antioxidants Article Green-Sustainable Recovery of Phenolic and Antioxidant Compounds from Industrial Chestnut Shells Using Ultrasound-Assisted Extraction: Optimization and Evaluation of Biological Activities In Vitro 1,2, 1, 1 3 3 Fátima Lameirão y, Diana Pinto y, Elsa F. Vieira , Andreia F. Peixoto , Cristina Freire , Stefania Sut 4, Stefano Dall’Acqua 4,5 , Paulo Costa 2 , Cristina Delerue-Matos 1 and Francisca Rodrigues 1,* 1 Polytechnic of Porto—School of Engineering, REQUIMTE/LAQV, Rua Dr. António Bernardino de Almeida, 4249-015 Porto, Portugal;
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[email protected] (C.D.-M.) 2 REQUIMTE/UCIBIO, MedTech-Laboratory of Pharmaceutical Technology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira nº. 228, 4050-313 Porto, Portugal; pccosta@ff.up.pt 3 REQUIMTE/LAQV, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Rua do Campo Alegre 1021/1055, 4169-007 Porto, Portugal;
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[email protected] (C.F.) 4 DAFNAE, Department of Agronomy, Food, Natural Resources, Animals and Environment, University of Padova, Viale dell’Università, 16, Legnaro, PD 35020, Italy;
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[email protected] (S.D.) 5 DSF, Department of Pharmaceutical and Pharmacological Sciences, University of Padova, via Marzolo 5, 35121 Padova, Italy * Correspondence:
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[email protected]; Tel.: +351-22-83-40-500; Fax: +351-22-83-21-159 The authors contributed equally to the present work.