DOCSLIB.ORG

Immune Response of Hepatitis B Vaccine Among Persons with Diabetes a Systematic Review of the Literature

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Immune Response of Hepatitis B Vaccine Among Persons with Diabetes a Systematic Review of the Literature SYSTEMATIC REVIEW Immune Response of Hepatitis B Vaccine Among Persons With Diabetes A systematic review of the literature 1 SARAH F. SCHILLIE, MD among persons with diabetes show some 2 PHILIP R. SPRADLING, MD 1 heterogeneity compared with adults without TRUDY V. MURPHY, MD diabetes. Differences in diabetes type, man- agement, and glycemic control, as well as vaccine, dosage, administration route, or schedule, may underlie this heterogeneity. n October 2011, the Advisory Com- and other comorbid conditions (6–12). The 2011 ACIP recommendation for hepa- Imittee on Immunization Practices Results of studies of the hepatitis B vac- titis B vaccination for adults with diabetes, an (ACIP) recommended hepatitis B vac- cine among persons with diabetes gener- increasing incidence of diabetes, and the cination for adults with diabetes in the ally follow these patterns (13,14). high prevalence of diabetes among certain United States (1). Serosurvey data from Primary hepatitis B vaccination usu- groups recommended for hepatitis B vacci- the 1999–2010 National Health and Nu- ally consists of 3 (or 4) doses of 10 or nation (e.g., persons with end-stage renal trition Examination Survey found that 20 mg of recombinant hepatitis B surface disease) suggests that a review of vaccine ef- noninstitutionalized adults aged $18 antigen (HBsAg) protein administered in- ficacy among persons with diabetes may be years with diabetes have an increased se- tramuscularly into the deltoid muscle timely. We therefore performed a systematic roprevalence of past or current hepatitis B on a 0-, 1-, and 6-month schedule review of the literatureandsummarizedthe virus (HBV) infection (1). Outbreaks of (Table 1). Alternative schedules are U.S.- evidence for seroprotection after hepatitis B hepatitis B in elderly persons with diabe- approved for routine vaccination for spe- vaccination among persons with diabetes. tes in long-term care facilities have been cific ages and vaccine formulations, and fi fi linked to diabetes care procedures (in- they elicit dose-speci cand nal rates of RESEARCH DESIGN AND cluding blood glucose monitoring), with seroprotection similar to those obtained METHODS likely vehicles for transmission including on a 0-, 1-, and 6-month schedule (4). fi spring-loaded nger-stick devices used Two single-antigen recombinant vac- Search strategy on multiple patients and blood glucose cines, Recombivax HB (Merck & Co, Electronic searches of MEDLINE (via testing meters that were not cleaned be- Inc., Whitehouse Station, NJ) and PubMed), EMBASE (via Ovid), Cochrane tween uses on different patients. Engerix-B (GlaxoSmithKline Biologicals, Library, and Web of Knowledge databases In the U.S., hepatitis B vaccination is Rixensart, Belgium), and one combi- were performed. The search terms con- routinely recommended for infants, chil- nation hepatitis A/hepatitis B vaccine, sisted of (hepatitis b vaccin* OR hbv vac- dren, and adolescents. It also is recom- Twinrix (GlaxoSmithKline Biologicals), cin* OR hepatitis b immuni* OR hbv mended for adults at increased risk of are approved for use in adults in the U.S. immuni*) AND (immunogeni* OR im- HBV infection, including persons with (15). Hepatitis B vaccines are safe for all mune response OR antibody) AND (dia- end-stage renal disease or chronic liver age groups. Administration of additional betes). The search terms also were used as disease, health care personnel, injection- vaccine doses for nonresponders is not Medical Subject Heading terms (MEDLINE) drug users, and men who have sex with associated with an increase in adverse – or key words (EMBASE), as applicable. men (2 4). A hepatitis B vaccination se- events (16). Vaccination is not contrain- Where possible, limits included publica- ries results in protection in a high propor- dicated in persons with autoimmune or . tion date from 1986 through 30 April tion ( 95%) of infants, children, and chronic diseases, or in those who