How to Uproot a Mandrake: Reciprocity of Knowledge Between Europe, the Middle East, and China Yuriko Yamanaka, Isabelle Draelants
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Nightshade”—A Hierarchical Classification Approach to T Identification of Hallucinogenic Solanaceae Spp
Talanta 204 (2019) 739–746 Contents lists available at ScienceDirect Talanta journal homepage: www.elsevier.com/locate/talanta Call it a “nightshade”—A hierarchical classification approach to T identification of hallucinogenic Solanaceae spp. using DART-HRMS-derived chemical signatures ∗ Samira Beyramysoltan, Nana-Hawwa Abdul-Rahman, Rabi A. Musah Department of Chemistry, State University of New York at Albany, 1400 Washington Ave, Albany, NY, 12222, USA ARTICLE INFO ABSTRACT Keywords: Plants that produce atropine and scopolamine fall under several genera within the nightshade family. Both Hierarchical classification atropine and scopolamine are used clinically, but they are also important in a forensics context because they are Psychoactive plants abused recreationally for their psychoactive properties. The accurate species attribution of these plants, which Seed species identifiction are related taxonomically, and which all contain the same characteristic biomarkers, is a challenging problem in Metabolome profiling both forensics and horticulture, as the plants are not only mind-altering, but are also important in landscaping as Direct analysis in real time-mass spectrometry ornamentals. Ambient ionization mass spectrometry in combination with a hierarchical classification workflow Chemometrics is shown to enable species identification of these plants. The hierarchical classification simplifies the classifi- cation problem to primarily consider the subset of models that account for the hierarchy taxonomy, instead of having it be based on discrimination between species using a single flat classification model. Accordingly, the seeds of 24 nightshade plant species spanning 5 genera (i.e. Atropa, Brugmansia, Datura, Hyocyamus and Mandragora), were analyzed by direct analysis in real time-high resolution mass spectrometry (DART-HRMS) with minimal sample preparation required. -
Introduction
Introduction Just over a century has passed since a team of scholars from across Europe, led by German historian of ancient philosophy and science Hermann Diels (1848–1922)1, compiled the manuscripts containing Greek medical texts and their medieval translations into a catalogue2. Following such classical bibliographies as the Bibliotheca Graeca by Johann Albert Fabricius (1668–1736)3 and the several Bibliothecae by Albrecht von Haller (1708–1777)4, Diels, as the catalogue became known, was a landmark in classical and medico-historical scholarship5. It was not completely 1 For a broad approach to Diels’ multifaceted activity, see for example Calder et al. 1999. All works referred to in this introduction are cited in an abbreviated form (author’s last name and year of publication). For the full reference, see the bibliography at pp. xxi–xxx. 2 The catalogue was published in two issues in 1905 and 1906, in the proceedings of Berlin Acade- my of Science, with a supplement in 1908 in the same series (Diels 1905, 1906a, and 1908, respectively). The 1905 and 1906 issues were published together as a volume in 1906 (Diels 1906b) with a slightly different title (Die Handschriften der antiken Ärzte, Griechische Abtei- lung) which implied that a similar programme would have dealt with the Latin manuscripts. The frontmatter of the second issue (1906a), which provided a general presentation of the programme, the list of the collaborators, and the bibliography, is reproduced as the front matter of this volume with the same pagination as in the first publication. All three issues (1905, 1906a, and 1908) were reprinted in 1970 with an introduction by Fridolf Kudlien (1928–2008) (Kudlien 1970). -
Resources of Ilmulamraz During Early Abbasid Caliph (7Th-9Th
Bangladesh Journal of Medical Science Vol. 20 No. 02 April’21 Review article: Resources of IlmulAmraz during early Abbasid caliph (7th-9th C.E) up to the work of Al-Razi Khan Nazia Zubair1, Shaikh Saleem Ahmad2, Wasim Ahmad3, Mohd Zulkifle4, Shahnawaz5 Abstract: Aim and Objective:The literature of Ilmul Amraz occupies a pedestal position in Unani medicine.The literature, however, is scattered among many manuscripts and requires being collected and compiled for better understanding and comprehension of disease concepts of Unani medicine. The material has been collected from the original resourcesof early Abbasid caliph (from7th-9thC.E) till the period of Al-Razi and briefly introduced in this article. Material and Methodology: The proposed literary research is conducted through ‘input-processing-output’ approach. The literature has been collected from different classical texts, reference books and various digitalized mode. Conclusion: The present review article underlines the contributions of Arab physicians, their original works, innovations, and practical experiences. The impact of theoretical contribution of Al Razi manifests in ancient Greco-Roman theory of diseases. Keywords: Ilmulamraz, literature, scattered, compilation, understanding Bangladesh Journal of Medical Science Vol. 20 No. 02 April’21. Page : 228-233 DOI: https://doi.org/10.3329/bjms.v20i2.51528 Introduction: Abbasid caliphate (750-1517C.E) was the guidance of Yuhanna-bin-Masawayh (d.857C.E) the golden age of Arab medicine in Arabic history. and later by his pupil Hunayn-Ibn-Ishaq (Johannitus) The literary enlightenment did not bog down with the (d.873A.D.).3. The other translators during the annihilation of Baghdad in 1258 C.E, but continued to translation movements were Lusuf al-khari-al-Qass, flourish in Damascus, Cairo and Cordoba (H.A Hajra Thabit- bin-Qurra (826-901AD) Qusta-bin Luqa (C. -
Ancient Greek Physicians
Ancient Greek physicians Abascantus Acesias Acron Acumenus Adamantius Aegimus Aelianus Meccius Aelius Promotus Aeschines (physician) Aeschrion of Pergamon Agapetus (physician) Agathinus Agnodice Alcmaeon of Croton Alexander of Tralles Alexander Philalethes Epipodius and Alexander Alexias Alexion Alexippus Amentes Ammonius Lithotomos Anaxilaus Andreas (physician) Androcydes (physician) Andromachus Andromachus (physician) Andron (physician) Andronicus (physician) Anicia Anonymus Londinensis Antaeus (physician) Antigenes Antigonus (physician) Antiochis Antiochus (physician) Antiochus Philometor Antipater (1st-century BC physician) Antipater (2nd-century physician) Antiphanes of Delos Antonius (herbalist) Antyllus Apollodorus (physician) Apollonides (physician) Apollonides of Cos Apollonios of Kition Apollonius (physician) Archigenes Aretaeus of Cappadocia Aristogenes (physician) Aristoxenus (physician) Asclepiades of Bithynia Asclepiades Pharmacion Aspasia the Physician Athenaeus of Attalia Athryilatus B Bacchius of Tanagra Bolus of Mendes C Calliphon of Croton Chrysippus of Cnidos Claudius Agathemerus Criton of Heraclea Ctesias D Damocrates Democedes Demosthenes Philalethes Dexippus of Cos Dieuches Diocles of Carystus Pedanius Dioscorides Diphilus (physician) Draco (physician) E Epicles Erasistratus Eudemus (physician) Eudoxus of Cnidus Euphorbus (physician) Euryphon Evenor G Galen Glaucias (physician, 3rd century BC) Glaucias (physician, 4th century BC) -
Genus Mandragora (Solanaceae)
Bull. not. Hist. Mus. Land. (Bot.) 28(1): 17^0 Issued 25 June 1998 A revision of the genus Mandragora (Solanaceae) STEFAN UNGRICHT* SANDRA KNAPP AND JOHN R. PRESS Department of Botany, Tne~Natural History Museum, Cromwell Road, London SW7 5BD * Present address: Waldmatt 6, CH-5242 Birr, Switzerland CONTENTS Introduction 17 Mythological and medicinal history 18 Taxonomic history 18 Materials and methods 19 Material examined 19 Taxonomic concepts 20 Morphometrics 21 Cladistics 22 Results and discussion 22 Species delimitations using morphometric analyses 22 Phylogeny 26 Biogeography 26 Taxonomic treatment 29 Mandragora L 29 Key to the species of Mandragora 30 1. Mandragora officinarum L 30 2. Mandragora turcomanica Mizg 33 3. Mandragora caulescens C.B. Clarke 34 References 36 Exsiccatae 38 Taxonomic index ... 40 SYNOPSIS. The Old World genus Mandragora L. (Solanaceae) is revised for the first time across its entire geographical range. The introduction reviews the extensive mythological and medicinal as well as the taxonomic history of the genus. On morphological and phenological grounds three geographically widely disjunct species can be distinguished: the Mediterranean M. officinarum L., the narrowly local Turkmenian endemic M. turcomanica Mizg. and the Sino-Himalayan M caulescens C.B. Clarke. The generic monophyly of Mandragora L. as traditionally circumscribed is supported by cladistic analysis of morphological data. The ecological and historical phytogeography of the genus is discussed and alternative biogeographical scenarios are evaluated. Finally, a concise taxonomic treatment of the taxa is provided, based on the evidence of the preceeding analyses. INTRODUCTION The long history of mythology and medicinal use of the mandrake combined with the variable morphology and phenology have led to The nightshade family (Solanaceae) is a cosmopolitan but predomi- considerable confusion in the classification of Mandragora. -
Chemical Compound Outline (Part II)
Chemical Compound Outline (Part II) Ads by Google Lil Wayne Lyrics Search Lyrics Song Wayne Dalton Wayne's Word Index Noteworthy Plants Trivia Lemnaceae Biology 101 Botany Search Major Types Of Chemical Compounds In Plants & Animals Part II. Phenolic Compounds, Glycosides & Alkaloids Note: When the methyl group containing Jack's head is replaced by an isopropyl group, the model depicts a molecule of menthol. Back To Part I Find On This Page: Type Word Inside Box; Find Again: Scroll Up, Click In Box & Enter [Try Control-F or EDIT + FIND at top of page] **Note: This Search Box May Not Work With All Web Browsers** Go Back To Chemical VI. Phenolic Compounds Compounds Part I: VII. Glycosides Table Of Contents VIII. Alkaloids Search For Specific Compounds: Press CTRL-F Keys If you have difficulty printing out this page, try the PDF version: Click PDF Icon To Read Page In Acrobat Reader. See Text In Arial Font Like In A Book. View Page Off-Line: Right Click On PDF Icon To Save Target File To Your Computer. Click Here To Download Latest Acrobat Reader. Follow The Instructions For Your Computer. Types Of Phenolic Compounds: Make A Selection VI. Phenolic Compounds: Composed of one or more aromatic benzene rings with one or more hydroxyl groups (C-OH). This enormous class includes numerous plant compounds that are chemically distinct from terpenes. Although the essential oils are often classified as terpenes, many of these volatile chemicals are actually phenolic compounds, such as eucalyptol from (Eucalytus globulus), citronellal from (E. citriodora) and clove oil from Syzygium aromaticum. -
Poisonous Plants
Plants Poisonous Plants ACMT Board Review Course September 9, 2012 Thomas C. Arnold, M.D. 1 Special Acknowledgement • Thanks to Michelle Ruha and other previous presenters for their efforts on this topic. 2 Plants • Natural Products: 5% of tox boards – Includes food and marine poisonings, herbals, plants, fungi, toxic envenomations • ~ 5% of exposures reported to PCC each year, most in children < 6 years – Often a few deaths per year, but most reported exposures minor 3 1 Plants Plant Poisoning by Organ System • GI toxins • CNS toxins • Cardiovascular toxins • Multiorgan-system toxins • Hepatotoxins • Nephrotoxins • Endocrine toxins • Dermal and mucous membrane irritants 4 Lots of calls / Little threat • Euphorbia pulcherrima – Poinsettia • Ilex spp – Holly • Phoradendron spp – Mistletoe • Lantana spp • Spathiphyllum spp – Peace lily 5 • Ingestion of this plant may produce severe vomiting and diarrhea. Purple stains on fingers and a foamy quality to the diarrhea may provide a clue to the species of plant. Pokeweed AKA Phytolacca americana Toxin: phytolaccatoxin 6 2 Plants Phytolacca americana • Edible if parboiled • Root is the most toxic part, mature berries least toxic • Contains pokeweed mitogen – May see plasmacytosis • Supportive care 7 Wikivisual.com Solanum spp wiki • 1700 species; nightshade, potato • Poisoning usually from ingestion of immature fruit • Solanine glycoalkaloids – Usually produce GI irritant effects – Hallucinations and coma reported 8 Melia azedarach Toxin: meliatoxins Chinaberry9 3 Plants Chinaberry • Tree grows -
The Journey of Discovering Skull Base Anatomy in Ancient Egypt and the Special Influence of Alexandria
Neurosurg Focus 33 (2):E2, 2012 The journey of discovering skull base anatomy in ancient Egypt and the special influence of Alexandria ALI M. ELHADI, M.D., SamUEL KALB, M.D., LUIS PEREZ-ORRIBO, M.D., ANDREW S. LITTLE, M.D., ROBERT F. SpeTZLER, M.D., AND MARK C. PREUL, M.D. Division of Neurological Surgery, Barrow Neurological Institute, St. Joseph’s Hospital and Medical Center, Phoenix, Arizona The field of anatomy, one of the most ancient sciences, first evolved in Egypt. From the Early Dynastic Period (3100 BC) until the time of Galen at the end of the 2nd century AD, Egypt was the center of anatomical knowledge, in- cluding neuroanatomy. Knowledge of neuroanatomy first became important so that sacred rituals could be performed by ancient Egyptian embalmers during mummification procedures. Later, neuroanatomy became a science to be studied by wise men at the ancient temple of Memphis. As religious conflicts developed, the study of the human body became restricted. Myths started to replace scientific research, squelching further exploration of the human body until Alexander the Great founded the city of Alexandria. This period witnessed a revolution in the study of anatomy and functional anatomy. Herophilus of Chalcedon, Erasistratus of Chios, Rufus of Ephesus, and Galen of Pergamon were prominent physicians who studied at the medical school of Alexandria and contributed greatly to knowledge about the anatomy of the skull base. After the Royal Library of Alexandria was burned and laws were passed prohibiting human dissections based on religious and cultural factors, knowledge of human skull base anatomy plateaued for almost 1500 years. -
WINE and MEDICINE in ANCIENT GREECE in an Attempt to Dispel The
chapter ten WINE AND MEDICINE IN ANCIENT GREECE In an attempt to dispel the grief caused by the death of loved ones, Helen pours into the crater that was used for drinking an ingenious remedy that came from Egypt, the land of the most knowledgeable doctors in the world, who descend from Paeon, the doctor of the gods. This passage from the Odyssey (4,219f.) is well known, and is the rst attestation in Greek liter- ature of a remedy against love sickness. However, what is less well known is the reading of this passage by a Greek doctor who lived between Hip- pocrates and Galen, Rufus of Ephesus ( rst century ad), in a discussion of wine preserved in Oribasius:1 Wine is more praiseworthy for health than any other thing; however, anyone who drinks it must be wise, if he does not wish to sufer some irreparable ill; for wine can encourage heat, ll the body with strength and digest food from all parts; and there is no wine that is not harmful so as not to produce these efects; but it has, as all other things, some inferior qualities and some superior qualities. Wine can also give pleasure to the soul in a certain state, since it is the remedy (φάρµακον) against grief and, in my opinion, it is what Helen poured into the crater. This interpretatio graeca of the Egyptian remedy is most certainly incorrect, but it clearly shows the important place that wine occupied in the medical thought of ancient Greece. Wine was believed to be relevant to medicine in several ways. -
Treatment of Mental Illness in Post-Hippocratic Ancient Medicine
ENCEPHALOS 55, 36-41, 2018 Treatment of Mental Illness in Post-Hippocratic Ancient Medicine S. KOTSOPOULOS, MD, PhD, FRCPC* Summary Introduction The medical treatises of a number of physicians of The time period covered in the present study extends the Hippocratic tradition, which have survived to pos - from the 1 st to the 7 th century A.D. A number of terity, provide a record of concepts of mental illness - important physicians-writers flourished in the six cen - es and their management for Late Antiquity and the tury period. Among those who lived in the earlier cen - early centuries of Byzantium. The writings are con - turies, Aretaeus the Cappadocian (c. 50 A.D.)[1], sidered here of Early Byzantium physicians. A nosol - Soranus of Ephesus (c. 78-117 A.D.)[2], and Rufus of ogy landmark was provided early by Aretaeus and Ephesus[3], probably contemporary of Soranus, Caelius Aurelianus distinguishing acute and chronic have dealt with mental illness extensively. Galen of diseases. Ancient physicians considered the pathol - Pergamum (131-201 A.D.) presented his views on ogy of mental illness as being biological consequent - mental illness less systematically. Among his several ly the treatment was primarily biological although treatises none is dealing exclusively with them.[4] At environmental interventions were also considered. a later date other medical writers such as Oribasius Prevalent was the concept of imbalance of the body of Pergamum (c.325-400)[5], Aetius of Amida (6 th fluids [humors]. Primary objective of the intervention century A.D.[6], Alegander of Tralles (525-605 was the restoration of balance among the humors. -
The Journey of Discovering Skull Base Anatomy in Ancient Egypt and the Special Influence of Alexandria
Neurosurg Focus 33 (2):E2, 2012 The journey of discovering skull base anatomy in ancient Egypt and the special influence of Alexandria ALI M. ELHADI, M.D., SamUEL KALB, M.D., LUIS PEREZ-ORRIBO, M.D., ANDREW S. LITTLE, M.D., ROBERT F. SpeTZLER, M.D., AND MARK C. PREUL, M.D. Division of Neurological Surgery, Barrow Neurological Institute, St. Joseph’s Hospital and Medical Center, Phoenix, Arizona The field of anatomy, one of the most ancient sciences, first evolved in Egypt. From the Early Dynastic Period (3100 BC) until the time of Galen at the end of the 2nd century AD, Egypt was the center of anatomical knowledge, in- cluding neuroanatomy. Knowledge of neuroanatomy first became important so that sacred rituals could be performed by ancient Egyptian embalmers during mummification procedures. Later, neuroanatomy became a science to be studied by wise men at the ancient temple of Memphis. As religious conflicts developed, the study of the human body became restricted. Myths started to replace scientific research, squelching further exploration of the human body until Alexander the Great founded the city of Alexandria. This period witnessed a revolution in the study of anatomy and functional anatomy. Herophilus of Chalcedon, Erasistratus of Chios, Rufus of Ephesus, and Galen of Pergamon were prominent physicians who studied at the medical school of Alexandria and contributed greatly to knowledge about the anatomy of the skull base. After the Royal Library of Alexandria was burned and laws were passed prohibiting human dissections based on religious and cultural factors, knowledge of human skull base anatomy plateaued for almost 1500 years. -
Hallucinogens How Are They Taken?
Hallucinogens How are they taken? • Eaten – fresh or dried, crushed leaves or seeds, as a tea or decoc:on, smoked (a new world custom) • Snuffing – yopo, epena, ebil , rape dos indoios • Plant addi:ves – plants added to mix of other hallucinogens to prolong or intensify the effects. Hemispherical differences • Fewer examples from the old world that the new world. There are 15 to 20 species used in the Eastern Hemisphere but more than 100 in the Western. • Exepons from the Eastern Hemisphere would be Cannabis, Henbane, nightshade, Belladonna and Mandrake. Mushrooms • Amanita muscaria – used in northeastern Siberia • Taken alone or with reindeer milk or wild plants’ juice • Ac:ve compounds passed in urine • Said to be connected to Rig-Veda Mushrooms, con:nued • Psilocybe cubensis and other species. • Used in ancient ceremonies in Mexico • Visual and auditory hallucinaons, a disembodiment and intensificaon of senses Old world plants Cannabis • Old world in origin, nave to central Asia • Kif, Bhang, Charas, Marihuana, Hasheesh, Hemp • Some:mes called a “camp follower” because of its presence around human habitaons. • Cons:tuents concentrated in a resin of the female flower with much variaon from races and strains of the plant. • Ancient use across China and the middle east. Old World Plants Belladonna (Atropa belladonna) • Highly poisonous and hallucinogenic. • Part of medieval Europe’s witches brews. • A beauty aid in medieval Italy – as eye drops • Alkaloid hyoscyamine, scopolamine, the psychoac:ve component, and atropine Old world plants Henbane, Hyoscyamus niger • Another for the witches pot in old Europe • Hallucinaons and sensaon of flight • Alkaloid, Hyocyamine but also scopolamine Plants of the old World Mandrake Mandragora officinarum Mandrake • “Its complex history as a magic hypno:c in the folklore of Europe cannot be equaled by any species anywhere.