(12) United States Patent (10) Patent No.: US 8,012,931 B2 Cujec Et Al
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US008O12931B2 (12) United States Patent (10) Patent No.: US 8,012,931 B2 Cujec et al. (45) Date of Patent: Sep. 6, 2011 (54) MODIFIED FGF-21 POLYPEPTIDES AND 3. A g 3. colottis i etetal al. THEIR USES 4,670,417 A 6, 1987 Iwasaki et al. 4,671,958 A 6, 1987 Rodwell et al. (75) Inventors: Thomas P. Cujec, San Diego, CA (US); 4,680,338 A 7, 1987 Sundoro Roberto Mariani, San Diego, CA (US); 4,687,777 A 8/1987 Meguro et al. 4,689,406 A 8, 1987 Banks et al. isy's 4,699,784. A 10/1987 Shih et al. iego, CA (US); William reele, 4,738,921 A 4, 1988 Belagaje et al. West Hollywood, CA (US); Nick 4,755.465 A 7/1988 Gray et al. Knudsen, San Diego, CA (US); Lillian 26. A s 3. s 1 Ho, San Diego, CA (US), Jason 4,873,080 A 10/1989 Brickletray et al. al. Pinkstaff. Encinitas, CA (US), Vadim 4,873.255. A 10/1989 Yoshioka et al. Kraynov, San Diego, CA (US) 4,876, 197 A 10/1989 Burke et al 4,880,734 A 11/1989 Burke et al. 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