are 2012, English language, and study of hu- young adults (5). As with other vaccines, pregnant (4). mans. The MEDLINE and EMBASE the efficacy of the hepatitis B vaccine pro- No review has been published of the fi searches were limited to items containing gressively declines with advancing age, ef cacy of the hepatitis B vaccine among abstracts. Studies conducted in the U.S. and as well as with the presence of obesity persons with diabetes; results of studies other countries were eligible for inclusion. ccccccccccccccccccccccccccccccccccccccccccccccccc Inclusion criteria From the 1Division of Viral Hepatitis, Vaccine Research and Policy Team; National Center for HIV/AIDS, Viral Peer-reviewed, published randomized Hepatitis, STD, and TB Prevention; Centers for Disease Control and Prevention, Atlanta, Georgia; and the 2 clinical trials or observational studies (all Division of Viral Hepatitis, Epidemiology and Surveillance Branch; National Center for HIV/AIDS, Viral types) assessing response to hepatitis B Hepatitis, STD, and TB Prevention; Centers for Disease Control and Prevention, Atlanta, Georgia. Corresponding author: Sarah Schillie, [email protected]. vaccine among persons with type 1 or Received 13 February 2012 and accepted 6 June 2012. type 2 diabetes were included. Studies DOI: 10.2337/dc12-0312 among both children and adults were in- The findings and conclusions in this report are those of the author(s) and do not necessarily represent the cluded to ascertain the effect of age upon official position of the Centers for Disease Control and Prevention. © 2012 by the American Diabetes Association. Readers may use this article as long as the work is properly vaccine response among persons with cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/ diabetes. Reports had to specify the pro- licenses/by-nc-nd/3.0/ for details. portion (numerator and denominator) of 2690 DIABETES CARE, VOLUME 35, DECEMBER 2012 care.diabetesjournals.org Schillie, Spradling, and Murphy Table 1dRecommended dosages of hepatitis B vaccine for adults aged >20 years* (4) 85 duplicates were identified. Abstracts from the remaining 140 studies (62.2%) Single-antigen vaccine Combination vaccine were reviewed, and 94 (67.1%) were deemed not relevant. Forty-six (32.9%) Recombivax HB Engerix-B Twinrix full-text studies were retrieved and re- Dosage Volume Dosage Volume Dosage Volume viewed, and one additional duplicate was (mg) (mL) (mg) (mL) (mg) (mL) identified (Fig. 1). Fifteen studies did not fulfill inclusion criteria, and 13 met at Adults 10 1 20 1 20 1 least one criterion for exclusion (Table 2 Adult hemodialysis patients and other and Fig. 1), leaving 17 studies. † ‡ immunocompromised adults 40 140 2NANA The 17 studies included 2 random- NA, not applicable. *Please refer to package insert. †Dialysis formulation administered on a 3-dose schedule ized clinical trials, 12 prospective, and 3 at 0, 1, and 6 months. ‡Two 1-mL doses administered in 1 or 2 injections on a 4-dose schedule at 0, 1, 2, and 6 retrospective studies published between months. 1989 and 2012 (Table 3). The 17 studies included 16,310 unique subjects, of which approximately 9,286 had diabetes. subjects seroprotected by diabetes status publication year, country); subject charac- The subject categories consisted of adults (or data available that allowed for calcula- teristics (e.g., age, diabetes type); vaccine for 4 studies (285 subjects, of whom 152 tion of the proportions), or available odds characteristics (e.g., vaccine, dosage, had diabetes); children for 4 studies (472 ratios from a multivariate analysis, which route, schedule); and the proportion of subjects, of whom 206 had diabetes); and included diabetes as a predictor variable. subjects attaining seroprotection, includ- hemodialysis/chronic kidney disease pa- Studies of specific subject populations of ing the time interval (in months) from the tients for 9 studies (15,553 subjects, of which persons with diabetes represented a last dose at which immune response was whom approximately 8,928 had diabe- subset were included. measured. When vaccine or route of ad- tes). Subjects in the studies among adults ministration differed by study arm, extrac- and children