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Hemoglobin Switching Meeting Programs 1 – 21 Conferences (1978 – 2018)

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Hemoglobin Switching Meeting Programs 1 – 21 Conferences (1978 – 2018) HEMOGLOBIN SWITCHING MEETING PROGRAMS 1ST – 21ST CONFERENCES (1978 – 2018) George Stamatoyannopoulos 1934-2018 FIRST CONFERENCE ON HEMOGLOBIN SWITCHING PART I. DEVELOPMENTAL HEMOGLOBINS IN MAN AND ANIMAL MODELS A. Human Fetal Hemoglobin Genetics of Fetal Hemoglobin Production in Adult Life D.J. Weatherall, W.G Wood & J. B. Clegg Human Gamma Chains: Structural Features W.A. Schroder & T.H.J. Huisman The in vivo Biology of F Cells in Man S.H. Boyer & G.J. Dover On the Origin of F Cells in the Adult: Clues from Studies in Clonal Hemopathies T. Papayannopoulou & G Stamatoyannopoulos Fetal Erythropoiesis in Bone Marrow Failure Syndromes B.P. Alter Age and Sex Effects on Hemoglobin F in Sickle Cell Anemia D.L. Rucknagel, S.H. Hanash, C.F. Sing, W.P. Winter, G.F. Whitten & A.S. Prasad Hemoglobin F and Thalassemia P. Fessas Fetal Hemoglobin in Women with Hydatidiform Molar Pregnancy J.C. Lee B. Physiology of Hemoglobin Switching Stimulation of Fetal Hemoglobin Synthesis Following Stress Erythropoiesis J. De Simone, P. Heller & S.I. Biel The Sheep as an Animal Model for the Switch from Fetal to Adult Hemoglobins W.G. Wood, J. Nash, D.J. Weatherall, J.S. Robinson & F.A. Harrison Effect of Thyroid Hormone on Erythropoiesis and the Switch from Fetal to Adult Hemoglobin Synthesis in Fetal Sheep E.D. Zanjani, B.J. Gormus, A. Bhathavathsalan, T.M. Engler, A.P. McHale & L.I. Mann Stimulation of Hemoglobin C Synthesis by Erythropoietin in Fetal and Neonatal Sheep J.E. Barker, J.E. Pierce & A.W. Nienhuis C. Hemoglobins in Early Development Determination and Differentiation in Early Embryonic Erythropoiesis: A New Experimental Approach V.M. Ingram, R.W. Kean & P.C. Lindblad Regulation of Embryonic and Adult Hemoglobin Synthesis in Chickens A.J. Tobin, B.S. Chapman, D.A. Hansen, L. Lasky & S.E. Selvig Hemoglobin Ontogeny in Fetal Mice: Adult Hemoglobin in Yolk Sac Derived Erythrocytes D.H.K. Chui, T.W. Brotherton & J. Gauldie Embryonic Hemoglobins in α-Thalassemia Mice R.A. Popp, B.S. Bradshaw & G.P. Hirsch Developmental Hemoglobins in the Hamster J.F. Bertles & T. Boussios PART II. HEMOGLOBIN SWITCHING AND ERYTHROID CELL DIFFERENTIATION D. Regulation of Erythropoiesis In Vitro Characterization of Erythroid Precursor Cells and the Erythropoietic Differentiation Process C.J. Eaves, R.K. Humphries & A.C. Eaves Interactions of Hematopoietic Cells M.J. Cline & D.W. Golde The Influence of T cells on Erythropoiesis D.G. Nathan, D.G. Hillman & J. Breard Hormonal Effects on Erythroid Stem Cells D.W. Golde, N. Bersch & M.J. Cline E. Hemoglobin Switching in Culture Fetal Hemoglobin and the Erythroid Stem Cell Differentiation Process G. Stamatoyannopoulos & T. Papayannopoulou Control of Fetal Hemoglobin Synthesis in Adult Erythroid Precursor Cells: Evidence for Different Programs for Bone Marrow and Peripheral Blood Precursors D. Housman, B. Clarke, D. Hillman, B. Alter, B. Forget & D. Nathan Preferential Synthesis of Fetal Hemoglobin in Culture by Human Erythropoietic Precursors in the Marrow and Blood M. Ogawa, K. Kidoguchi & J.D. Karam Distribution of Fetal Hemoglobin in Individual Colonies by RIA: A Lead Toward Human Stem Cells H.A. Messner & A.A. Fauser Hormonal