Graduate School of Biomedical Sciences

32nd Annual Student Research Week March 10-13, 2020 Texas Tech University Health Sciences Center (TTUHSC) Lubbock, Texas

The Graduate School of Biomedical Sciences 2020 Student Research Week Committee

Director: Bradley Schniers Vice Director of Marketing: Mariacristina Mazzitelli Vice Director of Poster Competition: Rachel Washburn Vice Director of Operations & Judging: Ryan Sweazey

Website design and maintenance: Danny Boren, Graduate School of Biomedical Sciences Communications and social media: Suzanna Cisneros and Amy Skousen, Office of Communications Marketing; Leslie Fowler, Graduate School of Biomedical Sciences Speaker travel arrangements: Leslie Fowler, Graduate School of Biomedical Sciences Abstract book design: Deidra Satterwhite, Office of Student Life Student Research Week Banquet: Korac K, Graduate School of Biomedical Sciences Graduate Student Association; Velia Martinez, Graduate School of Biomedical Sciences

The 2020 Student Research Week Committee would like to extend their warmest thanks to the following for their contributions and support in making Student Research Week a great success this year:

The Graduate School of Biomedical Sciences staff: Leslie Fowler, Pam Johnson, Ashlee Rigsby and Velia Martinez The Office of Student Life: Deidra Satterwhite The Office of Communications and Marketing: Suzanna Cisneros, Amy Skousen and Kami Hunt The Office of the President: Bryce Looney The School of Medicine Office of the Dean: Charity Donaldson Educational Media Services: Neal Hinkle The departments of cell biology and biochemistry, pharmacology and neuroscience, immunology and molecular microbiology, cell physiology and molecular biophysics, medical education and graduate medical education; Graduate School of Biomedical Sciences at Lubbock, Abilene, and Amarillo, the School of Medicine, the School of Nursing, the School of Health Professions, the School of Pharmacy, the Office of Interprofessional Education, and Texas Tech University.

Lou Diekemper Endowment fund for providing a travel scholarship. Dr. Beverly Chilton for establishing the Bette B. Chilton scholarship in honor of her mother.

We also are very grateful to all the TTUHSC faculty and staff for their guidance and support.

TTUHSC Signature, TTUHSC Graduate School of Biomedical Sciences Signature and TTUHSC Graduate Student Association Signature are trademarks of the Texas Tech University System and the TTUHSC. Information about the TTUHSC Identity Guidelines can be found at www.ttuhsc.edu.

Information about TTUHSC, including information about the Graduate School of Biomedical Sciences, can be found at www.ttuhsc.edu. Friday, March 13, 2020 KEYNOTE LECTURES

Ernest Marshall Wright, Ph.D., D.Sc.

Time: 11:15 a.m. - 12:15 p.m. Maralice Conacci-Sorrell, Ph.D.

Time: 1:15 - 2:15 p.m.

STUDENT SPEAKERS Time: 9 - 11 a.m.

Using Formative Exams in Clinically Oriented Anatomy: Identifying At-Risk Students and Reducing Stress Megh Gore, Graduate Student, Lubbock

A Novel Mechanism of Assembly in the Functional CRES Amyloid Rebecca Kusko, Medical Student, Lubbock

Endothelial small GTPase RhoA regulates bFGF-induced angiogenesis: A potential target for anti-angiogenic therapy Fatema Tuz Zahra, Graduate Student, Amarillo

Mechanism of Antimony Drug Resistance in Leishmania Parasites Sneider Gutierrez, visiting Graduate Student, Lubbock

Progesterone Receptor Membrane Component 1 communicates with classical steroid hormone signaling to promote breast cancer growth Diego Pedroza, Graduate Student, El Paso

Multi-color immunophenotyping of M1 and M2 polarized macrophages and mono- cytes in primary mouse tissue that has vast application in mouse models including transplantation Kandis Wright, Medical Student, Lubbock

Acetylation of conserved DVL-1 lysines regulates its nuclear translocation and binding to gene promoters in triple-negative breast cancer Monica Sharma, Graduate Student, Lubbock

Pancreatic tumor growth suppression through induction of autophagy by a novel anti- Parkinson drug Pimavanserin Sharavan Ramachandran, Graduate Student, Abilene TABLE OF CONTENTS

6 Welcome 9 Schedule of Events

10 Speaker Biographies

POSTER SESSIONS 12 List of Judges 14 Judging Criteria 16 Index of Abstracts List 18 Judging Schedule

ABSTRACTS 22 Graduate Students - 1st & 2nd Years 30 Graduate Students - 3 Years +

43 Phamarceutical Sciences | Pharmacy

49 Medical Students 1st & 2nd Years | GMS | PH

102 Medical Students 3rd & 4th Years

128 School of Nursing

130 Residents & Clinical Fellows

140 School of Health Professions 145 Undergraduate

INFORMATION 153 Poster Regulations

155 Parking Information 157 Community Sponsor Back Cover Vendors

5 WELCOME Greetings!

It is my great pleasure to welcome everyone to the 2020 Student Research Week on March 10th-13th. The theme for this year’s 32nd Annual Student Research Week event is “SRW 2020: Visions of Biochemistry.” We are extremely proud this year to host two outstanding and highly distinguished keynote speakers: Dr. Ernest Wright, DSc, professor of physiology and Mellinkoff Professor in Medicine at the David Geffen School of Medicine at UCLA, and 2005 Fellow to the Royal Society; and Dr. Maralice Conacci-Sorrell PhD, Virginia Murchison Linthicum Scholar in Medical Research and Professor in the Department of Cell Biology at University of Texas Southwestern.

I am extremely indebted to the 2019 Student Research Week Organizing Committee: Bradley Schniers (Director), Mariacristina Mazzitelli (Director of Marketing), Ryan Sweazey (Director of Operations), Rachel Washburn (Poster Competition Coordinator), Ksenija Korac (GSA President) and Morgana Kellogg (GSA Vice-President). They have all done a tremendous job! I am particularly grateful for the hard work and assistance from Leslie Fowler, Pam Johnson, Deidra Satterwhite, Amy Skousen, Sharla Cook, Nerissa Farris, the Department of Cell Biology & Biochemistry, and the entire GSBS staff. They have all done a terrific job! Also special thanks to Dr. Ganapathy, the host department chair, and Dr. Betsy Jones for coordinating activities with the School of Medicine, all faculty, staff, and GSBS students for their efforts and time. Finally, I would like to thank Interim President Lori Rice-Spearman, Dean Berk, Dean Evans, Dean Smith, and Drs. Varma, Prien, Sizer, Grisham, Altenberg, Byrd, Philips, Thekkumkara, Neugebauer, Abbruscato, Dissanaike, Jumper, Srivastava, and Bergeson for their support that has made this event possible.

In addition, the GSBS and the GSA are very excited about hosting the seventh annual Student Research Week Banquet- Roaring 20’s. Funds raised from donations and a silent auction will be used to support student scholarships. Special thanks to all donors for their help in making this special event possible. Our guest speakers will once again treat us with their “Reflections on Graduate Studies,” with music, entertainment and dancing to follow! Special thanks to the GSA committee, especially GSA president Ksenija Korac, for organizing and hosting the event this year.

In conclusion, our event kicks off with the Vendor Show and Career Fair on Tuesday, March 10th. Please come and attend all the great presentations. It is a wonderful opportunity to meet our students, learn about their work, and discuss research in general. Let’s greet all of our speakers and celebrate our 32nd Annual Student Research Week with a fully packed lecture hall. Thanks much and all the best!

Brandt L. Schneider, Ph.D.

Dean of the Graduate School of Biomedical Sciences

6 Welcome!

On behalf of the Student Research Week (SRW) committee, we’d like to welcome you to the 32nd annual Student Re- WELCOME search Week 2020: “Visions of Biochemistry”. This is an annual event organized by the Texas Tech University Health Sciences (TTUHSC) Graduate School of Biomedical Science (GSBS), Lubbock Campus. SRW is an incredible event that brings together students from different TTU and TTUHSC schools and campuses; giving them the opportunity to present their research, win awards, and meet with keynote speakers throughout the week. During SRW, students have the opportunity to visit with biomedical vendors, present a poster detailing their research, and learn about scientific discover- ies from distinguished visiting keynote speakers.

Each year, SRW features a new theme highlighting advances in various areas of biomedical research. This year’s theme is “SRW 2020: Visions of Biochemistry” and is hosted by the Department of Cell Biology and Biochemistry. Two outstand- ing biomedical scientists will give keynote addresses on Friday, March 13th, highlighting their research in the field of Cell Biology and Biochemistry. Ernest Wright, D.Sc., is a professor of physiology and Mellinkoff Professor in Medicine at the David Geffen School of Medicine at UCLA, and also a Fellow to the Royal Society. Wright, a native of Belfast, Ireland, earned his doctorate degrees in physiology from London University and Sheffield University in England. He joined the faculty at the UCLA medical school in 1967, and became chair of the physiology department in 1987. In his research over transporters and kidney function, Wright’s career in science has yielded several important discoveries over SLGT transporters, the SLC5A family of transporters, as well as the structure and function of other transporters. Maralice Conacci-Sorrell, Ph.D., earned her B.S in Biology, and a master’s degree in Morphology from the University of Sao Paulo in Brazil, followed by graduate studies in Cell Biology at the Weizmann Institute of Science in Israel. Conaci-Sorrell is very dedicated to research in her role as the Virginia Murchison Linthicum Scholar in Medical Research within the De- partment of Cell Biology at the University of Texas Southwestern. Her current research looks to understand the funda- mental functions of Myc in cancer cell biology. In addition, it explores the role of protein acetylation as a key coordinator of cancer cell survival and migration. These scientists are outstanding researchers and we encourage everyone to attend their seminars Friday, followed by the poster awards ceremony and Coffee with the Speakers.

The SRW poster competition, starting the afternoon of Tuesday, March 10th, gives students the opportunity to present their research and view the research of other students in a conference-like atmosphere. There will be students from all TTU and TTUHSC campuses, with over 250 students presenting their research this year. We would like to invite every- one to attend the open poster sessions from 12-1pm Tuesday through Thursday in the Academic Event Center to learn about ongoing student research projects.

SRW would not be possible without the tireless and dedicated efforts of numerous people working to make it the suc- cess it is. We would like to thank the faculty and staff of the GSBS, the Offices of Student Services and Marketing and Communications, the School of Medicine, and the Department of Cell Biology and Biochemistry. We would also like to thank interim President Rice-Spearman and Drs. Scheider, Prien, Ganapathy, Berk, Varma, Ashcraft, and Jones. Lastly, we’d like to thank all of the participants in the 32nd annual Student Research Week, whose ideas and shared research are what make this such a successful event each year.

Sincerely, The 32nd Annual Student Research Week Committee

Bradley Schniers, Mariacristina Mazzitelli, Rachel Washburn, Ryan Sweazey

7 8 32ND ANNUAL TTUHSC STUDENT RESEARCH WEEK SCHEDULE

TUESDAY, MARCH 10, 2020

9:00am - 3:00pm Vendor Show ACB Lobby

12:00pm - 1:00pm Open Poster Exhibit I Academic Event Center SCHEDULE

1:00pm - 4:00pm Poster Session I Academic Event Center

WEDNESDAY, MARCH 11, 2020

8:30am - 12:00pm Poster Session II Academic Event Center

12:00pm - 1:00pm Open Poster Exhibit II Academic Event Center

1:00pm - 4:00pm Poster Session III Academic Event Center

THURSDAY, MARCH 12, 2020

8:30am - 12:00pm Poster Session IV Academic Event Center

12:00pm - 1:00pm Open Poster Exhibit III Academic Event Center

1:00pm - 4:00pm Poster Session V Academic Event Center

6:00pm SRW Banquet McKenzie-Merket Alumni Center

FRIDAY, MARCH 13, 2020

8:00am - 8:45am Continental Breakfast ACB Lobby

9:00am - 11:00am Select Student Presentations Academic Event Center

11:15am - 12:15pm Maralice Conacci-Sorrell, Ph.D. Academic Event Center

12:15pm - 1:15pm Lunch & Case Study Academic Event Center

1:15pm - 2:15pm Ernest Wright, D.SC. Academic Event Center

2:15pm - 3:15pm Awards Ceremony Academic Event Center

3:15pm - 4:15pm Students’ Coffee with the Speakers Academic Event Center

9 SPEAKERS SPEAKERS

Maralice Conacci-Sorrell, Ph.D. Virginia Murchison Linthicum Scholar, Professor, University of Texas Southwestern

Dr. Maralice Conacci-Sorrell’s academic training encompasses multiple fields ranging from Envi- ronmental Biology to Medical Sciences. She received a B.S. in Biology, and a master’s degree in Morphology (human anatomy, histology, developmental biology, and cell biology) from the Uni- versity of Sao Paulo in Brazil.

To pursue graduate studies in Cell Biology, Dr. Conacci-Sorrell joined the lab of Dr. Avri Ben-Ze’ev in the Department of Cellular and Molecular Biology at the Weizmann Institute of Science in Israel. There, my work focused on the interplay between Wnt signaling and cell-cell adhesion. Her work was among the first to address the mechanisms of tumor cell proliferation and metastasis induced by oncogenic beta-catenin. Together her studies contributed to our understanding of how cell-cell adhesion regulates the Wnt pathway, and in turn, how the Wnt pathway controls the expression of adhesion molecules.

With the goal of identifying a common signature employed by different oncogenes in order to drive tumorigenesis, Dr. Conacci-Sorrell received an EMBO fellowship and joined the lab of Dr. Robert Eisenman at the Fred Hutchinson Cancer Research Center for her postdoctoral studies. There she discovered a new pathway for regulating Myc levels and function in normal and in cancer cells. She- found that Myc proteins are targeted by calcium-dependent calpain proteases, which convert Myc into a cytoplasmically active protein, that she named Myc-nick. In 2013, this work was recognized with the Darrel Goll award at the FASEB meeting “The biology of Calpains in health and disease”. Her subsequent research showed that Myc-nick is highly expressed in cancer cells, where it appears to drive tumor progression by promoting both survival and motility in response to metabolic stress.

10 SPEAKERS

Ernest Marshall Wright, Ph.D., D.Sc. Professor, UCLA, School of Medicine

Ernest Wright, professor of physiology and Mellinkoff Professor in Medicine at the David Gef- fen School of Medicine at UCLA, has been named a 2005 Fellow to the Royal Society, an honor considered one of the highest accolades a scientist can achieve next to the Nobel Prize. Born in Belfast, Ireland, Wright joined the faculty of the medical school in 1967, and was tapped to chair the physiology department in 1987. His research focuses on the structure, function and genetics of transport proteins, which act as gatekeepers for the body by carrying essential molecules in and out of cells. In 2003, his research team identified a new protein that senses changes in glucose, the blood sugar that fuels body function. The UCLA discovery could lead to the development of new drugs to control diabetes and obesity. I n his 38-year tenure at UCLA, Wright has mentored more than 40 postdoctoral fellows and graduate students. During his career, he received the Senator Jacob K. Ja- vits Neuroscience Investigator Award from the National Institutes of Health from 1985 to 1992, and was named the Walter B. Cannon Distinguished Lecturer by the American Physiological Society in 1989, the G.W. Harris Lecturer by the British Physiological Society in 1990 and a Fellow of the Biophysical Society in 2005. He has served on the editorial boards for several physiology journals, consults for the National Institutes of Health, and is a scientific advisor to the Eli and Edythe L. Broad Medical Foundation in Los Angeles. Wright earned his doctorate degrees in physiology from London University and Sheffield University in England, and conducted his research fellowship at Harvard University in Boston.

11 Andrey Karamyshev, Ph.D. Karamyshev, Andrey BiologyCell and Biochemistry Ph.D. Keyel, Michelle BiologyCell and Biochemistry Petar Grozdanov, Ph.D. Grozdanov, Petar Biotechnology DVM Ph.D., Guindon, Josee Pharmacology and Neuroscience Ph.D. Hamood, Abdul Immunology Microbiology and Molecular Ph.D. I. Henderson, George Pharmacology and Neuroscience Ph.D. Hewetson, Aveline BiologyCell and Biochemistry Ph.D. Janovick, Jody BiologyCell and Biochemistry M.D., M.P.H. Jumper, Cynthia Health Public Kang, PharmD Min Pediatrics John W. Culberson, M.D. Culberson, W. John Community Medicine and Family Deshmukh Hemalata Ph.D. Do, Qyunh Hoa PhysiologyCell Biophysics and Molecular Ph.D. Dufour, Jannette BiologyCell and Biochemistry Ph.D. Anna Eiring, Medicine Translational and Molecular Ph.D. Fleming, Derek Immunology Microbiology and Molecular M.D. Griswold, John Surgery

Gail Cornwall, Ph.D. Cornwall, Gail BiologyCell and Biochemistry Jane Colmer-Hamood, Ph.D. Colmer-Hamood, Jane Education Medical Isabel Castro, Ph.D. Castro, Isabel Immunology Microbiology and Molecular Theresa Byrd, DrPH Byrd, Theresa Health Public Greg Brower, Ph.D., DVM Ph.D., Brower, Greg Education Medical Jean-Michel Brismeé, ScD Brismeé, Jean-Michel Therapy Physical Ion Alexandru Bobulescu, M.D. Ion BiologyCell and Biochemistry Michael Blanton, Ph.D. Blanton, Michael Pharmacology and Neurocience Keith Bishop, Ph.D. Bishop, Keith Education Medical Yangzom D. Bhutia, Ph.D., D.V.M. Ph.D., D. Bhutia, Yangzom BiologyCell and Biochemistry Kishor Bhende, M.D. Kishor Bhende, Pediatrics Susan Bergeson, Ph.D. Susan Pharmacology and Neuroscience Jeremy Bailoo, Ph.D. Bailoo, Jeremy Pharmacology and Neuroscience Emily Bailey Bailey Emily Health Public Duke Appiah, Ph.D. Appiah, Duke Health Public Sandhya Annamaneni Sandhya Pharmaceutical Sciences Pradeepkiran Jangampalli Adi, Ph.D. Adi, Jangampalli Pradeepkiran Medicine Internal JUDGES

JUDGINGJUDGES 12 Immunology andMicrobiology Immunology Kevin Pruitt, Ph.D. andNeuroscience Pharmacology Lisa Popp, Ph.D. andMolecular Biophysics Cell Physiology Girijesh KPatel andMolecular Biophysics Cell Physiology Hariharan Parameswaran, Ph.D. andBiochemistry Cell Biology Kumar Palle, Ph.D. andNeuroscience Pharmacology Madhusudhanan Narasimhan, Ph.D. andNeuroscience Pharmacology Srinivas Nandana, Ph.D. Internal Medicine Adebayo Molehin, Ph.D. andMolecular Biophysics Cell Physiology Martinez-Zaguilan,Raul Ph.D. andBiochemistry Cell Biology Chinnadurai Mani andBiochemistry Cell Biology Clinton MacDonald, Ph.D. andMolecular Biophysics Cell Physiology Hongjun (Henry) Liang,Ph.D. andNeuroscience Pharmacology Josh Lawrence, Ph.D. Garrison Institute onAging Subodh Kumar, Ph.D. Sudhir Kshirsagar Medical Education Cassie Ph.D., Kruczek, M.S. Public Health HafizKhan, Ph.D. Cell Biology andBiochemistry Cell Biology Devaraja Rajasekaran Manisha Tripathi,Ph.D. andBiochemistry Cell Biology Elena Tikhonova,Ph.D. Graduate Medical Sciences,Strategic Partnerships Annette Sobel, M.D.,M.S. Research Commercialization Cameron Smith, J.D.,CLP Psychiatry Sarangi,Ashish MD Surgery Kendra Rumbaugh, Ph.D. Internal Medicine Bhagavathi Ph.D. Ramasubramanian, andBiochemistry Cell Biology Sabarish Ph.D. Ramachandran, Surgery Hannah Zhao-Fleming Public Health Margaret Vugrin,MPH Garrison Institute onAging MuraliPh.D. Vijayan, andNeuroscience Pharmacology 13 JUDGINGJUDGES CRITERIA FOR CASE PRESENTATIONS

ANALYSIS/SYNTHESIS: 1. Includes data from 4 or more sources (explicity stated in the case study) 2. Reveals student’s strengths, weaknesses, etc. JUDGING DIAGNOSIS: 1. Detailed description of consistencies or patterns leading to summary of the problem or situation. 2. Describes possible causes. 3. Includes other significant characteristics of the student. INTERVENTIONS: 1. Includes five to six sessions. 2. Detailed summary of strategies and techniques used. 3. Strong plan. EVALUATION: 1. Detailed summary of results. 2. Includes strong pre- and post-test evidence. 3. Includes decision for termination or referral. REFLECTION: 1. Thoughtful description of the experience, the challenges, and the successes. MICELLANCEOUS: 1. Text is well written. 2. Sections are labeled. 3. Minimal grammar or spelling errors.

14 CRITERIA FOR SCIENTIFIC RESEARCH

SIGNIFICANCE/ INTRODUCTION: 1. Significance of the work and why it is important to conduct this research is addressed. 2. Background information is clearly presented. 3. Hypothesis is clearly stated. (for science categories only)

ORGANIZATION JUDGING 1. Methods utilized are clearly explained. 2. Presentation is well organized. 3. Student shows knowledge of the subject. RESULTS: 1. Tables or graphs are used to enhance the presentation. 2. Presenter explains the figures and results. 3. Figures are appropriately formatted and clearly understood. DISCUSSION/CONCLUSIONS: 1. Presenter summarizes findings clearly. 2. Presenter clearly explains what the findings mean and their significance. 3. Directions for future investigation or management of similar cases are indicated/discussed. PRESENTATION /RESPONSE TO QUESTIONS: 1. Overall style of the presentation is effective (delivery/eye contact). 2. Presenter uses time effectively. 3. Presenter answers questions in an organized, concise, and accurate fashion. COMMERCIALIZATION (IF APPLICABLE): 1. Presenter states how their research impacts the world. 2. Presenter states how the research could be a product. 3. Presenter states steps they would take to pursue commercialization.

15 MS1-2 George, Asher MS1-2 George, Megh MS1-2 Gore, Derrick MS1-2 Graham, MS1-2 Hanson, Frances Bailey MS1-2 Harvey, Katherine MS1-2 Holder, Mia MS1-2 Ivos, Neil MS1-2 Jain, Albin MS1-2 John, Daemar MS1-2 Jones, Elizabeth MS1-2 Kamilar, Cimron MS1-2 Kashyap, MS1-2 Kharbat, Abdurrahman MS1-2 Kishan, Raina Janine MS1-2 Klar, Avery MS1-2 Kopacz, Alexander MS1-2 Kroll, Rebecca MS1-2 Kusko, Jessica MS1-2 Lovelace, Sydney MS1-2 Loy, Cameron MS1-2 Ludwig, Parker MS1-2 McCabe, Noriko MS1-2 Merida-Morales, William MS1-2 Miears, MS1-2 Mittal, Nitish MS1-2 Mohammed, Tijani Lexi MS1-2 Neighbors, Rachel MS1-2 Nwaneri, MS1-2 Ochoa, Ozman Dubem MS1-2 Onyejegbu, MS1-2 O’Suoji, Chibuzo Nimra MS1-2 Pasha, Bianca MS1-2 Patel, Dhruv MS1-2 Patel, Shree MS1-2 Patel, Ebrahim MS1-2 Payberah, Laura MS1-2 Perez-Arnold, Cody MS1-2 Perry, Christopher MS1-2 Peterson, Joshua MS1-2 Peterson, Kenna MS1-2 Provost, John MS1-2 Rafael, Jasmin MS1-2 Rahesh, Michael MS1-2 Ramirez, Alexsandra MS1-2 Rojas, Sterling MS1-2 Rosqvist, Stephen MS1-2 Rossettie,

PHAR Bhalerao, Aditya PHAR Bhalerao, Ahmed Ekram PHAR Chowdhury, Itishree PHAR Kaushik, Sharavan PHAR Ramachandran, Snehal PHAR Raut, Siavash PHAR Shahbazi Nia, PHAR Shahi, Sadisna Farzane PHAR Sivandzade, Tuz Fatema PHAR Zahra, MS1-2 Abidi, Hussain Jonathan MS1-2 Abraham, MS1-2 Agusala, Veena MS1-2 Ahmed, Hijab MS1-2 Ali, Kiran MS1-2 Alkul, Mahmud Joey MS1-2 Almaguer, MS1-2 Anand, Rohan Sabiha MS1-2 Armin, Sarah MS1-2 Bayless, MS1-2 Bettiol, Patrick Summre MS1-2 Blakely, Ellen MS1-2 Brown, Michael MS1-2 Carey, MS1-2 Castaneda, Karen Sheila MS1-2 Chandrahas, Danielle MS1-2 Chow, Nathan MS1-2 Chow, MS1-2 Chu, Victoria MS1-2 Coleman, Boone Jaren MS1-2 Covell, Roald MS1-2 Credo, MS1-2 De La Cruz, Noah MS1-2 Doan, Jeremy MS1-2 Drinnon, Kyle MS1-2 Eboh, Stanley Blair MS1-2 Elmore, Avery MS1-2 Endsley, Kristen MS1-2 Fain, Chih Yu MS1-2 Fang, Callie MS1-2 Fort, Caroline MS1-2 Freedle, MS1-2 Fulton, Alec Bernardo MS1-2 Galvan, Ana MS1-2 Garcia, Omar MS1-2 Garcia, MS1-2 Gaschen, Paul

PARTICIPANTS PHAR Akwii, Grace Racheal PHAR Akwii, Grace Sarah PHAR Anderson, GS3+ Bass, Kevin GS3+ Bass, GS3+ Bisht, Karishma GS3+ Blanton, Henry Kayla GS3+ Bounds, Timothy GS3+ Brown, Moamen GS3+ Elmassry, GS3+ Enriquez, Josue Sneider GS3+ Guiterrez, GS3+ Hein, Matthew Sarah GS3+ Hernandez, Ksenija GS3+ Korac, GS3+ Liu, Xiaobo GS3+ Macha, Shawn GS3+ Mazzitelli, Mariacristina Brianyell GS3+ McDaniel-Mims, Caitlyn GS3+ Myers, Diego GS3+ Pedroza, Whitni GS3+ Redman, Bojana GS3+ Ristic, Emma GS3+ Roberts, Bradley GS3+ Schniers, Monica GS3+ Sharma, Faruk Mohd Omar GS3+ Sikder, Ryan GS3+ Sweazey, Emily GS3+ Wright, Victoria GS3+ Young, GS1-2 Jaramillo-Martinez, Valeria GS1-2 Jaramillo-Martinez, Courtney GS1-2 Katz, Morgana GS1-2 Kellogg, Jonathan GS1-2 Kopel, Dalia GS1-2 Martinez-Marin, GS1-2 Mohiuddin, Ismail Stephany GS1-2 Navarro, Rahman Tasmin GS1-2 Omy, Peyton GS1-2 Presto, GS1-2 Seah, Hannah Colton GS1-2 Sniegowski, Rachel GS1-2 Washburn, Joshua GS1-2 Willms, GS1-2 Burrow, Trevor GS1-2 Burrow, Megan GS1-2 Butler, Taylor GS1-2 Hibler, Benjamin GS1-2 Jackson,

JUDGING 16 MS3-4 Kalayilparampil, Bella MS3-4 Hsu,Chia MS3-4 Hope, Landon MS3-4 Hope, Brianna MS3-4 Guerrero Criado, Andres MS3-4 Gates, Megan MS3-4 Frost, Joshua MS3-4 Fisher, John MS3-4 Egan, Alec MS3-4 Domingo-Johnson, E.L. MS3-4 Dixon, Timothy MS3-4 Dhir, Nikita MS3-4 Deleon,Sabrina MS3-4 Dean,Ryan MS3-4 D’Cunha,Ruth MS3-4 Cooper, Chloe MS3-4 Bramnik, Avery MS3-4 Bihari,Sanyukta MS3-4 Beaman,Erica MS3-4 Banerjee, Avantika MS3-4 Arispe, Ryan MS3-4 Anderson, Brittany MS3-4 Alhaj,Sara MS3-4 AlDogom, Sara MS3-4 Ahnood,Elmira MS3-4 Aelety, Udhaya MS1-2 Yim, Vivian MS1-2 Yang, Samuel MS1-2 Yamashiro, Justine MS1-2 Wu, Winnie MS1-2 Wilson,Ellen MS1-2 Wei, Brandon MS1-2 Weaver, Preston MS1-2 Wakil, Anisa MS1-2 Wagstaff, Rachel MS1-2 Vories, Bridget MS1-2 Vo, Diana MS1-2 Upadhyay, Aksha MS1-2 Uke, Nkemjika MS1-2 Tsou, Po-Yang MS1-2 Tidwell, Dalton MS1-2 Telchik, Collin MS1-2 Swinney, Seth MS1-2 Solis, Jessica MS1-2 Snitman,Annie MS1-2 Shepherd, Jessica MS1-2 Sellers, Jake MS1-2 Schrader, Kaylee MS1-2 Sawant, Neha SHP Giles, Jennifer SHP Drusch,Alex SHP Bassett,Cameron R&CF Wu, AmyRuomei R&CF Wallis, Daniel R&CF Stanley, Russell R&CF Shoji,Eri R&CF Sharp, Leigha R&CF Seckel, Shannon R&CF Sarangi, Ashish R&CF Ruiz, Anastasia R&CF Roach, Jenna R&CF Patel, Panna R&CF Nguyen, Jeannie R&CF Milab, Moheb R&CF Metzler, Shane R&CF Loveless-Hoffman, Kelsea R&CF Kumar, Manish R&CF Hamdi,Anas R&CF Daniele, Christopher R&CF Cox, Cameron R&CF Cox, Brittany R&CF Cooper, Claire R&CF Boothe, William MS3-4 Wright, Kandis MS3-4 Wilkerson, Hannah MS3-4 Walterscheid, Brooke MS3-4 Von Spronsen, Nicole MS3-4 Umelo, Jonathan MS3-4 Tran, Timothy MS3-4 Tangela, Nikita MS3-4 Stewart, Caleb MS3-4 Sorensen, Grant MS3-4 Singh,Simran MS3-4 Rouse, Mary MS3-4 Rajasegaran, Abirami MS3-4 Osemwengie, Bradley MS3-4 Nguyen, Emily MS3-4 Mueller, Karl MS3-4 Moreno, Tanir MS3-4 Modi,Trisha MS3-4 Maveddat, Ashley MS3-4 Maniam,Ganesh MS3-4 Lloyd, Nathan MS3-4 Lin,Christine MS3-4 Lee, Shanshan MS3-4 Khandelwal, Jaanki MS3-4 Kelley, John UNDG Zhu,Charles UNDG Young, Kobe UNDG Wolpert, John UNDG Schneider, Rebecca UNDG Reynolds, Landrye UNDG Ostermaier, Emily UNDG Lopez,Andrea UNDG Kjellgren, Abbey UNDG Kariampuzha, William UNDG Ibrahim, Andrew UNDG Delgado, Betsaida UNDG Ball,Reagan SHP Vintimilla, Antonio SHP Steven, Khalid SHP Sanders, Emma SHP Pingsterhaus, Ashly SHP Natesan,Karthick SHP Murphy, Brandi SHP Liu,Yilan 17 JUDGING

, March 10, 2020 , March 10, 2020 , March Name Landrye Reynolds, Rebecca Schneider, John Wolpert, Kobe Young, Zhu, Charles Abbey Kjellgren, Emily Ostermaier, Ball, Reagan Andrew Ibrahim, Name Ksenija Korac, Sharma, Monica Whitni Redman, Macha, Shawn Bounds, Kayla Liu, Xiaobo Name Bass, Kevin Moamen Elmassry, Caitlyn Myers, Emily Wright, Timothy Brown, Wednesday, March 11, 2020 March Wednesday, (All the following times are PM!) times are (All the following PM!) times are (All the following (All the following times are AM!) times are (All the following Time 8:30-8:45 8:45-9:00 9:00-9:15 9:15-9:30 9:30-9:45 10:15-10:30 10:45-11:00 11:15-11:30 11:45-12:00 Time 1:30-1:45 1:45-2:00 2:00-2:15 2:15-2:30 2:45-3:00 3:00-3:15 Time 1:45-2:00 2:00-2:15 2:15-2:30 2:30-2:45 3:00-3:15 Judging Group 4A - Tuesday Judging Group 5A - Tuesday Judging Group Judging Group 1A - Judging Group Poster W1 W2 W3 W4 W5 BREAK W6 W7 10:00-10:15 W8 W90 William Kariampuzha, 10:30-10:45 W10 W11 11:00-11:15 Andrea Lopez, W12 W13 Andrea Perez, 11:30-11:45 Betsaida Delgado, Poster TU24 TU25 TU26 TU27 BREAK TU28 TU29 TU30 TU31 3:15-3:30 3:30-3:45 Josue Enriquez, Victoria Young, Poster TU32 TU33 1:30-1:45 TU34 TU35 Bojana Ristic, TU36 BREAK TU37 TU38 TU39 3:15-3:30 3:30-3:45 Ryan Sweazey, Sarah Hernandez,

, March 10, 2020 , March , March 10, 2020 , March , March 10, 2020 , March Name Bradley Schniers, Emma Roberts, Henry Blanton, Karishma Bisht, Name Benjamin Jackson, Stephany Navarro, Peyton Presto, Colton Sniegowski, Trevor Burrow, Tasmin Rahman Omy, Name Taylor Hibler, Rachel Washburn, Willms, Joshua Kellogg, Morgana Jonathan Kopel, Mohiuddin, Ismail

(All the following times are PM!) times are (All the following (All the following times are PM!) times are (All the following (All the following times are PM!) times are (All the following

Time 1:45-2:00 2:00-2:15 3:00-3:15 3:15-3:30 Time 1:30-1:45 1:45-2:00 2:00-2:15 2:15-2:30 2:30-2:45 3:00-3:15 Time 1:30-1:45 1:45-2:00 2:15-2:30 2:45-3:00 3:00-3:15 3:30-3:45 Judging Group 3A - Tuesday Judging Group Judging Group 2A - Tuesday Judging Group

Judging Group 1A - Tuesday Judging Group JUDGING GROUPS JUDGING

TU16 TU17 1:30-1:45 TU18 TU19 Brianyell McDaniel Mim, TU20 2:15-2:30 BREAK 2:30-2:45 TU21 Sneider Gutierrez, TU22 Hein, Matthew TU23 3:30-3:45 Mariacristina Mazzitelli, Poster TU9 TU10 TU11 TU12 TU13 BREAK TU14 TU15 3:15-3:30 Courtney Katz, Poster TU1 TU2 TU3 TU4 2:00-2:15 BREAK TU5 TU6 Valeria Jaramillo-Martin, TU7 TU8 3:15-3:30 Dalia Martinez-Marin, Poster

JUDGING 18 Jones,Daemar W77 Ochoa,Ozman W76 10:45-11:00 W75 10:30-10:45 W74 Vories, Bridget W73 W72 9:45-10:00 BREAK W71 W70 W69 W68 W67 W66 Poster Wallis, Daniel 10:45-11:00 W55 W54 W53 W52 Loveless-Hoffman, Kelsea W51 BREAK W50 9:00-9:15 W49 W48 W47 W46 Poster W35 W34 Metzler, Shane W33 Ruiz,Anastasia W32 10:00-10:15 Daniele,Christopher W31 9:45-10:00 Cox, Brittany W30 W29 9:15-9:30 BREAK 9:00-9:15 W28 W27 W26 W25 Poster Judging Group 4A- Judging Group 3A - Judging Group 2A - 11:30-11:45 11:15-11:30 11:00-11:15 10:15-10:30 9:30-9:45 9:15-9:30 9:00-9:15 8:45-9:00 8:30-8:45 Time 11:00-11:15 10:30-10:45 10:15-10:30 10:00-10:15 9:30-9:45 9:15-9:30 8:45-9:00 8:30-8:45 Time 11:15-11:30 11:00-11:15 10:45-11:00 10:30-10:45 10:15-10:30 8:45-9:00 8:30-8:45 Time (All thefollowing timesare AM!) (All thefollowing timesare AM!) (All thefollowing timesare AM!) Wednesday, March 11,2020 Wednesday, March 11,2020 Wednesday, March 11,2020 Credo, Roald Coleman, Boone McCabe, Parker Mohammed, Tijani Sellers, Jake Provost, Kenna Almaguer, Joey Fulton, Alec Gore, Megh Name Hamdi, Anas Stanley, Russell Sharp, Leigha Sarangi, Ashish Ruomei Wy, Amy Milad, Moheb Kumar, Manish Cox, Cameron Name Roach, Jenna Shoji, Eri Seckel, Shannon Patel, Panna Nguyen, Jeannie Cooper, Claire Boothe, William Name

4 30-:5 Rossettie, Stephen W45 W44 Ramirez, Michael W43 3:00-3:15 W42 Tidwell, Dalton W41 2:30-2:45 BREAK W40 2:00-2:15 W39 W38 W37 W36 Poster W24 W23 Yamashiro, Justine W22 W21 W20 2:45-3:00 Vo, Diana W19 W18 BREAK 2:00-2:15 W17 W16 W15 W14 Poster 6 33-:5 Perez-Arnold, Laura Patel, Dhruv W65 3:30-3:45 W64 3:15-3:30 W63 Onyejegbu, Dubem W62 BREAK W61 2:15-2:30 W60 W59 W58 W57 W56 Poster Judging Group 2B - Judging Group 1B - Judging Group 3B- 4:00-4:15 3:45-4:00 3:30-3:45 3:15-3:30 2:15-2:30 1:45-2:00 1:30-1:45 Time 4:15-4:30 4:00-4:15 3:45-4:00 3:30-3:45 3:15-3:30 3:00-3:15 2:15-2:30 1:45-2:00 1:30-1:45 Time 4:00-4:15 3:45-4:00 2:45-3:00 2:30-2:45 2:00-2:15 1:45-2:00 1:30-1:45 Time (All thefollowing timesare PM!) (All thefollowing timesare PM!) (All thefollowing timesare PM!) Wednesday, March 11,2020 Wednesday Wednesday Snitman, Annie Shepherd, Jessica Schrader, Kaylee Sawant, Neha Tsou, Po-Yang Perry, Cody Peterson, Joshua Name Wu, Winnie Wei. Brandon Weaver, Preston Uke, Nkemjika Endsley, Avery Nwaneri, Rachel Wakil, Anisa Rafael, John Solis, Jessica Name Peterson, Christopher Abraham, Jonathan Patel, Bianca Pasha, Nimra Telchik, Collin Merida-Morales, Noriko Miears, William Name , March 11,2020 , March 11,2020

19 JUDGING

Name Harris, Michelle Omar Garcia, Ahmed, Hijab Blair Elmore, Sheila Chandrahas, Mia Ivos, Aljah, Sara John Kelley, Udhaya Aelety, Abirami Rajasegaran, Name Anna Nevels, Cimron Kashyap, Lexi Neighbors, Janine Klar, Ebrahim Payberah, Alexsandra Rojas, Sterling Rosqvist, Name Gaschen, Paul Anand, Rohan Summre Blakely, Ellen Brown, Karen Castaneda, Nathan Chow, Kishan, Raina Jared Covell, Samuel Yang, (All the following timings are AM!) timings are (All the following (All the following timings are AM!) are timings following (All the AM!) timings are (All the following Time 8:30-8:45 8:45-9:00 9:00-9:15 9:15-9:30 9:45-10:00 10:30-10:45 11:00-11:15 11:15-11:30 11:30-11:45 11:45-12:00 Time 8:30-8:45 8:45-9:00 9:15-9:30 9:30-9:45 10:00-10:15 11:00-11:15 11:15-11:30 Time 8:30-8:45 8:45-9:00 9:00-9:15 9:15-9:30 9:30-9:45 10:00-10:15 10:15-10:30 10:30-10:45 10:45-11:00 Judging Group 4A - Thursday, March 12, 2020 March 4A - Thursday, Judging Group Judging Group 2A - Thursday, March 12, 2020 March Thursday, 2A - Group Judging 12, 2020 March 3A - Thursday, Judging Group Poster TH73 TH74 TH75 TH76 TH77 TH78 9:30-9:45 TH79 BREAK 10:00-10:15 Elizabeth Kamilar, TH80 Rachel TH81 Wagstaff, TH82 10:45-11:00 TH83 TH84 Nitish Mittal, TH85 Poster TH25 TH26 TH27 TH28 9:00-9:15 TH29 TH30 Vivian Yim, TH31 9:45-10:00 BREAK TH32 Avery Kopacz, TH33 10:30-10:45 TH34 10:45-11:00 TH35 O’Suoji, Chibuzo Drinnon, Kyle TH36 11:30-11:45 Chu, Victoria Poster TH49 TH50 TH51 TH52 TH53 BREAK TH54 TH55 TH56 TH57 TH58 TH59 11:00-11:15 TH60 11:15-11:30 De La Cruz, Noah 11:30-11:45 Derrick Graham, Danielle Chow,

, March 11, 2020 , March , March 11, 2020 , March Name Mahmud Alkul, Armin, Sabiha Wilson, Ellen Rahesh, Jasmine Aksha Upadhyay, Hanson, Frances Eboh, Stanley Kristen Fain, Callie Fort, Caroline Freedle, Sarah Bayless, Name Michael Carey, Bernardo Galvan, Asher George, Abidi, Hussain Ali, Kiran Shree Patel, Seth Swinney, Adburrahman Kharbat, Bailey Harvey, Name Jain, Neil Katherine Holder, John, Albin Alexander Kroll, Rebecca Kusko, Jessica Lovelace, Sydney Loy, Ludwig, Cameron Ana Garcia, Chih Yu Fang, Wednesday Wednesday (All the following times are PM!) are times (All the following (All the following times are PM!) are times following (All the (All the following timings are AM!) timings are (All the following Time 8:30-8:45 8:45-9:00 9:15-9:30 9:30-9:45 10:00-10:15 10:15-10:30 10:30-11:45 10:45-11:00 11:00-11:15 11:15-11:30 11:30-11:45 Time 1:30-1:45 1:45-2:00 2:00-2:15 2:15-2:30 3:00-3:15 3:15-3:30 3:30-3:45 3:45-4:00 4:00-4:15 Time 1:30-1:45 2:00-2:15 2:15-2:30 2:45-3:00 3:00-3:15 3:15-3:30 3:30-4:45 3:45-4:00 4:00-4:15 4:15-4:30 Judging Group 1A - Thursday, March 12, 2020 March 1A - Thursday, Judging Group Judging Group 5B - Judging Group Judging Group 4B - 4B - Group Judging TH1 TH2 TH3 TH4 9:00-9:15 TH5 BREAK TH6 Patrick Bettiol, TH7 TH8 TH9 TH10 TH11 TH12 Poster Poster W89 W90 W91 W92 W93 BREAK 2:30-2:45 W94 W95 W96 Agusaia, Veena W97 W98 Poster W78 W79 W80 1:45-2:00 W81 BREAK W82 Doan, Jeremy W83 W84 W85 W86 W87 W88

JUDGING 20 H6 :041 Sivandzade, Farzane TH48 ShahbaziNia,Siavash 4:00-4:15 TH47 TH46 3:30-3:45 TH45 Zahra, Fatema Tuz TH44 TH43 2:45-3:00 BREAK Kaushik, Itishree TH42 TH41 2:00-2:15 TH40 TH39 TH38 TH37 Poster Pedroza, Diego 4:30-4:45 Vintimilla, Antonio TH24 TH23 3:45-4:00 TH22 TH21 TH20 TH19 TH18 BREAK Drusch,Alex TH17 Bassett, Cameron TH16 1:45-2:00 TH15 1:30-1:45 TH14 TH13 Poster AlDogom, Sara TH109 11:30-11:45 Deleon,Sabrina TH108 Dean,Ryan TH107 11:00-11:15 D’Cunha, Ruth TH106 10:45-11:00 TH105 10:30-11:45 Dhir, Nikita TH104 TH103 10:00-10:15 TH102 BREAK TH101 TH100 TH99 TH98 TH97 Poster Judging Group 5A -Thursday, March 12,2020 Judging Group 2B-Thursday, March 12,2020 Judging Group 1B -Thursday, March 12,2020 4:30-4:45 4:15-4:30 3:45-4:00 3:15-3:30 2:30-2:45 2:15-2:30 1:45-2:00 1:30-1:45 Time 4:15-4:30 4:00-4:15 3:30-3:45 3:15-3:30 3:00-3:15 2:30-2:45 2:15-2:30 2:00-2:15 Time 11:45-12:00 11:15-11:30 10:15-11:30 9:30-9:45 9:15-9:30 9:00-9:15 8:45-9:00 8:30-8:45 Time (All thefollowing timingsare AM!) (All thefollowing timingsare PM!) (All thefollowing timingsare PM!) Butler, Megan Anderson, Sarah Shahi, Sadisna Chowdhury, Ekram Ahmed Bhalerao, Aditya Ramachandran, Sharavan Raut, Snehal Akwii, RachealGrace Name Sikder, MohdOmar Natesan, Karthick Steven, Khalid Sanders, Emma Pingsterhaus, Ashly Murphy, Brandi Liu, Yilan Giles, Jennifer Name Lee, Shanshan Bihari, Sanyukta Tangella, Nikita Lloyd, Nathan Gates, Megan Rouse, Mary Hope, Landon Mueller, Karl Name

H6 :543 Anderson, Brittany 4:15-4:30 TH96 TH95 TH94 TH93 TH92 TH91 BREAK Lin,Christine TH90 TH89 1:45-2:00 TH88 TH87 TH86 Poster Van Spronsen, Nicole TH72 4:00-4:15 TH71 TH70 TH69 TH68 TH67 Dixon, Timothy TH66 BREAK 2:15-2:30 TH65 TH64 TH63 TH62 TH61 Poster TH120 Domingo-Johnson, E.L. TH119 TH118 TH117 3:15-3:30 TH116 TH115 TH114 Banerjee,Avantika BREAK TH113 TH112 1:45-2:00 TH111 TH110 Poster Judging Group 4B -Thursday, March 12,2020 Judging Group 3B -Thursday, March 12,2020 Judging Group 5B-Thursday, March 12,2020 4:00-4:15 3:45-4:00 3:30-3:45 3:15-3:30 3:00-3:15 2:30-2:45 2:15-2:30 2:00-2:15 1:30-1:45 Time 4:30-4:45 4:15-4:30 3:45-4:00 3:30-3:45 3:15-3:30 3:00-3:15 2:30-2:45 2:00-2:15 1:45-2:00 1:30-1:45 Time 4:15-4:30 4:00-4:15 3:45-4:00 3:30-3:45 3:00-3:15 2:45-3:00 2:15-2:30 2:00-2:15 1:30-1:45 Time (All thefollowing timingsare PM!) (All thefollowing timingsare PM!) (All thefollowing timingsare PM!) Osemwengie, Bradley Kalyilparampil, Bella Bramnik, Avery Guerrero Criado, Andres Egan, Alec Khandelwal, Jaanki Sorensen, Grant Beaman, Erica Cooper, Chloe Name Seah, Hannah Arispe, Ryan Wright, Kandis Frost, Joshua Umelo, Jonathan Fisher, John Modi, Trisha Tran, Timothy Moreno, Tanir Singh, Simran Name Maniam, Ganesh Wilkerson, Hannah Nguyen, Emily Ahnood, Elmira Hsu, Chia Stewart, Caleb Walterscheid, Brooke Hope, Brianna Maveddat, Ashley Name

21 JUDGING - - - GRADUATE STUDENTS YEARS 1-2 YEARS STUDENTS GRADUATE School: Graduate School of Biomedical Sciences peutic options are urgently required. We identified pizotifen, a blood-brain barrier permeable drug currently used for the treatment of treatment the for used currently drug permeable barrier blood-brain a pizotifen, identified We required. urgently are options peutic migraines, and investigated its anti-cancer effects on SF188, a human pediatric GBM cell line, and further evaluated the molecular of SF188 mechanisms. Our results demonstrate that treatment cells with pizotifen for 24-72 hours significantly suppressed the sur that indicate also results Our µM. 32-60 from ranging IC50 with manner, time-dependent and concentration a in cells SF188 of vival by confirmed further was Apoptosis assay. V/APC Annexin by analyzed as manner dose-dependent a in apoptosis induced pizotifen phosphory- reduced in resulted treatment pizotifen that show also results Our blotting. western by PARP and caspase-3 of cleavage expres- Bcl-2 protein anti-apoptotic whereas increased was Bax protein pro-apoptotic of expression The 705. Tyr at STAT3 of lation together, sion was decreased in Taken response of pizotifen treatment. Bcl-2 is known to be transcriptionally regulated by STAT3. Further signaling. STAT3 of inhibition the with associated possibly was cells GBM of inhibition growth the that indicate results our mechanistic studies are in progress. Glioblastoma multiforme (GBM) is considered as one of the most common and aggressive brain tumors. The 5-year survival rate and radiation by followed resection, surgical of consists treatment of standard current The problem. health major a it making 5%, is chemotherapy with temozolomide (TMZ). over However, 50% of patients do not respond therefore, to TMZ novel therapy, thera Megan Butler, Sahdeo Prasad, Sanjay K Srivastava Megan Butler, GS1-2 BUTLER, MEGAN GS1-2 BUTLER, by inducing apoptosis glioblastoma cell growth Pizotifen, an anti-migraine drug, suppresses School: Graduate School of Biomedical Sciences School: Graduate School of Biomedical Detection of C-circles in plasma provides an alternative to obtaining tumor tissue in order to identify ALT+ neuroblastoma patients. neuroblastoma ALT+ identify to order in tissue tumor obtaining to alternative an provides plasma in C-circles of Detection Use of as EDTA an anticoagulant is optimal, but heparin depletion enables use of the CCA in diminished sensitivity. heparinized plasma, though with The alternative lengthening of telomeres mechanism (ALT) is present in approximately 20% of specific and high-risk sensitive a neuroblastoma are tumors, repeats, DNA telomeric circular self-primed C-circles, prognosis. lethal often but indolent, an conferring many in biomarker useful potentially a be to shown been has (cfDNA) DNA cell-free Plasma-derived cancers. ALT+ for biomarker heparin and EDTA both in collected cfDNA in detected be could C-circles that hypothesized We neuroblastoma. including cancers, EDTA in collected was Plasma ng/ml). 1 and 10, 100, (1000, dilutions serial using plasma fresh of ml 2 into seeded was DNA ALT+ were C-circles Kit. Acid Nucleic Circulating QIAamp the using extracted was cfDNA and tubes, Vacutainer BD heparin lithium and readily detected down to 10 ng/ml in plasma as using an EDTA anticoagulant. The failed CCA in heparinized samples, as likely, ecteola with pre-treated were that samples heparinized in detected be could however, C-circles, inhibitor. polymerase is a heparin Bacteroides of Use sensitivity. diminished to due volume reaction larger a required this but heparin, remove to (50-55mg) cellulose metastatic with plasma marrow bone in positive was CCA The CCA. of inhibition heparin overcome not did units) (24 I Heparinase neuroblastoma that grew a CCA+ neuroblastoma cell line and in peripheral blood plasma from a neuroblastoma. patient with an ATRX-mutant Trevor Burrow, Erin K. Barr, Shawn Macha, C. Patrick Reynolds Erin K. Barr, Burrow, Trevor patients. neuroblastoma ALT+ ized tubes to identify Detection of Alternative Lengthening of Telomeres Phenotype via C-Circle Assay in EDTA and Heparinized Plasma Heparinized Plasma and EDTA Assay in Phenotype via C-Circle of Telomeres Alternative Lengthening of Detection GS1-2 BURROW, TREVOR GS1-2 BURROW,

ABSTRACTS 22 School: GraduateSchoolofBiomedical Sciences new pharmacotherapeutictreatmentforRA. promising a be may CMM that suggest data These inflammation. joint with associated symptoms systemic and local the of many analysis as well as complete blood cell count and serum concentrations of inflammatory cytokines. We found that CMM attenuated histopathological using measured was severity RA of determinations Endpoint sensitivity. nociceptive measured assays filament ments and volume displacement for paw swelling, infrared heat signatures for inflammation, and both hotplate (42 ⁰C) and von Frey groups were injected with saline or 75mg/kg MMC (i.p.) every other day through day 21. RA was quantified using caliper measure- RAtreatment of symptoms, development the Following saline. with treated were animals Control lipopolysaccharide. colit E. ug? 50 of (i.p.) injection an by later days 3 followed II type collagen in epitopes different against directed antibodies monoclonal 5 of activity in a murine model of RA. Joint inflammation was induced in male and female DBA/1J mice via injection (i.p.) of a cocktail microbiota. Here, we report the anti-inflammatory activity of a chemically modified minocycline (CMM) analog with no antibiotic gastrointestinal the on side-effects negative the is antibiotics of use long-term the for obstacle However,RAan success. treatment in role a key play to posited ficacy. are minocycline of Anti-inflammatory, properties immunomodulatory, chondro-protective and ef- shown have models murine in (RA) arthritis rheumatoid of treatment the for derivatives tetracycline of use off-label of Reports Grisham, andSusanE.Bergeson B. Matthew TedW.Reid, Enriquez, Josue McDaniel, Brianyell Furr, Katheryn Kisby, Brent Willms, Joshua Jackson, Benjamin Chemically modifiedminocyclineasanoveltherapeuticfor rheumatoid arthritis GS1-2 JACKSON, BENJAMIN School: GraduateSchoolofBiomedicalSciences are criticalforsurvivalofpSCgraftsandsuggeststheynecessarytoinduceimmunetolerance. IL-10 and pathway signaling study.the TGFβ/SMAD the both however,throughout that mice, survived demonstrates control This in Grafts 20. day by rejection graft experienced mice knockdown IL-10 and SMAD2/3 of 100% survival. pSC determine to tibody WT-1a using tissue an- graft specific on performed was analysis Immunohistochemical mice. B6 knockdown IL-10 or SMAD2/3 into transplanted were mice BALB/c old 20-day from isolated generate pSC to survival. Tregs,graft known both SC in IL-10, and Toinduce pSC which by mechanism the understand further Tregs,the of role the investigated we pathway signaling TGFβ/SMAD without the use of immune suppressive drugs. Previously, our lab has found that Tregs play an important role in pSC graft survival. 100 days. Understanding the mechanism by which pSC protect co-transplant islets will help us improve islet graft survival to 100% of upwards survived grafts of 60% islets, with drugs. co-transplanted immunosuppressive When harsh on relying of instead testes, improving islet transplant survival by co-grafting them with primary Sertoli cells (pSC), an immune protective cell type found in the on focuses lab nearly Our needed. are transplantation islet in are advances Therefore, post-transplantation. years five by grafts rejected completely the drugs, these with even and, drugs immunosuppressive harmful requires procedure this However,year. a of upwards for independent insulin remain to recipients of 80% allowing glucose, blood elevated to response in insulin produce fully success- can islets of transplantation Clinical transplantation. islet is treatment alternative expensive. Apromising increasingly is Current treatment for Type I Diabetes, insulin replacement, has limited success as it is difficult to achieve glucose homeostasis and Taylor Hibler, Dr. Gurvinder Kaur, Dr. Kandis Wright, andDr. JannetteDufour SMAD2/3, IL-10,andyou: A Sertolicell’s guidetopromoting allograftsurvival GS1-2 HIBLER,TAYLOR 23 ABSTRACTS - - - - School: Graduate School of Biomedical Sciences tuted in nanodisc and studied at 37°C) different conformational changes are thought to be seen within the NBDs in the presence of substrates and inhibitors suggesting varying binding pockets cysteine-less within Pgp A the with TMDs. two cysteines introduced chelate-maleimide Tb3+ probes, LRET with labeling for used was Pgp-NT) mutant, (N607C/T1252C NBDs the in positions two at was previously reported (donor) to and decrease Bodipy the FL-maleimide distance Verapamil (acceptor). between NBDs indicat a show taxol, and valinomycin verapamil, Substrates, NBDs. separated more and dimers NBDs closed conformations, main two ing showing molecules of percentage higher a with coinciding Å 13-15 around at (d2-d1) distances donor-acceptor in difference smaller d2-d1 larger in resulting true be to opposite showed zosuquidar, and tariquidar Inhibitors, 45%. about of (M1) dimer NBD closed a distances and a decreased percentage of closed NBD dimers during hydrolysis. This information can be used to better understand the movement and mechanism of Pgp during substrate and inhibitor binding. P-glycoprotein (Pgp) is a multidrug transporter consisting of two transmembrane domains (TMDs) and two nucleotide binding do- binding nucleotide two and (TMDs) domains transmembrane two of consisting transporter multidrug a is (Pgp) P-glycoprotein from Energy agents. chemotherapeutic many including compounds, of variety a wide of efflux an in involved are that (NBDs) mains Understand- protein. entire the throughout seen changes conformational in resulting hydrolysis constitute NBDs the to binding ATP exporting and binding for mechanism structural the to insight provide will hydrolysis ATP during changes conformational these ing these drugs and toxins. Using luminescence resonance energy transfer (LRET) under conditions near-physiological (Pgp reconsti Department of Cell Physiology and Molecular Biophysics, Department of Cell Biology and Biochemistry, and Center USA for Texas, Lubbock, Mem- University Health Sciences Center, Tech Texas brane Protein Research, Courtney L. Katz, Mariana C. Fiori, Benjamin T. Jackson, Ina L. Urbatsch and Guillermo A. Altenberg A. Jackson, Ina L. Urbatsch and Guillermo T. Courtney L. Katz, Mariana C. Fiori, Benjamin GS1-2 KATZ, COURTNEY GS1-2 KATZ, Substrate to Response in P-glycoprotein Transporter Multidrug the of Cycle Hydrolysis ATP the Changes during Conformational Binding School: Graduate School of Biomedical Sciences School: Graduate School of Biomedical lopathy. This lopathy. is an autosomal recessive disease which affects females and males Children equally. with this rare disease develop seizures shortly after birth, which continues and throughout slowtheir and life. limited Symptoms motor include speech difficulty, Pichia Yeast studies. biophysical and biochemical for SLC13A5 human purify and express to is research this of purpose The skills. differ Moreover, cost. affordable at growth density cell high produces that system expression protein well-established a is Pastoris ent eukaryotic membrane proteins showed successful expression in this facilitate system. To cellular localization and purification N-terminal and C-terminal tags were engineered and tested to support transport function. An N-terminal His_10-SUMO domain was tested for its ability to was enhance engineered C-terminal solubility to –Twin-Strep-tag GFP and facilitate A protein folding. cellular localization studies and protein purification. Fluorescence microscopy showed His_10-SUMO- SLC13A5-GFP-StrepNa^+-coupled lo- demonstrate we [^14C]-citrate, Using cells. pastoris P. in membrane plasma and reticulum endoplasmic the to calized source material for future protein purification. pastoris may provide excellent Thus, P. citrate transport in cells. The human Na^+-coupled citrate transporter (Solute carrier SLC13A5) assists in the uptake of Na^+ and citrate^3- ions into in expressed mostly is SLC13A5 brain, the the In testis. and liver brain, in expressed transporter membrane plasma a is SLC13A5 cell. acetylcholine, neurotransmitters the of synthesis for precursor a as also and source energy an as serve might citrate where neurons, GABA, and glutamate. Furthermore, loss-of-function mutations in SLC13A5 are associated with early infantile epileptic encepha Valeria Jaramillo-Martinez, Vadivel Ganapathy, Ina L. Urbatsch Ganapathy, Vadivel Jaramillo-Martinez, Valeria GS1-2 JARAMILLO-MARTINEZ, VALERIA JARAMILLO-MARTINEZ, GS1-2 pastoris in the yeast Pichia (SLC13A5) coupled citrate transporter human Na+- of functional Expression

ABSTRACTS 24 School: GraduateSchoolofBiomedical Sciences studies uncoveranovelmechanismfortheanti-diabeticactions ofmetformin. These gluconeogenesis. inhibit and glycolysis stimulate would citrate of levels cellular in fructose-1,6- decrease the stimulating therefore, by bisphophatase; gluconeogenesis activate and phosphofructokinase-1 inhibiting by glycolysis suppress to known is cAMP signaling is CREB; decreased levels of phospho-CREB seem to mediate the observed effects of metformin on NaCT. Citrate and to mTOR, relevant of is downstream that factor AMPK transcription inhibits NaCTexpression. The decreases also rapamycin mTORinhibitor the AMPK levels. mRNA decreased with associated is expression NaCT in decrease The affinity. substrate in cleotide (AICAR), an AMPK activator, elicits a similar effect. The process involves a decrease in maximal velocity with no change ribonu- 5-Aminoimidazole-4-carboxamide citrate. of levels cellular decreases and cells HepG2 in NaCT transporter citrate brane mem plasma the of expression the inhibits Metformin mechanism. unknown hitherto a on report we Here (AMPK). AMPkinase of activation metformin-mediated on depend actions These gluconeogenesis. from away precursors NADH/ glucose diverts cytoplasmic ratio in NAD+ increase resultant the and shuttle, I-glycerophosphate and I complex inhibits Metformin effect. diabetic Metformin is the first-line treatment for type 2 diabetes. Inhibition of hepatic gluconeogenesis is the primary contributor to its anti- Jonathan Kopel,KeiHiguchi,BojanaRistic, Toshihiro Sato,SabarishRamachandran,and Vadivel Ganapathy The HepaticPlasmaMembraneCitrateTransporter NaCT (SLC13A5)asa MolecularTarget forMetformin GS1-2 KOPEL, JONATHAN School: GraduateSchoolofBiomedicalSciences on theexpressionofindividualsubunits. a primaryroleinmRNAsubunit has the RAPPprotection, regulationof pathway, and thattheSRP stability depend biogenesis and the lysosomal, rather than proteasomal, degradation pathway in this process. In conclusion, our results demonstrate that the SRP54 of involvement the suggests also data Our proteins. of stability the with connected is effect the that suggesting others of depletion the by affected not were subunits SRP individual each of mRNAInterestingly,levels the knockdown. SRP72 and SRP68 affected by only was expression protein SRP19 and silencing, 72 and 68, SRP19, by affected was expression protein SRP54 biogenesis. subunits. Thus, heterodimer-forming subunits of SRP9/14 and SRP68/72 affect each other’s protein level, suggesting their coherent tion, and SRP9/14 appear nonessential in RAPP. We also discovered that depletion of some SRP subunits affect expression of other demonstrates that SRP54 is unique in its crucial role of mRNA protection, while SRP19, 68, and 72 have moderate supportive func- data Our cells. human cultured RAPP in on effect and stability their analyzed and subunits individual of knockdowns by complex individual that hypothesize WeRNA. SRPfor functions distinct have subunits RAPPthe and stability noncoding complex response. Toone SRPthe “dissected” we hypothesis, this test and subunits protein six of consists SRP cells. the in products aberrant of accumulation prevent to proteins secretory of degradation mRNA specific to leads This initiated. is pathway (RAPP) Production of Protein Regulation Aberrant the sequences, signal recognize to able not SRPis When diseases. human multiple with connected reticulum. This process is essential and its disruption, caused by mutations in the signal sequences or by defects in the SRP itself, is The signal recognition particle (SRP) recognizes and targets secretory proteins with an N-terminal signal peptide to the endoplasmic Morgana K.Kellogg,ElenaB. Tikhonova, KevinBass,PaulD’Cunha, Andrey L.Karamyshev Decoding theMolecularMechanismofSRP Subunits’ InvolvementinRAPP GS1-2 KELLOGG, MORGANA - 25 ABSTRACTS - - - School: Graduate School of Biomedical Sciences esis, these therapies are often non-specific and are susceptible to chemoresistance. In this study, we introduce a strategy to enhance to strategy a introduce we study, this In chemoresistance. to susceptible are and non-specific often are therapies these esis, the selectivity and to overcome resistance of these compounds by identifying inhibitors that target kinase-substrate interactions. c-MYC overexpression and deregulation has been implicated in many have cancers. previously We identified that OCT4 binds to activity OCT4 of mediator a as identified was DNA-PKcs c-MYC. activate transcriptionally to region promoter/enhancer MYC the identified the domains We ofin DNA-PKcsthis necessarypathway. to bind and phosphorylate OCT4. The current project aims to efficacy. and selectivity their validate to and interaction DNA-PKcs-OCT4 the prevent that compounds identify to assay an develop OCT4 of fragments the co-expressed we activation, transcriptional c-MYC to related interaction protein-kinase the target to order In required for c-MYC expression and the fragments DNA-PKcs required to activate OCT4 to DNA-PKcs 1) and confirmOCT4; 2) thedevelop a interactioncell-based between assay to screen novel compounds that prevent this interaction. co-transduced We then screened a chemical the crucial We fragments of DNA-PKcs and OCT4 tagged cells. with luminescent probes in HEK 293FT library of compounds to identify “hits” that inhibited luminescence (thus our kinase-substrate protein interaction). 67 compounds inhibited the validated luminescence these interaction 67 between hits the by tagged OCT4 and DNA-PKcs We protein fragments. co- by OCT4 and DNA-PKcs between binding of inhibition the 2) expression; c-MYC and pOCT4S93 in decrease a 1) confirming: of phosphorylation DNA-PKcs-mediated impair 1) that compounds novel 7 identified have we conclusion, In immunoprecipitation. OCT4; 2) inhibit the DNA-PKcs-OCT4 kinase-substrate interaction. The majority of binding the sites FDA-approved of kinase kinases. ATP inhibitors Despite target their activity against tumorigen Ismail Syed Mohiuddin, Sung-Jen Wei, Min H. Kang Wei, Ismail Syed Mohiuddin, Sung-Jen GS1-2 MOHIUDDIN, ISMAIL GS1-2 MOHIUDDIN, Kinase inhibitors to identify novel DNA-dependent Protein assay cell-based screening A School: Graduate School of Biomedical Sciences School: Graduate School of Biomedical tive induction intensive chemotherapy, myeloablative and chemotherapy, then maintenance therapy with 13-cis-retinoic acid and + dinu- chemotherapy with recurrent NB are often treated + cytokines. Children who develop dinutuximab the anti-GD2 antibody tuximab. Our laboratory has shown that patients with relapse NB often have diminished expression of GD2, the disaloganglioside chemotherapy with combined dinutuximab patients, in observed is what to similar that shown also have We dinutuximab. binds that enhances responses and survival of mice with NB PDXs that have expression GD2 low As high binding. dinutuximab dinutuximab low with PDXs NB carrying mice in binding. chemoimmunotherapy of activity to contribute However, dinutuximab does not appears to promote resistance to chemoimmunotherapy of NB we sought to determine low the GD2 molecular expression. mechanism(s) underlying We conducted RNA-sequencing on NB patient-derived cell lines and established prior to patient-derived therapy and at xenografts relapse and analyzed (PDXs) the data using the EdgeR package in R language to identify differentially (encodes gene ST8Sia1 the of expression that show data RNAseq samples. relapse and diagnosis between (DEGs) genes expressed for GD3 synthase, an immediate precursor to GD2) and the B4GALNT4 gene, a family member of B4GALNT1 (encodes for the final enzyme step in GD2 synthesis) are both downregulated (p<0.005, p<0.0005) in progressive disease NB samples compared to those obtained at diagnosis. Dinutuximab binding was assessed by flow cytometry in NB PDXs, and demonstrated a strong cor relation to GD3 synthase expression. Examination of transcription factors known GD3 both to of expression diminished bind toward point data These to expression. the mRNA ST8Sia1 GD3 with correlate also promoter revealed mRNA NFkB1 and ETS1 that synthase and B4GALNT4 as potential mechanisms of diminished dinutuximab binding to NB. Future studies forced down-regulation will of these genes confers resistance to chemoimmunotherapy of NB and if overexpression of these genes can determine if reverse such resistance. Neuroblastoma Neuroblastoma (NB) is the most frequent extracranial solid tumor in children, accounting cytoreduc for with treated are markers) molecular and spread, about of degree age, by (identified disease 10% high-risk with patients NB deaths. of all pediatric cancer Dalia Martinez-Marin, Michelle Heid (Ph.D), Patrick Reynolds (M.D,Ph.D) Heid (Ph.D), Patrick Michelle Dalia Martinez-Marin, GS1-2 MARTINEZ-MARIN, DALIA MARTINEZ-MARIN, GS1-2 binding in Neuroblastoma diminished dinutuximab mechanisms of B4GALNT4 as potential GD3 synthase and Assessing

