Geographic Stomatitis Coğrafik Stomatit
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OLGU RAPORU (Case Report) Hacettepe Diş Hekimliği Fakültesi Dergisi Cilt: 32, Sayı: 2, Sayfa: 73-78, 2008 Geographic Stomatitis Coğrafik Stomatit *Nursel AKKAYA DDS, PhD, **Seher KaRagÜL DDS, PhD, *Aydan KanLı DDS, PhD *Hacettepe University, Faculty of Dentistry, Department of Oral Diagnosis and Radiology. **Private Dentist ABSTRACT ÖZET Geographic tongue lesions may also appear, though Coğrafik dil lezyonları oral kavitenin diğer muko- rarely, on other mucosal areas of the oral cavity. This zal bölgelerinde de nadiren görülebilir. Bu durum type of lesion is called as geographic stomatitis. The coğrafik stomatit olarak adlandırılmaktadır. Nedeni cause is unknown; yet, emotional stress, nutritional bilinmemektedir. Ancak emosyonel stres, beslenme deficiencies, and hereditary factors are suggested. bozuklukları ve herediter faktörlerin neden olabile- Clinically, it occurs as red annular patches of the labial ceği ileri sürülmektedir. Klinik olarak labial ya da or buccal mucosa, soft palate; rarely gingiva and floor bukkal mukozada, nadiren gingiva ve ağız tabanında of mouth. There are mild erosions of the mucosa on kırmızı, halka şeklinde yamalar tarzında görülürler. these lesions, which are frequently multiple and well- Sıklıkla çok sayıda ve belirgin sınırları olan bu lezyon circumscribed. Characteristically lesions change their bölgelerinde mukozanın hafif erozyonuna rastlanır. shape and location. The condition is usually asymp- tomatic. When symptomatic, palliative treatment is Karakteristik olarak lezyonlar şekil ve yer değiştirir. recommended. Bu durum genellikle asemptomatiktir. Semptomatik olduğunda palyatif tedavi önerilmektedir. The purpose of the present paper is to report two cases of geographic stomatitis and to discribe a pos- Bu makalenin amacı, iki coğrafik stomatit olgusu sible connection between this condition and patients’ sunmak ve bu durum ile hastanın emosyonel statüsü emotional status. arasındaki olası ilişkiyi tanımlamaktır. KEYWORDS ANAHTAR KELİMELER Geographic stomatitis, migratory stomatitis, stomatitis Coğrafik stomatit, migratuar stomatit, stomatitis areata areata migrans, erythema circinate migrans, ectopic migrans, eritema sirsinate migrans, ektopik coğrafik dil. geographic tongue. These cases were presented in 3. Scientific Symposium of Oral Diagnosis and Dentomaxillofacial Radiology Society, 21-23 April 2006, Kemer, Antalya 74 INTRODUCTION before acquiring the typical appearance of geo- graphic lesion. Geographic tongue is a condition character- ized by atrophy of the filiform papilae on single Type 4: Geographic lesions elsewhere in the or multiple areas of the tongue in an irregular mouth, without the presence of a geographic pattern which is frequently accompanied by pe- tongue. ripheral keratosis. These geographic lesions oc- Although its etiology is unknown, many dif- cur on the dorsum and lateral borders of tongue ferent conditions, such as pustular psoriasis, Re- in about 1–2 % of general population1. Similar iter’s syndrome, atopy, stress may be associated changes may appear on other mucosal areas of with GS. The condition is more common in men the oral cavity. This uncommon condition was than women. No particular age group shows an first described in 1955 under the term “ery- increased tendency to GS7. thema migrans” by Cooke2. It is also named as The purpose of the present paper is to re- migratory stomatitis, stomatitis areata migrans, port two additional cases of GS and to describe a erythema circinate migrans, ectopic geographic possible connection between this condition and tongue, geographic stomatitis, annulus migrans, patients’ emotional status. Cooke’s disease and migratory mucositis3. The most frequently reported sites of geo- CASE 1 graphic stomatitis (GS) are the buccal mucosa, lower labial mucosa and mucobuccal fold. In- 33 year-old woman applied to our clinic for volvement of the gingiva, alveolar mucosa, soft routine dental examination. Her medical his- palate and floor of the mouth is unusual4. tory was unremarkable. Extraoral examination revealed hyperkeratosis on her left hand. There Clinical presentation of GS is described as slightly raised, round, erythematous lesions that were no skin lesions present except the hyper- are circumscribed by well-defined whitish bor- keratosis of hand. Intraoral examination showed ders. The lesions vary in size from a few millime- multiple erythematous lesions surrounded by a ters to several centimeters in diameter5. narrow white margin on the right buccal muco- sa, mucobuccal fold, the right upper labial mu- Hume6 has made a classification of GS based cosa and the dorsum of the tongue (Figure 1–3). on its clinical distribution: The lesions varied in size and had well-defined, Type 