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Highlights of the 2Nd International Symposium on Tribbles and Diseases: Tribbles Tremble in Therapeutics for Immunity, Metabolism, Fundamental Cell Biology and Cancer

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Highlights of the 2Nd International Symposium on Tribbles and Diseases: Tribbles Tremble in Therapeutics for Immunity, Metabolism, Fundamental Cell Biology and Cancer Acta Pharmaceutica Sinica B 2019;9(2):443–454 Chinese Pharmaceutical Association Institute of Materia Medica, Chinese Academy of Medical Sciences Acta Pharmaceutica Sinica B www.elsevier.com/locate/apsb www.sciencedirect.com MEETING REPORT Highlights of the 2nd International Symposium on Tribbles and Diseases: tribbles tremble in therapeutics for immunity, metabolism, fundamental cell biology and cancer Bing Cuia, Patrick A. Eyersb, Leonard L. Dobensc, Nguan Soon Tand,e,f,g, Peter D. Maceh, Wolfgang A. Linki,j,k, Endre Kiss-Tothl, Karen Keeshanm, Takuro Nakamuran, Warren S. Pearo, Yodit Fesehap,q, Jessica Johnstonl, Arkatiz Carracedor,s,t,u, Marcel Scheidelerv,w,x,y, Zabran llyasl, Robert C. Bauerz, Jorge D. Erusalimskyaa, Dominika Grzesikab, Juan Salamanca-Viloriaac,ad, Xiaoxi Lva, Yishi Jinae,KeLia,af, Guillermo Velascoag, Shuang Shanga, Jose M. Lizcanoah, Xiaowei Zhanga, Jichao Zhoua, Jiaojiao Yua, Fang Huaa, Feng Wanga, Shanshan Liua, Jinmei Yua, Zhuowei Hua,n aState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China bDepartment of Biochemistry, Institute of Integrative Biology, University of Liverpool, Liverpool L69 7ZB, UK cDivision of Molecular Biology and Biochemistry, School of Biological Sciences, University of Missouri-Kansas City, Kansas City, MO 64110, USA dSchool of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore eLee Kong Chian School of Medicine, Nanyang Technological University, Singapore 639798, Singapore fInstitute of Molecular and Cell Biology, Singapore 138673, Singapore gKK Women's and Children Hospital, Singapore 229899, Singapore hBiochemistry Department, School of Biomedical Sciences, University of Otago, Dunedin 9054, New Zealand iCentre for Biomedical Research (CBMR), University of Algarve, Campus de Gambelas, Faro 8005-139, Portugal jDepartment of Biomedical Sciences and Medicine, University of Algarve, Faro 8005-139, Portugal kAlgarve Biomedical Center (ABC), University of Algarve, Campus de Gambelas, Faro 8005-139, Portugal lDepartment of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield S10 2RX, UK mPaul O'Gorman Leukaemia Research Centre, Institute of Cancer Sciences, University of Glasgow, Glasgow, Scotland G61 1QH, UK nDivision of Carcinogenesis, The Cancer Institute, Japanese Foundation for Cancer Research, Tokyo 135-8550, Japan oDepartment of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA nCorresponding author. E-mail address: [email protected] (Zhuowei Hu). Peer review under responsibility of Institute of Materia Medica, Chinese Academy of Medical Sciences and Chinese Pharmaceutical Association. https://doi.org/10.1016/j.apsb.2018.12.007 2211-3835 & 2019 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). 444 Bing Cui et al. pCentre de Recherche en Transplantation et Immunologie (ou CRTI), Inserm, Université de Nantes, Nantes, France, CHU Nantes, Nantes, France qInstitut de Transplantation Urologie Néphrologie (ou ITUN), CHU Nantes, Nantes, France rCIC bioGUNE, Bizkaia 48160, Spain sCIBERONC, Madrid 28029, Spain tIkerbasque, Basque Foundation for Science, Bilbao 48080, Spain uBiochemistry and Molecular Biology Department, University of the Basque Country (UPV/EHU), Bilbao 48080, Spain vInstitute for Diabetes and Cancer IDC, Helmholtz Center Munich, Neuherberg 85764, Germany wJoint Heidelberg-IDC Translational Diabetes Program, University Hospital Heidelberg, Heidelberg 85764, Germany xMolecular Metabolic Control, Medical Faculty, Technical University Munich, Munich 85764, Germany yGerman Center for Diabetes Research (DZD), Neuherberg 85764, Germany zDivision of Cardiology, Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA aaSchool of Sport and Health Sciences, Cardiff Metropolitan University, Cardiff CF5 2YB, UK abCentre for Endocrinology, William Harvey Research Institute, John Vane Science Centre, Queen Mary, University of London, London EC1M 6BQ, UK acIntelligent Pharma-Mind the Byte S.L., Barcelona 08028, Spain adFacultat de Farmàcia, Universitat de Barcelona, Barcelona 08028, Spain aeSection of Neurobiology, Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA afInstitute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100050, China agDepartment of Biochemistry and Molecular Biolgy, School of