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US008747915B1

(12) United States Patent (10) Patent No.: US 8,747,915 B1 Giampapa (45) Date of Patent: Jun. 10, 2014

(54) DETARY SUPPLEMENT SYSTEM FOR (56) References Cited MULTIFUNCTIONAL -AGING MANAGEMENT AND METHOD OF USE U.S. PATENT DOCUMENTS 5,895,652 A * 4/1999 Giampapa ...... 424, 19517 (76) Inventor: Vincent C. Giampapa, Montclair, NJ 2005/OOO8690 A1* 1/2005 Miller ...... 424/451 (US) * cited by examiner (*) Notice: Subject to any disclaimer, the term of this Primary Examiner — Rosanne Kosson patent is extended or adjusted under 35 (74) Attorney, Agent, or Firm — Jerry C. Harris, Jr.; Conley U.S.C. 154(b) by 27 days. Rose, P.C. (57) ABSTRACT A system includes a dietary Supplement (21) Appl. No.: 13/573,386 composition for oral administration by an individual in the morning, the composition, including (a) a telomere mainte (22) Filed: Sep. 13, 2012 nance complex including: Purslane extract (aerial parts); Tur meric rhizome extract (95% curcuminoids); Quercetin dehy drate, Cayenne pepper fruit; Vanadium (as Vanadyl Sulfate); Related U.S. Application Data Fenugreek seed; Astragalus root extract, Omega complex including linoleic acid; alpha-linolenic acid, oleic (60) Provisional application No. 61/534,673, filed on Sep. acidborage seed oil gamma-linolenic acid), evening primrose 14, 2011. oil fish body oil (eicosapentaenoic acid; docosahexaenoic acid); (b) a calorie restriction mimetics and gene expression complex including Trans-resveratrol (from Polygonum cus (51) Int. C. pidatum root extract); Pterostilbene Fisetin 50% (Buxus A6 IK36/00 (2006.01) microphila Sieb (stem and leaf: Alpha , Coenzyme A2.3L L/48 (2006.01) Q-10, Betaine HCl, (from methylsulfonylmethane); (52) U.S. C. L- tartrate; L-Carnitine HCl, and (c) a free radical USPC ...... 424/725; 426/531; 426/542: 426/615 scavenger complex, including Green tea leaf extract catechin (58) Field of Classification Search and polyphenols); Anthocyanins (from bilberry fruit and USPC ...... 424/725; 426/531, 542, 615 grape skin extracts). See application file for complete search history. 1 Claim, No Drawings US 8,747,915 B1 1. 2 DETARY SUPPLEMENT SYSTEM FOR polyphenols), 40-60 mg Anthocyanins (from bilberry fruit MULTIFUNCTIONAL ANT-AGING and grape skin extracts), 4-6 mg MANAGEMENT AND METHOD OF USE DETAILED DESCRIPTION OF THE INVENTION CROSS REFERENCE TO RELATED APPLICATION In one embodiment, the present invention provides a dietary Supplement system for Supporting multifunctional This application claims the benefit under 35 USC 119(e) anti-aging management. In one embodiment, the nutritional provisional patent application Ser. No. 61/534,673, filed Sep. Supplement system comprises two dietary Supplement com 14, 2011, which is hereby incorporated by reference in its 10 positions, each for oral administration by an individual at a entirety. specific time of a day. In one embodiment, each of the two dietary Supplement FIELD OF THE INVENTION compositions comprises multiple Sub-functional groups of components, including telomere maintenance complex, calo This invention relates to a dietary Supplement system for 15 rie restriction mimetics and gene expression complex, free multifunctional anti-aging management and method of use. radical scavenger complex, DNA repair complex, stem cell maintenance complex, and cell regulation complex. Further BACKGROUND OF THE INVENTION more, the dietary Supplement compositions also comprise multiple and minerals. One of the two Supplement The aging process is believed to relate to the failure of cell compositions is designated for oral administration in the components such as the cell nucleus to continue to replicate morning, and hence is referred to as AM dietary Supplement otherwise healthy cells. This is believed to occur as a result of composition, or AM composition hereinafter, and the other damage which occurs to essential cell components resultant Supplement composition is designated for oral administration of decrease in levels of key chemical agents or substances 25 in the evening, and hence is referred to as PM dietary supple involved in cellular regulation and production. These agents ment composition, or PM composition hereinafter. will typically diminish as a result of reduction in efficiency Unless defined otherwise, all technical and scientific terms overtime of glands and organs in the human body. Reductions used herein have the same meaning as commonly understood