generally lacked comorbid- Exclusion criteria tion elements were recorded for each arm ities (including kidney disease) other than Studies were excluded when immune when possible. diabetes. One study among hemodialysis/ response using an antibody to hepatitis An anti-HBs threshold of 10 mIU/mL chronic kidney disease patients included B surface antigen (anti-HBs) threshold of after series completion (an accepted only subjects with chronic kidney disease 10 mIU/mL was not reported; immune marker of immune protection) defined (i.e., no hemodialysis patients) (32), and response was not measured between seroprotection (4). When multiple im- three studies included both hemodialysis 0 and 6 months after the last vaccine mune response measurements were re- and chronic kidney disease patients dose (because anti-HBs titers wane over ported reflecting seroprotection at different (36,42,44), one of which also included time); 10 or fewer subjects with diabetes intervals during the primary vaccine se- peritoneal dialysis patients (44). The re- were included; vaccine was administered ries, the result after the final dose was re- mainder were comprised entirely of he- intradermally; or subjects were not naïve corded. When immune response was modialysis patients. Seroprotection to the vaccine or had positive serology for measured more than once after
Load more

Recommended publications
  • A Genetically Modified Dermal Micro-Organ Expressing Erythropoietin
    (19) & (11) EP 2 377 401 A1 (12) EUROPEAN PATENT APPLICATION (43) Date of publication: (51) Int Cl.: 19.10.2011 Bulletin 2011/42 A01N 63/00 (2006.01) A01N 65/00 (2009.01) C12N 5/00 (2006.01) C12N 5/02 (2006.01) (2010.01) (21) Application number: 11174205.2 C12N 5/071 (22) Date of filing: 29.04.2004 (84) Designated Contracting States: • Bukhman, Mordechay AT BE BG CH CY CZ DE DK EE ES FI FR GB GR 21891 Carmiel (IL) HU IE IT LI LU MC NL PL PT RO SE SI SK TR • Stern, Baruch, S. Designated Extension States: 34366 Haifa (IL) AL HR LT LV MK • Shalhevet, David 36090 Kiryat Tivon (IL) (30) Priority: 01.05.2003 US 466793 P • Shavitt, Menachem, D. 06.08.2003 US 492754 P 20142 D.N. Misgav (IL) • Pearlman, Andrew, L. (62) Document number(s) of the earlier application(s) in 20164 D.N. Miscav (IL) accordance with Art. 76 EPC: • Noam, Shani 04760621.5 / 1 653 807 30900 Zichron Yaakov (IL) • Almon, Einat (71) Applicant: Medgenics, Inc. 23840 Timrat (IL) Palo Alto, CA 94303 (US) (74) Representative: Modiano, Micaela Nadia (72) Inventors: Modiano & Partners • Bellomo, Stephen, F. Thierschstrasse 11 30900 Zichron Yaakov (IL) 80538 München (DE) • Lippin, Itzhak 42920 Moshav Beit Yitzhak (IL) Remarks: • Piva, Guillermo, Alberto This application was filed on 15-07-2011 as a Winston Salem, NC North Carolina 27104 (US) divisional application to the application mentioned • Rosenberg, Lior under INID code 62. 84965 Omer (IL) (54) A genetically modified dermal micro-organ expressing erythropoietin (57) The present invention is directed to a genetically cro-organ
    [Show full text]
  • Differential Gene Expression in Oligodendrocyte Progenitor Cells, Oligodendrocytes and Type II Astrocytes
    Tohoku J. Exp. Med., 2011,Differential 223, 161-176 Gene Expression in OPCs, Oligodendrocytes and Type II Astrocytes 161 Differential Gene Expression in Oligodendrocyte Progenitor Cells, Oligodendrocytes and Type II Astrocytes Jian-Guo Hu,1,2,* Yan-Xia Wang,3,* Jian-Sheng Zhou,2 Chang-Jie Chen,4 Feng-Chao Wang,1 Xing-Wu Li1 and He-Zuo Lü1,2 1Department of Clinical Laboratory Science, The First Affiliated Hospital of Bengbu Medical College, Bengbu, P.R. China 2Anhui Key Laboratory of Tissue Transplantation, Bengbu Medical College, Bengbu, P.R. China 3Department of Neurobiology, Shanghai Jiaotong University School of Medicine, Shanghai, P.R. China 4Department of Laboratory Medicine, Bengbu Medical College, Bengbu, P.R. China Oligodendrocyte precursor cells (OPCs) are bipotential progenitor cells that can differentiate into myelin-forming oligodendrocytes or functionally undetermined type II astrocytes. Transplantation of OPCs is an attractive therapy for demyelinating diseases. However, due to their bipotential differentiation potential, the majority of OPCs