Biology, Complutense University and Instituto de Investigaciones Sanitarias San Carlos (IdISSC), Madrid 28040, Spain ahDepartment of Biochemistry and Molecular Biology, Institute of Neurosciences, Faculty of Medicine, Universitat Autonoma de Barcelona, Bellaterra 08193, Spain Received 12 July 2018; received in revised form 19 November 2018; accepted 20 November 2018 KEY WORDS Abstract The Tribbles (TRIB) family of pseudokinase proteins has been shown to play key roles in cell cycle, metabolic diseases, chronic inflammatory disease, and cancer development. A better understanding Tribbles; Immunology; of the mechanisms of TRIB pseudokinases could provide new insights for disease development and help Metabolism; promote TRIB proteins as novel therapeutic targets for drug discovery. At the 2nd International Cell biology; Symposium on Tribbles and Diseases held on May 7–9, 2018 in Beijing, China, a group of leading Kinase inhibitor; Tribbles scientists reported their findings and ongoing studies about the effects of the different TRIB Tumorigenesis; proteins in the areas of immunity, metabolism, fundamental cell biology and cancer. Here, we summarize Metastasis; important and insightful overviews from 4 keynote lectures, 13 plenary lectures and 8 short talks that took TRIB1; place during this meeting. These findings may offer new insights for the understanding of the roles of TRIB2; TRIB pseudokinases in the development of various diseases. TRIB3; Pseudokinase; & 2019 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Inflammation; Atomic structure; Sciences. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND Protein quality control; license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Ubiqutin 1. Introduction Recent advancements focused on the roles of TRIBs in immunol- ogy, metabolism, fundamental cell biology and tumorigenesis4–7. The Tribbles (TRIB) pseudokinases control multiple aspects of Emerging evidences indicates that targeting TRIBs might also eukaryotic cell biology and have evolved unique features distin- provide therapeutic opportunity for many different diseases8,9. guishing them from all other eukaryotic protein kinases1. Under- The 2nd International Symposium on Tribbles and Diseases was standing the roles of Tribbles proteins, which include human held between May 7–9, 2018 in Beijing, China. This international TRIB1, TRIB2 and TRIB3, in disease initiation and development meeting was sponsored by the Chinese Academy of Medical Sciences provides better opportunities for targeted-therapies in the future. (CAMS) and State Key Laboratory of Bioactive Substance and Due to the absences of the conserved kinase catalytic domain or Function of Natural Medicines (BSFNM). The organizers invited ATP binding sites, TRIBs are described as pseudokinases2. TRIBs, worldwide scientists who focused on the research of TRIBs protein in as key adaptors, play important roles to regulate several important many different perspectives. The meeting was composed of three signaling pathways and control the quality of many proteins3. major sessions, including “Tribbles and Immunity & Metabolism” Tribbles tremble in therapeutics for immunity, metabolism, fundamental cell biology and cancer 445 chaired by Prof. Warren Pear and Dr. Zhuowei Hu, “Tribbles and He first introduced the in vitro models of EMT from his recent Fundamental Cell Biology” chaired by Dr. Karen Keeshan and Prof. study15, which identified angiopoietin-like 4 (ANGPTL4) as a Takuro Nakamura, and “Tribbles and Cancer” chaired by Prof. key player that coordinates an increase in cellular energy flux Patrick Eyers and Prof. Leonard Dobens. crucial for EMT via an ANGPTL4/14-3-3γ signaling axis The meeting consisted of 4 keynote lectures, 13 plenary lectures (Fig. 1). ANGPTL4, a secreted glycoprotein, binds to specific and 8 short talks. This report summarizes the major highlights integrins, cadherins and claudins, but not Tie receptors and presented at the 2nd International Symposium on Tribbles and VEGFR16. ANGPTL4 was found to protect against severe Diseases. With a focus on the most recent advances in the fields of proinflammatory effects of saturated fats17. Elevated ANGPTL4 immunity, metabolism, fundamental cell biology, and cancer, the expression is found in many cancer subtypes, including breast programs covered a wide range of important topics, including cancer, lung cancer and gastric cancer15,18.Dr.Tandiscussed atherosclerosis, obesity, fibrotic diseases, inflammation, normal how augmented energy charge status enhances metastasis. blood cells differentiation, signaling in Drosophila and Caenor-
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