1: Lesions on the dorsum, lateral bor- white, slightly raised, circinate borders. No evi- ders and tip of tongue with possible extension dence of vesicle formation was noted. There was to undersurface. The lesions may migrate with fissuring of the dorsum of the tongue. She was time and show both active and remission phases unaware of mucosal lesions but she was suffering (geographic tongue, without geographic lesions from burning of tongue after consuming hot or elsewhere in the mouth). spicy foods. Patient expressed that she has been Type 2: Geographic tongue, accompanied by under stressful condition during the last three geographic lesions elsewhere in the mouth. months because of her mother’s health problems Type 3: Atypical tongue lesions whether or and intensity of symptoms has increased during not accompanied by lesions elsewhere in the this period. Patient was referred to Dermatology mouth. Atypical tongue lesions consist of two Clinic for the evaluation of lesions on her hand forms: A- Fixed forms; one or two areas of tongue and possible relationship between skin and oral are affected but movement is not observed. In- mucosal lesions. Skin lesions of her hand were stead, they disappear only to recur after a pe- diagnosed as “contact dermatitis”. Therefore, it riod of time at the same area. B- Abortive forms; was concluded that skin and oral mucosal lesions these start as yellow-white patches but disappear were not related. 75 FIGURE 3 Deep grooves and fissures on the dorsum of the tongue accompanied by geographic lesions in Case 1. Oral lichen planus and acute atrophic candidia- FIGURE 1 sis were considered as differential diagnoses. Multiple, well-demarcated erythematous lesions of geographic Lichen planus could be excluded as the clinical stomatitis on the maxillary labial mucosa in Case 1. appearance was not consistent with this condi- tion. A smear from the lesions of oral mucosa for the evaluation of oral candidiasis was nega- tive. Her dermatologist decided to take biopsy, but the mucosal lesions disappeared on appoint- ment day. However, no scars were left at the sites of the previous lesions. An incisional biopsy was performed for tongue lesions. Microscopic examination of the biopsy specimen showed acanthosis in the surface epitelial layer, subepi- thelial neutrophil infiltrates and the formation of microabscesses and chronic inflammatory infil- trate in submucosa. Microscopic diagnosis was “geographic tongue”. Benzydamin HCl and tri- amcinolone acetonide were used for symptomat- ic treatment. We offered to avoid topical factors that exacerbate her symptoms, such as very hot, spicy, or acidic foods. A two weeks follow-up conducted with the patient revealed only the mi- FIGURE 2 gratory behavior of these asymptomatic lesions. Involvement of the mandibular mucobuccal fold with discrete, The clinical diagnosis of geographic stomatitis annular lesions in Case 1. was made. 76 CASE 2 sions were migrating, they were similar in sight. Due to all these characteristic attributions, no 43 year-old man had applied to our clinic biopsy was taken and the disease diagnosed as for toothache. In his medical history, patient ex- “geographic stomatitis”. Nonetheless, the patient pressed that he has been under medical treat- was directed to internal medicine department. ment until he was 19 years old, due to congenital Due to detection of hypercalsuri in urinalysis hypothyroidism. Currently he is not using any examination the patient is directed to urology medication. He has been undergoing psychologi- department. In his abdomen CT and renal USI, cal treatment since 1993 because of over ner- renal cortical cysts were seen in both of his kid- vousness, instability to control himself and prob- neys. Suspected of internal hernia in the right lematic relations in the working environment. hemi region of the abdomen, radiology depart- Extraoral examination was unremarkable. ment requested intestinal passage examination. During intraoral examination it was detected that Results were normal. he had fissured tongue and there were bilater- Patient monitored for a year with regular ally, slightly raised, erythematous lesions on the periods. It was observed that the intensity and buccal mucosa (Figure 4). The lesions had white, localization of the lesions changed and this situa- circinate borders. In these regions, there was no tion was attributed to his emotional stress. symptom in the burning or pain characteristics. Also the patient expressed that he was unaware DISCUSSION of this condition. Result of the smear taken from the lesion region in order to detect possible exis- In the literature limited numbers of GS cases tence of candida albicans showed normal flora. were reported, however some of the researchers Full blood test results, vitamin B12 and folate lev-