IMMUNOLOGYwww.jimmunol.org Volume 176 / No. 6 / March 15, 2006 OF OURNAL J THE

IMMUNOLOGYProgram Issue2006 Co-sponsored by Sir Philip Cohen and Professor Dario Alessi of the MRC Protein Phosphorylation Unit, and Professor Doreen Cantrell, University of Dundee

Symposium Location: Apex City Quay Hotel & Spa, Dundee, UK

tel +44 (0) 1382 561600

AN INITIATIVE TO RECOGNISE & REWARD OUTSTANDING RESEARCH WITHIN THE CELL SIGNALLING AREA

Submission Deadline: 31st March, 2006

The successful young scientist will receive reagents and support funding of £10,000/$17,000/€14,000 donated to their laboratory, a personal cash prize of £5,000/$8,500/€7,000, plus a trophy. IMMUNOLOGY 2006

Annual Meeting of The American Association of Immunologists May 12–16, 2006 Hynes Convention Center • Boston, MA

ImportantImportant DeadlinesDeadlines

EARLY REGISTRATION HOTEL RESERVATIONS VISA INFORMATION March 6, 2006 April 13, 2006 www.aai.org/Imm2006/TransVisas.htm

For complete meeting information visit www.aai.org/Imm2006/default.htm AAI Program

PRESIDENT’S PROGRAM President’s Symposium DISTINGUISHED LECTURES T Cell Recognition and Development President’s Address Supported through an unrestricted educa- Defining Yourself: Tolerance Development Monday, May 15, 2:30 PM tional grant from Genentech, Inc. Hynes Convention Center, Ballroom A/B in the Immune System Ronald N. Germain, NIAID, NIH Chair: Paul M. Allen, Washington Univ. Saturday, May 13, 5:00 PM Friday, May 12, 5:00 PM School of Medicine, AAI President Hynes Convention Center, Ballroom A/B Hynes Convention Center, Ballroom A/B Speakers Introduction: Emil R. Unanue A reconstructionist's view Philippa Marrack, HHMI, Washington Univ. School of Medicine of antigen-specific T cell National Jewish Med. and Res. activation: from molecules Speaker: Paul M. Allen Ctr., T cell receptors and MHC to models to movies Washington Univ. School of Medicine, AAI President

Arlene Sharpe, Harvard Medical School Mark M. Davis, HHMI, Sunday, May 14, 5:00 PM Stanford Univ., Safety in num- Hynes Convention Center, Ballroom A/B bers: quantitating T cell respon- Presentation The B7/CD28 family: siveness at different stages of moderating T cell activation AAI Lifetime Achievement Award differentiation and the role of and tolerance Monday, May 15, 2:30 PM endogenous peptides Hynes Convention Center, Ballroom A/B Michael J. Bevan, HHMI, Univ. Introduction & Presentation: Paul M. Allen, of Washington, Maintaining Washington Univ. School of Medicine, the CD8+ T cell response Christopher C. Goodnow, The Australian AAI President National Univ. Award Recipient: Hugh O. Monday, May 15, 5:00 PM McDevitt, Stanford Univ. Hynes Convention Center, Ballroom A/B School of Medicine – Andrey S. Shaw, Washington In recognition of distin- Univ. School of Medicine, Mechanisms and genes guished scientific accomplish- Structure and function of the inhibiting autoimmunity: ment and extraordinary immunological synapse many moving parts prone service to the AAI to failure