differentiate into astrocytes at transplanted sites. It is therefore important to understand the molecular mechanisms that regulate the transition from OPCs to oligodendrocytes or astrocytes. In this study, we isolated OPCs from the spinal cords of rat embryos (16 days old) and induced them to differentiate into oligodendrocytes or type II astrocytes in the absence or presence of 10% fetal bovine serum, respectively. RNAs were extracted from each cell population and hybridized to GeneChip with 28,700 rat genes. Using the criterion of fold change > 4 in the expression level, we identified 83 genes that were up-regulated and 89 genes that were down-regulated in oligodendrocytes, and 92 genes that were up-regulated and 86 that were down-regulated in type II astrocytes compared with OPCs.
    [Show full text]
  • Physiology G Endocrine
    2/28/18 Introduction • Endocrine system works with nervous system to coordinate body functions - Nervous system uses impulses and Endocrine System neurotransmitters - Endocrine system uses hormones • Many cells have receptors for both Chapter 24 neurotransmitters and hormones and can be regulated by both chemicals Copyright © 2016 by Elsevier Inc. All rights reserved. 1 Copyright © 2016 by Elsevier Inc. All rights reserved. 2 Comparing Endocrine and Introduction Nervous System Functions • Exocrine glands: Secrete products into ducts that open into body cavities - Sudoriferous: Secrete sweat - Sebaceous: Secrete oil - Ceruminous: Secrete ear wax • Endocrine glands - Secrete hormones directly into bloodstream - Ductless glands Copyright © 2016 by Elsevier Inc. All rights reserved. 3 Copyright © 2016 by Elsevier Inc. All rights reserved. 4 Major Endocrine Glands Anatomy • Hypothalamus • Pituitary • Pineal • Thyroid • Parathyroids • Adrenals • Pancreatic islets • Ovaries • Testes • Hormones From Koeppen BM: Berne & Levy Physiology, Updated Edition, ed 6, St. Louis, 2010, Mosby. Copyright © 2016 by Elsevier Inc. All rights reserved. 5 Copyright © 2016 by Elsevier Inc. All rights reserved. 6 1 2/28/18 Physiology Hormones and Regulation • Hormone production and secretion • Chemical messengers that regulate the • Regulation of metabolism physiologic activity of other cells • Stress adaptation • Have potential to come in contact with every • Chemical composition and fluid volume cell type regulation - Target cells are chemically compatible with
    [Show full text]
  • The Genetic Program of Pancreatic Beta-Cell Replication in Vivo
    Page 1 of 65 Diabetes The genetic program of pancreatic beta-cell replication in vivo Agnes Klochendler1, Inbal Caspi2, Noa Corem1, Maya Moran3, Oriel Friedlich1, Sharona Elgavish4, Yuval Nevo4, Aharon Helman1, Benjamin Glaser5, Amir Eden3, Shalev Itzkovitz2, Yuval Dor1,* 1Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel 2Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel. 3Department of Cell and Developmental Biology, The Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel 4Info-CORE, Bioinformatics Unit of the I-CORE Computation Center, The Hebrew University and Hadassah, The Institute for Medical Research Israel- Canada, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel 5Endocrinology and Metabolism Service, Department of Internal Medicine, Hadassah-Hebrew University Medical Center, Jerusalem 91120, Israel *Correspondence: [email protected] Running title: The genetic program of pancreatic β-cell replication 1 Diabetes Publish Ahead of Print, published online March 18, 2016 Diabetes Page 2 of 65 Abstract The molecular program underlying infrequent replication of pancreatic beta- cells remains largely inaccessible. Using transgenic mice expressing GFP in cycling cells we sorted live, replicating beta-cells and determined their transcriptome. Replicating beta-cells upregulate hundreds of proliferation- related genes, along with many novel putative cell cycle components. Strikingly, genes involved in beta-cell functions, namely glucose sensing and insulin secretion were repressed. Further studies using single molecule RNA in situ hybridization revealed that in fact, replicating beta-cells double the amount of RNA for most genes, but this upregulation excludes genes involved in beta-cell function.