in Such key chemical agents are believed to cause damage to by one having ordinary skills in the art to which the invention the RNA and DNA in each cell nucleus which thereby reduces 30 belongs. It should also be understood that various individual the ability of the cell to reproduce itself which ultimately components used herein may have more than one type of brings on the aging process which yet further accelerates the properties. decrease in body's production of the key agents. Therefore, In the dietary Supplement compositions, telomere mainte the essential problem in anti-aging management is that of nance complex comprises a group of components that indi maintaining appropriate levels of key metabolic agents so that 35 vidually and/or jointly Support maintaining telomere of the the genetic material within each cell will not become dam aged or otherwise lose efficiency. chromosome. The telomere maintenance complex includes, Therefore, it is desirable to have improved dietary supple but not limited to, purslane extract (aerial parts), turmeric ment compositions that provide nutrients and Substances to rhizome extract containing curcuminoids, quercetin dehy effectively support optimal cellular functions for the purpose 40 drate, cayenne pepper fruit, Vanadium, fenugreek seed, of anti-aging management at both the cellular and organ astragalus root extract, Valerian root, omega fatty acid com levels. plex including linoleic acid, alpha-linolenic acid, and oleic acid, borage seed oil, evening primrose oil and fish body oil. SUMMARY OF THE INVENTION The calorie restriction mimetics and gene expression com 45 plex comprises a group of components that individually and/ A dietary Supplement system includes a first dietary or jointly support calorie restriction mimetics and gene Supplement composition for oral administration by an indi expression. The calorie restriction mimetics and gene expres vidual in the morning, said first composition, comprising: (a) sion complex includes, but not limited to, trans-resveratrol, a telomere maintenance complex comprising: Purslane Such as from extract of polygonum cuspidatum root or grape extract (aerial parts), 4-6 mg: Turmeric rhizome extract (95% 50 skin, pterostilbene, fisetin, alpha lipoic acid, coenzyme Q-10, curcuminoids), 20-30 mg; Quercetin dehydrate, 12-18 mg: betaine HCl, sulfur, such as from methylsulfonylmethane, Cayenne pepper fruit, 8-12 mg; Vanadium (as Vanadyl Sul L-carnitine tartrate, L-carnitine HCl, acetyl-L-carnitine, and fate), 20-30 mcg: Fenugreek seed, 20-30 mg. Astragalus root avocado extract. extract, 8-12 mg; Omega fatty acid complex, 160-240 mg. The free radical scavenger complex comprises a group of including linoleic acid (10.6%), alpha-linolenic acid (1.3%), 55 oleic acid (1.6%), borage seed oil (10% gamma-linolenic components that individually and/or jointly function as anti acid), evening primrose oil (4.8% GLA), fish body oil (4.5% oxidant and reduce free radicals. The free radical scavenger eicosapentaenoic acid, 3.0% docosahexaenoic acid); (b) a complex includes, but not limited to, green tea leaf extract calorie restriction mimetics and gene expression complex containing catechin and polyphenols, anthocyanins such as comprising: Trans-resveratrol (from Polygonum cuspidatum 60 from bilberry fruit and grape skin extracts, ginkgo biloba leaf root extract), 1.6-2.4 mg. Pterostilbene (99%), 1.6-2.4 mg: extract containing ginkgo flavonglycosides and sesquiter Fisetin 50% (Buxus microphila Sieb (stem and leaf)), 1.6-2.4 pene lactones, cruciferous vegetable concentrate (broccoli, mg; Alpha lipoic acid, 8-12 mg: Coenzyme 0-10, 4-6 mg: kale, radish) containing glucosinolates, grape skin extract Betaine HCl, 3.2–4.8 mg: Sulfur (from methylsulfonyl containing total phenolics, tomato extract contain methane), 1-1.5 mg. L-Carnitine tartrate, 8-12 mg; L-Car 65 ing lycopene, rosemary extract (aerial parts), pycnogenol nitine HCl, 4-6 mg; and (c) a free radical scavenger complex, (pine bark extract), lutein Such as from marigold flower comprising: Green tea leaf extract (40% catechin and extract, and green barley grass (aerial parts). US 8,747,915 B1 3 4 The DNA repair complex comprises a group of compo TABLE 1 nents that individually and/or jointly support DNA repairing in both nuclei and mitochondria. The DNA repair complex AM Dietary Supplement Composition includes, not limited to, water extract of uncaria tomentosa Amount Per containing carboxy alkyl