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Paul Marshall Macdonald Education B.S. from Colorado State University, 1978 M.S. from Georgia Institute of Technology, 1980 Ph.D

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Paul Marshall Macdonald Education B.S. from Colorado State University, 1978 M.S. from Georgia Institute of Technology, 1980 Ph.D Curriculum vitae Paul Marshall Macdonald Education B.S. from Colorado State University, 1978 M.S. from Georgia Institute of Technology, 1980 Ph.D. from Vanderbilt University, 1983 Professional experience Postdoctoral fellow in the lab of Dr. Tom Maniatis, Harvard University, 1984-1986 Postdoctoral fellow in the lab of Dr. Gary Struhl, Columbia University, 1987-1989 Assistant Professor, Department of Biological Sciences Stanford University, 1989-1996 Associate Professor with tenure, Department of Biological Sciences Stanford University, 1996-1999 Professor (1999- 2013) and Chair (2003-2013) Section of Molecular Cell and Developmental Biology Professor (2013-present) Department of Molecular Biosciences Mr. And Mrs. Robert P. Doherty, Jr. Regents Chair in Molecular Biology (1999-present) The University of Texas at Austin Fellowships and Awards Damon Runyon-Walter Winchell Postdoctoral Fellowship, 1984-1986 PEW Scholar in the Biomedical Sciences, 1990-1993 David and Lucile Packard Fellowship, 1990-1994 Fellow of the American Association for the Advancement of Science, 2004 Publications: Mosig, G., Luder, A., Rowen, L., Macdonald, P. and Bock, S. (1981). On the role of recombination and topoisomerase in primary and secondary initiation of T4 DNA replication. In: The Initiation of DNA Replication (D. Ray, ed.), Academic Press, N.Y., 277-295. Macdonald, P., Seaby, R.M. and Mosig, G. (1983). Initiator DNA from a primary origin and induction of a secondary origin of bacteriophage T4 DNA replication. In: Microbiology 1983 (D. Schlessinger, ed.), ASM, Washington, D.C., 111-116. Mosig, G., Macdonald, P., Lin, G., Levin, M. and Seaby, R. (1983). Gene expression and initiation of DNA replication of bacteriophage T4 in phage and host topoisomerase mutants. In: Mechanisms of DNA Replication and Recombination (N. Cozzarelli, ed.), Alan R. Liss, Inc., New York, 173-186. Macdonald, P. and Mosig, G. (1984). Cloning and physical mapping of an early region of the bacteriophage T4 genome. Genetics 106, 1-16. Macdonald, P., Kutter, E. and Mosig, G. (1984). Regulation of a bacteriophage T4 late gene, soc, which maps in an early region. Genetics 106, 17-27. Macdonald, P. and Hall, D.H. (1984). Genetic evidence for physical interactions between enzymes of nucleotide synthesis and proteins involved in DNA replication in bacteriophage T4. Genetics 107, 343-353. Macdonald, P. and Mosig, G. (1984). Regulation of a new bacteriophage T4 gene, 69, that spans an origin of DNA replication. EMBO Journal 3, 2863-2871. Mosig, G. and Macdonald, P. (1986). A new membrane-associated DNA replication protein, the gene 69 product of bacteriophage T4, shares a patch of homology with the Escherichia coli dnaA protein. Journal of Molecular Biology 189, 243-248. Macdonald, P.M., Ingham, P. and Struhl, G. (1986). Isolation, structure and expression of even-skipped: a second pair-rule gene of Drosophila containing a homeobox. Cell 47, 721-734. Macdonald, P.M. and Struhl, G. (1986). A molecular gradient in early Drosophila embryos and its role in specifying the body pattern. Nature 324, 537-545. Lawrence, P.A., Johnston, P., Macdonald, P. and Struhl, G. (1987). Borders of parasegments in Drosophila embryos are delimited by the fushi tarazu and even-skipped genes. Nature 328, 440-442. Macdonald, P.M. and Struhl, G. (1988). Cis-acting sequences responsible for anterior localization of bicoid mRNA in Drosophila embryos. Nature 336, 595-598. Goto, T., Macdonald, P. and Maniatis, T. (1989). Early and late periodic patterns of even skipped expression are controlled by distinct regulatory elements that respond to different spatial cues. Cell 57, 413-422. Struhl, G., Struhl, K. and Macdonald, P.M. (1989). The gradient morphogen bicoid is a concentration-dependent transcriptional activator. Cell 57, 1259-1273. Macdonald, P.M. (1990). bicoid mRNA localization signal: Phylogenetic conservation of function and RNA secondary structure. Development 110, 161-171. Kim-Ha, J., Smith, J.L. and Macdonald, P.M. (1991). oskar mRNA is localized to the posterior pole of the Drosophila oocyte. Cell 66, 23-35. Macdonald, P.M., Luk, S.K.