    [Show full text]
  • Endocrine System
    Chapter 17 *Lecture PowerPoint The Endocrine System *See separate FlexArt PowerPoint slides for all figures and tables preinserted into PowerPoint without notes. Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. Introduction • In humans, two systems—the nervous and endocrine—communicate with neurotransmitters and hormones • This chapter is about the endocrine system – Chemical identity – How they are made and transported – How they produce effects on their target cells • The endocrine system is involved in adaptation to stress • There are many pathologies that result from endocrine dysfunctions 17-2 Overview of the Endocrine System • Expected Learning Outcomes – Define hormone and endocrine system. – Name several organs of the endocrine system. – Contrast endocrine with exocrine glands. – Recognize the standard abbreviations for many hormones. – Compare and contrast the nervous and endocrine systems. 17-3 Overview of the Endocrine System • The body has four principal mechanisms of communication between cells – Gap junctions • Pores in cell membrane allow signaling molecules, nutrients, and electrolytes to move from cell to cell – Neurotransmitters • Released from neurons to travel across synaptic cleft to second cell – Paracrine (local) hormones • Secreted into tissue fluids to affect nearby cells – Hormones • Chemical messengers that travel in the bloodstream to other tissues and organs 17-4 Overview of the Endocrine System • Endocrine system—glands, tissues, and cells that secrete hormones
    [Show full text]
  • Fibroblasts from the Human Skin Dermo-Hypodermal Junction Are
    cells Article Fibroblasts from the Human Skin Dermo-Hypodermal Junction are Distinct from Dermal Papillary and Reticular Fibroblasts and from Mesenchymal Stem Cells and Exhibit a Specific Molecular Profile Related to Extracellular Matrix Organization and Modeling Valérie Haydont 1,*, Véronique Neiveyans 1, Philippe Perez 1, Élodie Busson 2, 2 1, 3,4,5,6, , Jean-Jacques Lataillade , Daniel Asselineau y and Nicolas O. Fortunel y * 1 Advanced Research, L’Oréal Research and Innovation, 93600 Aulnay-sous-Bois, France; [email protected] (V.N.); [email protected] (P.P.); [email protected] (D.A.) 2 Department of Medical and Surgical Assistance to the Armed Forces, French Forces Biomedical Research Institute (IRBA), 91223 CEDEX Brétigny sur Orge, France; [email protected] (É.B.); [email protected] (J.-J.L.) 3 Laboratoire de Génomique et Radiobiologie de la Kératinopoïèse, Institut de Biologie François Jacob, CEA/DRF/IRCM, 91000 Evry, France 4 INSERM U967, 92260 Fontenay-aux-Roses, France 5 Université Paris-Diderot, 75013 Paris 7, France 6 Université Paris-Saclay, 78140 Paris 11, France * Correspondence: [email protected] (V.H.); [email protected] (N.O.F.); Tel.: +33-1-48-68-96-00 (V.H.); +33-1-60-87-34-92 or +33-1-60-87-34-98 (N.O.F.) These authors contributed equally to the work. y Received: 15 December 2019; Accepted: 24 January 2020; Published: 5 February 2020 Abstract: Human skin dermis contains fibroblast subpopulations in which characterization is crucial due to their roles in extracellular matrix (ECM) biology.
    [Show full text]
  • Downloaded at Google Indexer on July 22, 2021
    Downloaded by guest on October 1, 2021 Proc. Nati. Acad. Sci. USA Vol. 88, pp. 2603-2607, March 1991 Neurobiology Evidence for thymopoietin and thymopoietin/a-bungarotoxin/ nicotinic receptors within the brain M. QUIK*t, U. BABUf, T. AUDHYA*, AND G. GOLDSTEINt *Department of Pharmacology, McGill University, McIntyre Medical Building, 3655 Drummond Street, Montreal, Quebec H3G 1Y6, Canada; and timmunobiology Research Institute, Route 22 East, P.O. Box 999, Annandale, NJ 08801-0999 Communicated by Edward A. Boyse, December 20, 1990 ABSTRACT Thymopoietin, a polypeptide hormone of the These observations suggested that thymopoietin may repre- thymus that has pleiotropic actions on the immune, endocrine, sent an endogenous ligand for the nicotinic a-BGT-binding and nervous systems, potently interacts with the neuromuscu- site in brain; however, the identification of receptor-specific lar nicotinic acetylcholine receptor. Thymopoietin binds to the binding of radiolabeled thymopoietin to a site in brain that nicotinic a-bungarotoxin (a-BGT) receptor in muscle and, like also recognized a-BGT and nicotinic ligands would substan- a-BGT, inhibits cholinergic transmission at this site. Evidence tially support the above hypothesis. The present studies show is given that radiolabeled thymopoietin similarly binds to a that in brain 125I-thymopoietin binds in a specific manner to nicotinic a-BGT-binding site within the brain and does so with a receptor site that also interacts with nicotinic ligands and the characteristics of a specific receptor ligand. Thus specific a-BGT and, furthermore, that a constituent in brain extracts binding to neuronal membranes was saturable, of high affinity has the immunological reactivity and molecular mass of (Kd = 8 nM), linear with increased tissue concentration, and thymopoietin.
    [Show full text]
  • The Role of Lamin Associated Domains in Global Chromatin Organization and Nuclear Architecture
    THE ROLE OF LAMIN ASSOCIATED DOMAINS IN GLOBAL CHROMATIN ORGANIZATION AND NUCLEAR ARCHITECTURE By Teresa Romeo Luperchio A dissertation submitted to The Johns Hopkins University in conformity with the requirements for the degree of Doctor of Philosophy Baltimore, Maryland March 2016 © 2016 Teresa Romeo Luperchio All Rights Reserved ABSTRACT Nuclear structure and scaffolding have been implicated in expression and regulation of the genome (Elcock and Bridger 2010; Fedorova and Zink 2008; Ferrai et al. 2010; Li and Reinberg 2011; Austin and Bellini 2010). Discrete domains of chromatin exist within the nuclear volume, and are suggested to be organized by patterns of gene activity (Zhao, Bodnar, and Spector 2009). The nuclear periphery, which consists of the inner nuclear membrane and associated proteins, forms a sub- nuclear compartment that is mostly associated with transcriptionally repressed chromatin and low gene expression (Guelen et al. 2008). Previous studies from our lab and others have shown that repositioning genes to the nuclear periphery is sufficient to induce transcriptional repression (K L Reddy et al. 2008; Finlan et al. 2008). In addition, a number of studies have provided evidence that many tissue types, including muscle, brain and blood, use the nuclear periphery as a compartment during development to regulate expression of lineage specific genes (Meister et al. 2010; Szczerbal, Foster, and Bridger 2009; Yao et al. 2011; Kosak et al. 2002; Peric-Hupkes et al. 2010). These large regions of chromatin that come in molecular contact with the nuclear periphery are called Lamin Associated Domains (LADs). The studies described in this dissertation have furthered our understanding of maintenance and establishment of LADs as well as the relationship of LADs with the epigenome and other factors that influence three-dimensional chromatin structure.