Major Symposia

Saturday, May 13, 8:00 AM Astar Winoto, Univ. of California, Berkeley, Akiko Iwasaki, Yale Univ., Initiation of T cell apoptosis and proliferation: are they antiviral mucosal immunity Major Symposium A: linked? Madhav Dhodapkar, The Rockefeller Univ., Cell Death and the Immune System Ralph C. Budd, Univ. of Vermont College of Linking innate and adaptive immunity Hynes Convention Center, Ballroom C Medicine, Caspases in T cell activation: via dendritic cells the FLIP side Gwendalyn Randolph, Mount Sinai School Chair: Barbara A. Osborne, Univ. of of Medicine, Dendritic cell migration to Massachusetts Major Symposium B: lymph nodes Co-Chair: Jonathan D. Ashwell, NCI, NIH Marika Sarfati, Univ. of Montreal, Negative Dendritic Cells regulation of dendritic cell function by the Speakers Hynes Convention Center, Ballroom A/B Barbara A. Osborne, Univ. of Massachusetts, CD47/thrombospondin/SIRP-alpha axis Nur77-mediated cell death: is location Chair: Marco Colonna, Washington Univ. important? School of Medicine Sunday, May 14, 8:00 AM Jonathan D. Ashwell, NCI, NIH, Co-Chair: Jacques Banchereau, Baylor Inst. for Immunology Research Major Symposium C: Multifaceted role of ubiquitin in pro- and Innate and Adaptive Recognition of Bacteria anti-apoptotic signaling pathways Speakers Supported through an unrestricted educa- Kodi Ravichandran, Univ. of Virginia, Marco Colonna, Washington Univ. School of tional grant from Gemini Science, Inc. Engulfment of apoptotic cells: the begin- Medicine, Plasmacytoid dendritic cells in nings of a good meal immunity Hynes Convention Center, Ballroom A/B Richard Siegel, NIAMS, NIH, Life and death Jacques Banchereau, Baylor Inst. for Chair: Mitchell Kronenberg, La Jolla Inst. decisions on the road to T cell differentia- Immunology Research, Pathophysiology for Allergy and Immunology Co-Chair: Eric Pamer, Memorial Sloan- tion and memory of dendritic cell subsets Kettering Cancer Center Special Symposia

Barton F. Haynes, Duke Univ. Medical Award Lectures NIH Institutes Sponsored Symposia Center AAI-Dana Foundation Award in Human National Institute of Allergy and Infectious Michel C. Nussenzweig, HHMI, The Rockefeller Univ. Immunology Research: Presentation & Diseases (NIAID) Lecture Joseph Sodroski, Dana-Farber Cancer Supported through an unrestricted educa- • Contemporary Topics in Immunology Inst. tional grant from the Dana Foundation Friday, May 12, 2:45 PM, Michael McHeyzer-Williams, Scripps Hynes Convention Center, Rm. 302 Research Inst. Susan Zolla-Pazner, New York Univ. Saturday, May 13, 3:15 PM, Chair: Alison Deckhut Augustine, NIAID, Hynes Convention Center, Ballroom C NIH School of Medicine Chair: Paul M. Allen, Washington Univ. Co-Chair: Leslie J. Berg, Univ. of School of Medicine, AAI President Massachusetts Medical Center, AAI National Cancer Institute (NCI) Introduction: Michel Nussenzweig Program Chair • Immunoregulation in Tumor (representing the Dana Foundation), Speakers The Rockefeller Univ. Microenvironments: A Therapeutic Target Rosemarie DeKruyff, Children's Hospital Monday, May 15, 9:45 AM, Award Recipient: Max D. Boston, Harvard Medical School, The Hynes Convention Center, Rm. 302 Cooper, HHMI, Univ. of TIM gene family: regulating allergy and Chair: Richard B. Bankert, SUNY, Buffalo Alabama at Birmingham, tolerance Co-Chair: Susan A. McCarthy, NCI, NIH An evolutionary approach to Russell Salter, Univ. of Pittsburgh, human immunological Communication