esters, N-acetyl-cysteine, inositol 5 Components Serving hexaphosphate, and . The stem cell maintenance complex comprises a group of Telomere Maintenance Complex components that individually and/or jointly support optimal Purslane extract (aerial parts) 4-6 mg Turmeric rhizome extract (95% curcuminoids) 20-30 mg maintenance of stem cells and gene expression. The stem cell 10 Quercetin dihydrate 12-18 mg maintenance complex includes, but not limited to, chlorella Cayenne pepper fruit 8-12 mg Vanadium (as vanadyl Sulfate) 20-30 mcg algae, spirulina algae, klamath blue-green algae, fuXOXanthin Fenugreek seed 20-30 mg seaweed (whole plant), nori seaweed extract or brown see Astragalus root extract 8-12 mg weed extract. Omega fatty acid complex including linoleic 160-240 mg acid (10.6%), alpha-linolenic acid (1.3%), oleic acid The cell regulation complex comprises a group of compo 15 (1.6%)), borage seed oil (10% gamma-linolenic acid), nents that individually and/or jointly support optimal cell evening primrose oil (4.8% GLA), fish body oil (4.5% eicosapentaenoic acid, 3.0% docosahexaenoic acid) regulation. The cell regulation complex includes, but not Calorie Restriction Mimetics and limited to, gotu kola leaf, Such as from Gene Expression Complex soy , DMAEbitartrate, Cordyceps sinensis mushroom extract containing cordyceptic acid, royal jelly 3x containing Trans-resveratrol (from Polygonum cuspidatum 1.6-2.4 mg root extract) 10-HDA, I-, , L-phenylalanine, L-tyrosine, Pterostilbene (99%) 1.6-2.4 mg inositol, L-arginine, L-ornithine, seed extract, probi Fisetin 50% (Buxus microphila Sieb (stem and leaf)) 1.6-2.4 mg Alpha lipoic acid 8-12 mg otic blend ( acidophilus, lactobacillus plan Coenzyme Q-10 4-6 mg tarum, bifidum and ), 25 Betaine HCI 3.2–4.8 mg amylase, neutral protease, cellulase, lactase, and lipase. Sulfur (from methylsulfonylmethane) 1-1.5 mg Multiple vitamins in the dietary Supplement compositions L-Carnitine tartrate 8-12 mg L-Carnitine HCI 4-6 mg include, but not limited to, A, , vitamin D, Free Radical Scavenger Complex , , thiamin, riboflavin, niacin, vitamin B6, , vitamin B12, biotin, and . 30 Green tea leaf extract (40% catechin and polyphenols) 40-60 mg Anthocyanins (from bilberry fruit and grape 4-6 mg The minerals in the dietary Supplement compositions skin extracts) include, but not limited to, , , , , Ginkgo biloba leaf extract (24% ginkgo 40-60 mg flavonglycosides, 6% sesquiterpene lactones) , , , and . Option Green barley grass (aerial parts) 20-30 mg ally, the minerals may further include transitional metal trace 35 DNA Repair Complex elements such as iridium, rhodium, ruthenium, and/or other water extract of incaria to mentosa 100-150 mg transitional metal trace elements. (containing carboxyalkyl esters) In addition to the active components described above, each N-acetyl-cysteine 10-15 mg Inositol hexaphosphate 1.6-2.4 mg composition may further include pharmaceutically accept Stem Cell Maintenance Complex able medium. Pharmaceutically acceptable medium is known 40 Chiorella algae 20-30 mg to those of ordinary skilled in the art. In one exemplary Spiritiina algae 40-60 mg embodiment, the medium includes microcrystalline cellu Klamath blue-green algae 60-90 mg Fuxoxanthin seaweed (whole plant) 20-30 mg lose, croscarmellose , Stearic acid, calcium silicate, Nori seaweed extract 1.6-2.4 mg Stearate, silica and film coat ingredients such as 45 Cell Regulation Complex hypromellose, hydroxypropyl cellulose, and polyethylene Gotukola leaf 8-12 mg glycol. The dietary Supplement compositions can be made Phosphatidylcholine (from soy lecithin) 20-30 mg into various forms suitable for oral administration, for DMAEbitantrate 20-30 mg example powder, granules, capsules, tablets, or liquid. Cordyceps Sinensis mushroom extract 10-15 mg 50 (1% cordyceptic acid) In the AM and PM dietary supplement compositions, each Royal jelly 3X (5% 10-HDA) 8-12 mg Sub-functional group may have some differences in the com L-Glutamine 40-60 mg Taurine 20-30 mg ponents described above, and the amount or concentration of L-Phenylalanine 20-30 mg individual components may be different, since the effects and L-Tyrosine 20-30 mg needs between the two compositions provided at different 55 Guarana seed extract (20% caffeine) 32-48 mg Amylase 480-720 units times of a day may be different. Neutral protease 120-180 units In one exemplary embodiment, the AM and PM dietary Cellulase 4-6 units Supplement compositions and the preferred amount