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IMMUNOLOGYwww.jimmunol.org Volume 176 / No. 6 / March 15, 2006 OF OURNAL J THE IMMUNOLOGYProgram Issue2006 Co-sponsored by Sir Philip Cohen and Professor Dario Alessi of the MRC Protein Phosphorylation Unit, and Professor Doreen Cantrell, University of Dundee Symposium Location: Apex City Quay Hotel & Spa, Dundee, UK tel +44 (0) 1382 561600 AN INITIATIVE TO RECOGNISE & REWARD OUTSTANDING RESEARCH WITHIN THE CELL SIGNALLING AREA Submission Deadline: 31st March, 2006 The successful young scientist will receive reagents and support funding of £10,000/$17,000/€14,000 donated to their laboratory, a personal cash prize of £5,000/$8,500/€7,000, plus a trophy. IMMUNOLOGY 2006 Annual Meeting of The American Association of Immunologists May 12–16, 2006 Hynes Convention Center • Boston, MA ImportantImportant DeadlinesDeadlines EARLY REGISTRATION HOTEL RESERVATIONS VISA INFORMATION March 6, 2006 April 13, 2006 www.aai.org/Imm2006/TransVisas.htm For complete meeting information visit www.aai.org/Imm2006/default.htm AAI Program PRESIDENT’S PROGRAM President’s Symposium DISTINGUISHED LECTURES T Cell Recognition and Development President’s Address Supported through an unrestricted educa- Defining Yourself: Tolerance Development Monday, May 15, 2:30 PM tional grant from Genentech, Inc. Hynes Convention Center, Ballroom A/B in the Immune System Ronald N. Germain, NIAID, NIH Chair: Paul M. Allen, Washington Univ. Saturday, May 13, 5:00 PM Friday, May 12, 5:00 PM School of Medicine, AAI President Hynes Convention Center, Ballroom A/B Hynes Convention Center, Ballroom A/B Speakers Introduction: Emil R. Unanue A reconstructionist's view Philippa Marrack, HHMI, Washington Univ. School of Medicine of antigen-specific T cell National Jewish Med. and Res. activation: from molecules Speaker: Paul M. Allen Ctr., T cell receptors and MHC to models to movies Washington Univ. School of Medicine, AAI President Arlene Sharpe, Harvard Medical School Mark M. Davis, HHMI, Sunday, May 14, 5:00 PM Stanford Univ., Safety in num- Hynes Convention Center, Ballroom A/B bers: quantitating T cell respon- Presentation The B7/CD28 family: siveness at different stages of moderating T cell activation AAI Lifetime Achievement Award differentiation and the role of and tolerance Monday, May 15, 2:30 PM endogenous peptides Hynes Convention Center, Ballroom A/B Michael J. Bevan, HHMI, Univ. Introduction & Presentation: Paul M. Allen, of Washington, Maintaining Washington Univ. School of Medicine, the CD8+ T cell response Christopher C. Goodnow, The Australian AAI President National Univ. Award Recipient: Hugh O. Monday, May 15, 5:00 PM McDevitt, Stanford Univ. Hynes Convention Center, Ballroom A/B School of Medicine – Andrey S. Shaw, Washington In recognition of distin- Univ. School of Medicine, Mechanisms and genes guished scientific accomplish- Structure and function of the inhibiting autoimmunity: ment and extraordinary immunological synapse many moving parts prone service to the AAI to failure Major Symposia Saturday, May 13, 8:00 AM Astar Winoto, Univ. of California, Berkeley, Akiko Iwasaki, Yale Univ., Initiation of T cell apoptosis and proliferation: are they antiviral mucosal immunity Major Symposium A: linked? Madhav Dhodapkar, The Rockefeller Univ., Cell Death and the Immune System Ralph C. Budd, Univ. of Vermont College of Linking innate and adaptive immunity Hynes Convention Center, Ballroom C Medicine, Caspases in T cell activation: via dendritic cells the FLIP side Gwendalyn Randolph, Mount Sinai School Chair: Barbara A. Osborne, Univ. of of Medicine, Dendritic cell migration to Massachusetts Major Symposium B: lymph nodes Co-Chair: Jonathan D. Ashwell, NCI, NIH Marika Sarfati, Univ. of Montreal, Negative Dendritic Cells regulation of dendritic cell function by the Speakers Hynes Convention Center, Ballroom A/B Barbara A. Osborne, Univ. of Massachusetts, CD47/thrombospondin/SIRP-alpha axis Nur77-mediated cell death: is location Chair: Marco Colonna, Washington Univ. important? School of Medicine Sunday, May 14, 8:00 AM Jonathan D. Ashwell, NCI, NIH, Co-Chair: Jacques Banchereau, Baylor Inst. for Immunology Research Major Symposium C: Multifaceted role of ubiquitin in pro- and Innate and Adaptive Recognition of Bacteria anti-apoptotic signaling pathways Speakers Supported through an unrestricted educa- Kodi Ravichandran, Univ. of Virginia, Marco Colonna, Washington Univ. School of tional grant from Gemini Science, Inc. Engulfment of apoptotic cells: the begin- Medicine, Plasmacytoid dendritic cells in nings of a good meal immunity Hynes Convention Center, Ballroom A/B Richard Siegel, NIAMS, NIH, Life and death Jacques Banchereau, Baylor Inst. for Chair: Mitchell Kronenberg, La Jolla Inst. decisions on the road to T cell