between immune cells Speakers diseases mediated by membrane nanotubules John Niederhuber, Deputy Director, NCI, Thomas B. Kepler, Duke Univ., NIH, Immunotherapy directed to tumor AAI-BD Biosciences Investigator Computational approaches to cellular and its microenvironment Award & Lecture reorganization in the immune response Weiping Zou, Tulane Univ. School of Supported through an unrestricted educa- John T. Harty, Carver College of Medicine, Medicine, Controlling T cells in the tional grant from BD Biosciences Univ. of Iowa, Accelerating CD8+T cell tumor microenvironment memory Lori Broderick, SUNY at Buffalo School of Sunday, May 14, 2:30 PM, Medicine, IL-12/TGF-ß1 regulation of Hynes Convention Center, Ballroom A/B • The Humanized Mouse: TCR signal transduction in human lung Chair: Paul M. Allen, Washington Univ. Past, Present, and Future tumor-associated memory T cells School of Medicine, AAI President Saturday, May 13, 10:15 AM, Hans Schreiber, Univ. of Chicago, Co-Chair: J. "Kip" Miller, Vice Hynes Convention Center, Rm. 302 Immunological destruction of the President/General Manager, BD Biosciences Chair: Francesca Macchiarini, NIAID, NIH tumor microenvironment Award Recipient: Ruslan Co-Chair: Leonard D. Shultz, The Jackson Francesco M. Marincola, NIH, Human Medzhitov, HHMI-Yale Univ. Laboratory tumor host interactions at the receiving end: the tumor microenvironment School of Medicine, Innate Speakers immune recognition: Leonard D. Shultz, The Jackson mechanisms and pathways Laboratory, Humanized SCID mice: National Institute on Aging (NIA) a long road traveled Dale Greiner, Univ. of Massachusetts • How Aging Impacts Immunity AAI-Huang Foundation Meritorious Medical School, Immunity in human- Saturday, May 13, 1:30 PM, Career Award & Lecture ized SCID mice Hynes Convention Center, Rm. 304 Supported through an unrestricted educa- Karolina Palucka, Baylor Inst. for Chair: Susan Swain, Trudeau Inst., AAI tional grant from the Huang Foundation Immunology Research, OncoHumouse Past President to identify how cancers subvert human Co-Chair: Laura Haynes, Trudeau Inst. immune responses Sunday, May 14, 3:30 PM, Speakers Markus Manz, Inst. for Research in Hynes Convention Center, Ballroom A/B Richard J. Hodes, Director, NIA, NIH, Biomedicine, Bellinzona, Switzerland, Chair: Paul M. Allen, Washington Univ. Welcome and introduction huAIS-RG mice - new options to study School of Medicine, AAI President Kenneth A. Dorshkind, UCLA School of human lymphotropic infections in vivo? Co-Chair: Ernest C-M Huang, President, Medicine, Effects of aging on develop- Huang Foundation • Bewitched, Bothered, and Bewildered: ment of the innate and adaptive Award Recipient: Laurie H. Strategies for Engineering B Cell immune system Graham Pawelec, Tübingen Aging and Glimcher, Harvard School of Reactivity in HIV Vaccination Workshop Public Health and Medicine, Tumour Immunology (TATI) Group, T-bet and Type 1 immunity Sunday, May 14, 10:15 AM, Medizinische Universitätsklinik und Hynes Convention Center, Rm. 304 Poliklinik, Tübingen, Germany, The Chair: Helen Quill, NIAID, NIH immune risk profile in the very elderly Co-Chair: Tony Conley, NIAID, NIH Laura Haynes, Trudeau Inst., Panelists Enhancement of the cognate helper Christopher Goodnow, John Curtin activity of aged CD4 T cells School of Medical Research, Australian Susan Swain, Trudeau Inst., Genesis of National Univ. the CD4 T cell aging defect Special Symposia, continued