of indi Lactase 80-120 units Lipase 2.6-3.9 units vidual components are provided below in Table 1 and Table 2, Vitamins respectively. It is noted that the amount of individual compo 60 nents is defined as the amount in one dosage or the amount of (as retinyl palmitate and 85% as 1440-2,160 IU per serving, which can be contained in one or more capsules beta-caroteine) Vitamin C (as aScorbyl palmitate and ascorbic acid) 80-120 mg or tablets. For example, 20 to 30 mg of taurine in one dosage Vitamin D (as cholecalciferol) 32-48 IU can be provided in one or two capsules. The size and number Vitamin E (as d-alpha tocopheryl Succinate and 40-60 IU of capsules may depend on the manufacturability, which may 65 from mixed natural ) further depend on the properties of the components and the Vitamin K (as phytonadione) 60-90 mcg pharmaceutically acceptable medium used therein. US 8,747,915 B1 5 6 TABLE 1-continued TABLE 2-continued AM Dietary Supplement Composition PM Dietary Supplement Composition

Amount Per Amount Per Components Serving Component Serving N-Acetyl cysteine 6.4-9.6 mg Thiamin (as thiamin HCI) 4-6 mg Melatonin 0.4–0.6 mg Riboflavin (as riboflavin and riboflavin-5-phosphate) 3.2–4.8 mg Stem Cell Maintenance Complex Niacin (as niacinamide and niacin) 56-84 mg Vitamin B (as pyridoxine HCl and pyridoxal 9.6-14.4 mg 10 Chiorella algae 20-30 mg 5-phosphate) Spiritiina algae 12-18 mg Folate (as folic acid) 40-60 mcg Klamath bluegreen algae 36-54 mg Vitamin B2 (as ) 64-96 mcg Fucoxanthin Seaweed (whole plant) 20-30 mg Biotin 40-60 mcg Brown seaweed extract 4-6 mg Pantothenic acid (as D-calcium pantothenate) 9.6-14.4 mg Cell Regulation Complex Minerals 15 Phosphatidylcholine (from soy lecithin) 16-24 mg Iodine (as iodide and from kelp) 24-36 mcg Cordyceps Sinensis mushroom extract 6.6-9.9 mg Calcium (as calcium carbonate and citrate) 240-360 mg (1% cordycepic acid) Zinc (as Zinc glycinate) 1.6-2.4 mg Royal jelly 3x (5% 10-HDA) 7.2-10.8 mg Selenium (as selenomethionine) 24-36 mcg nositol 40-60 mg Copper (as copper lysinate) 0.16-0.24 mg L-Glutamine 200-300 mg Manganese (as manganese gluconate) 0.16-0.24 mg L-Arginine (as L-arginine HCI) 128-192 mg L-Ornithine (as L-ornithine HCI) 96-144 mg Chromium (as chromium polynicotinate) 40-60 mcg Taurine 12.8-19.2 mg Molybdenum (as sodium molybdate) 6.4-9.6 mg L-Tyrosine 16-24 mg Transitional metal trace elements including 10-90 g blend including Lactobacilius acidophilus, 40-60 mil iridium, rhodium, ruthenium , Bifidobacterium bifidum lion 25 and Lactobacilius casei CFU Amylase 320-480 units Neutral protease 80-120 units TABLE 2 Lactase 52-78 units Lipase 12.8-19.2 units PM Dietary Supplement Composition Vitamins 30 Amount Per Vitamin A (as retinyl palmitate and 85% from 1,120-1680 IU Component Serving natural mixed carotenoids) Vitamin C (as aScorbic acid and ascorbyl palmitate) 160-240 mg Telomere Maintenance Complex Vitamin D (as cholecalciferol) 24-36 IU Vitamin E (as d-alpha-tocopheryl Succinate and from 32-48 IU Purslane extract (aerial parts) 4-6 mg 35 mixed natural tocopherols) Turmeric rhizome extract (95% curcuminoids) 20-30 mg Vitamin K (as phytonadione) 60-90 mcg Quercetin dihydrate 12-18 mg Thiamin (as thiamin HCI) 2-3 mg Cayenne pepper fruit 8-12 mg Riboflavin (as riboflavin and riboflavin-5-phosphate) 4-6 mg Vanadium (as vanadyl sulfate) 16-24 mcg Niacin (as niacinamide and niacin) 56-84 mg Fenugreek seed 16-24 mg Vitamin B (as pyridoxine HCl and 6-9 mg Valerian root 24-36 mg pyridoxal-5-phosphate) Omega fatty acid complex including linoleic acid 160-240 mg 40 Folate (as folic acid) 64-96 mcg (10.6%), alpha-linolenic acid (1.3%), oleic acid Vitamin B12 (as cyanocobalamin) 96-144 mcg (1.6%), borage seed oil (10% gamma-linolenic acid), Biotin 32-48 mcg evening primrose oil (4.8% GLA), fish body oil Pantothenic acid (as D-calcium pantothenate) 16-24 mg (4.5% eicosapentaenoic acid, 3.0% docosahexaenoic Minerals acid) Calorie Restriction Mimetics and Gene Expression Complex 45 Iodine (as potassium iodide and from kelp) 9.6-14.4 mcg Magnesium (as magnesium oxide and glycinate) 106-159 mg Trans-resveratol (as Polygontin cuspidatum root 1.6-2.4 mg Zinc (as Zinc glycinate) 1.2-1.8 mg extract or grape skin extract) Selenium (as selenomethionine) 19.2-28.8 mcg Pterostilbene 1.6-2.4 mg Copper (as copper lysinate) 0.08-0.12 mg Fisetin 50% (Buxus microphila Sieb (stem and leaf)) 1.6-2.4 mg Manganese (as manganese gluconate) 0.08-0.12 mg Alpha-lipoic acid 8-12 mg 50 Chromium (as chromium polynicotinate) 32-48 mcg Coenzyme Qo 2.8–4.2 mg Molybdenum (as sodium molybdate) 6.4-9.6 mcg Betaine (as betaine-HCl) 2-3 mg Transitional metal trace elements including 10-90 g Sulfur (from methylsulfonylmethane) 0.8-1.2 mg iridium, rhodium, ruthenium L-Carnitine tartrate 8-12 mg Acetyl-L-carnitine 4-6 mg Free Radical Scavenger Complex Preferably, the AM dietary supplement composition is 55 orally administered in the morning, and the PM dietary Cruciferous vegetable concentrate (broccoli, 32-48 mg Supplement composition is orally administered in the kale, radish) (2% glucosinolates) Grape skin extract (37% total phenolics) 16-24 mg evening, for example at the bed time. Preferably, the dietary Tomatolycopene extract (20% lycopene) 1.6-2.4 mg Supplement compositions are administered daily as dietary or Rosemary 4:1 extract (aerial parts) 2.6-3.9 mg nutritional Supplements. The compositions can be taken with Pycnogenol (pine bark extract) 1.32-1.98 mg 60 or without food. Lutein (from marigold flower extract) 0.64–0.96 mg The unique combination of the above described telomere Green barley grass 8-12 mg maintenance complex, calorie restriction mimetics and gene DNA Repair Complex expression complex, free radical scavenger complex, DNA Water extract of incaria tomentosa (containing 100-150 mg repair complex, stem cell maintenance complex, and cell carboxyalkyl esters) 65 regulation complex provides synergetic effects for optimal nositol hexaphosphate 1.6-2.4 mg cellular function. The synergetic effects provide desired calo rie restriction mimetics, reduce age related deteriorations in US 8,747,915 B1 7 8 telomere maintenance, stem cell function, cell regulation and TABLE 3-continued gene expression, reduce free radicals at cellular level, and enhance DNA repair in both nuclei and mitochondria. More Example AM Dietary Supplement Composition over, the Supplement compositions, through various compo Amount Per nents and their combination, further have anti-inflammation 5 Components Serving and anti-oxidation properties, and desired functions in regu lating glycation and methylation. Therefore, the dietary Cell Regulation Complex Supplement compositions provide a multifunctional and Gotukola leaf 10 mg effective anti-aging management system. Phosphatidylcholine (from soy lecithin) 25 mg 10 DMAEbitantrate 25 mg The following example further describes and demonstrates Cordyceps Sinensis mushroom extract (1% cordyceptic acid) 12.5 mg Royal jelly 3X (5% 10-HDA) 10 mg embodiments within the scope of the present invention. The L-Glutamine 50 mg examples are given solely for the purpose of illustration and Taurine 25 mg are not to be construed as limitations of the present invention, L-Phenylalanine 25 mg as many variations thereof are possible without departing 15 L-Tyrosine 25 mg Guarana seed extract (20% caffeine) 40 mg from the spirit and scope of the invention. Amylase 600 units Neutral protease 150 units Cellulase 5 units Example 1 Lactase 100 units Lipase 25 units An AM dietary supplement composition shown in Table 3 Vitamins below was prepared, with the processes known in the art. The Vitamin A (as retinyl palmitate and 85% as beta-carotene) 1,800 IU amount per serving described was provided in two capsules. Vitamin C (as aScorbyl palmitate and ascorbic acid) 100 mg Vitamin D (as cholecalciferol) 40 IU Vitamin E (as d-alpha tocopheryl Succinate and from 50 IU TABLE 3 25 mixed natural tocopherols) Example AM Dietary Supplement Composition Vitamin K (as phytonadione) 75 mcg Thiamin (as thiamin HCI) 5 mg Amount Per Riboflavin (as riboflavin and riboflavin-5-phosphate) 4 mg Components Serving Niacin (as niacinamide and niacin) 70 mg 30 Vitamin B (as pyridoxine HCl and pyridoxal 5-phosphate) 12 mg Telomere Maintenance Complex Folate (as folic acid) 50 mcg Vitamin B12 (as cyanocobalamin) 80 mcg Purslane extract (aerial parts) 5 mg Biotin 50 mcg Turmeric rhizome extract (95% curcuminoids) 25 mg Pantothenic acid (as D-calcium pantothenate) 12 mg Quercetin dihydrate 15 mg Minerals Cayenne pepper fruit 10 mg 35 Vanadium (as vanadyl sulfate) 25 mcg Iodine (as potassium iodide and from kelp) 30 mcg Fenugreek seed 25 mg Astragalus root extract 10 mg Calcium (as calcium carbonate and citrate) 300 mg Omega fatty acid complex including linoleic acid (10.6%), 200 mg Zinc (as Zinc glycinate) 2 alpha-linolenic acid (1.3%), oleic acid (1.6%), Selenium (as selenomethionine) 30 mcg borage seed oil (10% gamma-linolenic acid), Copper (as copper lysinate) 0.2 mg evening primrose oil (4.8% GLA), fish body oil 40 Manganese (as manganese gluconate) 0.2 mg (4.5% eicosapentaenoic acid, 3.0% docosahexaenoic acid) Chromium (as chromium polynicotinate) 50 mcg Calorie Restriction Mimetics and Gene Expression Complex Molybdenum (as sodium molybdate) 8 mg Other ingredients: Microcrystalline cellulose, croscarmellose sodium, stearic acid, calcium Trans-resveratrol (from Polygonum cuspidatum root extract) 2 mg silicate, magnesium stearate, silica and film coatingredients (hypromellose, hydroxypropyl Pterostilbene (99%) 2 mg cellulose, and polyethylene glycol), Fisetin 50% (Buxus microphila Sieb (stem and leaf)) 2 mg 45 Alpha lipoic acid 10 mg Coenzyme Q-10 5 mg Betaine HCI 4 mg Example 2 Sulfur (from methylsulfonylmethane) 1.25 mg L-Carnitine tartrate 10 mg L-Carnitine HCL 5 mg 50 A PM dietary supplement composition shown in Table 3 Free Radical Scavenger Complex below was prepared, with the processes known in the art. The Green tea leaf extract (40% catechin and polyphenols) 50 mg amount per serving described was provided in two capsules. Anthocyanins (from bilberry fruit and grape skin extracts) 5 mg Ginkgo biloba leaf extract (24% ginkgo flavonglycosides, 6% 50 mg TABLE 4 sesquiterpene lactones) 55 Green barley grass (aerial parts) 25 mg Example PM Dietary Supplement Composition DNA Repair Complex Amount Per Water extract of uncaria tomentosa 125 mg Components Serving (containing carboxyalkyl esters) N-acetyl-cysteine 12.5 mg Telomere Maintenance Complex Inositol hexaphosphate 2 mg 60 Stem Cell Maintenance Complex Purslane extract (aerial parts) 5 mg Turmeric rhizome extract (95% curcuminoids) 25 mg Chlorella algae 25 mg Quercetin dihydrate 15 mg Spiritiina algae 50 mg Cayenne pepper fruit 10 mg Klamath blue-green algae 75 mg Vanadium (as vanadyl Sulfate) 20 mcg Fuxoxanthin seaweed (whole plant) 25 mg 65 Fenugreek seed 20 mg Nori seaweed extract 2 mg Valerian root 30 mg US 8,747,915 B1 9 10 TABLE 4-continued TABLE 4-continued Example PM Dietary Supplement Composition Example PM Dietary Supplement Composition

Amount Per Amount Per Components Serving Components Serving Omega fatty acid complex including linoleic acid (10.6%), 200 mg Minerals alpha-linolenic acid (1.3%), oleic acid (1.6%), borage seed oil (10% gamma-linolenic acid), Iodine (as potassium iodide and from kelp) 12 mcg evening primrose oil (4.8% GLA), fish body oil Magnesium (as magnesium oxide and glycinate) 132.5 mg (4.5% eicosapentaenoic acid, 3.0% docosahexaenoic acid) 10 Zinc (as Zinc glycinate) 1.5 mg Calorie Restriction Mimetics and Gene Expression Complex Selenium (as selenomethionine) 24 mcg Copper (as copper lysinate) 0.1 mg Resveratol (as Polygontin cuspidatum root extract) 2 mg Manganese (as manganese gluconate) 0.1 mg Pterostilbene 2 mg Chromium (as chromium polynicotinate) 40 mcg Fisetin 50% (Buxus microphila Sieb (stem and leaf)) 2 mg Molybdenum (as sodium molybdate) 8 mcg Alpha-lipoic acid 10 mg 15 Coenzyme Qo 3.5 mg Other ingredients: Microcrystalline cellulose, croscarmellose sodium, stearic acid, calcium Betaine (as betaine-HCl) 2.5 mg silicate, magnesium stearate, silica and film coatingredients (hypromellose, hydroxypropyl Sulfur (from methylsulfonylmethane) 1 mg cellulose, and polyethylene glycol), L-Carnitine tartrate 10 mg Acetyl-L-carnitine 5 mg All publications, patent applications, patents, and other Free Radical Scavenger Complex references mentioned herein are incorporated by reference in their entirety. Cruciferous vegetable concentrate (broccoli, kale, 40 mg While the invention has been disclosed in connection with radish) (2% glucosinolates) Grape skin extract (37% total phenolics) 20 mg certain preferred embodiments, this should not be taken as a Tomatolycopene extract (20% lycopene) 2 mg limitation to all of the provided details. Modifications and Rosemary 4:1 extract (aerial parts) 3.25 mg variations of the described embodiments may be made with Pycnogenol (pine bark extract) 1.65 mg 25 Lutein (from marigold flower extract) 0.8 mg out departing from the spirit and scope of the invention, and Green barley grass 10 mg other embodiments should be understood to be encompassed DNA Repair Complex in the present disclosure as would be understood by those of Water extract of uncaria tomentosa (containing carboxy 125 mg ordinary skill in the art. alkyl esters) 30 Inositol hexaphosphate 2 mg What is claimed is: N-acetyl cysteine 8 mg Melatonin 0.5 mg 1. A dietary