differentia- Immunology Research, Pathophysiology for Allergy and Immunology Co-Chair: Eric Pamer, Memorial Sloan- tion and memory of dendritic cell subsets Kettering Cancer Center Special Symposia Barton F. Haynes, Duke Univ. Medical Award Lectures NIH Institutes Sponsored Symposia Center AAI-Dana Foundation Award in Human National Institute of Allergy and Infectious Michel C. Nussenzweig, HHMI, The Rockefeller Univ. Immunology Research: Presentation & Diseases (NIAID) Lecture Joseph Sodroski, Dana-Farber Cancer Supported through an unrestricted educa- • Contemporary Topics in Immunology Inst. tional grant from the Dana Foundation Friday, May 12, 2:45 PM, Michael McHeyzer-Williams, Scripps Hynes Convention Center, Rm. 302 Research Inst. Susan Zolla-Pazner, New York Univ. Saturday, May 13, 3:15 PM, Chair: Alison Deckhut Augustine, NIAID, Hynes Convention Center, Ballroom C NIH School of Medicine Chair: Paul M. Allen, Washington Univ. Co-Chair: Leslie J. Berg, Univ. of School of Medicine, AAI President Massachusetts Medical Center, AAI National Cancer Institute (NCI) Introduction: Michel Nussenzweig Program Chair • Immunoregulation in Tumor (representing the Dana Foundation), Speakers The Rockefeller Univ. Microenvironments: A Therapeutic Target Rosemarie DeKruyff, Children's Hospital Monday, May 15, 9:45 AM, Award Recipient: Max D. Boston, Harvard Medical School, The Hynes Convention Center, Rm. 302 Cooper, HHMI, Univ. of TIM gene family: regulating allergy and Chair: Richard B. Bankert, SUNY, Buffalo Alabama at Birmingham, tolerance Co-Chair: Susan A. McCarthy, NCI, NIH An evolutionary approach to Russell Salter, Univ. of Pittsburgh, human immunological Communication between immune cells Speakers diseases mediated by membrane nanotubules John Niederhuber, Deputy Director, NCI, Thomas B. Kepler, Duke Univ., NIH, Immunotherapy directed to tumor AAI-BD Biosciences Investigator Computational approaches to cellular and its microenvironment Award & Lecture reorganization in the immune response Weiping Zou, Tulane Univ. School of Supported through an unrestricted educa- John T. Harty, Carver College of Medicine, Medicine, Controlling T cells in the tional grant from BD Biosciences Univ. of Iowa, Accelerating CD8+T cell tumor microenvironment memory Lori Broderick, SUNY at Buffalo School of Sunday, May 14, 2:30 PM, Medicine, IL-12/TGF-ß1 regulation of Hynes Convention Center, Ballroom A/B • The Humanized Mouse: TCR signal transduction in human lung Chair: Paul M. Allen, Washington Univ. Past, Present, and Future tumor-associated memory T cells School of Medicine, AAI President Saturday, May 13, 10:15 AM, Hans Schreiber, Univ. of Chicago, Co-Chair: J. "Kip" Miller, Vice Hynes Convention Center, Rm. 302 Immunological destruction of the President/General Manager, BD Biosciences Chair: Francesca Macchiarini, NIAID, NIH tumor microenvironment Award Recipient: Ruslan Co-Chair: Leonard D. Shultz, The Jackson Francesco M. Marincola, NIH, Human Medzhitov, HHMI-Yale Univ. Laboratory tumor host interactions at the receiving end: the tumor microenvironment School of Medicine, Innate Speakers immune recognition: Leonard D. Shultz, The Jackson mechanisms and pathways Laboratory, Humanized SCID mice: National Institute on Aging (NIA) a long road traveled Dale Greiner, Univ. of Massachusetts • How Aging Impacts Immunity AAI-Huang Foundation Meritorious Medical School, Immunity in human- Saturday, May 13, 1:30 PM, Career Award & Lecture ized SCID mice Hynes Convention Center, Rm. 304 Supported through an unrestricted educa- Karolina Palucka, Baylor Inst. for Chair: Susan Swain, Trudeau Inst., AAI tional grant from the Huang Foundation Immunology Research, OncoHumouse Past President to identify how cancers subvert human Co-Chair: Laura Haynes, Trudeau Inst. immune responses Sunday, May 14, 3:30 PM, Speakers Markus Manz, Inst. for Research in Hynes Convention Center, Ballroom A/B Richard J. Hodes, Director, NIA, NIH, Biomedicine, Bellinzona, Switzerland, Chair: Paul M. Allen, Washington Univ. Welcome and introduction huAIS-RG mice - new options to study School of Medicine, AAI President Kenneth A. Dorshkind, UCLA School of human lymphotropic infections in vivo? Co-Chair: Ernest C-M Huang, President, Medicine, Effects of aging on develop- Huang Foundation • Bewitched, Bothered, and Bewildered: ment of the innate and adaptive Award Recipient: Laurie H. Strategies for Engineering B Cell immune system Graham Pawelec, Tübingen Aging and Glimcher, Harvard School of Reactivity in HIV Vaccination Workshop Public Health and Medicine, Tumour Immunology (TATI) Group, T-bet and Type 1 immunity Sunday, May 14, 10:15 AM, Medizinische Universitätsklinik und Hynes Convention Center, Rm. 304 Poliklinik, Tübingen, Germany, The Chair: Helen Quill, NIAID, NIH immune risk profile in the