Janko Nikolich-Zugich, Oregon Health Sunday, May 14, 11:00 AM, issue/option. Attendance is limited to the first Sciences Univ., Impact of persistent Hynes Convention Center, Rm. 302 350 registrants (students, postdocs, faculty, pathogens and of homeostatic forces Introduction: Ellen Kraig, Chair, AAI and staff). Men are encouraged to participate. upon the aging T cell compartment Committee on Public Affairs Roundtable topics include: Presentation: Paul M. Allen, AAI President GENERAL – Topics related to the environ- Awardees: Vicki and Fred Modell, Co- ment you work in or want to work in: Founders, The Jeffrey Modell Foundation AAI Committee Sponsored 1. Academic research: general Symposia & Sessions Pandemics and Bioterrorism: Why 2. Biotech and Industry: general Immunology Research May Save the World 3. Governmental agencies: CDC/FDA/NIH Chair: Ellen Kraig, Univ. of Texas Health 4. Clinic: Clinical and diagnostic immunol- AAI Clinical Immunology Committee Science Ctr. ogy, clinician-scientist A Global Perspective on Tuberculosis: Sunday, May 14, 12:30 PM, 5. Undergraduate Institutions: teaching, doing research part-time Prospects for Vaccines and Treatments Hynes Convention Center, Rm. 311 Friday, May 12, 2:45 PM, Speakers TRANSITIONS – Topics focused on a specific Hynes Convention Center, Rm. 304 Anthony S. Fauci, Director, NIAID, NIH, career stage: Biodefense and pandemic prepredness: Chair: Robert Seder, NIAID, Vaccine 6. Graduate student to Post-doc: finding a the research agenda Research Center post doc, interviewing Jacqueline M. Katz, Immunology and Viral Co-Chair: Joel Ernst, New York Univ. School 7. Post-doc to PI: finding a position, inter- Pathogenesis Section, Influenza Branch, of Medicine viewing, negotiating, lab start-up Centers for Disease Control and Speakers Prevention, Immunity to avian influenza 8. New PI: attracting students and post- Richard Chaisson, Johns Hopkins Bloomberg viruses: implications for pandemic pre- docs, preparing for tenure School of Public Health, How can new paredness 9. Mid-career: developing administrative technologies for TB control be translated Peter Palese, Mount Sinai School of and management skills/sabbaticals into progress on the ground? Medicine, What can we learn from recon- 10. Changing careers: moving from academia Eric Rubin, Harvard School of Public Health, structing the extinct 1918 pandemic to industry, or vice versa Protein secretion and virulence in influenza virus? Mycobacterium tuberculosis SPECIAL – Topics for unique situations: David G. Russell, Cornell University, The 11. Career and Family: time management/ host-pathogen discourse in tuberculosis AAI Committee on the Status of Women family leave/professional couples Joel Ernst, New York Univ. School of 12. Integrity and Ethics: dealing with contro- Medicine, Immune evasion by Managing Your Lab Workshop versy, discrimination in the workplace Mycobacterium tuberculosis: implications Friday, May 12, 2:45 PM, 13. Alternative careers: science journalism, for vaccine development and evaluation Hynes Convention Center, Rm. 313 patent law Chair: Laura Haynes, Trudeau Inst. 14. Politics of Science Stem Cells: The Realities, Usefulness, and Speakers 15. Networking that Immunologists Should Know Suzanne Pfeffer, Stanford Univ. School of Saturday, May 13, 12:30 PM, Medicine, Getting the best from your lab AAI Education Committee Hynes Convention Center, Rm. 302 personnel and giving them what they need Chair: Terri M. Laufer, Univ. of Pennsylvania Jeremy M. Boss, Emory Univ. School of John H. Wallace High School Teachers Co-Chair: Kathleen E. Sullivan, Children's Medicine, Achieving goals: negotiation and Workshop: Lessons in Immunology Hospital of Philadelphia management skills in science Supported through NIH Grant R25 Panelists AI 43872 Speakers Vijay K. Kuchroo, Harvard Medical School Saturday, May 13, 9:00 AM, Laurie Zoloth, Northwestern University, Why Paula Kavathas, Yale Univ. School of is bioethics like immunology? The rules of Hynes Convention Center, Rm. 309 Medicine self and other in ethical research Chair: Arthur Tzianabos, Harvard Medical Suzanne Pfeffer, Stanford Univ. School of School George Daley, Dana-Farber Cancer Institute, Medicine Embryonic stem cells in research and Presenters Jeremy M. Boss, Emory Univ. School of medicine Felicia A. Benson, Osborn High School, Medicine Ihor Lemischka, Princeton University, Detroit, MI Exploring cell fate regulation in stem cells Mentor: Yi-Chi M. Kong, Wayne State Univ. Kevin Eggan, , Careers Roundtable School of Medicine Interrogating development and disease by (Ticketed event, lunch served, registration Amanda Dice, Baltimore Talent Development nuclear transplantation required) High Sch., Baltimore, MD Monday, May 15, 12:00 PM, Mentor: Jan L. Powell, Univ. of Maryland Hynes Convention Center, Rm. 312 School of Medicine AAI Committee on Public Affairs Chair: Lori R. Covey, Rutgers Univ. Claire L. Hypolite, Edison High Sch., Minneapolis, MN Experienced scientists will serve as discussion 2006 Public Service Award Presentation Mentor: Kristin A. Hogquist, Univ. of leaders at each roundtable. They will lead Minnesota and Reception informal discussions on a specific career Special Symposia, continued