ABSTRACTS 26 School: GraduateSchoolofBiomedical Sciences synthesis andevaluationofnovel RAD6inhibitorstoincreasetheefficacyandthosethat workinsyner include studies Future patients. OC of survival free disease improve and OC chemoresistant of treatment the targetfor therapeutic important an be could RAD6 that show Collectively,findings carboplatin. these to lines cell OC chemoresistant of resensitization or small molecule inhibitor TZ9 attenuated the expression of DNA damage response and stem cell signaling proteins and results in siRNAusing RAD6 of Downregulation chemoresistance. and recurrence cancer to contributes which lines, cell OC in SOX2 and after carboplatin therapy. RAD6 upregulation also promotes increased expression of cancer stem cell signaling proteins ALDH1A1 FANCD2,as DNAsuch in γH2AX proteins increase and an response RAD18, damage to PCNA, leads overexpression RAD6 that promote stemcellcharacteristics, chemoresistance to platinum drugs, andleadstopoorprognosisin OCpatients. Our datashow jugating enzyme, is significantly overexpressed in ovarian tumors. RAD6 is associated with increased proliferation, tumorigenesis, ever, ~70% of OC patients relapse and develop chemoresistance to platinum therapy. Studies show that RAD6, an How- E2 carboplatin). ubiquitin-con as (such chemotherapy platinum-based by followed surgery debulking involves treatment first-line the OC, In Ovarian cancer (OC) is one of the most lethal gynecological malignancies and fifth leading cause of cancer-related deaths in women. bock, TX, USA. Center,Cancer Texas Southwest and Center,Gynecology Lub- TechSciences and Health Obstetrics University of Department (2) 79430-6540, USA. TX, Lubbock, Street, 4th Biochemistry,Center,3601 and TexasSciences Biology Health TechCell University of Department (1) Tasmin R.Omy(1),ShirishaJonnalagaddaMarkReedy(2)andKomaraiah Palle(1) RAD6 inhibitionattenuatesDNA repair andstemcellsignalingovercomes acquired chemoresistance inovariancancer GS1-2 OMY, TASMIN RAHMAN School: GraduateSchoolofBiomedicalSciences the survivalofGV inMSVFasitisforrecoveryofGV fromthevagina. for critical 5 is 4 to from pH the of shift the that and media laboratory respective their in that from different significantly is MSVF in GVLP and of growth the conditions, pH two these at that, suggest results These h. 96 and 72 by 106 to rose and h 48 at 104 to at 48, 72, and 96 h. In contrast, GV failed to grow in MSVF-pH4; while in MSVF-pH5, GV CFU dropped slightly at 24 h, returned decreased to 102 at 24 h, with no recoverable CFU at 48 h and after; in NYC- pH5, the CFU increased to 105 at 24 h and held at 107 under both pH conditions, LP CFU increased to 106 at 24 h and remained constant to 96 h. In NYC-pH4, the initial inoculum of GV MSVF in contrast, In h. 96 at 105 and 72 at 106 to declined and h 24 at LP108 MRS-pH5, to in increased h; CFU 96 at recovered pH 5 at 24, 48, 72, and 96 h post inoculum. In MRS-pH4, LP CFU dropped slightly at 24 and 48 h, and to 102 at72 h with no CFU (CFU), we compared the growth of LP and GV individually in MSVF with growth in MRS and NYC, respectively, at both pH 4 and MSVF is more that suitable to assess hypothesized the potential interaction environment. We between LP vaginal and GV. the resembles Using an closely initial inoculum of more 104 colony forming (MSVF) unit fluid vaginal simulating medium the However, vaginalis (GV) are often grown in de Man, Rogosa and Sharpe medium (MRS) and New York City III medium (NYC), respectively. teraction between these bacteria and their relationship to the pH change is not known. Lactobacillus plantarum (LP) and Gardnerella with BV, a rise in vaginal pH to ≥4.5 is accompanied by a population shift diagnosed in women in that, Lactobacillus shown have and studies previous Gardnerella yet unknown, species. still is BV of The cause exact potential The diseases. transmitted sexually in- of risk increased with associated is age, reproductive of women in infection vaginal common most the (BV), vaginosis Bacterial Stephany Navarro,Jane A. Colmer-Hamood, Gary Ventolini, and Abdul N.Hamood vaginal environment the mimics closely which fluid, Gardnerellavaginal and simulating growthLactobacillus medium the of in Characterizing species GS1-2 NAVARRO, STEPHANY gy withcarboplatin. - 27 ABSTRACTS geted therapy. Renal cell carcinoma (RCC) is the most prevalent type of malignant kidney cancer in RCC is resistant to showing traditional treatments only the 4-5% suc- Additionally, U.S rate below 20% if diagnosed at an advanced stage. with a maximum 5-year survival cess rates for chemotherapy and RCC Fortunately, radiotherapy. has shown responsiveness to However, immunotherapy. current immunotherapies, such as PD-1 blockading can antibody, result in severe systemic adverse effects, underlining a need for a more focused approach that antigensspecifically tumor-associated expressed targets by RCC such as CD105. Both the RCC tumor cells and its vasculature express CD105, making it a unique therapeutic target. While its role is well-characterized in angiogenesis, its impact on the tumor phenotype a is However, previous still study unclear. utilizing human RCC cells in vitro did find that CD105 likely potentiates The tumor goal stem-cell of behavior our and resistance project, therefore, to is chemotherapy. to determine role of CD105 in tumor cell growth and metastasis utilizing a syngeneic murine RCC tumor model, Renca, and to determine if we can that suggests data preliminary our fact, In immunotherapy. CTL-based a with tumors RCC CD105-expressing target therapeutically CD105 mediates Renca tumor cell metastatic potential and that therapeutic targeting of CD105 can reduce RCC tumor growth in the and model, mouse syngenetic a in growth tumors RCC in CD105 of role the characterize further to continuing are Studies vivo. tar importance of tumor cell-specific CD105 expression in the efficacy of CD105 Hannah Seah, Min Xie, Britney Reese, Mariam Oladejo, Vikram Mavinkurve, and Laurence M. Wood Mavinkurve, and Laurence M. Vikram Mariam Oladejo, Hannah Seah, Min Xie, Britney Reese, School: Graduate School of Biomedical Sciences - CD105 in Renal Cell Carci of CD105 in a Murine Model of Renal Cell Carcinoma and Characterization Therapeutic Targeting noma GS1-2 SEAH, HANNAH School: Graduate School of Biomedical Sciences School: Graduate School of Biomedical Chronic pain is a prevalent national healthcare issue, yet many knowledge gaps exist in regard to brain mechanisms of Al- pain. though alterations in neuroimmune signaling have been linked to chronic pain, neuroinflammation in the brain in the development of a pathological pain state and underlying molecular mechanisms remain to The be amygdala is determined. a limbic brain center box group mobility High modulation. pain and pain of dimensions emotional-affective the in component key a as emerged has that signal- TLR4/NF-κB the via amygdala the in neuroinflammation to linked been has that molecule proinflammatory a is (HMGB1) 1 rats male adult from amygdala the dissected we Here explored. been not has mechanism pain amygdala in role its but pathway, ing four weeks after inducing neuropathic pain via the well-established spinal nerve ligation (SNL) model, and sequencing RNA was used to obtain gene expression profiles from this regionTissues (transcriptomics). from rats SNL showed increased expression of within activation HMGB1 that hypothesis the tested we Therefore, surgery. sham underwent who those to compared when HMGB1 the amygdala contributes to the transition from normal to a chronic pain state, and that pharmacological inhibition of HMGB1 can measured were behaviors depression-like and anxiety- and responses, emotional thresholds, Sensory behaviors. pain-related reduce and in sham SNL rats before and after the administration of HMGB1 inhibitors. Our findings identified HMGB1 as a useful target for pain inhibition, providing a better understanding of neuroinflammatory mechanisms within the amygdala and yielding novel neuropathic pain management. for chronic therapeutic targets Peyton Presto, Christine Prater, Igor Ponomarev, Volker Neugebauer Volker Igor Ponomarev, Christine Prater, Peyton Presto, GS1-2 PRESTO, PEYTON PRESTO, GS1-2 pain management in neuropathic target a potential therapeutic HMGB1 as

ABSTRACTS 28 School: GraduateSchoolofBiomedical Sciences clinically toincreasetransplant viabilityinpatients. cade. Data gained from these experiments will be critical in determining the mechanism of SCimmune privilege and will translate cas- complement the block SCs which at points the confirm to anaphylatoxins complement of concentrations the measuring with vitro. We intend to investigate CRPs producedbySCsandconfirmtheir roleinSC-mediated complement inhibition invivo,along (DAF), CD59, and clusterin. Preliminary data from our lab factor suggests that decay-accelerating MCP (MCP), and DAF protein are critical cofactor to the membrane survival inhibitor,of porcine C1 SCs in including cascade complement the inhibit that (CRP) proteins regulatory complement of levels elevated produce SCs environment. privileged immune an creating by drugs suppressive that testicles mammalian protects spermatogonia in from the immune system, found survive xenotransplantation and hyperacute type rejection without the cell use of immune- a (SCs), cells Sertoli cell. target the of lysis or opsonization either with culminating enzymes proteolytic of series a is Complement system. complement the of activation antibody by primarily occurs tissue planted xenotrans- of rejection Hyperacute failure. organ and infections, of severity and incidence increased pressure, blood elevated ing drugs are prescribed to prolong transplant survival. As these drugs are administered long-term, they cause harsh side effects includ offers an endless supply of tissue, yet rejection of xenografts is a concern even when using transgenic animals. Immunosuppressive humans, to tissue porcine transplanting as such Xenotransplantation, performed. actually were transplants 35,000 under just while Diabetes Mellitus, and by saving lives, as in the case of organ failure. In 2017 there were over 117,000 patients awaiting transplants Transplantation is used to treat many conditions by improving quality of patient life, as in pancreatic islet transplants to treat Type I Rachel L. Washburn, GurvinderKaur, JannetteM.Dufour Sertoli cellinhibitionofthecomplementsystemmayimprove xenograftviability GS1-2 WASHBURN, RACHEL School: GraduateSchoolofBiomedicalSciences for AUD. Conclusion: CMMs that reduce antimicrobial action and retain efficacy to reduce ethanol consumption may be useful as a treatment increase ofchainlength. Results: A series of 4 CMM analogs were found to have loss of antimicrobial action and reduction of ethanol consumption vary with utilized inbothfemaleandmaleC57BL/6Jmice. culture. To evaluate ethanol and/or water consumption, Drinking-in-the-Dark (DID) and Two Bottle Choice (2BC) procedures were cell coli E. in analogs CMM our of efficacy antibacterial the assess to used were assays (CFU) unit forming colony and (ZOI) tion troscopy and Liquid Chromatography-Mass Spectrometry after initial identification via Thin-layer Chromatography. spec- Resonance Zone Magnetic of Nuclear inhibi via done was analogs (CMM) minocycline modified chemically Verification the Methods: of anti-inflammatory, neuroprotective,andimmunomodulatoryproperties. desirable the maintain yet of ribosome, the regions to binding key from it to preventing by length properties antimicrobial its increasing remove would of minocycline chains carbon adding that hypothesized We microbiota. gut healthy on effects antibiotic strong its to due limited been have diseases non-infectious in minocycline of benefits Therapeutic (AUD). Disorder Use Alcohol including disorders, such other in efficacy for tested been has it why is which properties, immunomodulatory and neuroprotective, anti-inflammatory,has also minocycline properties, antibiotic for essential ribosome is bacterial binding this the While synthesis. to protein inhibiting binding and of result a as properties antibiotic has tetracycline, of derivative a Minocycline, Background: W. Reid,andSusanE.Bergeson Colton Sniegowski, Benjamin Jackson, Joshua Willms, Xiaobo Liu, Maritza Brito, William Kariampuzha, Madhu Narasimhan, Ted Targeted CarbonChainLengthModifications AlterMinocyclineTherapeuticProperties toReduce AlcoholConsumption GS1-2 SNIEGOWSKI, COLTON - - 29 ABSTRACTS . Testing this hypothesis is the goal of our project. Testing . GRADUATE STUDENTS 3+ YEARS GRADUATE The classical ketogenic diet (KD) was developed to treat intractable epilepsy in the 1920s and is defined by a ratio of 4:1grams orof 3:1 fat to combined grams of carbohydrate and protein. A modified and currently popular version ofcarbohydrate intake theof KD<50-100 isgrams per definedday as and elevated blood levels of beta-hydroxybutyrate (BHB, a ketone) an is BHB of cancer. including >0.5 diseases, many for treatment effective an as proposed been has KD This mM). 0.1 levels, (normal mM agonist for the G-protein-coupled receptor GPR109A. Previously published reports from our lab func- have shown that GPR109A tions as a tumor suppressor in colon and in mammary gland, which can be activated by niacin. The hypothesis is that a GPR109A expres- GPR109A of level the between correlation direct a showing data omics TCGA by strengthened further is suppressor tumor this activating by suppressor tumor a as function also could BHB Therefore, patients. the of survival overall the and tumors in sion find that the niacin administered orallyWe increase the time of onsetreceptor. of breast cancer in a spontaneous, transgenic breast of time at weight and burden tumor lower a toward trends with time, over load tumor the as well as mice, C57Bl/6J in model cancer oxida- mitochondrial for a substrate also is BHB benefit. less shows chow) standard to (compared diet ketogenic the while sacrifice, which could promote tumor growth, possibly explaining this niacin paradoxical does outcome. Interestingly, ATP, tion to generate mice that find we unexpectedly, Quite models. cancer colon and breast in molecule energy-generating an as role direct any have not with knockout GPR109A show decreased tumor volumes in two xenograft hypothesize models. that We niacin supplement might provide a better strategy than a KD for prevention of breast cancer Kevin Bass, Sabarish Ramachandran, and Vadivel Ganapathy Vadivel Kevin Bass, Sabarish Ramachandran, and GPR109A for Prevention/Treatment of Breast Cancer: Ketogenic Diet versus Niacin Cancer: Ketogenic Diet of Breast for Prevention/Treatment GPR109A School: Graduate School of Biomedical Sciences School: Graduate School of Biomedical Sciences School: Graduate School of Biomedical Conclusion— Structure-function correlation allowed the design and production of new CMMs, which remains ongoing. The results The ongoing. remains which CMMs, new of production and design the allowed correlation Structure-function Conclusion— toxicology. and efficacy pharmacological for tests additional undergo now will that compounds lead three of determination the to led AUD with CMMs. of The findings show promise for treatment Results—A) Five CMM compounds both lost their antimicrobial activity and significantly reducedethanol consumption, B) one CMM reduced ethanol consumption, but still needs to and be C) tested eight for CMM antimicrobial compounds activity, retained D) One CMM was toxic. some antimicrobial activity. Methods—Fifteen chemically modified minocycline (CMM) analogs were made. Nuclear Magnetic Resonance spectroscopy and Zone compounds. CMM the of purity and structure chemical the validate to used were Spectrometry Chromatography–Mass Liquid and (DID) Drinking-In-the-Dark action. antimicrobial of loss the evaluate to used were assays unit forming colony and inhibition of Bottle Two Choice (2BC) paradigms were used to measure ethanol consumption in adult female and male C57BL/6J mice. Mice of ethanol drinking. or vehicle 20 h prior to a 4 h period were administered CMM Background—Alcohol Background—Alcohol Use Disorder (AUD) is the third leading cause of preventable morbidity in the United States, but remission. less than sustained achieve medications approved FDA currently the with intervention pharmacologic receive who patients of 20% AUD for use long-term but mice; in consumption ethanol reduce to known is antibiotic, an tetracycline, of derivative a Minocycline, carries the risk for generating antibiotic resistance and gastrointestinal hypothesize disturbance. that We targeted modifications to consumption. ethanol reduce to efficacy the improve and action antimicrobial the remove will minocycline of structure chemical the Joshua O. Willms, Benjamin Jackson, Joshua Colton Willms, O. Sniegowski, Xiaobo Kariampuzha, Liu, Myank Maritza Shastri, William Brito, Phat and Susan E. Bergeson Reid W. Ted Tran, GS1-2 WILLMS, JOSHUA WILLMS, GS1-2 Compounds Modified Minocycline by Chemically of Ethanol Consumption Reduction GS3+ BASS, KEVIN GS3+ BASS,

ABSTRACTS 30 pain processes. inflammatory in receptors opioid and cannabinoid influencing are changes hormonal these how evaluate to needed are studies ther Fur pain. inflammatory of modulation the in sex-hormones of role important the highlight action. This of mechanism sex-specific the well as demonstrate and SU-3327 of effect anti-inflammatory dose-dependent and sex the illustrate results Conclusions: These that thisanti-inflammatoryeffect ofSU-3327(1mg/kg)ismediatedbybothCB1and CB2cannabinoidreceptors. found and male in SU-3327 of mg/kg) (1 dose lower a evaluated we Therefore, effects. locomotor and hypothermia inducing was dose mg/kg). This 10 of (dose SU-3327 of effect anti-inflammatory this reverse to failed antagonists opioid-receptor as well as tor 1, 3, 10 and 30 mg/kg doses showed anti-inflammatory effects using the formalin test. Moreover, CB1 and CB2 cannabinoid recep- anti-inflammatory effect in female mice. In males, in the acute phase, 3, 10 and 30 mg/kg doses and in the inflammatory phase, 0.3, SU-3327 the reverse to failed antagonists receptor opioid and receptor cannabinoid receptor.CB1 cannabinoid CB2 by mediated was effect anti-inflammatory This test. formalin the of phases inflammatory and acute the both in anti-inflammatory were mg/kg 30 and 10 only females, in Indeed, dose-dependent. and sex is SU-3327 of effect anti-inflammatory the found study Our Results: followed byBonferroniposthoctestsusingSPSSstatistical software(version21.0). (ANOVA)variance one-way of or analysis ANOVAmeasures using repeated analyzed for were Data ip). mg/kg 10 appropriate as effect by administration of AM251 (3 mg/kg ip), AM630 (3 mg/kg ip) or Naloxone (10 mg/kg ip) 30 minutes prior to SU-3327 (1 or formalin intraplantar) in male and female wild-type mice. We also investigated the mechanisms of action of this anti-inflammatory anti-inflammatory effect. Different (0.3, 1, 3, 10, this 30 mg/kg ip) dosesin of SU-3327 werereceptors evaluated in theµ-opoid formalin test (10and µl of 2.5CB2 % CB1, of involvement potential the evaluate also will we Morevover, dose-dependent. and sex is effects antinociceptive JNK whether mice male and female wild-type in assess to is work current our of Methods: objective The been investigatedandremainselusiveaswhethersexhormonesareinvolved. not have processes pain inflammatory in effect analgesic JNK underlying mechanisms the of understanding complete However,a tory has demonstrated the antinociceptive properties of c-Jun N-terminal kinase (JNK) inhibitor (SP600125) in inflammatory pain. labora Our imperative. are sex-differences potential consideration into taking while pain inflammatory against therapies targeted novel of development The models. pain inflammatory in differences sex demonstrated recently has group Our debated. been has Introduction: Cannabinoids are known to alleviate inflammatory pain in preclinical models. However their effectiveness in the clinic Henry Blanton, Agata Pietrzak,MelissaMchann, JenniferBrelsfoar, JoséeGuindon involving CB1and/orCB2cannabinoidreceptors of action mechanisms sex-specific shows and dose-dependent and sex are inhibitor a JNK SU-3327, of effects Anti-inflammatory GS3+ BLANTON, HENRY School: Texas Tech University gies toexploitbiofilm-targeting phageswhilecombattingtheeffectsofbiofilm-strengtheningphageproteins. P.within strate proteins therapeutic phage novel identify potentially to techniques microscopy and genetics using EPS aeruginosa temperature-responsive these of role the exploring function. further biofilm are the We in participating be potentially could which protein expression profiles. Our transcriptomic data also supports a temperature-based regulation mechanism for the phage proteins Using MALDI IMS, we have demonstrated that biofilms grown under different temperature conditions exhibit dramatically different pacts biofilmformation. im- that reactivation phage differential to contribute will host the into environment external the from transitions it as experiences to desiccation and certain antibiotics. We hypothesize that stress conditions associated with the temperature shifts that P. aeruginosa eradication by some phages whereas reactivation of other phages within its genome can contribute to a biofilm matrix that for targeted is be can tolerant that biofilms demonstrated aeruginosa have P. studies Previous form. biofilm relevant clinically its in growing Pseudomonas aeruginosa, an opportunistic pathogen is a serious threat due to its high level of antibiotic resistance, especially when conditions. stress to tolerance and surfaces to adherence biofilm in aids which matrix, (EPS) substance polymeric extracellular the Conversely, infections. some bacteriophages have recently been found to contribute certai - - - 31 ABSTRACTS - - - showed These re- The wound bed and margins were excised were excised margins The wound bed and School: Graduate School of Biomedical Sciences ated in situ in the proximity of the tumor cells. These peptides could serve as the substrates test for the PEPT1. To validity of this PEPT1 surprise, our To cancer. breast of models mouse transgenic spontaneous several in mRNA PEPT1 analyzed first we concept, representing tumors breast mouse in also and gland mammary normal in absent but mice, Tg MMTV-Neu to limited was expression PEPT1 mRNA PEPT1, we determined neu and oncogenic the between connection a possible investigate further To subtypes. other in human breast cancer cell lines encompassing three different As subtypes. with our findings in transgenic mice, PEPT1 was ex- pressed only in SK-BR-3 cells, a Her2+ breast cancer cell line. No PEPT1 expression was detected in the ER+ MCF-7 cell line or cancer, breast in Her2 and PEPT1 between connection molecular a demonstrate data These line. cell MDA-MB-231 triple-negative where PEPT1 might contribute to amino acid nutrition of tumor cells. Lactate and protons accumulate in the tumor microenvironment as a result of aerobic glycolysis in tumor cells. The resultant acidic resultant The cells. tumor in glycolysis aerobic of result a as microenvironment tumor the in accumulate protons and Lactate environment creates an inwardly directed H+ gradient across the tumor cell plasma hypothesized membrane. We that tumor cells their meet effectively to transporters nutrient H+-coupled fuel to force driving a as gradient H+ occurring naturally this exploit can nutritional needs. One such transporter is the peptide transporter PEPT1 (SLC15A1). Expression of PEPT1 is normally limited to published no are there now Until cancers. colon and pancreatic in expressed highly be to found been recently has but intestine small extracellular the in collagen because tumors growing rapidly for relevant very be would PEPT1 cancer. breast in PEPT1 on reports breast cancer invasion of bone requires break- metastatic Additionally, matrix has to be digested to make room for tumors to grow. gener be would peptides metalloproteinases, tumor-secreted by degraded are proteins matrix extracellular When collagen. of down School: Texas Tech University Tech Texas School: Ganapathy Vadivel Brown, Sabarish Ramachandran, Timothy cal observations. On day 1, all treatments showed neutrophilic infiltrate (PMN) and edema throughout the wound beds, while a infiltrate (PMN) and edema throughout day 1, all treatments showed neutrophilic cal observations. On was substantial within the By day 3, the level of epidermal hyperplasia of the BTW. in the wound margin blood clot had formed and throughout the wound beds of UTW PMN infiltrate and edema were present and PTW. minimal in UTW but of BTW margin and PTW On day 7, UTW and PMNs present throughout the wound. showed the beginning of crust formation while BTW PTW, and a compact crust formation across the wound bed. In contrast, BTW revealed the presence of epidermal hyperplasia the wound bed, and formation of blood crust formation with PMN infiltrate across advanced epidermal hyperplasia, organized On all days, BX eliminated S. aureus from the wound bed (6-log reduction). vessels indicative of neovascularization. the healing of infected wounds and eliminated the wound bioburden. sults suggest that application of BX accelerated effect and Warburg to tumor microenvironment cancer and its relation transporter PEPT1 in breast of the peptide Expression GS3+ BROWN, TIMOTHY GS3+ BROWN, vents or slows wound healing. Previously, we showed that BlastX wound gel (BX), eliminates S. aureus bioburden from an that BlastX wound gel (BX), eliminates we showed healing. Previously, vents or slows wound model of wound infection, promote wound healing. Using the murine its antimicrobial effect, BX may infected wound. Besides wounds were generated, infected wound. Full-thickness of BX on the healing of a S. aureus-infected we examined the influence polyethylene glycol base wound, UTW), gauze coated with h, and covered with sterile gauze (untreated with S. aureus for 8 (BX-treated wound, BTW). PTW), or gauze coated with BX gel (PEG-treated wound, with H&E for general histologi were processed, sectioned, and stained Formalin-fixed tissues at 1, 3, and 7 days post-treatment. Chronic wounds, which include pressure ulcers and diabetic foot ulcers, affect approximately 6.5 million persons with a high 6.5 million affect approximately diabetic foot ulcers, pressure ulcers and which include Chronic wounds, wounds, pre from infected chronic commonly isolated one of the bacteria aureus, for treatment. Staphylococcus annual cost Kayla Bounds1, Vivian Yim2, Jane Colmer-Hamood2,3, Matthew Myantti4, Randall Jeter1, and Abdul Hamood 3,5 Abdul Hamood and Randall Jeter1, Matthew Myantti4, Jane Colmer-Hamood2,3, Yim2, Vivian Kayla Bounds1, GS3+ BOUNDS, KAYLA BOUNDS, GS3+ infected wound in an S. aureus process the wound healing gel influences BlastX wound

ABSTRACTS 32 School: GraduateSchoolofBiomedical Sciences The translationalimplications ofthisstudywillbediscussed. hypoplasia. spleen and failure BM aGVHD-mediated to resistant are mice outbred diverse Genetically Conclusions: controls. CC circulating leukocytes, erythrocytes or platelets. BM- andspleen-associated cell numbers werenotreduced when compared their hematocrit, in reductions significant post no and days Ttransfer 25-30 cell at loss weight no or little induced mice outbred CD1 or CC irradiated sub-lethally into Bl6 Tcells of transfer adoptive contrast, In liver,colon. lungs, and the skin in present was aGVHD be dramatically reduced in these mice. Histopathological inspection confirmed severe hypocellularity in BM and spleen whereas no erythrocytes when compared to their syngeneic controls (BM12→BM12). Total cell numbers in BM and spleen were also found to that was associated with dramatic reductions in hematocrit as well as significant decreases in circulating granulocytes, platelets and post days T20 transfer at cell (25%) loss weight marked induced Bl6 recipients allogeneic BM12 Tof into transfer cells Adoptive irradiated Bl6-H2-Ab1bm12 (BM12) recipients (Bl6→BM12) or into Collaborative Cross (CC) or CD1 outbred recipients. Results: sub-lethally into (i.p.) injected b.w.)were cells/g T (20,000 cells T CD4+ (Bl6) C57Bl6 Methods: hypoplasia. spleen and failure tissue inflammation and injury in inbred vs. outbred mice using a well-characterized model of aGVHD-mediated bone marrow (BM) compare and Quantify Objective: populations. human diverse genetically for surrogates as mice inbred use the is treatment patient of choice for modeling aGVHD. One aspect of these mouse models that may limit translation of promising therapeutic strategies to potentially lethal, multi-organ inflammatory disorder called acute graft versus host disease (aGVHD). Mice are the primary animal a of development the is malignancies hematological treat Ato transplantation cell stem hematopoietic of use with limitation major Josue Enriquez,BrianyellMcDanielMims,KathrynFurrandMatthewB.Grisham Susceptibility ofgeneticallydiverseoutbred micetoacutegraft vs.hostdisease GS3+ ENRIQUEZ, JOSUE School: Texas Tech University ences P. aeruginosabysignificantlyalteringtheexpressionofdifferentvirulencegenes. influ- malonate source, carbon a sole as that, suggest results MexXY-OprM These pump. of efflux function the with associated is Malonate also increased PA14 sensitivity to norfloxacin, a fluroquinolone antibiotic. In P. aeruginosa, resistance to fluroquinolones genes. biosynthesis polysaccharide Pel biofilm-associated the of expression and formation biofilm reduced malonate addition, In by production PA14. pyoverdine reduced significantly but PQS and catalase, pyocyanin, of production the enhanced significantly lacZ-transcriptional fusion analysis, we confirmed the effect of malonate on some of those genes. As a sole carbon source, malonate mexXY-oprM. pump efflux Using the and pyoverdine, of synthesis secretion, III type in involved genes of expression re- the pressed malonate In contrast, mexPQ-opmE. and mexGHI-opmD pumps efflux the and synthesis, flagellum production, cyanide and pyocyanin biosynthesis, (PQS) signal quinolone Pseudomonas in involved those including genes, virulence several of expression the induced Malonate genes. PA14 3,436 of of growth expression the the GM9, regulated in differentially growth MM9 its in with supplemented with either malonate (MM9) or glycerol (GM9) as a sole carbon source on the expression of PA14 genes. Compared influ- source, carbon sole a ences the expression of PA14 as virulence genes. used Using RNA-seq analysis, we examined the effect of growth in M9 minimal medium if malonate, that hypothesized fatty unknown. We of is expression biosynthesis gene the virulence in influences involved acids, acid dicarboxylic a malonate, Whether operon. utilization malonate the constituting those significantly influenced the expression of more than 250 genes. Among the genes whose expression was significantly induced were WeUCBPP-PA14strain aeruginosa Pseudomonas of growth the that showed recently (PA14) patients trauma from blood whole in TTUHSC Surgery, of 5Department TTU; College, 4Honors MolecularMicrobiol TTUHSC; Education, and Medical of 3Department ofImmunology TX; Lubbock, TTUHSC, ogy, TX;2Department TTU, Lubbock, Sciences, ofBiological 1Department Affiliation: Moamen M.Elmassry1,JaneColmer-Hamood2,3, MichaelSanFrancisco1,4,Catherine Wakeman1, Abdul Hamood2,5 Malonate metabolismregulates quorumsensing,virulencefactors,andantibioticresistance ofPseudomonasaeruginosa GS3+ ELMASSRY, MOAMEN - 33 ABSTRACTS - School: Graduate School of Biomedical Sciences Brain slice electrophysiology was used to measure the effects of a KOR antagonist (Nor-Binaltorphimine, nor-BNI) on CRF-CeA neurons, which can be visualized in brain slices from transgenic was Crf-Cre injected rats. AAV5-ChR2-CaMKII-eYFP into the neurons, because LPB input pro- synaptic input lateral parabrachial to area CeA (LPB) to allow optical activation of glutamatergic later weeks 3 followed days 7 for priming morphine by induced was model FPS The amygdala. the to information nociceptive vides by 1 hour of restraint stress on 2 consecutive days. Whole-cell patch-clamp recordings of frequency, IPSC neurons CRF-CeA miniature found and that spontaneous as nor-BNI well as (IPSCs) currents synaptic inhibitory glutamate-driven LPB-evoked increased FPS of model rodent a in signaling KOR of blockade that suggest data The excitability. neuronal decreasing while amplitude, not but neurons through a presynaptic mechanism of action. restores synaptic inhibition of CRF-CeA Functional pain syndrome (FPS) is defined as a condition in which the pain cannot be attributed to Mechanisms tissue pathology. of FPS remain to be determined, but these conditions are typically triggered by stress, which can create a chronic pain condition. and behaviors emotional-affective to linked been have amygdala the in receptor CRF1 its and (CRF) factor releasing Corticotropin pain modulation. The amygdala is also a major site of opioid receptors. The central nucleus (KOR). of receptor the opioid amygdala (CeA), kappa in G_i/o-coupled particular, the of expression of levels high exhibits and output, amygdala of site major a as serves Based clear. not are mechanisms the but effects, adverse have can agonists or dynorphin, ligand, endogenous its by activation KOR on preliminary data, we hypothesize that KOR activation inhibits synaptic neurons. inhibition Here of we CRF tested CeA the hy- in a rat model of FPS. pothesis that blockade of KOR signaling restores inhibitory control of CRF neurons Matthew Hein, Guangchen Ji, Edita Navratilova, Frank Porreca, Volker Neugebauer Volker Frank Porreca, Matthew Hein, Guangchen Ji, Edita Navratilova, Kappa opioid receptor blockade restores inhibition of amygda CRF neurons in a model of functional pain inhibition of amygda CRF neurons restores blockade Kappa opioid receptor GS3+ HEIN, MATTHEW GS3+ HEIN, School: Graduate School of Biomedical Sciences School: Graduate School of Biomedical ance to reactive oxygen species and show significant difference in metabolomic profile. In addition, our preliminary results reveal the difference in lipids profile in drug resistant cells suggesting that specific changes in plasma membrane couldSbV contribute to resistance in Leishmania parasites. The leishmaniasis is one of the major tropical disease that affects about twelve million people worldwide with estimated two million two estimated with worldwide people million twelve about affects that disease tropical major the of one is leishmaniasis The new cases per It year. is caused by Leishmania parasites, unicellular protozoa that are able to infect human and other vertebrates. During the last 60 years, the pentavalent antimonials (SbV) have been used as a major decrease treatment. in However, it the was drug a efficacysignificant associated with development ofdisease the resistanceimprove to resistance ofdrug Leishmania theof mechanism clinicalmolecular the Leishmaniaunderstand to isolatesneed urgent toan demanding antimonialsresistance) (SbV- We parasites. Leishmania in SbV to resistance of mechanism molecular the elucidate to is project this of goal major The treatment. hypothesized that drug resistance in Leishmania parasites is associated with differential gene expression caused by drug treatment. The Leishmania species lacks transcriptional regulation and gene expression is mostly regulated on translational level thus mak- ing challenging the identification of the potential gene products involved in drug resistance by conducting transcriptome analysis. Therefore, in this project we combined methods to study translation in Leishmania with different phenotypic studies of drug resis- profiling polysomal employed we isolates resistant drug the in translated preferably are that mRNAs identify to First, parasites. tant identify to allows method This cells. resistant drug and control of fractions translated highly of sequencing RNA deep and technique toler higher have parasites resistant drug that showed we time, same the At translation. in engaged efficiently mRNAs of set full the Sneider Alexander Gutierrez Guarnizo, Elena B. Tikhonova, Elkin Galeano, Carlos Muskus , Zemfira N. Karamysheva, Andrey Elkin L. Galeano, Carlos Muskus Alexander Gutierrez , Tikhonova, Guarnizo, ZemfiraElena N. B. Karamysheva, Sneider Karamyshev GS3+ GUITERREZ, SNEIDER GUITERREZ, GS3+ Parasites Resistance in Leishmania Antimony Drug of Mechanism

ABSTRACTS 34 School: Graduate SchoolofBiomedicalSciences could berepurposedasanovel andtargeted single-agentchemo-immunotherapy forpancreaticcancer. drug FDA-approved this that and Carbidopa for target molecular novel a is IDO1 and SLC6A14 Wethat Carbidopa. conclude by the targets. Additionally, we are also trying to understand the molecular mechanisms responsible for SLC6A14 and IDO1 inhibition or both target asingle of either presence in the of Carbidopa efficacy the interrogate and findings vitro in our extrapolate to trying are we model animal Currently,vivo growth. cancer in pancreatic using of attenuation thereby and mTORC1signaling of hibition in- deprivation, acid amino to led SLC6A14 of inhibition induced Carbidopa that demonstrated experiments Further level. protein mRNA the at both expression, and IDO1 and SLC6A14 inhibited significantly Totreatment Carbidopa that found we surprise, our Westernblotting. and PCR, Real-time a performed and points time varying for Carbidopa mM 20 CFPAC-1)with and Capan-1, (BxPC-3, lines inhibitor.cell IDO1 cancer an We pancreatic nor treated blocker then SLC6A14 a neither be to Carbidopa showed experiments the both surprisingly (LC/MS/MS); spectrometry chromatography/mass liquid a also and uptake glycine radiolabeled a highly potent blocker and inhibitor of SLC6A14 and IDO1, respectively. To validate our computational findings, we performed a tor) implicated that it could target both SLC6A14 and IDO1. Interestingly, our computational modelling suggested Carbidopa to be antiparkinsonian drug L-DOPA. Carbidopa’s structural similarity the to of a-MLTefficacy therapeutic the (SLC6A14 potentiate blocker) and to phenylhydrazine used (IDO1 is inhibi and decarboxylase acid amino aromatic of inhibitor an is property.Carbidopa could target both SLC6A14 and IDO1. Recently, our laboratory that identified Carbidopa, andrug FDA-approved drug to haveFDA-approved an anticancer an identify to was here aim our SLC6A14, of blocker potent a-MLTa Though is PDAC. treat to agent, immune system.Ourquestionhereis,canwetargetin theimmune cells,withasingle bothSLC6A14inthetumorcellsandIDO1 the evade to cells tumor enables and cells, T of proliferation suppresses surroundings, the in tryptophan depletes DCs in activity increased its (Trp)-catabolizingenzyme; tryptophan a is IDO1 immune-suppression. to contributes This (IDO1). 1 3-dioxygenase indoleamine-2, higher express nodes tumor-draininglymph and (DCs) cells dendritic antigen-presenting the wherein environment immune-suppressive an by characterized also is PDAC PDAC. for target therapeutic good a be to SLC6A14 demonstrated have tory has identified SLC6A14 to be significantly upregulated in PDAC. Using alpha-methyl-L-tryptophan (a-MLT)labora as a blocker, we Our digits. single in only rate survival a with cancers all of lethal most the is (PDAC) adenocarcinoma ductal Pancreatic Ksenija Koracand Yangzom D.Bhutia Pancreatic CancerandCarbidopa GS3+ KORAC, KSENIJA School: GraduateSchoolofBiomedicalSciences co-translational interactingpartnersofaSyniskeyindiscerningthecausesaggregationanddevelopingtherapiesagainstit. Determining translation. of level the at regulation aSyn in involved SRPis targetingfactor the that suggest data Our aSyn. mutant others. and Wefactors, ing SRP mRNAthe both of affects depletion SRP54, that subunit, found of expression WT protein and and chaperonin Hsp90, and Hsp70 TRiC/CCT,chaperones (SRP), particle recognition signal translation- during chain nascent modify- for both wild-type and mutated aSyn. The potential candidates include proteins that are associated with the ribosome or polypeptide translational interaction events take place. The major goal of this study is to identify possible interacting partners during translation co- early where protein, the of part first the within present all are and A53T) G51D, (A30P,A53E, H50Q, mutations E46K, aSyn PD). (sporadic partners interacting the in defects by or PD) (familial itself aSyn in mutation a to due be can partners interacting of alteration this PD, In disease. causing aggregation, and misfolding its to leads translation during partners interacting aSyn of tions altera that is hypothesis Our diseases. human many for cause common a is aggregation and misfolding Protein (aSyn). Synuclein acterized by the presence of intracellular inclusions known as Lewy bodies. Lewy bodies are composed of aggregated protein alpha- the United States by the CDC. PD is part of a class of neurodegenerative diseases, referred to as Synucleinopathies, which are char in death of cause leading 14th the as rated is and disease neurodegenerative common most second the is Parkinson’s(PD) disease Sarah M.Hernandez,KristenR.Baca,ElenaB. Tikhonova, Andrey L.Karamyshev Potential Targets inParkinson’s DiseaseTreatment: UncoveringNewInteractingPartnersofalpha-Synuclein GS3+ HERNANDEZ, SAR - - - - 35 ABSTRACTS - - School: Graduate School of Biomedical Sciences can alone. The constitutive activation of ATM/ATR kinases together with p53 LOF found in ALT cancers results in a high sensitivity high a in results cancers ALT in found LOF p53 with together kinases ATM/ATR of activation constitutive The alone. can APR-246. to restoring p53 function with Most cancers proliferate by activating telomerase (TA+), while 15% of cancers employ the ALT mechanism. ALT has been associ- ALT mechanism. ALT while 15% of cancers employ the Most telomerase (TA+), cancers proliferate by activating kinase, ATM that showed We survival. poor very and (p53LOF), loss-of-function p53 agents, damaging DNA to resistance with ated which activates functional p53, is constitutively activated in cell ALT lines (CLs) p53LOF CLs were significantly and ALT, PDXs. cancers APR-246. to p53 We reactivation hypothesized by ALT would selectively that sensitize ATM constitutive activation of phos- (p<0.005) higher observed We comparators. p53LOF TA+ to relative agents DNA-damaging to sensitive less (p<0.0001) kinases (involved phorylation in of ATM/ATR DNA-damage p53LOF signaling) relative CLs in ALT to CLs. ALT, showed TA+ TA+significantly p53LOF higher CLs. cytotoxicity Induc- in response APR-246 to (p<0.0001) the compared p53 to reactivator activation) ATM blocks that protein shelterin (a TRF2 dominant-negative using CL p53LOF TA+, a in dysfunction telomere of tion APR-246 kinase antagonized ATR or ATM APR-246 and (p<0.01). sensitized Chemical the inhibition cells of to ATM activated in ALT CLs with a mean 2.3-fold increase in APR-246 IC50 (p<0.0001). CLs APR-246 treated Knockdown showed with p53 ALT phosphorylation and APR-246 induction of cytotoxicity. of the kinase ATM downstream p53 targets similarly antagonized p21 and APR-246 NOXA. enhanced the cytotoxicity of irinotecan neuroblastoma, (as CLs SN38) in ALT ALT in vitro significantly more than five seen of in (EFS) survival event-free increased (p<0.01) significantly APR-246 (p<0.001). CLs p53LOF TA+, complete a hit to (28/31) mice most caused combined APR-246+irinotecan while CDXs/PDXs lymphoma and rhabdomyosarcoma TA+, p53LOF PDXs relative to irinote APR-246+irinotecan had 2 no significant effect (p=0.4) on EFS in response (p<0.0001). Shawn Macha , Balakrishna Koneru, Cody Eslinger, Jonas Nance, Kristyn Mccoy, Charles Zhu, C. Patrick Reynolds Nance, Kristyn Mccoy, Jonas Eslinger, Shawn Macha , Balakrishna Koneru, Cody APR-246, which Restores p53 Function, is Highly Active against Alternative Lengthening of Telomere (ALT) Cell Lines and PDXs (ALT) of Telomere Alternative Lengthening Active against p53 Function, is Highly APR-246, which Restores GS3+ MACHA, SHAWN GS3+ MACHA, We are using Using Sinclair a mini-pigs within-subject in experimental a 2BC paradigm until they criteria meet currently. We DSM-V design, all behavioral tests are done before, during and after the The development. sucrose preference test will be used to measure depression. Craving behavior will be tested by increased alcohol consumption after a period of will withdrawal. use We the mea Sciences School: Graduate School of Biomedical We previously developed a swine model using a Two Bucket Choice (2BC) paradigm in adult farm pigs. Ethanol consumption, pref- consumption, Ethanol pigs. farm adult in paradigm (2BC) Choice Bucket Two a using model swine a developed previously We pigs Farm model. rodent than AUD human to similar more was pig farm the that indicated elimination pharmacokinetic and erence, Minocy- reached intoxicating free-choice binge drinking levels and the development of a strong preference for ethanol over water. cline reduced preference for AUD These ethanol standard data better care. encouraged than us naltrexone, the to current develop a ability to complete brain imaging studies. of the limitation of housing and the mini-pig model because well as test ladder by tested be will alcohol to tolerance pharmacodynamic and Pharmacokinetic alcohol. access to work of surement as the lying to standing test and measurement of ethanol elimination over time. Overall symptoms of withdrawal will be evaluated based on the video. Body temperature, blood pressure, heart rate, and sleep cycle will be monitored for alcohol-related changes. Our hypothesis is that the model meets the DSM-V criteria. Our long-term goal is to test our newly developed drugs and the new promising compounds reported in the literature. Alcohol Use Disorder (AUD) is a chronic relapsing brain disease to characterized mice from AUD by for success translational compulsive limited a been has There alcohol using. not when use, state emotional negative a and loss intake, alcohol of control over model mini-pig a develop to is work proposed the of purpose The models. animal new develop to important is it therefore, humans; can be used as a translational tool. AUD that of Xiaobo Liu, Benjamin Jackson, Joshua Willms, Brittany Backus and Susan E. Bergeson Brittany Backus Willms, Joshua Benjamin Jackson, Xiaobo Liu, GS3+ LIU, XIAOBO LIU, GS3+ disorder of alcohol use of a mini-pig model Development

ABSTRACTS 36 School: GraduateSchoolofBiomedical Sciences hypoplasia intheabsenceofgut injury. levels compared to Asp-treated mice. Conclusions: Prophylactic IL-6 Abx serum treatment exacerbates in aGVHD-induced (~4-fold) BM failure increases and significant spleen with associated were alterations Abx-induced These mice. treated Asp to compared reductions in BM- and spleen-residing T cells and myeloid cells as well as circulating erythrocytes, platelets and hematocrit when significant and large in resulted also treatment Abx counterparts. Asp-treated their to compared when 20-fold than more by load bacterial colonic reduced with Abx mice transfer. allogeneic cell of post T Treatment days at 11-30 sacrifice to prior weight body cin for 7 days prior to and following T-cell transfer. Results: Both Asp- treated and Abx-treated mice lost approximately 20% of RAG1-/- mice received their water (ab libitum) containing aspartame (Asp) or an Abx cocktail containing Asp, neomycin and vancomy allogeneic (Balb/c) CD4+CD25- or T (Bl6) cells Syngeneic (5x106 cells) Methods: were damage. injected (i.p.) spleen into NK and cell-depleted BM Bl6 RAG1-/- aGVHD-induced recipients. Prior of to severity T and/or cell transfer, onset the affects (Abx) ics antibiot spectrum broad with decontamination gut prophylactic whether Determine Objective: pathogenesis. disease for required be not may bacteria intestinal that suggesting damage gut of absence the in develops hypoplasia splenic and failure (BM) marrow into the gut tissue where they activate donor T cells and initiate disease. However, we recently reported that aGVHD-induced bone products their and bacteria intestinal of translocation the enabling by aGVHD of severity and onset the potentiates and/or chemotherapy irradiation as such protocols conditioning toxic the by caused injury intestinal that majority suggest The studies transplantation. clinical preclinical/ cell of stem hematopoietic following complication major a is (aGVHD) disease host vs. graft Acute Brianyell McDanielMims,JosueEnriquez,KathrynFurr, andMatthewGrisham,Ph.D Prophylactic antibiotictreatment exacerbatesGraftvs.HostDisease-inducedbonemarrow failure andspleenhypoplasia GS3+ MCDANIEL MIMS, BRIANYELL School: GraduateSchoolofBiomedicalSciences could makethemvaluabletargets ofpharmacological agentsforpainrelief. which amygdala, the in processing pain of aspect different in involved be might mGluR3 and mGluR2 that and neurons, CRF of in the regulation of inhibitory transmission.These results suggest that amygdala group II mGluRs can regulate synaptic transmission tivation of mGluR2 by LY487379 decreased EPSCs, but not IPSCs, in the pain model, suggesting a critical involvement of mGluR3 by LY379268 resulted in a reduction of the synaptic responses (EPSCs and IPSCs) evoked by PB stimulation, whereas selective ac- inputs. PB of mGluRs stimulation II by group evoked of (IPSCs) Activation currents postsynaptic inhibitory glutamate-driven and (EPSCs) currents postsynaptic excitatory monosynaptic measure to used were neurons CRF of recordings patch-clamp Whole-cell rats (5-6h postinduction of a monoarthritis). In order to visualize CRF-CeA neuron in brain slices, we used transgenic Crh-Cre rats. (PAM)modulator (LY487379allosteric arthritic mGluR2 tive and for CRF-CeAnormal selective on from hydrochloride) neurons model. pain (LY379268 posi- agonist a mGluR and arthritic II salt) group disodium a of an effects the determine to performed in was physiology slice Brain question this address we study this In determined. be to remains neurons CRF-CeA on subtypes and mGluRs II group of modulation the plasticity, of synaptic effects regulate but and release neurotransmitter decrease can activation Their amygdala. the including regions, brain different in expressed are subtypes) (mGluR2/3 receptors glutamate metabotropic II group Gi/o-coupled pain. and behaviors of modulation the in involved regions CRF-CeAbrain other to project neurons containing nal lateral parabrachial nucleus (PB). The CeA is also the main source for extra-hypothalamic corticotropin releasing factor (CRF). The central nucleus of amygdala (CeA) serves major amygdala output functions, and receives nociceptive information via the exter and Therapeutics, Texas Tech University HealthSciencesCenter, Lubbock, TX tute on Aging, Texas Tech University Health Sciences Center, Lubbock, TX; 3 Center of Excellence for Translational Neuroscience Neuroscience, Texasand Pharmacology of Insti - Department TechGarrison 1 Center,2 Sciences Lubbock, TX; Health University M. Mazzitelli1,and V. Neugebauer1,2,3 arthritic pain Group IImetabotropic glutamate receptors regulate synaptic transmission ofamygdalaCRF containing neurons inamodelof GS3+ MAZZITELLI,MARIACRISTINA - - - 37 ABSTRACTS - - . Diego A Pedroza, Venkatesh Rajamanickam, Ramadevi Subramani, Alejandra Bencomo, Adriana Galvez, Alejandra Rajamanickam, Rajkumar Bencomo, Ramadevi Lakshmanas Subramani, Venkatesh Pedroza, A Diego Progesterone Receptor Membrane Component 1 communicates with classical steroid hormone signaling to promote breast cancer breast hormone signaling to promote steroid Receptor Membrane Component 1 communicates with classical Progesterone growth GS3+ PEDROZA, DIEGO GS3+ PEDROZA, Conclusion: Our data demonstrates that PGRMC1 plays a prominent role in regulating breast cancer growth and progression by pathway altering the PI3K/AKT/EGFR mechanisms and interacts with the classical signaling Results: Increased PGRMC1 and mRNA protein levels were observed in ER-positive ZR-75-1 cells, these results were validated and compared to online RNA-seq based gene expression analysis of breast cell lines and breast tumor data sets. Treatment of E2 and P4 increased cell proliferation while tamoxifen, RU-486, and silencing ER, PR and Phospho-proteome analysis PGRMC1 demonstrated decreased overall cell downregulation proliferation. of the PI3K/AKT and EGFR signaling mechanisms following AG-205 and PGRMC1 silencing. silencing Interestingly, ER, PR, and PGRMC1 demonstrates the communications between clas- sical and non-classical mechanisms. Materials and Methods: A panel of non-malignant breast and breast cancer cell lines were expression and cultured treated with E2, and (anti-estrogen), P4, Tamoxifen RU-486 AG-205 (anti-progestin), screened (PGRMC1 also antagonist). We for PGRMC1 silenced ER, western PR, blot, and and phospho-explorer PGRMC1 luciferase antibody using re- array, siRNAs. MTS, qRT-PCR, porter assay were performed. School: Graduate School of Biomedical Sciences School: Graduate School of Biomedical Introduction: Increased expression of the progesterone – receptor membrane component 1 (PGRMC1), a heme – binding protein with the ability to interact and stabilize epidermal growth factor receptor (EGFR), is frequently found in breast cancer Al- tissue. though progesterone (P4) and estradiol (E2) have been shown to stimulate and regulate cancer proliferation via the progesterone receptor (PR) and estrogen receptor (ER), the basis of the signaling mechanisms and communication can- breast alter can that mechanisms between signaling endocrine non–classical and classical identify to PR/ER/PGRMC1 aim We unknown. largely remains cer cell proliferation. meabilized bacterial membranes. Many functional host defense amyloids (i.e. biofilms, nanonets) contain a matrix made of amyloid of made matrix a contain nanonets) biofilms, (i.e. amyloids defense host functional Many membranes. bacterial meabilized and extracellular (eDNA). DNA Using DAPI (DNA) and thioflavin S (amyloid), we observed in eDNA the amyloid matrix from Taken infrastructure. its for important is DNA suggesting dispersed matrix the I, DNase with treated when Further, epididymis. the studies suggest that the epididymal amyloid matrix is a novel host defense structure. these together, wamy School: Graduate School of Biomedical Sciences The epididymis plays a critical role in protecting sperm from invading pathogens that can ascend the male tract. Due to the blood- proteins on the antimicrobial must rely heavily immune system and adaptive has a limited the epididymis barrier, epididymal (AMPs) of AMPs the innate immune system. AMPs It function. is In not some other yet organs, known mechanistically how these require an amyloid (cross-β-sheet) conformation for function, such as α-defensin 6 in the Aβ gut in and the brain whose amyloids form nets to trap pathogens. previously We established a nonpathological, functional amyloid matrix is in the epididymal lumen and contains the amyloid forms of the CRES subgroup (CRES, CRES2, CRES3, cystatin E2), a reproductive subgroup within the family 2 cystatins hypothesize of the cysteine epididymal protease amyloid We inhibitors. matrix is a novel host defense structure our hypothesis, we incu- test To pathogens. kill trap and can net around sperm that a protective form to create uses its amyloid that E. uropathogenic and coli E. type wild with hours two for amyloid CRES of states maturational various and monomer CRES bated coli and S. aureus strains in a colony forming unit These (CFU) results assay. showed the most pronounced antimicrobial activity was associated with CRES amyloid instead of its monomeric form. The endogenous amyloid matrix also caused a decrease in the survival of E. examine coli. To the antimicrobial mechanism, we performed a Live/Dead assay and observed CRES amyloid per Caitlyn Myers and Gail Cornwall Caitlyn Myers GS3+ MYERS, CAITLYN MYERS, GS3+ Defense Structure is a Novel Host Amyloid Matrix The Epididymal

ABSTRACTS 38 School: GraduateSchoolofBiomedical Sciences tial factorintheetiologyofHH-associated arthritis. expression. As a result, intestinal excretion of UA via ABCG2 is decreased, causing serum and tissue accumulation of UA, in ABCG2 a poten- decrease consequent with degradation p53 promoting accumulation, heme to leads HH in overload iron that conclude Wedegradation. proteasomal to subject is complex p53-heme and protein heme-binding a is p53 tract. intestinal mouse Hfe^-/- in reduced markedly was protein promoter. p53 this to binds p53 that immunoprecipitation chromatin with confirmed and promoter hABCG2 in elements Weand p53-responsive ABCG2. iron found between connection potential the examined we hyperuricemia, in UAcause mutations of ABCG2 and excretion intestinal mice. for Hfe^-/- responsible in As in is decrease Abcg2 ABCG2 a and (ABCC4) Mrp4 in increase an was however,there change; not did expression Glut9 UAabsorption/excretion. in involved porters mice. WeHfe^-/- in trans- higher various was examined activity enzymatic then the mice, Hfe^-/- and type wild between intestine in intestine and serum in UA of levels elevated and liver in different not was UA, generates controls. which to oxidase, compared xanthine mice of Hfe^-/- expression the Though detected We arthritis. HH-associated in role any uric plays of homeostasis disruption whether (UA) mice, acid Hfe^-/- using examined, we Here symptoms. these of etiology the in suspected is damage tive oxida- -induced Fe^2+ arthritis. and diabetes, cirrhosis/cancer,cardiomegaly,dysfunction, liver kidney in resulting overload, iron with associated is disease The HFE. gene iron-regulatory the in mutations by caused mostly is (HH) hemochromatosis Hereditary Bojana RISTIC,SathishSIVAPRAKASAM, and Vadivel GANAPATHY Hereditary hemochromatosis disruptsuricacidhomeostasisandcauseshyperuricemiaviairon/heme-p53-ABCG2 axis GS3+ RISTIC, BOJANA School: GraduateSchoolofBiomedicalSciences antibiotics haveapotentialtocombatbiofilminfections. alginate lyase+ levofloxacin and amylase+ tetracycline have exhibited the highest efficacy. far, Thus present. In conclusion, GHs biofilm in combination with of amount the determine to violet crystal with stained were biofilms combinations the treatment, GH+antibiotic Following 2hrs. various for with treated then were biofilms The establish. to biofilms allow to 24hrs for plates biofilm the antibiotics. Amylase and Pectinase decreased gentamicin sulfate efficacy. Next, SA31 or PAO1 was grown in 96-well MBEC® inactivating were GHs if determine to 24hrs for GHs+antibiotics or antibiotics, GHs, to exposed and plates 96-well in grown was (from xylanase and sp.), Rhizopus PAO1or SA31 2hrs. for antibiotics without or with either bacteria treat to used were oryzae) A. (from pectinase (from niger), amyloglucosidase algae), A. various (from lyase alginate (from oryzae), amylase A. GHs- following selected for further screening in addition with GHs that exhibited the highest dispersal efficacy in previous studies. 125 U/mL of the for (MICs) concentrations inhibitory 300µg/mL(PAO1)than aeruginosa lower Pseudomonas MIC were an had minimum that (SA31). antibiotics aureus The Staphylococcus and their determine to screened were classes various from antibiotics 16 infections. biofilm-associated clear to antibiotics and GHs of combination efficacious most the determining on focused study This microbes. dispersed to access agents antimicrobial allowing and cells, bacterial the dispersing EPS, the within found linkages glyosidic the for antimicrobial agents to reach the infection. Previously we have shown that glycoside hydrolases (GHs) are effective in breaking achallenge creates also but biofilm, the enter to cells immune for difficult it makes only not EPS (EPS). substance polymeric lular 85% of all bacterial infections are biofilm-associated. Biofilms are communities of microorganisms with a self-synthesized extracel USA Excellence; Research Texasof Center Burn the Surgeryand of Department TechCenter,Sciences Health University Lubbock, TX Whitni K.Redman&KendraP. Rumbaugh,Ph.D. The UtilizationofGlycosideHydrolase Alone orinConjunctionWith Antibiotics toClearBiofilm-AssociatedInfections GS3+ REDMAN, WHITNI - 39 ABSTRACTS School: Graduate School of Biomedical Sciences Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer. Our lab currently researches PepT1 (SLC15A1), a proton-coupled oligopeptide transporter that transports a wide array of di- and tri-peptides, as well as peptidomimetic drugs. Our preliminary data shows PepT1 to be upregulated in PDAC. The purpose of this study is to investigate the tumor promoting role of PepT1 and also to understand the mechanism of upregulation. achieve To this, PepT1 was knocked-out using a AsPC-1 shRNA. was used as the model cell line to generate AsPC-1-Ctrl and knockdown cell lines. After confirming PepT1 knockdown using 3H-GlySar uptake and subcutaneous xenograft were as conducted a migration to and measure invasion of assay, its function, colony formation assay, migration ability, formation colony the reduced PepT1 of absence the that note to interesting was It role. promoting tumor its study The to the control cells, suggesting its tumor promoting role. compared and reduced the tumor volume and the invasion capacity, mechanism of PepT1 literature upregulation evidences in have PDAC shown remains amino unknown. acids, Interestingly, dipep- tides, hormones, certain pharmacological agents, to binds and Sp1 wherein translocation transcription nuclear its factors to leading like Cdx2, and Sp1 Sp1 to and bind TME Cdx2 the in to available dipeptides regulate the that PepT1 hypothesize expression. We MMPs upregulates lactate that shows data preliminary Our expression. its regulates and promoter PepT1 the of region GC-rich the expression PepT1 upregulate dipeptides that show studies re-stimulation and deprivation acid amino Also, expression. DPP1V and in upregulated is PepT1 summary, In mechanisms. the into deeper probe to analysis ChIP perform to plan we Further, function. and PDAC and promotes its growth but the molecular mechanisms needs further elucidation. Bradley K. Schniers, Yangzom D. Bhutia Yangzom Bradley K. Schniers, GS3+ SCHNIERS, BRADLEY GS3+ SCHNIERS, to its substrates in response and is upregulated cancer growth PepT1 modulates pancreatic School: Texas Tech University Tech Texas School: Internal tandem duplications of domains in mosaic proteins can produce rapid expansion of protein domain repeats that serve as a protein mosaic the encodes Zan gene speciation Eutherian The species. of divergence adaptive for material genetic novel of source zonadhesin that mediates species-specific gameteTandem recognition. duplication of a Zan two-exon cassette has produced dra- matic D3p domain expansions in the Myomorpha Suborder of Rodentia, with varying numbers of repeats among species. Here we characterized the relationship between myomorph phylogeny and the pattern of D3p expansion. in Variation the number of D3p domains generally reflected species richness of taxa in the more terminal branches of rodent Comparative phylogeny. analyses of 21 domain Groups and three additional novel domain Groups specific to murid species identified primitive tandem repeats based on their statistically supported association to each other and their presence in all but one of the myomorph species examined. The progressively with expansion, the of end 5’ the on occurring are events duplication that indicates Groups domain the of architecture at diverge not did Groups primitive most The C-terminus. protein’s the to proximity in downstream pushed domains primitive more posi- of intensity greatest the exhibited phylogeny the in nodes among support least the with Groups and phylogeny, the of base the tive selection, suggesting an effect of differential positive selection on the evolution and functions of the corresponding domains. the 2) rodents; myomorph of divergence the since occurred events duplication domain D3p tandem of series a 1) that: conclude We duplication pattern reveals evidence of concerted gene evolution and pervasive and often intense positive selection within Groups; placement for and Myomorpha in species of inclusion for both criterion useful a be may expansion domain D3p of extent the 3) and of them within the various myomorph genera. 1Department 1Department of University; Biological Tech 2Natural Sciences, Texas Science Uni- Research Museum Tech Laboratory, at Texas Center Health Sciences University Tech Texas Biomedical Sciences, School of versity; 3Graduate Emma K. Roberts1, Emily A. Wright1, Robert D. Bradley1,2, and Daniel M. Hardy3 Bradley1,2, and Daniel Robert D. Wright1, A. Roberts1, Emily Emma K. GS3+ ROBERTS, EMMA ROBERTS, GS3+ rodents gene in myomorph evolution of a speciation unique reflect and divergence domain duplication Zan VWD

ABSTRACTS 40 School: GraduateSchoolofBiomedicalSciences treatment ofcoloncancer. target drug for promising a as SLC6A14 identify involves signaling. findings cancer Wnt These in upregulation its that and cancer confirmed by chromatin immunoprecipitation. These studies demonstrate that SLC6A14 plays a critical role in promotion of colon I-catenin whereas Wnt agonist or overexpression of I-catenin shows the opposite effect. Finally, SLC6A14 as a target for I-catenin is genetically driven colon cancer). In colon cancer cells, expression of the transporter is reduced by Wnt antagonist or by silencing of and cancer colon (inflammation-associated models experimental different two in cancer colon against protects mice in Slc6a14 of mouse tumor models, silencing of SLC6A14 by shRNA or blocking its function by α-MT reduces tumor growth. Similarly, deletion decreases mTOR deprivation, activity,acid increases amino autophagy,induces promotes SLC6A14, apoptosis, and of suppresses cell blocker proliferation and a invasion. In (α-MT), xenograft and α-methyltryptophan syngeneic with cells cancer colon of ment available publicly xenografts. by patient-derived supported are TCGAfindings These Genome Cancer (The database. Atlas) Treat least partly, Wnt signaling. Upregulation of the transporter is evident in most human colon cancer cell lines and also in a majority of in the upregulation remain unknown. Here we show that SLC6A14 is essential for colon cancer and that its upregulation involves, at but is upregulated in colon cancer. However, the relevance of this upregulation to cancer progression and the mechanisms involved colon normal in levels basal at expressed is It acids. amino cationic and neutral for transporter -coupled Na^+/Cl^− a is SLC6A14 Mohd OmarFarukSikder, SatishSivaprakasam, Vadivel Ganapathy SLC6A14, aNa^+/Cl^--coupledaminoacidtransporter, functionsasatumor promoter incolonandisatarget forWntsignaling GS3+ SIKDER,MOHDOMARFARUK School: GraduateSchoolofBiomedicalSciences layer ofregulationDVL-1proteins. a novel as acetylation uncover time, first the cancer. for Collectively,in findings implicated these genes of regulation and binding promoter its influences and DVL-1, of localization cytoplasmic over nuclear promote K285, and K69 residues, lysine key two of acetylation that identify localization. also cellular We activity, and protein influence to documented well are cancer.PTMs breast sine residues that show differential acetylation in response to changes in oxygen tension and deacetylase inhibition in triple-negative ly- DVL-1 12 report we Herein, analysis. mass-spectrometry chromatography liquid using sites acetylation novel for screened we 1 mediated deacetylation. To further examine the potential role of multiple families of lysine deacetylases in the regulation of DVL, lysine that demonstrated previously we deacetylase, SIRT-1,Since regulates tumorigenesis. DVL protein levels in and its function, we involved reasoned that DVL proteins could potentially be a substrate non-histone for SIRT-several of function the regulates yet little is known about their post-translational regulation. Acetylation is a reversible post-translational modification (PTM) which processes, cellular several of regulators versatile are and pathway signaling Wnt the of mediators central are proteins Dishevelled regulatory switch that controls DVL functions. These findings could help identify new therapeutic vulnerabilities in cancer biology. years. 60 past Wethe of for regulators signaling cytoplasmic Wnt as ied elegant and simple novel, a uncovered have to excited are lysine acetylation. This discovery has helped to redefine how we view DVL proteins since they have been almost exclusively stud- Scientific in published recently post-translational by controlled research is exit and PhD entry nuclear (DVL) Dishevelled my that report to first from the is study This findings (Nature). Reports novel present to like would I TTUHSC, at SRW 32nd the For Monica Sharma,DeborahMolehin,IsabelCastroPiedras,andKevinPruitt cancer Acetylation of conserved DVL-1 lysines regulates its nuclear translocation and binding to gene promoters in triple-negative breast GS3+ SHARMA,MONICA - 41 ABSTRACTS . - - - - The misfolding of prion protein gene (PRNP) products causes fatal neurodegenerative diseases called spongiform encephalopathies. spongiform called diseases neurodegenerative fatal causes products (PRNP) gene protein prion of misfolding The prion Various amino acid polymorphisms have been associated with three categories of spongiform encephalopathy: 1) familial, where disease alleles are inherited, 2) sporadic, in and which 3) mutations transmissible, arise where spontaneously, the prion dis- ease is infectious The among transmissible mammalian diseases organisms. can cross species barriers through consumption of af- human of cases first the to led that 1990’s the during encephalopathy spongiform bovine of outbreak the in occurred as tissue, fected variant Creutzfeldt-Jakob Disease. In wild and captive cervids (deer species), prion misfolding causes manage wildlife and an health, human biological, increasingly global raising is that prevalent (CWD), disease Wasting Chronic encephalopathy, spongiform University Tech Texas School: sity; 3Natural Science Research Laboratory at the Museum of Texas Tech University; 4Department of Cell Biology & Biochemistry, Biochemistry, & Biology Cell of 4Department University; Tech Texas of Museum the at Laboratory Research Science 3Natural sity; University Health Sciences Center Tech Texas a poses consumption and handling that possible remains it documented, been not has humans to transmission While concerns. ment co- known Several symptomatic. clinically be not may cervids infected harvested, that considering especially health, human to risk resistance. confer can that others and disease in result spontaneously that some misfolding, prion to susceptibility affect variants don and cervids among sequences 3 exon characterizing currently are we so region, coding protein entire the encompasses 3 exon PRNP disease to susceptibility affect may that variants codon potential identify to populations, domestic and wild both in mammals, other and likelihood of transmission across species barriers. These analyses of PRNP sequences will provide insight into functionally prevention of potential transmission to humans. allelic variation relevant to disease management in cervids and important PRNP 1Department of Biological Sciences, Texas Tech University; 2Department of Natural Resources Management, Texas Tech Univer Tech University; 2Department of Texas Natural Resources Management, Tech 1Department of Texas Biological Sciences, Emily A. Wright1, Matthew A. J. Wright1, A. Grisham2, Buchholz2, Robert Blake D. Emily Bradley1,3, Daniel M. Hardy4, Emma K. Roberts1, and C. Conway2 Warren Allelic variation in PRNP exon 3, susceptibility to neurodegenerative prion disease, and implications for inter-species transmission inter-species for and implications prion disease, neurodegenerative to 3, susceptibility exon PRNP in variation Allelic GS3+ WRIGHT, EMILY GS3+ WRIGHT, bers may interact with αβ dimers, which in turn may form by association of distinct αxβy combinations (α1-α4, β1-β3). Isoform expression presents with tissue-, cell- Each and FXYDsubcellular isoformspecificity. alters the apparent affinities for transported and hippocampus mouse in microscopy immunofluorescence confocal and co-immunoprecipitation used We isoforms. α1β1 of ions cerebellum, as well as in human neuroblastoma SH-SY5Y cells, to determine the interaction and localization of the brain-specific FXYD6. FXYD6 polyclonal antibodies prominently stained the Purkinje cells (bodies and dendrites) and the molecular layers of the cerebellar cortex, as well as the CA1 pyramidal and the dentate gyrus of the hippocampus.The strongest FXYD6 staining ap- pears to be perinuclear and intracellular. performed We co-immunoprecipitation followed by analysis Western-blot to determine pulled FXYD6 cells SH-SY5Y and cerebellum hippocampus, in that found and partners interacting α specific has FXYD6 whether down both α1 and α3 (reciprocally α1 and α3 pulled FXYD6 The down). kinetic effects of FXYD6 associationwith α1β1 or α3β1 electrophysiology. clamp patch and clamp voltage two-electrode the utilizing isoforms, these expressing oocytes in evaluated were FXYD6 produced several effects: 1) Significantly reduced (2-4-fold) the number of a1β1 and α3β1 at the membrane surface lead α1β1. of rate turnover the increased 4) and (~2-fold) α1β1 in affinity Na+I apparent the reduced 2) current, NKA diminished to ing more accuracy cellular localization, protein interactions, and physiologic function with Current experiments aim to refine FXYD6 Sciences School: Graduate School of Biomedical - neces gradients K+ and Na+ the generates it where cells animal all of membranes the in ubiquitous is (NKA) Na+,K+-ATPase The It consists of sary one for α cell and excitability. one β subunit, and often, a FXYD regulatory subunit. Seven FXYD family mem Ryan Sweazey and Pablo Artigas Sweazey and Pablo Ryan GS3+ SWEAZEY, RYAN SWEAZEY, GS3+ ATPase with the Na+,K+ in the CNS and interaction Localization FXYD6: membrane protein The regulatory