supplement system comprising: Stem Cell Maintenance Complex (i) a first dietary Supplement composition for oral admin istration by an individual in the morning, said first com Chlorella algae 25 mg Spiritiina algae 15 mg 35 position comprising: Klamath bluegreen algae 45 mg (a) a telomere maintenance complex comprising: Fucoxanthin Seaweed (whole plant) 25 mg Purslane extract (aerial parts), 4-6 mg, Turmeric rhizome Brown seaweed extract 5 mg extract (95% curcuminoids), 20-30 mg; Quercetin dehy Cell Regulation Complex drate, 12-18 mg; Cayenne pepper fruit, 8-12 mg; Vana Phosphatidylcholine (from soy lecithin) 20 mg 40 dium (as Vanadyl Sulfate), 20-30 mcg, Fenugreek seed, Cordyceps Sinensis mushroom extract (1% cordycepic acid) 8.25 mg 20-30 mg. Astragalus root extract, 8-12 mg; and Omega Royal jelly 3x (5% 10-HDA) 9 mg fatty acid complex, 160-240 mg, including linoleic acid Inositol 50 mg L-Glutamine 250 mg (10.6%), alpha-linolenic acid (1.3%), oleic acid (1.6%), L-Arginine (as L-arginine HCI) 160 mg borage seed oil (10% gamma-linolenic acid (GLA)), L-Ornithine (as L-ornithine HCI) 120 mg 45 evening primrose oil (4.8% GLA); and fish body oil Taurine 16 mg (4.5% eicosapentaenoic acid, 3.0% docosahexaenoic L-Tyrosine 20 mg Probiotic blend including Lactobacilius acidophilus, 50 mil acid); Lactobacilius plantarum, Bifidobacterium bifidum lion (b) a calorie restriction mimetics and gene expression com and Lactobacilius casei CFU plex comprising: Amylase 400 units 50 Trans-resveratrol (from Polygonum cuspidatum root Neutral protease 100 units Lactase 65 units extract), 1.6-2.4 mg. Pterostilbene (99%), 1.6-2.4 mg: Lipase 16 units Fisetin 50% (Buxus microphylla Sieb (stem and leaf)), Vitamins 1.6-2.4 mg. Alpha lipoic acid, 8-12 mg; Coenzyme Q-10, 4-6 mg: Betaine HC1, 3.2–4.8 mg: Sulfur (from Vitamin A (as retinyl palmitate and 85% from natural 1400 IU 55 methylsulfonylmethane), 1-1.5 mg. L-Carnitine tartrate, mixed carotenoids) Vitamin C (as aScorbic acid and ascorbyl palmitate) 200 mg 8-12 mg; and L-Carnitine HCl, 4-6 mg: Vitamin D (as cholecalciferol) 30 IU (c) a free radical scavenger complex comprising: Vitamin E (as d-alpha-tocopheryl Succinate and from 40 IU Green tea leaf extract (40% catechin and polyphenols), mixed natural tocopherols) Vitamin K (as phytonadione) 75 mcg 40-60 mg. Anthocyanins (from bilberry fruit and grape Thiamin (as thiamin HCI) 2.5 mg 60 skin extracts), 4-6 mg; Ginkgo biloba leaf extract (24% Riboflavin (as riboflavin and riboflavin-5-phosphate) 5 mg ginkgo flavonglycosides, 6% sesquiterpene lactones), Niacin (as niacinamide and niacin) 70 mg 40-60 mg; and Green barley grass (aerial parts), 20-30 Vitamin B (as pyridoxine HCl and pyridoxal-5-phosphate) 7.5 mg ng Folate (as folic acid) 80 mcg Vitamin B2 (as cyanocobalamin) 120 mcg (d) a DNA repair complex comprising: Biotin 40 mcg 65 Water extract of Uncaria tomentosa (containing carboxy Pantothenic acid (as D-calcium pantothenate) 20 mg alkyl esters), 100-150 mg; N-acetyl-cysteine, 10-15 mg: and Inositol hexaphosphate, 1.6-2.4 mg. US 8,747,915 B1 11 12 (e) a stem cell maintenance complex comprising: Betaine (as betaine-HCl, 2-3 mg: Sulfur (from methyl Chlorella algae, 20-30 mg: Spirulina algae, 40-60 mg: sulfonylmethane), 0.8-1.2 mg; L-Carnitine tartrate, 8-12 Klamath blue-green algae, 60-90 mg: fucoxanthin-con mg; and Acetyl-L-Carnitine HCl, 4-6 mg: taining seaweed (whole plant), 20-30 mg; and Nori sea (c) a free radical scavenger complex comprising: weed extract, 1.6-2.4 mg: Cruciferous vegetable concentrate (broccoli, kale, radish) (f) a cell regulation complex comprising: (2% glucosinolates),32-48 mg: Grape skin extract (37% Gotu kola leaf, 8-12 mg. Phosphatidylcholine (from soy total phenolics), 16-24 mg. Tomato lycopene extract lecithin), 20-30 mg. dimethylaminoethanol (DMAE) (20% lycopene), 1.6-2.4 mg. Rosemary extract (aerial bitartrate, 20-30 mg; Cordyceps sinensis mushroom parts), 2.6-3.9 mg. Pycnogenol (pine bark extract), 1.32 extract (1% cordyceptic acid), 10-15 mg: Royal jelly 3x 10 1.98 mg; Lutein (from marigold flower extract), 0.64 (5%. 