Marjorie Maxey, Western Albermarle High AAI Publications Committee Sch., Crozet, VA Invited Guest Symposia Mentor: Robert G. Sawyer, Univ. of Virginia How to Publish a Scientific Paper: AAI is joined annually by a variety of guest Tamica A. Stubbs, E.E. Waddell High Sch., Prose and Cons societies presenting two-hour symposia in Charlotte, NC Saturday, May 13, 12:30 PM, special disciplines. Invited guest societies Mentor: Juan Anguita, Univ. of North Hynes Convention Center, Rm. 208 for 2006 will present the following sessions: Carolina, Charlotte Chair: Judy Teale, Univ. of Texas Health Elizabeth Zdrojewski, West Allis West The Association of Medical Laboratory Milwaukee Sch., West Allis, WI Science Center Immunologists (AMLI) Symposium: Novel Mentor: Douglas A. Steeber, Univ. of Panelists Wisconsin Judith A. Swan, Assistant Director of Scien- Biomarker Strategies for Evaluating and tific Writing, Princeton Univ., Effective Monitoring Immunologic Diseases Survival Skills for the New PI: scientific writing from the reader's Sunday, May 14, 2:45 PM, Four Perspectives perspective Hynes Convention Center, Rm. 306 Monday, May 15, 10:15 AM, Robert R. Rich, Univ. of Alabama, Chair: Barbara Detrick, Johns Hopkins Univ. Hynes Convention Center, Rm. 208 Birmingham, School of Medicine, Editor- School of Medicine in-Chief, The Journal of Immunology, Co-Chair: Ronald J. Harbeck, National Chair: Christopher A. Pennell, The Cancer Authors, reviewers, and editors: the give Center, Univ. of Minnesota Jewish Medical and Research Center, and take relationship Univ. of Health Sciences Center Speakers Jeffrey A. Frelinger, Univ. of North Carolina, Christopher A. Pennell, The Cancer Center, Deputy Editor, The Journal of Immunol- Speakers Univ. of Minnesota ogy, How good data goes bad: things peo- Mark Duncan, Univ. of Colorado Health Andrea Sant, Univ. of Rochester ple do to not get their best work published! Sciences Center, New tools of laboratory Robert Rickert, The Burnham Inst. Linda J. Miller, U.S. Executive Editor, medicine - molecular and cellular Olivera J. Finn, Univ. of Pittsburgh Nature and the Nature research journals, proteomics - biomarkers of disease Scientific journals, plagiarism and fraud Paul J. Utz, Stanford Univ. School of Overview of Patent Law Basics Medicine, Application of proteomic Saturday, May 13, 10:15 AM, AAI VETERINARY IMMUNOLOGY technologies to autoimmune disease Scott D. Patterson, Amgen Inc., Role of Hynes Convention Center, Rm. 310 COMMITTEE and the AMERICAN proteomics in early drug development for Chair: Laurie Hill, Attorney-at-Law ASSOCIATION OF VETERINARY immune mediated diseases IMMUNOLOGISTS (AAVI) Ronald J. Harbeck, National Jewish Medical AAI Minority Affairs Committee and Research Center, Univ. of Colorado The Comparative Biology of Gamma-Delta Health Sciences Center, Proteomics in AAI Minority Affairs Committee Breakfast T Cells Symposium asthma and allergy Workshop: Networking 101 Sunday, May 14, 10:15 AM, Funded in part through a grant from the American Society of Transplantation Hynes Convention Center, Rm. 208 (AST) Symposium: B-Cells in Organ National Inst. of General Medical Sciences, Chair: William T. Golde, Foreign Animal Transplantation: Humoral Immunity as a NIH to the FASEB MARC Program T36- Disease Unit, Plum Island Animal Disease GM08059-23 Center, USDA Growing Unsolved Problem in Clinical Sunday, May 14, 8:30 AM, Co-Chair: Lorraine M. Sordillo, Michigan Transplantation Hynes Convention Center, Rm. 306 State Univ. Monday, May 15, 9:30 AM, Presenters Speakers Hynes Convention Center, Rm. 311 Avery August, Penn State Univ. Mark Jutila, Montana State Univ., Global Chair: Allan D. Kirk, NIDDK, NIH Randy R. Brutkiewicz, Indiana Univ. School gene expression analysis in gamma-delta of Medicine Speakers T cell subsets: insights into innate cell Allan D. Kirk, NIDDK, NIH, Welcome function remarks AAI Minority Affairs Committee Guest Rebecca L. O'Brien, National Jewish Medical Lecture William "Wink" Baldwin, Johns Hopkins and Research Center, and Univ. of Colorado Hospital, B-cell responses in transplan- Funded in part through a grant from the Health Sciences Center, Ligands for the tation National Inst. of General Medical Sciences, gamma-delta T cell receptor: the central Jeffrey L. Platt, Mayo Clinic, Rochester, NIH to the FASEB MARC Program T36- question Accommodation GM08059-23 Wolfgang Holtmeier, Johann Wolfgang Anita S. Chong, Univ. of Chicago, Allo Sunday, May 14, 10:30 AM, Goethe Univ., Frankfurt, Germany, specific B-cell tolerance Hynes Convention Center, Rm. 306 Comparmentalization and distribution of Megan Sykes, Massachusetts General Chair: Randy R. Brutkiewicz, Indiana Univ. porcine gamma-delta T cells: a repertoire Hospital, Tolerance to carbohydrate School of Medicine point of view antigens and xenotransplantation Guest Speaker: Diana M. Lopez, Univ. of Simon Carding, Univ. of Leeds, West Lori J. West, Univ. of Toronto, Neonatal Miami, A unique mucin immunoenhanc- Yorkshire, UK, Gamma-delta T cells in transplant tolerance: merging basic ing peptide with anti-tumor properties infection: beneficial or deleterious? immunology and clinical practice Special Symposia, continued