ABSTRACTS 42 School: Graduate SchoolofBiomedicalSciences ing noveltargets foracentralprocessofpathological conditions,suchas tumorangiogenesis,metastasis andinflammation. tion/polymerization and leading to cell migration. This study reveals a novel pathway of Ang2-induced HDLEC migration, provid - In conclusion, Ang2 induces HDLEC migration through integrin-mediated RhoA and FHOD1 activation, inducing actin filamenta and preliminaryexperiments in thesamemodelshowthatendothelialRhoA migration. cell Ang2-induced assay,sponge ear the using experiments vivo in by supported was lymphangiogenesis Ang2-induced bition reduced cell migration even in the presence of Ang2. Knockdown experiments highlighted that FHOD1 was responsible for downstream RhoA effector. Formins are actin-nucleators and are downstream targets of integrin and RhoA activation. Formin inhi- a ROCK, of inhibition upon blocked not FAKwas not migration but and phosphorylation. cell pMLC, Akt Ang2-induced and Src induced stimulation however,Ang2 migration, cell for necessary where Src FAKand Both binding. PDZ-RhoGEF and GEF-H1 upon occurred which activation, its for integrin beta-1 required and migration, cell Ang2-induced for pivotal was RhoAmanner. Ang2 induced Human Dermal Lymphatic Endothelial Cell (HDLEC) migration and activated RhoA in a time- and dose-dependent ment. Here,weinvestigated Ang2-driven effectandsignalingpathwaysinlymphangiogenesisvitro in vivo. treat and diagnosis recognition, accurate their in helps diseases these of processes molecular the Understanding metastasis. and injury, growth lung tumor acute promotes sepsis, it as where such tumors, conditions, and inflammatory pneumonia, in present are Elevated adulthood. in uterus and placenta ovaries, as such remodeling, vascular active of levels regions Ang2 in expressed highly is pathway.Ang2 signaling Angiopoietin/Tiethe of agonist/antagonist context-dependent a considered is (Ang2) Angiopoietin-2 partment ofObstetricsandGynecology, SchoolofMedicine, Texas Tech UniversityHealthSciencesCenter, Amarilllo, TX De- Center,TX; Amarillo, Sciences Pharmacy,Health Texasof Tech University School Sciences, Pharmaceutical of Department Akwii R.G.,1ZahraF.T.,1 SajibM.S.,1 Tullar P.,2 MikelisC.M.1 Formins: Mediatorsof Angiopoietin 2-induced,Tie2-independent lymphaticendothelialcellmigration PHAR AKWII,GRACE RACHEAL School: GraduateSchoolofBiomedicalSciences Current experimentsaimtorefineFXYD6cellularlocalization,proteininteractions,andphysiologicfunctionwith more accuracy ing to diminished NKA current, 2) reduced the apparent Na+I affinity in α1β1 (~2-fold) and 4) increased the turnover rate of α1β1. lead surface membrane the at α3β1 and a1β1 of number the (2-4-fold) reduced Significantly 1) effects: several produced FXYD6 were evaluated in oocytes expressing these isoforms, utilizing the two-electrode voltage clamp and patch clamp electrophysiology. α3β1 or α1β1 with association FXYD6 of effects kinetic down). The FXYD6 pulled α3 and α1 (reciprocally α3 and α1 both down whether FXYD6 has specific α interacting partners and found that in hippocampus, cerebellum and SH-SY5Y cells FXYD6 pulled determine to Western-blotanalysis by followed co-immunoprecipitation Weperformed intracellular. and perinuclear be to pears ap- staining FXYD6 strongest hippocampus.The the of gyrus dentate the and pyramidal CA1 the as well as cortex, cerebellar the of layers molecular the and dendrites) and (bodies cells Purkinje the stained prominently antibodies polyclonal FXYD6 FXYD6. brain-specific the of localization and interaction the determine to cells, SH-SY5Yneuroblastoma human in as well as cerebellum, ions of α1β1 isoforms. We used co-immunoprecipitation and confocal immunofluorescence microscopy in mouse hippocampus and transported for affinities apparent the alters specificity. isoform subcellular FXYD and Each cell- tissue-, with presents expression Isoform β1-β3). (α1-α4, combinations αxβy distinct of association by form may turn in which dimers, αβ with interact may bers mem family FXYD Seven subunit. regulatory FXYD a often, and subunit, β one excitability.and cell α for one sary of consists It The Na+,K+-ATPase (NKA) is ubiquitous in the membranes of all animal cells where it generates the Na+ and K+ gradients neces- Ryan SweazeyandPablo Artigas The conformationaldanceoftheNa+-pumpstudiedwithVoltage ClampFluorometry GS3+ YOUNG, VICTORIA PHARMACEUTICAL SCIENCES|SCHOOLOFPHARMACY isimportantfor Ang2-induced lymphangiogenesis. - - - - . 43 ABSTRACTS - infected individuals who smoke. School: School of Pharmacy lium dysfunction thereby worsening cerebrovascular condition. CONCLUSIONS - Co-exposure to tobacco smoke extract (TSE) gp120 and (gp120) HIV-1 further aggravated the BBB endothe BACKGROUND - The rate of tobacco smoking is exceedingly high in HIV infected individuals (40-65%) when compared with the with compared when (40-65%) individuals infected HIV in high exceedingly is smoking tobacco of rate The - BACKGROUND general population (15%). Furthermore, 50% of the HIV infected population exhibits neurological complications, including Neu- peripheral and central the to damage HIV-mediated by primarily caused disorders neurological of group a identifies which roAIDS, The oxidative damage and nervous inflammatorysystems. stress caused by chronic smoking on the cerebrovascular system is well that agent stress-inducing inflammatory and oxidative potent a is smoke tobacco that demonstrated have we lab, our In established. can facilitate the loss of BBB function and mitochondrial redox balance leading to a host of comorbidities. The envelope HIV-1 glycoprotein (gp120) is neurotoxic and is known to cause oxidative stress with direct implications for blood-brain barrier (BBB) impairment. However, whether a synergism exists between the two in the context of HIV infection in the CNS is not known. We effect contributory a have may gp120 protein envelope HIV-1 and smoking tobacco by caused stress oxidative the that hypothesize on the increasing burden of NeuroAIDS related morbidity and mortality in HIV dys- endothelium BBB the aggravated further (gp120) gp120 HIV-1 and (TSE) extract smoke tobacco to Co-exposure - RESULTS We expression. protein TJ permeability, (TEER), Resistance Electrical Trans-Endothelial measuring by this evaluated We function. expression and mitochondrial function. also evaluated antioxidant defense (NRF2) , inflammatory response (NFκB) Aditya Bhalerao, Dr. Luca Cucullo Aditya Bhalerao, Dr. METHODS cultured - We Primary Human Brain Microvascular Endothelial Cells (HBMECs) and treated confluent monolayers Smoke Extract (TSE) and gp120 in individual and combination treatments for 24 h Tobacco with HIV infection in the CNS – How smoking can lead to adverse outcomes infection in the CNS – How smoking can lead HIV PHAR BHALERAO, ADITYA PHAR BHALERAO, School: Graduate School of Biomedical Sciences School: Graduate School of Biomedical Inflammatory bowel disease (IBD) is a debilitating chronic inflammatory disease affecting the small and large intestine. IBD can be can IBD intestine. large and small the affecting disease inflammatory chronic debilitating a is (IBD) disease bowel Inflammatory had population US the of 1.3% about adults, million 3 2015, In Colitis. Ulcerative and Disease Crohn’s into subcategorized further been diagnosed with IBD. There are significant problems when it comes to this disease.dis- the Itsof management etiologytemporary on is focus available poorlytreatments IBD; understood,for cure which no currently is There challenges. therapeutic to leads mes- Recently, microbiome. the of dysbiosis and barrier intestinal weakened a inflammation, chronic by characterized is IBD ease. affects, immunomodulatory have cells stem Mesenchymal IBD. for therapy potential a as attention gained have cells stem enchymal can that cell stem mesenchymal of subtype a are cells stem pulp-derived Dental potential. healing wound and properties, angiogenic from obtained be can they because cells stem mesenchymal for source attractive an are They teeth. wisdom human from extracted be cells stem pulp-derived dental of use potential validate to undertaken was study current Our byproduct. medical a as surgery routine a experiencing constantly is IBD As herewith. mechanisms defining and models animal different two using IBD of treatment the for their on impact any has signals proinflammatory with DPSC priming whether investigate to plan we environment, proinflammatory LPS, as such reagents bioactive the with DPSCs primed that show we vitro, in validation our of step first In function. and behavior TNF-α, or IFN-γ, alter their immunologic properties by IDO expressing and higher Il-4. levels In of addition, IL-10, primed HGF, DPSCs also altered monocyte polarization towards immuno-suppressor phenotype (M2), where monocytes expressed higher lev- els of IL-4R, IL-6, and Ym1 upon co-culture with primed DPSC. Moreover, primed DPSCs induced accelerated wound healing determined by using healing a of gut gut epithelial epithelial cell Wound cells scratch was wound mediated assay. by inactivating data these Collectively DPSCs. primed the with co-cultured when pathways ERK1/2 and STAT3 NF-κB, AKT, active constitutively provide evidence that DPSCs have potential to reduce inflammation, M2 polarization of myeloid cells, and heling and constitutively active signaling pathways. epithelial cells through inactivation of inflammation damaged gut Sarah Anderson and Hiranmoy Das Anderson and Hiranmoy Sarah PHAR ANDERSON, SARAH ANDERSON, PHAR Bowel Disease with Inflammatory wound healing associated and accelerate inflammation reduce stem cells Dental pulp-derived

ABSTRACTS 44 School: SchoolofPharmacy Shh signaling. and 90% respectively. Conclusively, our results indicate that moxidectin effectively reduces the growth of MB tumors by inhibiting results Our demonstrated that mice. 5mg/kg the and of 10 flank mg/kg moxidectin left by and oral right administration the everyday suppressed in the cells growth MB of Daoy Daoy tumors human by injecting 70% subcutaneously by model tumor vivo in an in evaluated was of moxidectin Efficacy Nanog. and Sox-2 Oct-4, Pax-6, as such molecules effector downstream their and Gli1 and caspase 3 and PARP. Western blotting analysis demonstrated that moxidectin treatment significantly reduced the expression of Shh by evaluated AnnexinV-FITC/PIas lines cell of MB assay,cleavage the increased all and in apoptosis fold 3-4 induce to able was cells. The IC50 of moxidectin in all the MB cell lines ranged 10-17μM after 24, 48 and MB 72 of hours proliferation of reduced treatment. significantly in Moreover,resulted treatment moxidectin moxidectin that demonstrated results manner.Our dependent time and concentration a in moxidectin with treated were PFSK1 and ONS76, UW228, Daoy,UW426, as such lines cell MB Several moxidectin. of effects anti-cancer the evaluated study,have current we pathway.the signaling In this of factor transcription major a Gli1, of activation amplified with along SuFu and SMO PTCH1, in mutations by characterized is Shh-MB nature. in metastatic and aggressive highly be to considered is MB of subgroup activated (Shh) hedgehog Sonic patients. these of mortality and bidity mor the on impact profound a has It children. in tumors brain common and malignant most the of one is (MB) Medulloblastoma Itishree KaushikandSanjaykSrivastava Moxidectin, anoveltherapeuticcandidateforpediatricmedulloblastoma PHAR KAUSHIK, ITISHREE School: GraduateSchoolofBiomedicalSciences surgical prophylaxis underanesthesia. in used currently is which gentamicin, as such drugs, neurotoxic with seen are effects similar whether determine to needed are ies Conclusion: The study provides evidence that isoflurane increases BBB permeability without tight junction disruption. Further stud- levels after24hours. basal to returned which (p<0.01), groups treatment and control between vivo in and vitro in both observed were permeability in systems and erythrocyte ghosts, anisotropy decreased in a dose dependent manner after isoflurane exposure. Significant differences cyte ghosts showed a significant decrease (p<0.05) in fluorescence intensity in the isoflurane treated group. In different liposomal Erythro- conditions. treatment between difference a show not did cells in proteins junction tight for Immunofluorescence Results: and fluoresceinasmarkersofpermeabilitywasdoneinanesthetizedmicecomparedagainsttheawakecondition. ments on erythrocyte ghosts and liposomes. In vivo measure- pharmacokinetic based study anisotropy to assess fluorescent brain through uptake assessed clearance, Kin, were of dynamics [13C12] membrane sucrose in Changes flowcytometry. by analyzed were cells. Fluorescein loaded erythrocyte ghosts were exposed to anesthetic agents and differences between control and treated samples endothelial brain derived iPSC on out carried were immunofluorescence and measurements studies, TEER Permeability Methods: vitro andinvivo. in exposure anesthesia upon BBB in changes assess to was work present the of goal role. The a play may membranes cell on fects in BBB permeability soon after anesthesia induction. Considering the rapid time course, we hypothesized that physicochemical ef- factor.causative increase the We 2-fold as a deemed found was exposure prolonged after proteins junction tight of disruption The Introduction: Multiple studies have recently reported the volatile anesthetic agent isoflurane damages the blood-brain barrier (BBB). Chowdhury Ekram Ahmed Isoflurane increases bloodbrainbarrierpermeabilitywithoutdisruptingtightjunctions PHAR CHOWDHURY, EKRAMAHMED - 45 ABSTRACTS - APP and APP To investigate the impact of To We have used an isogenic in vitro model of We . Alzheimer’s disease is characterized by the presence of senile plaques and neurofibrillary tangles. Earlier research targeted Aβ research targeted characterized by the presence of senile plaques and neurofibrillary tangles. Earlier disease is Alzheimer’s of several transgenic animal models overexpressing mutated forms of plaques formation, including the generation Snehal Raut; Abraham Al-Ahmad Abraham Snehal Raut; is to study the genetic mutation and abnormal AD. Our hypothesis in the treatment of PSEN1. It failed to yield notable advances aim to study the impact of PSEN We will provide better understanding of disease pathophysiology. AD peptides associated with cells. mutation on BBB function using iPSC derived brain microvascular endothelial and with mutations in PSEN1 or PSEN2 genes. PSEN1-BMECs the BBB based on patient iPSCs isolated diagnosed with FAD impaired barrier function compared to control displayed a lower expression of tight junction proteins. PSEN1-BMECs showed to controls and PSEN2-BMECs. PSEN1-BMECs iPSC lines. PSEN1-derived BMECs showed a lower glucose uptake compared inhibitor II. failed to show inhibition of glucose uptake following treatment with glucose transporter in iPSC-derived BMECs. PSEN1-BMECs such impaired glucose uptake on cell metabolism, we studied changes in glycolysis Results showed an impaired mitochondrial function showed a notable decrease in acidic lysosomes compared to control-BMECs. at the BBB using iPSC-derived BMECs. Aβ peptides on glucose metabolism of we evaluated the effect in PSEN-BMEC. Further, BBB following treat observed the presence of a dose-dependent decrease in GLUT1 expression and glucose diffusion at the We Assessing the impact of Alzheimer’s disease on the blood brain barrier in vitro using induced pluripotent stem cells (iPSCs) on the blood brain barrier in vitro disease Alzheimer’s Assessing the impact of PHAR RAUT, SNEHAL PHAR RAUT, School: School of Pharmacy School: School of Pharmacy Aβ 1-42 impacts glucose Aβ 1-40 vs are investigating how the different We Ab peptides in a dose-dependent manner. ment with in GLUT1 expression occurs. Our study metabolism at the BBB and identify by which signaling pathway such down-regulation PSEN mutations at the BBB, in particular between constitutes the first report of the presence of BMEC phenotype associated with PSEN1 and PSEN2 mutant carriers. Pancreatic Pancreatic cancer patients have limited treatment options in spite of several advanced treatment strategies. Pancreatic tumors ex- hibit high basal autophagy compared to other cancers. Several studies including from our lab reported that enhanced can autophagy lead to apoptosis in cancer cells. In this study, we have demonstrated that pimavanserin (PVT) suppresses pancreatic growth by induced inducing apoptosis autophagy and mediated reduced apoptosis. the Our proliferation results indicated that PVT tumor the inhibited PVT In addition, hours of treatment. 72 and 24, 48 3-9µM after between IC50 ranging with cells cancer of pancreatic in resulted PVT of concentrations increasing with cells cancer pancreatic of Treatment cells. cancer pancreatic of formation colony concentration induceddependent increase the PVT in expres- autophagy as evaluated by acridine orange assay by flow-cytometry. sion of autophagy markers ULK1, Atg101, FIP200, Beclin-1, LC3A/B in a concentration dependent manner in several pancreatic Oral PARP. of caspase3 and in cleavage by increase cancer cells was validated in pancreatic effects of PVT Apoptotic cancer cells. administration of PVT suppressed BxPC3 tumor xenografts by 50% in athymic nude mice. In another in vivo treatment Autophagy inhibited tumors and the by apoptosis growth 77%. was of experiment, confirmedorthotopicaly inimplanted the PANC1 PVT general exhibit not did PVT of administration Chronic blotting. western and immunohistochemistry by mice treated PVT of tumors chemistry clinical the altered not did PVT of administration long-term Moreover, mice. in effects side behavioral or toxicity of signs was suppression growth tumor pancreatic mediated PVT that indicate results our Collectively, albumin. AST, ALT, like parameters associated with induction of autophagy and apoptosis. Since, PVT is already available in clinic with an established safety profile, for pancreatic cancer therapy our results will accelerate its clinical development Sharavan Ramachandran and Sanjay K. Srivastava Ramachandran and Sharavan PHAR RAMACHANDRAN, SHARAVAN RAMACHANDRAN, PHAR drug Pimavanserin by a novel anti-Parkinson of autophagy induction through suppression growth tumor Pancreatic

ABSTRACTS 46 School: GraduateSchoolofBiomedical Sciences tivity relationship studies forthis classofcompoundsandproposedmechanisms of action associated with their anticancer activity. molecular targets for these compounds using standard immunoblotting techniques. Here, we report the current state of structure-ac identified we addition, In analogs. these of activity anticancer the for responsible features key the elucidate to compounds 40 than cross the blood-brain barrier in vitro and in vivo, and optimized toxicological profile. We synthesized and analyzed a library of more to ability lines, cell MCF-7 and MDA-MB-231 against cytotoxicity with agents Recently, anticancer of class novel a identified we same time, TNBC showsgoodresponsetochemotherapy, andsearchfornovel anticanceragentsisvital. of TNBC patients suffer from the brain metastases, leading to decreased survival rates compared to other breast cancer types. At the African-American and Hispanic descent. TNBC is characterized by higher metastatic and reoccurrence rates, as approximately 28% of primarily women, younger in common more is TNBC that suggest studies Epidemiological ineffective. treatment HER2-based and therapy hormonal renders it genes. Therefore, (HER2) 2 receptor factor growth epidermal human and (PR) receptor gesterone pro- (ER), receptor estrogen of expression the lacking type cancer breast aggressive an is (TNBC) cancer breast Triple-negative ences Center, Lubbock, TX TX Amarillo, Pharmacy, of for Excellence of Translational2^Center States; United 79106, and Neuroscience Therapeutics, Texas School Tech Center,Sci- Health University Sciences Health University TechTexas Sciences, Pharmaceutical of 1^Department Sadisna Shahi^1,Md Ashraf-Uz-Zaman^1, RachealG. Akwii^1, Constantinos M.Mikelis^1,Nadezhda A. German^1,2 Novel compoundsforthetreatment oftriple-negativebreast cancerwithoptimizedtoxicologicalprofile PHAR SHAHI,SADISNA School: GraduateSchoolofBiomedicalSciences the treatmentofPA-induced infections. antibiotics have inhibited the production of biofilm and pyocyanin at the levels of ¼ MIC, suggesting the preferential use of later in selected contrast, In ½ MIC). to (up levels MIC sub at effects pro-virulence strong the with agents antimicrobial several identified we have settings. aresult, in clinical As efficacy treatment and progression disease on effect pronounced a have to shown are both production; pyocyanin and formation biofilm included study our in assessed factors virulence The agents. antimicrobial these of concentration MIC sub the by induced activity bacterial the on strain the of type density, and cell media, of effect the levels, MIC PAO1sub strain), the (clinical PA14at and potentiation virulence strain), include (reference parameters analyzed (wild-type). The ciprofloxacin, gentamicin, tobramycin, amikacin, colistin, and aztreonam, against three different strains of P. aeruginosa: PG02354 among different antimicrobial agents was performed. In our study, we have evaluated selected antibiotics, meropenem, doripenem, potential virulence of cross-comparison no Further, agents. antimicrobial of levels MIC sub of activity virulence-inducing the on ria, a composition of a growth media, and cell density. However, no data were reported analyzing the effect of the same parameters Bactericidal/bacteriostatic activity of an antibiotic in vitro is shown to be affected by several parameters, including a strain of bacte regimen. bacterial resistance. Thus, a clear understanding of the mechanisms involved in these events is required to optimize the therapeutic ics at concentrations below the MIC levels (sub MIC) trigger the production of extracellular virulence factors, acting as inducers of pyocyanin, further reduces the effectiveness of antimicrobial therapy. Moreover, multiple reports have shown that selected antibiot tions. In addition to naturally occurring resistance of PA to many antibiotics, its ability to form virulence factors, such as biofilm and Pseudomonas aeruginosa (PA) is an opportunistic pathogenic bacterium capable of causing a wide array of acute and chronic infec Siavash ShahbaziNia,Mohammad Anwar Hossain,NadezhdaGerman Pro-virulence potencyofantimicrobial agentsinP. aeruginosa PHAR SHAHBAZI NIA,SIAVASH - - - - 47 ABSTRACTS - - - activation. Results: Pharmacological RhoA inhibition or RhoA knockdown abrogated bFGF-induced in vitro angiogenesis. In vivo, tamoxifen- vivo, In angiogenesis. vitro in bFGF-induced abrogated knockdown RhoA or inhibition RhoA Pharmacological Results: induced endothelial RhoA-deficiency blocked bFGF-induced angiogenesis. Mechanistically, bFGF activates RhoA, through the RhoA-specific GEFs, such as GEFH1, Among P115, LARG the and bFGF PDZRhoGEF. receptors, FGFR1 is predominantly ex- pressed in HUVECs and FGFR1 knockdown abrogated bFGF-induced activation RhoA and angiogenesis. Downstream, is RhoA Ongo- affected. not are activation p38 and ERK bFGF-induced however phosphorylation, JNK bFGF-induced in involved partially bFGF-induced RhoA ing experiments are aimed to delineate the downstream signaling pathway of School: Graduate School of Biomedical Sciences logical inhibition or knockdown of endothelial RhoA on bFGF-induced angiogenesis in human umbilical (HUVECs). vein Pull-down experiments and endothelial other biochemical assays cells were performed to identify the molecular mechanism of bFGF- induced RhoA activation. In vivo, endothelial-specific inducible RhoA-deficient mice with a fluorescent reporter were used in a modified matrigel plug angiogenesis model. pathway participates in bFGF-induced angiogenesis highlighting its role as a our data suggest that RhoA Conclusion: Collectively, therapy. for anti-angiogenic common target Methods: In vitro experiments (cell migration, 2D and 3D sprout formation) were performed to assess the impact of pharmaco Objective: Current antiangiogenic therapies target vascular endothelial growth factor pathways. However, development (VEGF) of resistance due or to bFGF the upregulation remains VEGF-induced a serious disadvantage signaling of current approaches, demanding efforts ofsimultaneous targeting of VEGF and FGF pathways.The small GTPase has RhoA been reported to regulate VEGF-induced angiogenesis. In the present study we investigate the role of endothelial RhoA in bFGF-induced angiogenesis to can be considered a common downstream target. identify whether RhoA Fatema Tuz Zahra, Md Sanaullah Sajib, Racheal G. Akwii, Paul Oikonomou, E. Vasileios Tullar, Mihalis S. Lionakis, Laurence Constantinos M. Mikelis Wood, Endothelial small GTPase RhoA regulates bFGF-induced angiogenesis: A potential target for anti-angiogenic therapy for potential target A angiogenesis: bFGF-induced regulates Endothelial small GTPase RhoA PHAR ZAHRA, FATEMA TUZ PHAR ZAHRA, FATEMA Traumatic Brain Injury (TBI) is one of the most common causes of cerebrovascular and neurological damage worldwide. It has been has It worldwide. damage neurological and cerebrovascular of causes common most the of one is (TBI) Injury Brain Traumatic health public main and habit addictive most the of one (TS, smoking tobacco as such conditions premorbid that suggested recently dissect and investigate to is study present the of aim The recovery. TBI post of retardation and TBI of exacerbation to leads hazards) out the pathophysiological TBI mechanisms (simulated underlying using the a exacerbation of head weight drop model) following weeks. three for TS to exposed chronically were weeks 6–8 range age mice, C57BL/6J male purpose, this For exposure. TS chronic animals were TBI then by subjected guided to vertical head weight drop using a 30 g Test metal weight free felling from an 80 cm distance before reaching the target. Physical activity and body weight of the mice were analyzed before TBI and 1 h, 24 h analy molecular and biochemical subsequent for samples and brain and blood collect to sacrificed were mice 3 Finally, post-injury. days Sciences School: Graduate School of Biomedical macology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia Saudi Riyadh 11451, King Saud University, of Pharmacy, College Toxicology, macology and blotting was sis. Western applied to assess the expression of Nrf2 as well as tight junction proteins associated with BBB integrity including, ZO-1, Occludin, Claudin-5 from brain tissues homogenates. Levels of NF-kB along with pro-inflammatory cytokines IL-6, on IL-10 TNF-α blood and The were samples. results measured revealed by TS that ELISA promoted significantly increased TS to exposed chronically mice Additionally, mice. test TS-Free to compared when TBI in integrity BBB of loss and inflammation prior to TBI experienced a more significant weight loss, behavioral, and motor activity deficiency and slower post-TBI recovery when compared to TS-free TBI mice. In conclusion, TS promotes a significant exacerbation of post-TBI neurovascular and neu- rological impairments. Whereas BBB impairment and pro-inflammatory vascular responses induced by chronic TS exposure are post-traumatic recovery observed in these animals likely responsible for the retardation of 1 Department of Pharmaceutical Sciences, Texas Tech TX University 79106, Health USA; Sciences 2 Center,Amarillo, Center Tech for 1 Department of Pharmaceutical Texas Sciences, Blood-Brain University Barrier Tech Health Research, Amarillo, Sciences Texas TX Center, 79106, USA; 3 Department of Phar Farzane Sivandzade1, Faleh Alqahtani 3, Ali Sifat1, Luca Cucullo1,2* Ali 3, Alqahtani Faleh Farzane Sivandzade1, PHAR SIVANDZADE, FARZANE SIVANDZADE, PHAR and Recovery Injury Outcome Brain on Post Traumatic Smoking of Chronic Impact and Neurological Cerebrovascular Assessing

ABSTRACTS 48 School: School ofMedicine study presents a potentiallysuccessfulsurgical approachtotreatingcongenital Kyphosisininfants. case This size. and patient’s age particular this given especially difficult quite be can deformity.correction this Surgical with ated associ- progression rapid the to surgicaldue and treatment diagnosis quick require Kyphosis Congenital with Patients Conclusion: TLSO brace.Post-opX-Rays weretakentwoweeksafterconfirmingcorrection. was placed on posterior elements after fusion appeared to be stable. Following procedure, patient was placed into custom clamshell targetof visualization initial for fusion. utilized posterior was of Fluoroscopy assessment wiring. and nar vertebrae bone Autograft deformity.correct sublami and bilateral progression with stop vertebrae L3 the to of T12 fusion posterior involved procedure The abnormalities. Films during follow up revealed progression of kyphosis to 50o. Surgical intervention was recommended in order to renal and cardiac out rule to studies ultrasound renal and echo as well as MRI and films repeat with months 3 in re-evaluation for the lumbar spine were consistent with Congenital Kyphosis with the apex at L2 and curvature of approximately 35o. Initial plan was region. lumbar the in of spine APviews the Lateral of Report: and curvature Case with clinic the Ato presented male old 6-month to neurologicalsymptomsincludingparaplegia. (Typevertebrae anterior the of (Typeboth of mixture a or II), lead and rapidly progress can Kyphosis Congenital untreated, If III). 30 – 60o. This deformity can be attributed to either a failure of formation of the anterior vertebrae (Typetypically I), failure of of segmentation spine the of curvature forward a with associated is that disorder uncommon an is Kyphosis Congenital Introduction: Cody BeaverMD,Jon Wall MD,Jonathan Abraham Posterior SpinalFusionwithInstrumentationandBone Autograft forType ICongenitalKyphosisina10-monthMale MS1-2 ABRAHAM,JONATHAN School: SchoolofMedicine Conclusion: Hemorrhagiccholecystitisisamedicalemergency withahighrateofmo October 17,2019. on discharged was patient the and uncomplicated, was course postoperative The Endoloop. 0-PDS a with controlled was it duct, because of extreme distention and blood clots were evacuated. Prolonged adhesiolysis was performed. Due to the size of the cystic The patient was taken to the OR within 18 hours of admission for laparoscopic cholecystectomy. The gallbladder was decompressed total bilirubinof0.9,andalipase16. 0.98, of INR 267, of count platelet 14.9, of hemoglobin 8, of WBC 2.4, of lactate serum initial an indicated labs and work Blood ER. the in instability hemodynamic without and afebrile was patient The hemorrhage. intraluminal or malignancy for suspicious neous attenuation within. This prompted the ultrasound which demonstrated heterogeneous infiltration within the gallbladder lumen emergency medicine physicianorderedastatCT scanaortadissectionprotocol. CTa distendedgallbladder showedwithheteroge the presentation, her of Because pain. back severe to due suddenly sleep from awoken was She position. decubitus lateral left in Results: Patient presented on October 14, 2019 to the ER with severe acute RUQ abdominal pain and thoracic back pain, improved well asoutpatientf/uatthesurgery clinic. review. Data and information were collected via chart review of EMR at UMC from the initial ER visit, the intrahospital course, as Methods: We present a case of a 48 year old female who underwent laparoscopic cholecystectomy in October of 2019 with literature renal failure.DiagnosishingesonahighindexofsuspicionwithconfirmatorystudiessuchasCT tified in the literature include history of trauma and anticoagulant use. It can also present in the settings of malignancy, cirrhosis, and Introduction: Hemorrhagic cholecystitis is a rare subtype of acute cholecystitis with an incidence of 3.5%. Specific risk factors iden- Dayton MD, Luong Linda Wong MD,StevenBrooksCatherineRonaghanFACMD, VincentAthas Freedle, Caroline Payberah, Ebrahim MS, Rahesh Jasmin MBA, Abidi Hussain Atraumatic SpontaneousHemorrhagic Cholecystitis;anatypicalpresentation ofarare case MS1-2 ABIDI,HUSSAIN MEDICAL STUDENTSYEARS1-2|GRADUATE MEDICALSCIENCES|PUBLICHEALTH scanorultrasound. - - 49 ABSTRACTS - A gap in knowl- A This study combines This study aims to test Ambulatory Medical Care Survey, a nationally Ambulatory Medical Care Survey, Homeless individuals frequently use the Emergency Department (ED). Previous studies have shown that homeless individuals Department (ED). Previous studies Emergency Homeless individuals frequently use the with either mental health/substance use and injuries related to violence. who visit ED are more likely to present homeless individuals presenting with mental health symptoms. edge exists about the triage process for treatment in the ED compared to non-homeless individuals. whether homeless individuals receive different the 2009-2017 National Hospital and data for individuals age 18 and up from to those living in a private residence. Ordinary representative sample of U.S. ED visits. Homeless individuals were compared individuals for triage, wait time, and length of least squares regression tested differences between homeless and non-homeless including laceration, general pain, chest pain, visit outcomes. Separate regression models were run for specific symptom groups, the person was seen in the ED in the previous headache/migraine, and mental health, adjusting for age, sex, race, and whether encounters including only those listed as homeless or living in a private residence The sample includes 51,166 patient 72 hours. Adjusted models showed homeless individuals presenting with general pain waited 13.6 and those in the above symptom groups. visits (95% CI: 12.6, 75.1, p=0.006) than non- minutes longer (95% CI: 2.16, 25.0, p=0.020) and had 43.9 minutes longer total had 141.5 minutes longer total visit length homeless individuals. Homeless individuals who presented for mental health reasons There were no differences in wait time between homeless and (95% CI: 51.6, 231.5, p=0.002) than non-homeless individuals. bias in triage or wait time among homeless individu Also, there were no differences in triage. Preliminary findings do not suggest Hijab Ahmed, MS; Jeff Dennis, Ph.D Hijab MS1-2 AHMED, HIJAB MS1-2 AHMED, among homeless and non-homeless individuals department care Examining potential bias in emergency School: School of Medicine School: School of Medicine presenting symptoms. als in the ED, consistent for both more and less urgent Takotsubo Takotsubo cardiomyopathy, named for its distinctive ballooning of the left ventricular apex, is characterized a by transient stress systolic and induced diastolic left heart ventricular dysfunction condition with a variety of regional wall-motion abnormalities. In some cases, it can be misdiagnosed as an acute myocardial infarction. Case Presentation: 71 year old female with a history of hypertension, liver dysfunction, and thrombocytopenia presented to the ER for she weakness, fatigue, and fever, watery day, diarrhea. She next The elevated. as biomarkers cardiac her showed EKG Her own. its on resolved that pain chest severe of episode an had was taken to the cath lab for invasive studying. Following the cath, she developed hypotension and narrowing pulse pressure with TheTTE JVD. patientshowed also pericardial exhibitedeffusion severe with ventricular tamponade systolic physiology. dysfunc- was cardiomyopathy and cardiovascular surgery Takotsubo She was diagnosed with apical aneurysm of LV. tion, as well as a large consulted for an emergent pericardial window for cardiac she tamponade. The had next to day, undergo an emergency sternotomy for evacuation of the hemopericardium. like Discussion: cardiomyopathy, Takotsubo an acute myocardial infarction (AMI), is an and TCM However, obstruction. arterial coronary a of absence from AMI an from distinguished be can that syndrome cardiac acute AMI may have certain correlations AMI that have not yet been discovered. On the other TCM hand, can the present fact as that an along with evidence showing that these can occur simultaneously can complicate the workup of a patient. If a risk patient at patient a put also but expense, unnecessary an has be only not can catheterization cardiac TCM, like procedure invasive an undergoing for complications. Dixon, Timothy, MSIV, Dhir, Nikita, MSIII, Agusala, Veena, MSI, Mateja Kirby, MSI Kirby, MSI, Mateja Veena, Agusala, MSIII, Nikita, Dhir, MSIV, Timothy, Dixon, MS1-2 AGUSALA, VEENA AGUSALA, MS1-2 71 year old Female in a Infarction Acute Myocardial as an Presenting Cardiomyopathy Takotsubo

ABSTRACTS 50 School: SchoolofMedicine Pathol. 1976;3(5):239-44. Cutan J report. case Aartifact? or phenomenon natural glands: sebaceous of extrusion Transfollicular DA. Weigand^1. when reportedwaslimitedto onlyasmallareaontheback.^1 licular elimination of sebaceous glands seen on histology. This unique presentation has been scarcely published in the literature, but This patient’s case is significant due to the widespread area of involvement, lengthened clinical presentation, and the global transfol- the findingofpityrosporum and hasledtomildimprovement. A courseoforalisotretinoinistheplanned next stepintreatment. to due fluconazole with started was confirmed. Treatment was infundibulofolliculitis recurrent and disseminated of diagnosis The GMS stain. sebaceous unit with chronic perifollicular inflammation and intracorneal neutrophils. Rare pityrosporum yeast were identified with plete transfollicular elimination of the sebaceous unit through the epidermis. The biopsy also showed an occluded dilated follicular com- for significant was examination Histologic diagnosis. prior confirm to performed was papule one of biopsy punch mm A3 of resolution without but papules. pruritus of relief mild with tretinoin and doxycycline, steroids, oral steroids, topical with treated been previously had He follow-up. to lost was but infundibulofolliculitis later and eczema papular with diagnosed previously was He legs, and elbows. He reported the papules first appeared when he was deployed in Afghanistan and are worsened by heat and sweat. A 37-year-old male presented to clinic with a 15-year history of >300 pruritic perifollicular papules on his back, buttocks, chest, TX Dermatology,Lubbock, of Department Center, Sciences TexasHealth ^3 TechUniversity TX; San Antonio, Medicine, of School ^1 Texasof TexasUniversity ^2 Lubbock, TX; TechSan Medicine, Center,Health of Sciences School Health Antonio, University Mahmud Alkul BS,^1 Austin SmithBS,^2Jay Truitt MD,PhD,PharmD,MPH,^3MichelleB Tarbox MD^3 Transfollicular EliminationofSebaceousGlandsinaPatientwithDisseminatedandRecurrent Infundibulofolliculitis MS1-2 ALKUL,MAHMUD School: SchoolofMedicine in elderlyindividualsandreversesubjectswithmildcognitiveimpairmenttoanon-dementedstate. findings strongly suggest that an improved lifestyle can delay chronic diseases and dementia progression and reduce the risk of AD survey our Overall, individuals. elderly in AD and dementia of progression the delay ultimately diseases kidney and diovascular car diabetes, 2 type as such factors risk metabolic reduces exercise Regular progression. disease delay Tau)and phosphorylated and (Abeta pathologies reduce AD diet enriched antioxidants and/or healthy that revealed of AD models mouse on Data patients. also but AD individuals elderly in only not progression dementia delay diets healthy that revealed literature current of survey Our calorie as such interventions restriction, andvariousbioactivecompoundsoncognitivedeclinedementia. nutritional on data assessed also Wediseases. kidney and cardiovascular and/or diabetes 2 type as such factors risk metabolic and environmental genetic, on data severity, clinical with different along with and patients viduals AD indi- elderly models, animal in exercise and supplements diet and/or diets healthy Weincluding factors, lifestyle on data collected chronic diseases.Ourstudyalsocarefullyassessedgenetic,environmental,metabolicriskfactorsthatimpactdementia. of our study is to critically assess lifestyle factors, such as heathy diets and regular exercise that affect progression of dementia and dementia, or a combination of types. Alzheimer’s disease (AD) is the most common disease associated with dementia. The purpose mixed disorders, vascular dementia, frontotemporal dementia, body Lewy including dementia, of types different many are There United States. Dementia is the characterized by as memory such problems, lifestyles, impaired communication everyday abilities, in and impaired changes undergoingreasoning faculties. are that countries few very a in except worldwide increasing is Dementia Lubbock, TX 79430,UnitedStates;*Kiran Ali andNehaSawantwillbethepresentingauthors 9424, MS Street, 4th Center,3601 TexasSciences Departments, Health Sciences Tech University Hearing and Language Speech, 1.Internal Medicine Department, 2. Pharmacology & Neuroscience Department, 3. Neurology and 4. Public Health Department, 5. LisaAnn Gittner4,HafizKhan4and P. HemachandraReddy1,2,3,4,5 Kiran Ali1*, Neha Sawant1*, Subodh Kumar1, Murali Vijayan1, Bhagavathi Ramasubramanian1, Pradeepkiran Jangampalli Adi1, Is Alzheimer’s aLifestyleDisease: A Critical Assessment? MS1-2 ALI,KIRAN - 51 ABSTRACTS - School: School of Medicine looked until incarceration or strangulation occurs. This case highlights the importance of early identification and exploration of this of exploration and identification early of importance the highlights case This occurs. strangulation or incarceration until looked rare hernia. Conclusion: Spigelian hernias comprise 0.1-2% of all abdominal hernias, with the incidence of appendicitis within the hernia even over be may that symptoms unspecific vague, with or asymptomatically, either present often hernias these Additionally, rare. more Results: Patient presented to the ER on September 4, 2019 complaining of onset of RLQ abdominal pain 1 week ago and decreased decreased and ago week 1 pain abdominal RLQ of onset of complaining 2019 4, September on ER the to presented Patient Results: appetite. He had a history RLQ hernia for 5 years with minimal discomfort. Labs revealed patient leukocytosis the of where 16.25 with A left shift. day, same that surgery of time the at confirmed was This hernia. Spigelian a within appendicitis identified scan CT underwent an exploratory laparotomy for appendectomy and repair of the Spigelian The hernia. appendix was found to be grossly necrotic and perforated, with purulent fluid in the hernia sac. Patient had post-operative ileus, but otherwise had an uneventful re- on September 13, 2019. and was discharged covery, Methods: We present a case of a 66-year old male who underwent exploratory laparotomy in September 2019. Data and information and Data 2019. September in laparotomy exploratory underwent who male old 66-year a of case a present We Methods: intrahospital course, and post-operative care. were collected via chart review of EMR at UMC from the initial ER visit, the Objective: To present Objective: an To atypical presentation of a rare condition of gangrenous appendicitis contained within a Spigelian hernia, management. with a thorough review of the literature and discussion of surgical Introduction: Spigelian hernias are a rare type of hernia which can commonly contain abdominal wall contents such as the bowel. It is defined as a facial weakness at the Spigelian aponeurosis between the linea semilunaris and rectus abdominusmuscle. It can often go unnoticed as it Treatment does not cause the patient any significant or specific distress other than general abdominal pain. intervention. involves surgical Rohan Anand, Jasmin Rohan Rahesh, Caroline Chung, Karla Abbie Esparza Schuster MD, MD, Roy Jacobs MD, Steven E. Brooks, MD A. Ronaghan, MD FACS Catherine FACS, MS1-2 ANAND, ROHAN MS1-2 ANAND, a Spigelian Hernia Appendicitis Contained within Gangrenous

School: Graduate School of Biomedical Sciences School: Graduate School of Biomedical Among the four blocks that comprise the first-year medical school curriculumTechTexas at University physiol- covers Health which (MOS), Systems Organ Sciences Multiple in worst performed students medical 2022 Center of class the Medicine, of School the for challenging most the was NBME physiology the year, first the in taken exams NBME four the of out this, to addition In ogy. medical students. Because the study of physiology deals with complex interplay of many variables, we hypothesize fill-in concept maps to be the ideal at-home studying modality to facilitate both active and integrative learning. Fill-in concept maps have shown promise in the past, packet but of have 16 not fill-inyet concept been maps,studied cov- A or applied on the medical school level. ering the foundational material taught in unit one of MOS, was provided to the class of 2023 medical students. Each concept map came in two forms: 1) partially completed (containing a key box) to be filled in by the student and 2) fully completed to be used to expand on students were also directed The medical to concept maps themselves in order the fully completed as an answer sheet. facilitate training in concept map the development. medical Lastly, students were provided with 20 practice questions to test their overall proficiency of unit one material. Survey results from the class of 2023 first-year medical students indicate that theconcept maps were fill-in a useful studying tool in integrating understanding the physiology, concepts, and retaining the information. In addition to this, a majority of the respondents felt that the fill-in concept maps prepared them to answer the practice questions pro- developing begin to students the influenced maps concept fill-in the that indicating correlation no was there However, them. to vided of the block. concept maps of their own for the remainder Joey Almaguer and John Pelley, Ph.D. John Pelley, Almaguer and Joey MS1-2 ALMAGUER, JOEY ALMAGUER, MS1-2 in Medical Education Integrative Learning Active and of Maps as a Method Fill-In Concept

ABSTRACTS 52 School: School ofMedicine to LCDC administrationaboutwhether additionalresourcesareneededtoaddressPTSDin theiremployees. recommendations make to as well as PTSD, to relation their and environments work stress chronic of understanding national to contribute to aim Findings extremely). 4= to all at not (0= 0-4 from ranging scale Likert 5-point a on experience stressful most their by month past the in bothered been have they much how rate Participants population. this in PTSD assess to scale, 20-item a the mental health of LCDC employees. This study will administer the Posttraumatic Stress Disorder Checklist for DSM-5 (PCL-5), impact exposures traumatic how understand to setting ideal an provides LCDC such, as and environments, stress chronic on less tional staff may lead to increased tensions and stress for employees. Research on Posttraumatic Stress Disorder (PTSD) has focused correc- to proximity close the inmates, for effects beneficial have to shown been have supervision direct of freedoms the Although shift. a during own their on inmates 70 to up supervise may staff facility,LCDC supervision direct a areas. As surrounding some and County Lubbock serving inmates, 1,500 of capacity a with population jail co-ed a houses (LCDC) Center Detention County inmates with intellectual and developmental disabilities, and special populations such as veterans and gangmembers. The Lubbock diverse population of incarcerated individuals, including violent offenders, inmates with mental illness and substance use disorders, Detention center officers and associated employees are tasked daily with working in the confines of adetention facility to manage a Ludwig, CameronDavid.Poch,Ryan Matthew. Marie. vonRoeder, NathanLewis Jaclyn Jones, Celeste. Paloma Flores, Makala. Sarah Bayless, PhD. Alan, Jeffrey Dennis, PhD. Schelli, LisaAnn Gittner, Pilot studyofPTSDinLubbockCountyDetentionCenteremployeesusingthePCL-5 MS1-2 BAYLESS, SARAH School: SchoolofMedicine tive sickcontacts.Rapiddiagnosisandearlytreatmentarecrucialfortheoutcomeof have nega- patients thatseemto young tuberculosis, even in for suspicion index of high maintain a the needto highlights case Our steady improvementoftheleft–sidedweaknessandeyedeviation. patient’s leukocytosis and CSF pleocytosis had improved with the start of the four-drug therapy and steroids, and the The patient started. was showed dexamethasone and ethambutol, and isoniazid, rifampin, pyrazinamide, of regimen anti–TB appropriate tion. An infec of source the be patient’sto the determined investigation, was initially,contact grandfather concerns and diagnosis after but diagnosis. no the revealed confirming possible exposures induration, for TB mm history 10 exhaustive had An and placed was test skin (PPD) malignancy. Derivative for Protein negative APurified tuberculosis, with consistent granulomas caseating necrotizing lobe mass. As bacterial and viral cultures remained negative, and thepatient was notimproving, a lungbiopsywasdoneandshowed ment concerning for tubercular meningitis; a chest CT was done and showed a right–sided hilar mass contiguous with a right upper enhance lepto–meningeal with mass brain a revealed (MRI) Imaging Resonance Magnetic with Imaging deviation. eye bilateral On the subsequent visit, the patient developed a left–sided upper and lower extremity motor weakness, left–sided loss of DTRs, and initiated. were phenytoin and antibiotics spectrum broad Empiric pathogens. viral for tests serologic and cultures viral and (AFB), bacilli acid–fast fungal, bacterial, agents, viral for studies (CSF) fluid cerebrospinal included evaluation laboratory Initial cytosis. leuko- revealed differential with count blood complete and 147) protein 12, glucose lymphocytes, 96% with 99 (WBC pleocytosis tomography (CT) scan revealed hydrocephalus and an external ventricular drain was placed at our facility. Lumbar puncture pneumonia. for Ashowed computed treated head and diagnosed being grandfather her than other contacts sick no had She NM. Hobbs, in Infectious Disease clinic after 2 episodes of focal–like seizures and vomiting after feeds when she was seen at a community hospital the Texasto transferred was who female Pediatric Techfour–month–old Center Wea Science of Health case University the report the availabilityofadvancedhealthcare. despite complications and sequelae neurological have or TB with die patients meningitis TB the of 50% than more States, United the of areas certain In tuberculomas. as rarely more much and hydrocephalus, meningitis, tuberculous as commonly presents dren TB meningitis remains an unusual cause of meningitis in children in the United States. Central nervous system tuberculosis in chil under-developedamongst Tuberculosisprevalence its of much with countries; tuberculosis, Mycobacterium by caused disease a is Sabiha Armin BS;FatmaLevent, MD TB meningitis. - - - 53 ABSTRACTS - School: School of Medicine Conclusion: The results of this study will guide an evidence-based suggestion aimed at improving the rate of reported cases so that so cases reported of rate the improving at aimed suggestion evidence-based an guide will study this of results The Conclusion: is they more an accurately important represent indicator of the true morbidity and number of mortality in cases. the NAT pediatric to minimize Appropriate screening measures are critical in the hospital setting. population that can easily be over or under-indicated patients. unnecessary emotional trauma to families and prevent premature death in pediatric Results: A total A Results: of 97 charts fit the criteria for Of review. these, all 97 patients were and screened 42 for (43.3%) NAT were con- analysis is in progress. ruled out. Statistical while the other 55 had NAT firmed NAT Methodology: The Methodology: trauma fromregistry 4/1/17identified to (n=97) 3/31/19 patients and admitted a for chart diagnosis re- of NAT socioeconomic NAT, true diagnosis, final admission, for used criteria screening including interest of Variables conducted. was view factors (age, sex, insurance, ethnicity/race), and final disposition were compiled and estimated using descriptive statistics such as median, and distribution patterns. mean, frequency, Introduction: Non-accidental trauma (NAT) is a leading cause of injury and screening procedures are death implemented by all for physicians; however, cases some are true children still NAT child A undetected. who returns in the United States. Common to their residence without intervention after a medical appointment can have an increased risk of mortality from 11 to 50%. Lub- relatively a has it though even years, ten past the in victims abuse child of number for 254 of out 14 number ranked is County bock that screening under or over of level the determine to is study this of goal The counties. surrounding several than population smaller is being performed at Covenant hypothesized Hospital. Children’s We that pediatric patients at Covenant Hospital Children’s are for NAT. being over-screened Celeste Hollands, MD - Associate Professor of Surgery at Texas Tech University Health Sciences Center in Lubbock, Texas, Texas, University Health Sciences Center in Lubbock, Tech Texas at Associate Professor of Surgery Celeste Hollands, MD - School of Medicine TTUHSC with MPH, MS2 Summre Blakely, Evaluation of Current Screening Effectiveness in Non-Accidental Trauma Cases Effectiveness in Non-Accidental Screening Evaluation of Current MS1-2 BLAKELY, SUMMRE MS1-2 BLAKELY, School: School of Medicine thopaedic lower extremity arthroplasty procedures is still uncommon, further research is needed to examine the efficacy of UBM in this setting. BACKGROUND: BACKGROUND: Acellular Dermal Matrix (ADM) has been used since their inception in 1992 to treat burn injuries, abdominal wall reconstruction and breast reconstruction. The purpose of ADM is to provide a non-immunogenic scaffold to promote tissue ADMs ADMs are cre- not ideal to native tissue regeneration granulation because and re-vascularization of native tissue. However, ate a dense, fibrous, acellular core that does not permit native tissue and cells tointegrate into the scaffold. Urinary bladder matrix ADMs, but also permits (UBM), a porcine extracellular matrix (ECM) scaffold maintains similar tensile and sheering properties to - fibro and growth cell nerve stimulates and tissue underlying protect to serves penetration cell Epithelial penetration. cell epithelial blast migration while minimizing 52-year-old wound A female contraction. with CASE a REPORT: history of multiple irrigation and drainage procedures of a left total knee arthroplasty over a one-year period presents with a recurrent seroma the on both in UBM the of mg 1500 left of placement and knee seroma the of excision surgical underwent patient The prior. week one ruptured that medial and lateral gutter of the At left the knee. time of the operation, the wound bed was 15 cm (L) x 5 cm (W). at However, the and irrigation underwent and drainage exudative continued with clinic the to presented patient the appointment, follow-up six-week drainage of the seroma. During the procedure, the wound bed size reduced from 15 cm x 5 cm at the initial operation to 9 cm x 4 cm. CONCLUSION: In this case, UBM demonstrated success in decreasing the wound bed size and may prove useful in patients who struggle with post-operative wound closure by first intention through several mechanisms. Given that the use ofUBM in or Brendan MacKay, MD; Patrick Bettiol, MBA; Chris Gerzina, MD; Cameron Cox, BBA Cameron Cox, Chris Gerzina, MD; Patrick Bettiol, MBA; MD; Brendan MacKay, MS1-2 BETTIOL, PATRICK BETTIOL, MS1-2 Patient Arthroplasty Knee Total in a Seroma Post-Operative ECM Scaffold to treat of a Porcine Novel use

ABSTRACTS 54 School: SchoolofMedicine We presentacaseofbilateral cephalohematomawithscaphocephalysecondarytoprogressivesagittalcraniosynostosis. are potentially associated, either through mechanical pathways involving trauma or through a complex interplay of growthfactors. of scaphocephaly with bilateral cephalohematoma as of the date of this report. The current literature suggests that the two conditions reports no and cephalohematoma and craniosynostosis sagittal to due scaphocephaly both with patients of reported cases few very been have There procedures. Section Caesarian in injuries fetal reported frequently most the of one is and delivery ment-assisted and structural problems. Cephalohematoma is a subperiosteal collection of blood commonly associated with birth trauma or instru- Inappropriate fusion of the cranial sutures leads to craniosynostosis and the subsequent skull rigidity can cause many developmental Bilateral CephalohematomawithSagittalSynostosisandScaphocephaly: Texas Tech UniversityHealthSciencesCenter, DepartmentofPediatrics,Lubbock, TX Avery KopaczBS,LaszloNagyMD,JoshuaDemkeandMichaelCareyMS Bilateral CephalohematomawithSagittalSynostosisandScaphocephaly MS1-2 CAREY, MICHAEL School: SchoolofMedicine of improvementfortheprogramareincreasingfemaleandminorityparticipation. areas Possible time. prison to leading use substance of cycle the of out break offenders many helped has Court Drug Lubbock The Possible causesincludeparticipantdeclinedparticipationandcriminalhistorycausingineligibilityforparticipation. Latino and female involvement reflects low levels of minority and female enrollment seen in drug court programs across Hispanic/ the decreased county. The program. the in time spending of benefit the indicate could recidivism terminate in decrease The size. in rates. The stable recidivism rate among graduates indicates that the quality of the program has stayed the same, despite the increase graduation in drop the to led have could Together,factors participants. two risk these higher of enrollment the enabled has courts more two of addition The evaluation. previous the in than people more 408 graduating significantly, expanded has program The pants decreasedfrom36.9%to13.0%. partici Hispanic/Latino 32.2%. to 42.6% from dropped participants women of percent the and 720% by increased participants of to 16.8% from 19.6%, and the recidivism rate among program terminates dropped significantly from 66.7% to 39.9%. The number The graduation rate decreased from 65.6% to 56.5%, while the recidivism rate among graduates stayed roughly the same, dropping sis wasperformedusingSPSS-16. Demographic and outcome statistics on 864 participants from 2009-2017 were obtained from drug court administrators. Data analy demo- and outcome graphic statisticsoftheprogramfromlastreportdonein2009. the compare and update to seeks project This 2005. in court drug a of establishment the to leading County, vism, saving communities money in the long-term. Drug-related crimes and substance use treatment are large issues in Lubbock recidi and use drug of rates lower of reports to due country the across prevalent increasingly becoming are programs court Drug Ellen Brown A ReviewoftheLubbockCountyDrugCourtProgram MS1-2 BROWN, ELLEN - - - 55 ABSTRACTS - - Al-Rahawan, MD^2. School: School of Medicine Conclusion: The success of Vemurafenib Conclusion: and The in Dabrafenib/Trametinib success causing of Vemurafenib pediatric CNS tumor regression is promising, but further studies are needed. mas. However, mas. more However, research has shown that various pediatric CNS tumors are BRAF-V600 positive. Therapy with these BRAF successful with patient one shows series case This severe. be can toxicity but progression, tumor slow to shown been has inhibitors progression subsequent but response initial with patient one and stabilization, disease prolonged with patient one regression, tumor and ultimate death. It has been shown that using BRAF inhibitors in lower grade CNS tumors are more effective than higher grade CNS tumors. Discussion: Vemurafenib, Dabrafenib, and are Trametinib Discussion: Vemurafenib, BRAF-V600E/MEK inhibitors that were initially used to treat melano Methods: We followed Methods: the We disease course, progression, and treatment of three pediatric patients with three different CNS tumors. Each of these individuals was treated with surgical resection, and/or chemotherapy, radiation as per standard protocol. When that were they and positive BRAF-V600E was tumors different their of each that found we progression, tumor reduce to failed modality therapy. all started on targeted Objective: Current pediatric CNS brain tumor treatment focuses on chemotherapy and radiation, causing significant toxic positive side BRAF-V600E ef- in therapy targeted using experience our relaying in lies series case this of significance The patients. for fects CNS pediatric brain tumors. Background: The BRAF-V600E gene is a protein kinase involved in regulation of the mitogen activated protein kinase pathway (MAPK/MEK) and downstream extracellular receptor kinase (ERK). The BRAF-V600E mutation progression of pediatric brain tumors. 85% has of pediatric CNS tumors express the BRAF Thus, mutation. BRAF a therapy targeted in significant role in the expressing this mutation. pediatric CNS malignancies has potential to become the standard of care for tumors 1 School of Medicine, Texas Tech University Health Uni- 1 Sciences Tech Lubbock, TX; School Center, 2 Tech of Department Medicine, Texas of Pediatrics, Texas TX Lubbock, versity Health Sciences Center, Sheila Chandrahas^1; Nikita Dhir^1; Chibuzo O’Suoji, MD^2;Mohamad M. Sheila Chandrahas^1; Nikita Dhir^1; Chibuzo Treatment of Three Different BRAF-V600E Positive Brain Tumors with Vemurafenib and Dabrafenib/Trametinib: A Case Series Vemurafenib and Dabrafenib/Trametinib: Tumors with Positive Brain BRAF-V600E Different of Three Treatment MS1-2 CHANDRAHAS, SHEILA MS1-2 CHANDRAHAS, School: Graduate School of Biomedical Sciences School: Graduate School of Biomedical tion. Histological analysis revealed SOM:tdT expression in the DG inner molecular layer (IML) of AD, but not WT mice. SOM:tdT SOM:tdT mice. WT not but AD, of (IML) layer molecular inner DG the in expression SOM:tdT revealed analysis Histological tion. expres- SOM:tdT However, phenotype. of rescue a with consistent mice, AD RT male 5/6 of IML DG the in absent was expression com- pairwise Transcriptomic signaling. RA in differences sex indicating persisted, mice AD RT female 3/3 of IML DG the in sion the within particularly genes, expressed differentially of normalization partial showed AD and WT RT to AD and WT VT of parison AD pathogenesis among males. effects against to have protective appears CONCLUSION: RA Synaptogenesis Signaling pathway. sex. and age by matched group per mice of size sample larger a involving investigation further warrant observed differences sex The INTRODUCTION: Vitamin A (VA) signaling disruption is observed in Alzheimer’s disease (AD). Deficiency of retinoic acid (RA), acid retinoic of Deficiency (AD). disease Alzheimer’s in observed is disruption signaling (VA) A Vitamin INTRODUCTION: metabolite, may contribute to hippocampal dentate gyrus (DG) hyperactivity seen in the amnestic mild cognitive impairment VA a stage of AD and alter excitation/inhibition (E/I) balance. Intact normally inhibitory maintain E/I balance, but somatostatin the impact of on RA DG (SOM) SOM and PV circuitry and has not been investigated. parvalbumin OBJECTIVE: The (PV) circuits METHODS: pathogenesis. AD during circuitry PV and SOM DG on RA of effect therapeutic the evaluate to was study this of goal transgenic Triple J20+/- (AD) mouse models were generated, enabling examination of SOM and PV circuitry via (tdT) tdTomato (WT) J20-/- age-matched to compared and intraperitoneally (VT) oil corn or (RT) RA with treated were models Mouse expression. controls. Behavioral testing was done in and the open Y-maze field maze. Brains were then hemisected for histological and tran- AD Behavioral mice testing traveled scriptomic VT revealed a AD analyses. greater mice RESULTS: distance (U-5.000, than WT AD and WT p=0.009). mice RT did not vary in overall distance travelled (U=16.000, p=0.727), suggesting phenotype normaliza Karen Castaneda, Anthony Brent J. Krisby, Pascullo, Robert Barnes, Jeremy D. Bailoo, PhD, Igor PhD, Ponomarev, J Josh Law- rence, PhD. MS1-2 CASTANEDA, KAREN CASTANEDA, MS1-2 disease Alzheimer’s of novel mouse model acid signaling in a retinoic by disruption inhibitory circuit from protection Sex-specific

ABSTRACTS 56 School: School ofMedicine presenting with unilateralpainandnoradiographic evidenceofinjury athletes rodeo for consideration clinical additional an that provides study This evaluation. arm clinical during account grip into taken be should the in occurring are stress high to response in changes anatomic Significant hypertrophy. tissue soft concurrent as nerve compression on exam. These athletes showed a greater degree of bony hypertrophy than athletes of other disciplines, as well peripheral of signs injury,and of evidence radiographic no pain, arm grip with presented riders stock rough Rodeo Conclusions: 268.5%). Clinicalphotographsalsoshowedsofttissuechanges consistentwithwhatisexpectedinanarmbearingincreasedload. measured 42.3% (n = 17, range: 4.7-92.0%), and projected cross-sectional area increase was recorded at 106.8% (n = 17, range: 9.6- Results: The mean ratio of grip to free arm ulnar diameter was 1.42 (n = 17, range: 1.05-1.92). The mean diameter percent increase Diameter Increase,andPercentageProjectedCross-Sectional Area Increase wereallcalculated. the diameter of bilateral ulnas was measured at its longitudinal midpoint. Ratio of Ulnar Diameters (grip arm/free arm), Percentage Methods: AP and lateral x-rays of 17 bareback rodeo athletes were reviewed. Ulnar hypertrophy was observed in the grip arm, and had beendemonstratedinpreviousstudiesreportingonathletes ofothersports. the griparmintheserodeoathletes woulddemonstrate bony hypertrophyandosseouschangescompared to thenon-griparmasthey The patients evaluated presented with chronic arm pain, and radiographs were taken during initial evaluation. We hypothesized that this effectinrodeoathletes,however, isminimal. addressing literature The tennis. as such limb single a of utilization significant requiring sports in athletes of arm dominant the in Purpose: Wolff’s Law states that bones remodel to increase size and density in response to greater stress. This has been documented Nathan ChowBS,ChristianDouthitMD,CameronCoxBA,RickFosterMS,BrendanMackayMD Forearm Hypertrophy inRodeo Athletes MS1-2 CHOW, NATHAN School: SchoolofMedicine bring awarenesstothisdiseasebyemphasizingitspresentation,riskfactors,andearlytreatment. to is report this of aim The California. following incidence Moreover,highest States. second Texas United the the has in botulism of type growing fastest promptly.the treated is not disease if This mortality high a has botulism Conclusion: infant rare, Although C. botulinumtoxintype A, confirminginfantilebotulism.Sourcewasnotidentified. increased activity, muscle tone, and feeding ability. After 6 days, the patient was discharged. Stool sample analysis was positive for had patient later,the days Five admission. after day next the given was BabyBIG of administration and analysis, toxin botulinum for sent was abnormalities. sample Ano stool showed (MRI) imaging resonance magnetic brain a and limits, normal within were (CBC) count blood complete the from values laboratory count, platelet high a vomiting. from or Aside rash, fever,congestion, no velopmental milestones. Upon presentation, the patient had hypotonicity, bilateral ptosis, drooling, and weak cry. However, she had de- physical of regression and sucking, poor constipation, of Lubbock, Texashistory in 2-3-week Hospital a Pediatric with Center Case Presentation: A 4-month-old female from Seminole, Texas was brought into the emergency department at University Medical infant botulism is suspected, it is highly recommended to begin treatment immediately rather than wait for laboratory confirmation. infection. after If days treatment. 8 for to available hours is 4 A(BabyBIG) between Intravenous Globulin Botulism of dose single present can cry weak and ptosis, bilateral paralysis, descending of Symptoms contact. wound or ingestion, inhalation, via infected aerobic microorganism is mainly found in soil, honey an- products, and forming, canned spore food. Individuals, This ages toxins. 3 botulinum weeks – Clostridium 6 by months, can caused become disease neuroparalytic lethal, a is botulism Infant Background: Danielle ChowandDr. FatmaLevent A CaseofInfantBotulism MS1-2 CHOW, DANIELLE . 57 ABSTRACTS - - - - At Texas Tech University Tech At Health Texas Sciences Center School of Medicine, the curriculum begins with a rigorous Clinically Oriented portion A of Anatomy course. this course which includes is embryology, taught using standard lecture model favor along with was a sheet faculty fact yield high the of perception student’s medical year first though, Even sheet. Fact Yield High Embryology made R. Boone Coleman, Dr. Brandt Schneider, Dr. Gurvinder Kaur Dr. Schneider, Brandt R. Boone Coleman, Dr. MS1-2 COLEMAN, BOONE MS1-2 COLEMAN, of embryological development in first year medical school curriculum applied to first four weeks Active learning resources School: School of Medicine School: Graduate School of Biomedical Sciences mone (TSH). This suppression of TSH resolves by second trimester. For cases in which hyperthyroidism and TSH suppression fail suppression TSH and hyperthyroidism which in cases For trimester. second by resolves TSH of suppression This (TSH). mone present to resolve, physicians are challenged to balance the treatment of thyroid imbalance and health of We the developing fetus. a case report of hyperthyroidism in a patient that lasted past first trimester that has successfully resolved without interven medical lab hormone thyroid scan, US thyroid included test Diagnostic healthy. otherwise but lethargic be to her found exam Physical tion. Standardiza of results. interpretation with difficulty in result can this ranges; specific trimester on based report labs all Not studies. tion of trimester specific The thyroid case hormone also ranges highlights on how reports effective should patient be implemented. endocrinology and OB/GYN teams. close joint clinical management between management requires concepts, of key embryology retention higher achieve To thinking. critical to stimulate on its own fails and of facts, is a list it able, our objective is to transform the passive experience of reading a document, to an active and achieve engaging this experience. To objective, topics covering the first four weeks of embryological development which includes content suchdevelopment, ascellular fertilization,differentiations, early gastrulation, neurulation, cardiac looping, and cardiac defects wereTo selected. stimulate active learning, resources including Flashcards, Formative self-assessment questions (N=30) with answer analysis, Pre-unit exam content and review, a Pre-National Board of Medical Examiners (NBME) exam content review were created and provided to the regards with exam NBME and in-house on performance class current the resources, these of effectiveness the evaluate To students. to embryology was compared to last year’s class performance. Although, the current class performance on in-house not significantlyexams different, theirwas performance on NBME was improved compared to last year’s class. In addition, survey data was collected from 114 students using a 5-point Likert scale over the perceived helpfulness of the active learning Approxi- materials. on better 40.6% scored students Additionally, learning. for helpful were resources the that stated respondents survey of 95% mately post-test questions compared to the pre-test. Overall, this data strongly suggests that using active and engaging resources will help students in effectively learning and retaining embryology. In healthy pregnant women the human chorionic gonadotropin hormone (hCG) has been shown to suppress thyroid stimulating hor stimulating thyroid suppress to shown been has (hCG) hormone gonadotropin chorionic human the women pregnant healthy In Victoria Chu, Jasmin Rahesh, Dr. Cornelia De Riese, Dr. Alan Peiris Riese, Dr. Cornelia De Rahesh, Dr. Chu, Jasmin Victoria MS1-2 CHU, VICTORIA CHU, MS1-2 and OB/GYN Collaboration Endocrine Case Report Highlighting A - Pregnancy Dysfunction During of Thyroid Management

