DOCSLIB.ORG

ANIMUA Pat 022

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
ANIMUA Pat 022 ANIMUA PaT 022 COLD SPRING HARBOR LABORATORY ANNUAL REPORT 1992 Cold Spring Harbor Laboratory Box 100 1 Bungtown Road Cold Spring Harbor, New York 11724 Book design Emily Harste Managing Editor Susan Cooper Editor Dorothy Brown Photography Margot Bennett, Herb Parsons, Edward Campodonico, Scott McBride, Julie Timmins Typography Marie Sullivan Front cover: Blackford Hall (Renovated 1992) (Photographby Margot Bennett) Back cover: Aerial view of Cold Spring HarborLaboratory (Photog- raph by Margot Bennett) Contents Officers of the Corporation/Board of Trustees v Governance and Major Affiliations vi Committeesvii Barbara McClintock (1902-1992) viii Taggert Whipple (1912-1992) xii DIRECTOR'S REPORT 1 DEPARTMENTAL REPORTS 23 Administration 25 Buildings and Grounds 28 Development 30 Library Services 34 Public Affairs 36 RESEARCH 41 Tumor Viruses43 Molecular Genetics of Eukaryotic Cells 85 Genetics 151 Structure and Computation 199 Neuroscience 227 CSH Laboratory Fellows249 Author Index253 COLD SPRING HARBOR MEETINGS 255 Symposium on Quantitative Biology259 Meetings263 EDUCATIONAL ACTIVITIES 289 Postgraduate Courses 291 Seminars325 Undergraduate Research327 Nature Study329 BANBURY CENTER 331 Director's Report333 Meetings 341 DNA LEARNING CENTER 371 COLD SPRING HARBOR LABORATORY PRESS 395 FINANCIAL STATEMENTS 401 FINANCIAL SUPPORT OF THE LABORATORY 407 Grants 409 Corporate Sponsor Program416 Capital Gifts417 Annual Contributions 421 Cold Spring Harbor Laboratory Association422 LABORATORY STAFF 431 Front row: D.L. Luke III, M.F. Gerry, T.J. Knight, J.D. Watson, B.D. Clarkson, M.D. Lindsay, L.J. Landeau Second row: W. Everdell, E.S. Marks, W.R. Miller, C.F. Dolan, S.M.C. Tilghman, G.R. Fink Third row: D.B. Pall, T.M. Jessell, T. Maniatis, D.A. Warner, T.A. Saunders Ill, W.S. Robertson Fourth row: G. Blobel, W.M. Cowan, 0. Smith, J. Warner, J.J. Phelan, Jr. Fifth row: J.R. Reese, E.A.F. Wimmer Not shown: J.A. Movshon, J.A. Steitz, D.C. Wiley, G.W. Cutting, Jr., W. Vander Poel Hatch, L.A. Hazen, D.H. Koch, R.L. Cummings, W.H. Page, H. Bentley Glass, T. Whipple Officers of the Corporation David L. Luke III, Chairman Mary D. Lindsay, Vice Chairman Mary Vander Poel Hatch, Secretary John R. Reese, Treasurer James D. Watson, Ph.D., Director G. Morgan Browne, Administrative Director Board of Trustees Scientific Trustees Individual Trustees GOnter Blobel, M.D., Ph.D. George W. Cutting, Jr. William S. Robertson Rockefeller University Oyster Bay, New York Huntington, New York Wm. Maxwell Cowan, Ph.D.,M.D. Charles F. Dolan Thomas A. Saunders III Howard Hughes Medical Institute Oyster Bay, New York Saunders Garonzik & Karp, L.P. Martha Farish Gerry Owen T. Smith, Esq. Gerald R. Fink, Ph.D. Mill Neck, New York Laurel Hollow, New York Whitehead Institute for Biological Research Wendy Vander Poel Hatch Douglas A. Warner III Oyster Bay, New York Oyster Bay, New York Thomas M. Jessell, Ph.D. James D. Watson, Ph.D. Columbia University Lita Annenberg Hazen New York, New York Cold Spring Harbor, New York J. Anthony Movshon, Ph.D. Townsend J. Knight, Esq. Howard Hughes Medical Institute, New York, New York New York University Center Honorary Trustees for Neural Science David H. Koch New York, New York Bayard D. Clarkson, M.D. Joan Argetsinger Steitz, Ph.D. New York, New York Laurie J. Landeau, V.M.D. Yale University Northport, New York Robert L. Cummings Glen Head, New York Shirley M. Caldwell Tilghman, Ph.D. Mary D. Lindsay Princeton University New York, New York Walter H. Page Cold Spring Harbor, New York Don Craig Wiley, Ph.D. David L. Luke III Harvard University New York, New York H. Bentley Glass, Ph.D. East Setauket, New York Eckard A.F. Wimmer, Ph.D. Edwin S. Marks State University of New York, New York, New York Taggart Whipple" Oyster Bay, New