Canadian Society for Immunology (CSI) receptor recognition in multiple sclerosis Speakers Symposium: Cancer and the Immune Roy Mariuzza, Univ. of Maryland, André Veillette, Laboratory of Molecular Response Structural basis for self-peptide/MHC Oncology, Clinical Research Inst. of recognition by autoimmune T cell Montreal, Regulation of NK cell functions Saturday, May 13, 10:15 AM, receptors by SAP family adaptors Hynes Convention Center, Rm. 311 Joan Goverman, Univ. of Washington, T cell Kerry Campbell, Fox Chase Cancer Center, Chair: Christopher Paige, Ontario Cancer determinants of neuroinflammation Impacts of the signaling adaptor protein, Inst., Univ. Health Network Scott Zamvil, UCSF, Antigen presentation BCAP, on murine NK cell development Co-Chair: Pamela Ohashi, Campbell Family and immunomodulation in EAE and function Inst., Ontario Cancer Inst Katherine McLaughlin, Dana-Farber Cancer Daniel McVicar, Laboratory of Experimental Speakers Inst., Harvard Medical School, Myelin Immunology, NCI-Frederick, Parallel use Pamela Ohashi, Campbell Family Inst., autoantibodies in demyelinating diseases of LAB/NTAL and LAT for ITAM signaling Ontario Cancer Inst., Is there immune in NK cells surveillance? Society for Leukocyte Biology (SLB) Silvia Vidal, McGill Center for Host Symposium: Migration, Pattern Recognition, Resistance, NK cells mediate epistatic and Megan Sykes, Massachusetts General and Activation: How Leukocytes Protect non-epistatic mechanisms of host resist- Hospital, T cell trafficking, GVHD and ance to cytomegalovirus infections their Hosts GVL Marcus Altfeld, Partners AIDS Research Claude Perreault, Inst. for Research in Saturday, May 13, 8:00 AM, Center, Massachusetts General Hospital, Immunology and Cancer, Univ. of Hynes Convention Center, Rm. 208 NK cell function in acute HIV-1 infection Montreal, T-cell based adoptive cancer Chair: Barrett J. Rollins, Dana-Farber Mary Carrington, SAIC-Frederick, Inc., immunotherapy Cancer Inst. NCI-Frederick, Influence of KIR Neil Berinstein, Cancer Program, Sanofi Speakers variability on viral disease Pasteur, Developing vaccines for patients Barrett J. Rollins, Dana-Farber Cancer Inst., with cancer Effects of inflammatory chemokines on Mexican Society of Immunology (MSI) Christopher Paige, Ontario Cancer Inst., breast cancer (Sociedad Mexicana de Inmunologia) Univ. Health Network, Role of IL-12 in Andrew Luster, Massachusetts General Symposium: Awakening Immunity initiating protective immunity in a Hospital, Calling in their cronies: amplifi- Saturday, May 13, 10:15 AM, murine model of leukemia cation of innate cell responses by chemokine- and lipid-induced recruitment Hynes Convention Center, Rm. 312 International Society for Interferon & Shannon Turley, Dana-Farber Cancer Inst., Chair: César González-Bonilla, Medical Cytokine Research (ISICR) Symposium Control of dendritic cell function by the Research Unit on Immunology and Saturday, May 13, 10:15 AM, tissue microenvironment Infectious Diseases, Infectology Hospital, National Medical Center "La Raza," Hynes Convention Center, Rm. 313 Douglas Golenbock, Univ. of Massachusetts Medical School, Mechanism of response to Mexican Inst. of Social Security, Mexico Chair: Thomas Hamilton, Cleveland Clinic CpG-rich DNA City Foundation Co-Chair: John Hiscott, McGill Univ., Jewish Speakers General Hospital Society for Mucosal Immunology (SMI) Vianney Ortiz-Navarrete, Molecular Symposium: Mucosal Immunity and Vaccine Biomedicine Department, CINVESTAV, Speakers Mexico City, Functional aspects of CRTAM Tom Maniatis, Harvard Univ., Distinct roles Saturday, May 13, 12:30 PM, expression on NKT and CD8 T cells of the I6B kinases TBK1 and IKKe in Hynes Convention Center, Rm. 306 Carlos Rosales, Immunology Department, anti-viral immunity Chair: Hiroshi Kiyono, The Univ. of Tokyo Biomedical Research Inst., National Keiko Ozato, NICHD, NIH, Real time Speakers Autonomous Univ. of Mexico, Mexico City, interaction of IRF proteins with Philip D. Smith, Univ. of Alabama at Immune response regulation by antibody chromatin in living dendritic cells Birmingham, Gut immunity against HIV receptors John Hiscott, McGill Univ., Jewish General Troy D. Randall, Trudeau Inst., Uniqueness Yvonne Rosenstein, Inst., Hospital, TLR-dependent and -independ- of NALT genesis for influenza vaccine National Autonomous Univ. of Mexico, ent signaling to the interferon antiviral development Cuernavaca Morelos, The timing of CD43 response Dennis W. Metzger, Albany Medical College, engagement modulates TCR-dependent Christine A. Biron, Brown Univ., Respiratory immune system for pneumo- cell responses Conditioning signaling events to modify coccal vaccine José Moreno, Medical Research Unit on the consequences of cytokine exposure Hiroshi Kiyono, The Univ. of Tokyo, M cell Autoimmune Diseases, Specialties targeted mucosal vaccine Hospital, National Medical Center "Siglo International Society of XXI", Mexican Inst. of Social Security, Neuroimmunology (ISNI) Symposium The Society for Natural Immunity (SNI) Mexico City, Traffic of MHCII and DM Saturday, May 13, 8:00 AM, Symposium: NK Cell Signaling and their during dendritic cell maturation Hynes Convention Center, Rm. 306 Response to Viral Infection Constantino López-Macías, Medical Chair: Kai W. Wucherpfennig, Dana-Farber Sunday, May 14, 8:00 AM, Research Unit on Immunochemistry, Cancer Inst., Harvard Medical School Hynes Convention Center, Rm. 309 Specialties Hospital, National Medical Chair: Mary Carrington, SAIC-Frederick, Center "Siglo XXI," Mexican Inst. of Social Speakers Inc., NCI-Frederick Security, Mexico City, The contribution of Kai W. Wucherpfennig, Dana-Farber Cancer Co-Chair: Daniel W. McVicar, NCI-Frederick antigen intrinsic adjuvant properties in Inst., Harvard Medical School, T cell Special Symposia, continued