ABSTRACTS 58 School: GraduateSchoolofBiomedical Sciences trointestinal andEndocrineportion ofthefirstyear’s Physiologycourse. project. this of ness project’sGas- the the on for Aemphasis tool an learning with a conducted as be utilization will analysis needs effective the test to module the in covered material the of grasp their evaluates that post-test and pre- a take will students medical also module students’the This track to year questions First vignette-style project. includes the of utilization the during material the of form. understanding visual a in presentations clinical alongside module learning a produce to Pro Premiere Adobe and 2016 PowerPoint Microsoft used I test. (NBME) Examiner Medical of Board National students’and the exam for in-house information and treatments as suggested by the American Diabetes criteria Association. diagnostic By creating appropriate this module, the I hope and to increase mellitus the recall diabetes of relevant of causes pathophysiological the emphasized also and I metabolism. regulation, glucose and synthesis glucagon and insulin composition, pancreas endocrine of consists project This curriculum. school cal vignettes, that is a supplementary, self-paced study guide to the diabetes lectures covered in the Physiology block of the medical of delivery for this information to stimulate active learning. I have created an online learning module, incorporated with video clini in the basic science courses are challenged with digesting a plethora of information. Learning modules have been an efficient route disease, several areas of this illness are covered throughout the first and second year of medical school curriculum.this Medicalof students application clinical the and patients amongst pre-diabetes/diabetes of incidence high the of year.Because every increasing cases undiagnosed and diagnosed both of number today,total care the primary with in cases prevalent most the of one is Diabetes Roald Credo,JannetteDufourPh.D. Efficacy oflearningmoduleswithvideoclinicalvignettesondiabetesforfirstyearmedicalstudents MS1-2 CREDO, ROALD School: SchoolofMedicine vention, totalcostoftreatment,andmortality. after (n = 43). Primary study variables include amount of CroFab used (vials), hospital and ICU days, coagulopathy, surgical inter those to 177) = (n protocol snakebite the of implementation to prior outcomes patient compare to Specifically, aim 2019. we May of this study are to retrospectively analyze 220 snakebite patients that presented to UMC, Lubbock, TX from January 2002 through aims The population. patient large-scale a on evaluated be to yet has protocol This dosing. CroFab approximate to envenomation Center, developedasnakebitetreatment protocol thatassociateslocalandsystemicsymptoms,coagulation studies, andseverityof potential to increase total costs, and decrease overall patient outcomes. Preliminary studies at Texas the has treatment, Tech snakebite inefficient University to Health leads Science care standardized of lack This antivenom. of administration the on providers care health among variability high to addition in envenomation of degree However,and signs the on standardization little very is there complications. sickness serum reducing markedly while procedures surgical drastic for need the eliminated but all has CroFab, as patients to suffer serious side effects such as serum sickness. The current development of antivenom from sheep serum, also known surgery, and finally to more modern snakebite antivenoms. At first the antivenom was derived from horse serum, which often caused aggressive to method, cowboy venom” the out “suck haphazard the from copperhead. Treatmentprogressed and has cottonmouth, rattlesnake, the as such species known well includes that (Crotalinae) viper pit of subfamily a by inflicted are bites these of most States, United the In death. and shock severe to appendages of loss and tissue of necrosis from range that complications including Over 7,000 people are bitten by venomous snakes in the United States every year. These snakebites can pose serious health problems TTUHSC; Armand Northcut,MS1 TTUHSC Dr. John Griswold, UMC Burn Surgery; Jared Covell, MS2 TTUHSC; Grant Sorensen, PhD, MS3 TTUHSC; Nathan Hallier, MS2 ment treatment algorithm. hospital’sone treatment:with Snakebite conjunction retrospectiveA of assess- in CroFab evolution bite use of The snake analysis MS1-2 COVELL, JARED - - - - 59 ABSTRACTS - Tran, PhD; James C. Wang, MD, PhD Wang, PhD; James C. Tran, A Systematic Review A School: School of Medicine ics/antifungals utilized in the treatment of rhinosinusitis. CONCLUSION: Despite differences in 8 methodology, out of 9 studies showed EOs to exhibit antimicrobial effects on sinonasal antibiot with EOs of interactions additive and antagonistic, synergistic, potential explore should studies Future vitro. in pathogens RESULTS: Nine RESULTS: articles were included in the final analysis. These studies evaluated the inhibitory and bactericidal effects of 46 different EOs/EO combinations on 13 sinonasal pathogens. Cytotoxic effects dif- agar on (1), method diffusion 8 fungal disc pathogens Bauer were Kirby (2), also dilution evaluated. broth in Studies (3), form gaseous the in EOs of effects antimicrobial evaluated fusion (4), and microdilution (4) methods. One study evaluated effectthe ofsynergistic EOs when combined with ciprofloxacin or Among the EOs considered to be effective inhibitors of sinonasal amphotericin B, for bacterial and fungal pathogens, respectively. catarrhalis). M. and pyogenes S. aureus, (S. sipyleus Thymus catarrhalis), M. and aureus (S. mixtures oil Melaleuca were: pathogens was capillaris Artemis action. antimicrobial strongest the have to found were oils lemongrass and thyme, cinnamon, generally, More found to be a potent inhibitor of S. aureus. MATERIALS AND METHODS: PubMed, Ovid, Cochrane, and Embase computerized searches were performed through December through performed were searches computerized Embase and Cochrane, Ovid, PubMed, METHODS: AND MATERIALS data extraction following a predetermined protocol. independent reviewers conducted Two 2019. Callie L. Fort, MS, MBA; Jeremy Doan, BS, MBA; Joshua C. Demke, MD; Phat Callie L. Fort, MS, MBA; Jeremy Doan, INTRODUCTION: The purpose of this study is to provide a comprehensive review of in vitro studies that examine the inhibitory pathogens. effects of essential oils (EOs) on sinonasal Inhibitory Effects of Essential Oils on Common Rhinosinusitis Pathogens: Inhibitory Effects of Essential Oils on MS1-2 DOAN, JEREMY MS1-2 DOAN, School: Graduate School of Biomedical Sciences School: Graduate School of Biomedical Globally, about 2.2 Globally, billion people have a vision impairment or blindness and half of them could have been prevented. In the U.S, the leading cause of vision impairment or blindness is primarily due to age-related diseases including diabetic retinopathy (DR). a With growing elderly population, it has become imperative now more than ever to focus on prevention of such ocular diseases. Simple prescription for health called the Life’s Association’s The aim of the American study Heart was to evaluate the relation the National 2005-2008 the in participated who years ≥40 aged adults 6118 from were Data DR. of occurrence the and metrics (LS7) 7 Health and Nutrition Examination LS7 Survey. metrics consisted of information on smoking, physical body activity, mass index, diet, blood pressure, total cholesterol and blood glucose. Scores were summed for a maximum of 14 (most health). Logistic regression was used to estimate adjusted ideal odds ratios (OR) and 95% confidencecardiovascular intervals The (CI). average age of participants was 57 years with 53% of them being women. The prevalence of DR was 5%. In models adjusted for age, sex, race, 0.64- 0.69, 95% CI: odds of DR (OR: 31% reduced a with LS7 scores was associated in increase one-unit a income, and education observed we study, this In imaging. retinal by diagnosis only to limited was DR when persisted association This 0.001). < p 0.74, that the more ideal cardiovascular an health individual’s was as described by the LS7, the lower their odds of developing diabetic ocular preventing in promise hold disease cardiovascular prevent to interventions of use the that suggest findings These retinopathy. diseases such as diabetic retinopathy. Noah De La Cruz, MPHc*; Obadeh Shabaneh, MPHc*; Duke Appiah PhD MPH Appiah PhD Duke Shabaneh, MPHc*; Cruz, MPHc*; Obadeh Noah De La MS1-2 DE LA CRUZ, NOAH CRUZ, DE LA MS1-2 in the U.S Population and Diabetic Retinopathy Simple 7 of Life’s Association The

ABSTRACTS 60 School: SchoolofMedicine of drainagethroughtheshunt system. ing the clinical use of shunts by examining for the first time how the position, length, and coiling of the distal catheter affect the rate length of distal catheter that all surgeons should be using in pediatric cases. In this study we hope to advance the literature discuss- predictable distal catheter lengths and positions that will optimize shunt function for each patient, and and whether specific there is are one standard there whether of question the begs This patients. these in failure shunt even or under-drainage, over-drainage, to contribute could factors these then drainage, CSF of rate the affect peritoneal cavity the in tubing extra the of coiling natural the or catheters distal longer If cases. these in used be should catheter distal excess much how governing practice of standard no is there between the ventricle and the peritoneal cavity increases, there will still be enough distal catheter to reach its destination. However, the peritoneal cavity.the ventricleto the distancefrom span to necessary than is the distance and child grows, the that as so is This catheter distal more in put will surgeons cases pediatric in because interest particular of are variables These drainage. of rate the affecting variables possible as explored be to yet have catheters distal the coiling or bending of effects the catheter,and distal the of length The drainage. CSF of rate the affect also can body the within shunt the of orientation and structure the changing itself, normal range. Abnormal ICP results in significant side effects such as severe headache. Besides changing the posturing of the body the above rise or below ICPfall the cranium, the from evacuated is CSF little too or much too If shunts. hydrocephalic tracranial in- of use clinical the in problem significant a remains under-drainage and over-drainage design, shunt perfect to efforts Despite Stanley Eboh,LauraPerezarnold,Brandon Wei The EfficacyandHydrodynamics of Ventriculoperitoneal shuntvalves MS1-2 EBOH,STANLEY School: SchoolofMedicine defects followingtumorresection. sternal repairing for option a viable be may graft bone crest iliac defects, segmental significant of cases In ineffective. is radiation when plasmacytoma solitary extramedullary treating for method effective an is reconstruction and resection Sternal Conclusions: graft stability, andthepatienthasreturnedtonormalactivities. Results: At 9 month follow up, bone marrow biopsy showed no evidence of multiple myeloma. X-ray, CT, and PFT scans confirmed struction usingiliaccrestautograftintheliterature. recon- sternal of reports no currently are crest. There iliac the from taken graft bone autogenous with reconstruction and resection sternal underwent who plasmacytoma bone solitary extramedullary an with diagnosed patient a of case the Wepresent Methods: reconstruct sternaldefects,andthelimitedpublishedreportsarepromising. to used been recently,have More grafts complications. respiratory bone and pain chronic cause frequently they protection, greater patients undergoing reconstruction secondary to tumor resection, who are otherwise healthy and active. Though rigid materials offer tions following failed sternotomies in cardiac surgery. While these have had some success, they fail to provide adequate support for reconstruc- sternal for used been historically have materials Flexible structures. respiratory and pulmonary for protection adequate for sternal tumors remains low. Resection often results in significant bone defects in the chest wall, and reconstruction must provide rate survival the resection, radical with Even tumors. bone among rare are sternum the of tumors malignant Primary Background: Kyle DrinnonBS,SamirSheraliBA,CameronCoxBBA,BrendanJ.MackayMD Sternal Tumor ResectionandReconstructionUsingIliacCrest Autograft MS1-2 DRINNON, KYLE 61 ABSTRACTS - - School: School of Medicine ganisms surrounded by a protective matrix of extracellular polymeric substance (EPS). Biofilm formation imparts antibiotic toler ance and reduces metabolic activity to the bacteria dwelling inside them and thus contributes to the chronicity of wounds. Nearly hydro- glycoside that shown recently have We infection. biofilm-associated a develop become will wounds diabetic chronic of half lases (GHs) can degrade biofilms by breaking down polysaccharides in the EPS and releasing bacteria from the biofilm. In mouse on is dependent GHs of efficacy the However, bacteria. kill to antibiotics of efficacy the potentiated treatment GH infections wound environ- the and them producing species bacterial the on depending differ can which EPS, the in present polysaccharides of type the we aimed to ment determine in whether which the the biofilmsspecies madeare bygrown. PseudomonasIn aeruginosa this study, in diabetic hypothesized wounds that would PA be as susceptible to GH treatment as those made in We (PA) non-diabetic wounds. PA than GHs of action the to susceptible less or more either was that EPS produce may environment wound diabetic the in growing biofilms from PA disperse to GH of ability the examined we hypothesis this test To environment. wound non-diabetic a in growing caused and mice of types both in bacteria disperse to able were GHs that found We mice. non-diabetic and diabetic of wounds the in septicemia in the absence of antibiotics. when However, administered with antibiotics, septicemia we did not Interestingly, occur. saw increased dispersal in diabetic mice, which did not correlate with the overall number of diabetic of bacteria system immune the in present impairments that or GHs, in to susceptible more are mice the diabetic in biofilms the wound. that indicate could This mice are allowing for the survival of more dispersed bacteria. Chronic infections in both diabetic and non-diabetic hosts are associated with the formation of a biofilm, a community of microor Avery Endsley, MS2, Whitni Redman, Kendra Rumbaugh Whitni Redman, Kendra MS2, Endsley, Avery Antibiotic Treatment with Enzymatic Biofilm Dispersal in Diabetic Mouse Wound Models with Enzymatic Biofilm Dispersal in Diabetic Mouse Antibiotic Treatment MS1-2 ENDSLEY, AVERY MS1-2 ENDSLEY, School: School of Medicine Hashimoto’s Hashimoto’s disease is an autoimmune thyroiditis and a common cause of hypothyroidism. strong Family familial tendency and to Environmental HT. twin triggers such studies as D Vitamin indicate deficiency maya deficiency promote D autoimmune vitamin with diseaseIndividuals through thyroiditis. Hashimoto’s in result and BACH2/PDCD5-FOXP3 as such pathways deregulated thyroid of presence the of predictor independent an is status D Vitamin Disease. Hashimoto’s having of chance higher much a have Vitamin titers. antibody anti-thyroid with associated inversely are levels D Vitamin disease. the of hallmark a are which antibodies, D deficiency tends to be more commonthyroiditis in patients Hashimoto’s with overt hypothyroidism or subclinical- hypothyroid studies Further antibodies. anti-thyroid reduce can deficiency D Vitamin treating Moreover, individuals. euthyroid to compared ism status hypothyroid subclinical or euthyroid either with patients Thyroiditis Hashimoto’s treating that concluding to prior needed are with D Vitamin will halt progression to overt agree hypothyroidism. We that screening patients with Thyroiditis Hashimoto’s for Vitamin D deficiency and assisting patients deficient Vitamin in D achieve a replete status is a good strategy pending additional studies. Vitamin D deficiency is highly prevalent. Its endocrine effects are well known, the paracrine and autocrine effects have received less received have effects autocrine and paracrine the known, well are effects endocrine Its prevalent. highly is deficiency D Vitamin an D as Vitamin for role emerging An D receptor. vitamin affinity high nuclear a through mediated are actions D Vitamin attention. cells Th1 of activity the reduces D Vitamin evident. is sclerosis Multiple as such diseases autoimmune many in modulator immune which are known to promote inflammatory cytokines. Certain polymorphismsVitamin of D the receptor may increase the genetic autoimmune diathesis. susceptibility to an Blair Elmore, Rainna Coelho, Corresponding Author: Alan N. Peiris MD, PhD N. Peiris MD, Alan Author: Corresponding Rainna Coelho, Blair Elmore, MS1-2 ELMORE, BLAIR ELMORE, MS1-2 D Deficiency and Vitamin Disease Hashimoto’s

ABSTRACTS 62 School: SchoolofMedicine complications were seen. dermoid cyst was 24 g and measured 4.2 x 3 x 3 cm. The sublingual gland was 2 g and measured 3 x 2 x 0.6 cm. No post-operative gland and submental epidermoid cyst. A transoral surgical approach was taken; the cyst and sublingual gland were excised. The epi- mation in the right sublingual gland. A literature review yielded only one other case with co-presentation of an inflamed sublingual synonym for epidermoid cyst. In addition to the epidermoid cyst, the patient also presented with focal chronic non-specific inflam- a region. cyst, submental inclusion the epidermal in an mass showed fluctuating report palpable pathology a post-operative with A comprised of tissue derived from germ layers foreign to their location. This case reports a 13 year old female patient that presented Epidermoid cysts arelesionsveryrarelyseenintheoralcavity. Epidermoid cysts, teratomas, and dermoidcystsareneoplasms Callie L.FortMS,CynthiaM.SchwartzMD, Winslo K.IdiculaMD Epidermoid Cyst: A CaseReport MS1-2 FORT, CALLIE School: SchoolofMedicine These significantdifferencesduetogingersupplementationmaybebeneficialsignsforneuropathicpainrelief. phan, L-Tyrosine, L-Phenylalanine).Furtheranalysisoffecalfunctionaldataisongoing. (L-Trypto- pathway AAAB the L-Valine)and L-Glutamate, 4-Methyl-2-oxopentanoate, (2-Oxoglutarate, pathways BCAAB the in metabolites fecal for SNL control the and SEG) and (GEG groups ginger-supplemented the between observed were differences Significant acidbiosynthesis (p>0.05). groups control SNL the and amino sham the between 3 pathways chain these in observed were differences significant branched 4groups: statistically No (AAAB). biosynthesis acid the amino aromatic among and (AACD), affected degradation compound aromatic pathways anaerobic (BCAAB), metabolic key few a on focused study This ware. soft- discoverer compound and LC-MS/MS using analyzed was phase aqueous The centrifuging. and v/v) (1:2:1 methanol/water dichloromethane/ with sample µL homogenized 100 of combining buffer. by PBS extracted in were beater Metabolites bead using enriched ginger root extract (SEG), starting on the day of SNL surgery and lasting 30 days. 50mg fecal samples were homogenized shogaols- with one and (GEG) extract root ginger gingerols-enriched with one treatments, received Two(SNL). groups SNLtion A cohort of 16 male rats was divided into 4 groups. One group received a sham surgery and the others received a spinal nerve liga extract (GRE)onGMDMinneuropathicpainmodels. root ofginger effects the evaluates study This potential. great poses agent, anti-inflammatory and (Zingiber analgesic an Roscoe), Ginger officinale pain. chronic for strategy therapeutic new a represent may GMDM in changes with intervention dietary Thus, cells. immune of infiltration and microglia of activation the include pathways These (GMDM). mediators microbiota-derived gut through pain chronic of pathways sensitization central and peripheral of modulator key a as microbiota gut indicate studies Recent Chih Yu Fang,SamirSherali,MasoudZabet,XiaoxiaGong,ParvinMirzaei,Rui Wang, Volker Neugebauer, Chwan-LiShen The effectsofginger root extractongutmicrobiota-derived metabolitesinanimalswithneuropathic pain MS1-2 FANG, CHIHYU School: SchoolofMedicine stated compliancewithlevothyroxineonadailybasis. despite procedure sleeve gastric following hypothyroidism significant developed Patient thyroxine. with treated hypothyroidism which can be altered by gastric pH, other drugs, food, and other factors. We present a 35-year old female patient with longstanding weight based and administered at approximately 1.6mcg/kg body weight. Absorption occurs mainly in the jejunum and upper ileum, ing gastric bypass; however, few studies have addressed this issue after gastric sleeve procedures. Levothyroxine dosage is usually Bariatric procedures for weight loss have increased in the past few decades. Levothyroxine malabsorption has been reported follow- Kristen Fain, Alexsandra P. Rojas, Alan N.Peiris,M.D,PhD Hypothyroidism followinggastricsleevesurgery resolved byingestingcrushedthyroxine tablets MS1-2 FAIN, KRISTEN - 63 ABSTRACTS - - MS1-2 FULTON, ALEC MS1-2 FULTON, Year Medical Students Over the Respira on First Videos and Question Banks Learning Observing the Effects of Student Created School: Graduate School of Biomedical Sciences Following data collection and analysis, post-test students’ scores and overall learning experience of those who used one, both, or neither of the resources will be compared to observe the resources effectsFeedback onon the materialquality comprehensionand helpfulness andof the learningresources experience. will be used to assess areas of improvement and the personal students’ satisfaction of the resources. The results will help in determining if supplemental student created learning modules and question SOM courses. banks elicits similar positive feedback as previous student created resources for Feedback on content focus from students previously enrolled in the course was utilized in the creation of the modules and ques- tion banks. Required textbooks, old lectures, and other recommended resources were used as the source content for the modules and questions. Nine respiratory and acid balance questions were administered to students prior to the unit to get a baseline of the knowledge. students’ Following the unit exam, a post-test consisting of the same nine questions was administered. In addition, a survey evaluating the quality and helpfulness of the modules and question banks, as well as overall learning experience during the unit, was taken. Video explanations created by former students Video (learning modules) and question banks with detailed explanations of both right and wrong answers University in Tech School other of Texas Medicine (SOM) courses, such acid as and the respiratory anatomy block the of for the created curriculum, been not have questions and modules type These students. by received well been previously have balance portion of the SOM course, Major Systems Organ (MOS). For this project, student created learning modules and question banks were created and used to observe whether they would improve the overall learning experience for medical students in this portion of the curriculum, as it did in others. School: School of Medicine Alec Fulton tions of the groin and lower limb have been documented secondarily to invasive colorectal cancer (CRC). We present a rare case of case rare a present We (CRC). cancer colorectal invasive to secondarily documented been have limb lower and groin the of tions upper 2-week with presented male 39-year-old A NSTI. of development following years 5 than greater diagnosed cancer colorectal the to taken was and NSTI with diagnosed was patient The cellulitis. and leukocytosis, fever, of symptoms systemic and pain thigh operating room for The debridement. wound was debrided a second time during his hospital stay with a finalwound dimension of controlled, was infection Once Streptococcus. beta-hemolytic and coli Escherichia for positive were cultures Wound cm. 46 x cm 41 he underwent a split thickness skin graft to the right flank, abdomen and lower There thigh. were no indications of colon cancer at the time and he was discharged after a 3-week hospital stay with anticipation to follow-up with the surgery team. Five years later, biopsies and performed was colonoscopy A pain. abdominal colicky diffuse with department emergency the to presented patient the indicated invasive cecal and descending colon adenocarcinoma. He underwent subtotal colectomy with primary ileorectal anasto- a mosis. cecal Intraoperatively, mass was found eroding into the right lower quadrant of the abdominal wall. He was treated post- operatively with several rounds years hospice Two of later chemotherapy. to (seven admitted years after was his and NSTI tube diagnosis) gastrostomy he open developed malignant venting a received he disease, his of severity the to Due obstruction. bowel small in NSTI that suggests presentation case this CRC, pre-existing a with concomitant NSTI of cases documented are there While care. low-risk patient should raise suspicion for CRC in future cases. the groin, flank or thigh in an otherwise Acid Balance Physiology Section tory and Necrotizing Necrotizing soft tissue infections (NSTIs) are highly aggressive and possibly lethal infections if untreated. Polymicrobial infec Caroline Freedle, Jasmin Rahesh, Michelle Harris, Virginia Tran, Sharmila Dissanaike Tran, Virginia Michelle Harris, Jasmin Rahesh, Caroline Freedle, MS1-2 FREEDLE, CAROLINE FREEDLE, MS1-2 after NSTI presenting cancer colorectal case of stage IV rare A

ABSTRACTS 64 School: SchoolofMedicine look intothecareofferedatFreeCliniccanbeusedto reachgoalsinpatientcare. terparts. Consistent access to quality care, education, and resources for hormone therapy are vital for healthy lifestyles. A qualitative Conclusion: At riskpopulationsinclude transgender patients since they aremorepronetocomorbidities than theircisgendercoun- levels, lipid,CBC,andCMP labsand3 month refillsoftestosterone. testosterone include which visits, up follow for seen were others five and therapy masculinizing initiated patients transmen our of and were seen for their 3 month follow up visits with CBC, CMP, TSH, and lipid panel as well as 100 mg clinics spironolactone other at refills.therapy initiated therapy. had feminizing transwomen underwent two two The Two and therapy hormone masculinizing Results: Nine patients were treated for hormone therapy at The Free Clinic from November 2018-November 2019. Seven underwent for voicecounseling,asafephysicianslist,andlistoftransgender affirmingresourcesinthearea. given a demonstration and instruction for hormone injections. They are supervised during their first self-injection and given referrals are obtained, used for baselines, and to guide both permanent tests and transient changes. Patients undergoing Blood therapy. masculinizing therapy are hormone of effects expected the explaining consent informed an through walked are Patients visits. therapy up follow and initiating for plan the including explained be will therapy transgender for procedures our of details The Procedure: continue improvingtheircare. to us allow and receive patients transgender our therapy hormone the into insight provide will procedures the into look qualitative and therapy.in-depth hormone This transgender for Clinic area. Free The at used surrounding guidelines and procedures and the detail will project Lubbock This in population uninsured the to healthcare free provides Clinic Free TTUHSC The Background: Ana Garcia,MS1,MaryMiller, MS4,Dr. FionaPrabhu,Dr. KellyBennett Transgender Healthcare Undergoes Transition MS1-2 GARCIA, ANA School: SchoolofMedicine in presentationandambiguousresultsfromstandardimagingtechniquesmakespontaneousbladderrupturedifficulttodiagnose. foration. Multiple causes of spontaneous bladder rupture are cited in the literature, all with varying presentations. The inconsistency an of finding later and abnormal pelvic UTI mass lead acute to an exploratory an laparotomy.of The misdiagnosis procedure concluded initial with the repair An of pain. an extraperitoneal abdominal bladder per of history two-month a with presenting rupture bladder spontaneous with female 73-year-old a of case Wea condition. describe rare a is rupture bladder idiopathic Spontaneous, Bernardo Galvan,KateHolder, Dr. Allen Medway Idiopathic SpontaneousBladderRupture: A CaseReportandReviewofLiterature MS1-2 GALVAN, BERNARDO - 65 ABSTRACTS - - . gery pathway for this patient population. gery pathway for this urinary tract. These can include infection, pain, hematuria, stricture formation, genito the fistulainto bodies formation,foreign a andof Ainsertion urolithiasis.for studyreasons the of of some the highlight that reviews and reports case various shows literature elucidate to aim We abuse. or intoxication, contraception, perceived illness, psychiatric autoeroticism, includes which tract, urinary the presentation and incidence of these cases in Lubbock County and the surrounding area. Many of these cases presented involve and utensils, blades, razor caps, pen include which system genitourinary lower their into bodies foreign inserted have who patients dominoes. For these cases, TTUHSC the Department of Urology conducted various non-invasive and invasive methods to extract the bladder the foreign bodies from the penis, scrotum, various segments of the urethra, and School: School of Medicine Foreign bodies in the genitourinary tract can pose serious medical problems. These objects, including everyday household items, everyday including These objects, problems. can pose serious medical tract Foreign bodies in the genitourinary can come in various shapes and sizes. Inserted foreign bodies can lead to both acute and chronic problems of the lower genito Asher K. George, MPH (primary), Jaime Camacho, MD Asher K. George, What the Stuck?! Management of Foreign Bodies of the Lower GU Tract: A Review and Case Series A Tract: Bodies of the Lower GU What the Stuck?! Management of Foreign MS1-2 GEORGE, ASHER MS1-2 GEORGE, School: School of Medicine Total thyroidectomy for report hyperthyroidism the Total is unusual usually recurrence We curative. of thyrotoxicosis following a near- total The thyroidectomy. patient, a 27-year-old woman, elected to have a total thyroidectomy and began levothyroxine after the procedure. Approximately 2 years later, recurrent thyrotoxicosis was evident offVascularized levothyroxine. thyroid tissue was antithyroid She began region. thyroid the right in uptake increased scan indicated iodine radioactive and a on ultrasound, noted the implications discuss We a euthyroid state was achieved. once iodine with radioactive and was subsequently treated medication thyroidectomy. after near-total of this rare scenario—recurrence of thyrotoxicosis Paul Gaschen BA, Joehassin Cordero MD, Alan Peiris Md Paul Gaschen BA, Joehassin Cordero MD, MS1-2 GASCHEN, PAUL PAUL MS1-2 GASCHEN, thyroidectomy near-total following thyrotoxicosis Recurrent School: School of Medicine Conclusion: The hypothesis will be confirmed or rejected once data analysis is complete. Conclusion: Results: 349 patients identified as having an appendectomy during the time of Data the extraction study. and statistical analysis is being completed. Methodology: A retrospective chart review of all patients under 18 years of age undergoing laparoscopic appendectomy from 4/1/17 from appendectomy laparoscopic undergoing age of years 18 under patients all of review chart retrospective A Methodology: to 3/31/19 will be performed. Intro: Laparoscopic appendectomy for simple acute appendicitis is an outpatient procedure in many adults. Pediatric surgeons have surgeons Pediatric adults. many in procedure outpatient an is appendicitis acute simple for appendectomy Laparoscopic Intro: been slower to adopt this approach due to concerns about adequate postoperative pain control in a population where postoperative narcotics are generally not used except for severe breakthrough pain. The purpose of this study is to evaluate the current practice postoperative and anesthetic local intraoperative of use the regarding (CCH) Hospital Children’s Covenant at surgeons pediatric of that hypothesize We appendectomy. laparoscopic undergoing appendicitis acute simple with patients pediatric for management pain the addition of a longer acting local anesthetic to the more commonly used short acting local anesthetic will decrease the need for postoperative parenteral pain medications and narcotics in this population facilitating same day discharge. The findings from this after sur develop and study an enhanced recovery study can be used to Omar Garcia Omar Garcia MS1-2 GARCIA, OMAR GARCIA, MS1-2 appendicitis patients with acute in pediatric Pain management

ABSTRACTS 66 School: SchoolofMedicine as itappearstobethenextmost likelycontributortodegreeofvault. Discussion: Further testing must incorporate multiple factors into the study. The next step is to design a setup that can test iris angle, than thediameteralonethatitiscompressedto. Results: Preliminary results show that there are more factors contributing to an ICL’s degree of vault once implanted in a human eye diameter andvaultinactualpatientsataUT surgical clinic,Hoopes Vision. ICLfor values post-surgical against tested statistically was vault of degree and compression. diameter each Abetween correlation at taken photos of analysis software computer by measured then was produced vault of degree The increments. mm 0.1 at range useful its across diameters particular to ICLs compress to micrometer a utilized and vitro in performed was study This Methods: the existingbutlimitedanderror-prone setcurrentlyusedbyeyesurgeons performingthisprocedure. purpose of this study is to analyze the ICL’s mechanic properties and elaborate a new set of sizing recommendations that build upon formation. The cataract accelerated or glaucoma closure angle produce can over-under-vaultingresults consequent or that the and iris sulci into which its ends are tucked. Because of its close proximity to the iris and crystalline lens, incorrect sizing by the surgeon between the irisanteriorly and thecrystalline lens posteriorly, with a central anterior vault created by itscompressionbetween the neas are too thin for conventional corrective procedures such as LASIK or PRK. It is implanted in the posterior chamber of the eye Background: The implantable collamer lens (ICL) is a surgically inserted lens that can correct refractive error in patients whose cor Graham, Derrick;Moshirfar, MajidM.D. Mathematical pilotstudyevaluatingimplantablecollamerlensvaultinvivoandvitro. MS1-2 GRAHAM,DERRICK School: GraduateSchoolofBiomedicalSciences at-risk studentsforearlyacademicintervention. identify and success student predict to also but tool educational supported student a as only not exams practice use to ability the summative shows and exams formative Anatomy the between parallel direct favorable). This 5=extremely unfavorable, extremely (1= 4.28 a was exam practice lab the of perception average the students, the to issued scale Likert however,5-point a to according for unit three and both with p-values <0.0001. Data on the stress levels of students who utilized the formative 0.783 exams r= is pending, and two unit for 0.738 r= an with scores, NBME the to correlated positively exams summative addition, In <0.0001). p-values respectively,with three and two units for 0.70 and 0.66 of values (r exams lab summative and exams lab formative the between correlations positive showed data p-values. the and of values) Analysis (r Coefficient Correlation Pearson using analyzed second and third laboratory practice exams, the second and third summative lab exams, and scores from the NBME final exam were students immediate feedback. To measure the ability of these formative exams to predict exam performance, the averages from the offer to rationales and scoring question provided as well as anatomical models and cadavers of images utilized exam lab formative course. the The during exams unit summative three the of each before students to provided was exam lab practice online an stress, Oriented cally established. well not is Anatomy Toreduce and students at-risk predict can exams formative these whether evaluate However, demandingenvironment. tool. study excellent Clini in wellbeing student overall impact and standing andeducationally academic predict may an exams practice laboratory how of understanding the with fast-paced students provided ina has exams formative of utilization findthemselves the years, pre-clinical students Throughout school, of medical year first the During Megh Gore,Bridget Vories, GurvinderKaur, BrandtSchneider Using FormativeExamsinClinicallyOriented Anatomy: Identifying At-Risk StudentsandReducingStress MS1-2 GORE,MEGH - - 67 ABSTRACTS . School: School of Medicine Maxillary sinusitis is a relatively common condition with 4.1 million physician visits per year dedicated to the treatment of chronic of treatment the to dedicated year per visits physician million 4.1 with condition common relatively a is sinusitis Maxillary maxillary of causes many are There sinusitis.1 acute of treatment the to dedicated year per visits physician million 7.7 and sinusitis sinusitis the vast majority being viral infection with a small subset being bacterial and fungal in origin. S. catarrhalis, Of M. influenzae, the H. bacteria), subset common (most of pneumoniae S. sinusitis are pathogens common most the origin, in bacterial is that with female white 72-year-old a of presentation unusual the on focus to is report case this of objective The pyogenes.2 S. and aureus, past with presented patient The parasanguinis. Streptococcus and micra Parvimonas cultured that sinusitis maxillary unilateral acute medical history of chronic obstructive pulmonary disease (COPD), hypertension, and paroxysmal nocturnal disease (PND) to the ENT clinic at our institution with complaint of right maxillary pressure persistent for months, headache, and rhinorrhea. Physical uncinate bulging a and teeth, maxillary missing rhinoscopy, anterior with sinus maxillary right the of view limited a revealed exam process of the middle meatus with no nasal obstruction, bleeding, polyps, or rhinorrhea. A computed tomography scan revealed unilateral opacification of right maxillary sinus identified as a soft The tissue soft attenuation mass. tissue mass expanded the right maxillary sinus and eroded the right maxillary sinus Three walls. weeks after patient was seen in the clinic ENT endoscopic right- sided maxillary antrostomy with tissue removal was performed and patient was sent home. Since surgery and discharge from the hospital, the patient is doing well with no sinus pressure or At pain. this time, patient has resolved with no evidence of recurrent infection. Our aim is to present this case to update literature regarding maxillary sinusitis, and to increase awareness amongst the otolaryngologist and dental Bailey Harvey B.S., Cynthia Schwartz M.D., Joshua Demke M.D Bailey Harvey B.S., Cynthia Schwartz Case Report: An Unusual Presentation of Unilateral Maxillary Sinusitis that Cultured Parvimonas micra and Streptococcus para- Parvimonas micra and Streptococcus of Unilateral Maxillary Sinusitis that Cultured An Unusual Presentation Case Report: sanguinis MS1-2 HARVEY, BAILEY MS1-2 HARVEY, School: School of Medicine Our aim is to assess the perception that high-risk pregnant women have regarding the severity of their pre-existing co-morbidities. their influence women pregnant high-risk of conditions health pre-existing the how understanding in interested are we particular, In pregnant high-risk for outcomes and care obstetrical the complicate that co-morbidities common The pregnant. become to decision high-risk surveying involves study This disease. renal and obesity, morbid diabetes, disease, heart hypertension, include women pregnant women about their level of awareness of their pre-existing conditions, and the degree that their previous conditions im- pacted their decision to also become aim pregnant. to We understand if these high-risk pregnant women feel that their health-care providers could have better prepared them for the complications of pregnancy given their prior health conditions. we Ultimately, order in pregnancy with arise that challenges the for conditions pre-existing with age reproductive of women prepare better to hope and their health during and after pregnancy decision making around pregnancy to improve their informed Cornelia de Riese, M.D., Frances Kellerman Hanson – TTUHSC SOM Class of 2022, Duke Appiah, PhD, MPH; Participating Re- Participating MPH; PhD, Appiah, Duke 2022, of Class SOM TTUHSC – Hanson Kellerman Frances M.D., Riese, de Cornelia M.D., PhD Schlabritz-Lutsevich, searcher: Natalia MS1-2 HANSON, FRANCES HANSON, MS1-2 and During Pregnancy Before their Personal Health of Perception Women’s High-risk Pregnant Assessing

ABSTRACTS 68 School: SchoolofMedicine retrospective studydidnotnecessitate anyintervention. All study datawillhavebeeninexistencepriortothisstudy. This paralysis). nerve malignancy,facial of reported stage type, histology benign/malignant, mass, parotid of (diameter study this for sheet data a in recorded and collected were following The 07/01/2019. through 01/01/2010 of Cerner dates the from between collected PowerChart was gland parotid the of neoplasm of diagnosis a with patients of review retrospective This METHODS: STUDY DESIGN:Retrospectivechartreview, hypothesis-driven paralysis byreviewingmedicalrecordsofpatientsdiagnosed withparotidneoplasmwhoreceivedaparotidectomy nerve facial and characteristics tumor chosen between correlations are there if identify to is study this of objective primary •The at asingleuniversitymedicalcenterovertimeperiodof nine years. PURPOSE: •The purpose of this study is to identify factors predictive of facial nerve paralysis following parotidectomy conducted paralysis. nerve facial of outcome negative predicting factors establish to goal the bock, with Texas)evaluated were 2019 and 2010 between (Lub- Center Medical University at managed and diagnosed tumors gland parotid with patients from collected study,data this In types of tumors may not require the same parotidectomy techniques to be used, based on the size and the malignancy of the tumor. histology various the practice, clinical in However, paralysis. nerve facial of risk the reduce to made been Varioushave attempts In mostcases,revisionparotidectomymayprovetobemoreharmful. performed. surgery,is initial parotidectomy this revision of defects cosmetic parotidectomy.and functional Tothe for compensate common locations for a salivary gland tumor. However, there is a high risk of facial nerve resection that is associated with primary BACKGROUND: The incumbent procedure to remove any tumor of the parotid gland is a parotidectomy, which is one of the most Mia Ivos,CallieFort,HannahDaniel,Dr. Rahul Varman, Dr. Tam Nguyen Factors Predictive ofNegativeOutcomesFollowingParotidectomy MS1-2 IVOS, MIA School: SchoolofMedicine ate commonalternativesforurinediversion. after birth. ureterosigmoidostomy shortly thepatient’sthe effectivenessof assess will study This evalu ureterosigmoidostomyand a exstrophy,underwent bladder with born patient, The neoplasm. colon sigmoid of indicative scan CT a with clinic in presented study,case 53-year-oldthis male a In treatment. preferred the bladders neoplastic and conduits ileal by treatment made eventually patients ureterosigmoidostomy in rates cancer colon and bladder Higher continence. urinary maintain to looking patients in sion Abstract: The ureterosigmoidostomy, a procedure now deemed antiquated by many, was once the preferred practice of urine diver Kate Holder, BernardoGalvan,Dr. Allen Medway Ureterosigmoidostomy Effectiveness, Alternatives,andOncologicImplications:aCaseStudyLiterature Review MS1-2 HOLDER,KATHERINE . - - 69 ABSTRACTS - genome. While miRNAs have mitochondrial chondrial microRNAs have been shown to modulate the translational activity of the

The purpose of our study is to (18-25 summarize small are recent MicroRNAs disease. findings Huntington’s inand mitochondrial Parkinson’s microRNAs Alzheimer’s, thatincluding demonstratediseases, theirneurodegenerative age-related role in aging and important are They expression. gene of regulators post-transcriptional as act that molecules RNA noncoding length), in nucleotides and differentiation tissue development, embryonic proliferation, cell growth, cell as such processes, biological several of regulators apoptosis. Currently, over 2000 mammalian microRNAs have been reported to regulate biological processes. In 2011, Barrey et mito 400 over literature, published to According mitochondria. human in localized be to found miRNAs of subset a discovered al. Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock Texas Lubbock Sciences Center, University Health Tech Texas Department of Internal Medicine, School: School of Medicine Albin John MD student, Aaron Kubosumi, MD Student, P. Hemachandra Reddy, PhD. Hemachandra Reddy, Aaron Kubosumi, MD Student, P. Albin John MD student, been studied for years, researchers are still scratching the surface when it comes to the function of mitochondrial microRNAs and and roles in aging we briefly discuss known microRNAs and their study, In the current role in aging and disease pathologies. their will also discuss mitochondrial microRNAs and their involvement in regulating the mitochondrial We neurodegenerative diseases. genome in aging and neurodegenerative diseases. MS1-2 JOHN, ALBIN MS1-2 JOHN, Diseases? Aging and Neurodegenerative in Process Key Regulators of Disease MicroRNAs Mitochondrial Are School: School of Medicine Neck dissections have been a consistent treatment option in the management of head and neck cancers, yet they pose very high risks high very pose they yet cancers, neck and head of management the in option treatment consistent a been have dissections Neck infection, bleeding, significant in resulting neck, the in structures vital to damage cause can dissection neck a Performing patients. to Ad- cords. vocal the with problems as well as neck and face the of weakness and numbness to lead could that nerves to damage and when more ditionally, lymph nodes are unnecessarily removed lymphatic drainage is significantly impaired. There is currently an underwhelming amount of data regarding the specific lymph node levels that aremost commonly involved with different subtypes involve recommendations current of majority The grade. and stage their on based spread of pattern the and cancers neck and head of either operating on multiple lymph node levels or a very large area of the neck, such as the entire lateral neck or the entire central neck. If specific patterns of spread exist between a specific type of cancer at different lymph stages which and to identify the to lymph aims node study levels This involved, patient. the to risks fewer pose and efficiently more performed be could dissections neck on performed be will study cohort retrospective A spread. preferentially cancer neck and head of subtypes different that levels node neck after nodes lymph positive contained levels node lymph neck which identify to facility local a at patients cancer neck and head dissections. Factors that will be evaluated include grade and stage of the cancer, site of cancer, location of positive lymph nodes, Based prior to surgery. been initiated have and radiation and whether or not chemotherapy node density in those locations, lymph neck dissections could be made based on the subtype of cancer being treated. recommendations for on the results of this study, Brianna Hope, MS3; Hannah Daniel, MBA; Neil Jain, MS1; Rahu Varman, MD; Tam Nguyen, MD; Joehassin Cordero, MD Nguyen, MD; Joehassin Tam MD; Varman, Jain, MS1; Rahu Daniel, MBA; Neil MS3; Hannah Brianna Hope, MS1-2 JAIN, NEIL JAIN, MS1-2 Head and Neck Cancer Subtypes of Level Patterns in Different Node Neck Lymph Determining

ABSTRACTS 70 School: SchoolofMedicine of bothSMA andzSMA-encasednanodiscs(termedSMALP andzSMALP, respectively). MPs. reconstituted without and Wewith both nanodiscs, synthesis for protocol the optimizing on data preliminary our present will andcontrolthe mechanism theself-assembly tounderstand formation of polymer-encased nanodiscs. An ideal synthesis protocol would yield a homogeneous and monodisperse population of opportunities upunprecedented opens Which, structures. well- with defined polymerization controlled/living by prepared are zSMAs the etc.), ratio stoichiometric S/MApolydispersity, weight, molecular as (such structures poorly-defined their for known are and coatings, or dispersants, binders, industry as developed nally origi- were which SMAs, commercial Unlike polymer-encasednanodiscs. of behaviors formation the elucidate to aims study This amide (zSMA)copolymersthatovercomethebufferincompatibility ofSMAs,havingimprovedstabilityinawiderpHrange.^2 form nanodiscs, but have the issue of buffer incompatibility.^1 For this reason, the Liang lab developed zwitterionic styrene-maleic which bypassthedetergentmaleic acid copolymers(SMAs), solubilization process bydirectly cutting intonativemembranesto styrene- with proteins scaffold the replace nanodiscs, encased Polymer denaturation. risks process solubilization this but branes, from human apolipoprotein A-I. In order to prepare the MP-supporting nanodiscs, MPs have to be released from their native mem lipid nanodisc is composed of a small discoidal lipid-bilayer patch encased within two belt-like membrane scaffold proteins derived platforms. MP-supporting promising most the of traditional one A represent nanodiscs Lipid platforms. membrane well-defined in MPs supporting and isolating stably in difficulty the to due challenging, yet crucial, is MPs of function and structure the standing Under market. the in pharmaceuticals of ~70% of targets the and genome our of ~30% by coded are (MPs) proteins Membrane Elizabeth Kamilar, Wan Zheng,PhD.,HongjunLiang,PhD Nanodisc Characterization MS1-2 KAMILAR,ELIZABETH School: GraduateSchoolofBiomedicalSciences to improvetheseinteractivemodules,andalsoexpandthisprojectcoverallhistologicaltissuesinthefuture. necessary be will feedback More exam. histology their for preparation in students for tool study helpful a was modules interactive Overall, the results show a positive impact for those that utilized the modules. During this trial, it was shown that the blood histology One month after the modules were given to the students, a survey was sent comprehension. to those their that test used and to those questions that did practice not use answer the as modules. well as images, histological blood various view to students the allowed modules The curriculum. first-year the in exam Tissuesand histology Cells of Biology the for preparation in material the learning after immediately students medical the to available made was resource This lineages. their and cells blood major the of acteristics char functional and structural describing histology blood over created was module online interactive an Captivate, Using Adobe the Texasat implemented been not has Techsystem Center.module however,Sciences complete histology; Health a in University this establishing in tool great a be to shown been have modules learning Interactive (pathology,pharmacology,physiology,etc.). sciences medical of disciplines other with material the integrate properly to order in foundation this have to students for important is It education. medical basic of understanding the in foundation major a been has students medical for histology basic Learning Daemar Jones,Dr. Dan Webster Implementing InteractiveLearningBasedModulestoEnhancePatternRecognitioninHistology MS1-2 JONES, DAEMAR - - - 71 ABSTRACTS - - - - gery, gery, gitation. The most com gitation. gitation. The regurgitation can also lead to severe The regurgitation gitation. The patient underwent mitral valve replacement, and The patient underwent School: School of Medicine Scientists have long characterized and documented the roles of subcortical central nervous system (CNS) regions in stereotyped activities, such as posturing and there locomotion. was However, a lack of understanding of the role of cortical CNS regions, spe- cifically the motor cortex (MC) and primary motor cortex (M1), in these stereotyped activities. The well-established complexity of neurophysical control exerted via cortical efferent innervation on motor and physiological processes reasonably supports an in- on contingent reviewed, were studies analytical Quantitatively activities. stereotyped in M1 and MC the of role the into vestigation recency of publication (< 5 years) and perceived novelty and importance of findings (well-supported, previously undocumented findings). This review elucidated many clinically significant findings: 1) There is significant activation of the MC and M1 during stereotyped activities such as locomotion, as well as efferent information flow The 2) that indicates cortico-muscular connectivity. activation of specific muscle groups corresponds to specific activation in the M1. Outputs of the M1 carried by cortical efferents and both are outputs excitatory were or mapped inhibitory, and represented in M1 output maps. 3) Bilateral M1 cortices engage in interhemispheric communication through the corpus callosum during a unilateral movement task. Ipsilaterally, output facilitates bilateral contraction of trunk axial muscles. Contralaterally, interhemispheric interaction is inhibitory and functions to modulate trunk contraction. 4) Cortical plasticity drives greater MC activation symmetry in ambidextrous pianists, indicating that practice can induce MC cortical plasticity that enhances fine motor These control. findings support the conclusion that the MC and M1 are involved in stereotyped movements, contrary to the this Moreover, traditional control view. is interhemispheric, responds to feed- back mechanisms, and can be plastically modulated. Abdurrahman Fayez Kharbat; Mimi Zumwalt, MD Abdurrahman Fayez Kharbat; Mimi Zumwalt, Motor Cortex Control of Posture Motor Cortex Control MS1-2 KHARBAT, ABDURRAHMAN MS1-2 KHARBAT, Case: A 61-year-old male presented with shortness of breath on exertion, orthopnea, and leg swelling. The patient was found to be The leg swelling. of breath on exertion, orthopnea, and male presented with shortness 61-year-old A Case: rate control. Other cardiac his with continued symptoms despite with rapid ventricular response on admission in atrial fibrillation from imaging. Perforation was confirmed due to results Decision-Making: well described as a cause of mitral regur Conclusion: Mitral valve perforation is School: School of Medicine mon cause for mitral valve perforation is infective endocarditis, but connective tissue disease, trauma to the chest, cardiac sur trauma to the connective tissue disease, endocarditis, but is infective for mitral valve perforation mon cause causes. are other potential regurgitation and eccentric aortic wall, no history of connective Patient denied any trauma to the chest systolic heart failure and hypertension. tory includes chronic which was confirmed by and mitral valve perforation, regurgitation TTE revealed mitral cardiac surgery. tissue disease or prior anterior leaflet, suggesting jets with one jet going through the examination revealed two mitral regurgitation color doppler A TEE. perforation. but this patient perforations are caused by infective endocarditis, This case was unique as most valve was successful. the surgery tissue disease, or prior The patient had no trauma to the chest wall, history of connective did not present with fever or infection. and subsequent pathology failed to reveal infective endo Urine analysis and blood cultures both were negative, cardiac surgery. carditis as the cause. is left atrial dilatation and The sequalae of chronic mitral regurgitation above. systolic heart failure such as the case described treating the underlying cause of the repair and is surgical The treatment for mitral valve perforation can lead to atrial fibrillation. that early identification and treatment of spontaneous This case highlights endocarditis. perforation, which is commonly infective to signifi the progression of the disease to systolic heart failure, which can lead mitral valve perforation is crucial in preventing cant morbidity and mortality. Background: Mitral valve perforation is a rare and potentially fatal heart condition that causes mitral regur condition that potentially fatal heart is a rare and Mitral valve perforation Background: Cimron Kashyap, MBA, Marina Iskandar, MD, Pooja Sethi, MD MD, Pooja Iskandar, MBA, Marina Cimron Kashyap, MS1-2 KASHYAP, CIMRON KASHYAP, MS1-2 mitral valve perforation case of spontaneous rare A

ABSTRACTS 72 School: SchoolofMedicine or spirituality/religiosity couldbe utilizedtohelppredictresponseantidepressantsand/or anxiolytics. living, engaged loneliness, resilience, if inform can project this of Results loneliness. decreasing while spirituality/religiosity and living, engaged resilience, increase can antidepressants that hypothesize also They disorders. anxiety and/or depressive with and spirituality and diagnosed patients in rates relapse living, lower and response treatment better with associated are loneliness of engaged scores pretreatment lower resilience, of scores pretreatment higher that hypothesize Researchers Results/Discussion: post treatmentscorechangesinresilience,loneliness,engaged living,andspirituality/religiosityscaleswillbemonitoredaswell. rates between patients with high scores on the positive psychology scales will be compared to those who had lower scores. The relapse and anxiety.Improvement for (GAD-7) item 7 Disorder Generalized Anxiety and symptoms depressive for (PHQ-9) item 9 Questionnaire Health Patient by measured be will symptoms Severity relapse. for monitor to months 24 and 12 at and response for monitor to 12 and 8 weeks evaluation, visit first the during measured be will anxiety score and depression any of severity monitor The changes. to 12 week and evaluation first to prior orientation during administered be will measures respectively.These Scale (CD-RISC 10 item scale), De Jong Gierveld 6 item scale, Duke University Religious index scale, and Engaged Living Scale, tive psychology traits (resilience, loneliness, religiousness, and engaged living) will be determined by Connor-Davidson Resilience Posi- disorders. anxiety and/or depressive of diagnosis new with patients 200 include to Methods: aims study prospective a is This predictors oftreatmentresponseinpatientswithdepressionand/oranxiety Objectives: This study aims to examine four positive psychology traits (resilience, loneliness, religiousness, and engaged living) as Nimra Pasha,Samuel Yang ,JanineKlar, Ashish Sarangi,MD,Regina Baronia, MD,ChuckGiles,PhD, Yasin Ibrahim,MD orders? Dis- Anxiety Generalized DepressiveTraitsand/or Major Psychological Predictwith TreatmentPositive Patients Do in Response MS1-2 KLAR,JANINE School: SchoolofMedicine myosis. comorbidities relating to metabolic syndrome inordertobetterunderstandtheassociationbetweenmetabolic syndrome andadeno- for medication taking are who patients exclude to performed being currently is analysis adenomyosis. Additional of development the on diabetes and/or hyperlipidemia, hypertension, treat to used medications of impact study,the the and of nature retrospective differences between the two groups among the other markerssignificant of metabolic syndrome. Limitationsstatistically to this study include sampleshow size, not did data Our (60%). group CON the to compared pregnant previously been have to likely more being (85.9%) the group with AM difference, significant statistically a as presented also pregnancy Prior group. CON the in those was a statistically significant difference in weight between the two groups, with the AM group having a BMI 3.62kg/m2 higher than there that showed analysis This performed. was groups, (AM) adenomyosis and (CON) control the of each in patients 100 charts, patient 200 of analysis data Preliminary profile. lipid serum and HbA1c, BMI, weight, as such syndrome metabolic of suggestive We performed a retrospective electronic chart review of pelvic ultrasounds and electronic clinical charts to extract surrogate markers OB/GYN, MBA, PhD, M.D., Rohali Keesari,Ph.D. Riese, de Cornelia MS4, MacLeay, Katie MS2, Kishan, Raina MS2, Hanson, Kellerman Frances Investigating the Association betweenMetabolicSyndrome and Adenomyosis MS1-2 KISHAN, RAINA . 73 ABSTRACTS - - - gets in need of further research. tion from intestinal contents, each of which are also associated with oncogenesis. it Importantly, has been demonstrated time and dysregulation said of profile exact the and metabolism, sphingolipid of dysregulation display tumors different many that again time chemotherapeutic various to susceptibility the also but tumor, a of presence the only not determining in useful be to proven been has drugs, the metastasizing characteristics of the malignancies, and the efficacy of Since chemotherapy. these discoveries surfaced it has become apparent that the understanding of sphingolipid metabolism and profile will likely become of great importance in the clinic for both chemotherapy and diagnostics of The cancer goal respectively. of this paper is to provide a comprehensive review Additionally, trials. clinical undergoing are that metabolism sphingolipid target that agents chemotherapeutic of state current the of tar we will formulate questions involving the use of sphingolipid metabolism as chemotherapeutic School: School of Medicine Emerging studies in the enigmatic area of area studies in the enigmatic exciting new bioactive lipids have made many discoveries in recent years. Once thought Emerging perform metabolites their and sphingolipids that determined been since has it function, cellular in role structural strictly a play be to for signaling, cellular in role their is importance utmost Of believed. previously was what beyond functions cellular of variety vast a death and cell roles in both cancer play critical that molecules sphingolipids serve as bioactive select it is now well understood that protec intrinsic and pathogens, intestinal from protection inflammation, chronic as such responses cellular other as well as survival, Alexander Kroll, Hwang Eui Cho, Min H. Kang Alexander Kroll, Hwang Eui Cho, Min MS1-2 KROLL, ALEXANDER MS1-2 KROLL, Sphingolipid Pathways Agents Targeting Antineoplastic School: School of Medicine toma have been documented, including progressive epidural hematoma (PEDH). Since PEDH patients are likely to exhibit elevated exhibit to likely are patients PEDH Since (PEDH). hematoma epidural progressive including documented, been have toma cases, acute in seen sequelae fatal potentially the prevent to removal hematoma for craniectomy require to and pressure intracranial a reliable predictor of hematoma growth would be useful to guide early and appropriate intervention. Several markers have been found to be associated with hematoma expansion in intracerebral hemorrhage (ICH) patients, including the CT blend, swirl, and spot This sign. study aimed to assess these markers, along with some not yet supported by the current literature. Presence of intra skull the of involvement as well as fracture, significant a to close and/or hematoma epidural an of region the in or to close air dural hematomas epidural with patients pediatric from Scans growth. hematoma epidural to associations possible for evaluated were base from 2012-2019 were examined and used to determine whether these additional factors are of predictive valuable. Upon review, an association was found between patients whose scans CT showed evidence of the Blend, Spot, and Swirl Signs, as well as those helpful be could markers these of addition The base. skull the of involvement and fraction and/or lesion the of region the in air with in predicting the growth potential of pediatric epidural hematomas, leading to more effective case management and prevention of adverse outcomes. Using signs CT to determine whether intervention surgical should be earlier undergone can be beneficial to the cerebral damage. patient and potentially avoid extensive Epidural hematoma, most often caused by rupture of the middle meningeal artery secondary to head trauma with fracture of temporal the bone, is a fatal condition that can lead to elevated intracranial pressure, herniation, and death within hours following the inciting traumatic incident, unless surgical evacuation is accomplished. However, subacute and chronic forms of epidural hema Avery Kopacz, BS, Hunter Miears, BS, TuongVy Dang MD, and Laszlo Nagy MD MD, and Laszlo Nagy Dang TuongVy Miears, BS, Kopacz, BS, Hunter Avery MS1-2 KOPACZ, AVERY KOPACZ, MS1-2 Growth Hematoma Early Epidural in Predicting Tomography (CT) on Computed of Imaging Markers Effectiveness

ABSTRACTS 74 School: School ofMedicine complications likeCEVDon mortality. septicemia and CEVD. We recommend careful evaluation of LVAD patients with septicemia since LVADit among exacerbates both mortality the had in-hospital impact who of of patients risk other high substantially a observed study,we this In CONCLUSION: among patientswithbothsepticemia andCEVD(RR=3.76,CI:2.38-5.94,Pinteraction = <0.001) (RR=2.84, CI:2.24-3.60); two-and-half fold higher among patients with CEVD alone (RR=2.53, CI:1.85-3.48); and alone almost fourfold septicemia with patients among higher threefold almost was mortality in-hospital of risk the conditions, comorbid and tors patients had septicemia; 8% had CEVD and 2.5% had both conditions. In models adjusted for demographic, lifestyle/behavior fac- women. being of 23% 15% and Approximately years, 56 RESULTS:being age average the with hospitalizations 4659 were There by CEVD-septicemiastatus. mortality in-hospital for (CI) intervals confidence 95% and (RR) ratios risk estimate to used were models linear generalized chical LVADa hierar of Multivariable implantation codes. underwent Revision, 9th Disease, of Classification International of means by METHODS: We used data from the National Inpatient Sample from 2004 to 2015 to identify patients 18 years of age or older who in-hospital mortalityinpatientswithLVAD. with septicemia and CEVD of association joint the investigate to was study this of aim limited. The are survival on complications cerebrovascular as such diseases (CEVD) procedure and septicemia. this However, from large-scale contemporary complications data from many the United are States evaluating cardiovascular There the interaction failure. of with these heart end-stage assist with that patients for devices circulation mechanical implanted (LVADs) are devices assist ventricular Left INTRODUCTION: Jessica Lovelace;NoahDeLaCruz;DamilolaO.OwoadeMPH;NandiniNair Assist DevicesinTheUnitedStates The Joint Association of Septicemia and Cerebrovascular Disease with In-Hospital Mortality Among Patients with Left Ventricular MS1-2 LOVELACE, JESSICA School: SchoolofMedicine of elaborate,highlybranchedamyloidmatricessimilartothoseseeninvivo. the rigidification of the flexible loop into a β-strand may be a mechanism to regulate CRES amyloid assembly, including the building trices in WT, but not LM. On gross examination, LM samples gained precipitate, while WT remained clear. These data suggest that ma- amyloid Further,branched nm. revealed 2000 TEM to nm 100 of assemblies amyloid order higher to transitioned rapidly LM contrast, In weeks. 12 over stable remained that diameter) nm (6 oligomer and an scattering) TEM. to WTassembled immediately light (dynamic DLS by assembly amyloid its followed and (LM) loop mutated a with CRES produced we this, Totest amyloids. guides a novel process of amyloid assembly in addition to the traditional domain swapping that is generally associated with cystatin interaction Wethis B. hypothesize molecule CRES of 5 β-strand with interaction β-sheet pseudo a forming molecule A, CRES in loop flexible a between interaction state. novel amyloid a to showed monomeric Acrystal its resolution from Å spematogenic) 1.9 solution and solid state NMR to follow the assembly of the functional amyloidogenic precursor CRES (cystatin-related epididymal and crystallography X-ray treatment. used for We targeted be can that mechanisms define to hope we disassemble, and assemble able on EM from functional amyloid forms. By elucidating at the atomic level the pathway by which a functional amyloid can both indistinguish are disease in implicated structures amyloid the things, complicating Further amyloids. functional pathogenic, non shows amyloidsplay physiological roles inprocessesasdiverse as spermmaturation and longterm memory, comprising a classof evidence However,growing disease. cause to propensity their for medicine in known are structures, rich cross-β-sheet Amyloids, Cornwall Gail A. Sutton, Bryan Wiley,R. J. Benjamin P.Latham, Michael Dominguez, Matthew Myers, Caitlyn AvelineHewetson, Kusko, E. R. A NovelMechanismof Assembly intheFunctionalCRES Amyloid MS1-2 KUSKO, REBECCA , MDPhD;Duke Appiah PhDMPH - - 75 ABSTRACTS , ED&C) in the 2-year time period. ed Patients at The Free Clinic at The Free ed Patients , we analyzed smokers and found the following: 2.Total lesion length is positively correlated with Rutherford score, particularly among smokers 2.Total 1.Smoking status had the greatest contribution to total lesion length of all co-morbidities. Results: Initially as an example of quality control checkup of registry Methods: For the purpose of the quality control initiative, data collection will be done retrospectively in multiple fields regarding Methods: For the purpose of the quality control initiative, data collection will demographics, presence comorbidities, The fields analyzed will be the patient’s PAD treatment. de-identified patients receiving site location, vessel lesion location, balloon and of symptoms, ulcers, gangrene, Rutherford classification, ultrasound use, access device used, type of crosser that was used, what stent type, length and diameter of the stent or balloon used, type of atherectomy will include a 12, 24 and 36 month follow was used for access site closure, pt presentation, and pt outcomes. Outcome measures infarction, stroke, and death. Inclusion criteria up concerning management of disease and incidence of amputation, myocardial procedures done from January 1st, 2013 to December 31st, 2017. Exclusion and CLI patients ages 18 to 89 with cath lab are PAD criteria is any patient that does not meet the inclusion criteria. Introduction: Peripheral artery disease (PAD) is a prevalent and underdiagnosed disease. The etiology of this disease consists of The etiology underdiagnosed disease. is a prevalent and Introduction: Peripheral artery disease (PAD) ne- ischemic to claudication mild from ranging symptoms many cause can and extremities of the vasculature the in atherosclerosis is an important area of research in cardiology as there is relatively little of PAD The study crosis and subsequent limb amputation. region. In Texas West are only two known registries, but no registries in the There treatment. information on the outcomes of PAD Therefore, due to high incidence of risk factors like DM, HTN, HLD, CAD, and smoking hx. the disease is common Texas West a quality initiative. registry, the focus of this project is to compile the Lonestar PAD School: School of Medicine M.D., Iskandir Marina MS, Brock Randall Joshua M.D., Ajmal Rasikh Investigators: Additional MD, Ansari, Mac Mohammad - PI MS2 Thompson Bray Helton MS3, Baseer Quraishi MS2, Christopher Tyler Cameron David Ludwig MS2, Dermatology Nights at The Free Clinic offer specialized services that uninsured patients maywhich are key notin detecting and treating otherwiseskin conditions that alter bethe quality of their ablelives. These nights emphasize the to importance receive, of screening in order to prevent the occurrence of The future cost-analysis malignancies. provides budget insight for future patient for future funding opportunities. compliance and allows the clinic to apply and Outcomes Diagnosis, Treatment for PAD-CLI Arterial Disease Registry Lone Star Peripheral MS1-2 LUDWIG, CAMERON MS1-2 LUDWIG, We are currently in the process of data analysis for this study. Our early review of data shows 135 patients seen, >30 skin cancers skin >30 seen, patients 135 shows data of review early Our study. this for analysis data of process the in currently are We (e.g. biopsies, excisions, cryotherapy diagnosed, and >65 procedures performed 2.Performing a procedural cost analysis regarding the dermatologic-specific procedural services rendered on Dermatology Nights regarding the dermatologic-specific procedural services rendered on Dermatology 2.Performing a procedural cost analysis 1.Identifying the frequency of dermatologic-specific diagnoses, procedures, and treatments provided to patients on Dermatology Nights The purpose of this study is to conduct a retrospective chart review from February 2018 through February 2020 at The Free Clinic. Free The at 2020 February through 2018 February from review chart retrospective a conduct to is study this of purpose The follows: The objectives are as The Free Clinic at Lubbock Impact, “Dermatology a specialized and focused student-run highly a month, health a Once area. clinic associated Texas with West TTUHSC, surrounding the provides and Lubbock of free city the in healthcare patients to uninsured Night” is held to ensure that those with various skin conditions or malignancies can be treated efficiently and These thoroughly. nights emphasize the importance of skin care management and demonstrate the significance of providing healthcare measures to or have access to them. those unable to afford Sydney Loy, MS, Christine P. Lin, BA, David Boothe, MD, Fiona Prabhu, MD, Kelly Bennett MD, Ashley Sturgeon, MD, Michelle Michelle MD, Sturgeon, Ashley MD, Bennett Kelly MD, Prabhu, Fiona MD, Boothe, David BA, Lin, P. Christine MS, Loy, Sydney MD Tarbox, MS1-2 LOY, SYDNEY LOY, MS1-2 Uninsur Nights for of Dermatology Evaluation and Cost-Analysis An Overall

ABSTRACTS 76 School: SchoolofMedicine ing &evaluation; and6)pilotamodelthatcan beexpanded. week’s content & diagnoses; 4) use physician & scientist faculty expertise to guide discussions; 5) engage students directly in teach the with CAM integrate to students challenge 3) school; medical in well taught not often are which therapies, CAM/IM address 2) course; ongoing an into activity learning self-directed a embed 1) to opportunity the offered project This Conclusions: post-test. faculty scored 67.4% while correct. correct, All groups 70.8% reported higher levels of score comfort and confidence withstudents CAM/IM therapies fromquestions, pre-test to student-submitted On students). for (39% overall correct 41.7% were scores test, post- the on students); for (35.3% overall correct 40% were pre-test the on scores therapies, CAM with conditions health matched that questions of series a On Results: therapies. medicine integrative about attitudes and knowledge of assessments post-course and pre- in participated students and to faculty Both apply information. of synthesis that and thinking competencies critical demonstrate and clinical content, course demonstrating therapies; integrative to content clinical and sciences basic applying include activity this for objectives Learning etc. issues, safety differences, sex- MOA, interactions, drug indications, noting supplement, peers about evidence-based CAM/IM therapies. Each student gave a brief presentation for 2 IM therapies, including one nutritional their educating and researching for responsible were students week, each of topic the on Focusing care. primary in therapies (IM) Methods: FMAT teaching. students studied evidence related to the use of complementary and alternative medicine (CAM) and/or integrative medicine student medical in innovation an assesses and implements develops, that project a on together work faculty Purpose: The TTUHSC FMAT1 course focuses on the top 24 diagnoses in primary care. During each summer session, students and Lursema, NorikoMeridaMorales, Annalee Molina,StephanieRodriguez,Zachary Wilkinson, Matthew Young Integrative for Center TTUHSC PhD, Shen, Leslie Medicine, Medicine , Family FMATof Students, Class of Department 2021: Edward MBA, Alston, Kayden Barber,DO Joshua Brock, Cook, Cheryl Haston, Frankiana Lormeus, Ron Nica EdD, Jones Betsy A Student-Generated,Peer-Led Teaching Activity forIntegrativeMedicineinaFamily Accelerated Track MS1-2 MERIDA-MORALES, NORIKO School: GraduateSchoolofBiomedicalSciences country inpreparingtheirstudentsforembryologyonbothin-houseandboardexams. the across schools medical other for helpful be might model similar a adapting students, the amongst were materials these popular in form of active learning improved student’s grasp of the material thereby augmenting their performance on NBME. Based on how material embryology providing that suggests Collectively,data class. year’sour last to compared improved was NBME on mance perfor their different, significantly not was exams in-house on performance class current the improved. Although, was post-quiz student’s perception of the active learning was favorable. Indicative of better understanding of the material, student performance on post-quiz data were also collected to evaluate the usefulness of an embryology review session before the NBME final exam. Overall, year’s and last to Pre score class. their comparing by embryology to regard with scores exam final (NBME) Examiners Medical of Board National and in-house on performance class current improved learning active whether evaluated and material embryology problems and solutions) will improve student understanding of the material. To achieve this goal, we focused on Unit 3 of the COA bryology fact sheet) to active learning (by incorporating active learning materials such as flash cards, review sessions, and practice em- yield high (reading learning embryology passive converting that Wehypothesize online. provided was topics, key covering cally, embryology has been a difficult topic for students to grasp. To decrease student work load, a high yield embryology fact sheet, Clinically Oriented Anatomy (COA). During this course, the students learn about human anatomy along with embryology. Histori- First year medical students at the Texas Tech University Health Sciences Center (TTUHSC) start their year with a 10-week block of Parker McCabe,Dr. BrandtSchneider, Dr. GurvinderKaur cal Students Incorporating Active Learning MaterialsIntotheGastrointestinal and Reproductive Embryology CurriculumforFirst-Year Medi- MS1-2 MCCABE,PARKER School: SchoolofMedicine as registryresearch. process, arevisedProtocolwillbesubmittedtotheIRBwhichformallyaddressesproceduresnecessaryoperatestudy plans aretoallowotherresearchersaccessthedatacollectedbyinvestigators;however ment modalities,bettermetrics,andmorethoroughguidelinesforaddressingP Conc

AD patientsin West Texas. Additionally, future , priortotheimplementationofthis - - - 77 ABSTRACTS - gical cases (p=0.0024). School: School of Medicine This case illustrates the use of Curve innovative to Sheath technology, facilitate Technique, the challenging Aortic case 3 of Type Arch Right ICA stenosis. Utilizing the Curve Sheath Technique prevented the the patient in integral are technologies new from and innovation how of example undergoing glaring a is Carotid This patient. specific this endarterectomy, for risks mitigating hence development of medical treatment. A A 87-year old patient initially presented to 70% showed angiogram carotid the and made, was stenosis Cardiology ICA clinic of diagnosis clinical for A elective carotid HF. systolic chronic HTN, intervention. CKD, stroke, frontal Patient had a was patient history the Hence, of age. and right co-morbidities to due endarterectomy for risk high at was patient Moreover, ICA. Right of occlusion scheduled for internal carotid artery stenting 3 in the aortic the patient arch, Cath had >2 Lab. Type a diameter Interestingly, of Curve purpose, this For angle. sharp the to due stenosis the to catheter the get to difficult it making (CCA), artery Carotid Common Medtronic self- was implemented, and Cook 90 cm Shuttle Sheath was positioned in the right CCA. Eventually, Technique Sheath developed patient Post-operatively, results. excellent revealed Angiography ICA. in lesion of site the at placed was stent expanding bradycardia without hypotension transiently requiring chronotropic transport The with reflexivedopamine bradycardiainfusion. is stenting. a well described post-procedural phenomenon following ICA larly difficult case of Type 3 Aortic Arch – Right ICA stenosis. Arch – Right ICA 3 Aortic Type larly difficult case of Carotid Artery Angioplasty with Stenting, a minimal invasive procedure, has now become a widely used procedure for carotid artery carotid for procedure used widely a become now has procedure, invasive minimal a Stenting, with Angioplasty Artery Carotid occlusive disease, especially in patients with symptomatic high-risk patients Traditionally, carotid with endarterectomy. >60% particu a present we report, this Within care. standard as endarterectomy carotid underwent stenosis (ICA) Artery Carotid Internal Nitish Mittal; Dr. Mohammad Ansari, MD Mohammad Nitish Mittal; Dr. Utilization of Curve Sheath Technique to Facilitate Difficult Internal Carotid Artery Occlusions Difficult Internal Carotid to Facilitate Utilization of Curve Sheath Technique MS1-2 MITTAL, NITISH MS1-2 MITTAL, Results: Women were observed to have Results: Women chronic injuries more often than men (61.2% vs. 54.1%) a difference thatwas statistically recovery time in sur df=1, p=0.043). Men required longer significant (χ2=4.08, School: School of Medicine Methods: We analyzed 798 Methods: We charts with chief complaints of shoulder or knee pain categorized from patients 2007-2015. We based on then acute looked or at chronic time injury, from referral to first orthopedic appointment, delay and to time the time of surgery, of recovery. Conclusions: Our study shows gender disparity in healthcare between men and women. Data from broader geographic locations is important topic to eliminate bias. essential to educate physicians about this Background: Previous studies have demonstrated that females have more severe pain in more locations on the body than males, but males, than body the on locations more in pain severe more have females that demonstrated have studies Previous Background: unconscious an have may physicians/surgeons Also, outcomes. postoperative worse to leads which help seek to longer wait to tend more for men than women. surgery bias in recommending Amanda Weaver, Katerina Kellar, William H. Miears, Rhett Butler, Ali Ashraf MD, Adam Woolridge MD, Anudeep Dasaraju, Anudeep Dasaraju, MD, Woolridge Adam Ashraf MD, Ali Rhett Butler, H. Miears, William Katerina Kellar, Weaver, Amanda MD. and Mimi Zumwalt Watkins, MD, Phillip Brindley MD, George Matthew Ferguson John Chappa, MS1-2 MIEARS, WILLIAM MIEARS, MS1-2 Knee Conditions for Shoulder and Procedures from Time of Recovery Plus in Seeking Healthcare Ethnic Differences Gender and

ABSTRACTS 78 School: School ofMedicine narrow thediagnosis. This case emphasizes the importance of focusing on the differential diagnosis of small bowel obstruction and the use of imaging to Conclusion: Gallstone Ileus is a rare and infrequent condition typically presenting in elderly females with a history of cholecystitis. ary to a gallstone ileus. No post operative complications were noted and the patient was safely discharged on November 22nd, 2018. mation. Next day exploratory laparotomy, enterolithotomy, and enterorrhaphy was performed for a small bowel obstruction second- the presence of a cholecystoduodenal fistula. Ultrasound revealed thickened gallbladder walls with pericholecystic fluid and inflam- 2018. The patient described the pain as intermittent, confined to the umbilicus area, and prevalent with meals. Radiographs revealed Results: Patient presented to the emergency center with a 1-day history of abdominal pain, nausea, and vomiting on November 18th, November 18th,2018toDecember5th,2018. in November of 2018. Data was collected from an emergency room visit, surgical procedure encounter, and follow ups dating from laparotomy exploratory underwent who obstruction bowel small of suspected female old 74-year a Methods: Weof case a present review ofmechanismssmallbowelobstruction. literature thorough a provide and ileus, gallstone of that obstruction, bowel small Objective: Tofor mechanism unusual an present fistula. Surgical treatmenttorelievethemechanicalsmallbowelobstructionremainsmosteffectivetreatment. not does ileus Gallstone cholecystitis. or cholelithiasis typically present with any defining or unique characteristics; thus diagnostic imaging is key to discovering the cholecystoduodenal of history a with individuals in observed is condition this Often, lation. popu- elderly the in disproportionately seen obstruction bowel small of cause infrequent and rare a is ileus Gallstone Introduction: Kristen FainMS2,M. Warren DO,Babak Abbassi MD, Yana PuckettMD,CatherineRonaghanFAC Mechanical SmallBowelObstructionSecondarytoGallstoneIleus MS1-2 NEIGHBORS, LEXI School: GraduateSchoolofBiomedicalSciences to bettereducatefutureMS1’s. a deficiency in TTUHSC COA curriculum. Students also provided comments that will enable us to refurbish our teaching materials resolving toward step first good a is project our that believe to us lead presentation PowerPoint and videos, prelab the on feedback Student onLikert perineum. the of Based understanding their enhancing at effective favorably. was presentation the modules that stated respondents these of survey,100% rated students improved, significantly not was performance exam Although, exams. board and in-house class year’s last to performance class year’s this comparing by determined was modules these of effectiveness These modules are self-paced with the option to start and stop in the event of interruptions and were made available to MS1’s. The injuries. perineal of students’understanding enhance to textbook course the and lecture from information integrated which tation achieve this goal, we created two modules – 1) prelab videos exposing students to perineal dissections and 2) a PowerPoint presen- Toexams. board and in-house on performance student augmenting thereby topic this of understanding better in result will videos videos to enhance their understanding of perineum anatomy. Based on this information, we hypothesize that male and female prelab perineum structures. Through personal interaction and end of the block reviews, students reported that there is need for these prelab female and male the to students introduce that videos prelab lacks However,TTUHSC’sCOAcurriculum dissections. cadaver to students introduce to critical are guide, dissection step-by-step providing videos, COAPre-lab the block. in dissections laboratory sity Health Sciences Center (TTUHSC), MS1’s begin their medical training by learning about human anatomy through lectures and Clinically Oriented Anatomy (COA) is a core and introductory subject for first year medical students (MS1). At Texas Tech Univer Center, Lubbock, TX. 1Graduate MedicalSciences,2DepartmentofEducation,SchoolMedicine, Tijani Mohammed(^1),BS,andGurvinder Kaur(^2),PhD. Creation ofMaleandFemalePerineumDissectionVideos toEnhanceStudentUnderstandingofPerinealInjuries MS1-2 MOHAMMED, TIJANI Texas Tech UniversityHealthSciences - 79 ABSTRACTS ------School: School of Medicine cally effective dose of non-opioid pain medications among insured adults newly diagnosed with diabetic peripheral neuropathic pain. Prior studies have identified racial and ethnic disparities in pain treatmentdepartments. hypothesized We usingthat race opioids,and ethnicity particularly would inbe associated emergencywith DPN room pain treatment. Our study sample included outcomes treatment investigated that trial controlled randomized negative a Study, Telephone Diabetes the in enrolled adults 1,252 between relationships the evaluate to conducted was analysis post-hoc A experiences. treatment patient of monitoring automated via receiving a therapeutically effective dose during the 12 months following treatment start and patient characteristics (race/ethnicity, gender, neighborhood deprivation, medication drug class, pain severity, chronic pain, most recent A1C, also BMI, We language tests). (chi-squared tables contingency and test t Student’s using spoken, assessed were statistics Descriptive Medicaid). Medicare, conducted a logistic regression analysis to assess the independent association of race and ethnicity and the Anticonvul outcome. sants and antidepressants were prescribed most About frequently. half of all patients within the study received a effective dose oftherapeutically medication. Of the variables examined, only pain interference [3rd quartile: 1.76, (1.21,2.55)], 4th quartile:1.95, thera a of receipt with associated significantly statistically were (2.71,4.84)] 3.62, [ prescribed medication of type and 3.03)] (1.25, peutically effective dose. Race/ethnicity were notassociated with receiving a therapeutically effective This dose. may suggest that disparities are primarily related to opioid prescribing in acute settings of care. more However, analysis is needed to confirm these findings. The purpose of this study was to investigate the association between race and ethnicity and the likelihood of receiving a therapeuti a receiving of likelihood the and ethnicity and race between association the investigate to was study this of purpose The 1 Texas Tech Health Science Center School of Medicine; 2 Division of Research, Kaiser Permanente, Oakland, CA Health Science Center School Tech Texas 1 Rachel Nwaneri, 1 Lin Ma, MS, 2 Alyce S. Adams, PhD 2 S. Alyce Rachel Nwaneri, 1 Lin Ma, MS, 2 ropathy The Influence of Race and Ethnicity in Therapeutic Dosing Among Patients Newly Treated for Painful Diabetic Peripheral Neu Treated Newly Among Patients Therapeutic Dosing The Influence of Race and Ethnicity in MS1-2 NWANERI, RACHEL MS1-2 NWANERI, School: School of Medicine WT nuclear WT circularity averaged only 1% than larger All HFE other = circularity features 0.42). (P were more atypical in the HFE cancer nuclei (P < 0.00001 for each comparison). WT nuclei, on average, had 29% larger area, 44% larger brightness and c.v., nuclei. WT appeared less aggressive than the nucleolar area, than those of HFE nuclei. From this, the HFE nuclei 66% larger Previous studies from our lab explored the possible relationship between hemochromatosis and the colon by inducing hemochro the In polyps this were study, analyzed for the progression of colon cancer using the computer program FIJI (FIJI Is Just ImageJ), an open source program developed by the NIH geared toward Thescientific characteristics image of analysis. nuclei are important in determining malignancy of tissue due to the uniquely identifying characteristics of cancerous cells compared to healthy cells. FIJI was used to collect data on the size, shape, and color of each nuclei via the area, measurements brightness, of and circularity, were compared. intestine epithelial cells of each experimental model large nucleolar area; the nuclei of the small and tion of iron and oxidative stress. Liver cirrhosis and hepatocellular carcinoma are the most notable presentations of the disease, but disease, the of presentations notable most the are carcinoma hepatocellular and cirrhosis Liver stress. oxidative and iron of tion is less known. other organs the involvement of cancer. colitis-associated a and cancer driven genetically a cancer: colon of models experimental different two with mice in matosis coli) and the Apc (adenomatous polyposis mutation in was produced in mice with a heterozygous driven cancer The genetically colitis-associated cancer was produced by administering a colon-specific carcinogen azoxymethane and cyclic administration of stain. sectioned and stained with an H&E The polyps were an irritant. dextran sulfate sodium, Hemochromatosis is a genetic iron overload disease leading to late onset manifestation of organ damage due to the slow accumula slow the to due damage organ of manifestation onset late to leading disease overload iron genetic a is Hemochromatosis Anna Nevels; Mitchell Wachtel, M.D., Vadivel Ganapathy, Ph.D. Ganapathy, Vadivel M.D., Wachtel, Mitchell Anna Nevels; MS1-2 NEVELS, ANNA NEVELS, MS1-2 Setting of Hemochromatosis Colon Cancer in the in Colitis and Pathological Changes Analysis of

ABSTRACTS 80 School: SchoolofMedicine clinical effects. undesired as well as desired both include may This effects. clinical its understand better to us enable will action of mechanism lar pLGICs. eukaryotic in site binding similar a uses bupropion Awhether probe bupropion’sof understanding detailed more molecu We further used Cys scanning of key residues in the identified binding site to substantiate our results. Further studies are needed to tested. was constructs GLIC engineered these of inhibition bupropion the then and activation GLIC half-maximal yields that tion Two-electrode voltage-clamp recordings in Xenopus oocytes were used to examine the effect of mutations on the proton concentra within the α-helical transmembrane domain with the goal to interfere with bupropion’s ability to bind and inhibit channel function. bupropion. for residues site Webinding potential analyze to mutagenesis site-directed and studies docking acids amino engineered is a proton-gated cation-selective channel that exists that structurally contains an extracellular and transmembrane domain. We used GLIC (GLIC). channel ion ligand-gated violaceus Gloeobacter the is pLGICs of pharmacology and function, structure, investigate to used extensively been (5-HT3AR). has receptors that Aserotonin homologue and prokaryotic (nAChR) receptors acetylcholine nicotinic particular in eukaryotes, in receptors Cys-loop called also (pLGICs) channels ion ligand-gated pentameric inhibits also binding todopamine and norepinephrine transporters toinhibit reuptake in thebrain.Morerecently, itwasshownthat bupropion The aminoketone bupropionisclinically used asanantidepressantandsmokingcessationdrug. action involves The mechanismof bock, TX, USA. and MolecularBiophysics, Texas Tech UnivHlthSciCtr, Lubbock, TX, USA,4DeptCellP, Texas Tech UnivHlthSciCtr, Lub- and MolecularBiophysics/SchoolofMedicine, Texas Tech UniversityHealthSci.Cntr., Lubbock, TX, USA,3CellPhysiology Physiology andMolecularBiophysics/SchoolofMedicine, Texas Tech UnivHlthSciCtr, Lubbock, TX, USA,2CellPhysiology Dubem Onyejegbu1,JessicaShepherd2,ElhamPirayesh3, Akash V. Pandhare3,Zackary R.Gallardo3,MichaelaJansen4.1Cell Identification ofthebupropion bindingsiteinGLICusingsite-directed mutagenesis MS1-2 ONYEJEGBU, DUBEM School: GraduateSchoolofBiomedicalSciences benefits ofimplementingstudent-createdcontentcomparedtothecurrentmedicalschoolcurriculum. COAthe in utilized those curriculum. year first the of block the describe will results the correct, was hypothesis the that Assuming as perceptions positive similar elicited content student-created if demonstrate help survey,will satisfaction the alongside none, or Results/Conclusion: Comparing the results from the pre and post quizzes between students who used the modules, questions, both, quality ofthevideomodules/questions,aswellgivetheircommentsandcritiques. and usefulness the of perception their rate to students allowing unit, the following out sent was survey satisfaction a Furthermore, A Pre and Post unit quiz with identical questions were used to assess the improvement in the students’ understanding of the material. block. the of portion Renal the of start the at distributed be then would resources these of Both questions. 3rd and 2nd, 1st, with created were rationals with banks question addition, In material. lecture the of most covering modules video of creation the guide helped information This difficult. most the be to believed were topics which ascertaining in aided assessment Needs-Based AMethods: tion ofMOS,willaugmentthelearningexperienceforMS1s. if the implementation of student-created content, specifically, review videos and question banks with rationals during the Renal por the benefits of student-created video modules in blocks outside of COA have not been assessed. Therefore, this project will explore modules created by Teaching Assistants (TAs) who have previously taken the learning the video same from class. with benefited Despite have the students struggle favorability (COA), Oriented for Anatomy Clinically these often as modules, such blocks, block previous However,in (MOS) material. Systems Organ Multiple the in enrolled (MS1s) students medical First-year Introduction: Ozman JavierOchoa,JohnPelley School RenalPhysiologyUnit Assessing theEffectsofImplementingStudent-Created Teaching Videos andQuestion AnalysiswithintheFirst-Year Medical MS1-2 OCHOA, OZMAN - - - 81 ABSTRACTS School: School of Medicine Branchial cleft cysts are congenital abnormalities that arise pain neck from with ER the to improper presented female old 13-year obliteration A of gestation. of week the fourth the during develop to branchial begins apparatus branchial cleft and/or pouch. The and left anterior neck The swelling. patient states that it began with a sore throat and dysphagia. Physical examination reveals sig- nificant tenderness and soft tissue swelling in the left thyroid region. Incision and drainage, fine needle aspiration, and intravenous cm 2.7 x cm 2.9 a revealing ordered, was contrast intravenous with neck CT infection. suspected for administered was clindamycin x 2.5 cm rim enhancing lesion involving the superior pole of the left thyroid lobe. Ultrasound-guided fine needle aspiration shows rim a of location characteristic The parvula. Veillonella and haemolyticus, Haemophilus intermedius, Streptococcus of presence the otolaryngologist An cyst. cleft branchial fourth a of diagnosis a suggests gland thyroid the of lobe left the involving lesion enhancing tran- excision or transorally, tract of cauterization (MLB), bronchoscopy and microlaryngoscopy performing recommended initially scervically with a However, the hemithyroidectomy. patient showed signs of visible improvement. Most recent CT scan revealed no accumulation of lesion or Thismasses casefollowing revealedfine that needle fourth aspiration. branchial cleft cysts should be of decade first the within is presentation usual the though even group age this in patients for diagnosis differential the in considered be should options These drainage. and incision over options treatment favorable more are aspiration needle fine and Antibiotics life. considered more frequently due to their higher success rate. Rachel Nwaneri, BS, Nimra Pasha, BS, Winslo Idicula, MD, Roy Jacob, MD Winslo Rachel Nwaneri, BS, Nimra Pasha, BS, An Unusual Cause of Sore Throat and Dysphagia in a Teenage Throat An Unusual Cause of Sore MS1-2 PASHA, NIMRA MS1-2 PASHA, School: School of Medicine Conclusion: We Conclusion: We report a rare case of pediatric KFD and subsequent SLE within a year and timeline. a half, a very rare combination and Case report: We herein Case report report: We a 13-year old Hispanic girl with no significant medical historywho presented to the emergency de- and loss weight extensive into evolved that dizziness and headaches, (FUO), origin unknown of fever persistent with (ED) partment 1.5 of period a over done up work rheumatology and disease, infectious oncology, hematology, repeated extensive, An lesions. scalp steroids of course short a After KFD. suggesting lymphadenitis necrotizing histiocytic revealing biopsy node lymph a to led months and normalizing symptoms, the patient presented to the ED 17 months later with symptoms of a recurrent KFD. She and extremities, was and face her over rashes non-blanching seen vasculitic diffuse including symptoms, worsening with clinic a in later week antibodies anti-Smith and ANA positive revealed Labs arthritis. no with myalgias and arthralgias by accompanied fatigue extreme methylprednisolone and hydroxychloroquine. leading to a diagnosis of SLE and treatment along pancytopenia, Introduction: Introduction: Kikuchi-Fujimoto Disease (KFD), also known as histiocytic necrotizing lymphadenitis, is a self-remitting, immune- in particularly old, years <40 adults young seen commonly characteristics histopathological unique having disorder rare mediated Asian There is populations. a strong association between KFD and Systemic Lupus Erythematosus (SLE), but reports of KFD and years) for pediatric populations are rare. within a short time frame (<2 subsequent SLE occurring Chibuzo O’Suoji, MD, MS, John Rafael, MS1 MD, MS, John Chibuzo O’Suoji, MS1-2 O’SUOJI, CHIBUZO O’SUOJI, MS1-2 Case Study A Lupus Erythematous: with a Relapse of Systemic Disease Kikuchi-Fujimoto’s Pediatric

ABSTRACTS 82 School: School ofMedicine *The specific name ofthepharmacywasnot includedduetoconfidential statere the reclaimeddrugsatthis TDCJ facility. and hardware (estimated cost $4000), this would decrease monthly discrepancy in reclaim credit and allow for better monitoring of cost is much less than the average reclaim credit for one month. With the implementation of a scanning system, including software the since system scanning a drug implement to beneficial be would it that determined was it analysis, cost-benefit the completing Results: The data analysis showed the percent reclaim credit varied from 7% to 51% in the twelve months that were analyzed. After every monthandanalyzedtofindanytrendsinthedata. for calculated was credit reclaim was which costs prescription total the of percentage The month. per credit reclaim the and costs prescription total the separating and months twelve past Methods: the for invoices monthly the gathering by done was project This system atthis TDCJ facilitytoreducethediscrepancyincreditandbettermonitorreclaimeddrugs. scanning drug a of implantation proposed the evaluate to analysis cost-benefit a conduct to is study this of purpose Objective: The drug receiving, reclaiming,anddestroying. of methods inefficient have to shown was and site on inspected was facility TDCJ the Furthermore, drugs. reclaimed these for received credit of amount monthly the in discrepancies large was there Thus, (UTMB). Galveston Texasat of Branch Medical seller,University the by issued being credit actual the and refund/credit a for returned being were that drugs reclaimed of number the checking of way efficient no was there that shown was it conducted, was audit internal an After (TDCJ). Justice Criminal of Department Texas the for WestTexas in pharmacy a manages Center Sciences Health University TechTexas The Introduction: aged Center Dhruv Patel, MBA, MSII School of Medicine, Dr. Cynthia Jumper, MD, MPH, Texas Tech University Health Sciences Center Man- Medical Business:Cost-Benefit AnalysisofImplementing aDrugScanningSystem MS1-2 PATEL, DHRUV School: SchoolofMedicine of communitymentalhealthcareandmoreEDresourcesforpatients. improvement for calls that issue health public meaningful a is health mental for ED the using population sizable The Conclusion: remain intheEDanaverageof80minuteslonger. with or without mental health symptoms wait similar amounts of time to see a doctor in the ED, but those with mental health issues Patients urgent). score=more (lower sample health non-mental the in 3.3 of average the than lower significantly 2.8, was visit for visits were for mental health symptoms alone. Average triage score for adults for whom a mental health concern was the sole reason presenting issue. This translates to about 5.9 million ED visits annually related to mental health symptoms, of which 2.4 million ED Results: About 5% of all ED visits involved a mental health concern, with about 2% being a visit where mental health was the only to 5(non-urgent). for visit entered during the triage process, and individuals are given a score for their urgency to be seen ranging from 1 (Immediate) reasons three to up provides annually.case collected Each visits department emergency of sample representative vey,nationally a Data & Methods: Data for this study include all individuals age 18+ in the 2009-2015 National Hospital and Ambulatory Care Sur times, length ofvisit,andtimefromfirstMDcontacttodischarge inEDvisitswherementalhealthwasidentifiedasareasonforvisit. wait scores, triage explores study This populations. these of demographics the understand to needed is research more but have poor access to primary care. Research has who found individuals mental to health including ED needs, visits health have of increased range in wide both a pediatric serve and U.S. adult the populations, in (ED) departments emergency Hospital Background: Center DepartmentofPublicHealth,Lubbock, TX Sciences Health TexasTechUniversity ^2 TX; Lubbock, Medicine, of School Center Sciences Health TexasTechUniversity ^1 Bianca Patel^1,JeffDennis,PhD^2,Hijab Ahmed^12,CainLara^2 Emergency departmentuseformentalhealthsymptoms:Findingsfrom 2009-2015NHAMCSdata MS1-2 PATEL, BIANCA - 83 ABSTRACTS - AC gers and metal jewelry. gers and metal jewelry. School: School of Medicine Conclusion: PUBM can be used to facilitate the healing of otherwise large lacerations and wounds in difficult locations that can that can that locations difficult in wounds and lacerations large otherwise of healing the facilitate to used be can PUBM Conclusion: suc- the highlights case This reconstruction. flap or grafts skin for need the obviating cases many in close and manage to difficult be cessful use of PUBM implantation on a avulsion large laceration on a particularly challenging location of the forehead with 100% healing and wound closure achieved. Results: Patient presented October 30, 2018 with multiple dog bite wounds including a 4.5 cm wide 0.7 cm deep and 7 cm long with long cm 7 and deep cm 0.7 wide cm 4.5 a including wounds bite dog multiple with 2018 30, October presented Patient Results: tunneling stellate avulsion laceration to the left forehead with a large area of tissue loss extending to the galea. ENT kept wound Oc- On day. a twice dressings changed and tape hypafix gauze, non-adherent telfa with adaptic and ointment Bacitracin with moist covering implanted was MicroMatrix of mg 200 of total A implanted. was PUBM and debrided, was tissue nonviable 2018 31, tober the tunneled areas. The entire 7 X 10 cm sheet was implanted and secured to skin with vicryl Adaptic suture. was secured to skin with prolene suture and Hydrogel was applied to maintain hydration. completely Wound healed with one application of PUBM, despite the challenging location, over 12 weeks. Methods: We Methods: We present a case of a 20-year-old male who underwent xenograft ER initial the implantation from UMC at EMR utilizing of review chart via PUBM collected were information and for Data loss. tissue soft significant a with forehead dog bite to the management, and clinic follow up for one year. consultation, initial acute care, surgical visit, ENT Ebrahim Payberah BS, Jasmin Rahesh MS, Sterling Rosqvist, Beatrice Caballero BS, Catherine Ronaghan MD F Ebrahim Payberah BS, Jasmin Rahesh Porcine urinary bladder matrix (PUBM) IntroductionL is a new xenograft used reinforcement for and surgical management of soft of lining inner the in propria lamina and membrane basement the from derived matrix extracellular acellular an is It wounds. tissue It facilitates porcine constructive urinary remodeling bladder. and wound healing via its components such as intact cellular signal- ing proteins. MS1-2 PAYBERAH, EBRAHIM MS1-2 PAYBERAH, Laceration Urinary Bladder Matrix to Forehead Implantation of Porcine Case 2: A 22-year-old male, presented A Case to 2: UMC with deep circumferential burns to the neck. The patient was attempting to charge his cell phone when his metal necklace contacted an exposed wire on the charging cord. The metal necklace heated up around his neck which caused full thickness thermal burns. While the metal chain was heating, the patient attempted to rip the necklace off with his right hand, resulting in additional burns on his right palm. The burns were surgically treated the following day with exci Conclusions: Both cases demonstrate the potential of thermal burn formation via electrical resistance This in study metal jewelry. hazards that can result from simple phone char aims to bring public awareness to the potential Case 1: A healthy 14-year-old male was transferred to UMC sustaining full thickness circumferential thermal burns to his neck. While the patient was sleeping, the electrical conduction from an extension cord to his phone charger became overheated and at- tracted his This metal necklace. chain As made contact a between result the and of charger extension this cord. contact, the patient awoke from the initial electrocution to find his necklace overheated, red hot, and causing his shirt to catch on fire, resultingthermal burn injury. in a sion and grafting. School: School of Medicine Introduction: Introduction: Electrocutions from both high and low voltage exposures can cause serious injuries and account for an estimated 2% to 5% of burns admitted to the hospital. Low voltage injuries are those less than 1000 volts while most occur house-hold electronics injuries are burn Serious jewelry. metallic and sources electrical between contact of result a are injuries electrical Many volts. 120 of cases unusual two present We super-heat. to it causing source electrical exposed the to fused becomes jewelry metallic the when low-voltage electrothermal injuries resulting in significant burn injuries when metallic necklace jewelry contacted phone charger plugs. Shree Patel, Grant Sorensen, MS, PhD, John Griswold, MD, FACS MS, PhD, John Griswold, Grant Sorensen, Shree Patel, MS1-2 PATEL, SHREE PATEL, MS1-2 and Phone Chargers Caused by Necklaces Unusual Injuries Neck Burns: Electrothermal

ABSTRACTS 84 School: SchoolofMedicine and exercisebaseduponthebody’s circadianrhythm.However, thereisaneedforadditionalstudiestoexplorethistheory [78]. increase in basal metabolic rate (BMR) [76, 77]. The future of weight loss may include greater integration and optimization of diet fat mass (FM) while resistance training shows the highest adherence to exercise rate and builds the most muscle mass, linked to an illustrated the most significant ability to establish weight loss. HIIT produces the largest difference in body fat rate (BF%) and body the other diets previously mentioned. Of the many exercise modalities, high-intensity interval training (HIIT) and resistance training to comparison in limitations/contraindications few relatively have to appears diet Mediterranean the although limitations, inherent with comes diets these of Yet44]. each 38, 28, 27, [14, weight lose to patients help can Fasting Intermittent and Mediterranean, Paleo, Keto, as Atkins, such diets that indicates literature current The period. intervention an during effectiveness their assess and may assist patients with weight loss. This study aims to analyze the assortments of diets and exercises available to public knowledge progress. However, a correct understanding of the body’s metabolism and the selection of an appropriate diet and exercise program individual’s an deter can factors emotional and mental, physical, as difficult be can treatment loss weight a Beginning [7]. together weight loss [7]. The preferred approach for losing and maintaining weight loss is through is the combination obesity of dieting and for exercising treatment best the that found has Research [4]. cancer of types certain and strokes, disease, heart hypertension, tes, diabe II type including issues health-related numerous to linked been has Obesity [5]. category either into falling population the of two-thirds with States United the in epidemic growing a are kg/m²) ≥30 (BMI obesity and kg/m²) 25.9-29.9 (BMI Overweight Cody Perry, MohammedPourghaed Exercise andNutritionalGuidelinesforWeight LossandWeight MaintenanceintheObeseFemale MS1-2 PERRY, CODY School: SchoolofMedicine Midline ShiftRevisited.JournalofNeurotrauma28,203-215(201 VolumeHematoma Injury: and Brain TraumaticSevere and Moderate in Outcome TomographyComputed and al. et B. 2.Jacobs, 1.Kang, J.etal.Clinical Analysis ofDelayedSurgical EpiduralHematoma.KoreanJournalofNeurotrauma11, 112-117 (2015). the robustnessofcurrentfindings. for counseling families of children who suffer traumatic intracranial hematomas. However, we will need larger numbers to confirm relation between hematoma volumes and outcome (p= 0.001). This information will be very useful for medical cor decision significant making a and was There (6%). fatality one was there and outcome good a had 75% literature. current with consistent is which come Scale, which relates degree of brain injury to expected degree of recovery. The mean hematoma volume was 32.3 cc (6 -139), hematomas evacuated between January 1014 and December 2018. Hematoma volumes were related to scores on the Glasgow Out- intracranial had outcome. who age of to years five it under patients relating sixteen of scans and CT the volumes from measured hematoma were volumes brain measuring and Hematoma of feasibility the determine to study a out carried we Thus, making. of death and disability. Establishing a correlation of hematoma volume to outcome will allow for triage and rapid medical decision- Traumatic brain injury is aheterogenous disorder withvariable outcome. Furthermore, intracranial hematomas are a common cause Belirgen M.D.,LaszloNagyM.D. Muhittin M.D., Jacob WeiRoy Brandon B.S., B.A., Perez-Arnold Laura Investigator), (Principal M.D. Igbaseimokumo Usiakimi Intracranial HematomaVolume andOutcomeinTraumatic BrainInjury MS1-2 PEREZ-ARNOLD, LAURA 1). - - 85 ABSTRACTS - School: School of Medicine The Texas Tech University Health Tech Sciences The Center Texas Free Clinic provides eye examinations and treatment for uninsured patients in Lubbock, Founded Texas. over ten years ago as a primary care clinic, it was expanded in 2014 to incorporate an ophthalmology service for the clinic’s large diabetic and hypertensive population. The purpose of this study is to analyze and diagnoses patient at the clinic to improve demographics understanding of our patient population and guide future the expan- ophthalmology clinic’s Asion retrospective efforts. chart review of ophthalmology patients seen between March 2018 and January 2020 was performed. Charts were reviewed for diagnoses and demographics (age, gender, ethnicity, income). The results provide a breakdown of our patient population and by income age, ethnicity, and gender, identify the most commonly encountered conditions at our clinic. To best serve our patient population, we need to understand the conditions they suffer from andfor treatments theirand care eye living targeted provide to resources future allocate conditionsbest can we where highlights (basedanalysis This demographics). upon this vulnerable patient population. Rachel Wagstaff, Derrick B. Graham, Joshua A. Peterson, Kelly Mitchell, Kenn Freedman, Fiona Prabhu Derrick B. Graham, Joshua Wagstaff, Rachel Analysis of Patients and Conditions Seen at a West Texas Free Ophthalmology Clinic Free Texas at a West Analysis of Patients and Conditions Seen MS1-2 PETERSON, JOSHUA MS1-2 PETERSON, School: School of Medicine 1.Siddiqui, Afzal A. and Siddiqui, Sabrina Z. “Sm-p80-Based Schistosomiasis Preparation Vaccine: for Human Clinical Trials.” 33, No. 3 Vol. March 2017, in Parasitology, Trends Given this, an effective Schistosoma vaccine isdesperately needed. Here we examine such a vaccine for S. japonicum, the major pro- calcium-activated japonicum S. the of subunit large a protein, Sj-p80 the targets vaccine The schistosomiasis. Asiatic of cause tease calpain, which plays a major role in membrane The biogenesis Sj-p80 and vaccine renewal. functions to inhibit egg hatching and decrease egg retention, expulsion, and transmission—providing both prophylactic and therapeutic thebenefits. way However, in which a vaccine is produced can effect its Here immunogenicity. we examine the effects of five protein buffer used in vaccine production—two important components of Schistosoma immune response1. production on immunoglobulin and cytokine Schistosoma is a parasitic helminth that causes the disease known as Schistosomiasis, a neglected tropical disease endemic to tropical disease endemic neglected disease known as Schistosomiasis, a that causes the helminth Schistosoma is a parasitic Africa, Asia, the Eastern Mediterranean, the Caribbean, and South America. It is estimated that 200 million people with Schistosoma worldwide, with an additional 779 million people The at three risk. are most common species of this trematode – S. infected mansoni, S. japonicum, and S. haematobium – can cause serious symptoms such as jaundice, hepatosplenomegaly, portal hyper more, tension, these esophageal parasites varices, cause and a What’s hematemesis. combined annual mortality of 280,000 deaths. The persistence of Schistosoma, despite eradication efforts, is due in part to its life cycle, which involves both humans and aquatic the Additionally, anti-helminthic snails. praziquantel, while an effective treatment, isn’t readily available in endemic areas and its result in resistance1. widespread use could NOTE: This NOTE: is a joint submission for Rebecca Kernen and Christopher Peterson. Both were sponsored by the summer medical re- Public of Master | Sciences Medical Graduate | 1-2 years students “Medical the under poster the presenting are and program search Health” category. Rebecca Kernen, Christopher Peterson, Adebayo Molhehin, Weidong Zhang, and Afzal A. Siddiqui A. Afzal Zhang, and Weidong Molhehin, Adebayo Peterson, Christopher Rebecca Kernen, MS1-2 PETERSON, CHRISTOPHER PETERSON, MS1-2 Mice in C57 S. japonicum Vaccine Elicited by Immune Response

ABSTRACTS 86 School: School ofMedicine Keywords: upper extremityfractures,ultrasound, diagnosticaccuracy children, servingasanalternative diagnosticmodalitytoplainradiographs. in fractures extremity upper non-elbow for accuracy diagnostic excellent has ultrasound suggests evidence Current Conclusions: p<0.01). non-elbow, vs (elbow ultrasound of accuracy diagnostic affect would sites fracture the (95% suggested Meta-regression 0.96 0.94-0.97). CI: of AUROC an with 0.02-0.16), CI: (95% 0.06 ratio: likelihood negative and 3.7-14.4) CI: (95% 7.3 ratio: likelihood sis for elbow fracture showed ultrasound has a sensitivity: 0.95 (95% CI: 0.86-0.98), specificity: 0.87 (95% CI: 0.76-0.94), positive likelihood ratio: 0.05 (95% CI: 0.03-0.07), with an area under ROC (AUROC) curve of 0.98 (95% CI: 0.97-0.99). Subgroup analy negative and 10.8-41.5) CI: (95% 21.1 ratio: likelihood positive 0.91-0.98), CI: (95% 0.95 specificity: 0.93-0.97), CI: (95% 0.95 sensitivity: a has extremities upper the of fractures for Ultrasound meta-analysis. the in identified were Results: studies Thirty-two non-elbow vs (elbow site fracture of fractures) wasalsoperformed.Meta-regressionperformed todetermineifthesiteoffractureaffecteddiagnosticaccuracy analysis Subgroup model. bivariate random-effects the using conducted was fractures for ultrasound of accuracy diagnostic the of (PRISMA-DTA).Meta-analysis TestStudies Diagnostic Accuracy of Review Meta-analysis and Systematic a for Items Reporting Preferred using reported is study The “children”. and extremities” upper of “fractures Methods: Databases were searched from inception through November 2019 using pre-defined index terms, including “ultrasound,” to summarizethediagnosticaccuracyofultrasoundforupperextremityfracturesinchildren. Objective: Ultrasound has an excellent diagnostic accuracy for fractures that is reportedly comparable to plain radiographs. We aim John Rafael;Po-Yang Tsou, MDMPH; Yu-Kun Ma,MD; Yu-Hsun Wang, MDMPH;Jason T Gillon, MD Diagnostic Accuracy ofUltrasoundforUpperExtremity Fractures inChildren: A SystematicReviewandMeta-analysis MS1-2 RAFAEL, JOHN School: GraduateSchoolofBiomedicalSciences and implementeffectivestudymaterialstohelpbetterpreparestudentsfortheirexamsfuturecareersinmedicine. if they felt they were effective study materials. The results of this project will be used to help medical schools and educators design the review modules. After completion of the Gastrointestinal Physiology unit, a survey will be sent out to first year students to assess student respondents would of have 75% liked that to showed have review survey modules this that of included practice results questions. The learning. The results for of effective this most survey be were used would to materials create study of kind what asking correct and incorrect answers. Additionally, a Needs Assessment survey was sent to students who had already completed the course, questions written for each module were presented in a similar animated style through PowerPoint and had detailed explanations for animations, drawings, and charts to make the information more interactive and help students retain important information. Practice textbook as well as clinically significant information that may be tested on licensing exams such as STEP 1. The modules contained required material, lecture the to related that topic one covered module Each PowerPoint. using created were Physiology intestinal Gastro- covering modules review Interactive students. medical to concepts important teaching for modules Physiology intestinal Gastro- of effectiveness the determine to was project this of pace. aim own The their at content study to them allow and exams for view modules covering important material with practice questions to test their understanding could be helpful in preparing students re- online short students, to presented information of amount overwhelming the combat to order In training. their of stage next the Medical educators are always searching for ways to streamline pre-clinical curriculum to help students succeed and feel prepared for Kenna Provost;Dr. JannetteDufour, Ph.D. Studying theEffectivenessof“Bite-Size”ReviewModulesonGastr MS1-2 PROVOST, KENNA ointestinal PhysiologyConceptsinMedicalSchool , meta-analysis . - 87 ABSTRACTS - - - School: School of Medicine vival. Prompted by this data, we examined SLC38A5 expression in 10 pancreatic cancer cell lines and 10 patient-derived xenografts patient-derived 10 and lines cell cancer pancreatic 10 in expression SLC38A5 examined we data, this by Prompted vival. then We samples. both in higher markedly was expression SLC38A5 line. cell pancreatic normal a in expression to it compared and monitored the functional activity of SLC38A5 in two pancreatic cancer cell lines (AsPC-1 and As BxPC3). multiple transporters recognize glutamine, we used the unique property of SLC38A5 to tolerate Li+ in place of Na+ to measure its transport function. Li+-coupled glutamine uptake was evident in both cell lines; the transport was also influenced by a transmembrane H+ gradient, corroborating We then Wntinvolvement examined signalingof H+ in SLC38A5efflux upregula coupled to Li+/glutamine influx. tion since this pathway is activated in pancreatic Treatment cancer. of BxPC3 cells with a Wnt agonist increased the and expression function of SLC38A5 whereas treatment with a Wnt antagonist had the opposite effect. These studies show that SLC38A5 is other with along glutamine provide to SLC38A5 of ability the on Based signaling. Wnt via likely cancer, pancreatic in upregulated amino acids and induce intracellular alkalinization, we predict that SLC38A5 functions as a tumor promoter in pancreatic cancer for cancer therapy. and could have potential as a novel pharmacologic target SLC38A5 is a transporter for selective amino acids; it mediates the Na+-coupled influx of its substrates with efflux of H+. SLC38A5 H+. of efflux with substrates its of influx Na+-coupled the mediates it acids; amino selective for transporter a is SLC38A5 mul- has glutamine As alkalinization. intracellular causes and cells to acids amino other and glutamine provides it because unique is tumor a as serve to suited uniquely is SLC38A5 synthesis, DNA promotes alkalinization intracellular and functions biological tiple marked of evidence found We cancers. in expression SLC38A5 for databases public examined first we rationale, this With promoter. upregulation in pancreatic directly cancer, related to the stage and grade. Patients with higher expression show worse overall sur Michael A. Ramirez, Kei Higuchi, Yangzom D. Bhutia, and Vadivel Ganapathy Vadivel D. Bhutia, and Yangzom A. Ramirez, Kei Higuchi, Michael SLC38A5, a unique amino acid transporter, is upregulated in pancreatic cancer: A potential tumor promoter and an actionable tumor promoter potential A cancer: pancreatic in is upregulated transporter, amino acid SLC38A5, a unique therapy? for cancer target MS1-2 RAMIREZ, MICHAEL School: School of Medicine ing calcium and Vitamin D, ing the calcium estimated acknowledge Vitamin and daily that dose per bottle We was not more D than daily. 2000 Vitamin IU doses D Vitamin acknowledged has Medicine of Institute The D. hypervitaminosis in result not should D vitamin of IU 2000 taking D levels slowly declined after The cessation decline of and OTC normalization supplements. of of 4000 Vitamin IU daily are safe. of etiology the likely were supplements these that indicate supplements OTC her of cessation after calcium urine and 25(OH)D her her hypervitaminosis D. Over the counter supplements are regulated not and FDA as such may contain varying amounts of active We patient. our in seen as toxicity incidental prevent may which regulation FDA from benefit would medications OTC ingredients. also conclude that there is a wide of margin safety with vitamin D. Future research should measure free 25(OH)D and 1,25(OH)D toxicity. levels in assessing potential vitamin D Vitamin D Vitamin deficiency is highly prevalent and there are increasing reports of vitamin Dmostly toxicity, related to misuseis status D ofVitamin fatal. be may over and D hypervitaminosis accompanies usually toxicity D Vitamin supplements. (OTC) counter the assessed by measuring 25(OH)D levels (normal range 30 to 100 ng/ml). Current guidelines indicate 25(OH)D values over 150 ng/ or clinical without ng/mL) 196 (25(OH)D D hypervitaminosis marked with case a report We toxicity. D Vitamin of risk increase ml Her serum calcium, phosphorus and biochemical 1,25(OH)2D toxicity. were all normal. She was taking OTC supplements includ Jasmin Rahesh MS MBA, Victoria Chu MS MBA, Alan Peiris MD PhD Alan Peiris MD MBA, Chu MS Victoria MS MBA, Jasmin Rahesh MS1-2 RAHESH, JASMIN RAHESH, MS1-2 D without Toxicity Hypervitaminosis

ABSTRACTS 88 School: SchoolofMedicine beneficial outcomes. skeletal pain. Other treatment modalities either possessed a lack of evidence, or only had low quality evidence to support claims of therapy, musculo- heat/cold for supported options treatment therapy, as exercise supplements specific and education, neuroscience published on Pubmed and Cochrane Library. Treatments were grouped into tiers based on current available evidence. Evidence best taping, transcutaneous electrical nerve stimulation (TENS), cupping, and homeopathy. Data was collected from journals and studies supplements (CBD, antioxidants, glucosamine, etc.), chiropractic spinal manipulation, acupuncture, dynamic compression, kinesio therapy, education, exercise controversy. neuroscience treatment, scientific heat/cold despite include popularity Topics gained has that or pharmacological, or surgical considered not is that treatment any as defined are study the in modalities relaxation ternative pain. Al- musculoskeletal with female active the for modalities relaxation alternative the evaluate to is study this of purpose The Dr. MimiZumwalt,StephenRossettie, Adin Mizer Alternative Treatment Modalitiesforthe Active FemalewithMusculoskeletal Pain MS1-2 ROSSETTIE, STEPHEN School: SchoolofMedicine metastasis at26monthspost-resection. and/or recurrence of evidence no was there and procedures, these given expected as progressed patient The hand. affected the of function improve to performed were osteotomy rotational and fusion, carpometacarpal tenolysis, Subsequent margins. wide with tissue malignant all removing resection, ray 5th and amputation hand partial including resection surgical with treated was patient Our literature. the in enchondroma prior without chondrosarcoma hand multifocal of cases other no are there knowledge, Toour chondrosarcoma in a patient who had none of the aforementioned conditions and presented with no evidence of prior enchondroma. multiple from hand multifocal arose of case exostosis. a hereditary present or reported We syndrome, Maffucci disease, Ollier’s with been patients in enchondromas have that cases multifocal few very the and singular, typically are lo- Chondrosarcomas this cation. in malignancy common most the being chondrosarcomas with hand, the in occur rarely tumors bone malignant Primary BBA; BrendanMackay, MD Hunter Jones, BS; Jacob Murphree, MD; Joash Suryavanshi, BA; Bradley Osemwengie, BA; Sterling Rosqvist, BS; Cameron Cox, Multifocal Chondrosarcoma oftheHand:CaseReportandReviewLiterature MS1-2 ROSQVIST, STERLING School: SchoolofMedicine marker andmayremainelevatedinthepresenceofanormalserumcalcium. sensitive more a is it as measurements calcium ionized include should calcium, serum total the on focus which guidelines, current elevated throughout treatment. We believe vitamin D deficiency should be carefully monitored in primary hyperparathyroidism. The values declined in parallel with theelevation in vitamin D. Although hertotal calcium normalized, her ionized calcium remained patient’s The PTH normalized. calcium total her thirteen-months, for D vitamin with deficient. treatment D After vitamin was but function renal and albumin normal a had She nephrolithiasis. of history and scan parathyroid positive a with hyperparathyroidism hypercalcemia. Weprimary of of exacerbation case avoid a to present tepidly administered been has replacement D vitamin while PHPT in treatment definitive the Traditionally,PTH. been intact has increasing parathyroidectomy and calcium urine reducing by defi- this of hyperparathyroidism primary of diagnosis unclear. the is impact hyperparathyroidism management Vitamin can primary deficiency in D ciency optimal The (PHPT). hyperparathyroidism primary with patients in common is deficiency D Vitamin Center ClinicalResearchInstituteandDepartmentofInternalMedicine,Lubbock Sciences Health TexasUniversity Techb Texas, Lubbock Medicine, of School Center, Sciences Health TexasUniversity Techa Alexsandra P. Rojas,BAa,KristenFain,BSa, Alan N.Peiris,M.D,PhDb Resolution ofhypercalcemia inprimaryhyperparathyroidism withVitamin Dreplacement MS1-2 ROJAS, ALEXSANDRA Texas 89 ABSTRACTS - - - Conclusions: Patient outcomes are improved with timely detection and correction of external ear deformities. Our study identified gaps in the correct identification of such deformities, particularlyamong Pediatric residents and junior defor to residents them exposing curriculum, digital quantified a from benefit may types specialty and levels training all of Residents types. in all specialty School: School of Medicine ing Microtia Grade 3, Question Mark Ear and Cryptotia as compared to junior residents (PGY 1-2). Senior residents also performed also residents Senior 1-2). (PGY residents junior to compared as Cryptotia and Ear Mark Question 3, Grade Microtia ing residents Surgery Plastic and Otolaryngology (p=0.002). deformities ear external of identification overall the in better significantly There residents. Pediatric to compared as (p<0.001) deformities ear external of identification the in better significantly performed type on ear deformity identification. were no significant interaction effects between level of training and specialty mities encountered in the clinical setting. Results: Responses from 105 residents were analyzed. Senior residents (PGY 3+) performed significantly better correctly identify Results: Responses from 105 residents were analyzed. Senior residents (PGY Methods: A Qualtrics survey was distributed via email to all pertinent residency programs in the United States. The survey captured survey The States. United the in programs residency pertinent all to email via distributed was survey Qualtrics A Methods: specialty type Pediatrics, (Otolaryngology, and Plastic Surgery) and level of training (divided by PGY 1-2 and PGY 3+). The as- sessment asked residents to identify ten Question clinically Anotia, relevant Stahl Polyotia, external Ear, Lop ear Ear, deformities: the examine to utilized were tests Chi-squared Tubercle. Darwin and 3, Grade Microtia Ear, Mozart Ear, Shell Cryptotia, Ear, Mark association between level of training/specialty type to examine performance group on performance individual on survey To items. were used. ANOVA a t-test and factorial overall mean scores of the external ear deformity survey, Objective: To analyze Objective: a To potential association between resident level of training/specialty type and the correct identification of ex- ternal ear deformities. Kaylee B. Schrader, BS; Joshua C. Demke, MD; Rahul M. Varman, MD; Callie L. Fort, MS; Mhd Hasan Almekdash, PhD; Hannah PhD; Almekdash, Hasan Mhd MS; Fort, L. Callie MD; Varman, M. Rahul MD; Demke, C. Joshua BS; Schrader, B. Kaylee A. Daniel, MDA Ability to Identify External Ear Deformities Based on Year and Specialty of Medical Training Based on Year Ability to Identify External Ear Deformities MS1-2 SCHRADER, KAYLEE School: School of Medicine Our preliminary studies indicate, reduced mitochondrial biogenesis and fusion proteins and increased mitochondrial division pro- Mdivi1 with treatment upon and cells STHdhQ111 the in diminished were sites contact mitochondria ER The neurons. HD in teins these Takenwere togethersignificantly these increased. findings suggest that Mdivi1 restores the MAMand enhances the expres- cells. HD in role protective a plays Mdivi1 which by pathway new a suggesting thereby neurons, HD in associated proteins of sion Huntington’s disease (HD) Huntington’s is long known to be associated with defective bioenergetics, axonal transport and abnormal mitochon obtained were cells The neurons. STHdhQ111 HD mutant homozygous and STHdhQ7 HD type wild both used we this, achieve To reported were Mfn2 and VDAC1 Grp75, IP3R3, as such Proteins mice. knock-in (Q111) homozygous HD and (Q7) wild-type from to be involved in the ER-mitochondrial interactions in neurodegenerative diseases. Therefore, and mutant wildtype HD we HD (Q111/111) (Q7/7) used neurons. studied We immunoblotting, co-immunoprecipitation, these co-localization and proteins in the fluorescent the for constructs GFP-Sec61-β and pDsRed2-Mito with transfected also were cells The methods. microscopy confocal labelling of mitochondria and ER. Based on improvement in cell viability and morphology chosen for further analysis. two concentrations of Mdivi1 were *Neha Sawant will be the presenting author *Neha Sawant will drial dynamics and biogenesis. Mitochondria also associate with other cell organelles such as the endoplasmic reticulum (ER) at specialized contact sites (MAM) where the ER releases calcium ions into mitochondria thus maintaining mitochondrial dynamics and bioenergetics. These sites are known to be disrupted in many neurodegenerative disorders. The purpose of our study was to assess the MAM in healthy and disease states and also to assess whether mitochondrial division inhibitor 1 (Mdivi1) rescues the neurons. defective MAM in HD 1. Internal Medicine Department, 2. Pharmacology & Neuroscience Department, 3. Neurology and 4. Public Health Department, 5. Department, Health Public 4. and Neurology 3. Department, Neuroscience & Pharmacology 2. Department, Medicine Internal 1. Speech, Language and Hearing University Tech Sciences Health Departments, Sciences Texas 3601 Center, 4th Street, MS 9424, United States, TX 79430, Lubbock, Neha Sawant1*, Hem- Subodh Bhagavathi Kumar1, Ramasubramanian1, Adi1 Murali Vijayan1, Pradeepkiran and Jangampalli P. achandra Reddy1,2,3,4,5 MS1-2 SAWANT, NEHA SAWANT, MS1-2 disease in Huntington’s contacts ER-mitochondria 1 (Mdivi1) improves division inhibitor Mitochondrial

ABSTRACTS 90 School: SchoolofMedicine oocytes. 5-HT3A engineered these Xenopus of in inhibition expressed bupropion channels on mutations of effect the examine to used were ies andsite-directed mutagenesis to analyze potential binding siteresiduesforbupropion. Two-electrode voltage-clamp recordings domains. Weextracellular and stud- transmembrane docking of used interface the at located is that loop M2M3 the near segments transmembrane M3 and M2 α-helical disorders. Wethe neurological in other disorder,acids several bipolar amino and engineered and irritable bowel syndrome treatments, but the receptor could potentially become a target for the anti-emetics treatment of anxiety, psychosis, by clinically targeted is HT3receptor 5- the Currently, Disease. Parkinson’s and epilepsy,Alzheimer’s, depression, membrane, and intracellular domain. Dysfunction within this superfamily has been linked to neurological disorders such as anxiety, extracellular, trans- into divided is subunit Each pore. channel ion central a around subunits homologous five of up made are nels superfamily, which also includes nicotinic acetylcholine, γ-aminobutyric acid type A (GABAA), and glycine receptors. These chan- propion’s inhibitory capacity with regard to the 5-HT3A receptor. 5-HT3R is a member of the pentameric ligand-gated ion channel bu- on focuses study present The receptors. (5-HT3A) A3 type serotonin and acetylcholine nicotinic like channels ion Cys-loop cation-selective of inhibition as well as reuptake, dopamine and norepinephrine of inhibition include bupropion of effects known Bupropion is an FDA approved medication marketed as an anti-depressant, smoking cessation, and weight loss drug. Presently, the TX, USA. Ctr,Lubbock, TexasMedicine, Sci Hlth of Tech School Univ 3CPMB, USA, TX, Lubbock, TexasMedicine, Cent, Sci Tech Hlth 1Medical Student SummerResearch Program, SchoolofMedicine, Texas Tech UnivHlthSciCtr, Lubbock, TX, USA,2Schoolof Jansen3. Jessica Shepherd1,DubemOnyejegbu1, Antonia Stuebler2,ZackaryGallardo3,ChrisHornback3,Michaela Bupropion inhibitorycapacityregarding 5-HT3A receptors MS1-2 SHEPHERD, JESSICA School: GraduateSchoolofBiomedicalSciences active learningandincreasestudentunderstandinginthefieldofembryology the NBMEwasimprovedcomparedtolastyear’s class. Collectively, thisprojectprovidesinsight intodifferentwaystopromote view. Although thetotalcurrentschoolclassperformanceonin-houseexamswasnotsignificantlydifferent,their on review, studentsperformed35.6%betteronthe5-questionpost-testwhencomparedtopre-testadministeredbeforere the studentsurvey, over 95% ofstudentsstatedthattheactivelearningmethodologywasveryhelpful. Additionally, afterthefinal mance onthein-houseandNBMEexamwithregardstoembryologywascomparedlastyear Board ofMedicalExaminers(NBME)exam. To evaluatetheeffectivenessofthisactivelearningmethod,currentclassperfor a unitreview. Further, aseparatefinalreviewalongwith5-questionpre-testandpost-testwasheldbefore thestudent’s National eye embryology. The resourcesincludedaflashcarddeckusingthe Ankiflashcardprogram,aquestion andsolutionmodule, were createdwithmaterialcoveringpharyngealapparatus,thyroidgland,tongue,larynx,epiglottis,lip,palate,thymus,ear the associatedeffectsonstudentperformanceaswelltheirresponsestoresources. ology. The objectiveofthisprojectistoconverttheEmbryologyFactSheetintoactivestudyresourcesforstudentsanddetermine lum. Currently, TTUHSC utilizesafaculty-createdEmbryologyFactSheet(passivelearning) alongwithlecturestoteachembry Center (TTUHSC),firstyearmedicalstudentsaretaughtembryologyduringtherigorousClinicallyOriented Medical schoolembryologyisadifficultsubjectforstudentstograspandvisualize. Jake Sellers,Dr. BrandtSchneider, Dr. GurvinderKaur Active learningtechniquesandtheireffectsonmedicalstudenteducationofheadneckembryology MS1-2 SELLERS, JAKE . At Texas Tech UniversityHealthSciences To achievethisgoal,threeresources ’s classperformance.Basedon Anatomy curricu , and - - - - 91 ABSTRACTS - . School: School of Medicine Discussion: Clinics have substantial interest in understanding why patients miss appointments, and many efforts have been made to made been have efforts many and appointments, miss patients why understanding in interest substantial have Clinics Discussion: Staff basis. daily a on problem this with deal who staff, clinic from perspectives gathered have studies Few behavior. this understand no reducing for method current effective most the were reminders message text that felt and problem meaningful a as shows no saw no show fee to further reduce no shows. many staff suggested charging shows. However, Findings: Staff who schedule appointments reported that no shows were a significantly bigger problem than those not involved with involved not those than problem bigger significantly a were shows no that reported appointments schedule who Staff Findings: scheduling, and were more likely to report that no 96% shows, shows no substantially for responsible impact most their was who job Asked duties. Staffshows. no ratedof lostrepercussions biggest clinicthe revenueas care and of continuity on impact negative New patient administration. then clinic and staff, office clinic staff, clinical by followed responsible, most as patients ranked staff of type to result in a no show appointments and ED/hospital follow-up were identified as the most likely appointment Methods: A 14-question survey was distributed to all non-physician employees at Texas Tech Physicians. A total of 95 respondents respondents 95 of total A Physicians. Tech Texas at employees non-physician all to distributed was survey 14-question A Methods: about 61% of which reported having direct contact with patient scheduling. completed the survey, Background: Patient no-show rates can range anywhere from 7% to 33% across specialties and institutions. No-shows affect system affect No-shows institutions. and specialties across 33% to 7% from anywhere range can rates no-show Patient Background: efficiency by increasing wait times and decreasing patient satisfaction. Non-adherence to scheduled visits can lead to:has unmanaged appointments missing repeatedly Additionally, care. emergency of use increased and outcomes, health worse conditions, chronic been shown to lead to medication non-adherence, faster disease progression, and treatment failure. This study aims to understand experience of the problem perceive it. clinic staff perspectives on no shows to better understand how those with practical Jessica Solis, MBA; Jeff Dennis, PhD An Interdisciplinary and Multi-Departmental Study of Patient No-Shows An Interdisciplinary MS1-2 SOLIS, JESSICA MS1-2 SOLIS, School: School of Medicine Conclusion: This study showed that instituting coordinator an was additional associated PAP savings with and increased en- PAP sustain to budget annual $40,000 its quadruple to need would clinic the PAPs, Without 2/2017-2/2018. to compared when rollment the inventory of drugs provided through the these Additionally, division programs. of responsibilities improved PAP efficiency of coordinators as enrollment increased. These results demonstrate the significance of expandingPAP utilization when possible of a free clinic. improve the effectiveness and sustainability to Results: From 2/2019-2/2020, PAPs saved The Free Clinic $169,000 and its patients $211,000. Total clinic savings for respiratory, clinic savings for respiratory, Total The Free saved Clinic $169,000 and its patients $211,000. Results: From 2/2019-2/2020, PAPs diabetic, and miscellaneous illnesses were ~$47,000, $118,000, and $4,000, respectively; total additional enrollment was 69 pa- $100,000; total additional enrollment was 24 patients. tients. Savings from 2/2017-2/2018 was Methods: Data collected for this study includes number of approved applications, medication name/strength, medication cost, num- cost, medication name/strength, medication applications, approved of number includes study this for collected Data Methods: and pharmacy the running of cost annual the determine to analyzed were invoices pharmacy In-house received. date and units, of ber wholesale cost for specific medications. Cost savings from 2/2019-2/2020 were calculated as three distinct values: patient, clinic, from 2/2017-2/2018. values were then compared to savings/enrollment These savings. and category illness tions that the clinic cannot afford to continuously provide are enrolled in Patient Assistance Programs (PAPs). PAPs are offered by tions that the clinic cannot afford tocontinuously Assistance provide Programs are (PAPs). enrolled in Patient added was role coordinator PAP additional an 2019, January In medications. free with patients provide to companies pharmaceutical at clinic. The purpose of this study was to coordinator assess positions on the impact the of extent increasing of PAP cost savings, to compare savings to clinic budget. new enrollment, and Background: The Free Clinic at TTUHSC offers free medical care to uninsured adults in Lubbock, TX. Patients who require medica require who Patients TX. Lubbock, in adults uninsured to care medical free offers TTUHSC at Clinic Free The Background: Annie Snitman, BS, Nathan Chow, BS, Fiona Prabhu, MD, Kelly Bennett, MD Fiona Prabhu, MD, BS, BS, Nathan Chow, Annie Snitman, MS1-2 SNITMAN, ANNIE SNITMAN, MS1-2 Analysis The of Cost Savings, Barriers to Implementation and Overall Benefit Staff AssistancePatient of atProgram Increasing a Clinic Free Student-Run

ABSTRACTS 92 School: SchoolofMedicine nutritional value,whichstands tohelpfuturephysiciansbetterunderstandhowSESmay impacttheirpatient’ family and cost both their on based decisions nutritional as making of difficulty well the understand to students as challenged assignment This members. diet their about decisions daily making to comes it when face patients SES low that barriers the know to need also Physicians illness. and disease of risk lowest the at patients put to going are foods what learn and science nutritional in educated properly be need Physicians improvements. make can they how on them counsel to able be and this recognize to sionals profes- healthcare for important is it and patients, SES low for accessible always not are foods healthy and Nutritious Discussion: may notenjoy, andchoosingsomelesshealthymeals. ents, cooking time, or equipment. Other students noted having to make decisions sacrificing taste, choosing meals that kids may or Results: Students foundthat staying under budget required them to pick meals that were simple and do not require a lot of ingredi a familyof4,andaskedtoassesstheirunderstandingsocioeconomic limitationsbeforeandaftertheactivity economic status (SES) impacts patient’s food decisions. Students were given a budget of $30 to shop for a day’s worth of meals for socio- how of understanding better a incorporate to elective medicine culinary the for developed was assignment new a curricula, Methods: After a review of existing U.S. medical school culinary medicine programs and an literature review on culinary medicine health. is relatively new, buthasgreat potential given that it representsanintersection between medicine, nutritional science, and public to and course medicine preparation culinary conditions. The health chronic of variety a for guidelines dietary food to relating knowledge practical provide understand students medical help to aims elective medicine culinary SOM TTUHSC The Background: Collin Telchik M.S.,JeffDennisPh.D Helping medicalstudentsunderstandtheimpactsocioeconomicstatushasonapatient’s dietarychoices MS1-2 TELCHIK, COLLIN School: SchoolofMedicine and Results testing. Chi-square Conclusion: Resultsandconclusionspendingcompletionofstatisticalanalysis.Estimateddate:EarlyMarch, 2020. using examined be will groups among differences data, categorical For assumptions. normality the meet not did data the if alternative non-parametric its or t-test a using examined be will laparoscopic) vs. (open groups among using the mean, median, standard deviation, and frequencies depending on the measurement level. For continuous data, differences statistics descriptive in summarized and analyzed be will Data compared. and extracted be will GT of type and feeds, full to time Within the groups, data regarding operative time, gastrostomy site complications, pain medication usage, time on ventilator post-op, Patients were split into two groups: those that underwent open GT placement and those that underwent laparoscopic GT placement. 3/31/19. and GT4/1/17 undergoingopen between patients placement or laparoscopic NICU of criteria inclusion the on based base Methods: This was requirements. a retrospective chart review in which medication patients were selected from the Covenant pain Children’s less Hospital NICU data and feeds, full to time decreased days, ventilator postoperative of number decreased cations, compli less have will GT laparoscopic undergoing patients WeHypothesis: that techniques. hypothesize placement GT open and tive outcomes as compared to the laparoscopic technique. This study aims to look at distinct variables shared between laparoscopic not all institutions approach GT placement this way. The open surgical technique for GT placement has been associated with nega- but patients, NICU in performed popularly more become have procedures Laparoscopic survival. and growth for needed nutrients Background: Gastrostomy tubes (GT) serve as an alternative option to oral or nasogastric feedings in neonates in order to receive the Seth Swinney, MSII;CelesteHollands,MD TAL INTENSIVECAREUNIT RETROSPECTIVE ANALYSIS OF OPEN AND LAPAROSCOPIC GASTROSTOMY TUBE PLACEMENT OUTCOMES IN NEONA- MS1-2 SWINNEY, SETH s diet. . - - - 93 ABSTRACTS - . Cre rats AAV-EF1a-DIO- injected with 69,593 to right CeA by microdialysis (to activate KOR signal- KOR activate (to microdialysis by CeA right to 69,593 69,593 to right CeA increased the audible and ultrasonic vocalizations, and decreased and vocalizations, ultrasonic and audible the increased CeA right to 69,593 EYFP EYFP were tested to assess the direct role of CRF+ neurons on pain and anxiety-like behaviors. Optogenetic silencing Results: Twenty-five studies (n=2,864) show procalcitonin for pneumonia has an overall sensitivity:specificity: 0.64 0.72 (95% (95% CI: CI: 0.64-0.79),positive 0.53-0.74), likelihood ratio (LR+): 2.3 (95% CI: 1.8-3.0) and negative likelihood ratio (LR-): 0.50 (95% CI: 0.38-0.66), with an area under ROC (AUROC) curve of 0.74 (95% CI: 0.70-0.78). Using a cutoff of 0.5 ng/ml, pro- 0.53 LR-: 1.3-2.2), CI: (95% 1.7 LR+: 0.47-0.72), CI: (95% 0.60 specificity: 0.50-0.82), CI: (95% 0.68 sensitivity: a has calcitonin 0.59 sensitivity: a has procalcitonin ng/ml, 2 of cutoff a Using 0.64-0.72). CI: (95% 0.68 of curve AUROC and 0.34-0.81), CI: (95% (95% CI: 0.40-0.76), specificity: 0.71 (95% CI: 0.58-0.81), LR+: 2.0 (95% CI: 1.3-3.2),LR-: 0.58 (95% CI: 0.36-0.95), AU- and ROC curve of 0.71 (95% CI: 0.67-0.75). Elevated procalcitonin was associated with increased odds of bacterial pneumonia (odds concerns for bias or applicability ratio: 1.78, 95% CI: 1.18-2.38, p<0.001). Quality assessment finds minimal Methods: Major bibliographic databases were searched from inception through September 2019 using including pre-defined“procalcitonin,” “pneumonia” indexand “children”. Meta-analyses terms, of the diagnostic accuracy and odds ratio of procalcitonin used QUADAS-2 was procalcitonin. of cutoffs different for analyses subgroup with along conducted were pneumonia bacterial for to assess the methodologic quality of eligible studies. Objective: Childhood pneumonia is a leading cause of death. Differentiating bacterial pneumonia from non-bacterial respiratory tract infections for timely initiation of aim antibiotics to is life-saving. Procalcitonin to We predict pediatric pneumonia is unclear. evaluate the diagnostic accuracy of procalcitonin for bacterial pneumonia in children. Po-Yang Tsou, MD MPH; Yu-Hsun Wang, MD MPH; Yu-Kun Ma, MD; Shekhar Raj, MD; John Rafael Ma, Yu-Kun MD MPH; Wang, Yu-Hsun MD MPH; Tsou, Po-Yang conjunc in used be procalcitonin recommend we pneumonia, for accuracy diagnostic moderate procalcitonin’s Given Conclusions: MS1-2 TSOU, PO-YANG MS1-2 TSOU, – a Systemic Review and Meta-analysis for Bacterial Pneumonia in Children Accuracy of Procalcitonin Diagnostic School: School of Medicine This study tested the hypothesis that KOR activation is sufficient for pain-related behaviors in CRF-cre rats. Emotional-affective pain responses were determined by measuring the duration of audible and ultrasonic vocalizations evoked by a brief compression of Anxiety-like the behavior knee. was assessed in the elevated plus maze (EPM) and open field test (OFT). Painand anxiety-like U­ of administration stereotaxic after and before tested were behaviors rats under normal behaviors in CRF-cre for KOR and pain-related is sufficient for pain provide direct evidence activation The data condition. School: School of Medicine Patients with functional pain syndromes (FPS) often experience intermittent episodic pain related to “triggers” including Stress-induced stress. activation of KORs has been shown to promote negative effective states, including depression,amyg- (CeA).The amygdala anxietythe of nucleus central the including andpain, to relevant are that regions pain. brain multiple in found are KORs dala is a limbic brain area that plays a key role in emotional hypothesis that in sensitized depression, responses states, and We stress-induced pain. kappa opioid anxiety, receptor (KOR) signaling and in the affective state and disorders including learned fear, functional pain responses. amygdala promotes U­ of Administration cells). ITC and CeA in ing the center duration of OFT . Effect of optogenetic silencing of neurons CRF+ in CeA CRF­ eNqHR3.0­ with yellow light pulses (590 nm) was delivered through a wireless system. Optical silencing in normal rats. vocalizations and anxiety-like behavior of CRF+ CeA neurons decreased tion with other findings for the management and disposition of patients. 1Pharmacol. and Neurosci., Texas Tech. Univ. Hlth. Sci. Ctr., Lubbock, TX, 2Center of Excellence for Translational Neuroscience TX, 2Center Lubbock, of Translational Excellence for Hlth. Sci. Ctr., Univ. Tech. 1Pharmacol. Texas and Neurosci., AZ Tucson, Arizona, of Univ. TX, 3Pharmacol., Lubbock, Sci. Ctr., Hlth. Univ. Tech. Texas Therapeutics, and D. Tidwell1, M. Hein, P. Presto1, E. Navratilava3, F. Porreca3, G. Ji1,2, V. Neugebauer1,2, V. G. Ji1,2, Porreca3, Navratilava3, F. Presto1, E. M. Hein, P. Tidwell1, D. MS1-2 TIDWELL, DALTON TIDWELL, MS1-2 condition rats under normal behaviors in CRF-cre enhances pain in the central amygdala activation receptor Kappa opioid

ABSTRACTS 94 School: GraduateSchoolofBiomedical Sciences food sources. We willalsopromotemoreeducation onpotablewaterandhowtopreventcontamination of drinkingwatersources. and water of contamination waste human reduce to system latrine composting a building in members community aid and teach to project building a latrine achieve to 2020 June in Health Global of Office the with communities the to returning be will Now,we we Lastly,water. contaminated coli. E. with contaminated were and tested neighborhoods the of 25% that determined and foods, trip our during samples water 100 collected healthy systems, disposal trash of lack the of aware were children the demonstrated with a 6th grade class at a school to gauge their knowledge of health and safety in their community. The photos taken and presented photovoice used we Furthermore, communities. their in contamination water of knowledge their and population the of health eral line for the clinic that was also hosted by the TTUHSC during our trip. From the surveys we were able to better understand the gen- in were that patients to surveys Wechange. 100 community out for gave desires also many and grievances revealed which groups focus and interviews informant key performed we Next, system. sewage a and system disposal waste a areas, recreation markets, ing flood in 2017. Additionally during our windshield survey, we gathered that they were lacking several resources including major Pedregal Grande, Pedregal Chica, Campiña, and Narihualá. Initially, we discovered signs of decay in the housing due to a devastat vey, focus groups, key informant interviews, surveys and water testing. The assessment was conducted in four communities in Peru, conducted a community- based needsassessmentthat included community based participatory research suchasawindshieldsur our complete to 2019 of June in Peru to traveled we students, Health Public of Master project. As Experience Practice Applied We Aksha Upadhyay, KelseySprinkles,&SavannahForsyth A Community Assessment inPeru MS1-2 UPADHYAY, AKSHA School: SchoolofMedicine traditional dressings. with Opsitedressingreported the least pain. These results suggestthat Opticell speeds donorsite healing but isnotsuperiortoall patients and dressing, Xeroform with patients in infection no was There fastest. the healed Opticell and Red Scarlet Conclusion: of 30patients.^6 stud- two in 5% and ies.^4,5 The infection rates for Scarlet Red were 0% and 9.5% in two studies.^15,19Xeroform had a 0% infection rate in a sample 40% of rates infection had Opsite respectively.^9,18,23 2.5 and 2.2, 1.34, of scores pain had Opticell and 11.52 days; Tegaderm 14 days^22; xenograft 15.2 days^11; allograft 19 days.^11 On a visual analog scale (VAS), Opsite, 11.48Xeroform, Opsite days; 10.46 Xeroform Opticell days; days; 10.25 Red Scarlet follows: as were dressings the of rates Healing Results: skin, andpigskin–wereobtainedthroughthePubMeddatabase. Tegaderm,cadaveric Opsite, Red, Scarlett Xeroform, - dressings traditional on Data readmission. of cost stay,and of length trol, con- hemostatic infections, site donor complications, site donor to due readmission rate, healing Registry.included collected Data Methods: Patients who underwent split-thickness skin grafts, and on whom Opticell was used, were reviewed from the UMC Burn allograft andxenograft. Red, Scarlet Tegaderm,Xeroform, Opsite, – dressings traditional to compared Opticell of properties the evaluate to aimed study This patient. the for painful importantly, minimally most and cost-effective for, care to easy hemostatic, activity,is antimicrobial possesses exchange, gas allows desiccation, prevents healing, speeds dressing. dressing site site donor donor ideal ideal the The as criteria the satisfies that dressing a be yet is there but dressing site donor different of abundance the to led have medicine in ments Background: Management of a donor site after skin grafting requires the proper donor site dressing for optimum healing. Advance- Nkemjika Uke;JohnGriswold,MD;SimranSingh;GrantSorensen,PhD;EbrahimPayberah;Ilina The IdealDonorSiteDressing: A comparisonoftheChitosanDressing OpticelltoTraditional Dressings MS1-2 UKE,NKEMJIKA Terziyski - - 95 ABSTRACTS - School: Graduate School of Biomedical Sciences During Techthe Universityfirst-yearTexas Health curriculum Sciences at Center School of Medicine (TTUHSCSOM), students begin the year taking Clinically Anatomy Oriented (COA). In order to help prepare students for summative exams, the faculty exams at formative These exam. written practice one and practical practice one unit- per exams formative two release SOM TTUHSC have allowed us to performance predict on students’ summative exams and evaluate their impact on student stress and the overall number the increasing (e.g. exams practical practice the improve to worked we year, This SOM. TTUHSC at environment learning of questions from 60 to 85 to match summative practical exams) in the hopes that they would better predict performance on sum- After analyzing data from units 1 and 2 in mative COA, exams. we discovered that performance on practical formative exams was highly correlated with performance on summative practical exams (p values: 0.0001; r values: 0.65 for Unit 1, 0.66 There for was Unit also 2). a correlation between summative exam performance and the NBME (p value: 0.0001, r values: 0.704 for Unit 1, 0.738 for Unit 2). Upon updating the practice practical exams this we year, saw an increase in correlation between formative and percep- summative practical exams in comparison to last year (r values: 0.48 (2018-19) and 0.62 (2019-20)). In addition, students’ 5=ex- unfavorable, (1=extremely 4.28 of average an With scale. Likert 5-point a using evaluated was assessments formative of tion the evaluate to distributed be will scale Likert 5-point Another response. student positive a indicate results these favorable), tremely exam summative and exams formative between relationship this Understanding levels. stress students’ on exams formative of effect student stress levels. performance can help medical educators to identify at-risk students and evaluate Bridget Vories, Megh Gore, Brandt Schneider,PhD, Gurvinder Kaur, PhD Gurvinder Kaur, Megh Gore, Brandt Schneider,PhD, Vories, Bridget MS1-2 VORIES, BRIDGET MS1-2 VORIES, Anatomy NBME Performance on Summative Exams and the Student Assessments Predict Practice Makes Perfect: Do Formative The TTRC data for years 2013-2019 were compiled in order to examine its progression and efficacy in providing telehealth tech School: School of Medicine In our research, we aimed to look at the history and progression of the TexLa Telehealth Resource Center (TTRC), a program funded program a (TTRC), Center Resource Telehealth TexLa the of progression and history the at look to aimed we research, our In Texas covering (TRC) Center Resource Telehealth regional a as serve to 2012 in Administration Services and Resources Health by Tech Texas the within located Division (InHT) Technology Healthcare Innovative the by administered is TTRC The Louisiana. and Health Sciences Center’s Marie F. Hall Institute for Rural and Community Health. The TTRC is a collaborative project between Division. State University Health Care Services Health Sciences Center and Louisiana Tech Texas nical assistance and resources to new and existing telehealth programs in Texas and Louisiana as well as provide applications. TTRC has Based consistently on met our its evaluation it was determined that services Telehealth referrals for information of to all for both potential and current users of telemedicine. objectives and has been a beneficial resource Telemedicine refers to the use of technology to deliver clinical diagnoses to patients who are in a separate setting from the physician physician the from setting separate a in are who patients to diagnoses clinical deliver to technology of use the to refers Telemedicine This healthcare by helps enhance technology and healthcare that from remote sites, patient monitoring virtual visits, providing (1). compared when outcomes positive comparable has telemedicine that shown has evidence Recent manner. mobile a in given be can former the scope; of breadth its to due telehealth from differs Telemedicine (2). care medical providing of methods traditional the to focuses specifically on providing remote clinical services whereas the latter can also offer remote nonclinical services. Although relatively new concepts in healthcare, both telemedicine and telehealth have begun to spread throughout the United States as sys- (3). been unable to access healthcare care to a population that has historically tems to provide medical Diana Vo and Catherine Hudson and Catherine Vo Diana MS1-2 VO, DIANA VO, MS1-2 Center (TTRC) Resource Telehealth the Impact of the TexLa Assessing

ABSTRACTS 96 School: School ofMedicine strains areinherentlymulti-drug-resistant. environmental that indicating isolates, patient and environmental in resistance of levels similar were there Surprisingly, method. to have traveled between units. We also determined the antimicrobial resistance profiles of the isolates using the microbroth dilution mental and patient isolate being closelyrelated. Most related environmental isolates weremappedtothesameunit, butsomeappear was sequence similarity within the environmental and patient isolate subpopulations, there was only one (1/16) case of an environ- 275 (3), and ST 3142/2556 (3), with 25 being found in environmental isolates across all units, and 7 in patient wounds. While there ST(6), ST179 (5), ST298 (5), ST253 (7), ST309 (3), ST446 were types sequence predominant genes. The housekeeping seven genome speciation pipelines. Multi-locus with sequence analysis be typing upon PA was to used confirmed to were characterize 54 PAthese, Of strains patients). by from comparing 16 them and to environment sequences from hospital the from (94 isolates 110 MICU, and East Tower, and compared them to patient isolates from the same units. We used whole genome sequencing to compare environmental reservoirs for PA are sink drains. We isolated PAcommon most the that from determined was approximately it Previously half strains. of environmental than all resistant sink antibiotic more drains were strains tested patient in if 4. the BICU, SICU, strains remained in the hospital environment over long periods of time; 3. if environmental strains were the same as patient strains; same the if 2. environment; hospital the distinct in many PA strains or few were there if 1. determine: to wanted Specifically, we dination with UMC infection control, we collected PA strains from the hospital environment and compared them to patient isolates. Pseudomonas aeruginosa (PA) is responsible for a variety of nosocomial infections in many hospitals throughout the world. In coor Health UMC Control, System; 3^Schoolof Veterinary& Medicine, TTU Prevention 2^Infection TTUHSC; Excellence, Research of Center Burn and Surgery of 1^Department Bugarel^3, GuyLoneragan^3,KendraRumbaugh^1 Yates^2,Marie Renae Choate^1, Lauren Cueva^1, Angel Fell^1, Cody Schneider^1, Rebecca Fleming^1, Wakil^1,Derek Anisa Sources andgenomicsimilarityofPseudomonasaeruginosainthehospitalenvironment MS1-2 WAKIL, ANISA School: GraduateSchoolofBiomedicalSciences to anincreaseinperceivedpreparednessandUSMLEexamscores. translates addition this whether investigate should studies Future resource. supplemental problems-based a of creation the for nale tion than other sections on the USMLE Step 1 exam, and the majority would use a university-provided resource, providing a ratio Discussion - As hypothesized, medical students felt they were significantly less prepared for the biostatistics and epidemiology sec- mores: 92.06%;Juniors/Seniors:98.18%). (Sopho- explanations with questions practice including recommended often most and resource biostatistics/epidemiology a use(d) to moderately prepared” on other sections. 100% of sophomores and 67.07% of juniors and seniors indicated they would/would’ve students felt on (p<.0001); average sections “least to by a little significantly prepared” differed by the university university on the the exam’sby preparedness biostatistics section, perceived students’as that compared with suggests “somewhat Evidence - Results man testwasconducted. components for a biostatistics and epidemiology resource. To examine if perceived preparedness between subjects differed, a Fried- recommended and of usage their sections. predicted and exam All various for university Juniors the by preparedness perceived exam. ranked seniors 1 Step (USMLE) Exam Licensing Medical States United the of status completion their by grouped were and Methods - 145 medical students self-reported measures (Sophomore: n=63, 43.45%; Junior: n=51, 35.17%; Senior: n=31, 21.38%) university-provided resourceandstudents’ preferenceforitsstructure. a use would students if discern must we subject, this in proficiency Toimprove 1990s. the since much varied not has curriculum and literature analyze practice evidence-based medicine. Yetcritically this area is regarded to as difficult to teach, leaving many feeling inadequately prepared, as the epidemiology and biostatistics in foundation strong a require students Medical - Introduction Rachel G. Wagstaff, DanielR. Webster Strengthening BiostatisticsandEpidemiologyPreparation withProblem-Based LearninginMedicalEducation MS1-2 WAGSTAFF, RACHEL - - 97 ABSTRACTS - School: School of Medicine manent brain damage or even fatality. The purpose of this study is to expose the prevalence of mild traumatic brain injuries among injuries brain traumatic mild of prevalence the expose to is study this of purpose The fatality. even or damage brain manent high school football players and to explore the possibility of implementing eye as tracking performance an objective way to assess Texas. Lubbock, in School High Frenship at athletes school high surveyed first study multi-part This concussion. potential of cases Student athletes filled out a baseline concussion then survey, assessed their eye tracking performance via the EyeGuide Focus, a mild of concern is there when season, sports the During shape. 8 figure continuous, a tracking visually involves that test 10-second TBI during the game, the athlete will be re-assessed with the Eye Guide Focus. This test will be compared to their baseline score to determine if there is a decline in eye tracking performance, which raises concern for The a survey concussion examined injury. respond- 306 the Among season. sports the during concussion a with diagnosed were whom of (11.6%) 97 athletes, school high 836 ing high school football players, 47 (15.4%) were diagnosed with a concussion by a physician. those to Respondents compared when who concussion non-diagnosed started one least playing at had have to likely more times 2.549 were younger or 5 age at sports who began playing at age 6 or older (x^2=12.374, the p<0.001). With establishment of a baseline EyeGuide Focus score youth athletes, the goal of this study is to implement eye tracking performance as a mainstream form of quickly and accurately detecting concussions. Current research suggests that mild TBIs cannot always be accurately diagnosed via routine neurological examination. A lack of an objective method to assess concussions on the field raises concern for second-impact syndrome (SIS), which can lead to per Brandon Wei, Benedicto Baronia, MD, Jeannie Lee, MD Wei, Brandon MS1-2 WEI, BRANDON - Associ Impairment Neurocognitive to Measure Tool Concussion Management a 10-second Focus®, of EyeGuide Study Prospective Brain Injury ated with Mild Traumatic School: School of Medicine Apparently, growth of Apparently, the TZ causes increased fibrosis of the PZ, making the capsule and thicker, causing atrophy and fibrosis of glandular cells. In very prostate large (>90cc), the entire PZ appears to be transformed into fibrotic capsule, leaving only a few atrophic glands behind. It appears that BPH is protective against PCa and may explain the inverse correlation between BPH and PCa well-documented in literature. We saw a We high positive correlation between the prostate volume and average capsule width (r=0.84, p<0.001) and a high nega- tive correlation between prostate volume and average glandular density (r=-0.74, p< 0.001). In a multiple regression associated significantly be to analysis, found were width capsule average and density, capsule average only model, our in variables all of out with prostate volume The when multiple tested regression individually. model statistically significantly predicted prostate volume < (p prediction the to significantly statistically added width capsule average Only 0.69). R2= adj. 0.001, < p 21.63, = (F(2,17) 0.05). 20 radical prostatectomy cases with different prostate sizes were analyzed using ImageJ, a Java-based open-source image process- PZ the of density glandular of measurement accurate allowed software the within processing intensity pixel Glandular software. ing capsule thickness. allowed direct measurement of the prostate region. Pixel calibration to millimeters within the equatorial It is well-discussed in the literature, prostate the an within inverse (TZ) zone correlation transitional the between of growth size the that of postulate the studies Recent prostate phenomenon. clinical and this explain incidence to of known PCa. However, little is is affecting the peripheral zone (PZ), where 80% of all PCa originates. This study performedmalignancy. this of development of understanding histo-anatomicalbetter for implications possible with density/distribution gland of measurements comparisons and Weaver PW, Smith LA, De Riese WT De Riese Smith LA, PW, Weaver MS1-2 WEAVER, PRESTON WEAVER, MS1-2 Cancer Size in Prostate Based on Prostate in Peripheral Zone of Changes Possible Implications

ABSTRACTS 98 School: SchoolofMedicine should focusonincreasingthe numberofmultiplechoicequestionscompletedandunique students Specifically, medical score. higher a with associated strongly are which factors modifiable several also are there mance, perfor 1 Step USMLE of predictors are grades MCATpreclinical while and that gender suggests score, review Our Conclusions: in preclinicalcourses. study days was associated with increased performance for average achieving students but not for students who received straight As score. 1 Additionally, of Step number higher increased a with associated were seen flashcards Firecracker unique nor courses tory of multiple choice questions completed and number of unique Anki cards seen. Interestingly, neither utilizing commercial prepara- number force, motivating a as anxiety using courses, preclinical completing of months two within 1 Step USMLE taking include factors Modifiable scores. NBME/CBSE and grades preclinical MCAT gender, score, include factors Unmodifiable factors. able modifi- and unmodifiable into divided articles be can from score 1 Step Analysis USMLE articles. of predictors that 30 demonstrated criteria to inclusion the meeting down narrowed then were which articles 275 yielded search literature initial Our Results: the UnitedStateswereexcluded. 2019), with the most recent article published on May 22, 2019. Studies that did not focus on Step 1 outcome or medical students in (2005- years 15 last the within published articles included search The “predictors.” and “success” “score”, “Step-1”, “USMLE”, were used words key The ERIC. and Scopus WebScience, PubMed, of on search literature systematic Wea Methods: conducted possible score.Inthisreview, weattemptto identifywhichfactorscanpredictperformanceonUSMLEStep1. highest the attain to strive students medical Thus, competitiveness. applicant’s residency a determining in factor important most the as 1 Step (USMLE) Examination License Medical States United the ranked have directors program Residency Introduction: Winnie Wu, Sheila Chandrahas,KatyGarcia,Dr. Yasin Ibrahim,Dr. MarinaChavez Predictors ofUSMLEStep1Score MS1-2 WU, WINNIE School: SchoolofMedicine be takentoavoidlife-threatingcomplicationssuchas ACS. spread. RSHcanbetreatedwithconservativemeasuresbutforpatientswhocontinuetobleed,moreaggressiveshould tend tooccurbelowthearcuatelinebecausethereisanabsenceofposteriorrectussheathwhichenableshematomas RSH isararecomplicationthatcanoccurduetotrauma,coagulopathy Kyle Drinnon,BS,Ellen Wilson, SeanSimpson,MD,CatherineRonaghan,RobynRichmond,MD Rectus SheathHematoma,arare surgical emergency MS1-2 WILSON, ELLEN , obesity, musclestrainsandpregnancy. Larger hematomas Anki cardsseen. - 99 ABSTRACTS - School: School of Medicine The main goal of psychiatric evaluation of Given asylum the seekers shortage is of to comment on the credibility. asylum seeker’s interview Telephonic feasible. be not may evaluation person in evaluation, of type particular this in trained providers health mental has been occasionally utilized to fill this The void. validity of such evaluations in assessing credibility has not yet been studied. In be can deception of Cues Objective cues. language body or facial to access no have evaluators the interviews, telephonic of case the telephone via evaluated client a of case a present will We language. body and expressions, facial narrative, clients’ from appreciated that was deemed credible and eventually released to pursue Assessment asylum of in Credibility the was US. based solely on cues obtained from client’s narratives and their style of interaction with the will We evaluator. highlight the findings from the client’s speech that supported credibility in the case and discuss the challenges of assessing asylum seeker’s credibility via telephonic in- evaluators psychiatric but challenges, major despite method valid a considered be can credibility of evaluation Telephonic terview. of secondary gains and deception. should be aware of the limitations of telephonic evaluations given the high possibility Yasin Ibrahim*, Samuel Yang*, Chuck Giles, Regina Baronia, Marina Chavez Yang*, Ibrahim*, Samuel Yasin Validity of Psychiatric Evaluation of Asylum Seekers through Telephone Asylum Seekers through of Psychiatric Evaluation of Validity MS1-2 YANG, SAMUEL MS1-2 YANG, School: School of Medicine Results: Clinical success, safety based on adverse events, and quality of life improvement criteria were evaluated and compared to devices. treatment (PTNS) stimulation nerve tibial percutaneous non-implantable older, and devices (SNS) stimulation nerve sacral appears it available, currently is data up follow months 6 to up only and treated been have participants of number limited a Although upon implanta response rates, are less invasive promising clinical nerve have the tibial stimulating devices new implantable the that Conclusion: Practicing urologists should be aware of this new treatment option when counseling their patients regarding treatment for OAB. Patients and methods: A focused literature search for the years 2015 through 2019 was conducted on PubMed/Medline for the terms: the for PubMed/Medline on conducted was 2019 through 2015 years the for search literature focused A methods: and Patients “new AND techniques” AND “neuromodulation” “tibial nerve AND stimulation” “overactive bladder”. limited We our search to follow-up of at least 3 months. for the last five years and with patient publications in English, PTNS devices. compared to the older non-implantable expensive, and less of a burden on patients tion than SNS, less Purpose: The purpose of this review is to offer an update for medical providers practicing general urology and urogynecology in in patients with OAB. technologies for neuromodulation evolving and new promising Justine Yamashiro Justine MS1-2 YAMASHIRO, JUSTINE YAMASHIRO, MS1-2 - neuromodula established to comparison in results clinical published of review devices: stimulation nerve tibial implantable New tion devices

ABSTRACTS 100 School: School ofMedicine be consideredin patientswithsevereillness intheneonatalperiod. leading to its lack of diagnosis due to improper follow up on newborn screening techniques. Furthermore, evaluation of IEMs must was determined that the second newborn screening was never completed. In our patient, a treatable IEM became a medical mystery both tyrosinemia and phenylketonuria but in our patient, such disorders could not be established. Upon obtaining outside records, it of 4-hydroxyphenylacetic acid and 4-hydroxyphenyllactic acid. Abnormal amounts of both compounds are non-specific findings in outpatient follow-up. Results of the urine organic acids received after the final discharge revealed the presence of elevated amounts disorder.oxidation acid fatty sible dischargedwas with He resolved. acidosis initial the Withhydration, and formula in change the obtained. were acids Apos- of concern to due formula in change a recommended who consulted was specialist metabolic pediatric amino serum and acids organic urine negative; UAwas elevated. were procalcitonin and protein C-reactive levels. ammonia lactate and normal with acidosis metabolic anion-gap normal showed admission. Workup first the since loss weight 360-gram a and decreased oral intake and activity. At the time of re-admission, the patient appeared lethargic with significant abdominal distension significantly for discharge initial after days two re-presented patient The home. discharged was he acidosis; metabolic the of tion was It resolu- with improvement unremarkable. demonstrated He obstipation. to patient’ssecondary the likely that was concluded distension abdominal were which studies, gastrointestinal numerous for underwent facility patient our the to admission, transferred Upon and evaluation. antibiotics further empiric with treated was He acidosis. metabolic severe and distension abdominal have to found was and feed each with emesis of history 2-day a with hospital outside an to presented initially male A5-week-old Udhaya Aelety, Abirami Rajasegaran Atypical NewbornPresentation ofanInbornError ofMetabolism MS3-4 AELETY, UDHAYA School: SchoolofMedicine Flags forSex Trafficking and(b)Sex TraffickingProtocolformedicalpersonneltofollowwhentheyareinteractingwithvictims. accessible resource for managing the care of ST victims in a medical setting. The badge insert is double-sided and includes (a) Red A final deliverable of this project is the creation of an ID badge insert designed for medical students and residents to have an easily victims in the medical field would increase the knowledge and comfort around following steps to appropriately care for ST victims. STmanaging on presentation introductory short a that suggest results post-survey and pre setting. The medical a in STvictims for care best to follow to steps appropriate the of knowledge the evaluating on The Yearfocused victims. STmethods for 2 available in Lubbock is known, more targeted education is needed to improve both the knowledge and comfort around utilizing the resources sex-trafficking of knowledge general while that revealed data post-survey and Pre victims. ST assist to available resources the ing medical setting. The Year 1 methods focused on assessing the knowledge among medical students, residents, and physicians regard- the ST resources available in Lubbock and (2) to improve the comfort of medical students and residents of in handling residents’STunderstanding students’victims and in a medical in found gap knowledge the bridge to (1) is project this of goal The resources. adequate and care focused with them provide to and victim ST a identify to student medical and resident physician, a of part the on awareness takes it Often Hospitals. Covenant and UMC at care offered are that patients many the among for are resources who victims and ST continuity providing in role important an plays community medical The in Texas. city trafficked most second the is Currently, Lubbock Lubbock. in in especially issue Texas, important more increasingly an become has (ST) trafficking Sex Frances KellermanHanson,ShelbyBuckner, Vivian Yim, andNitishMittal Victims intheMedicalSetting Identifying RedFlagsforSexTrafficking: AGuideforMedicalStudentsandResidentstoBetterCare forwithSex Trafficking MS1-2 YIM,VIVIAN MEDICAL STUDENTSYEARS3-4 101

ABSTRACTS School: School of Medicine | Campus: Lubbock Appendicitis is a commonly encountered diagnosis diagnosis is in critical acute and Timely abdomen requires presentation. a high a deep index knowledge of unclear base suspicion. etiology, of Despite the it’s possible causes that can lead to appendicitis is cru- appendicitis. of suggestive unlikely sometimes symptoms with presenting patients of management surgical proper providing in cial blockage of the Typically, appendiceal lumen by stool, parasites, or even growths causes appendicitis; however, other causes can also factor in causing an inflammation of the appendix such as GI tract infection, IBD, and, abdominal infrequently, trauma [2]. The pathophysiology of traumatic appendicitis is mainly described by the obstruction of the appendiceal lumen that likely results from shearing forces, compressive forces, crush injury mesenteric or indirectly obstructive ileocecal hematoma or locally enlarged the in stool of impaction induce also can Trauma [2]. appendix the as such structures hollow nearby the compress that nodes lymph ap- non-traumatic the of that mirrors usually appendicitis traumatic of Presentation [2]. appendicitis to leading hence and appendix present we report, case this in However, [1,2]. anorexia and nausea, peritonitis, of signs pain, RLQ fever, includes which pendicitis, a case of acute abdomen which history the and patient’s physical exam were not suggestive of acute appendicitis; hence requiring further imaging and an exploratory laparoscopy, eventually leading have to believed was and to collision vehicle motor a in a involved being after pain laparoscopic abdominal with presented male, appendectomy. 16-year-old healthy The patient, an otherwise in this report. developed traumatic appendicitis based on his history and physical exam as described 1 TTUHSC at Lubbock, School of Medicine | * denotes senior author TTUHSC at Lubbock, 1 Abirami Rajasegaran, MSIII1; Sara Dogom, MSIII1; Thomas Wyatt, DO1; Dayton Wong, MD1; John Haley, MD1*; Catherine Ronaghan, MD1* Case Report: Traumatic Appendicitis - An Unclear Etiology - Appendicitis Case Report: Traumatic MS3-4 AL DOGOM, SARA School: School of Medicine Fat-soluble vitamin deficiencies, in particular vitamin D deficiency, are commonly seen in patients with chronic liver disease such as such disease liver chronic with patients in seen commonly are deficiency, D vitamin particular in deficiencies, vitamin Fat-soluble presented who disease Celiac and PBC with female 64-year-old a of case rare a present we Hereby, (PBC). cirrhosis biliary primary demonstrated results Laboratory blindness. night worsening and fatigue, overall diarrhea, loss, weight of complaints with ED the to of levels increasing prescribed was Patient K. vitamin and D vitamin of levels normal having despite deficiency A vitamin isolated believe that supplements, which improved her levels. A We night blindness although she A vitamin continued having low vitamin patients with chronic liver disease. should be closely monitored in vision and dark adaptation Ahnood, E. MS3, Tangella, N. MS3, Payne, D. DO N. MS3, Payne, Tangella, MS3, Ahnood, E. MS3-4 AHNOOD, ELMIRA AHNOOD, MS3-4 Biliary Cirrhosis With Primary Patient Deficiency in a A Case of Isolated Vitamin Rare A

ABSTRACTS 102 School: School ofMedicine post-operative metricsofcomplication butmuchmorecosteffectivewithoutcausingincreases inoperativetime. several across technique stapler than worse no least very the at ELis that WeEL technique. demonstrate in also LOS decreased a than stapler although not analyzed but prices differences if very well-known fromcost thecheaper market.a Inwith additionassociated toadditionally was thatand ourstump findingappendiceal suggests the of ligation safe and adequate provides it and surgeons of armamentarium the in tool another is ELcenter. our at 2017 since emphasized been has technique EL of utilization Increased ST, p=0.006).No statisticaldifferencewasnotedin30-dayMorbidityandpost-opcomplications. vs1.01 days, =0.76 (mean EL difference a significant showed LOS mean the time, intraoperative in found was difference nificant males ST: In (n=102). females sig- statistically no (n=117), While demographics. in groups 2 the males between found were differences statistical No (n=253). females (n=365), EL: In examined. were criteria inclusion our fit patients 837 of number total A T-test or Fisher’s Exacttestwereappropriate.StatisticalanalysiswasperformedusingR. surgery.surgicalusing obstruction as bowel such and complications post-operative ileus, formation, 30-day abscess infection, site stay,of hospital duration of Length to, limited not were but included techniques STEL and the between compared ter.Outcomes Cen- University a at appendectomy laparoscopic underwent who patients of review chart by study cohort retrospective a is This superior tooneanother. is technique one if see to them between outcomes in differences at look to was objective Our these. between complications erative postop- examined have studies few base,however appendiceal the ligating of methods popular most the are staplers or harmonics and Endoloops appendicitis. acute for care of standard the become has appendectomy laparoscopic decades, several past the Over MD Vincent Athas MD, Adel Alhaj Saleh MD, Zayne Bilal MS, Brittany Grudzielanek MS, Kerrick Akinola MD, Sharmila Dissanaike Appendicitis Acute of Management Laparoscopic the in Faculty Surgery General Among Methods Completion Two of Outcomes Comparing MS3-4 ANDERSON, BRITTANY School: SchoolofMedicine reported intheliteratureofthistumortypescrumanoctogenarian. CONCLUSION: Weregion. sacral the in formation tumor GB of case rare a reporting Toare be to case first is this knowledge, our paroxysmal pain,delayingdiagnosis. the masking probably was ulcer atypical. the patient Also 80-year-old our making 20-40, ages in presents tumor GB presentation. rare very a sacrum the makes extremities, in found are tumor these of majority the that fact variant. The multiple as exist minority a solitary,but are tumors the of 90% bone. or tissues soft involve may that body GB the of tumor a is tumor GB DISCUSSION: showed thatthetumorwaspositiveforCD34andSMA whichconfirmedthepresentationofaglomustumor withfreemargins. of tumor cells present within the extensive ulceration and necroinflammatory changes. Immunophenotypic and morphologic feature sent for both culture and pathology to rule out osteomyelitis. Pathology report of the excised Sacral decubitus ulcer showed islands were biopsies sacrum and tissue Soft sacrum. the to down extended and excised was wound superficial the where debridement al change and was found to have a sacral ulcer on admission. Wound was a stage IV decubitus ulcer. The patient was sent for excision CASE: An 85-year-old female nursing home resident with extensive medical history present to the hospital for a cardiac pacemaker The objectiveofthispresentationistodescribearareGBtumorfoundininfectedsacraldecubitusulcer papule withparoxysmalexcruciatingpainoutofproportionsize,andcoldsensitivity excessive cold like in the dermis to of fingerssubject or toes.areas 70% ofin GB tumorsconcentrates occurGB by age 30. GBtissues. tumor presentconnective asof purple orcapsule pink vascular a by surrounded shunts arteriovenous are which (GB), bodies glomus from arise They tumors. tissue soft of 2% than less comprising neoplasms benign are tumors Glomus INTRODUCTION: Jonathan UmeloMS3,Sara Alhaj MS3,MuhammadNazimMDFACS, Hassan Ahmed MD Rare GlomusTumor inSacralDecubitusUlcer MS3-4 ALHAJ, SARA . . - 103

ABSTRACTS School: School of Medicine Introduction: Acute limb ischemia may be life-threatening and even lead to limb loss. It is one of the most common causes of lower of causes common most the of one is It loss. limb to lead even and life-threatening be may ischemia limb Acute Introduction: extremity amputation, affecting approximately 1.5 persons per 10,000 per year.1 Immediate diagnosis and treatment are crucial. Generally, an endovascular approach should be taken for acute limb ischemia. The procedure involves surgical common femoral exposure or popliteal arteries then of extraction or aspiration of the the thrombus. Here, we present a patient with bilateral acute lower limb ischemia who underwent lower extremity angiogram and intervention via right radial arterial access due to limitations restricting access American via man the with common a femoral African An and 85 popliteal arteries.: year Case old Presentation: with institution our to presented radiation, s/p ago years 10 cancer prostate and hypertrophy, prostate benign hypertension, of history ARI, thrombus, LV intracavitary LVEF, low with associated ischemia, limb of evidence Doppler ischemia. limb lower acute bilateral and lactic acidosis indicated for a lower extremity angiogram and aspiration thrombectomy. Interventional Procedure: The right radial artery was accessed via ultrasound guided modified Seldinger technique and a 6-Fr slender radial sheath was placed. Post A duplex procedure the right popliteal artery remained occluded but had improved flow with significant residual thrombus burden. examination of the lower extremities was ordered for the next morning to assess if thrombi dissolved without intervention. Patient was continued on heparin drip, aspirin, clopidogrel, and statin Discussion: therapy. Early intervention for acute limb ischemia is critical to saving both The life radial and approach limb. shows viable solutions when technical or pathological complications pre- vent routine approaches from being made. PI: Mohammad Ansari, MD PI: Mohammad Simran Singh, BS, MBA; Jeanie Lee, MD; Tim Dixon, BS, MSIV, Avantika Banerjee, BS, MSIV Avantika Dixon, BS, MSIV, Tim Simran Singh, BS, MBA; Jeanie Lee, MD; Radial approach for lower extremity thrombectomy for lower extremity Radial approach MS3-4 BANERJEE, AVANTIKA MS3-4 BANERJEE, School: School of Medicine Discussion: Some Lactobacillus spp. can survive and protect against harmful pathogens in patients with recurrent fungal vaginitis. fungal recurrent with patients in pathogens harmful against protect and survive can spp. Lactobacillus Some Discussion: species. fungal and spp. Lactobacillus particular confirm to required are methods identification precise other and method culture Lab Results: 17 swabs confirmed with fungal infections by clinical finding, but out of 17 swabs only 13 (approx. 77%) confirmed with and findings clinical between spp. in Lactobacillus difference significant no was There method. culture lab by spp. Candida specific lab culture method. Study design: Fungal communities from vaginal swabs were classified by lab culture method (Sabouraud dextrose agar and my- cobiotic agar). In clinics, diagnosis of fungal infections of vaginal swabs is accomplished using wet mounts/potassium hydroxide and species Lactobacillus specific detect to swabs vaginal on out carried was PCR real-time A patients. symptomatic in preparation used to confirm specific fungal species. culture method was Introduction: Introduction: Lactobacillus species play a vital role in the vagina, inhibiting the growth of pro- that pathogenic biofilm a few bacteria. produce spp. Very studies Lactobacillus Some vaginitis. fungal recurrent with spp. Lactobacillus of relationship the examined discharge, in resulting Candida, species, fungal the by infection is vaginitis of cause common A proliferation. microbe against tects redness, and pain. For Candida to become pathogenic, the vaginal epithelium, microbiome, or the specific microbes need to be al- and methods culture lab vs findings clinical by identified communities fungal the compare to are study this of objectives The tered. with recurrent fungal vaginitis. of Lactobacillus spp. and patients to examine the relationship R. Arispe, MS3, K. Gandhi, PhD, P. Gutierrez, MS, S. Gygax, PhD, and G. Ventolini, MD, FACOG, FAAFP MD, FACOG, Ventolini, G. S. Gygax, PhD, and Gutierrez, MS, Gandhi, PhD, P. Arispe, MS3, K. R. MS3-4 ARISPE, RYAN ARISPE, MS3-4 Vaginitis Fungal and Recurrent Lactobacilli Vaginal

ABSTRACTS 104 School: School ofMedicine in aggressivecancerslikesmall cellcarcinoma. control durable long-term a synergy produce the can therapy and immune radiation with of therapy effect radiation abscopal of the that emphasize to case field. this radiation present the We of outside sites disease in regression tumor immune-mediated in results radiation localized whereby effect abscopal the as known phenomenon a induce can turn in this and antigens, tumor of release the facilitating by response immune the prime to vaccine” situ “in an as acts treatment therapy Radiation agents. immune-stimulating localized radiation promotes specific tumor-targeting by the adaptive immune system which can be further augmented by systemic by release antigen Tumor antigens. tumor of expression reducing by surveillance immune evade to ability the have cells Cancer date. till PFS durable with calcification showing disease, of sites active all in also but lesion liver the in only not shown response with given was liver the to radiation and started was Nivolumab lymphadenopathy.with retroperitoneal Immunotherapy and liver with irinotecan on cancer progressive developed Patient irinotecan. line second on started was and metastasis liver proving biopsy new treated with cisplatin and etoposide along with radiation followed by prophylactic brain radiation. Three months later, patient had a initially was cancer, cell small stage limited with male forty-one-year-old a patient, Our agents. immune-stimulating and therapy radiation with treated when months 22 beyond PFS with response durable a maintained patient our where Wecase data. a present historical on based unlikely is response therapy.Durable immune and chemotherapy combination with months 5.2 and inhibitors therapy is less than 6 months at best. The median progression free survival (PFS) is 3.3 months with combined immune check point Small cell lung cancer or high-grade neuroendocrine carcinoma have poor prognoses and expected survival after failing two lines of Sanyukta Bihari,NagaCheedella,MichaelBurke,KavithaDonthireddy of cancer Abscopal effect in solid tumor malignancy and the synergy of radiation therapy and immune therapy with long term durable control MS3-4 BIHARI,SANYUKTA School: SchoolofMedicine viability ofthepregnancy. the maintain and treated be can injuries trauma prenatal complex how of example an as serve would Conclusions: report case This without gestation weeks 23 at complication andwasclearedforvaginaldelivery.be to observed last was She complications. orthopedic without walking is and well recovering is Currently,leg. right the on bearing weight down touch she and leg left the on tolerated as bearing weight discharge,was Upon she had anotherwiseun-complicatedcourseandwasdischarged tohomeonthe7thdayafteradmission. toscopy, vaginal exam, on-table cystogram and fluoroscopy were performed. The following day, a pelvic ORIF was performed. She proc- fixation, external pelvic underwent she which during stabilization initial after surgery to taken was patient The presentation. the between separation. The intervening right sacroiliac tissue joint showed soft 4 mm with of widening injury with tissue an intact soft left sacroiliac a joint. and Afracture, pelvic greenstick binder was rami placed before pubic inferior left a acetabulum, the of air,to roof open and pubis wall symphysis anterior right the the to with extends fracture that fracture buckle acetabular sided left a rami pubic inferior right a acetabulum, right-sided the of roof and wall anterior the to extended that fracture vertical a were: tained sus- injuries The period. menstrual last by gestation weeks six at be to estimated patient trauma a of case Wethe Results: present complicating factors.Pelvicinjurycanpresentadditional,specificproblemsforthepregnantpatient. other or injury tissue soft concomitant with associated when risk higher with patient, non-pregnant a in 32% to up of mortality a patients. Additionally, estimated fetal loss among pregnant trauma patients is 34%. A serious traumatic injury, pelvic fractures carry trauma total of 1.5% up making patients pregnant with death, maternal non-obstetric of cause primary Introduction: Traumathe is Beaman BS Alexsandra P. Rojas BA, Robert Jameson MD, Jayne McCauley MD, Robyn Richmond MD, Catherine Ronaghan MD FAC, Erica A casereport andliterature review: Complextraumaticpelvicringfractures andsofttissueinjuriesinapregnant patient MS3-4 BEAMAN, ERICA 105

ABSTRACTS - This Conclusion: These results suggest that most patients are confident in their ability to access care and believe that pediatricians Conclusion: Results: A total of 45 surveys were included in our analysis. 55% of respondents (n=25) agreed that excessive guilt and feeling total of 45 surveys were included in our analysis. 55% of respondents (n=25) agreed that excessive A Results: than 2 weeks. 26.7% (n=12) were neutral and overwhelmed were not normal signs of parenthood when experienced for greater symptoms of guilt or hopelessness for more than 17.8% (n=8) believed such symptoms were normal. 83.3% (n=42) agreed that doctor (the Pediatrician) should When asked whether they believed their child’s 2 weeks warranted evaluation by a physician. 15.6% (n=7) disagreed. 66.7% (n=30) agreed that screen mothers for PPD, 74.9% (n=31) agreed, 15.6% (n=7) were neutral, and endorsed the ability to reach out to a physician if the Pediatrician should educate them about PPD. 86.7% of respondents (n=39) Pediatrician, 77.8% (n=35) were When asked about their agreeability to seeking help from the they developed PPD symptoms. agreeable, 13.3% (n=6) were neutral, 8.9% (n=4) respondents were not agreeable. Methods: Surveys were administered in Amarillo, Texas at: (i) Northwest Texas Hospital to mothers in the postpartum unit, and Hospital to mothers in the postpartum unit, Texas at: (i) Northwest Texas Amarillo, Methods: Surveys were administered in survey items Ten 2-week well-child visit postpartum. outpatient clinic to mothers presenting for a and Children’s Women’s (ii) the knowledge, attitudes, and empowerment regarding PPD. assessed mothers’ project was designed to assess the efficacy of pre-discharge PPD education. We describe findings regarding attitudes and beliefs We describe findings regarding attitudes and beliefs PPD education. project was designed to assess the efficacy of pre-discharge about PPD symptoms and the role of pediatricians in screening for PPD. Introduction: Peripartum depression (PPD) is a common perinatal complication that may harm both mothers and newborns. Introduction: Peripartum depression (PPD) is a common perinatal complication Avery Bramnik, Avery MSIII; Luke Bacon, MBA, Joel MSIV; Ana Barrett, Leon-Arango, MSIV; Emily MSIV; Nguyen, MSIII; James MSIII Tran, Maternal Attitudes Regarding Postpartum Depression Postpartum Attitudes Regarding Maternal MS3-4 BRAMNIK, AVERY Conclusion: Our study revealed that about 32% of the pediatric hematology referrals could be avoided, because either the labs were labs the either because avoided, be could referrals hematology pediatric the of 32% about that revealed study Our Conclusion: back to normal with therapy or resolved without intervention. Implementing guidelines for PCPs about the most common hemato Results: The most common reasons for referral to Hematology clinic were abnormal Hb and WBC counts. The top three final diag- final three top The counts. WBC and Hb abnormal were clinic Hematology to referral for reasons common most The Results: nosis in decreasing frequency were: (hemolytic, Iron deficiency anemia (IDA), leukopenia or leukocytosis, anemia other than IDA median a had Patients weeks. 8 within referral after hematologist by evaluated were patients the of 95% trait). thalassemia aplastic, of 3 visits to the hematology clinic and 23% of patients only visit. required first one of About visit. time 33% the of at the abnormal referrals not were could findings be laboratory managed the by and/or referral before started been had already therapy the as PCP The cost of unnecessary visits There was to subspecialty no clinic significanttotalled relation$82,888. between the final diagnosis cost that visits The (p<0.05). referrals necessary be to tended miles 100 than longer travelled who Patients referral. for necessity and more than $5,000 were all necessary referrals. Method: One hundred and one pediatric patients who were referred to SWCC at University Medical Center in Lubbock, TX between TX Lubbock, in Center Medical University at SWCC to referred were who patients pediatric one and hundred One Method: study. the in included were tests, coagulation or (CBC) count blood complete abnormal for 2018 30, September and 2015 1, January retrospective A chart review was done. “Necessity” of referrals was determined by evaluation of patient labs prior to referral, lab (PCP) without need for referral. be handled by primary care physician specialist visit, and diagnosis that could values at the initial School: School of Medicine Objective: To evaluate the necessity of pediatric hematology-oncology referrals to Southwest Cancer Center referrals. of health related costs due to unnecessary reasons for referral and determination outcomes include common (SWCC). Primary logic problems such as anemia, neutropenia, thrombocytopenia and coagulation defects can improve Texas the healthcare in West area. Background: Background: It has been shown that one in forty pediatric visits in the US results in referral to specialty care with the top reason appropriate of delivery and diagnosis of delays in results care subspecialty to access Poor treatment. and diagnosis on advice being and healthcare” affordable to “access (2016), UMC at Assessment Health Needs Community the to According patients. to therapies referrals of causes possible Identifying area. Lubbock the for needs health community significant top the of two are “transportation” and costs. time off work or school, travel, could prevent unnecessary Irem Eldem, Peyton Bluhm, Angela Abraham, Chibuzo O’suoji Abraham, Angela Peyton Bluhm, Irem Eldem, MS3-4 BLUHM, PEYTON BLUHM, MS3-4 Texas in West University Hospital a Tertiary Referrals at of Pediatric Hematology Evaluation

ABSTRACTS 106 orbits. Immunochemistry from the biopsy was positive for CD20, bcl-2, Ki-67(~10%) and negative for CD3, CD5, CD10, cyclin D. and conjunctivae the of lymphoma zone marginal extranodal II stage showed tumor orbital bilaterally.left spared the of Abiopsy approximately measured mass left-sided 3.3x2.4x1.2 cm. the The extraocular muscles bilaterally appeared to be extrinsic and from these masses and the optic nerves cm, appeared to be 0.9x2.6x1.2 approximately measured mass right-sided The extension. nal A MRI of the orbit/face/neck showed bilateral enhancing masses within the preseptal fat, with right-sided postseptal and intracoro fleshy, vascular lesionvisibleintherightconjunctiva. denied any impairment of vision. Upon examination, she was found to have mechanical left superior eyelid ptosis and salmon pink, patient The eyes. her both in “knots” of complaints with PCP her to presented female Hispanic Presentation: A63-year-old Case tivae andorbitsthatwaseffectivelytreated. makes up about 1-2% of non-Hodgkin’s lymphoma. We present a rare case of extranodal marginal zone lymphoma of the conjunc and muscles extraocular or eyelid, the of tissues soft gland, lacrimal conjunctiva, the in originates lymphoma Orbital Introduction: rillo, (3)DepartmentofRadiology, Northwest Texas HealthcareSystem TexasProgram, Residency Center Medicine Sciences Tech Ama- Internal Health (2) University Medicine, of School (1)TTUHSC Ruth D’Cunha,NicholasD’CunhaMD Extranodal Marginal ZoneB-cellLymphoma oftheConjunctivaeandOrbits MS3-4 D’CUNHA,RUTH School: SchoolofMedicine ous factorscomprisingpatientsatisfaction,recognizingthatsurveyscoresareimpactedbymorethanproviderperformance alone. health care reimbursement, it is critical to consider the complexity of this subject. Further studies are warranted to explore the vari- of driver important increasingly an literature become has experience current patient nature. As in multifaceted with is satisfaction patient line that indicating in is This type. insurance by affected are scores satisfaction patient that show data Our Conclusions: for allinsurancegroupsexceptbetweencommercialandself-pay(P=.12). (P<.001) significant statistically were order.differences that These in self-pay,Medicaid, insurance, and commercial insurance, government other utilizing those by followed Medicare, with those for highest were scores satisfaction patient mean The Results: mean survey scores were then compared between groups. One-way ANOVA and Tukey HSD tests were used for statistical analysis. five groups according to patient insurance type: Medicare, Medicaid, other government, commercial, and self pay. The differences into classified and in center academic an at System Ganey Press the from collected were surveys satisfaction Self-reported Methods: satisfaction scores. Given the limited exploration into the drivers of patient satisfaction, the present study aims to evaluate the role of insurance type in edge and socio-economic status among others, but these studies never analyzed how each factor specifically affected survey scores. patient’sfactors thataffecta that therearemany givenencounter, any perceptionof medicalknowl- includingwaittimes,previous shown have policy.Studies compensation provider their of part a as survey HCAHPS their of results the uses Medicare example, Introduction: Patient satisfaction is becoming an increasingly important factor affecting reimbursement of healthcare providers. For MD, PhD,MBA Chloe Cooper, BS, Kelly Little, MPH, Rohali Keesari, MPH, PharmD, Mhd Hasan Al-Mekdash, MA, MS, PhD, Cornelia de Riese, THE ASSOCIATION BETWEENINSURANCETYPE AND PATIENT SATISFACTION SCORES MS3-4 COOPER,CHLOE School: SchoolofMedicine signs andsymptomsofPPD.Limitationsthisprojectincludeasmallsamplesizelimiteddiversitypatientdemographics. should playsomeroleinscreeningforPPD.However, manymothersdonotseemtopossessanadequateunderstandingofthe - - 107

ABSTRACTS - - . School: School of Medicine Discussion: Mental Health professionals must utilize PTSD scales especially with patients who are trauma history to not avoid missing this forthcoming diagnosis. It is about important to past educate immigration officials and lawyers about the necessity of order to appropriately present themselves in asylum interviews. needs in accommodating clients’ Case Presentation: Ms. B presents for psychiatric evaluation seeking asylum in the United States after multiple threats on her life in At Honduras. initial evaluation she was diagnosed with depression. On reevaluation, she was found to have panic attacks as a manifestation of post traumatic stress disorder triggered by previous trauma. Recommendations included a anxiolytic medications and the use of pre-written statements upon Patient interview. was unable to convince officer of credible fear and was deported to Honduras. Introduction: Asylum applicants can benefit from psychiatric evaluation which can explain how culture and mental health symptoms health mental and culture how explain can which evaluation psychiatric from benefit can applicants Asylum Introduction: relate to perceived deficits in credibility. Sabrina Deleon, Dr. Regina Baronia, Dr. Rosalinda Jimenez, Dr. Yasin Ibrahim Yasin Dr. Rosalinda Jimenez, Regina Baronia, Dr. Sabrina Deleon, Dr. Deportation of a detained asylum seeker with disabling panic attacks MS3-4 DELEON, SABRINA MS3-4 DELEON, Discussion. A rare, A but Discussion. notable, risk factor for rectus sheath hematomas is direct muscle injury or indirect damage due to forceful Theeffort. contraction patient– hadincluding been defecation found& unconsciousany &Valsalva increased hypotensive on the administra with constipation her of treatment that possible be may It constipation. to secondary event vasovagal a to due commode Case Report: A 76-year-old Case female A in Report: the CCU for cardiac stabilization was found unresponsive & hypotensive on the commode. After returning to consciousness and reporting severe abdominal pain, a CT was ordered and found a large left RSH with active peritoneal hemorrhage anteriorly from the inferior epigastric vessels. Despite an IR guided embolization of the inferior epigastric artery and laparoscopic ligation of the left inferior epigastric artery, a second laparotomy hemorrhagic to secondary failure multiorgan with sedated deeply kept found was Patient bleeding. active continued with necrotic frankly the colon & gallbladder to be chose to withdraw care and patient was pronounced dead following asystole. The family shock. Introduction: Low molecular weight heparin (LMWH) demonstrates comparable efficacy to unfractionated heparin, but is a first- line option for thromboprophylaxis due to decreased risks of major bleeding & heparin-induced thrombocytopenia. this However, artery RSH secondary to enoxaparin injection. paper presents a fatal case of epigastric Ryan Dean, MSIII; Ganesh Maniam, MSIII; Dr. Thien Vo, MD Vo, Thien MSIII; Dr. Dean, MSIII; Ganesh Maniam, Ryan Fatal Rectus Sheath Hematoma Secondary to Enoxaparin Administration Hematoma Secondary to Enoxaparin Fatal Rectus Sheath School: School of Medicine MS3-4 DEAN, RYAN MS3-4 DEAN, the development of the fatal RSH, but this is an area that requires future study tion of enoxaparin may have prevented This Conclusion: paper presented a case of an epigastric artery hematoma following enoxaparin administration, resulting in multi in outlined course clinical and factors risk the patient, the for fatal proved this While shock. hemorrhagic to secondary failure organ this case report may assist other physicians in preventing future cases of severe intra-abdominal hematomas following enoxaparin administration. School: School of Medicine Discussion: Radiation therapy is the treatment of choice as these tumors. Other treatment options include anti CD20 monoclonal an- monoclonal CD20 anti include options treatment Other tumors. these as choice of treatment the is therapy Radiation Discussion: common agent etiological for these patients is chlamydia psittacosis and a few patients may respond A tibodies and chemotherapy. case, this in orbits, the of involvement bilateral the of because However, relapse. for reserved often is Chemotherapy doxycycline. to regime. to the treatment to add chemotherapy it was decided - arrange beam laterals opposed an utilizing radiotherapy site involved definitive with treated were lesions conjunctival bilateral The ment technique. Three weeks after radiation the patient was started on 6 cycles of chemotherapy with Rituxamab, - Cyclophospha and prednisone. Vincristine mide,

ABSTRACTS 108 School: SchoolofMedicine that itwasnotpossibletoprecisely differentiatehemorrhagicversusischemicstrokesin theUNOSdatabase fact the by limited is study population. The post-transplant the in survival overall on period perioperative the in stroke a of impact negative the time first the for shows study This survival. in decrease early to due survival overall the and transplant post year first the in survival influence to appears also It discharge. to prior period post-transplant early the in mortality the increase to appears period perioperative in the event astroke of impact The Conclusion: (figure1). groups two the between different significantly not did not(p<0.001). a strokeeventperioperatively as comparedtothosewho transplantthesurvival ratewas yearpost After thefirst after discharge (p<0.001). This study also showed increased mortality in the first year after discharge in the group that experienced survival improved significantly had event stroke in-hospital any have not did who group Patients Ain (p<0.001). died % 4.2 only tients studied 513 had at least one stroke event prior to discharge (group B). Of these 26.7 % died prior to pa- 20915 discharge the Of Results: death. in to transplant of group date from B elapsed time the while as defined was survival Overall distributions. survival of comparisons make to used was test log-rank survival. The of estimates compute to used was method Kaplan-Meier period. The perioperative the in event stroke one least at experienced who patients 513 had B group while stroke no experienced who patients Group groups. two into divided was cohort patients. The 20,915 20402 had had cohort A study final request. The formal a through obtained was data transplantation. The cardiac underwent who 2015 and 2005 between age) of years 18 (≥ patients include to ried que- was database UNOS The Methods: population. this in survival overall on stroke of effect the addresses study This literature. Purpose: The impact of stroke in the immediate post-transplant period on overall long term survival has not been well defined in the Timothy Dixon,NandiniNair, MD,PhD Impact ofStroke inthePerioperativeperiodonOverallSurvivalofCardiac Transplant Patients MS3-4 DIXON, TIMOTHY School: SchoolofMedicine istering ShingrixasitisabletopreventmorbidityfromtheZosterrashandpost-herpeticneuralgia. caused arashinanimmunocompetentindividualisnotknown.However response. The componentsofthisrecombinantvaccinearenotknowntocauseareaction,andtherationaleonwhyShingrix system. GlycoproteinEelicitsanti-VZV immunitywhiletheadjuvantsystemstimulates VZV-specific antibodyandCD4 T-cell Shingrix isanadjuvantedsubunitvaccinemadeupofasinglerecombinant vaccine withnocomplications. she flewtothePhilippinesandreturned7dayslater. Shehadchickenpoxasachild,andpreviouslyreceivedtheZostavax her rightabdomenandthenprogressedtoback.Shedescribedthemas“tingly reported amildcaseofZosterrash3daysafterreceivingthefirstdoseShingrixvaccine.Itstartedwithvesicularlesionson A 73yearoldfemalewithpastmedicalhistory ofhypertension,hypothyroidism,andstageIIA infiltratingductalbreastcancer the Shingrixrecombinantvaccine. Here wereportauniquecaseof73yearoldimmunocompetentpatientwiththeZosterrashpost-vaccineadministrationdueto individuals over50yearsofage. cephalitis. Duetothecomorbidityassociatedwiththisdisease,herpeszostervaccinehasbecomeawidely-soughtfor lesions withunilateraldermatomaldistribution.Itcanbefurthercomplicatedbypost-herpeticneuralgiaorherpeszosteren is immunocompromisedfromstressorincreasedage.Shinglespresentsasamaculopapularrashthatcanevolveintovesicular presenting aschickenpox,andremainsdormantinthedorsalrootganglia.Itisoftenreactivatedlaterlifewhenindividual Herpes Zosterisadermatomalrashthatcausedbyreactivationofthe Nikita Dhir, Texas Tech HealthSciencesCenterLubbock;Dr. NehaMittal, Texas Tech HealthSciencesCenterLubbock Case ofHerpesZosterReportedafterShingrixVaccination MS3-4 DHIR,NIKITA Varicella Zoster Virus (VZV). VZV occursinchildhood, , thiscasereportshouldnotdeterphysiciansfromadmin VZV antigen, glycoproteinE,andthe AS01B adjuvant , itchy, andtender”. The dayaftertherashonset, - - 109

ABSTRACTS - School: School of Medicine Discussion: Our results indicate that an effective wellness programhad lasting impact on the in the initiative skills students developed by participating The stress-management the home institution. can be accomplished with minimal financial support from approach to further students’ stress. With development, this model could be sustainably reproduced by other schools to promote a medical education community that supports the wellness of students. Results: 135 out of 183 second year medical students participated in the initiative and completed a total of 10 1,023 weeks for an average of 7.5 activities activities per participating student. One student over participated in 66 activities. Exercise was the most 52 common students activity. of the class of 2021 completed an anonymous survey after the project. Of the initiative participants, 94% Initiative agreed incentivized that their the Wellness participation in wellness activities and 66% said that the initiative had a long term effect on their approach to stress. Methods: Participation in workouts, parties, the watch Anatomy project was Grey’s days, encouraged donut included: Examples via activity. email of types and and dates, a names, tracking Form social Google media campaign. Students submitted entries via a and therapy dogs. Prizes were awarded at the end of the initiative. age camaraderie and collaboration to help medical students develop healthy coping strategies. age camaraderie and collaboration to help medical students develop healthy coping Background: USMLE Step 1 is a major source of stress for second year medical students at TTUHSC School of Medicine. As the re- the As Medicine. of School TTUHSC at students medical year second for stress of source major a is 1 Step USMLE Background: Many 1. Step for preparing time of amount significant a spend students placement, residency impact increasingly exam this of sults a as isolated become students Some anxiety. and stress heightened of period this during habits healthy maintain to struggle students result of poor stress management leading to negative outcomes like remediation or delayed advancement. Our goal was to encour Alec Egan, Megan Gates, Allison Perrin PhD, Dan Webster PhD Webster Allison Perrin PhD, Dan Alec Egan, Megan Gates, Student-Led Second Year Medical Student Wellness Project Medical Student Wellness Student-Led Second Year MS3-4 EGAN, ALEC MS3-4 EGAN, School: School of Medicine Atypical Desmoplastic Cellular Neurothekeoma is a rare benign lesion that has a high propensity for the face and upper extremities extremities upper and face the for propensity high a has that lesion benign rare a is Neurothekeoma Cellular Desmoplastic Atypical present the case of of a female We 42 patients. year old woman, Fitzpatrick type I, with a several month history of a growing well demarcated pearly pink 8mm nodule with arborizing and linear irregular vessels on her mid forehead. The differential diagnosis included basal cell carcinoma, squamous cell carcinoma, amelanotic melanoma, sebaceous carcinoma, follicular neoplasm, adnexal Histology tumor. revealed a and mildly atrophic epidermis overlying a proliferation of epitheliod cells with abundant ampho- philic cytoplasm and moderately pleomorphic nuclei arranged in vague fascicles embedded within a fibrous capsule.The lesion displayed an infiltrative growth pattern toward the base. Melanocytic stains Mart 1, S100, and Sox-10 appropriately highlighted a normal periodicity of melanocytes at the dermal epidermal junction. Pancytokeratin stained the overlying epidermis appropriately highlighted faintly CD68 index. proliferative increased moderately a demonstrated Ki-67 cells. neoplastic the highlight not did and the cells epithelioid of interest. CD10 and NKI-C3 strongly and diffusely stain the epithelioid cell of interest. P16 staining exhibits a biphasic staining pattern within the lesion, with strong mosaic staining in the superficial aggregates of epithelioid cells and loss diagnosis the Thus, lesion. the of base the toward pattern growth infiltrative an with cells, atypical more the in p16 of expression of regarding limited is literature The planned. is excision complete and declared was neurothekeoma cellular desmoplastic atypical of clinicians distinguish this neoplasm in the future. this diagnosis, and this report aims to help E.L. Domingo-Johnson MSIII, Brett Austin M.D., Ashley Sturgeon M.D., Michelle Tarbox M.D Tarbox M.D., Michelle Ashley Sturgeon M.D., Austin Brett MSIII, E.L. Domingo-Johnson MS3-4 DOMINGO-JOHNSON, E.L. DOMINGO-JOHNSON, MS3-4 Neurothekeoma Desmoplastic Cellular Atypical Case report:

ABSTRACTS 110 tion injuryascompared tothosewithoutapositive bronchoscopyscore. Patients with a positive bronchoscopy score were 9 times more likely (OR=9.91, 95% CI = 2.8-35.01) to be diagnosed with inhala significant a (p<0.001; injury no and inhalationinjury conditionof our for positive those between positivebronchoscopy difference in was 1). Table There injury. injury/burn inhalation smoke of diagnosis and 5/31/18, and 1/1/2004 from admission 18-89, age red oropharynx on physical exam. If the patient met one of these conditions, we considered this a positive result. Inclusion criteria: a or wheezing, hoarseness, with along patient the on present sputum carbon or soot of consisted findings exam Physical 1-4. score Results: A positive bronchoscopy score was defined on the condition of having positive physical exam finding and/or bronchoscopy outcome variablesweredeterminedusing Wilcoxon ranksumtestforcontinuousvariablesandChi-squaredcategorical. predictor/ between Differences inhalation. smoke for positive considered was this predicted, than fluid more received patient the kg* in (2cc*weight formula Brooke modified the by predicted that to compared treatment of hours Surface24 Burn Total If Area). first the in required fluid (1-4). resuscitation score was numerical outcome and primary carina, The at particles carbon mucosa, red included: findings Bronchoscopy inhalation. smoke with associated outcomes and course, hospital comorbidities, bronchoscopy, arrival, on intubation level, carboxyhemoglobin presentation, clinical demographics, evaluated study retrospective This Methods: scoring systeminordertodevelopanobjectivemethodthat considerstheseverityofinhalationinjury injury inhalation smoke accurate an create to used be could that variables examine to was goal primary The outcomes. to findings these comparing by inhalation smoke of suspected patients on performed characteristically studies adjunct and location, history, exam, physical of significance diagnostic assess to sought study This subjective. is interpretation its injury,but inhalation smoke Introduction: Smoke inhalation injury is strongly associated with increased morbidity/mortality. Bronchoscopy is used to diagnosis PhD, RohaliKeesariMPHPharmD,JenniferKeseyMSNRNRNP-BCCWS,JohnGriswoldMDF Nicole Van Spronsen BS, Grant Sorensen PhD, Joshua Frost BA, Jordan Howell MBS, Donna Ayala BS, Hasan Almekdash MA MS Retrospective PilotStudytoExaminePotentialPredictors ofaStandardized ScoringSystemforSmokeInhalationInjury MS3-4 FROST, JOSHUA School: SchoolofMedicine ing tooptimizetheSA diagnosticalgorithm. The results of our study add to the growing body of literature surrounding PCT in SA and provide valuable data for physicians aim specificity =81.2%). TheidealcutoffpointforESRwas84.5mm/hr(sensitivity=50.0%,specificity78.1%). was 0.275ng/mL at (sensitivity = 84.6% , specificity = 59.4%). The ideal cutoff point for CRP was 21.1mg/dL (sensitivity = 69.2%, PCT for point cutoff respectively. ideal 56.2%, The and 84.6% were sensitivity and specificity 0.25ng/mL, of cutoff PCT a Using = 0.002). curve (AUC) for PCT was 0.74 (p = 0.002), compared to 0.74 for CRP (p = 0.002), 0.65 for ESR (p = 0.002), and 0.55 for the WBC (p under area The sepsis. of presence/absence with association significant showed levels 0.002) = TKA(p and 0.002) = (p CRP SA. detecting CRPin PCT,and of ESR, accuracy WBC, the assess to analysis curve (ROC) characteristic operating receiver and tests U Whitney Mann using aseptic), 34 and septic (26 arthritis knee acute with patients consecutive 60 reviewed Weretrospectively sensitivity andspecificityfordiagnosingSA. ng/mL greater 0.25 provides of a threshold that suggests cutoffs lower regarding data published limited. The is points cutoff lower consideration as a diagnostic biomarker under SA. PCTcome has has shown some (PCT) utility at Recently,procalcitonin a cutoffinfections. levelknown of 0.5ng/mL,monitor however,to literature assessing used typically are and value diagnostic low have to shown been have markers these fluid, synovial in sepsis of predictors as used often are (CRP) protein C-reactive and (ESR), rate sedimentation erythrocyte (WBC), cells blood white While SA. diagnose reliably to available marker laboratory single no is there Early diagnosis of septic arthritis (SA) can help avoid serious complications that arise from prolonged infection of a joint, however, Kevin West, MD,JohnFisher, MBA,CameronCox Procalcitonin asanEarlyMarkerofSeptic Arthritis MS3-4 FISHER,JOHN ACS . - - 111 ABSTRACTS - - Background: Acute Background: colonic pseudo-obstruction (ACPO), formerly known as syndrome, Ogilvie’s is a functional obstruction char Megan Gates, Elmira Ahnood, John Griswold M.D. FACS Ahnood, Megan Gates, Elmira Unique Aspects of Acute Colonic Pseudo-Obstruction in Morbidly Obese Burn Patients Acute Colonic Aspects of Unique MS3-4 GATES, MEGAN MS3-4 GATES, School: School of Medicine Conclusion: Because burn patients require extensive healing time, they are more prone to Therefore, ACPO. recurrent episodes of preventing in beneficial be may cecostomy and colonoscopy with decompression colonic active as such treatments aggressive more complications such as colonic perforation. Results: Patient A is a 55 year old male with 37% TBSA who suffered serosal tears at his distal cecum which were repaired and re- and repaired were which cecum distal his at tears serosal suffered who TBSA 37% with male old year 55 a is A Patient Results: cecal pinpoint a had who TBSA 21.5% with male old year 54 a is B Patient bowel. the of decompression for drain Malecot a ceived perforation and underwent a right hemicolectomy with eventual anastomosis. Methods: Both patients presented after suffering partial and full thickness burns with a history of morbid obesity. Throughout their Throughout obesity. of morbid a history burns with thickness full and suffering partial after presented patients Both Methods: After ACPO. for concerns with distension and pain abdominal of episodes waning and waxing experienced each they stay, hospital worsen- acutely Overnight, flatus. with movements bowel have to continued and improved both management, medical conservative ing distension developed in each patient. Objective: Here, we will describe two cases of ACPO with unusual presentations in morbidly obese burn patients. ACPO with unusual presentations Objective: Here, we will describe two cases of acterized by massive colonic ACPO distention. is typically seen in patients who experience an inciting event causing hospitaliza abdominal includes ACPO of presentation usual The issues. health chronic existing to addition in pneumonia or UTI a as such tion ACPO with patients of 40% to up However, rectum. empty an and flatus, or stool pass to failure vomiting, nausea, pain, distention, may still pass flatus or stool. Gastrointestinal dysfunction is common in burncomplication. patients with ACPO being a rare life-threatening School: School of Medicine School: School Applicability Applicability of Research to Practice: Due to the 9-fold benefit of it performing should bronchoscopy, be the primary tool used to in nature. may be secondary injury; other tests smoke inhalation assess potential Conclusions: These results display the importance of bronchoscopy in suspected smoke inhalation injury and reinforce the need for need the reinforce and injury inhalation smoke suspected in bronchoscopy of importance the display results These Conclusions: guide to system scoring objective an creating by results upon these build can studies Future assessment. bronchoscopy objective an performing bronchoscopy. providers

ABSTRACTS 112 School: SchoolofMedicine on theleft.Furtherstenosis-limiting treatmentwasrequiredafterresectiontopreventthe returnofherhearingloss. of the EAC meningioma was performed. On the third post-op visit the patient again complained of headaches and decreased hearing sualization of the tympanic membrane. CT scan showed a soft tissue density within the left temporal bone. A left bony canaloplasty decreased and headaches hearing on with the left for clinic 9 years. Clinical the exam revealed a to large bulging presented mass within the meningiomas left external intracranial auditory canal (EAC) multiple without vi- of history a with female 49-year-old A Brianna Hope,MS3;Rahul Varman, MD;JoehassinCordero,MD Recurrent External Auditory CanalMeningioma:CaseReport MS3-4 HOPE,BRIANNA School: SchoolofMedicine enhancing communication. and education personalizing towards future the focus to us allowing needs; diagnostic on based visits Ophthalmologist patient’s specialties. time todeterminewhatinterventionsarenecessaryimproveoutcomesacross to triage us This systemlendsitselffor for R2R, and likely R2C skyrocketed. Now,more instead of individual encounters we group patient 100% information and follow their condition in real- over now is It care. in consistency allowing information, to access streamlined CB-EMR to Transitioning munication. com- in records.Delays previous Unconsolidated responsibilities. management of Distribution R2C. and contact for triage of Lack Conclusion: CB-EMRaddressedthepitfallsofouroldsystem: Likelihood of R2R comparing 1st encounter patients: 44% vs 92% OR 0.0647, 95% CI (0.0193 to 0.2167) z stat 4.441, P<0.0001 R2C to5and6Encountersoccurredwith31patientsonlyafterCB-EMR.(↑100%,↑100%) R2C to4encounterswentfrom43%100%(↑57%) R2C to3encounterswentfrom28%100%(↑72%) R2C to2encounterswentfrom7%93%(↑86%) R2R after1stencounterwentfrom44%to92%(↑48%) Results: 530encountersafterCB-EMR: of recordswiththe TTUHSC LIFCDatabase,aCB-EMRwascreated. medical prognosis and triaged by plan of care (POC) into prognosis specific categories for return to care (R2C). Upon consolidation Methods: We analyzed data before/after CB-EMR implementation (N=530). Patients were contacted to reestablish, briefed on their we analyzedpredictorsofretentioninoursystemtocreateaCloud-BasedElectronicMedicalRecord(CB-EMR) uncommon. Therefore, was (R2R) resolution to retention encounters, for clinics. Withsystem free decentralized in a problem tous a ubiqui- follow-up; to loss meant custody. lapses of Communication chain and communication in issues with inefficient, but safe was This students-physicians. between USB via done originally was screenings retinal LIFC TTUHSC of Analysis Introduction: bock ImpactFreeClinic(LIFC),Lubbock, Texas Lub- 2TTUHSC States Texas,United Lubbock, (TTUHSC), Medicine of School Center Sciences 1TexasHealth TechUniversity Andrés E.Guerrero-Criado1,2,GnanashreeDharmarpandi1,2,KellyMitchellMD1,2 Sciences CenterFree Clinic Cloud-Based Improvement of Patient and Provider Communications Regarding Retinal Screening at Texas Tech University Health MS3-4 GUERRERO CRIADO, ANDRES 113

ABSTRACTS - - s sarcoma. ences were found between English and Spanish speakers in the number of women breastfeeding, father involvement in care and plan and care in involvement father breastfeeding, women of number the in speakers Spanish and English between found were ences to have family or friends care; involved Spanish in speaking the women newborn’s are more likely to involve the extended family barrier for prenatal care for Spanish speakers. care. Distance was the largest in the newborn’s Results:Respondents were Spanish speakers (80 responses)and English speakers (175 responses). Statistically significant differ Methods:Data was collected via surveys distributed among mothers of newborns in the postpartum unit of Northwest Texas Hospital Texas Northwest of unit postpartum the in newborns of mothers among distributed surveys via collected was Methods:Data Bilingual volunteers and certified online translation sites translated surveys from English to Spanish, Burmese, Texas. Amarillo, in Zumi, Chin, Karen, and Somali. Questions regarded demographic information and cultural traditions surrounding newborn care practiced by parents, such as prenatal care, breastfeeding, circumcision, umbilical newborn cord safety, care, family involvement, and bonding. Introduction:Healthcare providers’ cultural competencies are challenged daily through the lack of cultural awareness of the diverse the of awareness cultural of lack the through daily challenged are competencies cultural providers’ Introduction:Healthcare increase help to refugees, including community, local the within traditions care newborn assesses study This serve. they populations awareness among healthcare providers and strengthen their ability to provide exceptional health care tailored to the unique needs and customs of this population. Bella Kalayilparampil, Stacy Philip, Alan Gonzalez, Sumesh Parat Bella Kalayilparampil, Stacy Philip, MS3-4 KALAYILPARAMPIL, BELLA MS3-4 KALAYILPARAMPIL, Texas West in on Newborn Care Influence of Cultural Background We report a case of a 33-year-old male with medical history of dyslipidemia who presented with progressively worsening shortness worsening progressively with presented who dyslipidemia of history medical with male 33-year-old a of case a report We patchy revealed X-ray Chest cough. productive and weather, cold in especially activities daily with difficulty weeks, 3 for breath of syndrome coronary acute and embolism, pulmonary pneumonia, included diagnosis Differential lungs. bilateral in opacities airspace echocardiography showed an ejection fraction of <20% and dilated cardiomyopa Transthoracic due to elevated troponin levels. Chia Hsu, E.L. Domingo-Johnson, Siroj Dejhansathit, MD, Marcella Rivas, MD. Chia Hsu, E.L. Domingo-Johnson, Siroj Severe Heart Failure Secondary to Dilated Cardiomyopathy in a 33-year-old Man in a 33-year-old Cardiomyopathy Secondary to Dilated Heart Failure Severe MS3-4 HSU, CHIA MS3-4 HSU, School: School of Medicine School: School of Medicine School: School of Medicine steroids anabolic-androgenic using been had patient the that found was it etiology, failure heart the of investigation further Upon thy. and herbal supplements to boost his performance in weightlifting. His testosterone level was found to elevated. In the absence of severe and cardiomyopathy dilated patient’s the attribute we etiologies, other for findings laboratory negative and factors risk other heart failure to the anabolic-androgenic steroid abuse. Our case highlights the importance of considering anabolic-androgenic ste- young patients who present with acute heart failure. roid use in the differential diagnosis of We describe We a 79-year-old female with non-HIV associated Kaposi’s sarcoma who for the last 10 years develops approximately 10-15 cutaneous neoplasms every 2 to smaller 4 lesions months. were Initially, successfully removed using punch methods, while larger lesions would require surgical excision. However, the patient developed “surgical fatigue” with this process. For over two years she has now been successfully managed with intralesional vinblastine. This treatment has been much more tolerable for her the Kaposi’ effects nor systemic progression of without systemic side Landon Hope, MS3, Andres Garcia, MD, Michelle Tarbox, MD, Richard Hope, MD MD, Tarbox, Michelle Andres Garcia, MD, MS3, Landon Hope, MS3-4 HOPE, LANDON HOPE, MS3-4 Vinblastine with Intralesional Managed Sarcoma Kaposi’s Non-HIV

ABSTRACTS 114 School: SchoolofMedicine as used platform fornutritional interventioninpregnancy. be might and trimester first for intake food accurate gave MyFitnessPal pitfalls, revealed Despite approach. team-based multidisciplinary and adjustments additional require apps phone-based smart of applications population, pregnant In Conclusion. novel computerizedpatient-investigator interfaceforpersonalizedappapplication. creating are Investigators (2). population Mexican from different was it but population, European for reported to similar was data population, rural Despite study,trimester,50. Ongoing second is Discussion the patients in targetof continues number intake food g/day RDA and12.5%< 135 gEARrespectively. kg/m2. F, COH and P intakes were similar published study (n=30) (1). TE, P and COH were 87.5% < 9946 kJ REE, 75% < 71 32.1±7.2 BMI and 177.8lbs±41.3lbs weight years, 24.4±2.9 entries. was food patients trimester of first Age completed seven data; record incomplete/absent had or yet entries food shared study,not discontinued had three nine patients, enrolled 19 From Results. R statisticalsoftware(version3.5.2)and(SPSS). lated and compared to EAR. Outcomes compared with publishedreference values [REF] (1,2)in Wilcoxon signed rank tests using Medians (25th; 75th percentile) of main nutrient groups (Protein [P], Carbohydrates [COH], Fats [F]) and total energy (TE)) calcu app. mobile in incorporated and ID pregnancy. specific of using trimester shared first was in intake weeks Food two MyFitnessPal using intake food log to asked and L20-032) # protocol (IRB pregnancy of trimester first in Womenenrolled Design. were Study documenting foodintakeinruralpopulationofpregnantwomenasaplatformfornutritionalinterventions. (MyFitnessPal) app Mobile of application evaluate to was study this of Goal management. diseases in tools powerful been have technologies phone-based smart Innovative problem. health public pressing a is US in mortality maternal Increasing Introduction: Department ofNutritionalSciences, TTU, Lubbock, TX Professions, Health of School Care, Primary and Sciences Laboratory of partment Midland, Basin, Permian the at TTUHSC 3 TX; 1 Department of Obstetrics and Gynecology, Texas Tech University Health Sciences Center at the Permian Basin, Odessa, TX; 2De- Wilna Oldewage3,Ph.D,ChristopherEnakpene1,MD,andN. Schlabritz-Lutsevich1,MDPhD. MS, Lee3, Hyunjung Ph.D, Kahathuduwa2, Chanaka MS3, Khandewal1, Jaanki MD, Mannem1, Maneesh MS3, RyanArispe1, WOMEN AT THEPERMIANBASIN:PRELIMINARY REPORT POTENTIAL PITTFALS OF SMART-PHONE APP BASED EVALUATION OF FOOD INTAKE IN POPULATION OF PREGNANT MS3-4 KHANDELWAL, JAANKI School: SchoolofMedicine adress themclinicallyinthisposter. to how and sequlae potential its and injury lung induced vaping developed approach subsequently WeARDS. to how review will then pneumonia induced vaping developed who history medical past significant no with patient female 35-year-old a Wepresent John KelleyMS4,Dr.Shane Metzler Vaping inducedLungInjuryandDVT MS3-4 KELLEY, JOHN School: SchoolofMedicine populations foroptimalhealthcareprovisions. these in address to disparities additional exploring and participation refugee recruiting care entails research Further up doctors. their from follow seeking women for barrier important most the is Distance speakers. Spanish among care newborn in importance more has family extended the of role breastfeeding. The of benefits the on education further for need the highlight preferences ing Conclusion:This study enlightens healthcare providers on the importance of cultural competency when caring for newborns. Feed- - 115

ABSTRACTS School: School of Medicine CONCLUSION: Therapeutic prognosis for LA has thus far been demonstrated to be and surgery, systemic therapies poor have shown as minimal or no topical improvement in reported and cases. However, PRP acts intralesional on growth steroids, factors required for the survival of hair follicle-keratinocytes and has been successful in the treatment of conditions such as of LA. is a modality that warrants consideration in the treatment alopecia, alopecia areata, and cicatricial alopecia. PRP androgenic CASE: A 44-year-old Hispanic female A presented CASE: with a thickened, boggy frontal and vertex scalp for many years. The patient en- LA. with consistent findings showed biopsy a and imaging Ultrasound pressure. with tenderness and burning, pruritus, scalp dorsed clobetasol triamcinolone, intralesional of injections several antibiotics, several to recalcitrant was she years, 6 next the Throughout injections 6 undergone has She PRP. of trial a undertake to opted subsequently patient The finasteride. and gel, tazarotene solution, to date with significant improvement clinically and on post-procedural ultrasound and biopsy. of PRP BACKGROUND: Lipedematous alopecia (LA) is a rare, nonscarring alopecia that manifests with increased thickness of the subcu- the of thickness increased with manifests that alopecia nonscarring rare, a is (LA) alopecia Lipedematous BACKGROUND: pres- be may and color of women in described predominantly been has but unknown is LA of Etiology scalp. the in layer fat taneous ent simultaneously with an inflammatory alopecia. Exam reveals a thickened, boggy scalp, usually favoring the vertex or occipital there are no guidelines that exist scalp. for Currently, the treatment of LA. In general, the literature has shown platelet rich plasma (PRP) to be a valuable therapeutic option for other types of Thus, alopecias. we decided to undertake a trial as of a PRP treatment with good therapeutic response to PRP. our knowledge, we report the first known case of LA To option for our patient with LA. Christine P. Lin, BA, Jeannie Nguyen, MD, Michelle Tarbox, MD Tarbox, Lin, BA, Jeannie Nguyen, MD, Michelle Christine P. MS3-4 LIN, CHRISTINE MS3-4 LIN, Female Alopecia in a Hispanic as a Novel Therapy for Lipedematous Plasma Rich Protein School: School of Medicine Conclusion: Histopathologically, it is impossible to tell if the paraganglioma is benign or malignant; metastasis is the only definitive only the is metastasis malignant; or benign is paraganglioma the if tell to impossible is it Histopathologically, Conclusion: Thus adequate completion of therapy and close sign follow-up of afterward malignancy. are vital in monitoring for recurrence and metastasis. Four months later, he presented with left arm numbness and tingling, left facial and pulmonary and neck osseous metastasis with pathologic compression fracture deformity paresthesia. T10-T12. from abdomen, CT pelvis, head, and CT chest showed diffuse spine showed extensive metastasis involving the liver and lung; C6, C7; L3, L4, L5 with mass effect on cauda equina; S1, S2, bi- lateral ilium, paraspinal muscles extending into the lumbar spine and epidural space. Three weeks later he developed tachycardia, bilateral lower leg pain with decreased strength and limited range of motion on the right. He started palliative chemotherapy with unfeasible. as the extent of metastasis made surgery and Capecitabine Temodar Case: A 31 A Case: year old male presented with right-sided abdominal pain, 20lb weight loss in two months, bilateral leg weakness, and bowel retention. Pelvic CT and lumbar spine MRI showed a kidney mass on the psoas muscle and a paraspinal mass at T10 with vertebral invasion, cord impingement, and compression fracture. Neurosurgery and thoracic the of xray Last performed a Temodar. with therapy radiation completed He paraganglioma. as back came pathology laminectomy T9-T11; from with tumor resection follow-up. no acute findings and he was lost to lumbar spine showed Introduction: Paraganglioma is a rare neuroendocrine tumor found in 2 out of a million people annually. It is a benign, slow growing slow benign, a is It annually. people million a of out 2 in found tumor neuroendocrine rare a is Paraganglioma Introduction: with cancer, 25% of cases associated with hereditary syndromes. It is extra-adrenal tumor arising from sympathetic and parasym- high causing bursts, uncontrolled in catecholamines release can it bomb,” time “pharmacologic the as Known paraganglia. pathetic heart attacks, death. blood pressure, stroke, Shanshan Lee; Lukman Tijani, MD Tijani, Lee; Lukman Shanshan MS3-4 LEE, SHANSHAN MS3-4 paraganglioma metastatic case of rapidly progressive rare A

ABSTRACTS 116 School: School ofMedicine by a trained dermatologist is typically warranted – biopsy of the lesion is the gold standard diagnostic method for such presentations. loma annulare is one such disease that is often misdiagnosed due to its relative rarity. In the case of granuloma annulare, evaluation Conclusion: Successful treatment of rare dermatopathology requires exclusion of common mimics and the correct diagnosis. Granu- of triamcinolone,whileother optionsincludephototherapy, cryotherapy, andsaline injections. The damage. disease is often macrophage self-limiting, but patients and may desire treatment when chemotaxis, it persists. First-line treatment neutrophil includes intralesional injections defective reactions, hypersensitivity including literature the by been suggested have mechanisms proposed Several bites. animal and tattoos, trauma, local include exposures environmental HIV, and tuberculosis; disease, thyroid mellitus, diabetes age, young sex, female history, family been have include factors factors risk predisposing the well-identified: though unknown, yet is disease the of etiology The extremities. lower & upper the typically borders, Discussion: Granuloma annulare is an idiopathic skin lesion disorder that most commonly presents as a localized plaque with raised tology forremoval. examination and biopsy, the lesion was instead determined to be granuloma annulare. The patient was referred to outpatient derma gross Upon cream. triamcinolone with treated and eczema nummular as misdiagnosed been had rash the and symptoms, other no had She arm. her on rash new a about concerned mildly was but visit routine a for presented female Report: A65-year-old Case esis hypothesis,aswellthelesionsforphysicians. tis. This case presents an uncommon case of granuloma annulare with a discussion of differential diagnosis, risk factors, pathogen pruri- mild from aside asymptomatic generally and idiopathic is that dermatopathology rare a is annulare Granuloma Introduction: Ganesh Maniam,MSIII;Dr. Jack Waller, MD Current HypothesesofGranuloma Annulare Pathogenesis: A CaseReport MS3-4 MANIAM,GANESH School: SchoolofMedicine hearing lossispresumedtobethepatient’s TBI. sensorineural the of cause The canal. auditory external the of portion bony atretic congenitally undiagnosed previously the likely Synthesizing the findings of the patient’s history, EOA, and CT, it was determined that the cause of the conductive hearing loss was as wellsofttissuedensityinthehypotympanumandmastoidaircells. temporal bone. Computed tomography (CT) demonstrated stenosis and deformity of the bony portion of the external auditory canal the image to elected we patient, this congenital. in Towas deformity atresia of the degree that the suggests characterize scar better acquired of lack scar.The acquired an without canal atretic an have to found was patient the (EOA), anesthesia under Exam On etry demonstratedreduced TM compliancewithpossibleeffusion. of the left tympanic membrane (TM) was difficult. Pure tone audiometry demonstrated profound mixed hearing loss and tympanom One month later, the patient presented with persistent hearing loss, tinnitus, ear pain and ear discharge in the left ear. In-office exam mal hemorrhage. Active bleedingfromtheleftearwasappreciatedoninitialphysicalexam. parenchy- transverse left and displacement canal auditory external with fracture bone temporal left a edema, cerebral hemorrhage, aging in the emergency department revealed an acute subdural hematoma in the left posterior fossa with left cerebellar hemispheric A 10-year-old patient was referred to our service for evaluation of hearing loss following a traumatic brain injury (TBI). Initial im- are affectedsimultaneously. the and/or cochlea the affects hearing sensorineural and conductive both when occurs loss hearing Mixed nerve. Vestibulocochlear middle ear prevents vibrations from reaching the round window. Sensorineural hearing loss occurs when damage or disease directly Hearing loss can be classified as conductive, sensorineural or mixed. Conductive hearing loss occurs when pathology of the outer or Nathan Lloyd,JoshuaDemkeMD An Anomalous CaseofProfound MixedHearingLossinanOlderChild MS3-4 LLOYD, NATHAN - - - 117

ABSTRACTS - - - , it is found in a young adult , it is found in a young , WBC count, bilateral lung , , and a history of extensive use , and a history of extensive , and a 15 lb weight loss over a two-week pe , and a 15 lb weight Ceftriazone/Azithromycin. Despite antibiotics, Ceftriazone/Azithromycin. riod. She was afebrile during admission though her respiratory status significantly fluctuated. She gave a 3-year history of heavy status significantly fluctuated. She during admission though her respiratory riod. She was afebrile WBC count on interstitial, alveolar infiltrates and normal showed bilateral of smoking nicotine. CT year history vaping and 11 pneumonia with IV initially treated for community acquired admission. She was with the initial 2 days with significant neutrophil leukocytosis and worsening hypoxemia her clinical condition worsened during conserva In view of the possibility of vaping induced pneumonitis, she was managed increasing need of supplemental oxygen. School: School of Medicine tively with bronchodilators and respiratory toilet. She showed clinical improvement on the 5th day with improving oxygenation toilet. She showed clinical improvement on the 5th day with improving oxygenation tively with bronchodilators and respiratory patient with pneumonia case highlights the severity of the decline in lung function of a young WBC count.This and decreasing after the recent heavy use of e-cigarettes. School: School of Medicine Discussion: This case highlights a delay in the treatment of delirium in a patient with a significant psychiatric history. The patient’s patient’s The history. psychiatric significant a with patient a in delirium of treatment the in delay a highlights case This Discussion: criteria delirium all if only diagnosed be can mania Bipolar polypharmacy. with toxicity anticholinergic to due likely was delirium hypertensive and anticholinergic of management better with balance electrolyte and status mental good maintained She met. not are medications. Case Presentation: A Case 57-year-old A Presentation: female nursing home resident with a past medical history of bipolar 1 disorder presented to the 20s her in attempt suicide a for notable was History stimuli. internal to response and delusions paranoid with psychosis acute in ED and a benzodiazepine overdose 6 days prior to this showed: admission. studies laboratory Her psychosis, current her medication for list admission indicated Upon polypharmacy pain. to chronic control and her hypertension, seizures, insomnia, disorder, I bipolar normal TSH, low free T4, hyponatremia (96mEql/L), hypochloremia (133 mEq/L), and elevated BUN (21 urine A mg/dL). drug prior weeks 4 initiation amitriptyline include factors precipitating formulation, biopsychosocial Per opiates. for positive was screen to admission and insomnia due to the recent loss of family members. Perpetuating while factors protective include polypharmacy, factors include no suicide attempts in over 30 All years. psychotropics were held. On day 2, the patient had no pressured speech and a normal mental status exam. On day 3, she deteriorated with complete metabolic panel indicating marked hyponatremia (125 remained negative. mEq/L) and hypochloremia (93 mEq/L), though her blood and urine cultures Introduction: Delirium presents history, with psychiatric significant disturbances a with in patient a attention in and present When awareness, out. ruled can been develop have causes acutely medical other and all after fluctuatediagnosed be inmust severity, and diagnosis and treatment may be delayed or missed. Trisha Modi, Simon Choi Trisha MS3-4 MODI, TRISHA Patient Delirium Due to Polypharmacy in a Psychiatric Case: A 31-year-old female, with a significant 3-year history of e-cigarette use, presented to the ER with symptoms of worsening to the ER with symptoms of worsening 3-year history of e-cigarette use, presented female, with a significant 31-year-old A Case: subjective fever pain, non-productive dry cough, vomiting, dyspnea, pleuritic chest cal status with acute lung injury presenting as hypoxemia with pulse oximetry <90% on room air pulse oximetry <90% on room lung injury presenting as hypoxemia with cal status with acute macrophages. Epidemiologically with bronchoalveolar lavage showing lipid-laden infiltrates on CXR of breathing, nausea, vomiting, fever experiencing tachypnea, increased work aged 18-35 clinically progression of lung damage can possibly lead to an even more rapid concentrates found in e-cigarettes, which of marijuana oils or toxins like cigarettes. when compared to other Background: The use of electronic-cigarettes (e-cigarettes) has resulted in increased vulnerability to pneumonia in the young to pneumonia in increased vulnerability has resulted (e-cigarettes) The use of electronic-cigarettes Background: clini a decline in lipoid pneumonia involves associated life-threatening e-cigarette presentation of The most dreaded population. Ashley Maveddat, Trisha Modi, Santhosh Koshy, MD, Swagat Parajulee, MD MD, Swagat Modi, Santhosh Koshy, Trisha Ashley Maveddat, MS3-4 MAVEDDAT, ASHLEY MAVEDDAT, MS3-4 Compounds to Inhalation of Toxic Injury Secondary Acute Lung

ABSTRACTS 118 School: SchoolofMedicine Graves’ disease. the relationship between hyperthyroidism and thymic hyperplasia is critical to preventing unnecessary proceduresinpatients with mone (TSH) was 0.01 µUnit/mL and his Thyroxine (T4) was 2.08 ng/dL. The patient was treated with methimazole. Understanding roidism and positive thyroid stimulating immunoglobulin. The patient’s thyroid function tests reviled his Thyroid Stimulating Hor masses often resolve upon treatment of the underlying hyperthyroidism. Here we report a 64 year old man with untreated hyperthy- benign These hyperplasia. thymic the of etiology the establish to workup endocrine proper a without thymectomies have patients Thymic hyperplasia is commonly associated with Graves’ disease. Because of the potential concern for malignancy, many of these Karl Mueller, Ana Rivas-Mejia A Caseof aPatientwithMediastinalMass,anImportant Association withHyperthyroidism MS3-4 MUELLER,KARL School: SchoolofMedicine tions. Findingssuggestthatintraoperativebloodlossisonlyasmallcontributiontooverallloss. Conclusions: Reporting of intraoperative blood loss correlates poorly with total perioperative blood loss estimations using calcula 0.089] andwasnotsignificantlydifferentfromzero.Hence,thereispooragreementbetweenthetwomethods. Bland- The 0.001). < Altman plot showed a consistent under-reporting in RBL = with regard to EBL. The CCC between RBL p and EBL 2277, was 0.035 [-0.016, = W ml, -1691.981 = (Δ EBL to compared as under-reported significantly was RBL Results: the agRee andblandrpackagesinRstatisticalsoftware. using plots Bland-Altman and iterations 50 employing approach a bootstrap via (CCC) coefficients correlation concordance medians, group the compare to performed considering-values less than was 0.05 as significant. The agreement and reproducibility oftest RBL and EBLrank were examined by calculating signed Wilcoxon two-sample a and variables summarize to used were ranges inter-quartile and Medians software. statistical R using conducted were analyses statistical All values. hematocrit erative postop- days 2-3 and preoperative the using Method Gross the using calculated EBLwas case. each in reports anesthesiology the RBL2/28/2019. from to taken 3/1/2017 was from old years 89 to 18 ages between fracture pelvic of repair open and/or repair ture Methods: A cohort study was conducted at a Level 1 trauma center. The population studied were patients requiring acetabular frac- Method ofestimatedbloodloss(EBL). Gross the using loss blood perioperative calculated total the to compared as (RBL) loss blood intraoperative reported the evaluate mately 6%. In addition, surgeries to repair pelvic and acetabular fractures often results in high blood loss. The aim of this study is to approxi- is fractures ring pelvic with patients of rate mortality the and trauma, blunt after frequent are injuries Pelvic Background: mond, MD; Ariel Santos,MD Tanir Moreno, BS; Samudani Dhanasekara PhD; Nicole Van Spronsen, BS; Caroline Chung, BS; Cyrus Caroom, MD; Robyn Rich- Accuracy ofReportingEstimatedBloodLossinOpenRepairPelvicand MS3-4 MORENO, TANIR Acetabular Fractures - - 119

ABSTRACTS Conclusion: With alopecia in African Americans now gaining recognition, a new issue arises regarding the amount of education Results: A survey A Results: was taken of 277 black women and of the 117 that did not seek care from any physician either a primary care provider or a dermatologist 27.35% said it was because they did not know a dermatologist could help with hair loss, 16.23% said it was because they did not believe that a dermatologist could help with their specific hair texture, and 8.55% did not have money , transportation or time to see a physician Of the patients who did receive care from a dermatologist 34.78% were unsatisfied with American Hair. African their physicians knowledge of Methods: This literature review and research survey intends to synthesize high quality research evidence. The medical aspect ad- dresses scientific strategies to prevent and American treat The population. alopecia psychosocial African specifically goal in is the designed to ascertain whether there is a knowledge disparity regarding alopecia in individuals from a variety of communities and be should factors socioeconomic and ethnic whether about questions thoughtful raises project the Ethically, backgrounds. economic considered during the educational period of medical school. Background: Alopecia is broadly defined as hair loss. It has historically been considered a cosmetic condition which means that most insurance companies do not cover the cost of This care. is problematic for those with lower socioeconomic status who either have no health insurance coverage or who cannot afford more expensive plans that could help to augment the costPatients do ofnot see alopecia treatment. as a purely cosmetic condition. especially Hair, among the U.S. female population is often associated with attractiveness, and fertility, If femininity. hair loss occurs, it not only detracts from perceived attractiveness, but it has been address the medical opportunities, the psychosocial barriers, shown and to the be ethical associated with a lower To quality of life. dispari- for solution and need a identify must community medical the survey, research and review literature this by posed dilemmas ties in dermatology. Bradley Osemwengie, E.L. Domingo-Johnson, Lance Mwangi, Dr. Anastasia Ruiz, Dr. Steven Berk Anastasia Ruiz, Dr. Lance Mwangi, Dr. Bradley Osemwengie, E.L. Domingo-Johnson, Alopecia in African Americans: A literature review Alopecia literature Americans: A in African School: School of Medicine MS3-4 OSEMWENGIE, BRADLEY Discussion: These cases highlight the importance of recognizing complications as well as adverse effects of treatment with long- judicious treatment are crucial in preventing permanent disability. term corticosteroids. Early diagnosis and Case 5: An 81-year-old male with type II diabetes and a history of armadillo contact presented with diffuse hypopigmented lesions hypopigmented diffuse with presented contact armadillo of history a and diabetes II type with male An 81-year-old 5: Case of 18 months. Case 4: A Case 57-year-old A 4: male with a history of previously treated leprosy presented with 6 months of diffuse burning pain that im- He developed avascular necrosis of the femoral head. proved with gabapentin and prednisone. Case 3: A 41-year-old male with a history of previously treated leprosy presented with erythematous nodular rash and fever that resolved with thalidomide. Case 2: A 20-year-old female with a history of previously treated leprosy presented with painful nodular rash and fever that im- glaucoma. She developed steroid-induced proved with corticosteroids. Case 1: A 39-year-old male presented with diffuse nodular rash and lagophthalmos of 8 months. He developed unilateral blindness. unilateral developed He months. 8 of lagophthalmos and rash nodular diffuse with presented male 39-year-old A 1: Case Case Presentations: Background: Hansen’s Disease, or leprosy, is caused by Mycobacterium leprae, an acid-fast bacillus that causes significant disease disease significant causes that bacillus acid-fast an leprae, Mycobacterium by caused is leprosy, or Disease, Hansen’s Background: of the skin, peripheral nerves, and eyes. the demonstrate cases Long-term These years. 5 last complications the in include Texas type West 2 in treated were that erythema leprosy lepromatous of cases 5 nodosum report leprosum, We blindness. neuropathy, and in the United States. and treatment of leprosy and its complications diversity of presentation Emily Nguyen; Ganesh Maniam; John Scott Milton, MD; Jack Waller, MD Waller, MD; Jack John Scott Milton, Ganesh Maniam; Emily Nguyen; MS3-4 NGUYEN, EMILY NGUYEN, MS3-4 Series Case A Panhandle: the Texas in (Leprosy) Disease Hansen’s

ABSTRACTS 120 diagnosis of Mycoplasma Pneumonia. With positive mycoplasma IgM on serology,a of on by course Pneumonia. IgM Withfollowed 5-day Mycoplasma mycoplasma Azithromycin a of positive diagnosis a with consistent were and history exposure infectious upon based obtained were Serologies strep. AGroup and fever Q tonella, Bar Tuberculosis, entericolitica, Tularemia, Yersinia Histoplasmosis, Coccidiomycosis, Mycoplasma, include to differential the widened that exposures fever.infectious developed possible father multiple his reported and Family nodosum, erythema and fever worsening erythema nodosum. Duringpatient’s disease course, histwobrothersandmother developed similar symptoms including trates in bilateral perihilar regions despite minimal respiratory symptoms. During admission, he continued to have daily fevers and infil- interstitial patchy CRP.revealed and CXR ESR elevated an with thrombocytosis and leukocytosis mild revealed evaluation Laboratory appearing. well overall but febrile was he admission, Upon forearms. and shins his on nodules tender erythematous of mune conditions, and malignancy. We report the case of a 9-year-old male who presented with a 10-day history of fever and 4 days IV type a to due autoim exposure, drug infections, fungal and bacterial are nodules children in hypersensitivity.causes delayed common most the of Some subcutaneous erythematous, tender, by characterized manifestation skin rare a is Nodosum Erythema *These authorscontributedequallytothiswork K. HigginsMS4*,M.RouseC.CooperMD,Strong MD,R.LampeJ. A Caseof ErythemaNodosuminMultipleFamilyMemberswithFeverofUnknownOrigin MS3-4 ROUSE, MARY School: SchoolofMedicine result ofanotherembryologicalstructureduringtheformationhindgut. the or remnant urachal a of variant a is mass the whether unclear is It studies. radiological and urological previous in upon lated extrapo been not had wall bladder the in region mass-like this that determined was it literature, the of review a completing Upon prior to comparison ultrasonography.in Nofurtherurologyinterventionormanagementwasplanned. size smaller slightly possibly or unchanged an showed ultrasonography follow-up, one-year recent most the remnant. At urachal a represent potentially may but cystic or malignant be to unlikely was structure the that concluded was It portion oftheurinarybladder. no evidence of the mass could be visualized on cystoscopy. Repeat ultrasound showed the stable intramural mass along the superior cystitis. focal versus pseudotumor inflammatory versus leiomyoma included considerations Differential follow-up, three-month At A subsequentpelvicMRIshowedstablesizeofthemassinvolvingbladderwallwithsignalcharacteristicssimilartomuscle. tic pathology, arepeat ultrasound wasdonetwoweekslater, whichshowedthepersistentabnormality in theanterior bladder wall. ages demonstrated a focal area of thickening in the anterior wall of the urinary bladder. Due to concerns of focal cystitis or neoplas- im- multiple kidney.addition, right In the of appearance normal and kidney left the in pelviectasis trace showed ultrasound Renal was unremarkable. exam physical The enuresis. or urgency,incontinence, denied but voiding with hesitation had patient The urethritis. possible and retention urinary of evaluation the for clinic Urology a to presented initially hydronephrosis left Aof history with 7-year-oldmale Abirami Rajasegaran Pseudo massoftheurinarybladder: A possibledevelopmentalvariant MS3-4 RAJASEGARAN, ABIRAMI School: SchoolofMedicine curriculum fortheseindividualsaswell. the in integrated be to need also they but practitioners, and students medical by out sought be to need only not population specific medical the this about knowledge in of Levels managed. be knowledge to ought they how of and conditions, about hair community and African level skin American the assess to conducted be to needs Research hair. and skin American African about is there Wilson MD - - - 121

ABSTRACTS - Methods: Charts of selected surgical burn patients were reviewed and categorized on the basis of surgery diabetic status to and whether prior they hours four least at stopped and (“fed”) surgery of hours four within to continued were feeds which in procedures had (“unfed”). Percent change in pre- and post-op BG levels were compared between groups. Rank-Sum Wilcoxon and Two-Sample testing were used for statistical analyses. Introduction: The hypermetabolic state experienced by burn patients post injury puts nutritional support at the forefront of these care. patients’ Enhanced After Recovery Surgery (ERAS) algorithms include a radical approach of feeding patients up to surgery with reported advantages like earlier recovery of GI function, among The others. purpose of this study was to assess perioperative at our institution. blood glucose (BG) levels in patients fed up to and through surgery Grant Sorensen, MS, PhD, Andrea Hess, Chloe Cooper, Brianna MSN, RN, FNP-BC, CWS, John Griswold, MD, FACS CNSC, Jennifer Kesey, Hope, PharmD, BCNSP, Landon Hope, Clayton Wagner, MS, Scott O’Banion, MS3-4 SORENSEN, GRANT MS3-4 SORENSEN, in Burn Patients Impact on Glucose Control Surgery, Feeding Through Tube Methods: A retrospective A Methods: chat review was performed in non-diabetic burn patients admitted during 2010-2018 with ≥20% TBSA inter at requirement insulin Absolute criteria. diagnostic ABA 2007 to according sepsis suspected for culture blood a obtained who Introduction: Early recognition of sepsis is the key step toward reducing morbidity and mortality in all patients. Burn patients were patients Burn patients. all in mortality and morbidity reducing toward step key the is sepsis of recognition Early Introduction: excluded from most major studies on sepsis because of challenges in identifying sepsis state and loss of in primary barrier to infection.1,2 burn Hence, there is no clear patients protocol for early recognition due of sepsis in burn patients.3 to hypermetabolic The hyperglycemia in burn patients is tightly controlled with daily insulin injections or intravenous drip.4,5 The American Burn Association (ABA) diagnostic criteria includes an increase in insulin requirement >25% over 24 hours of sepsis as an indication the aimed to exact of time determine possible if point sepsis.6 where However, the insulin requirement increase is We not evident. is a sensitive early indicator of sepsis. variation in daily insulin requirements School: School of Medicine Simran Singh, BS, MBA, Samudani Dhanasekara, MBBS, PhD, Nadia Tello, BS, MBA, Parker Southerland, BS, Adel Alhaj Saleh, Saleh, Alhaj Adel BS, Southerland, Parker MBA, BS, Tello, Nadia PhD, MBBS, Dhanasekara, Samudani MBA, BS, Singh, Simran Dissanaike, MD. APRN, FNP-BC, CWS, Sharmila MSN, MD, Jennifer Kesey, - There sepsis. of signs of development to prior hours 48 at increases requirement insulin daily the that show results Our Conclusion: a sensitive marker for diagnosis of sepsis in burn patients. fore, daily insulin requirement could be Can Variations in Insulin Requirements be an Early Indicator of Sepsis in Burn Patients? be an Early Indicator of Sepsis in Insulin Requirements Can Variations Results: Fifty-eight patients were included in the When study. daily insulin requirement was regressed on each 48, time 72, and 96 hours prior to obtaining points a blood culture) in a mixed effects(24, model including 96 sta- hours as the reference category, tistically significant positive effects were observed for 48 and 24 hours (β=22.432, SE=11.022, t=2.035, p=0.0434 and β=25.943, SE=11.022, t=2.354, p=0.0197, respectively). The increase in daily insulin 37.83%, respectively. requirement at 48 and 24 hours were 32.71% and MS3-4 SINGH, SIMRAN vals (24, 48, 72, and 96 hours prior to obtaining a blood culture) were analyzed using mixed-effects models accounting for within- time point. package in R in order to compare insulin requirement for each patient dependencies using the lmerTest School: School of Medicine School: School 10-day 10-day course of Doxycycline were given. Mycoplasma serologies were also obtained from showing the family, an patient’s IgM response from the older brother and an IgG response from all other family members. Despite persistent stable daily for discharge on day 17 fever, of illness patient with close infectious disease was follow up. While erythema nodosum alone due to any cause is relatively rare, cases of erythema nodosum in multiple family members simultaneously due to Mycoplasma infection has been of an unusual condition. a rare presentation cases to highlight present these We rarely documented.

ABSTRACTS 122 School: School ofMedicine was performed andappropriateantibioticswere given. pulmonary emboli which led to a large peri- pneumonic effusion. The patient’s symptoms improved once U/S guided thoracentesis septic developed patient continued. The was anticoagulation therapeutic thrombus, superficial demonstrated LUE of U/S The ing. swell- extremity of upper ROM L limited developed and patient’s declined the status 7, respiratory day On coverage. effective for vein. Blood cultures grew Fusobacterium spp, confirming the diagnosis of Lemierre syndrome. The patient was switched to Unasyn CTpain. jaw/neck left Lshowed neck jugular internal left the of portion inferior the occluding thrombus with abscess peritonsillar and dyspnea, pain, chest with febrile be to continued he status, euvolemic reached negative. patient fluenza was the test After A/B In- strep, beta Rapid Monospot, including up work positive. Additional FOBT ulcer, gastric bleeding non- and esophagitis reflux tiated. Shortly after admission, the patient was pancytopenic with critical thrombocytopenia s/p platelets transfusion. EGD showed hematemesis. On admission, his BP was 97/52 fluid responsive, tachycardic, febrile to 102.4. Vancomycin/Zosyn treatment was ini- Case: A 19- year- old male with no past medical history was admitted for worsening of sore throat, fever,chills, body aches, syncope, younger population,theproperdiagnosisofLemierre’s syndromecanbedifficult,delayingnecessarytreatment. the in pharyngitis benign of prevalence high a is there Because million.2 1 per cases 3.6 of rate incidence current a with tibiotics, an- of introduction the to due 1960s the in incidence in declined syndrome The 1 necrophorum. Fusobacterium to due commonly most emboli, septic and thrombosis vein jugular internal by complicated infection, pharyngeal persisting a by defined is syndrome properly.treated This or found not if life-threatening be can that condition disguised rare, a is Lemierre’ssyndrome Background: Ashley MaveddatMS3,Nikita Tangella MS3,RobertFoyMD,LeilaRubioEstherRobbinsMD The progression of tonsillitistosevere thrombophlebitis inayoungcollegestudent MS3-4 TANGELLA, NIKITA School: SchoolofMedicine blunt forcepenetratingbraininjurytothebilateralfrontalcortices. velocity low of sequelae the presents case This pad. a on writing via communicate to needed still but months, six within function motor of recovery full a made She hemiparesis. sided right and aphasia motor with eleven, day postop on discharged was Patient neck and abdomen, and a retained metal object in her skull. She was then taken to the OR for emergent laparotomy and craniectomy. a rare case of assault with a round metal knife sharpener. A 28 year old woman was brought to the ER with multiple stab wounds to attempts, and assault. PBI is potentially life threatening and suicide can have serious injuries, short and work-related long-term consequences. Hereby accident, we present car in seen still is it however, zones; war of outside rare is (PBI) injury brain Penetrating Caleb Stewart,Elmira Ahnood Stabbing With aBluntObject: A Rare CauseofPenetratingBrainInjury MS3-4 STEWART, CALEB School: SchoolofMedicine outcomes. patient superior with associated been patients. has burn management of BG better workup since investigation further worth is This perioperative to related practices guide could nutrition perioperative using control BG Improved healing. promote and plications com- prevent to critical is post-op ranges BG Controlling literature. ERAS with line in are findings These group. pre-diabetes the Conclusions: Our data shows better BG control in fed procedures with lower percent change from pre-op to post-op overall, and in levels from24-hrpre-opto12-andpost-opinthepre-diabetesgroup(p=0.021p0.026,respectively). BG in change percent the in difference significant statistically a was There respectively). 0.009, = p and 0.014 = (p status diabetic in BG levels from 24-hr pre-op to 12- and 24-hr post-op in the unfed vs. fed groups across all procedures, prior to grouping based on largerprocedures. significantly fed a change 92 was percent and There unfed 106 with patients 32 yielded collection Data Results: 123

ABSTRACTS - - - . tion after undergoing bilateral carotid artery stent placement and treatment for a left frontal lobe stroke who subsequently developed subsequently who stroke lobe frontal left a for treatment and placement stent artery carotid bilateral undergoing after tion otalgia and a clicking sensation when turning her head. The CT obtained upon her initial presentation styloid elongated the to due presentation, atypical an Although for processes. styloid elongated bilateral have to noted and re-evaluated stroke symptoms was processes and active the symptoms, patient’s it was decided that the benefits of an exploratory surgery were warranted in order to of relief to led which sides both on styloidectomy underwent subsequently patient The styloidectomy. of need potential the evaluate her ongoing The symptoms. neurological findings of this patient upon initial presentation are atypical for the classic case of Eagle is of benefit to approach is not novel, we believe that this unique presentation plan and surgical our treatment Although Syndrome. the further understanding and work up of Eagle Syndrome. In conclusion, we deem it appropriate to consider Eagle Syndrome in the differential in a patient presenting with obstructive or stenotic carotid pathology School: School of Medicine Eagle Syndrome occurs in approximately 4% of the population and is commonly asymptomatic. This disease occurs secondary to head- head, the turning when sensation clicking a dysphagia, like symptoms causing processes, styloid both or one of elongation the evalua female who presented for ENT ache, otalgia, and other cervical symptoms. Here we present a unique case of a 43-year-old Nicole Van Spronsen BS, Rahul Varman MD, Joehassin Cordero MD FACS Varman Spronsen BS, Rahul Van Nicole Eagle Syndrome: An Atypical Neurological Presentation An Eagle Syndrome: MS3-4 VAN SPRONSEN, NICOLE SPRONSEN, MS3-4 VAN Lisfranc fracture dislocations are often the result of high-velocity traumas. In our case, a large bull stepped on the patient’s foot dur foot patient’s the on stepped bull large a case, our In traumas. high-velocity of result the often are dislocations fracture Lisfranc American bull riding is the most dangerous organized spectator sport in the world.Head, shoulder, and knee injuries are the most common, and 36% of injuries to bull riders are considered severe. Fractures are the most common severe While injury. Lisfranc open Lisfranc production, career on effect minimal have generally and athletes elite in common somewhat are dislocations fracture with little documentation of recovery and return to elite competition. fractures from sport are much less common, Jonathan Umelo, BS; Stephen Sierra, MD; Kevin West, MD; Christopher Lee, BS; Matthew Ferguson, MD Ferguson, MD; Christopher Lee, BS; Matthew West, Kevin Jonathan Umelo, BS; Stephen Sierra, MD; Unusual Mechanism and Duration of Injury of an Open Lisfranc and Fracture Other Open Foot in Fractures a Bull Professional Case Report A Rider – MS3-4 UMELO, JONATHAN MS3-4 UMELO, School: School of Medicine School: School of Medicine School: School of Medicine ized pustular eruption accompanied with systemic symptoms and (i.e. chills) pain, and fever, lab abnormalities (hypoalbuminemia and hypocalcemia). Because of its varied clinical presentation, it is important rule out Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) from the psoriasis. differential.pustular Here,generalized acute we of presentdiagnosis a theto caseleading ofultimately TEN, aout 72-year-oldrule manto presentingrash toof history our2-week dermatology a for service consult ing a competitive event, resulting in an open left foot first metatarsophalangeal dislocation and Lisfranc fracture/dislocation along with comminuted fractures of the second through fifth metatarsals and cuboid. This injury is much more severe than the Lisfranc injuries among professional athletes documented in other studies, and therefore the road to recovery and return to competition is notable. Generalized Generalized pustular psoriasis is a rare subtype of psoriasis that can present in a variety of clinical manifestations. Of the different classifications of generalized pustular psoriasis, acute generalized pustularpsoriasis (AGPP), also known as von Zumbusch pso- riasis, is one of the most severe variants and may be fatal without This appropriate treatment. form typically presents as a general Timothy Tran MS, Daniel Baird MD, Brent Austin MD, Ashley Sturgeon MD Sturgeon Ashley Austin MD, Baird MD, Brent MS, Daniel Tran Timothy MS3-4 TRAN, TIMOTHY TRAN, MS3-4 Psoriasis Pustular Case of Generalized A

ABSTRACTS 124 School: School ofMedicine keep rarecausessuchasHHV-6 on the differential. to important is unclear,it is agent causative the which in meningitis viral HHV-6of of cases diagnosis In meningitis. the supports other viral etiologies; this evidence, along with the marked any clinical improvement upon administration of gancyclovir for to the patient, negative HHV-6 while for times both positive be to found and patient our on twice performed was test the case, specific Conclusion: Successful recognition and treatment of HHV-6 meningitis requires exclusion of more common viral etiologies. In this on theirtestresultsinthecontextofclinicalpicture. tests are not routinely available at most hospitals. Therefore, diagnosing HHV-6 meningitis requires that clinicians must instead rely ciHHV-6 between HHV-6 differentiate these true to - but and needed are meningitis tests specific population, the of 1% in present DNAviral the of detection However,PCR sensitive. DNAthat 92% viral found was integrated chromosomally since (ciHHV-6) is Discussion: It is certainly appropriate to question the validity of HHV-6 testing in this case, but a study of HHV-6 diagnostic assays from hercomabyday14ofinpatientganciclovir. emerged gradually then ganciclovir,and IV on started HHV-6.therefore only was for Patient positive tested PCR and pleocytosis of antiepileptics, but was followed by a postictal coma. An MRI and cardiac testing were both negative. A lumbar puncture revealed lucinations. An EEG showed significant abnormalities suggesting temporal lobe seizure activity, which resolved with administration Case Report: : A 62-year-old female presented to the hospital with status epilepticus and altered mental status, including visual hal- with intheirchildhood.However, thispaperpresentsararecaseofHHV-6infected meningitisinanadultpatient. subclinically been have individuals most which herpesvirus, common a (HHV-6)is 6 herpesvirus Human Introduction: Ganesh Maniam,MSIII;Hannah Wilkerson, MSIII;Dr. ScottMilton,MD An Adult PatientwithHumanHerpesvirus6Meningitis MS3-4 WILKERSON, HANNAH School: SchoolofMedicine arthritis waslikelyafactor. The bullouslesionsbegantoimprovewithadministrationofhigh-doseprednisone. rheumatoid of patient’shistory the thus disorders, autoimmune malignancy,and disease, hematologic with patients in seen is ant vari- This cells. mononuclear histiocytoid of infiltrate inflammatory an shows Sweet’swhich histiocytoid syndrome called variant to develop on the upper extremities. A second punch biopsy was consistent was a diffuse neutrophilic dermatosis, specifically a rare medium vessel vasculitis, though p and c-ANCA were negative. suggested Over biopsy the Initial course of findings. the physical patient’s on based hospital diagnosis stay,differential the new leading lesions pemphigoid continued bullous and eruption drug lous bul- with consulted, then was Dermatology SJS. was this that likelihood the reducing desquamation, skin no was there however, tongue, the of base the at patient’sand the extremities on demonstrated were bullae hemorrhagic tender examination, physical On renal disease on hemodialysis, coronary artery disease, hypertension, hypothyroidism, hyperlipidemia, and type II end-stage diabetes mellitus. arthritis, rheumatoid included history medical past Relevant symptoms. additional notable were conjunctiva thematous ery- and pain, joint diffuse Pruritis, placement. stent after administration Plavix to secondary (SJS) syndrome Stevens-Johnson for We present an atypical case of Sweet syndrome, in which a 71-year-old female was initially transferred to our service with concern neck inadditiontofever, myalgia,andarthralgia. Women ages 30-50 are the dominant demographic. Typical features include tender papules and nodules on the extremities, face, and Its etiology is often idiopathic, though it is linked to underlying malignancy, allergies, and inflammatory and autoimmune disorders. Sweet syndrome, a neutrophilic dermatosis, is a dermatologic condition characterized by a neutrophilic accumulation in the dermis. Walterscheid, Brooke,EshakM.D.,Nouran, Tarbox M.D.,Michelle Atypical presentation ofhistiocytoidSweet’s Syndrome MS3-4 WALTERSCHEID, BROOKE 125

ABSTRACTS SCHOOL OF NURSING School: School of Nursing Treatment of Adolescents with Traumatic Brain Injury Adolescents with Traumatic of Treatment NURSE MICHELLE KUTCHA BSN, RN & SHANDRAE RUNNELLS BSN, RN BSN, RN & SHANDRAE RUNNELLS BSN, NURSE MICHELLE KUTCHA School: School of Nursing NURSE ELANA SHERWOOD & JANELLE CALLOWAY & JANELLE SHERWOOD NURSE ELANA Abuse Disorder Adolescent Substance Best Practice: School: School of Nursing BRCA Gene and Breast Cancer Gene and Breast BRCA NURSE SAMREEN ALI & GABRIELA PETROZZI NURSE SAMREEN ALI & GABRIELA School: School of Medicine Flow cytometry (FCM) immunophenotyping, is an important tool in biomedical research to study diseases, discover treatments, discover treatments, research to study diseases, tool in biomedical is an important (FCM) immunophenotyping, Flow cytometry neoplasms, hematological such as diseases monitor prognose, and diagnose, to clinically utilized be could that panels develop and immunodeficiency, and organ transplantation. However, developing FCM panels in mouse modelsin innate immunity that cells critical phagocytic (MOs). populations including macrophages analyzing rare immune MOs are large is difficult, especially when are polarized as M1 pro-inflammatory or M2 They anti-inflammatory. are importantin chronic diseases such asasthma, atherosclerosis, rheumatoid arthritis, and Thus, transplantation. organ in this study we developed a FCM panel characterizing M1 and M2 and mouse peritoneal First, primary model. our transplantation models including mouse to many primary applies mouse MOs that voltages and titrated were antibodies FCM corresponding the and vitro, in M2 or M1 as polarized isolated, were MOs marrow bone weoptimized. gatedBriefly, on single cells, followed by live cellsT-cells, (excluding dendritic dead cells, cells,B-cells, granulo- 50.83% were there population, only M1 the Of monocytes. and MOs M2 and M1 as gated further were which MOs then and cytes) M2 CD206+Arg-1- 59.44% and MOs M2 CD206+Arg-1+ 40.10% were there population, only M2 the Of MOs. iNOS+CD38+M1 popu- MO M2 or M1 either of that to profile similar a resembled it identified, and mixed were MOs M2 and M1 when Finally, MOs. lations alone, indicating that the panel can correctly identify M1 and M2 MOs from a mixed Therefore, population. this panel was innate analyze to grafts transplanted and blood, peritoneum, nodes, lymph spleens, mouse in MOs M2 and M1 characterize to used immune responses generated post transplantation. Based on these data, this panel can be utilized in all types of mouse models to and will improve studies of diseases in which MOs play crucial roles. analyze primary M1 and M2 MO populations Kandis Wright PhD, Brian Reilly PhD, Gurvinder Kaur PhD, and Jannette Dufour PhD and Jannette Dufour Gurvinder Kaur PhD, Brian Reilly PhD, PhD, Wright Kandis MS3-4 WRIGHT, KANDIS WRIGHT, MS3-4 - has vast ap mouse tissue that primary in and monocytes macrophages of M1 and M2 polarized immunophenotyping Multi-color transplantation mouse models including plication in

ABSTRACTS 126 School: School ofNursing Treatment ofInfantswithCommunity Acquired Pnewumonia NURSE MARY KATHERINE RICHEY, JOSHUA SMOTHERMON, &ERICAWALKER School: SchoolofNursing Preoperative EducationDescrease Anxiety NURSE DANIELLE ARGUELLO, TIFFANY ELDER,&LAURA LOZANO School: SchoolofNursing Pneumothorax NURSE AUTUMN KAINES, MACKENZI LAIN, KEVINBARKER, LAUREN BROWN, &MIRANDA COCHRAN School: SchoolofNursing Corneal Abrasion ManagementGuidelines NURSE MATT ELLIS&TROY FAULKNER School: SchoolofNursing Management ofIncreased IntracranialPressures HypertonicSalinevsMannitol NURSE KENIAMARTINEZ-FLORES &SANDRAAREVALO School: SchoolofNursing Appraising theEvidence:Cargiver Fatigue NURSE CLAIRECHAMPION&JACQUELINE SWINEY School: SchoolofNursing Preventing UTI’s inPatientswithLongTerm IndwellingUrinaryCatheters NURSE ALEXANDRIASMITH&CANDACE FLORES School: SchoolofNursing Implantable Cardioverter Defibrillators:TheirImpactonQualityofLife NURSE ASHLEYJAMES, BSN, RN&JULIEVEREEN, BSN, RN 127

ABSTRACTS - RESIDENTS & CLINICAL FELLOWS School: Texas Tech University Health Sciences Center University Tech Texas School: tigue, lymphadenopathy, night sweats, bloody stool, or other malignancy related symptoms, but has recently had a 7 pound weight night sweats, bloody stool, or other tigue, lymphadenopathy, scale involving the entire forehead, nose, loss in 6 months. Physical exam revealed a confluent 1 cm thick brown hyperkeratotic along with numerous budding yeast forms and medial cheeks. Punch biopsy of the left cheek showed massive hyperkeratosis with hyperkeratotic seborrheic dermatitis. She within the stratum corneum. Given these budding yeast forms, she was diagnosed 150mg and ketoconazole shampoo with weekly diflucan Treatment has refused all lab tests and work-up for internal malignancy. along with 20% urea cream resulted in marked improvement within two months. 2x weekly, 79 year old presents with a history of an asymptomatic scaly eruption on face for 4 years. She denies other symptoms such as fa 79 year old presents with a history of an asymptomatic scaly eruption on face William Boothe William Massive facial hyperkeratosis resembling severe ichthyosis diagnosed as seborrheic dermatitis ichthyosis diagnosed as seborrheic severe Massive facial hyperkeratosis resembling R&CF BOOTHE, WILLIAM R&CF BOOTHE, School: School of Nursing Triple Therapy vs. Monotherapy - Emphysema Triple School: School of Nursing RN BSN, MARTIN, C. RN & CHRISTOPHER BSN, MCCARTY NURSE SCOTT Treating Depression in Perimenopause: Hormone Therapy, SSRI or Both? SSRI or Both? Hormone Therapy, in Perimenopause: Depression Treating NURSE AUDRA ELLIS & TIFFANY JACKSON ELLIS & TIFFANY NURSE AUDRA School: School of Nursing School: School NURSE ANGELA LETBETTER & BRITTA MAXWELL BRITTA & LETBETTER ANGELA NURSE Mortality Infarction Myocardial Symptoms and Presenting

ABSTRACTS 128 School: Texas Tech UniversityHealthSciencesCenter mal evaluationshouldcontinue tobeinvestigatedfornewfindingsthatmightaidindiagnosis. nor initially an despite pain persistent that reminded are Providers broad. be should differentials early that demonstrates case This leukemia. with consistent t(1:19), translocation a revealed studies chromosomal and cytogenetic Further blasts. 21% with hypercellular was limits and the time from initial symptoms to diagnosis can take two weeks longer or more. In the present case, bone marrow biopsy normal to close or normal within often are counts blood feature, presenting primary a as pain bone with patients In anemia. cytic commonly hypercalcemia; however, our patient’s laboratory values were within normal limits with the exception of a mild normo- The radiographic finding of lytic bone lesions in acute leukemia is frequently accompanied by other laboratory abnormalities, most lesions wererevealedandledphysicianstobroadenthedifferential toanoncologicalprocess. home. It was notuntil an MRI wasdone at the third ED visit (due to his persistent pain despite normal x-rays) that focal lytic bone patient was diagnosed with hip strain both times, as he is an avid basketball player and advised to manage the pain conservatively at The noted. were findings acute no and x-ray via imaged was he department emergency the to presentations separate two During to theemergency roomwithpredominantlynormalbloodcountsandmultiplex-rays. visits several and limping pain, hip of months after leukemia lymphoblastic acute B-cell with diagnosed ultimately was who male 15-year-old a of Wedelayed. case is the that present diagnosis a often is leukemia pain, hip and/or limping with present that tions A relatively common presentation of acute leukemia in the pediatric population is a limping child. Given the typical range of condi- Brittany CoxMD;ChibuzoO’SuojiMD B-cell acutelymphoblasticleukemiapresenting withfocallyticlesionsandinitiallynormalbloodcounts R&CF COX, BRITTANY School: Texas Tech UniversityHealthSciencesCenter early andappropriatediagnosisofararetumordespiteconfoundingfindings. Lindau disease. Our case highlights the importance of clinical findings being combined with laboratory and imaging findings for the certain genetic syndromes such as, but not limited to, neurofibromatosis type 1, multiple endocrine neoplasia type 2 or Von Hippel- 2-5 in occurring rare, relatively are people per tumors million, and only 10% These of cases occur in symptoms. children. Pediatric cases are other more likely to be among hereditary, sweating and are associated with and headaches, loss, weight hypertension, cause can which norepinephrine) and (epinephrine catecholamines secrete and gland adrenal the from arise Pheochromocytomas VMA, andMRIshowingsuprarenalmass,confirmingthediagnosisofpheochromocytoma. metanephrines, MRI, echocardiogram, and electrocardiogram. Work-up was negative except for elevated urine norepinephrine and murmur. Work-up CMP,differential, with CBC assessment, HEADSS full included urine studies, thyroid urinalysis, culture, blood more and seemedto be dieting. On exam, patient was foundto be febrile, hypertensive, tachycardic with bounding pulses and new exercising been had he family’sreport per however dysmorphia, body or emesis intentional denied He sweats. night and attacks, A 13 year old male presented to the ED with vomiting and 15 pound weight loss over the past 18 months. He reported frequent panic Blayne Street,DO;ClaireCooper, MD; Andres Ruiz,MD; Alexandra Townes, MD Putting thePiecesTogether: A Teenager withUnexplainedWeight Loss R&CF COOPER,CLAIRE - 129

ABSTRACTS - gery. gery. School: Texas Tech University Health Sciences Center University Tech Texas School: Urinary retention is a common urological presentation, due to bladder outlet obstruction or neurogenic bladder in majority of cases. of majority in bladder neurogenic or obstruction outlet bladder to due presentation, urological common a is retention Urinary present a Our series case of re- cases that suggests a novel association between methamphetamine use and neurogenic bladder. We ports include patients that presented with acute urinary retention and documented methamphetamine use without other identifiable etiology for urinary retention. Anas Hamdi , MD, James Cammack, MD R&CF HAMDI, ANAS bladder. case series suggesting a novel association between Methamphetamine use associated with neurogenic A School: Texas Tech University Health Sciences Center University Tech Texas School: Cerebral phaeohyphomycosis is infection of the central nervous system (CNS) by dematiaceous fungi. Most common mechanisms common Most fungi. dematiaceous (CNS) by system nervous central the of infection is phaeohyphomycosis Cerebral of infection are by direct extension cerebral via the acquired paranasal who sinuses disease or preexisting hematogenous spread. any The without mortality rate man is young high a and ranges describes from case Our topic. this on studies limited the in 50%-79% phaeohyphomycosis following nasal inhalation of garden mushrooms. Despite aggressive therapies, he ultimately died due to this of our literature review of this deadly infection. severe infection. Our case report discusses our treatment approach and the results Christopher Daniele, Miriam Ferguson, Cooper Phillips, Jinesh Lachmansingh, Jacob Nichols, John Fisher, Brady Holstead, Ak- wasi Opoku R&CF DANIELE, CHRISTOPHER R&CF DANIELE, case report A phaeohyphomycosis: Novel origin of cerebral School: Texas Tech University Health Sciences Center Tech Texas School: Conclusions: Glycemic control is not significantly associated with increased extremity HbA1c surgery. should riskbe included as of complicationsone element of the in surgical preparedness electivealgorithm, rather than an hand and upper independent disqualifying factor. Background: Background: Studies addressing the utility of A1c hemoglobin (HbA1c) levels in predicting surgical complications have reported The surgery. elective for eligibility patient’s a determine to cutoffs HbA1c traditional use surgeons many practice, In results. mixed sur factor in elective hand and upper extremity limited in evaluating HbA1c as a risk literature is especially Results: Subsequent analysis revealed no significant correlation of elevated HbA1c levels or DM with increased risk of postopera- tive complications. Cameron Cox, BBA; Stephen Sierra, MD; Alec Egan, BS; Desirae McKee, MD Alec Egan, BS; Sierra, MD; Cox, BBA; Stephen Cameron Patients and Methods: We performed a chart review of patients who underwent these elective operations performed at a surgeon The single outcomes institution. by of were 930 collected, surgeries 334 of which had pre or postoperative HbA1c a levels single and complication rates. between diabetes mellitus (DM) were reviewed for association All 930 surgeries recorded. gery complications postoperative of risk with levels HbA1c elevated of association the evaluate to aims study This Questions/Purposes: upper extremity surgery. in elective hand and R&CF COX, CAMERON COX, R&CF Sur Associated with Risk of A1c Postoperative Is Complications Not in Elective Hand Elevated and Hemoglobin Upper Extremity

ABSTRACTS 130 ventions this increased to 69%. Significantly, special cause variation was seen in the rate of overall breastfeeding in conjunction in breastfeeding overall of rate the in seen was variation cause Significantly, special 69%. to increased this ventions inter four following 41%, about was visit week 2 the at breastfeeding exclusive of rate average an showed data Baseline Results: intervention cycle.Outcomes thatwereassessedincludedthoseexclusivelybreastfeeding orcontinuedbreastfeeding. each for visit week 2 the at review chart through patients from collected was counselor. Data lactation certified a by residents for session teaching 4) and mother, each with through go to residents template check weight standardized (3) mother, breastfeeding the assist could members family ways detailing handout (2) life, of month 1 and week, 1 days, 3 and 1 at size stomach newborn of depiction visual (1)a of consisted Interventions clinic. care of continuity pediatric the at visit newborn week 2 their had and check, weight UMC a stay,attended NICU a Center,without Medical University at delivered patients at aimed was study The Methods: exam by15%overthespanof6months. evaluated at their 2 week exam. Our aim was to increase the rate of exclusively breastfed infants evaluated at the 2 week well baby is infant the time the by together all breastfeeding stopped or formula with supplementing started often have period newborn the Background: breastfeedingin start who mothers documented,many well are infancy breastfeedingduring of benefits the Although Sonia DurhamMD,KelseaLoveless-HoffmanLisa Pomeroy MD,BrianKirstenRobinsonMD Expanding theLongevityofExclusivelyBreastfed Infantsatthe2Week Well Visit R&CF LOVELESS-HOFFMAN, KELSEA School: Texas Tech UniversityHealthSciencesCenter “no-shows” atthementalhealthclinics. sages or phone calls prior to scheduled appointments; and effective communication between providers to help reduce the number of or mes- text of form in reminders auto-generated of use clinics; health mental of vicinity in especially services transportation aided insurance transport public improved rates- no-show the improve to recommendations several have Authors the findings the on Based appointments. initial their out miss to patients for reasons common the of some were patients and providers between tions communica effective of lack and forgetfulness friends, or family on dependence transportation, suggested study The Conclusion: at timeofscheduledappointment. subject was too sick to come for appointment Twenty-six, 86.6% subjects reported that they had full access to healthcare insurance one only survey,however phone of time at co-morbidities medical reporting 36.7% participants, eleven of total scheduled Aappointments. their missing for of contributors day major the on one overslept as transportation or reporting appointments 23.3% their subjects, seven about Another appointments. forgot they that reported subjects 33.3% subjects, ten participants, thirty total the Of compliance. appointment their for friends and family on dependence reporting % 36.7 subjects, eleven of Results: Atotal using descriptive statisticsinformoftablesandgraphs. out carried was analysis Data services. outpatient psychiatric the utilizing not for reasons the out find to interview” phone males from ages 3 to 77 years, who did not show up on their initial scheduled appointments. Patients were called using “structured fe- 14 and males 16 were survey.participants the Study in participated subjects only30 and no-shows of month in with out called were subjects 100 of total clinic. A psychiatry outpatient run resident based university the at conducted was study The Methods: not showingupontheinitialappointmentatanoutpatientpsychiatryclinic. towards contributing factors and reasons the identify to conducted was study The no-shows. for reasons likely more are tionnaire psychiatric readmissions to the hospital (Koch & Gillis, 1991). It has been hypothesized that common factors listed in survey ques- consistent and effective mental health treatment. Patients with many no-shows have a two-to-three times fold increase in the rate of to barrier significant poses which clinics, most for occurrence common is appointment initial an to appear to Failure Introduction: health caresetting. urban an in appointments out-patient psychiatric of non-compliance influence that factors potential the ToInvestigate Objective: Department ofPsychiatry M.D, BaroniaRegina Wakefield, Sarah M.D1, Dr. Sullivan Zachary D.O1., Kumar, Manish M.D1., Dareen Fred, Ruiz, Anastasia M.D., Bayazit Huseyin, A phonesurveyofno-showsinanurbanpsychiatricoutpatientclinic R&CF KUMAR,MANISH - - 131

ABSTRACTS . Methods: Team utilized Methods: Powerchart Team to review the vital signs of all patients above the age of 3 seen in the outpatient setting at the clinical site. If the blood child’s pressure met the cutoff for further evaluation AAP (per guideline), note child’s was examined to had which BP elevated with children of percentage the examined then We way. any in addressed or of note taken was BP the if see Design: Project designed to address the key drivers behind the issue of documentation of hypertension and communication in multidisciplinary the and pediatric reference of outpatient ease education, provider increasing of drivers key the on focused We setting. designed interventions with the goal of increasing documentation of hypertension in pediatric population ages 3-18 in outpatient setting by 20% in 3 months. Introduction: The American Academy of Pediatrics (AAP) released a clinical practice guideline in 2017 which cited the prevalence the cited which 2017 in guideline practice clinical a released (AAP) Pediatrics of Academy American The Introduction: of HTN at 2-4% in children and pressures blood adolescents setting outpatient pediatric and the In prehypertension years. in age prevalence child’s at the on 14.8%. based evaluation The further AAP require which guideline pressures blood also provides cutoff by way any in addressed not routinely is hypertension pediatric However, 3. of age the above or at children all on done typically are the primary care physicians in the documentation. Moheb Milad, MD Improving Hypertension Identification Rates in Outpatient Pediatric Clinical Setting Improving R&CF MILAD, MOHEB R&CF MILAD, School: Texas Tech University Health Sciences Center Tech Texas School: Conclusion: Coronary slow flow due to testosterone replacement needs to be investigated further Conclusion: Coronary slow flow due to Discussion: An Frequent undiagnosed phlebotomies disease may have helped avoid this complication of testosterone replacement. to the elevated hemoglobin. such as sleep apnea could have contributed Case Summary: A Case middle-aged A Summary: man with past medical history of low testosterone came in because of a headache he has had for days. He had diarrhea for a few days and woke up with chest pain in the morning that lasted a few minutes, no radiation, and pres- 146/93. was admission on pressure blood His diaphoresis. with associated was pain chest The pain. chest has longer no but like sure EKG showed J-point elevation in precordial leads and III but no The acute troponin ischemia.. was 60.1 on admission and went to 129.6 in hours. The about hematocrit 11 was 55.3. The patient was started on 150 ml/hr NS. The patient had a coronary artery an- with diagnosed was patient The disease. artery coronary no and showed slow flow diffusely it and day next the performed giogram Testosterone performed. was phlebotomy no so 50.5 to improved Hematocrit suspected. was viscosity hyper and flow low coronary was patient The 2.9. was erythropoietin and 5.32 was and weeks 6 about for testosterone off being after later month a measured was amphetamine and benzodiazepine positive. Introduction: Testosterone Introduction: causing Testosterone slow flow in the coronary arteries isnot wellTestosterone documented. increases hematocrit, a setting including methods by several hematocrit increase can Testosterone in blood viscosity. with an increase which is associated takes arteries coronary the in blood the where is flow slow Coronary marrow. bone the stimulating and point set erythropoietin new coronary stenosis. more time to move in the absence of significant Shane Metzler, MD, Mohamed Elmassry, MD, John Kelley, Ty Whisenant, MD, Drew Payne, MD Whisenant, MD, Ty MD, John Kelley, MD, Mohamed Elmassry, Shane Metzler, Testosterone Replacement Can Send You to the Cath Lab to Replacement Can Send You Testosterone R&CF METZLER, SHANE R&CF METZLER, School: Texas Tech University Health Sciences Center University Health Tech Texas School: Conclusion: Conclusion: The compounding effectof all interventionsin the nursery setting seemed to make the most profound continuation difference of in overall and exclusive breastfeeding at the two week visit, employing visual and auditory forms of education learning. provided appeared to be The most effective by all targeting involved family members in addition tothe physicians that were the education. providing with formula feeding following the four interventions. four interventions. the following formula feeding with

ABSTRACTS 132 School: Texas Tech UniversityHealth SciencesCenter acute painsymptoms, OMMcanfunctionas anadjunctivetreatmentfor the evaluationofefficacy ofmedicaltherapy symptoms of irritability, and decreased sleep; these factors may all contribute to prolonged hospitalization. In a bipolar patient with exacerbate pain, musculoskeletal cause can that behaviors high-risk with association inherent an has disorder Bipolar Discussion: able toappropriatelyassessthe efficacyoflithium. decrease in musculoskeletal pain with subsequent improvements in sleep led to decreased irritability, such that the physicians were This lithium. with co-treatment with manipulation soft-tissue on focusing treatments (OMM) medicine manipulative osteopathic four had patient the hospitalization, of week fourth his During symptoms. his control to failed olanzapine and valproate including medications psychotropic multiple of trials hospitalization, 6-week his of course the Over pain. patient’smusculoskeletal the trol con- to failed patches lidocaine transdermal and acetaminophen, oral NSAIDs, oral of symptoms. Administration extrapyramidal off a bridge. Upon admission for his mania and neck pain, he was started and titrated on risperidone, however, he acutely developed Case: A 64-year-old male with a past medical history of bipolar I disorder presented to the ED in an acute manic state after jumping management. medication of efficacy the evaluate to response pain decreasing by treatment, medical in aid to physically body the manipulating on focus help can principles Osteopathic medications. psychotropic of effects positive the mask can irritability and sleep poor ing history, psychiatric significant a with patient a In Introduction: caus- pain musculoskeletal whether to distinguish difficult be can it Panna PatelDO, Trisha Modi MSIII The EffectsofOsteopathicManipulativeMedicineasan Adjunctive Treatment inBipolarPatientsStrugglingwith AdequateSleep R&CF PATEL, PANNA School: Texas Tech UniversityHealthSciencesCenter immunosuppression, andhehasrespondedwelltooralitraconazole. for work-up unremarkable an had patient Our microflora. human the of constituent commensal harmless a considered generally is patients with uncontrolled diabetes mellitus type II including the case due to Cryptococcus albidus. Generally, Cryptococcus albidus Cryptococcus albidus, Cryptococcus uniguttulatus, and Cryptococcus laurentii. Of the four cases, three were immunocompromised to date shows four cases of onychomycosis secondary to Cryptococcus species. These four cases include Cryptococcus friedmannii, temic infections and 10-15% of skin infection. The most common pathogen is Cryptococcus neoformans. A review of the literature causing onychomycosis in an immunocompetent host. In immunocompromised patients Cryptococcus accounts for 33-55% of sys- subse- terbinafine, oral quently found of to have courses Cryptococcus albidus six-week on nail 2 fungal culture. to Torefractory our onychomycosis knowledge, this with is the male first reporthealthy of Cryptococcus33-year-old albidus a of case a Wereport Jeannie Nguyen,MD,E.L.Domingo-Johnson, Andres Garcia,MD, Ashley Sturgeon, MD Report ofaCaseOnychomycosissecondarytoCryptococcusalbidusandReviewtheLiteratur R&CF NGUYEN, JEANNIE School: Texas Tech UniversityHealthSciencesCenter final interventionsandcollectinganalyzingthedata. the implementing of process the in Wecurrently addressed. are issue the had pressures blood elevated with 3-18 ages patients on Results: Data collection and interventions are still ongoing. However, initial data collection showed that only about 5% of the charts nursing staffwiththesamereferences. ThenimplementingamechanismfornursingstafftoinformphysiciansofelevatedBPs. the Providing references. cutoff pressure blood the to access with physicians providing included Interventions addressed. issue the e . 133

ABSTRACTS - - More recently, dystonia has been redefined as uncontrollable muscle contractions, that can cause aand result involuntarily, in person’srepetitive movements, bodyor abnormal positions. The etiology partsof this condition is tonow categorized by two twist The firstaxes. axis includes clinical features such as age of onset, body distribution of the condition, temporal pattern (referring to tal conditions (carbon monoxide, viral infection, and levodopa antagonists). Since Dystonia was first coined by Oppenheim in 1911 as “dystonia musculorum deformans,” or hypotonic muscle in one instance, one in muscle hypotonic or deformans,” musculorum “dystonia as 1911 in Oppenheim by coined first was Dystonia Since categorized was Dystonia Initially, evolved. has condition this of classification the movement, upon another in hypertonic then and into two groups following the First International Dystonia Symposium in 1975; the first was primaryenvironmen to dystonia,due dystonia whichwas second referredthe and to neuroferritinopathy), and Wilsons, (Huntington’s, was condition the heritable how Ashish Sarangi MD PGY3, Domingo El-Johnson MS3, Lance Mwangi MS3 R&CF SARANGI, ASHISH Anticholinergics Dystonia and Management in Patients with Hypersensitivity to Use of concentrates is not only concerning due to its high THC potency and its association with adverse physiological effects (Zuur effects physiological adverse with association its and potency THC high its to due concerning only not is concentrates of Use Anastasia Ruiz, MD; Jennifer Phan, BS; Manish Aligeti; Jessica Nelson, MD; Sarah Wakefield, MD. Wakefield, Aligeti; Jessica Nelson, MD; Sarah Manish Anastasia Ruiz, MD; Jennifer Phan, BS; Not Your Grandma’s Marijuana – An Investigation into Cannabis Concentrates Marijuana – Grandma’s Not Your R&CF RUIZ, ANASTASIA R&CF RUIZ, School: Texas Tech University Health Sciences Center Tech Texas School: In the wide usage of cannabis in patients presenting for psychiatric care, it is important to obtain details of the type of cannabis being cannabis of type the of details obtain to important is it care, psychiatric for presenting patients in cannabis of usage wide the In counseling on the potential dangerous effects of cannabis concentrates. used, and to provide information and School: Texas Tech University Health Sciences Center University Health Sciences Tech Texas School: doses high administered those in observed been have hallucinations and anxiety, paranoia, effects; “psychological 2009), al., et man toxicity causing product BHO final the into way their find impurities that concern a also is It al.,2018). et A. Kelly (Sagar, THC of J et al, 2017). (Raber JC et al, 2015)(Meehan-Atrash Needle stick injuries are a potential occupational hazard of working in the thesehealth injuriescare comefield. with However, - as sociated financial and psychosocial it issues. is Firstly, estimated that the cost of a single needle stick injury is $500-$4000. Costs will some but tests, different 3 includes HIV HCV. and HBV, HIV, includes testing Lab prophylaxis. postexposure and labs include usu- is AZT HIV, of prophylaxis postexposure For exposure. post months 4 at once, test usually HCV and HBV year. a for up follow some patients will be treated with Hep ally B started within Ig. 72 hours of exposure and continued for at least 1 month. For HBV, from removed be must worker healthcare exposed the Since injuries. stick needle of component psychosocial a is there Additionally, the into investigation up follow and paperwork, out filling blood, drawing while else someone by replaced and contact patient direct of underreporting to lead may This wrong. something done have they that feel can worker healthcare exposed the records, patient’s Also, the injuries. exposed worker may feel in a state of anxiety and unrest while waiting for labwork to return to see if they have containers, sharps safer devices, safer in relies and multifactorial is injuries sharps Eliminating illness. threatening life a contracted safety process adoption. leadership focus, and Jenna Roach MD, Michelle Tarbox MD Tarbox MD, Michelle Jenna Roach R&CF ROACH, JENNA ROACH, R&CF Sharps Injuries Dermatology

ABSTRACTS 134 Eri Shoji, Ashley Maveddat, ReginaBaronia, Yasin Ibrahim Delirious ManiainBipolar1 Disorder andParkinson’s Disease R&CF SHOJI,ERI School: Texas Tech University HealthSciencesCenter employee moralecanbepositivelyimpactedbyimplemented strategiesfocusedonboostingmorale. staff morale and evaluated progress utilizing a quick 10-question survey to assess change in employee morale. Our findings indicate five strategies to boost low morale in a medical practice team. This quality improvement project implemented strategies to increase twenty- developed turnover.Hills and absenteeism, errors, productivity,cooperation, on impact negative a have can morale Low Leigha Sharp,M.D.,CloyceStetson,M.D. Improving EmployeeMorale: A QualityImprovement Project R&CF SHARP, LEIGHA School: Texas Tech UniversityHealthSciencesCenter about fireworksafetywithinfants. providers care home and practitioners both edcucating of importance the highlights reports with case This clinic injuries. burn their to the resolution in closely followed and discharged eventually was patient Each graft. skin autologous an with surgical intervention requiring additionally patient one with management, pain adequate provided and stabilized medically was patient Each admissions. BICU Center,day, requiring Medical same fireworks University the to same on secondary the to burns presented with months 12 of age the under children three report, case this In children. older with seen often more is it as literature the in mented undocu- largely is population young this in burns firework-related of significance The injuries. life-ending even or life-altering to superficial from ranging outcomes, diverse of myriad a in result can that finding rare fairly a are infants in burns Firework-related Shannon Seckel,DOandPattiPatterson,MD Fourth ofJulyfirework-related injuriesinthree infants requiring BICUadmissions: A case report R&CF SECKEL,SHANNON School: Texas Tech UniversityHealthSciencesCenter to anticholinergics, aswellsomeofrelevantsymptomatologyseen inthosewhodevelophypersensitivitiestoanticholinergics. allergic are who those for available treatments the dystonia, have who medications multiple with patients of management the on emphasis with decades 3 last the over articles pubmed relevant compiles managed. study be This should they how and histamines, anti to reactions hypersensitivity develop who those with associated risks the address properly that reviews few been have there this, Despite dystonia. of management the in available are options more and evolved, has dystonia of treatment the years, the Over is excluded,itsdefinedasidiopathicdystonia(Albaneseetal.,2013). the etiology of the dystonia. It’s classified as a sequela of some kind of nervous system pathology, heritable condition, and if allon else focuses axis second The lastly,features. it’sand associated onset, following duration static), or it’sprogressive not or whether - 135

ABSTRACTS eteral jets

School: Texas Tech University Health Sciences Center University Tech Texas School: Conclusions: Vitamin B riboflavin is an appropriate comparable oral agent to pyridium for producing urine staining and evaluating and staining urine producing for pyridium to agent oral comparable appropriate an is riboflavin B Vitamin Conclusions: the patency of ureteral jets at the Although time the of urine intraoperative stain cystoscopy. for riboflavin was not as statistically caus- for agent effective an be to proven has and safe a very is riboflavin that conclude can one pyridium, for stain the as significant ing urine staining. Results: The Results: Cochran-Mantel-Haenszel for ordinal outcomes was used to compute the appropriate Chi-square test for equivalence colored slightly for significance statistical reveal patients 85 of completion after Results groups. three the of intensity color between to bright colored urine stain for both pyridium and riboflavin. Methods: A 3 arm double-blinded, randomized controlled pilot study was performed. Group A 1 was administered thiamine as a pla- Methods: both were patients and surgeons The riboflavin. B vitamin administered was 3 group and pyridium, administered was 2 Group cebo, the to prior minutes) 15 (+/- hour 1 surgery of morning the on subjects the to administered were agents The treatment. the to blinded of color the grade to surgeons the by system grading a as intraoperatively used was scale color urine a with sheet data A procedure. the urine jet and to evaluate the strength of the urine jet. Objective: This study evaluates oral agents used to visualize ureteral jets at the time of intraoperative cystoscopy. Agents examined Agents cystoscopy. intraoperative of time the at jets ureteral visualize to used agents oral evaluates study This Objective: by the study are oral pyridium and vitamin B riboflavin. The study looks to determineof ifvitamin B administrationriboflavin is of a comparable oral a agent to standard pyridium for oral evaluating patency of dose ureteral jets at the time of intraoperative cystoscopy. Russell Stanley, D.O., Ann Erickstad, M.D., Cornelia deRiese, M.D. D.O., Russell Stanley, R&CF STANLEY, RUSSELL R&CF STANLEY, for urine staining to facilitate intraoperative observation of ur Pilot Study: Investigating oral agents School: Texas Tech University Health Sciences Center | Campus: Lubbock University Health Sciences Tech Texas School: Conclusions: Diagnosis was complicated by potential overlapping symptoms of PD psychosis, PD dementia, persistent delirium by precipitated been have may case complex This episode. manic 1 bipolar and CKD, by complicated toxicity lithium by triggered cognitive impairment secondary to PD leading to accidental overdose. Lithium and kidney functions were not monitored for a - de Hence, valproate. of levels suboptimal by exacerbated was It toxicity. lithium by triggered mania, delirious as presented This cade. drug levels and comorbid conditions. close monitoring of we urge Case History: A 69-year-old man with bipolar I disorder, PD, and Stage 3 CKD, was admitted for agitation and confusion, after adjustment of parkinsonian medications and mood stabilizers. Three months prior, worsening PD motor symptoms precluded his work and driving. One month he prior, was admitted for confusion and was discharged with a diagnosis of lithium toxicity due to CKD and accidental overdose. Lithium and amantadine was were initiated. discontinued. Valproate Post-discharge, he had visual and agitation, grandiosity, speech, pressured paranoia, status, mental altered with presented patient the up, follow On hallucinations. unit. was admitted to the inpatient psychiatry hypersexuality; and Background: Mania can present with elevated mood, agitation, hallucinations, and thought disturbances. Symptoms may overlap overlap may Symptoms disturbances. thought and hallucinations, agitation, mood, with elevated present can Mania Background: with psychosis secondary to neurodegenerative disorders Disease like (PD) Parkinson’s or metabolic conditions including lithium atro- brain as such factors organic with patients geriatric in delirium persistent cause to reported been has toxicity Lithium toxicity. (CKD). Kidney Disease PD, and Chronic Bipolar 1 Disorder, a manic patient with present We phy.

ABSTRACTS 136 School: Texas Tech University HealthSciencesCenter is bothsafeandeffectiveforpatients. method this using stones of treatment that study,shown our have In we stones. bladder of treatment for used been yet not has ogy technol lithotripsy pulse shock transurethral shows literature the technology.of lithotripsy Review pulse shock with combination stones of treatment fragment, to transurethrally can difficult pose a be challenge. Wecan stones present a bladder novel approach Because for treatment time. of bladder recovery calculi using short an Olympus a nephroscope in with basis outpatient an be on can done it as utilized commonly is approach transurethral The calculi. bladder treat to available techniques of variety a are There Amy Ruomei Wu, MD,RobertH.Grand, Thomas Nelius,MD,PranavSharma,and Werner DeRiese,MD. Novel approach usingshockpulselithotripsyforsurgical managementofbladdercalculi R&CF WU, AMYRUOMEI School: Texas Tech UniversityHealthSciencesCenter|Campus:Lubbock in casesofophiasis AA, particularlywhenconsideringitsfavorablesideeffectprofilerelativetoothertreatments. treatment promising a as considered be can triamcinolone Wescalp. with occipital microneedling left that his conclude on growth re- hair complete near noted we up, follow month prominent. 6 most At was loss hair his where scalp occipital left his on notably most improvement, gradual underwent He months. 6 of span the over Kenalog with microneedling of treatments four and solution 0.05% clobetasol with treated was who pattern, ophiasis areata, alopecia with male Caucasian 58-year-old a of case Wea present a to refers scalp. the of regions parietal Ophiasis and temporal, occipital, of the subtype of pattern loss hair AAband-like follicles. symmetric, a as presents that hair of destruction the in resulting disease autoimmune T-cellmediated a is (AA) areata Alopecia Usman Asad, BS;Daniel Wallis, MD;Michelle Tarbox, MD Ophiasis Alopecia Areata Treated With Microneedling: A NovelTherapy R&CF WALLIS, DANIEL - 137

ABSTRACTS - - The purpose of this study was to within-subject repeated measures ANO- within-subject repeated measures ANOVA. ANOVA. Twenty-six Twenty-six healthy university male subjects (18-35 years 2(VPAC strategy) x 2(direction) 2(VPAC SCHOOL OF HEALTH PROFESSIONS HEALTH OF SCHOOL variation) and These findings could help guide practitioners and coaches in selecting squat variations and incorporat strategy) x 2(squat informed consent, demographic/medical history questionnaires and an instructional video. Subjects practiced VPAC VPAC practiced Subjects video. instructional an and questionnaires history demographic/medical consent, informed Context: Olympic powerlifting is growing in popularity among recreational and competitive athletes. The barbell back squat (BackS) (BackS) squat back barbell The athletes. competitive and recreational among popularity in growing is powerlifting Olympic Context: is commonly prescribed, while the barbell back front squat (FrontS) is less commonly included. Alex Drusch, Joe McCormick, Troy Hooper, Brad Allen, Dennis G. O’Connell, Antonio Vintimilla, Phil Sizer Vintimilla, Antonio Allen, Dennis G. O’Connell, Brad Hooper, Troy Alex Drusch, Joe McCormick, SHP DRUSCH, ALEX SHP DRUSCH, The Effect ofVolitional a Preemptive Abdominal Contraction on Biomechanical Measures During a Front versus BackBarbell Squat Loaded measure the effect on of trunk volitional muscle preemptive activity abdominal and contraction lower (VPAC) quarter kinematics, kinetics and neuromuscular control of both squat variations. Methods: completed old) and received feedback. Surface electromyography (sEMG) electrodes and kinematic markers were applied. isometric contractions squat established one-rep-max reference A (1RM) sEMG was values. predicted. Maximal Subjects performed BackS voluntary trials at 75% 1RM while FrontS trials were performed at 75% BackS weight, both with and without Subjects VPAC. performed three repetitions of each condition with feet positioned on two adjacent force plates. Significant interactions and main effects were tested using a 2(VPAC School: School of Health Professions MATERIALS AND METHODS: Tissue stiffness values of the patellar tendon (PT), vastus medialis oblique (VMO) and superficial and (VMO) oblique medialis vastus (PT), tendon patellar the of values stiffness Tissue METHODS: AND MATERIALS medial collateral ligament (sMCL) were measured in 10 cadavers (5 unembalmed and 5 embalmed) using SWE at five and 20° of knee flexion. Intrarater reliability was analyzed using the intraclass correlation coefficient (ICC (3, 3)). The SWE data of the em- using a two-way mixed knee flexion angles were analyzed balmed conditions and tis- cadaver embalmed in values stiffness greater found and stiffness tissue cadaveric measured reliably SWE The CONCLUSION: behavior, on tissue Based flexion. knee of 20° and five between change to appear not does stiffness Tissue VMO. and PT the for sues embalmed cadavers are recommended for educational study and unembalmed cadavers are recommended for research and clinical simulation. School: School of Health Professions INTRODUCTION: INTRODUCTION: Cadavers are valuable resources for education, research, and clinical simulation, however, there is no quanti tative data to compare cadaver tissue stiffness relative to the embalmingcondition. This research provides recommendations for elastography (SWE). in situ tissue stiffness using shearwave cadaver use based on quantitative unembalmed and embalmed (ICC sMCL and 0.976), = 3) (3, (ICC VMO 0.969), = 3) (3, (ICC PT the for found measures reliability intrarater Good RESULTS: (PT VMO PT and the for conditions embalming between different significantly were measurements stiffness Tissue 0.826). = 3) (3, p < 0.001; VMO p = 0.008), but data sMCL is inconclusive. There were no significant tissue stiffness differencesbetween five p=0.348). VMO p=0.598; sMCL p=0.473; and 20° of knee flexion (PT higher significantly was activity muscle Trunk Results: differences. significant of location the identified tests Post-Hoc Tukey’s VAs. increased during performance FrontS time VPAC for versus A both BackS condition. squat regardless variations, of VPAC which maintain to ability improved VPAC A knees. and spine lumbar the on potential force detrimental decreased with associated be may a neutral lumbar spine during both squat variations. This finding is associated with decreased detrimental forcelumbar spine. Conclusions: potential on the and/or training programs. strategies for core control during their treatments VPAC ing Cameron C. Bassett PT DPT1, Kerry K. Gilbert PT ScD1, Troy L. Hooper PT ATC PhD1, Roger James PhD FACSM1 PhD1, ATC L. Hooper PT Troy ScD1, PT DPT1, Kerry K. Gilbert PT Cameron C. Bassett Shearwave elastography measured differences between unembalmed and embalmed knee tissue stiffness. knee tissue stiffness. and embalmed between unembalmed differences elastography measured Shearwave SHP BASSETT, CAMERON SHP BASSETT,

ABSTRACTS 138 School: SchoolofHealthProfessions Keywords: Nasalance,Nasality perception,Dialect in additiontoproductionvariations oforal-nasalbalancecharacteristics,perceptualvariations ofnasalityexistatadialectallevel. that, indicate findings These speakers/listeners. Mid-Atlantic than stimuli auditory synthesized the on ratings nasality higher and Mean tained. The results revealed that Texas South speakers/listeners showed significant higher nasalance scores on the reading passages 2015). al., et (Awan variation ob- nasalance were nasalization of degrees varying normal with stimuli vowel synthesized of on ratings DME and stimuli ends speech various of nasalance opposite at lie regions these of dialects two the since dialects, regions, Texasdistinct geographically two Mid-Atlantic from and obtained South were participants The (DME-M). modulus with oral-nasal balance characteristics estimated by nasalance, as wellnasality perception measured by direct magnitude estimation their on speakers’/listeners’ background of dialectal effects the investigated study This limited. is perception nasality in variation Previous studies have been examined the dialectal influence on speakers’ nasalance scores, however, information on cross-dialectal Youkyung Bae,Sue Ann Lee,Karl Velik, Yilan Liu,CailynnBeck,andRobert Allen Fox Differences innasalanceandnasalityperception between Texas SouthandMid-Atlanticdialects SHP LIU, YILAN School: SchoolofHealthProfessions contributed todeterminingiftelepracticeisaneffectiveservicedeliverymodelforchildrenwithcleftpalate. palate. Additionally, it cleft with children in errors production speech a treating for whether effective is determining approach intervention to phonological contributed study This telepractice. via children both in increase significant a exhibiting thus session, maintenance post-treatment a during accuracy 100% with produced were clusters consonant /s/ three that found study present The move picturesusingthemanipulationtools. Therapy sessionsprimarilyemployedaminimalpairsapproach or circles and lines draw to allowed were children the and interactive, was program function. The screen shared the using pictures video conferencing platform. Microsoft PowerPoint software was used to present pictures of target stimuli. The children viewed the WebExCisco the using telepractice via weeks 10 for sessions 30-minute during week a twice conducted was intervention Speech target soundsofeachchild,the/r/phonemewasalsotreated. Based on evaluations, three s-stop consonant clusters (i.e., sp, st, sk) were selected for both children in this study. In addition to the Edition. Testof Articulation-Third Fristoe Goldman the using evaluated was study current the in children the of articulation The the existenceofdevelopmentalerrors. the nearest speech clinic, and they required therapy and maintenance after repair surgery due to compensatory misarticulations and from away hours 1.5 about area, rural a in lived they because study particular this in participants the for method delivery service important Telepracticeavailable. an currently was is study one Only palate. cleft with children treating for adopted fully been not has telepractice however, US., the in model delivery service telepractice the of effectiveness the on evidence increasing is There accuracy byeliminatingtheirlearnedbehaviors. they cannot change their learned articulatory behavior. Thus, speech therapy is necessary for these children to improve their speech their speech after surgical procedures are done. However, approximately 30% of children still demonstrate misarticulation because improve may palate cleft with Children States. United the in children these treat to approach phonological a using over available However,palate. is cleft evidence with limited children in errors production speech treating to approach) phonological and proach ap- (articulation approaches major two are There TTUHSC. adopted at surgery repair palate two cleft undergone had in who China from telepractice siblings via intervention speech for approach phonological a using of effectiveness the evaluated study This Jennifer GilesandSue Ann S.Lee A Phonological Approach toTreat ConsonantClustersinChildren withRepaired CleftPalateviaTelepractice SHP GILES, JENNIFER

139

ABSTRACTS - - . School: School of Health Professions ver (ADIM), or no while VPAC performing test the Y-balance (YBT). Design: Within-subjects, repeated measure cohort design; 30 of sample Convenience community.Participants: local the from recruited laboratorysetting.Subjects Clinical 2015-2017.Setting: healthy individuals, ranging 20-41 years (x= 27.2 yrs).Intervention: Surface electromyography data was recordedon L5 subjects’ superficial multifidus (Mf)and obliqueswhile performingthe YBT in the anterior (ANT), posteromedial (PM), and showed there was posterolateral a significant mainANOVAs effect for One-way (PL) directions, ADIM,or ANOVAs using no-VPAC.Results: eitherABM, measures repeated 3(VPAC) x side) 2(Mf The (p<.05). directions YBT all in activation EO and IO both for strategy VPAC favoringstance directions, .003) = (p PL and .002) = (p PM the in strategy VPAC and side Mf between interaction significant a found side Mf.Pearson r correlation analyses revealed no Mf activation and YBT reach distancerelationship. Conclusion: In addition to PL and PM the in activation Mf superficial improved produce usedVPACto subjects healthy co-activation, abdominal an producing YBT directions, mostsignificant on thestance side. No relationship was found between trunk activation YBT reach and distances. These findings will help rehabilitation professionals understand the role abdominals and multifidi play during unipodal functional reaching activities. Context: Low back pain has a profound effect on daily activities ofTo Americans. many facilitate the rehabilitation process, im- provements in muscle activation patterns during functional activitiesis warranted.Objective: The determinethe effect of volitional unipo- (LE) extremity a lower activationduring multifidus superficial and abdominal on (VPAC) contraction abdominal preemptive dal functional task inhealthy subjects. Subjects either used an abdominal bracing maneuver (ABM), abdominal drawing in maneu Natesan K, Drusch A, Garcia L, Kunkel B, Hooper T, Kublawi M, Brismee J, Yang H, Sizer P. Yang Kublawi M, Brismee J, T, Garcia L, Kunkel B, Hooper A, Natesan K, Drusch Effect of VPAC on Muscles, in Healthy Humans. Effect of VPAC SHP NATESAN, KARTHICK SHP NATESAN, This research summarizes phase I of a two phase process. In phase I, our goal is to determine an appropriate neural based auditory position sitting the in testing included condition first The setting. fMRI an in utilized be can that protocol (APD) disorder processing position with stimuli presented condition included testing in a lying The second testing via audiometer. with stimuli presentation via Participants computer. were neuro-typical adults between the ages 18-30. Differences in testing performance between the two conditions were evaluated and compared to age appropriate norms to determine if results were negatively impacted by the condi- tions. Future studies: Phase II will include fMRI technology with a similar stimulus presentation. This new technology will allow and focus on areas of difficulty rehabilitation to become individualized nation, difficulty understanding rapid speakers and foreign accents, poor memory, difficulty following directions, difficulty with conversa- phone understanding difficulty abilities, music poor requests, repetition presentation, emotional and language expressive can disabilities and abilities auditory a person’s Assessing noise. in speech target to attending difficulty and localization, poor tions, explain the difficulties understandingpatient’s speech with an absence of hearing Auditory loss. processing evaluations can aid in the auditory system through the brainstem. further evaluation of School: School of Health Professions In the field of audiology, patients can exhibit symptoms of hearing loss; however, their hearing can still be within normal limits. Au- limits. normal within be still can hearing their however, loss; hearing of symptoms exhibit can patients audiology, of field the In ditory processing disorders (APD) may difficultiesfurther understandingexplain speechpatient’s with anabsence of hearing loss. Common symptoms include: academic difficulties in reading/spelling areas, deficits in integration of auditory-visual information, poor articulation of /l/ and /r/ sounds, difficulty understanding others, prosody/intonation confusion, poor attention, poor discrimi Brandi Murphy, Candace Hicks, LeighAnn Reel, and Tori Gustafson Tori Reel, and Hicks, LeighAnn Candace Brandi Murphy, SHP MURPHY, BRANDI MURPHY, SHP Analysis in fMRI Future A to Blast Exposure: in Relation Disorder Auditory Processing

ABSTRACTS 140 School: SchoolofHealthProfessions tions forparentsofyoungchildrenaswellaneedadditional researchinthearea. recommenda professional clinical implications regarding to point Results communicative intents. regarding qualitative discussion a and (TTR), ratio type-token (MLU), utterance of length mean using measured was language of complexity semantic and length utterance resulting the of analysis toy). An toy,tablet-based physical (i.e., separately variables two the with interacted dyad each as trials alternating during language of samples collect to utilized toys. was tablet-based Adesign and repeated-measures physical of 6 dyads consisting of a typically developing child (between 3;0 and 4;11) and one primary caregiver were recorded playing with This study examined how mobile screen devices impact the language of preschool children and adult caregivers during play. A total Emma Sanders,B.S., Tobias Kroll,Ph.D.,CCC-SLP Comparing Caregiver-Child Dyad LanguageProductions DuringTraditional Toy and Tablet-based PlayInteractions SHP SANDERS, EMMA School: SchoolofHealthProfessions with depressivesymptoms. accompanied disorders sound speech with individuals in intelligibility maximizing for plan therapy speech aid to potential the for implications have Findings mean. f0 and kHz 1-3 in energy in enhancement CS significant show not did HD with talkers talkers, HD symptoms showed NAS alteration in all acoustic measures and CS modification in speech rate and f0 range, but different to LD enhancement. NAS and CS Talkersusing by enhancement production speech need who populations clinical for plans vention with inter and protocols assessment valid establish to resource a provide and CS, and NAS of acoustics different on based processing language spoken affect diagnosed) (non-clinically symptoms depressive elevated how understand to aims project This symptoms. depressive with accompanied disorders sound speech with talkers in intelligibility maximizing for plan therapy speech aiding of potential a have and symptoms depressive with individuals in deficits communicative of nature the of understanding better a vide pro- will findings The symptoms. depressive elevated with individuals in modification CS and NAS of acoustics examine further symptoms benefited less from the CS modification compared to talkers with low depressive (LD) symptoms. The current study will CS). speech, (clear comprehension reduced with listener a A(HD) depressive high with people that revealed has research previous lenging communication environments due to the presence of background noise (noise adapted speech, NAS) or a situation to talk to chal in especially listeners, for perception speech facilitate to production speech their enhance reliably and spontaneously talkers theory,hyper-articulation(H&H) and hypo- the on Based symptoms. depressive Parkinson’sexperience and also stroke disease to It is widely acknowledged that individuals with depression have deficits in communication. A majority of people with dysarthria due Ashly Pingsterhaus,B.S.&Hoyoung Yi, Ph.D.CCC-SLP Acoustics ofNoise-Adapted&ClearSpeechinIndividualswithElevatedDepressive Symptoms SHP PINGSTERHAUS, ASHLY - - - 141

ABSTRACTS - School: School of Health Professions gate the effect of volitional preemptive abdominal contraction (AB) versus stabilization belt (StB) useon lower quarter- neuromus cular control during a loaded barbell squat (LBS). METHODS: healthy Twenty-eight males (19-29 years) were recruited from a test- during obtained were variables (sEMG) electromyography surface and biomechanical extremity Lower population. university 75% ing. one-rep-max Subjects’ (1RM) was calculated using 3-to-5RM LBS. Subjects performed 3 LBS repetitions at 75% 1RM under 4 conditions: no bracing/belt (NoSS), AB, bracing StB, and combined bracing and belt (AB+StB). Subjects performed the NoSS condition followed by the acceleration remaining The and conditions sEMG, time in velocity, variables random were order. assessed via a 2(phase) x while 4(stabilization peak strategy) ANOVA, angle data was assessed using a 1(side) x 4 (stabilization Post-Hoc strategy) Tukey’s tests and identified2(side) main Abdominal x effects. 4(stabilization RESULTS: ANOVA’s. strategy) were differences significant other no while (P<0.001) conditions AB+StB and AB during greater significantly was activity muscle found between conditions. Lumbar extensor and quadricep sEMG was significantly higher during the up versus down lift phases (P<0.01). The lumbar peak angle was significantly lower while the the hip during peakangle greater was significantlysignificantly greater andwas achieved faster time LBS Total (P<0.01). conditions AB and NoSS versus conditions AB+StB and StB during versus AB compare to study first the was This CONCLUSIONS: (P<0.001). conditions StB and NoSS to compared condition AB will inform coaches and athletes about safer and efficient LBS programming. These results StB use during a LBS. Core stabilization has been associated with Abdominal improved bracing athletic and performance and a decreased risk for injury. stabilization belts are incorporated but to these increase trunk strategies have stability, investi not been compared. To PURPOSE: Lynch D, Vintimilla A, Drusch A, Hooper T, James CR, Brooks T, Sizer P T, James CR, Brooks T, A, Hooper A, Drusch Vintimilla D, Lynch SHP VINTIMILLA, ANTONIO and Stabilization Belt Use During a Loaded Squat Abdominal Contraction Preemptive Biomechanical Responses to Volitional School: School of Health Professions Context: Daily distractions can affect the muscle performanceduring a functional task. Rehabilitation professionals should dem- onstrate a better understanding of cognitive distraction on trunk and lower extremity (LE) muscle activation patterns. Objective: preemptive a volitional maintain to ability the on has effect”) “Stroop (ECD distraction cognitive executive effect the determine To in healthy subjects abdominal while contraction performing (VPAC) a unipodal functional task. Subjects used an abdominal - brac Within-subjects, Design: (YBT). Test Y-Balance the performing while ECD, without and with No-VPAC, or (ABM), maneuver ing repeated measure cohort design. Setting: Clinical laboratory setting. Subjects recruited from local Participants: community. - Con venience sample of 30 healthy anterior individuals, the in ranging YBT 20-41 the performing years while (EO) (x= obliques 27.2 external and yrs). (IO) obliques Intervention: internal stance Surface and moving electromyography data subjects’ on was recorded The auditory Stroop consisted of program and feminine masculine (ANT), posteromedial (PM), and (PL) posterolateral directions. terms, requiring subjects to respond by moving the appropriate 5th Results: revealedfinger. The a x 2 2 (VPAC) ANOVA (ECD) main effect for strategy VPAC for ECD in all YTB direction (p<.05). moving and IO stance for effect main a revelaed Repeated revealed measures a ANOVA mainANOVA measures effectrepeated the addition, In (p=.006). distance reach PM to for Stroop that normal Conclusion: Our study revealed (p<.05). direction ANT as well as for moving EO in in the PM direction, VPAC EO subjects were able to perform a during VPAC a LE reaching task, even when cognitively distracted. affected YBT by Stroopreach distraction indistances the PMwere YBT direction. This study served to inform health professions on the effect ECD has on or daily living activity. strategies during LE reach task, such as during a recreational VPAC Stevens K, Garcia L, Kunkel B, Hooper T, Drusch A, Kublawi M, Brismee J, Sargent E, Wilhelm M, Yang H, Gan J, Sizer P. Yang M, Wilhelm E, Brismee J, Sargent A, Kublawi M, Drusch T, B, Hooper Garcia L, Kunkel Stevens K, SHP STEVEN, KHALID STEVEN, SHP The Effectof Executive Cognitive Distraction on SustainingVolitional a Preemptive Abdominal Contraction During a Unipodal Subjects. Movement in Healthy Functional

ABSTRACTS 142 School: Texas Tech University H2O2 throughapotentialunique mechanism. biofilms; GV isolates arenotresistant toLactobacillus-levels oflactic acid orH2O2;andcertain strainsofGV resisthighlevels of develop efficiently isolates GV isolates; clinical GV among conserved are genes virulence many gene, uptake siderophore the of gene, 91% carried the vaginolysin gene, and 18% carried the siderophore uptake gene. Our results suggested that: with the exception uptake genes by specific primers and PCR. Results showed that 82% of the isolates carried the sialidase gene, 73% carried the BFAP isolates (BFAP), protein associated seven siderophore biofilm vaginolysin, sialidase, of: presence concentration, the for isolates Finally,the survived. mM tested we 0.78 at and survived isolates eight concentrations, mM 0.39 and mM 0.195 At logs. 6 to 4 by lactic acid treatment reduced the growth of 14 the of the isolates. that WeAt 0.049 found mM concentrations. concentration, H2O2 reduced the growth these of the isolates to isolates GV the of resistance the measured we Thus, acid. L-lactic mg/mL 7 and acid mg/mL 72 produce D-lactic Lactobacilli OD600. 0.98 to 0.15 from varied that masses biofilms produced isolates the that revealed this study we analyzed 17 GV isolates for the described possibilities. Biofilm analysis of the isolates,In throughgenes. crystal violetvirulence-associated staining, of presence/absence the or (H2O2), peroxide hydrogen and acid lactic lactobacilli-produced the to This population shift may be due to the ability of GV to compete with lactobacilli through: efficient biofilm development, tolerance (GV). vaginalis Gardnerella being prominent most the bacteria, anaerobic facultative by replaced are BV,lactobacilli During the lactobacilli. by predominated is vagina healthy, the When disease. inflammatory pelvic and miscarriages, birth, pre-term for risk increased an with associated is It age. reproductive of women in infection vaginal common most the is (BV) vaginosis Bacterial Betsaida Delgado,LondonMena,Gary Ventolini, JaneColmer-Hamood, and Abdul Hamood Isolation andCharacterizationofGardnerella vaginalisClinicalIsolates UNDG DELGADO, BETSAIDA School: Texas Tech University therapeutic approachesformetastaticPCapatients. and methods treatment improved of development the to contribute and PCa of understanding the advance will research our hope Weinterest. of genes these of promoters the to PEDF of binding the validate to immunoprecipitation chromatin use will we step, mRNAPI3-Kinase, the of subunit catalytic the of expression targetnovel identifying PDK1, PEDF.and for AKT1 genes next a As the inhibits significantly WePEDF analysis. that PCR Real-Timedemonstrated quantitative through pathway PI3-Kinase/AKt the of effectors mRNA of expression the measured we hypothesis, this factor.Totest transcription a as functioning is PEDF nuclear that hypothesize we cells, these In cells. PCa in PEDF nuclear of function the characterize to thus is project this of aim The cells. described as reduced in PCa when compared to normal cells, we surprisingly observed PEDF expression within the nucleus of PCa cent findings from our laboratories demonstrated that PEDF is a therapeutic target for PCa. While PEDF secretion has been widely body.Re- the throughout functions neurotrophic and anti-tumorigenic, anti-angiogenic, displays that secreted family and Serpin the expressed in protein naturally a is (PEDF) Factor Epithelium-Derived Pigment The PCa. in need unmet urgent an represents thus efficacy lethality,increased therapy.of with multimodal alternatives intensive therapeutic after new even of development The onset rapid with largelyincurable, remains PCa metastatic (PCa), cancer prostate localized of growth controlled clinically Despite Reagan Ball,Dr. StephanieFilleur, Dr. SouadSennoune The FunctionofNuclearPEDFinProstate CancerCells UNDG BALL, REAGAN UNDERGRADUATE 143

ABSTRACTS - - School: Texas Tech University Tech Texas School: harmonic series with a number of datapoints from the Google Ngrams, Historical American English, and Brown corpora are able to able are corpora Brown and English, American Historical Ngrams, Google the from datapoints of number a with series harmonic model and understand better to us allow can lexicon the of size the Estimating 1961. in lexicon English the of size true the estimate the rate of change of all languages. In Assistant, the future, Alexa, natural Google language processing Amazon systems (e.g. Siri, automatic hospital translators) may be burdened with decades of outdated words, phrases, and dialects. func- However, applying to order in these databases their adjust to systems voice-based these allows size lexicon approximate accurately to formulas derived tion accurately in our rapid paced world. Zipf’s Law approximates the relative frequency of a word given its statistical rank in terms of the frequency of the most used word used most the of frequency the of terms in rank statistical its given word a of frequency relative the approximates Law Zipf’s in the lexicon at a particular point in Applying time. Zipf’s Law to each word in the lexicon yields an approximating sequence of estimated be theoretically can language a in words of number the fit, perfect Assuming language. a in word every for frequency the hyper Zipf-Mandelbrot the of summation piecewise a that demonstrate I Here, series. harmonic Zipf the of sum partial nth the with William Kariampuzha William UNDG KARIAMPUZHA, WILLIAM Alternatives law and its Estimating Lexicon Size Based upon Zipf’s School: Texas Tech University Tech Texas School: These findings indicate that the (1) fission-mediated fragmentation of mitochondria, along with the (2) production of harmful su- without. to compared as thioredoxin with treated HECECs in lowered is cells, endothelial endocardial of death (3) the and peroxide of human thioredoxin against cardiac damage in diabetic patients. This points to possible protective effects We found that mitochondria were shorter and We fragmented in cells when cells not exposed to treated however, with hyperglycemia; rates apoptotic less in resulted also cells treated Thioredoxin thioredoxin. with those to compared fragmented more were thioredoxin and less superoxide formation in HECECs. The thioredoxin class of proteins, however, has been found to play a role in protecting against harmful ROS such as superoxide. In superoxide. as such ROS harmful against protecting in role a play to found been has however, proteins, of class thioredoxin The This fission. mitochondrial DRP1-faciliated induced glucose against protecting in thioredoxin of role the investigated we study, this mM (25 conditions hyperglycemic to exposed were (HECECs) cells endothelial endocardial human – four-pronged was experiment under breakage mitochondrial visible of form the in mitofission measured (1) We without. vs. thioredoxin with treated and glucose) us- produced superoxide of amount the measured (3) cytometry, flow through cells among rates apoptosis measured (2) microscope, through mitofission mediates that protein a DRP1-protein, the of activation measured (4) and resonance, paramagnetic electron ing blotting. Western mia affects cardiac endothelial cells and their mitochondrial metabolism is not clear. Within mammalian hearts, endothelial cells are cells endothelial hearts, mammalian Within clear. not is metabolism mitochondrial their and cells endothelial cardiac affects mia focus the are they As such, cardiomyocytes. to prior apoptosis undergo and number, by 64% to up numerous, constituting most the of our study. Cardiovascular Cardiovascular complications are highly prevalent in diabetic patients. Hyperglycemia has been linked to mitochondrial dysfunc- with the tion formation and of cell harmful injury, reactive oxygen species (ROS), such how as hyperglyce superoxide. However, Andrew Ibrahim UNDG IBRAHIM, ANDREW IBRAHIM, UNDG Thioredoxin as a for Treatment Diabetic Patients: The Protective Effects ofAgainst Thioredoxin Cardiac Endothelial Cell Death Hyperglycemia Damage under and Mitochondrial

ABSTRACTS 144 School: Texas Tech University to detectbacteriaencasedwithinabiofilm,whichfurther validates theMolecuLighti:Xdeviceforpatientuse. the extracellular matrix of the biofilm still exhibit detectable autofluorescence. These data demonstrate that the device has within the encased ability bacteria that demonstrate to able were and model, murine wound chronic established an utilizing biofilm bacterial real time. In this study, we assessed the ability of the MolecuLight i:Xdevice in to wound detect autofluorescentproperties a of in a bioburden polymicrobial bacterial relative of detection allowing bacteria, of species clinically-relevant most of properties rescent customized care. Bacterial fluorescence imaging with the handheld MolecuLighti:X device uses safe violet light to detect autofluo- provide better to diagnosis accurate is wound sophisticated a with patient a for process healing the to step essential An ronment. envi- wound chronic the of characteristics complex the on information little provide often but identification, microbial for of testing periods long require methods diagnostics Current to treat. and to characterize difficult are that infections generating biofilms, Chronic wounds are a significant cause of patient morbidity and mortality in the US annually, and commonly harbor polymicrobial Department ofHonorsStudies, Texas Tech University1;MolecuLightInc.2 and Allie ClintonSmith1 Monique Jones2, Y.M. Diaz1, WilliamLaura C. Little1, George1,Rachel Isaiah Reynolds1, Landrye Rennie2, Lopez1, J. Andrea In vivodetectionofpolymicrobial bacterialbiofilmwith real-time fluorescence imaging UNDG LOPEZ, ANDREA School: Texas Tech University Affiliate Inc.grant14GRNT18750014,and a TTUHSCPreliminaryDataGrant. TexasHeart Association NMR, American Bruker MHz 500 a for NSF AwardCHE-1429195 by part in supported was work This use andotherapplications. AGs are not bactericidal and are not toxic to mammalian cells, making them better than traditional AGs as HC inhibitors for clinical kanamycin compound, traditional parent Unlike the amphiphilic A. to these compared AGs, when HCs Cx26 vs. Cx43 on potency HCs. Using a newly developed cell-based bacterial growth complementation assay we found several leads with superior inhibitory synthesized and tested several amphiphilic AGs derived from kanamycin that do we not have antibiotic Here, effect, but still inhibitors. inhibit connexin HC connexin as identified recently been have (AGs) aminoglycosides Antibiotic potential. great pharmacological have HCs connexin of inhibitors selective Therefore, deafness. with associated been have HCs (Cx26) 26 connexin active stroke, deafness, skin diseases, and cataracts. Connexin 43 (Cx43) HCs play a role in cardiac infract and stroke, whereas abnormally mal opening of “free” undocked HCs can produce cell damage and participate in the mechanism of disorders such as cardiac infarct, communication. cell-to-cell mediate that channels gap-junctional Abnor form cells adjacent from (HCs) hemichannels Connexins ermo A. Altenberg N. Madher AlFindee, YagyaFiori, C. Mariana P.Cheng-Wei, Krishnan, Kjellgren Srinivasan Guill- T.Abbey Subedi, and Chang Selective inhibitionofdifferent isoformsofconnexinhemichannelsbynewamphiphilicaminoglycosides UNDG KJELLGREN, ABBEY - 145

ABSTRACTS - - - School: Texas Tech University University Tech Texas School: tion, and antibiotic susceptibility. SA-SCVs are induced under stressful microbial environmental conditions, such as coinfection with Pseudomonas aeruginosa, common in chronic wound specimens. Differences in SA-SCV morphology and biochemical reac- failure. treatment and healing wound delayed to contribute can which detection, SA-SCV in errors for responsible are SA from tions In a clinical setting, SA-SCVs present difficulties such asscreening and obtaining by specimens decreasedwound chronic in SA-SCVs of consequence and prevalence the evaluate antibioticto sought we study, susceptibility and reoccurring infections. Inthis samples for the presence All of suspected SA-SCVs. SA-SCVs were assessed for their biochemical reaction and identification via SA-SCVs, of burden unrecognized previously a harbor specimens wound chronic that suggest results Our testing. diagnostic routine which has implications for diagnostic and patient care. Staphylococcus aureus Small Colony Variants (SA-SCV) are a novel colony phenotype of Staphylococcus aureus. SA-SCVs differ SA-SCVs aureus. Staphylococcus of phenotype colony novel a are (SA-SCV) Variants Colony Small aureus Staphylococcus pigmenta hemolysis, rate, growth decreased and colonies of smaller formation the (SA) by aureus Staphylococcus wild-type from Department of Honor Studies, Texas Tech University^1; Southwest Regional Wound Care Center^2 Wound University^1; Southwest Regional Tech Texas Department of Honor Studies, Landrye Reynolds^1 and Isaiah George^1, Klara C. Keim^1, Nicholas Sanford^2, Allie Clinton Smith^1 Sanford^2, Klara C. Keim^1, Nicholas Landrye Reynolds^1 and Isaiah George^1, UNDG REYNOLDS, LANDRYE UNDG REYNOLDS, Wounds in Chronic Colony Variants Small Detection of Staphylococcus aureus School: Texas Tech University Tech Texas School: tion to cancer, potassium channels can become dysregulated, allowing an increased efflux of positivelyout of chargedthe cell, potassium overriding many checkpoints ions within the cell cycle, and permitting the cell the ability to divide uncontrollably as a result. It has also been found that overexpression of potassium channels also promotes cell mobility of cancer cells, often leading thera finding of study the in used be would that channel potassium archetypal the is K+channel) prokaryotic (a KcsA metastasis. to peutic drugs that could act as a “gatekeeper” (in the case of an inhibitor) to regulate the flow of water molecules as a consequence of positively charged ions (K+-ions) moving out attempt of to the do cell. We this by employing a liposome fluorescenceassay in K+ the inhibit) (or “block” therefore can inhibitor an of presence The activity. channel indicates decay signal fluorescent the which Finally, blocker. novel therapeutic putative a identifying potentially and signal, fluorescent the in decay the halting activity, channel of properties blocking the as well as membrane, cell the across K+-ions of movement the track to utilized be will electrophysiology reliable and robust a provide will assay functional high-throughput novel this of development The drugs. therapeutic new putative ion channels blockers in general. first drug screening approach to identify Voltage-gated sodium and potassium Voltage-gated channel dysregulation and overexpression have been found to be the leading cause of many channel-related diseases, Alzheimer’s disease, including schizophrenia, epilepsy, and most several recently, cancer types. In rela Cuello, Luis and Ostermaier, Emily and Ostermaier, Cuello, Luis UNDG OSTERMAIER, EMILY OSTERMAIER, UNDG use therapeutic potential with libraries drug of screening the for Assay Fluorescence Liposomes High-throughput a of Optimization diseases dysfunction related for ion channel

ABSTRACTS 146 School: Texas Tech University cursors andcanbeviewedas basistostudytheinvivogene-environment(EAAC1-VP pre- neuronal undifferentiated the in maintenance redox in EAAC1 for role critical a indicate results biochemical Our Conclusion: and GSH reduction were further enhanced upon EAAC1 silencing in neuroblasts. VPA experiments in EAAC1 mice are underway. tantly, EAAC1 protein levels along with GSH levels were significantly (p<0.05) reduced at 400µM VPA. The VPA-elicited ROS Concomi 400µM. at (p<0.05) 61% by increased significantly were fluorimetry by measured levels ROS 400µM. at (15%) tion Results: MTT results demonstrated that VPA significantly decreased the viability of neuroblasts (P<0.05) with a maximal inhibi lized. VPA wasusedatconcentrationsof25,50,100,200,400µMfor24hintheneuroblasts. uti- were mice knockout EAAC1 and cortex brain day-18 embryonic from neuroblasts rat immortalized Spontaneously Methods: phenotype. to ASD-related relevance EAAC1-VPAits investigated and we interaction study drug this in to Thus, ASD. level molecular and behavioral the at disorder,obsessive-compulsive schizophrenia, to linked is mutation disability,intellectual characteristics many shares which of all Importantly,EAAC1 GSH. for precursor the supplies it as transporter (EAAC1)-cysteine 3” “Excitatory TransporterAmino requires Acid brain growing the in viability neuroblasts regulating for essential antioxidant an (GSH), Glutathione outcomes. clinical developing ASD. Redox abnormalities are strongly correlated to the interactions between different toxic exposures and ASD-related of risk the enhances disorders mood and (VPA),epilepsy valproate treat sodium to of used administration drug Prenatal a genesis. the determine pharmaceuticals and patho- pollutants ASD to exposure utero in as such influences (55%) environmental and (33%) Genetic births. 59 in one affects that disability neurodevelopmental complex a is (ASD) Disorders Background: Spectrum Autism ing, Univ. ofNebraska,Lincoln,NE-685883.;3Dept.Pathology, UT SouthwesternMedicalCenter, Dallas, TX-75390. Engineer Biomolecular and Chemical of Dept. Texas-79430.;Lubbock, 2 TTUHSC, Neuroscience, and Pharmacology of 1Dept. than3, George Henderson1,MadhusudhananNarasimhan1 Mahimaina Lenin Bergeson1, E. Susan Kidambi2, Srivatsan Panthagani1, Praneetha Kisby1, Wolpert1,Brent John Liu1, Xiaobo Interaction ofValproate andEAAC1/RedoxNetwork UNDG WOLPERT, JOHN School: Texas Tech University episodes ofPA outbreakinthehospital. to react and predict better to us allow may of knowledge ability This infection. the PA cause influence to greatly factors virulence certain that conclude we Overall, sepsis. causing and infection wound a establishing of capable more were activity protease high with isolates environmental model, wound chronic murine our In vivo. in comparison for environment, the and patients both from isolates. Having determined the proteaseproduction of all isolates invitro,weselected strains withthehighestandlowestactivity, isolates. The most dramatic result was the remarkably higher protease activity among patient isolates compared with environmental isolates patient for than for environmental isolates. Similarly, higher both total quorum was sensing and beta hemolysis of red blood cells biomass were elevated in patient biofilm that found we isolates, patient and environmental of virulence differential the of examination Through patients. BICU of tissues damaged and dead the through spread rapid the for necessary less is but patients MICU of tissues intact more the invading for beneficial is production pyocyanin increased that theorized we tissues, host damage produced higher levels of pyocyanin compared to isolates from the Burn ICU. Considering the documented ability of pyocyanin to ICU Medical the from isolated activity.strains protease that and revealed hemolysis, type production, ICU pyocyanin by Analysis which virulence factors promote pathogenesis. To study this phenomenon, we compared biofilm formation, quorum sensing activity, understudied. WePAisolated determine to isolates the of phenotypes the characterized and infections and sinks hospital both from been have (PA),patient aeruginosa to Pseudomonas environment as from such transitioning However,for thrive. requirements the Combatting nosocomial infections is a significant challenge facing modern medicine. In the Intensive Care Units (ICUs), pathogens, Rebecca Schneider, DerekFleming,Garrett Welch, HuiHua, Angel Cueva,LaurenChoate, andKendraRumbaugh Characterizing thePhenotypicTransition ofPseudomonasaeruginosafrom theHospital Environment toNosocomialInfections UNDG SCHNEIDER,REBECCA A drugexposure) interactionin ASD. - - - - 147

ABSTRACTS - School: Texas Tech University Tech Texas School: In recent years, there has been an increased interest in innovative teaching strategies and their effectiveness in the K-12 classroom. K-12 the in effectiveness their and strategies teaching innovative in interest increased an been has there years, recent In enrichment project-based novel implemented has organization, College Honors University Tech Texas a Corps, Leaf & STEM The activities in a group setting to instill a passion for education and cultivate an interest in STEM fields in students from the Lubbock Independent School District (LISD). Comprehensive feedback forms from students have yielded qualitative and quantitative data two from collected was Feedback needs. student individual meet that projects adaptive create to us enabled and informed have that via accumulated was data feedback Student school. high one and school middle one as well as students K-5 for centers after-school post-project feedback forms as well as a general mid-semester feedback form. Results reveal that group activities have positively engagement in learning. In impacted addition, the we students’ have seen students improve their communicative and collaborative skills along with an overall enhancement of the group-based learning activities that we have implemented. In the near future, we hope to expand our activities to the regional level in order to programs outreach make educational a effective greater how impact reexamining for on foundation the a wider as serve U.S. may education studies system, our from and insights we the that anticipate can be constructed, evaluated, and integrated into existing scaffolds. Charles Zhu, William Kariampuzha, Elizabeth Koch, Tingzeng Wang, Viren Vasadani, Nicolas Michael San Francisco Dzmitry Savitski, Radha Patel, Chad Cain, Fonseca-Escobar, Daniel Xue, UNDG ZHU, CHARLES UNDG ZHU, Learning Group-Based Around Centered Outreach to Improving Approach Adaptive An School: Texas Tech University Tech Texas School: Unpaid caregivers provided 18.5 billion hours of care to patients with age-related dementias in $321,780.^1 2018.^1 approximately Despite at crippling, this, is the housing lifetime and attention, medical care, skilled for dementia with diagnosed patient a to cost Our objective was to develop a way to provide supportive care for dementia patients without Weincreasing cre- financial burden. respite support, emotional including tasks caregiving dementia perform to students pre-health for home nursing a at platform a ated week each volunteers of number the recorded We entertainment. and feeding, symptoms, behavioral managing caregivers, paid for through an online database, documented custom project outcomes, and recorded time events. Pre-health spent students on received leadership “pay” for outside their of work volunteer premedi through the for benefits the documented improvements and patients to provided to care the of value the their calculated medical We setting). healthcare school a in hours applications (volunteer provided work volunteer of hours 480 with care, unpaid of hours ~1700 contributed group our years, four past the Over students. cal similar If alone. semester past the in $12,096 and year per ~$5,355 be to care this of value the estimated We months. four past the in work our of sustainability The year. per $51,988,608 be would care this of value the university, US every at established were groups was made possible by a mutually beneficial American relationship Geriatrics between Society pre-health students, members of the Student Interest Group, memory care staff, and dementia patients. Memory patients need supportive care, and pre-health students mobi- appropriately if that resource untapped currently a are students pre-health Therefore, care. supportive providing from benefit burden financial the increase not does which development, professional in for paid year per hours 4,126,080 contribute could lized, on either patients or the US economy. ^aGarrison ^aGarrison Institute on Aging, Texas Tech University Health Sciences Center, 3601 4th TX 79409 Street, Lubbock, 2500 Broadway, MS University, 9424, Tech Lubbock, United States; ^bTexas TX 79430, Willms J^a, Young K^a, Chavez A^b, Zon A^b, Patel R^b, Perez A^b, Wolpert J^b, Thomas G^b, Gassman T^b, Culberson J^a T^b, Culberson Thomas G^b, Gassman J^b, Wolpert A^b, Patel R^b, Perez A^b, A^b, Zon K^a, Chavez Young J^a, Willms UNDG YOUNG, KOBE YOUNG, UNDG - of the Care Problem the Economic Address to Designed Program Volunteering/Mentorship Student of a Premedical Development Units Geriatric Memory Ratio in Skilled-Care giver-Patient 148 ABSTRACTS 149

ABSTRACTS

Title advisor) your work; to your (contributors Authors was performed the work where Institution Abstract/Introduction of the poster should contain figures, and may include a hypothesis, a methods/approach section, and a and may include a hypothesis, a methods/approach The Body of the poster should contain figures, discussion. Legends and Figure Figures Directions Conclusions and Future

• • • • • •

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INFORMATION 150 All posterpresentations, Tuesday -Thursday, willtakeplaceonthe1 POSTER PLACEMENT ANDREMOVAL: Attend theThursday Poster Exhibit Session 12:00–1:00PM For postercompetition participants: andafternoon) allThursday(morning Attend the Wednesday Poster Exhibit Session 12:00–1:00PM For all Wednesday postercompetitionparticipants: and afternoon) (morning Attend the Tuesday Poster Exhibit Session 12:00–1:00PM For all Tuesday postercompetitionparticipants: (afternoon) below: Please checkthetimeanddateofyour posterpresentation andattendyour respective Poster Exhibit Session time tolearnaboutexciting researchthis sessiontoencourageparticipants new andnetwork withotherstudentsandprofessors. pm. THIS EVENT ISREQUIRED BYALLPARTICIPANTS tobeconsidered forpostercompetitionprizes. We hold search withattendees.Thisevent willfollow the afternoonpostersessionson Wednesday andThursday from 12:00–1:00 Similar toaconference postersession,the‘Poster Exhibit’ asanopenpostersessionforstudentstodiscusstheirre- serves POSTER EXHIBITSESSION below). indiscussionsduringtheopenpresentationmaining membersofthegroup mayparticipate duringthe‘Poster Exhibit’ (see In thecaseofgroup presentations, onlyoneindividualmayverbally present theirpostertothejudges.However, there- Point deductionswillbeenforced ifthe12minute timeframeisexceeded. by thejudges. be nointerruptions Two (2)additionalminutesofquestionsfrom thejudgeswillfollow eachpresentation. ent your poster. Thetotalallottedtimeforeachposterpresentation willbeten(10)minutes. During thattime,there will If you are notinfront ofyour posteratthebeginning ofyour topres your designatedtimeyou opportunity willforfeit - POSTER: PRESENTING YOUR removed by thistimewillbedisqualified-noexceptions. their postersinplaceby 8:30AMThursday. Posters must be takendown by 5PMonThursday. Anyposternothungor Poster boards willbeavailable forpresenters tohangtheirposterson Wednesday evening at5pm.Allpresenters musthave Thursday session(1:00PM-4:00PM) March session(9:00AM–12:00PM)andafternoon 12,2020,morning or removed by thistimewillbedisqualified-noexceptions. their postersinplaceby 8:30AM Wednesday. Posters mustbetakendown by 5PMon Wednesday. Anyposternothung Poster boards willbeavailable forpresenters tohangtheirposterson Tuesday evening at5PM.Allpresenters musthave Wednesday March session(1:00PM-4:00PM) session(9:00AM-12:00PM)andafternoon 11,2020,morning removed by thistimewillbedisqualified-noexceptions. their postersinplaceby 8:30AM Tuesday. Posters mustbetakendown by 5PMon Tuesday. Anyposternothungor Poster boards willbeavailable forpresenters tohangtheirpostersonMonday evening at5PM.Allpresenters musthave Tuesday, March session(1:00PM-2:00PM) 10,2020,afternoon Please seebelow regarding forinstructions your specificpresentation timeslot: (ACB) lobby. st and2 nd floorofthe Academic Classroom Building 151

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