompass several disciplines. Toxicology is the study of the interaction between chemical agents and biological systems. While the subject of toxicology is quite complex, it is necessary to understand the basic concepts in order to make logical decisions concerning the protection of personnel from toxic injuries. Toxicity can be defined as the relative ability of a substance to cause adverse effects in living organisms. This "relative ability is dependent upon several conditions. As Paracelsus suggests, the quantity or the dose of the substance determines whether the effects of the chemical are toxic, nontoxic or beneficial. In addition to dose, other factors may also influence the toxicity of the compound such as the route of entry, duration and frequency of exposure, variations between different species (interspecies) and variations among members of the same species (intraspecies). To apply these principles to hazardous materials response, the routes by which chemicals enter the human body will be considered first. Knowledge of these routes will support the selection of personal protective equipment and the development of safety plans. The second section deals with dose-response relationships. -
Ethylene Glycol Ingestion Reviewer: Adam Pomerlau, MD Authors: Jeff Holmes, MD / Tammi Schaeffer, DO
Pediatric Ethylene Glycol Ingestion Reviewer: Adam Pomerlau, MD Authors: Jeff Holmes, MD / Tammi Schaeffer, DO Target Audience: Emergency Medicine Residents, Medical Students Primary Learning Objectives: 1. Recognize signs and symptoms of ethylene glycol toxicity 2. Order appropriate laboratory and radiology studies in ethylene glycol toxicity 3. Recognize and interpret blood gas, anion gap, and osmolal gap in setting of TA ingestion 4. Differentiate the symptoms and signs of ethylene glycol toxicity from those associated with other toxic alcohols e.g. ethanol, methanol, and isopropyl alcohol Secondary Learning Objectives: detailed technical/behavioral goals, didactic points 1. Perform a mental status evaluation of the altered patient 2. Formulate independent differential diagnosis in setting of leading information from RN 3. Describe the role of bicarbonate for severe acidosis Critical actions checklist: 1. Obtain appropriate diagnostics 2. Protect the patient’s airway 3. Start intravenous fluid resuscitation 4. Initiate serum alkalinization 5. Initiate alcohol dehydrogenase blockade 6. Consult Poison Center/Toxicology 7. Get Nephrology Consultation for hemodialysis Environment: 1. Room Set Up – ED acute care area a. Manikin Set Up – Mid or high fidelity simulator, simulated sweat if available b. Airway equipment, Sodium Bicarbonate, Nasogastric tube, Activated charcoal, IV fluid, norepinephrine, Simulated naloxone, Simulate RSI medications (etomidate, succinylcholine) 2. Distractors – ED noise For Examiner Only CASE SUMMARY SYNOPSIS OF HISTORY/ Scenario Background The setting is an urban emergency department. This is the case of a 2.5-year-old male toddler who presents to the ED with an accidental ingestion of ethylene glycol. The child was home as the father was watching him. The father was changing the oil on his car. -
Poison Hemlock G
Pasture Weed Fact Sheet W 325 Poison Hemlock G. Neil Rhodes, Jr., Professor and Extension Weed Management Specialist Trevor D. Israel, Extension Assistant Department of Plant Sciences Poison Hemlock Conium maculatum L. Classification and Description Poison hemlock, also called deadly hemlock, poison parsley, spotted hemlock, and California fern, is a highly poisonous bien- nial weed that is a member of the family Apiaceae, which is also referred to as the carrot family. It was originally introduced as a garden plant because of its attractive flowers. Other members of this family include wild carrot (Daucus carota L.), wild chervil (Anthriscus syvlestris (L.) Hoffm.), and a close relative to poison hemlock, water hemlock (Cicuta maculata L.). This native of Eurasia is found throughout Tennessee where it usually occurs in patches in cool-season grass pastures, roadsides, drainage ditches and stream banks. The cotyledons or seed leaves of seedlings are Fig. 1. Poison hemlock flowers in compound umbels. oblong-lanceolate, and the first true leaf is pinnately compound and glabrous. Flowers are small and white in large, compound umbels 1.5 to 2.4 inches wide (Fig. 1). The hollow stems of this plant are ridged, glabrous, and purple-spotted (Fig. 2). Leaves form a basal rosette; they are alternate upward, petioled, approxi- mately 8 to 16 inches long, broadly triangular-ovate, and com- pound. Leaflets are lanceolate to ovate-oblong, finely cut, less than 0.5 inch long. Crushed leaves have a mouse-like odor. Ma- ture plants can be 3 to 4 feet tall (Fig. 3) with fibrous roots branching from a turnip-like taproot (Fig. -