the induction of life-lasting protective PsychoNeuroImmunology Research Society Role of epigenetics in neuro-immune antibody response (PNIRS) Symposium: Current Topics in communication César González-Bonilla, Medical Research Neuro-Immune Communication Gregory G. Freund, Univ. of Illinois, Unit on Immunology and Infectious Urbana-Champaign, Neuroimmunity Diseases, Infectology Hospital, National Saturday, May 13, 2:45 PM, in diabetes: resistance is futile Medical Center "La Raza," Mexican Inst. of Hynes Convention Center, Rm. 311 Annemieke Kavelaars, Univ. Medical Social Security, Mexico City, Salmonella Chair: Cobi J. Heijnen, Univ. Medical Center Center Utrecht, Neuro-immune as live vector for Trichinella vaccine Utrecht, President of PNIRS communication in inflammatory pain Speakers Denise Bellinger, Loma Linda Univ., Virginia Sanders, The Ohio State Univ., Neuro-immune communication in rheumatoid arthritis

Special Events

AAI Gala: Night at the Roxy (by invitation only) AAI/FASEB Career Resources Sunday, May 14, 6:30-9:30 PM A service of FASEB Career Resources, • Career development seminars Supported through an unrestricted educa- arranged by AAI Annual Meeting/ • Cover letter and resume critique tional grant from BD Biosciences IMMUNOLOGY 2006 workshops • Careers OnLine Applicant DataNet The FASEB Career Resources Center at Registration (year-round applicant resume AAI Business Meeting IMMUNOLOGY 2006 will feature: referrals) & Awards Presentations • AAI/FASEB Virtual Career Fair **Access to the Career Resources Center is (April 10-May 31) FREE to applicants who are registered for Monday, May 15, 12:45 PM, • Limited on-site interview facilities the AAI Annual Meeting/IMMUNOLOGY 2006 Hynes Convention Center, Ballroom A/B • 'Position Available' posting area Chair: M. Michele Hogan, AAI meeting subject to verification of meeting (unlimited postings included with registration; however, employers must regis- This session will include the annual report Employer Registration) ter at http://aaicareer.faseb.org/careernet. to AAI members on AAI and The Journal of Immunology business affairs, and will fea- ture the following AAI awards presentations:

• AAI Distinguished Service Award NIH Grant Seminar Workshops Leslie J. Berg, Univ. of The FASEB Career Resources and MARC This presentation is focused on the funda- Massachusetts Medical School Program Office in association with the mental principles of successful grant writing, For dedicated leadership as National Institutes of Health (NIH) will offer the most common reasons that grant appli- the Chair of the AAI Program a three-part grant seminar workshop in the cations fail, how to make an application Committee (2003-2006) Career Resources Center at the AAI Annual "reviewer friendly", how to meet the needs of Meeting/IMMUNOLOGY 2006. Dr. Anthony the reviewers and the funding agency, how to M. Coelho, Jr., Review Policy Officer at NIH, avoid the need for resubmission, and tips and • AAI Excellence in Mentoring Award will chair the workshops. Meeting registra- strategies for resubmitting, including what Norman R. Klinman, The tion is required to participate in the semi- should and what should not be done if resub- Scripps Research Inst. nars. mission becomes necessary. In recognition of exemplary career contributions to a Peer Review of NIH Grants-Part I NIH Mock Study Section-Part III future generation of scientists This workshop is focused on providing This workshop provides participants with an information on how to understand the peer overview of the working dynamics of peer review process, which is essential to compet- review at NIH. Participants will see the peer Pfizer-Showell Travel Award (recipient • ing successfully for funding. The workshops review process in action, followed by a ques- TBA) also provide an overview of how scientific tion-and-answer period. • AAI-Huang Foundation Trainee peer review is carried out at NIH. Achievement Awards (recipients TBA) IMPORTANT: Handouts and resource • AAI Junior Faculty Travel Awards materials will be provided on-site For fur- Grant Writing for Success-Part II ther information on the grant writing semi- (recipients TBA) This workshop provides an introduction nar workshops, please contact Carol Beischke AAI Minority Scientist Travel Awards • to factors that contribute to applications via email at [email protected]. (recipients TBA) that succeed in obtaining research funding. Cadmus Communications

Congratulates

The American Association of Immunologists on 90 years of supporting the scientific community through publication of The Journal of Immunology 1916-2006

AAI Courses in Immunology

The American Association of Immunologists 2006 Introductory Course in Immunology at the University of Pennsylvania, Philadelphia, PA, June 23-29, 2006

Course Co-Directors: Terri Laufer, MD, University of Pennsylvania; John Monroe, PhD, University of Pennsylvania

A comprehensive introduction to the basic principles of immunology offered by outstanding faculty in a two-part course. Suitable for students with a general biology background. Part I (June 24-26) covers the basic biology of the immune system. Part II (June 27-29) is a lecture series covering specific disciplines of immunology and emphasizing clinical relevance. Part II requires an understanding of basic immunology. Parts I and II may be taken separately at the discretion of the student. Course registration check-in starts June 23rd. The first lecture will start the morning of June 24th. 37 hours of CME will be offered.

APPLICATIONS MUST BE RECEIVED BY MAY 22, 2006 Attendance is limited to 220 registrants.

The American Association of Immunologists 2006 Advanced Course in Immunology at Stanford University • Stanford, California • July 15-21, 2006

Course Director: Olivia M. Martinez, PhD, Stanford University

An intensive course designed for serious students of immunology. Leading experts will present recent advances in understanding the biology of the immune system and its role in health and disease. This course is directed toward advanced trainees and scientists who wish to expand or update their understanding of the field. This is not an introductory course; attendees are required to have a firm understanding of the principles of immunology. Course registration check-in starts on July 15th; the first lecture will be that evening. 44 hours of CME will be offered. APPLICATIONS MUST BE RECEIVED BY JUNE 1, 2006 Attendance is limited to 220 registrants.

FOR INFORMATION, COURSE OUTLINES, AND REGISTRATION, VISIT: www.aai.org/Courses.htm For questions or assistance in registering contact [email protected] or 301-634-7178. Overseas applicants are advised to apply early for visas.