York Stony Brook William R. Miller New York, New York David B. Pall, Ph.D. Roslyn Estates, New York John J. Phelan, Jr. New York City, New York John R. Reese Cold Spring Harbor, New York * deceased, November, 1992 Governance and MajorAffiliations The Laboratory is governed by a 30-memberBoard of Trustees which meets three or four times a year. Authority to actfor the Board of Trustees between meetings is vested in the Executive Committee of the Boardof Trustees. The Executive Committee is composed of the Officers of the Boardplus any other members who may be elected to the Executive Committeeby the Board of Trustees. Additional standing and ad hoc committees are appointedby the Board of Trustees to provide guidance and advice in specific areas of the Laboratory'soperations. Representation on the Board of Trustees itself isdivided between community representatives and scientists from major researchinstitutions. The Laboratory is chartered as an educational andresearch institution by the Board of Regents of the Education Department of theState of New York. It is designated as a "public charity" by the Internal RevenueService. Committees Audit Development Nominating Townsend J. Knight, Chairman David L. Luke III, Chairman Mary D. Lindsay, Chairman Laurie J. Landeau, V.M.D. Wendy V.P. Hatch, Vice Chairman David L. Luke Ill William R. Miller G. Morgan Browne William R. Miller Thomas A. Saunders III George W. Cutting John R. Reese Gordon S. Hargraves Douglas A. Warner Ill Townsend J. Knight Banbury Program Laurie J. Landeau, V.M.D. Mary D. Lindsay Robertson House Eckard A.F. Wimmer, Ph.D., Chairman William R. Miller Gerald R. Fink, Ph.D. James D. Watson, Ph.D. William S. Robertson, Chairman Martha F. Gerry G. Morgan Browne Laurie J. Landeau, V.M.D. Anne Meier J. Anthony Movshon, Ph.D. Executive Committee Jan Witkowski, Ph.D. Jan A. Witkowski, Ph.D. Jack Richards David L. Luke Ill, Chairman G. Morgan Browne Building George W. Cutting Robertson Research Fund Wendy Vander Poel Hatch Helen A. Dolan, Chairman Townsend J. Knight John R. Reese, Chairman George W. Cutting Mary D. Lindsay G. Morgan Browne Martha F. Gerry William R. Miller David L. Luke Ill Wendy Vander Poel Hatch John J. Phelan Bruce Stillman, Ph.D. Mary D. Lindsay John R. Reese James D. Watson, Ph.D. Jack Richards Bruce Stillman, Ph.D. Owen T. Smith James D. Watson, Ph.D (Family Representatives) Elizabeth Watson Katherine Ernst Finance and Investment Townsend J. Knight Commercial Relations Walter Meier, M.D. John R. Reese, Chairman William S. Robertson William R. Miller, Chairman G. Morgan Browne Gerald R. Fink, Ph.D. Charles F. Dolan Townsend J. Knight William D. Keen Tenure and Appointments David H. Koch Townsend J. Knight Gerald R. Fink, Ph.D., Chairman David L. Luke Ill David H. Koch John Maroney Laurie J. Landeau, V.M.D. GOnter Blobel, M.D., Ph.D. John J. Phelan David L. Luke Ill Wm. Maxwell Cowan, M.D., Ph.D. Bruce Stillman, Ph.D. Edwin S. Marks Shirley M. Caldwell Tilghman, Ph.D. Don C. Wiley, Ph.D. Douglas A. Warner Ill William R. Miller William S. Robertson Thomas A. Saunders Ill Barbara McClintock 1902-1992 "Private Residence. Do Not Enter." These words, written in a plain hand on a small, aged, brown card thumbtacked to the door of Barbara McClintock's Hooper apartment, must have dissuaded many would-be proselytes. Others were intimidated by her presence. Although nearly everyone at the Laboratory in the last 50 years saw Barbara somewhere, in her laboratory, strolling the grounds, or at Laboratory functions, not everyone spoke to her. Strik- ing up a conversation with the legendary scientist required either courage or nerve. Small in size, of the minority gender in science, and averse to publicity, Barbara protected herself from outsiders with a reputation of reclusiveness. But those who raised a feather to this wall found it easily toppled. Behind