Influences on Globin Chain Synthesis of Fetal Cord Blood BFU-E in vitro R. Hoffman, N. Dainiak, E. Coupal, L. Maffei, K. Ritchey & B.G. Forget Induction of Hemoglobin C Synthesis in Sheep: Characterization of the “Switching” Stem Cell A.W. Nienhuis, R.D. Croissant & J.E. Barker F. Commitment and Biochemical Differentiation of Erythroid Cells Commitment to Differentiation of Normal and Transformed Erythroid Precursors R.A. Rifkind, E. Fibach, G. Maniatis, R. Gamari & P.A. Marks Expression of Globin Genes During Induced Erythroleukemia Cell Differentiation P.A. Marks, R.A. Rifkind, A. Bank, M. Terada, R. Gambari, E. Fibach, G. Maniatis & R. Reuben Globin Synthesis in Mouse Erythroleukemia Cells: Effect of Various Inducers B.A. Alter A Model for Differentiation: Modification of Chromatin Proteins in Differentiating Erythroid and Nonerythroid Cells V.M. Ingram, H.K. Hagopian, M.G. Riggs, J.R. Neumann, M.E. Dobson, B.B. Owens & G.M. Maniatis PART III. MOLECULAR BIOLOGY OF HEMOGLOBIN SWITCHING G. Organization of Globin Genes The Organization of Mouse β-Globin Genes P. Leder, S. Tilghman, D. Tiemeier, D. Konkel, J.G. Seidman & H.I. Miller Isolation and Characterization of Mammalian Globin Genes E. Lacy, R.M. Lawn, E. Fritsch, R.C. Hardison, R.C. Parker & T. Maniatis Organization of the Human Globin Genes in Normal and Thalassemia Cells A. Bank, J.G. Mears & F. Ramirez Restriction Mapping of Human Globin Genes in Cellular DNA: The Organization of the Duplicated Alpha Loci S.H. Orkin The Map of Human γ-Globin Genes R. Williamson H. Globin mRNA Structure Globin mRNA Structure: General Features and Sequence Homology B.G. Forget, J.T. Wilson, L.B. Wilson, C. Cavallesco, V.B. Reddy, J.K. deRiel, A.P. Biro, P.K. Ghosh & S.M. Weissman Nucleotide Sequences of the Untranslated 5’ and 3’ Regions of Human α-, β- and γ-Globin mRNAs Y.W. Kan, J.C. Chang & R. Poon 5’-Terminal Modification of Globin Messenger RNA H.H. Kazazian Jr, T. Cheng & S. Cho Analysis of Chicken Globin cDNA Clones: Discovery of a Novel Chicken Alpha-Globin Gene Induced by Stress in Young Chickens W.A. Salser, I. Cummings, A. Liu, J. Strommer, J. Padayatty & P. Clarke I. Metabolism of Globin mRNA The Structure and Metabolism of the Precursors of Mouse α- and β-globin mRNAs J Ross, A.J. Kinniburgh & J.E. Mertz Processing and Turnover of Globin mRNA During Erythroid Maturation J.B. Lingrel, K. Lowenhaupt, J.R. Haynes, P. Rosteck Jr., V.F. Kalb Jr. & K. Smith Regulation of Embryonic Hemoglobin in Chickens L-N.L. Chan Regulation of the Individual Globin mRNAs During Hemoglobin Switching in Sheep E.J. Benz Jr., J.A. Kantor & A.W. Nienhuis J. Control of Globin Gene Expression Control of Globin Gene Expression H. Weintraub, M. Groudine, S. Weisbrod, D. Riley & I. Albanese Structure of the Individual Globin Genes in Chromatin N.S. Young, E.J. Benz Jr. & A. Nienhuis Study of Expression of Human Globin Genes in Hybrid Mouse Erythroleukemia Cells A. Deisseroth & D. Hendrick A New Approach in the Search for Globin Gene Regulatory Factors W.F. Anderson, M.C. Willing, D.E. Axelrod, T.V. Gopalakrishnan & E.G. Diacumakos The1st Hemoglobin Switching Meeting Battelle Institute Seattle: 1978 This conference was a small gathering (75 participants) of physicians, cell biologists, and molecular biologists . The program covered the whole field of hemoglobin switching as of 1978.. Erythropoiesis Structure of Globin Genes (mainly Southern Blotting) Chromatin Structure Hb Switching Cell, Vol . 