    [Show full text]
  • Immune Cells in Spleen and Mucosa + CD127 Neg Production of IL-17 and IL-22 by CD3 TLR5 Signaling Stimulates the Innate
    Downloaded from http://www.jimmunol.org/ by guest on September 23, 2021 neg is online at: average * The Journal of Immunology , 23 of which you can access for free at: 2010; 185:1177-1185; Prepublished online 21 Immune Cells in Spleen and Mucosa from submission to initial decision + 4 weeks from acceptance to publication TLR5 Signaling Stimulates the Innate Production of IL-17 and IL-22 by CD3 CD127 Laurye Van Maele, Christophe Carnoy, Delphine Cayet, Pascal Songhet, Laure Dumoutier, Isabel Ferrero, Laure Janot, François Erard, Julie Bertout, Hélène Leger, Florent Sebbane, Arndt Benecke, Jean-Christophe Renauld, Wolf-Dietrich Hardt, Bernhard Ryffel and Jean-Claude Sirard June 2010; doi: 10.4049/jimmunol.1000115 http://www.jimmunol.org/content/185/2/1177 J Immunol cites 51 articles Submit online. Every submission reviewed by practicing scientists ? is published twice each month by http://jimmunol.org/subscription Submit copyright permission requests at: http://www.aai.org/About/Publications/JI/copyright.html Receive free email-alerts when new articles cite this article. Sign up at: http://jimmunol.org/alerts http://www.jimmunol.org/content/185/2/1177.full#ref-list-1 http://www.jimmunol.org/content/suppl/2010/06/21/jimmunol.100011 5.DC1 This article Information about subscribing to The JI No Triage! Fast Publication! Rapid Reviews! 30 days* Why • • • Material References Permissions Email Alerts Subscription Supplementary The Journal of Immunology The American Association of Immunologists, Inc., 1451 Rockville Pike, Suite 650, Rockville, MD 20852 Copyright © 2010 by The American Association of Immunologists, Inc. All rights reserved. Print ISSN: 0022-1767 Online ISSN: 1550-6606.
    [Show full text]
  • Autocrine IFN Signaling Inducing Profibrotic Fibroblast Responses By
    Downloaded from http://www.jimmunol.org/ by guest on September 23, 2021 Inducing is online at: average * The Journal of Immunology , 11 of which you can access for free at: 2013; 191:2956-2966; Prepublished online 16 from submission to initial decision 4 weeks from acceptance to publication August 2013; doi: 10.4049/jimmunol.1300376 http://www.jimmunol.org/content/191/6/2956 A Synthetic TLR3 Ligand Mitigates Profibrotic Fibroblast Responses by Autocrine IFN Signaling Feng Fang, Kohtaro Ooka, Xiaoyong Sun, Ruchi Shah, Swati Bhattacharyya, Jun Wei and John Varga J Immunol cites 49 articles Submit online. Every submission reviewed by practicing scientists ? is published twice each month by Receive free email-alerts when new articles cite this article. Sign up at: http://jimmunol.org/alerts http://jimmunol.org/subscription Submit copyright permission requests at: http://www.aai.org/About/Publications/JI/copyright.html http://www.jimmunol.org/content/suppl/2013/08/20/jimmunol.130037 6.DC1 This article http://www.jimmunol.org/content/191/6/2956.full#ref-list-1 Information about subscribing to The JI No Triage! Fast Publication! Rapid Reviews! 30 days* Why • • • Material References Permissions Email Alerts Subscription Supplementary The Journal of Immunology The American Association of Immunologists, Inc., 1451 Rockville Pike, Suite 650, Rockville, MD 20852 Copyright © 2013 by The American Association of Immunologists, Inc. All rights reserved. Print ISSN: 0022-1767 Online ISSN: 1550-6606. This information is current as of September 23, 2021. The Journal of Immunology A Synthetic TLR3 Ligand Mitigates Profibrotic Fibroblast Responses by Inducing Autocrine IFN Signaling Feng Fang,* Kohtaro Ooka,* Xiaoyong Sun,† Ruchi Shah,* Swati Bhattacharyya,* Jun Wei,* and John Varga* Activation of TLR3 by exogenous microbial ligands or endogenous injury-associated ligands leads to production of type I IFN.