it was a woman of great warmth, boundless intellectual energy, and open mind. She was willing to talk to anyone who really had something to say; her only in- tolerances were of stupidity and zealotry. Barbara was born on the 16th of June, 1902, in Hartford, Connecticut. Her parents, Sara Handy McClintock and Thomas Henry McClintock, were both from New England, but they had very different backgrounds. Barbara's mother came from one of the best familes in Hyannis, Massachusetts, and could trace her lineage on both sides back to the Mayflower. Her father was the son of British emigrants, a newcomer by his future in-laws' standards. When they were married, Thomas was still in medical school, and so the young couple had little money. They soon began having children, however, and Barbara was the third of four children. When Barbara was six, the family moved to Brooklyn. Barbara attended Erasmus Hall High School, and at age 17, she entered Cornell University's School of Agriculture in Ithaca, New York. She majored in botany, receiving her B.A. degree in 1923. Advanced degrees fol- lowed in quick succession: She earned an M.A. in 1925 and a Ph.D. in 1927. In the mid 1920s, genes were still abstract units of heredity. Geneticists widely accepted that genes were carried on the chromosomes, but the bricks and mortar of a gene, its physical basis, was not known. Barbara's dissertation was on cytogenetics, a new field that sought tolink pat- terns of inheritance to the behavior and structure of chromosomes. Her organism of choice was Zea mays, or maize, the colorful "Indian corn" familiar in Thanksgiving tablesettings. Maize was one of two primary organisms used in genetics at that time, the other being the fruit fly Drosophila, whose use was pioneered by Thomas Hunt Morgan. Maize was useful be- cause of the pigments that make its ears so appealing. The color patternsthese pigments produce can be easily tracked, both through the development of a particular ear and from generation to generation.
Load more

Recommended publications
  • ANNUAL REPORT 2019 1 Contents Director’S Letter 1
    Whitehead Institute ANNUAL REPORT 2019 1 Contents Director’s Letter 1 Chair’s Letter 3 Members & Fellows 4–5 Science 6 Community 44 Philanthropy 56 2 The Changing Face of Discovery For 37 years, Whitehead Institute has demonstrated an ability to drive scientific discovery and to chart paths into new frontiers of knowledge. Its continuing achievements are due, in substan- tial part, to the unique capacities and dedication of Members who joined the Institute in the 1980s and ‘90s — from Founding Members Gerald Fink, Harvey Lodish, Rudolf Jaenisch, and Robert Weinberg to those who followed, including David Bartel, David Sabatini, Hazel Sive, Terry Orr-Weaver, Richard Young, and me. Those long-serving Members continue to do pioneering science and to be committed teachers and mentors. Yet we have begun an inevitable genera- tional transition: In the last two years, Gerry and Terry have closed their labs, and Harvey will do so this coming year. The exigencies of time mean that, increasingly, Whitehead Institute’s ability to maintain its vigorous scientific leadership depends on our next generation of researchers. As I move toward the conclusion of my term as director, I am particularly proud of the seven current Members and the 14 Whitehead Institute Fellows we recruited during the last 16 years. The newest of those stellar researchers joined us in 2019: Whitehead Institute Member Pulin Li and Whitehead Fellow Kipp Weiskopf. Pulin studies how circuits of interacting genes in individu- al cells enable multicellular functions, such as self-organizing into complex tissues, and her research brilliantly combines approaches from synthetic biology, developmental and stem cell biology, biophysics, and bioengineering to study these multicellular behaviors.
