bioRxiv preprint doi: https://doi.org/10.1101/284828; this version posted January 15, 2019. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license. Title: Evolution of the D. melanogaster chromatin landscape and its associated proteins Authors and affiliations: Elise Parey(1, 2) and Anton Crombach*(1,3,4) (1) Center for Interdisciplinary Research in Biology (CIRB), Collège de France, CNRS, INSERM, PSL Université Paris, 75005 Paris, France (2) (current address) Institut de Biologie de l’Ecole Normale Supérieure (IBENS), Ecole Normale Supérieure, CNRS, INSERM, PSL Université Paris, 75005 Paris, France (3) (current address) Inria, Antenne Lyon La Doua, 69603 Villeurbanne, France (4) Université de Lyon, INSA-Lyon, LIRIS, UMR 5205, 69621 Villeurbanne, France Author for Correspondence (*): Anton Crombach, Inria, Antenne Lyon La Doua, 69603 Villeurbanne, France,
[email protected] 1 of 49 bioRxiv preprint doi: https://doi.org/10.1101/284828; this version posted January 15, 2019. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license. Abstract (240w, max 250w) In the nucleus of eukaryotic cells, genomic DNA associates with numerous protein complexes and RNAs, forming the chromatin landscape. Through a genome-wide study of chromatin- associated proteins in Drosophila cells, five major chromatin types were identified as a refinement of the traditional binary division into hetero- and euchromatin.