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GENE TECHNOLOGY FORUM 2001 September 13-15 TARTU, ESTONIA CONTENT Content Programme 5 Programm 8 Klaus Lindpaintner, "Impact of Genetics and Genomics on Health 11 VP and Director, Roche Genetics, Care: Opportunities and Challenges" F. Hoffmann-La Roche AG, Switzerland Andreas Braun, "From SNPs to Medical Utility" 13 Chief Medical Officer, Sequenom Inc., USA Dr. Roger B Derbyshire, "Large Scale SNP Genotyping using Primer 15 Associate Director, Orchid BioSciences Europe Ltd, UK Extension on Multiple Platforms: Determination of Genome Wide SNP Allele Frequency Map" Stanford (Ford) N. Goldman, Jr., "Capital Formation: From Start-up to IPO, The 17 Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C., American Experience" USA Ian Dunham, "The Human Genome Project" Sanger Centre, UK 19 Wojciech Makalowski, "Computational Genomics - Promises and Pensylvania State University, Pensylvania, USA 21 Challenges" Olli-P. Kallioniemi, Biochip Technologies in Cancer Research: National Human Genome Research Institute, National " 23 Institutes of Health, Bethesda, USA From Genome Screening to Identification of Therapeutic Targets" Erwin Schurr, McGill University, Montreal, Canada "Genetic Epidemiology of Tuberculosis 25 Susceptibility" David G. Wang, Executive Vice President, First Genetic Trust Inc., USA "Informatics and Genetics" 27 Mark S. Chee, "Accessing Genetic Information: Technology Vice President of Genomics, Illumina Inc., USA for Large Scale SNP Genotyping" 29 TM Rihard Grosse, "PHENOME : The Clinical Database for CEO, InGene, Germany Phenotype Driven Genotyping" 31 Andres Metspalu, "Estonian Genome Project: Current Status, Department of Biotechnology, University of Tartu, Permissive Technologies and Future Steps" 33 Estonia Kalev Kask, "Estonian Genome Project: From Candidate 35 Stanford University, USA Genes to Personalized Medicine" 3 GENE TECHNOLOGY FORUM 2001 TARTU, ESTONIA CONTENT Content Gisli Palsson, "For Whom the Cells Toll: Debates About 37 Director, Institute of Anthropology, University of Iceland, Biomedicine" Iceland Ralf Baumeister, "C.elegans, an Animal Model for the Functional 39 Genzentrum, Ludwig-Maximilians-Universität, München, Analysis of Human Disease Genes" Germany Cheng Chi Lee, "Mammalian Circadian Clock Genes" 41 Baylor College of Medicine, Houston, USA Charles Kurland, "Vanishing Genomes, Emergent Proteomes: 43 University of Lund, Sweden Evolving Mitochondria" Francois Cambien, "Genetics of Multifactorial Diseases" 45 Institut National de la Sante et de la Recherche Medicale (INSERM), Paris, France Stylianos E. Antonarakis, "Chromosome 21; a Small Genomic Land of 47 Department of Medical Genetics, University of Geneva, Fascinating Disorders" Switzerland Thomas Meitinger, "Complexity in Genetic Eye Disease" 49 Institute of Human Genetics, Neuherberg, Germany Massimo Carella, "The Genetics of Hearing Loss" 51 Telethon Institute of Genetics and Medicine (TIGEM), Napoli, Italy Nicholas J. Short, "Clinical Genomics and the Icelandic Cancer 53 CEO, UVS Iceland Genomics Corporation, Iceland Project" Mart Ustav, Department of Microbiology and Virology, University of "Gene Therapy and Gene Vaccination" 55 Tartu, Estonia Priit Kogerman, National Institute of Chemical Physics and Biophysics, "From Genes to Functions: the Case of CD44" 57 Tallinn, Estonia Giovanni Romeo, Unit of Genetic Susceptibility to Cancer, International "Genetics of Complex Diseases: the RET 59 Agency for Research on Cancer, Lyon, France Protooncogene and Thyroid Cancer" Notes 61 Acknowledgments 68 GENE TECHNOLOGY FORUM 2001 TARTU, ESTONIA 4 PROGRAMME Programme Thursday, Sept 13, 2001 18:00-18:45 Registration at the Vanemuine Concert Hall 18:45-19.00 OPENING Prof. Peeter Tulviste, Chairman of the Tartu City Council, Former Rector Magnificus of the University of Tartu, Estonia 19:00-20:00 OPENING SESSION Keynote Prof. Klaus Lindpaintner, Vice President and Director, Roche Genetics, F. Hoffmann-La Roche AG, Switzerland "Impact of Genetics and Genomics on Health Care: Opportunities and Challenges" 20:30 Welcome Reception hosted by University of Tartu in the Museum of Tartu University History Friday, Sept 14, 2001 8:30-9:00 Registration 9:00-11:00 SESSION I Chaired by Prof. Charles Kurland Dr. Andreas Braun, Chief Medical Officer, Sequenom Inc., USA "From SNPs to Medical Utility" Dr. Roger B Derbyshire, Associate Director, Orchid BioSciences Europe Ltd, UK "Large Scale SNP Genotyping using Primer Extension on Multiple Platforms: Determination of Genome Wide SNP Allele Frequency Map" Mr. Stanford (Ford) N. Goldman, Jr., Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C., USA "Capital Formation: From Start-up to IPO, The American Experience" 11:00-11:20 Coffee/tea break 11:20-12:35 SESSION II Chaired by Prof. Charles Kurland Dr. Ian Dunham, Sanger Centre, Hinxton, Cambridge, UK "The Human Genome Project" Dr. Wojciech Makalowski, Department of Biology and Institute of Molecular Evolutionary Genetics, Pennsylvania State University, Pennsylvania, USA "Computational Genomics - Promises and Challenges" 12:35-12:55 Coffee/tea break 5 GENE TECHNOLOGY FORUM 2001 TARTU, ESTONIA PROGRAMME Programme 12:55-14.05 SESSION III Chaired by Prof. Charles Kurland Dr. Olli-P. Kallioniemi, National Human Genome Research Institute, National Institutes of Health, Bethesda, USA "Biochip Technologies in Cancer Research: From Genome Screening to Identification of Therapeutic Targets" Prof. Erwin Schurr, McGill University, Montreal, Canada "Genetic Epidemiology of Tuberculosis Susceptibility" 14:05-15.10 Lunch 15:10-17:00 SESSION IV Chaired by Dr. Jaanus Pikani Dr. David G. Wang, Executive Vice President, First Genetic Trust Inc., USA "Informatics and Genetics" Dr. Mark S. Chee, Vice President of Genomics, Illumina Inc., USA "Accessing Genetic Information: Technology for Large Scale SNP Genotyping" Dr. Richard Grosse, CEO, InGene, Germany "PHENOMETM: The Clinical Database for Phenotype Driven Genotyping" 17:00-17:20 Coffee/tea break 17:20-19:00 SESSION V Chaired by Dr. Jaanus Pikani Prof. Andres Metspalu, Department of Biotechnology, University of Tartu, Estonia "Estonian Genome Project: Current Status, Permissive Technologies and Future Steps" Dr. Kalev Kask, Stanford University, USA "Estonian Genome Project: From Candidate Genes to Personalized Medicine" Prof. Gisli Palsson, Director, Institute of Anthropology, University of Iceland, Iceland "For Whom the Cells Toll: Debates About Biomedicine" 20:00 Buffet Dinner hosted by City of Tartu in the grand hall of the Ministry of Education Saturday, Sept 15, 2001 9:00-11:00 SESSION VI Chaired by Prof. Richard Villems Prof. Ralf Baumeister, Genzentrum, Ludwig-Maximilians-Universität, Munich, Germany "C.elegans, an Animal Model for the Functional Analysis of Human Disease Genes" GENE TECHNOLOGY FORUM 2001 TARTU, ESTONIA 6 PROGRAMME Programme Prof. Cheng Chi Lee, Baylor College of Medicine, Houston, USA "Mammalian Circadian Clock Genes" Prof. Charles Kurland, University of Lund, Sweden "Vanishing Genomes, Emergent Proteomes: Evolving Mitochondria" 11:00-11:20 Coffee/tea break 11:20-12:40 SESSION VII Chaired by Prof. Richard Villems Dr. Francois Cambien, Institut National de la Sante et de la Recherche Medicale (INSERM), France "Genetics of Multifactorial Diseases" Prof. Stylianos E. Antonarakis, Department of Medical Genetics, University of Geneva, Switzerland "Chromosome 21; a Small Genomic Land of Fascinating Disorders" 12:40-13:50 Lunch 13:50-15:10 SESSION VIII Chaired by Prof. Toivo Maimets Prof. Thomas Meitinger, Institute of Human Genetics, Neuherberg, Germany "Complexity in Genetic Eye Disease" Dr. Massimo Carella, Telethon Institute of Genetics and Medicine (TIGEM), Napoli, Italy "The Genetics of Hearing Loss" 15:10-15:30 Coffee break 15:30-17:40 SESSION IX Chaired by Prof. Toivo Maimets Dr. Nicholas J. Short, Chief Executive Officer, UVS Iceland Genomics Corporation, Iceland "Clinical Genomics and the Icelandic Cancer Project" Prof. Mart Ustav, Department of Microbiology and Virology, University of Tartu, Estonia "Gene Therapy and Gene Vaccination" Dr. Priit Kogerman, National Institute of Chemical Physics and Biophysics, Tallinn, Estonia. "From Genes to Functions: the Case of CD44" Prof. Giovanni Romeo, Director, Unit of Genetic Susceptibility to Cancer, International Agency for Research on Cancer, Lyon, France "Genetics of Complex Diseases: the RET Protooncogene and Thyroid Cancer" 17:40 Closing remarks 7 GENE TECHNOLOGY FORUM 2001 TARTU, ESTONIA PROGRAMM Programm Neljapäev, 13.september 2001 18:00-18:45 Osalejate registreerimine Vanemuise Kontserdimajas 18:45-19:00 AVAMINE Prof. Peeter Tulviste, Tartu Linnavolikogu esimees, endine Tartu Ülikooli rektor, Eesti 19:00-20:00 AVASESSIOON Põhiesineja Prof. Klaus Lindpaintner, asepresident ja direktor, Roche Genetics, F. Hoffmann-La Roche AG, Shveits "Geneetika ja genoomika mõju tervishoiule - võimalused ja väljakutsed" 20:30 Tervitusvastuvõtt Tartu Ülikooli Ajaloomuuseumis (sissepääs kutsetega) Reede, 14. september 2001 8:30-9:00 Osalejate registreerimine Vanemuise Kontserdimajas 9:00-11:00 ESIMENE SESSIOON Juhatab Prof. Charles Kurland Dr. Andreas Braun juhatuse esimees, Sequenom Inc., Ameerika Ühendriigid "Geneetilistelt markeritelt nende kasutamiseni meditsiinis" Dr. Roger B Derbyshire, asedirektor, Orchid BioSciences Europe Ltd, Suurbritannia "Suuremahuline genotüpiseerimine kasutades praimeri pikendamise tehnoloogia erinevaid võimalusi: Ülegenoomse SNP alleelide sageduse kaardi m’’ramine" Mr. Stanford (Ford) N. Goldman, Jr., Advokaadibüroo Mintz, Levin, Cohn, Ferris,
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