Authors: Pallavi Subhraveti Ron Caspi Peter Midford Peter D Karp An online version of this diagram is available at BioCyc.org. Biosynthetic pathways are positioned in the left of the cytoplasm, degradative pathways on the right, and reactions not assigned to any pathway are in the far right of the cytoplasm. Transporters and membrane proteins are shown on the membrane. Ingrid Keseler Periplasmic (where appropriate) and extracellular reactions and proteins may also be shown. Pathways are colored according to their cellular function. Gcf_000190595Cyc: Cellulophaga lytica DSM 7489 Cellular Overview Connections between pathways are omitted for legibility. Anamika Kothari

phosphate molybdate

RS04350 RS08315

phosphate molybdate

Macromolecule Modification tRNA-uridine 2-thiolation inosine 5'- Nucleoside and Nucleotide Degradation ditrans,octacis- a peptidoglycan with ditrans,octacis- a [bis(guanylyl an N-terminal- a [protein] and selenation (bacteria) phosphate guanosine ditrans,octacis- (4R)-4-hydroxy- an L-asparaginyl- an L-cysteinyl- Aminoacyl-tRNA Charging tRNA charging nucleotides undecaprenyldiphospho- (L-alanyl-γ-D-glutamyl- undecaprenyldiphospho- undecaprenyldiphospho- molybdopterin) cys L-methionyl-L- C-terminal glu degradation 2-oxoglutarate [tRNA Asn ] [tRNA Cys ] degradation III N-acetyl-(N-acetyl-β-D- L-lysyl-D-alanyl-D- N-acetyl-(N- N-acetyl-(N- cysteinyl-[protein] L-glutamate cys glucosaminyl)muramoyl- alanine) pentapeptide acetylglucosaminyl) acetylglucosaminyl) chaperone]- Phe IMP bifunctional phe a tRNA L-alanyl-γ-D-glutamyl-L- muramoyl-L-alanyl-γ- muramoyl-L-alanyl- L-cysteine cysteine IMP GMP type I methionyl 4-hydroxy-2- aminoacyl- aminoacyl- 30S lysyl-D-alanyl-D-alanine D-isoglutaminyl-N-(β- γ-D-isoglutaminyl- desulfurase: dehydrogenase: 5'/3'- aminopeptidase: oxoglutarate tRNA tRNA ribosomal nucleotidase D-asparaginyl)-L-lysyl- N-(β-D-asparaginyl) map phenylalanine- CELLY_RS00120 guaB cysteine aldolase/2- : hydrolase: protein gln a tRNA Gln SurE: surE D-alanyl-D-alanine -L-lysyl-D-alanine -tRNA XMP purine ribonucleosides degradation penicillin-binding desulfurase: type I methionyl dehydro-3-deoxy- arfB arfB S6--L- a tRNA Ala ala tRNA asp asp ser a tRNA ser cysteine guanosine subunit elongator protein 2: CELLY_RS07620 aminopeptidase: phosphogluconate aminoacyl-tRNA aminoacyl-tRNA glutamate his a tRNA His lys a tRNA Lys leu a tRNA Leu tyr a tRNA Tyr ile a tRNA Ile gly a tRNA Gly glu a tRNA glu trp a tRNA Trp met initiator tRNA Met met asn tRNA Asn arg a tRNA Arg cys a tRNA Cys pro a tRNA Pro thr a tRNA Thr desulfurase: alpha: pheS tRNA Met 5'/3'- CELLY_RS03925 penicillin-binding penicillin-binding cysteine map aldolase: hydrolase: hydrolase: ligase: rimK Val glutamine-- CELLY_RS07620 val a tRNA nucleotidase purine-nucleoside protein 2: protein 2: CELLY_RS08885 alanine- phenylalanine- tRNA ligase/ aspartate- serine- an [L-cysteine adenosine desulfurase: CELLY_RS11880 CELLY_RS08885 SurE: surE : a peptidoglycan with di-trans,octa-cis CELLY_RS03925 CELLY_RS03925 histidine-- lysine- -tRNA leucine-- tyrosine-- isoleucine-- glycine-- -tRNA ligase YqeY domain glutamate-- tryptophan- -tRNA methionine- methionine- -tRNA asparagine- arginine-- cysteine-- proline-- threonine- desulfurase]-S- CELLY_RS00120 an N-terminal L- a [protein] C- CELLY_RS04065 (L-alanyl-γ-D-glutamyl- -undecaprenyl α tRNA ligase: valine--tRNA ligase: -tRNA ligase: tRNA ligase: tRNA ligase: tRNA ligase: tRNA ligase: subunit beta: fusion protein: tRNA ligase: -tRNA ligase: -tRNA -tRNA ligase: -tRNA tRNA ligase: tRNA ligase: tRNA ligase: -tRNA sulfanyl-L-cysteine met cysteinyl-[protein] terminal -L- xanthosine L-lysyl-D-alanyl-D- diphosphate a peptidoglycan di-trans,octa-cis a peptidoglycan di-trans,octa-cis a [bis(guanylyl glyoxylate pyruvate tRNA Asn a tRNA Cys glutamate-α- CELLY_RS01540 CELLY_RS02920 ligase: lysS alaS CELLY_RS04560 CELLY_RS04990 CELLY_RS05395 CELLY_RS05525 CELLY_RS13435 CELLY_RS06660 CELLY_RS06670 ligase: trpS aspS ligase: metG ligase: metG serS ligase: asnS CELLY_RS10940 CELLY_RS11550 CELLY_RS11585 ligase: thrS guanine asn cys alanine) pentapeptide dimer (E. faeciums) -undecaprenyl dimer (E. faecium -undecaprenyl ala molybdopterin) L-glutamate an L-methionyl- diphosphate , tetrapeptide) diphosphate cofactor an L-histidyl- an L-valyl- an L-lysyl- an L-alanyl- an L-leucyl- an L-tyrosyl- an L-isoleucyl- an L-phenylalanyl- an L-glutaminyl- an L-glutamyl- an L-tryptophanyl- an L-aspartyl- an L-methionyl- an L-seryl- an L-asparaginyl- an L-arginyl- an L-cysteinyl- an L-prolyl- an L-threonyl- a [TusA sulfur- purine-nucleoside a glycyl-[tRNA Gly ] [elongator chaperone]-S- [tRNA His ] [tRNA Val ] [tRNA Lys ] [tRNA Ala ] [tRNA Leu ] [tRNA Tyr ] [tRNA Ile ] [tRNA Phe ] [tRNA Gln ] [tRNA Glu ] [tRNA Trp ] [tRNA asp ] [initiator tRNA Met ] [tRNA ser ] [tRNA Asn ] [tRNA Arg ] [tRNA Cys ] [tRNA Pro ] [tRNA Thr ] carrier protein]-S- phosphorylase: xanthosine adenosine inosine guanosine tRNA Met ] sulfanyl-L-cysteine CELLY_RS04065 sulfanyl-L-cysteine

xanthine xanthine purine-nucleoside purine-nucleoside purine-nucleoside purine-nucleoside a mature peptidoglycan a methylated sn-glycero-3- an N-terminal- 6-O-trans- an N-terminal- a peptide with an N-modified a [protein]-L- a [TusD sulfur- phosphorylase: phosphorylase: phosphorylase: phosphorylase: (meso-diaminopimelate 2-oxoglutarate nucleobase phospho-N- L-methionyl-L- methoxy-mycolyl- L-methionyl-L- an N-terminal aminoacyl-[tRNA] methionine carrier protein]-S- CELLY_RS04065 CELLY_RS04065 CELLY_RS04065 CELLY_RS04065 containing) within DNA (arachidonoyl) threonyl-[protein] trehalose 6- alanyl-[protein] L-methionine peptide- sulfanyl-L-cysteine ethanolamine phosphatebifunctional methionine α-D-ribose- (S)-S-oxide urate urate endolytic alpha-ketoglutarate- aminoacyl- type I methionyl alpha,alpha- type I methionyl type I methionyl [2Fe-2S] iron-sulfur Cofactor, Carrier, and Vitamin 1-phosphate dependent reductase superpathway of tetrahydrofolate biosynthesis superpathway of coenzyme A biosynthesis I (bacteria) superpathway of thiamine diphosphate biosynthesis I thiamine diphosphate transglycosylase glycerophosphoryl tRNA aminopeptidase: trehalose- aminopeptidase: aminopeptidase: cluster biosynthesis UTP and CTP dephosphorylation I C1 Compound Utilization MsrA: msrA biosynthesis II (Bacillus) a [TusE sulfur MltG: mltG dioxygenase AlkB: diester hydrolase: map phosphate map map Metabolic Regulator Biosynthesis and Assimilation CELLY_RS08110 synthase (UDP- peptide- 3-methyl-2- a 5,10- a uridine 34 in tRNA carrier protein]-S UTP [+ 2 isozymes] phosphodiesterase: arfB type I methionyl type I methionyl type I methionyl L-cysteine desulfurase cys methionine GTP oxobutanoate methylenetetrahydrofolate HMP-PP -sulfanylcysteine D-ribose 5- formaldehyde oxidation alpha-ketoglutarate- CELLY_RS04240 aminoacyl-tRNA aminopeptidase: forming)/trehalose- aminopeptidase: aminopeptidase: thiamine trehalose biosynthesis I pyrimidine deoxyribonucleotides dependent phosphatase: (S)-S-oxide ppGpp metabolism phosphate CTP synthase: VII (THF pathway) a mature peptidoglycan a mature peptidoglycan glycerophosphodiester hydrolase: map map map cysteine cysteine phosphate tRNA 2- dephosphorylation dioxygenase AlkB: trehalose- CELLY_RS12785 reductase 3-methyl-2-oxobutanoate CELLY_RS01085 with (L-alanyl-γ-D- strand (non- phosphodiesterase: CELLY_RS08885 desulfurase: GTP desulfurase: D-glucopyranose nucleoside triphosphate CELLY_RS14395 trans-methoxy- MsrA: msrA hydroxymethyltransferase: synthase: UDP-α-D-glucose thiouridine(34) formaldehyde glutamyl-meso-2,6- reducing terminus) CELLY_RS02790 CELLY_RS00120 cyclohydrolase CELLY_RS00120 6-phosphate pppGpp pyrophosphohydrolase: UDP an N-terminal L- mono-mycolate an N-terminal L- a protein-L- panB CELLY_RS09390 synthase CTP diaminopimeloyl-D- cysteine I FolE: folE cysteine mazG met threonyl-[protein] met alanyl-[protein] met a peptide methionine- asp thiamine MnmA: mnmA a nucleobase an N-modified an uncharged [+ 3 isozymes] bifunctional (p)ppGpp alanine) tetrapeptide formaldehyde succinate (S)-S-oxide desulfurase: desulfurase: bifunctional nucleotide a 5,10- within DNA sn-glycerol tRNA 7,8- 2-dehydropantoate phosphate synthetase/guanosine- anandamide CELLY_RS07620 CELLY_RS07620 alpha,alpha- guanosine 3'- 34 pyrophosphohydrolase: dihydroneopterin aspartate 1- synthase: 3',5'-bis(diphosphate) 3'- a 2-thiouridine UMP methylenetetrahydrofolate 3-phosphate an [L-cysteine trehalose- diphosphate 5'- CELLY_RS10010 an S-sulfanyl-[L- 3'-triphosphate decarboxylase: thiE cytidylyl molybdenum in tRNA CDP bifunctional 5,10- 2-dehydropantoate desulfurase]-S- pyrophosphohydrolase: triphosphate 3'- dCTP dCMP 5'/3'- cysteine desulfurase] flavin biosynthesis I (bacteria and plants) CELLY_RS05305 thiamine cofactor sulfurylation phosphate tRNA uridine-5- methylenetetrahydrofolate 2-reductase: ilvC sulfanyl-L-cysteine CELLY_RS01370 diphosphatase: nucleotidase ditrans,octacis- a [ThiI sulfur- 6-O-trans-keto- an N-terminal- (3R,5S)-3- phosphate synthase (UDP- carboxymethylaminomethyl(34) succinate cysteine cytidylyl molybdenum dehydrogenase/5,10- a 5,10- a uridine 34 a ferrocytochrome stearoyl-CoA H O mycolyl-trehalose β-alanine forming)/trehalose- CELLY_RS01370 dUTP diphosphatase: dut SurE: surE gly undecaprenyldiphospho- carrier protein]- cys 2 L-methionyl-L- semialdehyde hydroxy-1- (R)-pantoate desulfurase: thiamine- synthesis GTPase MnmE: mnmE methenyltetrahydrofolate b GTP a [ThiS sulfur- cofactor (trioxo) methylenetetrahydrofolate in tRNA 5 L-cysteine 6-phosphate seryl-[protein] NAD-dependent pyrroline-5- 7,8- phosphate phosphatase: [+ 2 isozymes] CMP N-acetyl-(N- bifunctional GTP CELLY_RS00120 carrier protein] tRNA uridine-5- dUTP uridine cyclohydrolase: succinate- carboxylatepyrroline-5- an S-sulfanyl-[cysteine dihydroneopterin AIR : thiL CELLY_RS12785 dUMP acetylglucosaminyl) alpha,alpha- GTP carboxymethylaminomethyl(34) 5'/3'- CELLY_RS10975 desulfurase]-[disordered- 3'-phosphate chorismate pantoate--beta- cysteine an [MCD cofactor ppGpp tRNA uridine-5- acyl-CoA muramoyl-L-alanyl-γ-D- cysteine type I methionyl semialdehyde carboxylate GTP NAD de novo biosynthesis thiamine synthesis MnmG: mnmG nucleotidase ribosome trehalose- alanine ligase: phosphomethylpyrimidine desulfurase: chaperone]-MCD α α a 5,10- desaturase: isoglutaminyl-L-lysyl- desulfurase: dehydrogenase: reductase: form scaffold cyclohydrolase II (from tryptophan) , -trehalose SurE: surE carboxymethylaminomethyl(34) biogenesis phosphate aminopeptidase: aminodeoxychorismate/ CELLY_RS05300 synthase ThiC: thiC CELLY_RS07620 diphosphate a 5-carboxymethylaminomethyl- 5-hydroxy-CTP 5-hydroxy-CMP methenyltetrahydrofolate (glycyl) -D-alanyl-D-alanine CELLY_RS07955 proC protein] complex cysteine 6-phosphate synthesis GTPase MnmE: mnmE CELLY_RS03205 5 CELLY_RS07620 synthase (UDP- map II: ribB a carboxy- nucleoside- 34 GTPase [cysteine desulfurase]-S- anthranilate synthase D-glyceraldehyde a [ThiI sulfur- 2-thiouridine in tRNA cytidine bifunctional 5,10- D-erythro-7,8- 2,5-diamino-6- trp HMP-P desulfurase: diphosphate tRNA uridine-5- acyl-CoA cysteine Der: der forming)/trehalose- type I methionyl NAD-dependent pyrroline-5- sulfanylcysteine:[acceptor component II: carrier protein]-S- adenylated-[ThiS bifunctional GDP methylenetetrahydrofolate dihydroneopterin (5-phospho-D- (R)-pantothenate tryptophan 2,3- 3-phosphate tyr CELLY_RS00120 kinase: bifunctional (p)ppGpp queuosine carboxymethylaminomethyl(34) desaturase: penicillin-binding desulfurase: [+ 5 isozymes] phosphatase: aminopeptidase: succinate- carboxylate protein]-cysteine CELLY_RS02760 sulfanyl-L-cysteine sulfur-carrier protein] alpha,alpha- pyrophosphokinase: purine deoxyribonucleosides degradation I dehydrogenase/5,10- ribosylamino) dioxygenase: bifunctional 1-deoxy-D-xylulose- cysteine CELLY_RS01305 synthetase/guanosine- biosynthesis I (de novo) synthesis enzyme MnmG: mnmG CELLY_RS14550 protein 2: CELLY_RS00120 trehalose-CELLY_RS12785 map semialdehyde reductase: sulfurtransferase: dihydroneopterin trehalose- CELLY_RS01370 methenyltetrahydrofolate aminodeoxychorismate pyrimidin- type III CELLY_RS05440 hydroxymethylpyrimidine 5-phosphate 2-iminoacetate desulfurase: 3',5'-bis(diphosphate) 3'- a 5-aminomethyl-2- CELLY_RS03925 trans-keto- dehydrogenase: proC CELLY_RS00120 aldolase: folB N-Formyl-L- phosphate cyclohydrolase: H + synthase 4(3H)-one pantothenate synthase: synthase 34 phosphate CELLY_RS12475 Hyp a [cysteine desulfurase]- kinase/ CELLY_RS07620 synthase (UDP- pyrophosphohydrolase: thiouridine in tRNA preQ 34 a [ThiI sulfur- GDP mono-mycolate kynurenine 0 2'-deoxyinosine 2'-deoxyadenosine 2'-deoxyguanosine CELLY_RS10975 a 5-carboxymethylaminomethyluridine an N-terminal + + 6-(hydroxymethyl) component I: pabB bifunctional kinase: phosphomethylpyrimidine CELLY_RS08295 ThiH: thiH a [cytidylyl molybdenum CELLY_RS01370 a 7,8-dihydrofolate a ferricytochrome oleoyl-CoA a peptidoglycan di-trans,octa-cis H RS09165 H S-sulfanyl-[disordered- a thiocarboxylated- thioredoxin forming)/trehalose- in tRNA ala carrier protein]- met L-seryl-[protein] succinate -7,8-dihydropterin diaminohydroxyphosphoribosylaminopyrimidine CELLY_RS04040 cofactor chaperone]- an N 10 - b form scaffold 4-amino-4- kinase: CELLY_RS06280 1-deoxy-D-xylulose [ThiS sulfur- phosphatase: GDP 5 dimer (S. aureus) -undecaprenyl S-sulfanyl- 2-amino-4-hydroxy-6- deaminase/5-amino-6-(5-phosphoribosylamino) 2-iminoacetate pathway cytidylyl molybdenum formyltetrahydrofolate protein] complex deoxychorismate (R)-4'- bifunctional 5-phosphate carrier protein] CELLY_RS12785 preQ diphosphate L-cysteine cysteine hydroxymethyldihydropteridine uracil reductase RibD: ribD phosphopantothenate cofactor (sulfo-dioxo) a 5-methylaminomethyl- 1 purine-nucleoside purine-nucleoside purine-nucleoside hydroxymethylpyrimidine an oxidized formyltetrahydrofolate H + RS10250 H + desulfurase: diphosphokinase: folK 5-amino-6-(5- α α 2-thiouridine 34 in tRNA phosphorylase: phosphorylase: phosphorylase: bifunctional L-kynurenine kinase/ thiazole synthase: thioredoxin , -trehalose tRNA deformylase: purU CELLY_RS00120 phospho-D- CELLY_RS04065 CELLY_RS04065 CELLY_RS04065 an sn-glycero-3- a [protein]- 6-O-cis-methoxy- an N-terminal- (7,8-dihydropterin- phosphopantothenoylcysteine CELLY_RS09380 guanosine(34) phosphomethylpyrimidine hydrogen selenide diphosphate H O phospho-N-(acyl) FAD aci-nitroethane mycolyl-trehalose L-methionyl-L- sec ribosylamino)uracil kynurenine 3- O-acetyl-L-serine 2 L-threonine ATP roseoflavin ser a tRNA cysteine 6-yl)methyl 4-aminobenzoate decarboxylase/ kinase: thiD transglycosylase formate D-ribulose bifunctional monooxygenase: 2-[(2R,5Z)-2-carboxy- 2-deoxy-α-D- ethanolamine 6-phosphate valyl-[protein] + + desulfurase: diphosphate phosphopantothenate-- thiamine diphosphate salvage II Tgt: tgt bifunctional 5'-phosphate H RS08950 H diaminohydroxyphosphoribosylaminopyrimidine thioredoxin- lipoate biosynthesis a 5-methylaminomethyl- CELLY_RS07620 5-phosphate CELLY_RS02995 HMP-PP 4-methylthiazol-5(2H)- Polyprenyl Biosynthesis a 7-aminomethyl-7- ribose 1-phosphate alpha,alpha- an S-sulfanyl-[cysteine cysteine ligase CoaBC: coaBC disulfide and incorporation I 2-(S-geranyl) inorganic FAD:protein FMN nitronate dihydropteroate deaminase/5-amino-6-(5-phosphoribosylamino) ylidene]ethyl phosphate deazaguanosine 34 O-acetylhomoserine glycerophosphodiester trehalose- type I methionyl serine- 3,4- (R)-4'- 3-hydroxy- 4-amino-2-methyl-5- thiouridine 34 in tRNA : monooxygenase: desulfurase]-S- synthase: folP uracil reductase RibD: ribD reductase: aminocarboxypropyltransferase/ diphosphatase: bifunctional dihydroxy-2- L-kynurenine pyrimidinemethanol in tRNA phosphodiesterase: CELLY_RS01070 phosphate aminopeptidase: -tRNA sulfanyl-[disordered- 5-amino-6-(5- phosphopantothenoyl- trxB an octanoyl-[acp] di-trans,poly-cis : CELLY_RS09840 CELLY_RS01960 kinase/ F0F1 ATP thiamine CELLY_RS02790 synthase (UDP- map ligase: H + H + butanone-4- phospho-D- L-cysteine bifunctional -undecaprenyl tRNA preQ1(34) S- FAD:protein FMN nitronate form scaffold 7,8- kynureninase: phosphate lipoyl(octanoyl) CELLY_RS09870 sodium-translocating forming)/trehalose- FAD synthetase: serS synthase phosphate ribitylamino)uracil bifunctional hydroxymethylpyrimidine phosphate biosynthesis Secondary Metabolite Biosynthesis adenosylmethionine Amino Acid Degradation glycerophosphoryl transferase: monooxygenase: type I methionyl protein] complex dihydropteroate kynU synthase: NADP transferase a 5-methylaminomethyl- cysteine synthase pyrophosphatase: phosphatase: CELLY_RS08870 [cysteine desulfurase]-S- synthase: phosphopantothenoylcysteine kinase/ a reduced ribosyltransferase- diester CELLY_RS03135 CELLY_RS05340 aminopeptidase: CELLY_RS09390 a [lipoyl-carrier LipB:protein] lipB (2E,6E)-farnesyl 2-(Se-phospho) CysM: cysM CELLY_RS09845 CELLY_RS12785 sulfanylcysteine:[acceptor bifunctional ribB decarboxylase/ biosynthesis phosphomethylpyrimidine thioredoxin IPP fluoroacetate and QueA: queA phosphodiesterase: trehalose- map 6 diphosphate 34 L-leucine degradation I an L-seryl- F0F1 ATP folylpolyglutamate 3-hydroxyanthranilate thiamine N -octanoyl-L-lysine preQ biosynthesis selenouridine in tRNA 34 roseoflavin + + protein]-cysteine 1-deoxy-L- 0 an epoxyqueuosine L-histidine degradation I L-serine degradation CELLY_RS04240 cis-methoxy- sec H H phosphopantothenate-- + kinase: CELLY_RS06280 fluorothreonine biosynthesis synthase RS01715 fluoride phosphate NAD L-methionine degradation a [protein]-FMN- adenine [tRNA ] sulfurtransferase: synthase/ glycero-tetrulose cysteine ligase CoaBC: coaBC 3-hydroxyanthranilate lipoyl in tRNA acetate acetaldehyde nitrite mono-mycolate ARP bacillithiol biosynthesis bifunctional isoprenyl L-selenocysteine H + an N-terminal dinucleotide CELLY_RS00120 dihydrofolate 4-phosphate synthase: thiE inorganic I (to L-homocysteine) phosphate AMP L-threonine a [cysteine 3,4-dioxygenase: synthase: lipA transferase: fluoride tRNA leu an N- met L-valyl-[protein] synthase: 4'-phosphopantetheine polyphosphate/ hydroxymethylpyrimidine GTP a 5-methylaminomethyl- his ser sn-glycerol desulfurase]-(S- UDP-N-acetyl- CELLY_RS05680 a [lipoyl-carrier epoxyqueuosine(34) branched-chain a metal a metal (S)-malate kinase/ CELLY_RS09775 34 3-phosphate acylethanolamine RS09585 CELLY_RS10265 6,7-dimethyl-8- 2-amino-3- ATP-NAD kinase: 6 SAM-dependent GTP 2-selenouridine histidine met L-serine sulfanyl) -[disordered- α-D-glucosamine thiamine phosphate phosphomethylpyrimidine protein]-N -[(R)- reductase QueG: queG amino acid cation cation 2 ribityllumazine pantetheine- CELLY_RS09770 chlorinase/ in tRNA ammonia- ammonia-: 7,8-dihydrofolate carboxymuconate- dihydrolipoyl]-L-lysine cyclohydrolase 34 methionine form scaffold phosphate kinase: thiD di-trans,octa-cis a queuosine aminotransferase: monoglutamate synthase: 6-semialdehyde NAD kinase: : I FolE: folE lyase: hutH adenosyltransferase: 2-aminoprop-CELLY_RS13485 protein] complex N-acetyl- adenylyltransferase: thiamine- -undecaprenyl in tRNA 4-methyl-2-CELLY_RS01695 urocanate a [ribosomal 3-aci- a mature DNA with adenine:7,8- phosphoenol an N-terminal- CELLY_RS01280 CELLY_RS09765 CELLY_RS16045 7,8- a sulfurated 34 alpha-D- phosphate HMP-P diphosphate [+ 3 isozymes] CELLY_RS09865 2-enoate protein S12] glycerophosphoserine peptidoglycan dihydro-8- L-methionyl- a cytidine lys a metal a metal coaD + oxopentanoate nitropropanoate (n) pyruvate RS11465 NADP dihydroneopterin SAM [sulfur carrier] dGDP ATP Ile2 glucosaminyl kinase: thiL undecaprenyl- 5'-deoxy-5'- urocanate L-aspartate 89 (meso-DAP oxoguanine mismatch glycyl-[protein] biotin in tRNA cation cation 6,7-dimethyl-8-(1- 3'-dephospho- 3'-triphosphate bifunctional diphosphate fluoroadenosine hydratase: containing) a [cysteine desulfurase]- L-malate CoA 6-carboxytetrahydropterin D-ribityl)lumazine quinolinate thiamine diphosphate hydroxymethylpyrimidine phosphatase: purine-nucleoside CELLY_RS04305 nitronate glycerophosphodiester a 7,8-dihydrofolate synthase tRNA processing A/G-specific type I methionyl tRNA [scaffold protein- dephospho- kinase/ synthase: CELLY_RS02570 30S ribosomal monooxygenase: phosphodiesterase: a metal a metal : BshA: bshA CELLY_RS04540 phosphorylase: 3-methylbutanoyl- 4-imidazolone- 2-iminopropanoate adenine biotin--[acetyl-CoA- RS01010 (2Fe-2S)] complex carboxylating protein S12 CELLY_RS01070 endolytic pyruvate aminopeptidase: lysidine(34) cation cation dihydrofolate CELLY_RS06395 CoA kinase: phosphomethylpyrimidine di-trans,octa-cis CELLY_RS04065 6-carboxytetrahydropterin CoA 5-propanoate CELLY_RS02790 carboxylase] ligase: nicotinate- a polycistronic methylthiotransferase transglycosylase glycosylase: kinase: pyk map synthetase reductase: (S)-malyl N- CELLY_RS16475 kinase: CELLY_RS06280 -undecaprenyl 5-fluoro-5-deoxy-D- synthase: CELLY_RS06050 SAH nitronate glycerophosphoryl CELLY_RS02880 nucleotide tRNA precursor RimO: rimO MltG: mltG mutY type I methionyl TilS: tilS CELLY_RS09800 riboflavin acetyl-α-D- bifunctional 5-(2-hydroxyethyl) phosphate ribose 1-phosphate 6-carboxy-5,6,7,8- imidazolonepropionase: hutI monooxygenase: diester coenzyme A diphosphorylase: [+ 2 isozymes] aminopeptidase: a metal a metal a [co-chaperone]- glucosaminide pyridoxal 5'-phosphate biosynthesis I hydroxymethylpyrimidine -4-methylthiazole tetrahydropterin adenosylhomocysteinase: CELLY_RS05340 phosphodiesterase: RS09290 a tetrahydrofolate biotinyl-5'- 34 [scaffold protein- bifunctional bacillithiol nadC 3-methylcrotonyl- pyruvate a [ribosomal an apurinic site pyruvate map a lysidine cation cation kinase/ 7-carboxy-7- N-formimino- CELLY_RS05090 5'-deoxyadenosine an unsulfurated CELLY_RS04240 dGTP / biosynthesis D-erythrose met protein S12]-3- a mature GlcNAc-1,6- adenine within DNA adenylate in tRNA Ile2 (2Fe-2S)] complex NaMN phosphomethylpyrimidine Amine and Polyamine Biosynthesis deazaguanine CoA L-glutamate [sulfur carrier] [unspecified SSQ1 bis(guanylyl molybdopterin) FAD synthetase: 4-phosphate 5-fluoro-5-deoxy-D- a tRNA precursor a tRNA precursor methylsulfanyl- peptidoglycan anhMurNAc- deacetylase kinase: thiD synthase QueE: methylcrotonoyl- 3-oxopropanoate nitrite degradation (n) an N-terminal cofactor sulfurylation CELLY_RS08870 4-methyl-5-(2- formimidoylglutamase: L-homocysteine 89 γ a metal a metal chaperone: BshB1: bshB1 nicotinate-nucleotide ribulose 1-phosphate CELLY_RS11000 with a 5' with a 5' CoA carboxylase: L-aspartate products] sn-glycerol (meso-DAP L-Ala- -D-Glu- met glycyl-[protein] RS14450 phosphooxyethyl) putrescine CELLY_RS03830 3-phosphate ser containing) cation cation dnaK (S)-malyl α-D- adenylyltransferase: HMP-PP histamine extension and extension and a CELLY_RS13590 DAP-D-Ala a [chaperone-ATP]- adenosylcobalamin FMN thiazole 7-carboxy-7- formimidoylglutamase: L-arginine cys CELLY_RS08340 biosynthesis I a long 3' trailer short 3' extension L-glutamine salvage from cobalamin glucosaminide molybdopterin biosynthesis 4-phospho- biosynthesis deazaguanine 3-methylglutaconyl- [co-chaperone]- bifunctional ribonuclease hutG degradation degradation I bacillithiol nicotinate adenine D-erythronate thiamine CoA 6-O-α-mycolyl- [scaffold protein- cysteine riboflavin kinase/ arg fluoroacetaldehyde P protein III (arginine a 5,10- a 2-thiouridine 34 phosphoenol a protein-L- L-fucose RS11090 L-fucose cob(I)alamin biosynthesis dinucleotide his glu L-threonine glycerophosphoglycerol 2-oxoglutarate isochorismate a nucleoside trehalose 6- (2Fe-2S)] complex desulfurase: FAD synthetase: phosphate component: decarboxylase/ methylenetetrahydrofolate in tRNA RNA pyruvate