A Short History of Occupational Disease: 2. Asbestos, Chemicals
Ulster Med J 2021;90(1):32-34 Medical History A SHORT HISTORY OF OCCUPATIONAL DISEASE: 2. ASBESTOS, CHEMICALS, RADIUM AND BEYOND Petts D, Wren MWD, Nation BR, Guthrie G, Kyle B, Peters L, Mortlock S, Clarke S, Burt C. ABSTRACT OCCUPATIONAL CANCER Historically, the weighing out and manipulation of dangerous Towards the end of the 18th century, a possible causal link chemicals frequently occurred without adequate protection between chemicals and cancer was reported by two London from inhalation or accidental ingestion. The use of gloves, surgeons. In 1761, John Hill reported an association between eye protection using goggles, masks or visors was scant. snuff, a tobacco product, and nasopharyngeal cancer, From Canary Girls and chimney sweeps to miners, stone and, in 1775, Percival Pott described a high incidence of cutters and silo fillers, these are classic exemplars of the subtle scrotal cancer in chimney sweeps. Pott, a surgeon at St (and in some cases not so subtle) effects that substances, Bartholomew’s Hospital in London, published his findings,6 environments and practices can have on individual health. which he attributed to contamination with soot. This excellent INTRODUCTION epidemiological study is considered to be the first report of a potential carcinogen. Pott’s work led to the foundation of It has been known for many centuries that certain diseases occupational medicine and to the Chimney Sweep Act of were associated with particular occupations (i.e. wool- 1788. In 1895, Ludwig Reyn reported that aromatic amines sorters disease in the textile industry, cowpox in milk maids used in certain dye industries in Germany were linked and respiratory problems in miners and stone workers). -
Mercury Spill Fact Sheet
This fact sheet is intended to be a quick reference tool for people who are involved in a mercury spill and cleanup event. MERCURY Mercury mercury MERCURY MERCURY MERCURY Elemental mercury, also called “quicksilver,” is a heavy, silvery, form of the metal mercury that is liquid at room temperature. It can slowly change from a liquid into a gas that is invisible to the naked eye. The gas or “vapors” that are released will start to fill a room if mercury is spilled indoors. MERCURY EXPOSURE Mercury is a very toxic or poisonous substance that people can be exposed to in several ways. If it is swallowed, like from a broken thermometer, it mostly passes through your body and very little is absorbed. If you touch it, a small amount may pass through your skin, but not usually enough to harm you. Mercury is most harmful when you breathe in the vapors that are released when a container is open or a spill occurs. HEALTH EFFECTS Pregnant women, infants and young children are particularly sensitive to the harmful effects of mercury. The health effects that can result from mercury exposure depend on how much mercury you are exposed to and how long you are exposed. Some of the acute effects, ones that may come soon after exposure to high concentrations of mercury are: • Headaches, chills, fever • chest tightness, coughs • hand tremors • nausea, vomiting, abdominal cramps, diarrhea Some effects that may result from chronic, or longer term exposure to mercury vapor can be: • Personality changes • Decreased vision or hearing • Peripheral nerve damage • Elevated blood pressure Children are especially sensitive to mercury and at risk of developing a condition known as acrodynia or “Pinks Disease” by breathing vapors or other exposure circumstances. -
Poison Hemlock (Conium Maculatum)
KING COUNTY NOXIOUS WEED ALERT Class B Noxious Weed: Poison Hemlock Control Required on Conium maculatum Parsley Family Public Lands and Roads Identification Tips • Tall biennial, reaching 8 to 10 feet the second year • Bright green, fernlike leaves with strong musty smell • First year plants form low clumps of lacy leaves with reddish spots on stems • Second year stems are stout, hollow, hairless, ribbed, with reddish or purple spotting/streaking • Flowering plants covered with numerous small, umbrella-shaped clusters of tiny white flowers that have five petals • Seeds form in green, ridged capsules that eventually turn brown Poison-hemlock has bright green, fern- like leaves with a musty smell. Biology Reproduces by seed. First year grows into a rosette; second year, develops tall stems and flowers. Rapid growth from March to May, flowers in late spring. Up to 40,000 seeds per plant are produced. Seeds fall near the plant and are moved by erosion, animals, rain and human activity. Seeds viable up to 6 years and germinate throughout the growing season; do not require a dormant period. Impacts Acutely toxic to people, livestock, wildlife; causes death by Thick, hairless stems have reddish- respiratory paralysis after ingestion. Aggressive growth crowds out purple spots or streaks. desirable vegetation. Early spring growth makes it more likely to be eaten by animals when there is limited forage available. Can be mistaken for a carrot when small. Distribution Eurasian species, widely found in North America. Widespread in King County; found along roadsides, riparian areas, ravines, fields, ditches and un-managed yards and vacant lots. -
Material Safety Data Sheet
MATERIAL SAFETY DATA SHEET Prepared to U.S. OSHA, CMA, ANSI and Canadian WHMIS Standards PART I What is the material and what do I need to know in an emergency? 1. PRODUCT IDENTIFICATION TRADE NAME (AS LABELED) : MERCURY CHEMICAL NAME/CLASS : Mercury; Element SYNONYMS: Colloidal Mercury, Quick Silver; Liquid Silver; NCI-C60399; Hydrargyrum PRODUCT USE : Variety of industrial, analytical, and research applications. SUPPLIER/MANUFACTURER'S NAME : COMPANY ADDRESS : DFG MERCURY CORP 909 pitner Evanston Ill 60202 EMERGENCY PHONE : 1 800 424 9300 BUSINESS PHONE : 1 847 869 7800 DATE OF PREPARATION : May 20, 1997 DATE OF REVISION : October 7, 2013 2. COMPOSITION and INFORMATION ON INGREDIENTS CHEMICAL NAME CAS # %w/w EXPOSURE LIMITS IN AIR ACGIH-TLV OSHA-PEL OTHER TWA STEL TWA STEL IDLH mg/m 3 mg/m 3 mg/m 3 mg/m 3 mg/m 3 mg/m 3 Mercury 7439-97-6 100 0.025, (skin) NE Mercury 0.1 (ceiling) 10 NIOSH REL: Exposure limits are A4 (Not Vapor: 0.5, STEL = 0.1 (ceiling, for Mercury, Classifiable Skin; Non-alkyl Mercury skin) Inorganic as a Human (Vacated Compounds: 0.1 DFG MAKs: Compounds Carcinogen) 1989 PEL) Ceiling, skin TWA = 0.1 (Vacated 1989 PEAK = 10 •MAK 30 PEL) min., momentary value Carcinogen: EPA-D; IARC-3, TLV-A4 NE = Not Established. See Section 16 for Definitions of Terms Used. NOTE: ALL WHMIS required information is included in appropriate sections based on the ANSI Z400.1-1998 format. This product has been classified in accordance with the hazard criteria of the CPR and the MSDS contains all the information required by the CPR. -
Complete Issue (PDF)
Abstracts Eliminating Occupational Disease: areas in the country. The study studied 40 small scale industries, and collected 40 water samples (potable) for cyanide and mer- Translating Research into Action cury which are used in mining. Questionnaire-guided interviews EPICOH 2017 and work analysis covering mining practices and risk exposures were conducted, as well as chemical analysis through gas chro- 28–31 August 2017, Edinburgh, UK matography. Results of the study showed unsafe conditions in the industries such as risk of fall during erection and dismantling of scaffolds, guard rails were not provided in scaffoldings, man- Poster Presentation ual extraction of underground ores, use of explosives, poor visi- bility in looking for ores to take out to surface, exposure to Pesticides noise from explosives, and to dust from the demolished struc- tures. Mine waste was drained into soil or ground and/or rivers and streams. The most common health problems among miners 0007 ASSESSMENT OF PESTICIDE EXPOSURE AND were hypertension (62%), followed by hypertensive cardiovascu- OCCUPATIONAL SAFETY AND HEALTH OF FARMERS IN lar disease due to left wall ischemia (14%). Health symptoms THE PHILIPPINES such as dermatitis, and peripheral neuropathy were noted and Jinky Leilanie Lu. National Institutes of Health, Institute of Health Policy and Development these can be considered as manifestations of chronic cyanide poi- Studies, University of the Philippines Manila, Manila, The Philippines soning, further, aggravated by improper use of protective equip- ment. For the environmental samples of potable water, 88% and 10.1136/oemed-2017-104636.1 98% were positive with mercury and cyanide respectively. About 52% of drinking water samples exceeded the TLV for mercury Aims This is a study conducted among 534 farmers in an while 2% exceeded the TLV for cyanide. -
At Work in the World
Perspectives in Medical Humanities At Work in the World Proceedings of the Fourth International Conference on the History of Occupational and Environmental Health Edited by Paul D. Blanc, MD and Brian Dolan, PhD Page Intentionally Left Blank At Work in the World Proceedings of the Fourth International Conference on the History of Occupational and Environmental Health Perspectives in Medical Humanities Perspectives in Medical Humanities publishes scholarship produced or reviewed under the auspices of the University of California Medical Humanities Consortium, a multi-campus collaborative of faculty, students and trainees in the humanities, medi- cine, and health sciences. Our series invites scholars from the humanities and health care professions to share narratives and analysis on health, healing, and the contexts of our beliefs and practices that impact biomedical inquiry. General Editor Brian Dolan, PhD, Professor of Social Medicine and Medical Humanities, University of California, San Francisco (ucsf) Recent Monograph Titles Health Citizenship: Essays in Social Medicine and Biomedical Politics By Dorothy Porter (Fall 2011) Paths to Innovation: Discovering Recombinant DNA, Oncogenes and Prions, In One Medical School, Over One Decade By Henry Bourne (Fall 2011) The Remarkables: Endocrine Abnormalities in Art By Carol Clark and Orlo Clark (Winter 2011) Clowns and Jokers Can Heal Us: Comedy and Medicine By Albert Howard Carter iii (Winter 2011) www.medicalhumanities.ucsf.edu [email protected] This series is made possible by the generous support of the Dean of the School of Medicine at ucsf, the Center for Humanities and Health Sciences at ucsf, and a Multi-Campus Research Program grant from the University of California Office of the President. -
Small Dose... Big Poison
Traps for the unwary George Braitberg Ed Oakley Small dose... Big poison All substances are poisons; Background There is none which is not a poison. It is not possible to identify all toxic substances in a single The right dose differentiates a poison from a remedy. journal article. However, there are some exposures that in Paracelsus (1493–1541)1 small doses are potentially fatal. Many of these exposures are particularly toxic to children. Using data from poison control centres, it is possible to recognise this group of Poisoning is a frequent occurrence with a low fatality rate. exposures. In 2008, almost 2.5 million human exposures were reported to the National Poison Data System (NPDS) in the United Objective States, of which only 1315 were thought to contribute This article provides information to assist the general to fatality.2 The most common poisons associated with practitioner to identify potential toxic substance exposures in children. fatalities are shown in Figure 1. Polypharmacy (the ingestion of more than one drug) is far more common. Discussion In this article the authors report the signs and symptoms Substances most frequently involved in human exposure are shown of toxic exposures and identify the time of onset. Where in Figure 2. In paediatric exposures there is an over-representation clear recommendations on the period of observation and of personal care products, cleaning solutions and other household known fatal dose are available, these are provided. We do not discuss management or disposition, and advise readers products, with ingestions peaking in the toddler age group. This to contact the Poison Information Service or a toxicologist reflects the acquisition of developmental milestones and subsequent for this advice.