    [Show full text]
  • LSU WIS October 2016 Newsletter
    Volume 1 | Issue 2 LSU Women in Science Oct. 31st, 2016 Thank you to everyone who attended our first meeting of the semester at the beginning of October! For those of you who couldn’t make it: We had a great conversation about the importance of women role models and mentors in positions of leadership and how that influences our own path in science. We are excited about the enthusiam and direction of LSU Women in Science and look forward to seeing you all at our next meeting! -Your LSU WIS Leadership Team The next meeting will be open to everyone. Come as you are and bring anyone you want. It doesn't matter if you're male, female, neutral, trans, gay, straight, black, white, brown, or purple, if you love science and want to be part of the conversation, join us! Fall 2016 meetings Meetings will be the first Tuesday of the month at 5pm! The December meeting will be a social – More information will be announced in the coming weeks! NEXT MEETING Tuesday Nov 1st @ 5pm Renewable and Natural “Life is not easy for any of Resources Building Rm 141 us. But what of that? We must have perseverance and above all confidence in ourselves. We must believe that we are gifted for something and that this thing must be attained.” – Marie Curie Contact us Kelcee Smith [email protected] Cassandra Skaggs [email protected] Julie Butler [email protected] Amie Settlecowski [email protected] WOMEN IN SCIENCE OCTOBER NEWSLETER 1 Perception of Women in Science: #distractinglysexy By Cassandra Skaggs Many of us recall the #distractinglysexy social media explosion that occurred in 2015 over Dr.
    [Show full text]
  • Barbara Mcclintock
    Barbara McClintock Lee B. Kass and Paul Chomet Abstract Barbara McClintock, pioneering plant geneticist and winner of the Nobel Prize in Physiology or Medicine in 1983, is best known for her discovery of transposable genetic elements in corn. This chapter provides an overview of many of her key findings, some of which have been outlined and described elsewhere. We also provide a new look at McClintock’s early contributions, based on our readings of her primary publications and documents found in archives. We expect the reader will gain insight and appreciation for Barbara McClintock’s unique perspective, elegant experiments and unprecedented scientific achievements. 1 Introduction This chapter is focused on the scientific contributions of Barbara McClintock, pioneering plant geneticist and winner of the Nobel Prize in Physiology or Medicine in 1983 for her discovery of transposable genetic elements in corn. Her enlightening experiments and discoveries have been outlined and described in a number of papers and books, so it is not the aim of this report to detail each step in her scientific career and personal life but rather highlight many of her key findings, then refer the reader to the original reports and more detailed reviews. We hope the reader will gain insight and appreciation for Barbara McClintock’s unique perspective, elegant experiments and unprecedented scientific achievements. Barbara McClintock (1902–1992) was born in Hartford Connecticut and raised in Brooklyn, New York (Keller 1983). She received her undergraduate and graduate education at the New York State College of Agriculture at Cornell University. In 1923, McClintock was awarded the B.S.
    [Show full text]
  • Mendel, No. 14, 2005
    THE MENDEL NEWSLETTER Archival Resources for the History of Genetics & Allied Sciences ISSUED BY THE LIBRARY OF THE AMERICAN PHILOSOPHICAL SOCIETY New Series, No. 14 March 2005 A SPLENDID SUCCESS As promised in this newsletter last year, the American Philosophical Society Library hosted the October 2004 conference, “Descended from IN THIS ISSUE Darwin: Insights into American Evolutionary Studies, 1925-1950”. In total, eighteen speakers and over thirty participants spent two days discussing the • The Correspondence of the Tring current state of scholarship in this area. Some papers focused on particular researchers and their theoretical projects. Others worked to place work from Museum at the Natural History the period into larger historical contexts. Professor Michael Ruse delivered Museum, London the keynote address, a popular lecture on the differences in emphasis when evolutionists present their work in public versus professional spheres. It • The Cyril Dean Darlington Papers was a capacity crowd and a roaring success. Thanks to the ‘Friends of the Library’ for the grand reception. • Joseph Henry Woodger (1894-1981) This conference had a real buzz about it. I had the sense we scholars Papers at University College London are on the brink of significant developments in our understanding of the period. Moreover, considerable progress is being made on how we might • Where to Look Next?: Agricultural relate this period to research underway in the decades before and after. New Archives as Resources for the History archives, new ideas, new opportunities. of Genetics As organiser, I’d like to express my thanks to the participants for the hard work done to prepare.
    [Show full text]
  • 158273443.Pdf
    Cover: A single cell from a mouse embryo, moving about on a glass slide. The cell was fixed and then stained with antibody to actomyosin, a contractile protein complexof muscle cells. The antibody was visualized by fluorescence, and its pattern revealed thatthe embryo cell contained actomyosin in sheaths, even though it was not a muscle cell. (Photo by B. Pollack, K. Weber, G. Felsten) ANNUAL REPORT 1974 COLD SPRING HARBOR LABORATORY COLD SPRING HARBOR, NEW YORK COLD SPRINGHARBOR LABORATORY Cold Spring Harbor, Long Island,New York OFFICERS OF THE CORPORATION Chairman: Robert H. P. Olney Secretary: Dr. Bayard Clarkson 1st Vice Chairman: Edward Pulling Treasurer: Angus P. McIntyre 2nd Vice Chairman: Arthur Trottenberg Assistant Secretary-Treasurer: William R. Udry Laboratory Director: Dr. James D. Watson Administrative Director: William R. Udry BOARD OF TRUSTEES INSTITUTIONAL TRUSTEES Albert Einstein College of Medicine New York University MedicalCenter Dr. Harry Eagle Dr. Milton R. J. Salton The City University of New York Princeton University Dr. Norman R. Eaton Dr. Bruce Alberts Columbia University The Rockefeller University Dr. James E. Darnell, Jr. Dr. Rollin Hotchkiss Duke UniversityMedical Center Sloan-Kettering Institute Dr. Robert E. Webster Dr. Bayard Clarkson Harvard MedicalSchool University of Chicago Dr. Charles A.Thomas, Jr. Dr. Robert Haselkorn Long IslandBiological Association University of Wisconsin Mr. Edward Pulling Dr. Julian Davies Massachusetts Wawepex Society Institute of Technology J. Knight Dr. HermanEisen Mr. Townsend INDIVIDUALTRUSTEES Dr. DavidP. Jacobus Colton P. Wagner Watson Mrs. GeorgeN. Lindsay Dr. James D. White Angus P.McIntyre Mrs. Alex M. A. Woodcock RobertH. P. Olney Mr. William WalterII. Page Honorary Trustees: Hollaender CharlesS.
    [Show full text]
  • STORIA DEL PENSIERO BIOLOGICO EVOLUTIVO Con Riflessioni Di Filosofia Ambientale
    STORIA DEL PENSIERO BIOLOGICO EVOLUTIVO con riflessioni di filosofia ambientale STORIA DEL PENSIERO BIOLOGICO EVOLUTIVO con riflessioni di filosofia ambientale Piergiacomo Pagano 2013 ENEA Agenzia nazionale per le nuove tecnologie, l’energia e lo sviluppo economico sostenibile Lungotevere Thaon di Revel, 76 00196 ROMA ISBN 978-88-8286-288-6 Foto in copertina In alto: fotografie di Fabio Conte Sfondo e riquadro: fotografie di Piergiacomo Pagano (Pellicani a Hervey Bay, Queensland, Australia, novembre 2003; Baobab, mousse du Senegal, febbraio 1991) STORIA DEL PENSIERO BIOLOGICO EVOLUTIVO con riflessioni di filosofia ambientale PIERGIACOMO PAGANO P. Pagano, Storia del Pensiero Biologico Evolutivo, ENEA INDICE Premessa …………………………………………………………………………………………..… 11 Introduzione ………………………………………………………………………………………… 13 1 Sui tre inspiegabili fatti che misero in dubbio la Creazione ……………………………………... 17 1.1 In antichità: cause finali e progetto …………………………………………………………...……... 17 1.2 L’età moderna ……………………………………………………………………………………...... 18 1.3 La grande diversità degli animali e delle piante …………………………………………………….. 19 1.4 Le palesi ingiustizie ……………………………………………………………………...………….. 20 1.5 La presenza di fossili inglobati nelle rocce ………………………………………………………..... 21 2 La Natura, gli organismi e la loro classificazione ……………………………………………...… 23 2.1 La classificazione in Platone …………………………………………………………………...…… 23 2.2 Classificazioni …………………………………………………………………………………...….. 25 2.3 Dopo Platone ………………………………………………………………………………………... 25 2.4 Aristotele e lo studio della Natura
    [Show full text]
  • Opcu V22 1930 31 01.Pdf (6.144Mb)
    CORNELL UNIVERSITY OFFICIAL PUBLICATION Volume XXII Number I Announcement of the New York State College of Agriculture for 1930-31 Ithaca, New York Published by the University July 1, 1930 THE CALENDAR FOR 1930-31 First Term 1930 Sept. i5 Monday Universityentrance examinations begin. Sept. 22 Monday Academic year begins. Registration of new students. Sept. 23 Tuesday 9-12 a. m. Registration of new students. 1-5 p. m. Registration of old students. Sept. 24 Wednesday Registration of old students. Sept. 25 Thurs. 8 a. m Instruction begins. Oct. 17 Friday Last day for payment of tuition. Nov. 5 Wednesday Registration of winter-course students. Nov. 27-29 Thanksgiving recess. Dec. 20 Sat. 12.50 p.m. Instruction ends in regular 1 93 1 and winter courses. I Christmas Jan. Mon. 8 a.m. Instruction resumed in recess. regular andwintercourses. Jan. n Sunday Birthday of Ezra Cornell. Founder's Day. Jan. 26 Monday Term examinations begin. Second Term Feb. 6 Friday [ Registration of all students. Feb. 7 Saturday Feb. 9 Mon. 8 a.m. Instruction begins in regular courses. Feb. 9-14 Farm and Home Week. Feb. 13 Friday Instruction ends in winter courses. Mar. 2 Monday Last day for payment of second-term tuition. Mar. 28 Sat. 12.50 p.m. Instruction ends. ) Spring Apr. 6 Mon. 8 a.m. Instruction resumed. ) recess. May 23 Saturday Spring Day, recess. June 1 Monday Term examinations begin. June 15 Monday Sixty-third Annual Commencement. NEW YORK STATE COLLEGE OF AGRICULTURE STAFF OF INSTRUCTION, RESEARCH, AND EXTENSION Livingston Farrand, A.B., M.D., L.H.D., LL.D., President of the University.
    [Show full text]
  • Plant Science Bulletin A
    PLANT SCIENCE BULLETIN A. Publication of the &tanical Societyof A.merica,Inc. VOLUME 3 JULY, 1957 NUMBER 3 Genetics, Corn, and Potato in the USSR ANTON LANG Department of Botany, Univ. of California. Los Angeles In April. 1956, the Soviet Russian government an- corn. He declared that, corn being a cross-pollinating nounced the resignation of T. D. Lysenko as president plant, inbreeding would lead to a "biological im- of the All-Union Lenin Academy of Agricultural poverishment of its genetical basis," that a "half-dead Science. This event signified theencL of the period of organism" would result, and that it would be impossible absolute domination which the so-called Soviet or to maintain inbred lines for more than 10 or 11 genera- Michurin-Lysenko genetics had enjoyed in the USSR. tions.2 He ridiculed the idea that crossing such inbreds This time therefore seemsappropriate for assessingsome could produce a superior plant. Instead, he advocated of the consequenceswhich the Lysenkoist experiment the use of varietal hybrids, asserting. in addition. that had for the USSR. The losses suffered by science can their hybrid vigor would not be limited to Fl' but be appreciated fairly easily. although it will probably would persist through F2 and Fs. take a long time before all details will be known. Any Under Lysenko's influence. breeding of hybrid corn person with some appreciation for the continuity of (in the "Western" sense) was completely abandoned scientific work can visualize how an experimental science in the USSR for more than 10 years, until 1947. when will be affected by eight years of almost total suppres- the All-Union Institute of Plant Industry (formerly sion.
    [Show full text]
  • BRIEF, August 2016]
    2016, BRIEF CV, Lee B. Kass (August 2016) 2016 CURRICULUM VITAE [BRIEF, August 2016] NAME: LEE B. KASS TITLE: Visiting Professor of Botany CORNELL CAMPUS Mailing ADDRESS: 412 Mann Library Building L. H. Bailey Hortorium, Plant Biology Section School of Integrative Plant Science Cornell University, Ithaca, NY 14853-4301 PHONE: Section office: 607-255-2131, Fax 607-255-7979 L. H. Bailey Hortorium, 440 Mann Library Building E-MAIL: [email protected]; http://plantbio.cals.cornell.edu/people/lee-kass Address for Correspondence: 1822 Pleasant Valley Rd, Fairmont, WV, 26554; Ph. 304-368-1408 Adjunct Professor, Plant Breeding & Genetics Section, School of Integrative Plant Science, College of Agriculture and Life Sciences, Cornell University, Ithaca, NY; http://plbrgen.cals.cornell.edu/people/lee-kass Adjunct Professor, Division of Plant & Soil Sciences, Davis College of Agriculture, West Virginia University, Morgantown, WV & Department of Biology, WVU Herbarium, Eberly College of Arts & Sciences, West Virginia University, Morgantown WV; http://plantandsoil.wvu.edu/faculty_staff/lee-kass WVU CAMPUS Mailing ADDRESS: Visiting Professor, Lee B. Kass; 3210 Agricultural Sciences Building Division of Plant and Soil Sciences, P.O. Box 6108 West Virginia University, Morgantown, WV 26505-6108 Division phone: 304-293-6023, [email protected] http://plantandsoil.wvu.edu/faculty_staff/lee-kass WVU Genetics and Developmental Biology Faculty: http://genetics.wvu.edu/gdb_faculty PSS Faculty/Staff: http://plantandsoil.wvu.edu/faculty_staff BACKGROUND EDUCATION
    [Show full text]
  • Laboratory Harbor Spring Cold Annual Report 1990
    YEAR CENTENNIAL THE LABORATORY HARBOR SPRING COLD ANNUAL REPORT 1990 COLD SPRING HARBOR LABORATORY THE CENTENNIAL YEAR ANNUAL REPORT 1990 Cold Spring Harbor Laboratory Box 100 1 Bungtown Road Cold Spring Harbor, New York 11724 Book design Emily Harste Editors Dorothy Brown, Lee Martin Photography Margot Bennett, Herb Parsons, Edward Campodonico Typography Marie Sullivan Front cover: Jones Laboratory, during the Centennial fireworks dis- play. This building, completed in 1893, was the first structure built expressly for science at Cold Spring Harbor. (Photograph by Ross Meurer and Margot Bennett.) Back Cover: (Top) Centennial reenactment of the first biology class at Cold Spring Harbor on board the launch "Rotifer." (Inset) The original class of 1890. Reenactments for the Centennial were directed by Rob Gensel. (Photograph by Randy Wilfong.) (Bottom) Centennial reenactment of the Laboratory's first biology class on the Jones Laboratory porch. (Inset) The original 1890 class on the porch of the old Fish Hatchery building before the completion of Jones Laboratory. (Photograph by Margot Bennett.) Contents Officers of the Corporation/Board of Trustees v Governance and Major Affiliations vi Committees vii Edward Pulling (1898-1991)viii DIRECTOR'S REPORT DEPARTMENTAL REPORTS 21 Administration 23 Buildings and Grounds 25 Development 28 Library Services 30 Public Affairs 32 RESEARCH 35 Tumor Viruses 37 Molecular Genetics of Eukaryotic Cells 93 Genetics 155 Structure and Computation 197 Neuroscience 213 CSH Laboratory Junior Fellows217 COLD SPRING
    [Show full text]
  • Transformation
    BNL-71843-2003-BC The Ptieumococcus Editor : E. Tuomanen Associate Editors : B. Spratt, T. Mitchell, D. Morrison To be published by ASM Press, Washington. DC Chapter 9 Transformation Sanford A. Lacks* Biology Department Brookhaven National Laboratory Upton, NY 11973 Phone: 631-344-3369 Fax: 631-344-3407 E-mail: [email protected] Introduction Transformation, which alters the genetic makeup of an individual, is a concept that intrigues the human imagination. In Streptococcus pneumoniae such transformation was first demonstrated. Perhaps our fascination with genetics derived from our ancestors observing their own progeny, with its retention and assortment of parental traits, but such interest must have been accelerated after the dawn of agriculture. It was in pea plants that Gregor Mendel in the late 1800s examined inherited traits and found them to be determined by physical elements, or genes, passed from parents to progeny. In our day, the material basis of these genetic determinants was revealed to be DNA by the lowly bacteria, in particular, the pneumococcus. For this species, transformation by free DNA is a sexual process that enables cells to sport new combinations of genes and traits. Genetic transformation of the type found in S. pneumoniae occurs naturally in many species of bacteria (70), but, initially only a few other transformable species were found, namely, Haemophilus influenzae, Neisseria meningitides, Neisseria gonorrheae, and Bacillus subtilis (96). Natural transformation, which requires a set of genes evolved for the purpose, contrasts with artificial transformation, which is accomplished by shocking cells either electrically, as in electroporation, or by ionic and temperature shifts. Although such artificial treatments can introduce very small amounts of DNA into virtually any type of cell, the amounts introduced by natural transformation are a million-fold greater, and S.
    [Show full text]
  • Friend of the Good Earth: [Dr. Reneㄆ Dubos]
    Rockefeller University Digital Commons @ RU Rockefeller University Research Profiles Campus Publications Summer 1989 Friend of the Good Earth: [Dr. ReneÌ Dubos] Carol L. Moberg Follow this and additional works at: http://digitalcommons.rockefeller.edu/research_profiles Part of the Life Sciences Commons Recommended Citation Moberg, Carol L., "Friend of the Good Earth: [Dr. ReneÌ Dubos]" (1989). Rockefeller University Research Profiles. Book 33. http://digitalcommons.rockefeller.edu/research_profiles/33 This Article is brought to you for free and open access by the Campus Publications at Digital Commons @ RU. It has been accepted for inclusion in Rockefeller University Research Profiles by an authorized administrator of Digital Commons @ RU. For more information, please contact [email protected]. THE ROCKEFELLER UNIVERSITY RESEARCH Gramicidin Crystals PROFILES SUMMER 1989 Friend ofthe Good Earth Fifty years ago, microbiologist Rene Dubos taught the world the principles offinding and producing antibiotics. His discovery of gramicidin in 1939, at The Rockefeller Institute for Medical Re­ search, represents the first systematic research and developmentof an antibiotic, from its isolation and purification to an analysis of how it cures disease. Gramicidin and its less pure fonn tyrothricin were the first antibiotics to be produced commercially and used clinically. They fonned the cornerstone in the antibiotic arsenal and remain in use today. This remarkable achievement was not Dubos's first, last, or even his most important contribution. To Rene Dubos, a living Rene Dubas (1901-1982) organism-microbe, man, society, or eanh--eould be under­ stood only in the context of the relationships it forms with everything else. This ecologic view led him from investigating problems ofsoil microbes to those ofspecific infectious diseases, to social aspects of disease, and, finally, to large environmental issues affecting the whole earth.
    [Show full text]