10-hydroxy-2-decenoic acid), 8-12 mg: 0.96 mg; and Green barley grass, 8-12 mg: L-Glutamine, 40-60 mg; Taurine, 20-30 mg; L-Pheny (d) a DNA repair complex comprising: lalanine, 20-30 mg. L-Tyrosine, 20-30 mg; Guarana Water extract of Uncaria tomentosa (containing carboxy seed extract (20% caffeine), 32-48 mg; Amylase, 480 alkyl esters), 100-150 mg: Inositol hexaphosphate, 1.6- 720 units; Neutral protease, 120-180 units: Cellulase, 15 2.4 mg. N-acetyl cysteine, 6.4-9.6 mg; and Melatonin, 4-6 units; Lactase, 80-120 units; and Lipase, 2.6-3.9 0.4–0.6 mg units; (e) a stem cell maintenance complex comprising: (g) a group of vitamins comprising: Chlorella algae, 20-30 mg. Spirulina algae, 12-18 mg: Vitamin A (as retinyl palmitate and 85% as beta-carotene), Klamath bluegreen algae, 36-54 mg. Fucoxanthin-con 1,440-2,160 IU; Vitamin C (as ascorbyl palmitate and taining seaweed (whole plant), 20-30 mg; and Brown ascorbic acid), 80-120 mg; Vitamin D (as cholecalcif seaweed extract, 4-6 mg: erol), 32-48 IU; Vitamin E (as d-alpha tocopheryl suc (f) a cell regulation complex comprising: cinate and from mixed natural tocopherols), 40-60 IU: Phosphatidylcholine (from soy lecithin), 16-24 mg: Vitamin K (as phytonadione), 60-90 mcg: Thiamin (as Cordyceps sinensis mushroom extract (1% cordycepic thiamin HCl), 4-6 mg: Riboflavin (as riboflavin and 25 acid), 6.6-9.9 mg: Royal jelly 3x (5% 10-hydroxy-2- riboflavin-5-phosphate), 3.2–4.8 mg; Niacin (as niacina decenoic acid), 7.2-10.8 mg; Inositol, 40-60 mg: mide and niacin), 56-84 mg. Vitamin B6 (as pyridoxine L-Glutamine, 200-300 mg. L-Arginine (as L-arginine HCl and pyridoxal 5-phosphate), 9.6-14.4 mg. Folate (as HCl), 128-192 mg: L-Ornithine (as L-ornithine HCl), folic acid), 40-60 mcg; Vitamin B12 (as cyanocobal 96-144 mg. Taurine, 12.8-19.2 mg. L-Tyrosine, 16-24 amin), 64-96 mcg; Biotin, 40-60 mcg; and Pantothenic 30 mg. Probiotic blend including Lactobacillus acidophi acid (as D-calcium pantothenate), 9.6-14.4 mg; and lus, Lactobacillus plantarum, Bifidobacterium bifidum (h) a group of minerals comprising: and Lactobacillus casei, 40-60 million CFU; Amylase, Iodine (as potassium iodide and from kelp), 24-36 mcg: 320-480 units; Neutral protease, 80-120 units: Lactase, Calcium (as calcium carbonate and citrate), 240-360 52-78 units; and Lipase, 12.8-19.2 units: mg; Zinc (as Zinc glycinate), 1.6-2.4 mg. Selenium (as 35 (g) a group of vitamins comprising: Selenomethionine), 24-36 mcg: Copper (as copper lysi Vitamin A (as retinyl palmitate and 85% from natural nate), 0.16-0.24 mg. Manganese (as manganese glucon mixed carotenoids), 1,120-1,680 IU; Vitamin C (as ate), 0.16-0.24 mg. Chromium (as chromium polynico ascorbic acid and ascorbyl palmitate), 160-240 mg: tinate), 40-60 mcg; and Molybdenum (as sodium Vitamin D (as cholecalciferol), 24-36 IU; Vitamin E (as molybdate), 6.4-9.6 mg; and 40 d-alpha-tocopheryl Succinate and from mixed natural (ii) a second dietary supplement composition for oral tocopherols), 32-48 IU; Vitamin K (as phytonadione), administration in the evening, said second composition 60-90 mcg: Thiamin (as thiamin HCl), 2-3 mg: Ribofla comprising: Vin (as riboflavin and riboflavin-5-phosphate), 4-6 mg: (a) a telomere maintenance complex comprising: Niacin (as niacinamide and niacin), 56-84 mg; Vitamin Purslane extract (aerial parts), 4-6 mg: Turmeric rhizome 45 B6 (as pyridoxine HC1 and pyridoxal-5-phosphate), 6-9 extract (95% curcuminoids), 20-30 mg; Quercetin dehy mg; Folate (as folic acid), 64-96 mcg; Vitamin B12 (as drate, 12-18 mg; Cayenne pepper fruit, 8-12 mg; Vana cyanocobalamin). 96-144 mcg: Biotin, 32-48 mcg; and dium (as Vanadyl sulfate), 16-24 mcg: Fenugreek seed, Pantothenic acid (as D-calcium pantothenate), 16-24 16-24 mg. Valerian root extract, 24-36 mg; and Omega mg; and fatty acid complex, 160-240 mg, including linoleic acid 50 (h) a group of minerals comprising: (10.6%), alpha-linolenic acid (1.3%), oleic acid (1.6%), Iodine (as potassium iodide and from kelp), 9.6-14.4 mcg: borage seed oil (10% gamma-linolenic acid (GLA)), Magnesium (as magnesium oxide and glycinate), 106 evening primrose oil (4.8% GLA); and fish body oil 159 mg; Zinc (as Zinc glycinate), 1.2-1.8 mg: Selenium (4.5% eicosapentaenoic acid, 3.0% docosahexaenoic (as selenomethionine), 19.2-28.8 mcg; Copper (as cop acid); 55 per lysinate), 0.08-0.12 mg. Manganese (as manganese (b) a calorie restriction mimetics and gene expression com gluconate), 0.08-0.12 mg: Chromium (as chromium plex comprising: polynicotinate), 32-48 mcg; and Molybdenum (as Resveratrol (as Polygonum cuspidatum root extract), 1.6- Sodium molybdate), 6.4-9.6 mcg, wherein each compo 2.4 mg. Pterostilbene, 1.6-2.4 mg. Fisetin 50% (Buxus nent is defined in an amount of per serving of each of microphylla Sieb (stem and leaf)), 1.6-2.4 mg. Alpha 60 said compositions. lipoic acid, 8-12 mg: Coenzyme Q10, 2.8-4.2 mg: