Prevalence and In-Hospital Outcome of Aspiration in Out-Of-Hospital Intubated Trauma Patients
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Zurich Open Repository and Archive University of Zurich Main Library Strickhofstrasse 39 CH-8057 Zurich www.zora.uzh.ch Year: 2017 Prevalence and in-hospital outcome of aspiration in out-of-hospital intubated trauma patients Radu, Raluca R DOI: https://doi.org/10.1097/MEJ.0000000000000465 Posted at the Zurich Open Repository and Archive, University of Zurich ZORA URL: https://doi.org/10.5167/uzh-143920 Dissertation Published Version Originally published at: Radu, Raluca R. Prevalence and in-hospital outcome of aspiration in out-of-hospital intubated trauma patients. 2017, University of Zurich, Faculty of Medicine. DOI: https://doi.org/10.1097/MEJ.0000000000000465 Zurich Open Repository and Archive University of Zurich Main Library Strickhofstrasse 39 CH-8057 Zurich www.zora.uzh.ch Year: 2017 Prevalence and in-hospital outcome of aspiration in out-of-hospital intubated trauma patients Radu, Raluca R; Kaserer, Alexander; Seifert, Burkhardt; Simmen, Hans-Peter; Ruetzler, Kurt; Spahn, Donat R; Neuhaus, Valentin DOI: https://doi.org/10.1097/MEJ.0000000000000465 Posted at the Zurich Open Repository and Archive, University of Zurich ZORA URL: https://doi.org/10.5167/uzh-136821 Veröffentlichte Version Originally published at: Radu, Raluca R; Kaserer, Alexander; Seifert, Burkhardt; Simmen, Hans-Peter; Ruetzler, Kurt; Spahn, Donat R; Neuhaus, Valentin (2017). Prevalence and in-hospital outcome of aspiration in out-of-hospital intubated trauma patients. European Journal of Emergency Medicine:Epub ahead of print. DOI: https://doi.org/10.1097/MEJ.0000000000000465 Original article 1 Prevalence and in-hospital outcome of aspiration in out-of-hospital intubated trauma patients Raluca R. Radua,*, Alexander Kaserera,*, Burkhardt Seifertc, Hans-Peter Simmenb, Kurt Ruetzlera,d, Donat R. Spahna and Valentin Neuhausb Objective The aim of this study was to evaluate the Injury Severity Score, and older age were independent prevalence for aspiration in out-of-hospital intubated predictors of 30-day mortality, but not aspiration. trauma patients and its impact on the in-hospital outcome. Conclusion Aspiration was frequent in out-of-hospital Patients and methods Medical records of out-of-hospital intubated trauma patients and was associated with higher intubated trauma patients, admitted from 2009 to 2014 to a mortality and less favorable outcome, but was not an level 1 trauma center, were retrospectively reviewed. independent predictor of mortality and morbidity. However, Patients younger than 18 years, treated with a supraglottic a low initial GCS on scene was shown to be an independent airway device, without a thorax computed tomography at predictor for aspiration and mortality. European Journal of admission, and with lung contusions were excluded. Two Emergency Medicine 00:000–000 Copyright © Wolters hundred and eighty-one patients were further analyzed. The Kluwer Health, Inc. All rights reserved. definition of aspiration was based on computer European Journal of Emergency Medicine 2017, 00:000–000 tomographic findings at admission. Variables were analyzed in multivariate logistic and Cox regression analyses. Keywords: aspiration, intubation, outcome, out-of-hospital, prevalence, trauma Results Aspiration occurred in 90 (32%) patients. The aInstitute of Anesthesiology, bDepartment of Surgery, Division of Trauma Surgery, mean Injury Severity Score was significantly higher in the University Hospital Zurich, cDivision of Biostatistics at Epidemiology, Biostatistics = and Prevention Institute, University of Zurich, Zurich, Switzerland and aspiration group (40 ± 26 vs. 33 ± 22, P 0.032), whereas the dDepartments of Outcome Research and General Anesthesiology, mean initial Glasgow Coma Scale (GCS) on scene was Anesthesiology Institute, Cleveland Clinic, Cleveland, Ohio, USA < significantly lower (5 ± 3 vs. 7 ± 4, P 0.001). In multivariate Correspondence to Valentin Neuhaus, MD, PD, Department of Surgery, Division of analysis, a lower initial GCS was a significant predictor for Trauma Surgery, University Hospital Zurich, Raemistrasse 100, 8091 Zurich, Switzerland Tel: + 41 44 255 11 11; fax: + 41 44 255 44 06; aspiration. Pneumonia, systemic inflammatory response e-mail: [email protected] syndrome, and sepsis occurred at similar frequencies. The = *Raluca R. Radu and Alexander Kaserer contributed equally to the writing of this 1-day (41 vs. 23%, P 0.003) and the 30-day mortality (53 vs. article. 34%, P = 0.003) were significantly higher in the aspiration group. In survival analysis, a lower initial GCS, a higher Received 14 November 2016 Accepted 6 March 2017 Introduction limited and the reported incidence ranges between 34 Early intubation on scene in trauma patients is indicated and 50% [6,7,10–12]. according to international trauma guidelines including Possible complications after aspiration are airway PHTLS, ATLS or ETC. Especially patients with trau- obstruction, Mendelson’s syndrome, pneumonia, or acute matic head injury or shock benefit from early intubation – respiratory distress syndrome (ARDS), which are asso- and controlled ventilation [1 3]. Furthermore, intubation ciated with prolonged ventilator weaning, ICU stay, and prevents pulmonary aspiration [4,5]. However, urgent increased mortality [12–14]. intubation per se is also associated with an increased risk of aspiration [6,7]. Trauma patients are often not fasted; The aim of this study was to evaluate the prevalence and blood, vomitus, or swelling may make it difficult to to investigate the impact of aspiration on in-hospital visualize the larynx and vocal cords. In addition, difficult outcome for out-of-hospital intubated trauma patients airway situations (face and neck trauma; constrained in a level 1 trauma center in Switzerland. mouth opening; cervical spine immobilization), low Glasgow Coma Scale (GCS), obesity, difficult environ- mental conditions (poor light; limited space), as well as Patients and methods inexperienced physicians can increase the risk of aspira- In a retrospective study, all inpatient medical records tion [8]. Previous studies have reported incidences from a level 1 trauma center in Switzerland between 2009 and 2014 were reviewed. The local ethical committee between 1 and 20% among various patient groups approved the study (KEK-ZH-No: 2011-0382). requiring emergent airway management in either the emergency department or the ICU [6,9]. In contrast, data In Switzerland, prehospital care in case of severely on pulmonary aspiration in the out-of-hospital setting are injured patients is usually provided by a medical doctor 0969-9546 Copyright © Wolters Kluwer Health, Inc. All rights reserved. DOI: 10.1097/MEJ.0000000000000465 Copyright r 2017 Wolters Kluwer Health, Inc. Unauthorized reproduction of this article is prohibited. 2 European Journal of Emergency Medicine 2017, Vol 00 No 00 (in our area usually an anesthesia resident) and a para- to compare aspiration, patient, and injury factors asso- medic team. Severely injured patients are transferred by ciated with mortality. Adjusted odds ratio with corre- ambulance or helicopter to one of 12 trauma centers. In sponding 95% confidence interval (CI) were tabulated. our trauma center, a standardized clinical approach is Statistical significance was set as a two-tailed P-value of provided in the resuscitation area, where severely injured less than 0.05. To answer the question of whether patients are usually admitted first. The standard approach aspiration is an independent risk factor for a negative in- consists of a primary survey and further treatment hospital outcome, time to mortality, time to death or according to ATLS or ETC is applied by the trauma staff complications, and time to extubation were included in including at least one senior and one junior anesthetist, survival Kaplan–Meier curves and compared with the one senior, and one junior trauma surgeon as well as log-rank Mantel–Cox test as well as in Cox regression several nurses. The whole-body computed tomography analyses while controlling for aspiration, age, sex, ISS, (CT) scan is considered the gold standard and is per- GCS, and comorbidities. Two variables (liver failure and formed in all major trauma patients as soon as possible to gastroesophageal reflux disease ) were excluded from the evaluate their relevant injuries and determine further multivariate analyses as they were always associated with treatment. one of the possible outcomes. All statistical analyses were All trauma patients who underwent out-of-hospital intu- carried out by IBM SPSS Statistics 22 (SPSS Inc., bation during the defined study period were included Chicago, Illinois, USA). (n = 434). Exclusion criteria were age younger than 18 years, supraglottic airway devices, no chest CT scan at admission, and lung contusions because of the difficulties in distinguishing contusions and aspiration on chest CT Results scan. A total of 281 trauma patients fulfilled the inclusion Demographics, prevalence of aspiration, and risk factors and exclusion criteria, were further analyzed, and divided for aspiration into an aspiration group and a no-aspiration group. Junior Ninety out of 281 (32%) of our trauma patients admitted and senior radiologists on call reviewed the CT scans. to our hospital had radiologic findings associated with Classic radiographic findings in acute aspiration included pulmonary aspiration. Demographics such as age, sex, ground glass opacity; perihilar, ill-defined, alveolar con- and source of admission were the same in both groups solidations; multifocal patchy