    [Show full text]
  • P75 Neurotrophin Receptor Expression Is a Characteristic of the Mitotically Quiescent Cancer Stem Cell Population Present in Esophageal Squamous Cell Carcinoma
    INTERNATIONAL JOURNAL OF ONCOLOGY 48: 1943-1954, 2016 p75 neurotrophin receptor expression is a characteristic of the mitotically quiescent cancer stem cell population present in esophageal squamous cell carcinoma TETSUJI YAMAGUCHI1, TOMOYUKI OKUMURA1, Katsuhisa HIRANO1, TORU Watanabe1, Takuya Nagata1, Yutaka SHIMADA2 and KAZUHIRO TSUKADA1 1Department of Surgery and Science, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama City, Toyama 930-0194; 2Department of Nanobio Drug Discovery, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan Received December 8, 2015; Accepted January 11, 2016 DOI: 10.3892/ijo.2016.3432 Abstract. Mitotically quiescent cancer stem cells (CSC) are identified and isolated based on their p75NTR expression, hypothesized to exhibit a more aggressive phenotype involving providing researchers with a novel diagnostic and therapeutic greater therapeutic resistance and metastasis. The aim of our target. study was to develop a method for identifying quiescent CSC in esophageal squamous cell carcinoma (ESCC) based on Introduction their expression of the p75 neurotrophin receptor (p75NTR) and other proposed CSC markers, such as CD44 and CD90. Recent studies have demonstrated that some cancer stem Double immunostaining of surgical ESCC specimens cells (CSC) remain in a mitotically quiescent state, which revealed that the mean Ki-67-labeling index of the p75NTR- enhances their chemoresistance and results in a more inva- positive cells was significantly lower than that of the sive and aggressive phenotype (1,2). The p75 neurotrophin p75NTR-negative cells. Real-time PCR analysis of sorted receptor (p75NTR) is expressed in the quiescent basal layer of fractions of ESCC cell lines (KYSE cells) revealed that stem the esophageal epithelium (3,4), and in esophageal squamous cell-related genes (Nanog, p63 and Bmi-1) and epithelial- cell carcinoma (ESCC).
    [Show full text]
  • Breast Cancer Disparities How Can We Leverage Genomics to Improve Outcomes?
    Breast Cancer Disparities How Can We Leverage Genomics to Improve Outcomes? a b, Melissa B. Davis, PhD , Lisa A. Newman, MD, MPH * KEYWORDS Disparities Genetics Genomics African ancestry KEY POINTS Advances in breast cancer genomics will provide important insights regarding explanations for variations in incidence, as well as disparate outcomes, between African American and white American breast cancer patients. Germline genomics are essential in genetic counseling and risk assessment programs; somatic or tumor-based genomics will be critical in defining prognostic and therapeutic algorithms. It is imperative that the oncology community be prepared to apply these technologies equitably to diverse patient populations. BACKGROUND Disparities in breast cancer risk and outcome related to racial-ethnic identity in the United States have been documented by population-based statistics from the Surveil- lance, Epidemiology, and End Results (SEER) Program over the past several decades. These patterns are further supported by data from a variety of health care systems and oncology programs. Variations in the breast cancer burden of African Americans (AA) women compared with white American (WA) women have been the subject of rigorous study1 because of the magnitude of the observed differences and are the focus of this article. Table 1 summarizes these divergent patterns. Breast cancer mortality rates are higher for AA compared with WA women, and this is at least partly explained by a more advanced stage distribution, with AA women being diagnosed more frequently with larger, node-positive disease. Breast cancer incidence Disclosure: This work was partially supported by Susan G. Komen for the Cure through Komen Scholars Leadership Grant HFHS F11047 (LAN).
    [Show full text]