15, 307-315, September 1978, Copyright © 1978 by MIT Hemoglobin Switching Meeting Review Arthur W . Nienhuis of Hb F (14-28% of total) and 24-27 pg of Hb A Clinical Hematology Branch (Boyer ; Johns Hopkins) ; 0 .2-7% of the red cells in National Heart, Lung and Blood Institute normal humans are F cells . In various heterocellu- Bethesda, Maryland 20014 lar HPFH syndromes (genetic states characterized George Stamatoyannopoulos by increased Hb F production in the absence of Medical Genetics other changes in the red cell) the number of F cells University of Washington is increased . Linkage analysis (Weatherall ; Oxford) Seattle, Washington 98195 appears to suggest that the gene for heterocellular HPFH is linked to the human y-5-/3 gene complex Introduction known to be on chromosone 11 (Deisseroth ; NIH) . In the Saudi Arabian population of patients with On June 19-21, 1978, a conference was held to sickle cell anemia, clinical manifestations are very review the current state of knowledge on the mech- mild and Hb F comprises 20-40% of the total anism of regulation of hemoglobin switching . The hemoglobin . Heterozygotes for the /3 gene in this transitions from embryonic to fetal (or adult) he- population have little increase in Hb F, excluding moglobin synthesis occurring early in embryogen- heterocellular HPFH as the basis for increased Hb esis and the transition from fetal to adult produc- F production in the SS individuals . The anemic tion at about the time of birth in several species stress due to sickle cell anemia brings out a pro- were discussed . These switches represent models pensity for Hb F production in this genetic isolate, in which one can examine the regulation of individ- in contrast to the much smaller amounts of Hb F ual globin genes both at the molecular level and seen in most black patients with SS disease . In during the various stages of cellular differentiation patients with homozygous /3 thalassemia, red cell that lead to production of red blood cells contain- production may be increased more than 25 fold . ing particular hemoglobins . The ability to stimulate The increase in Hb F may be accounted for by fetal hemoglobin (Hb F) production in adults might simple amplification of the F cell population, since be of therapeutic benefit in patients with sickle cell those cells containing Hb F have a selective advan- anemia or severe variants of homozygous /3 thal- tage both during erythropoiesis in the bone marrow assemia . In addition, certain mutations in humans and circulation of red cells in the blood stream . are characterized by enhanced production of Hb F . Thus a consideration of the various genetic con- Thus at this conference an effort was made to ditions which lead to increased Hb F production in examine the known clinical, genetic and experi- adults identifies several potential mechanisms: mental observations directly pertinent to various gene deletion, mutations in a regulatory locus developmental or physiological switches in hemo- linked to the y-5-/3 globin gene complex, activation globin phenotype, and to relate these data to re- of a latent potential for Hb F production by anemia, cent developments in cellular and molecular biol- or amplification of the normal F cell population by ogy, in an effort to develop a framework for the severe erythropoietic stress .
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