-S. and Kilpatrick, M. (1991) Protein encoded by the exuperantia gene is concentrated at sites of bicoid mRNA accumulation in Drosophila nurse cells, but not in oocytes or embryos. Genes and Development 5, 2455-2466. Macdonald, P.M. (1992). The Drosophila pumilio gene: an unusually long transcription unit and an unusual protein. Development 114, 221-232. Smith, J.L., Wilson, J.E. and Macdonald, P.M. (1992). Overexpression of oskar directs ectopic activation of nanos and presumptive pole cell formation in Drosophila embryos. Cell 70, 849-859. Macdonald, P.M. (1992). The means to the ends: localization of maternal messenger RNAs. Seminars in Developmental Biology 3, 413-424. Wilson, J. and Macdonald, P.M. (1993) Formation of the germ line in Drosophila. Current Opinion in Genetics and Development 3, 562-565. Macdonald, P.M., Kerr, K., Smith, J.L. and Leask, A. (1993) RNA regulatory element BLE1 directs the early steps of bicoid mRNA localization. Development 118, 1233- 1243. Kim-Ha, J., Webster, P., Smith, J.L. and Macdonald, P.M. (1993) Multiple RNA regulatory elements mediate distinct steps in localization of oskar mRNA. Development 119, 169-178. Luk, S.K-S., Kilpatrick, M., Kerr, K. and Macdonald, P.M. (1994) Components acting in localization of bicoid mRNA are conserved among Drosophila species. Genetics 137, 521-530. Webster, P.J., Suen, J. and Macdonald, P.M. (1994) Drosophila virilis oskar transgenes direct body patterning but not pole cell formation or maintenance of mRNA localization in D. melanogaster. Development 120, 2027-2037. Kim-Ha, J., Kerr, K., and Macdonald, P.M. (1995) Translational regulation of oskar mRNA by bruno, an ovarian RNA binding protein, is essential. Cell 81, 403-412. Macdonald, P.M., Leask, A., and Kerr, K. (1995) exl protein specifically binds BLE1, a bicoid mRNA localization element, and is required for one phase of its activity. Proceedings of the National Academy of Science 92, 10787-10791. Wilson, J.E., Connell, J.E., and Macdonald, P.M. (1996) aubergine enhances oskar translation in the Drosophila ovary. Development 122, 1631-1639. Macdonald, P.M. and Smibert, C.A. (1996) Translational regulation of maternal mRNAs. Current Opinion in Genetics and Development 6, 403-407. Wilson, J.E., Connell, J.E., Schlenker, J.D. and Macdonald, P.M. (1996) A novel genetic screen for genes involved in posterior body patterning in Drosophila. Developmental Genetics 19, 199-209 Smibert, C.A., Wilson, J.E., Kerr, K. and Macdonald, P.M. (1996) smaug protein represses translation of unlocalized nanos mRNA in the Drosophila embryo. Genes & Development 10, 2600-2609. Webster, P.J., Liang, L., Berg, C.A., Lasko, P. and Macdonald, P.M. (1997) Translational repressor bruno plays multiple roles in development and is widely conserved. Genes & Development 11, 2510-2521. Macdonald, P.M. and Kerr, K. (1997). Redundant RNA recognition events in bicoid mRNA localization. RNA 3, 1413-1420. Dubowy, J. and Macdonald, P.M. (1998) Localization of mRNAs to the oocyte is common in Drosophila ovaries. Mechanisms of Development 70, 193-195. Macdonald, P.M. and Kerr, K. (1998) Mutational analysis of an RNA recognition element that mediates localization of bicoid mRNA. Molecular and Cellular Biology 18, 3788- 3795. Webster, P.J. and Macdonald, P.M. (1998) Screening an expression library for RNA- binding proteins using a solution-based assay. In Methods in Molecular Biology: RNA- Protein Interaction Protocols, (ed. S.R. Haynes), The Humana Press Inc., Totowa, NJ. Arn, E.A. and Macdonald, P.M. (1998) Motors driving mRNA localization – new insights from in vivo imaging. Cell 95, 151-154. Lie, Y.S. and Macdonald, P.M. (1999) Apontic binds the translational repressor Bruno and is implicated in regulation of oskar mRNA translation. Development 126, 1129- 1138. Lie, Y.S. and Macdonald, P.M. (1999) Translational regulation of oskar mRNA occurs independent of the cap and poly(A) tail in Drosophila ovarian extracts. Development 126, 4989-4996. Smibert, C.A., Lie, Y.S., Shillinglaw, W., Henzel, W., and Macdonald, P.M. (1999) Smaug, a novel and conserved protein, contributes to repression of nanos translation in vitro. RNA 5, 1535-1547. Lie, Y.S. and Macdonald, P.M. (2000) In vitro translation of exogenous mRNAs in extracts prepared from Drosophila ovaries and embryos. Biochem Biophys Res Comm 270, 473-481. Macdonald, P.M. Diversity in translational regulation. (2001) Current Opinion in Cell Biology 13, 326-331. Mancebo, R., Zhou, X., Shillinglaw, W., Henzel, W. and Macdonald, P.M. (2001) BSF binds specifically to the bicoid mRNA and contributes to its stabilization. Molecular and Cellular Biology 21, 3462-3471. Harris, A.N. and Macdonald, P.M. (2001) aubergine encodes a Drosophila polar granule component required for pole cell formation and related to eIF2C. Development 128, 2823-2832. Arn, E.A. and Macdonald, P.M. (2001) RNA localization goes direct. Direct injection of RNA provides a new view of localization during Drosophila oogenesis. Developmental Cell 1, 155-156. Arn, E.A., Cha, B.J., Theurkauf, W.E. and Macdonald, P.M. (2003) Recognition of a bicoid mRNA localization signal by a protein complex containing Swallow, Nod and RNA binding proteins. Developmental Cell 4, 41-51. Snee, M.J. and Macdonald, P.M. (2004) Live imaging of nuage and polar granules: evidence against a precursor-product relationship, and a novel role for Oskar in stabilization of polar granule components. Journal of Cell Science 117, 2109-2120. Macdonald, P.M. (2004) Translational Regulation: A Cup Half Full. Current Biology 14, R282-R283. Braat, A.K., Yan, N., Arn, E., Harrison, D. and Macdonald, P.M. (2004) Localization- dependent Oskar protein accumulation: control after the initiation of translation. Developmental Cell 7, 125-131. Yan, N. and Macdonald, P.M. (2004) Genetic interactions of Drosophila melanogaster arrest reveal roles for translational repressor Bruno in accumulation of Gurken and activity of Delta.
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