a mercapturate methionine- cysteine- cys histidine degradation II gln dGTP triphosphate dADP phosphate CELLY_RS00120 CELLY_RS08870 synthase: a tRNA rnpA agmatinase pathway) (R)-S-oxide adding decarboxylase: preQ arg imidazole bifunctional peptide- SSQ1 (3R)-3-hydroxy-2-oxo- CELLY_RS09390 0 precursor with a tRNA precursor cysteine cysteine ATP agmatine glycerol tRNA uridine-5- glycerophosphoryl alpha,alpha- methionine L-fucose RS02095 L-fucose chaperone cob(II)alamin FAD enzyme 4 phosphooxybutanoate thiamine CELLY_RS08830 a 5' extension with a short HMG-CoA thr 2-succinyl-5- DNA-directed desulfurase: + (R)-S-oxide ATPase: dnaK BshC: bshC desulfurase: NAD histamine phosphate carboxymethylaminomethyl(34) diester enolpyruvyl- trehalose- acylase: CELLY_RS07620 3-phosphoserine/ phosphate 3' extension RNA pyruvate cob(I)yrinic acid CELLY_RS00120 molybdopterin- agmatinase: fluoroacetate hydroxymethylglutaryl- L-alanine synthase: synthesis GTPase MnmE: mnmE dNTP phosphodiesterase: 6-hydroxy-3- phosphate CELLY_RS04415 reductase an [L-cysteine phosphohydroxythreonine synthase: thiE 4-fluorothreonine ribonuclease agmatine subunit omega: a [chaperone- a,c-diamide bacillithiol synthase GTP D-glyceraldehyde speB CoA lyase: hisF hisH triphosphohydrolase: dgt CELLY_RS04240 kinase: pyk synthase (UDP- MsrB: msrB cysteine menaquinol-6 biosynthesis P protein degradation IV L-2-amino-3- tRNA uridine-5- cyclohexene-1- CELLY_RS16510 2+ 2+ an [2Fe-2S] desulfurase]-S- transaminase: serC pyruvate CELLY_RS00590 forming)/trehalose- Cd RS16165 Cd ADP]-[disordered- adenosyltransferase: desulfurase: adenylyltransferase: 3-phosphate oxobutanoate agmatinase: [+ 8 isozymes] carboxymethylaminomethyl(34) glycerophosphodiester carboxylic-acid [+ 2 isozymes] cluster protein sulfanyl-L-cysteine 4-phosphooxy- putrescine component: [+ 2 isozymes] a [protein]-L- form scaffold CELLY_RS00200 CELLY_RS07620 CELLY_RS14095 GTP 3',8- thiamine phosphate speB glu synthesis enzyme MnmG: mnmG phosphodiesterase: synthase: menD phosphatase: acetate an L-cysteine- cysteine L-threonine demethylmenaquinol-6 rnpA acetoacetate ala methionine protein] complex cob(II)alamin- an [L-cysteine a carboxy-adenylated 1-deoxy-D-xylulose- glycine C- CELLY_RS02790 pyruvate CELLY_RS12785 S-conjugate desulfurase: cyclase alanine 2'-deoxyguanosine triphosphate dATP α, α'-trehalose non- [corrinoid bis(guanylyl desulfurase]-S- [small subunit of 4-hydroxythreonine- 5-phosphate thiamine- bifunctional acetyltransferase: kbl putrescine Cd 2+ RS14020 Cd 2+ CELLY_RS00120 MoaA: moaA an uncharged dehydrogenase: a 5-aminomethyl-2- 2-succinyl-5-enolpyruvoyl- RNA 6-α-mycolate chaperonin adenosyltranferase] molybdopterin) sulfanyl-L-cysteine molybdopterin synthase] (8S)-3',8-cyclo-7,8- 4-phosphate synthase: phosphate demethylmenaquinone a 7,8-dihydrofolate cysteine tRNA CELLY_RS11350 thiouridine 34 in tRNA 6-hydroxy-3-cyclohexene- molecular cofactor dihydroguanosine dehydrogenase CELLY_RS08295 kinase: thiL methyltransferase/2- gly glycerol sn-glycerol desulfurase: [+ 3 isozymes] 1-carboxylate chaperone molybdopterin 5'-triphosphate PdxA: pdxA methoxy-6-polyprenyl- 3-phosphate CELLY_RS07620 L-glutamine pyruvate L-asparagine alginate RS10300 alginate ATPase: dnaK synthase cyclic pyranopterin 3-amino-1- 1-deoxy-D- thiamine diphosphate 1,4-benzoquinol cob(I)alamin- a [bis(guanylyl degradation II degradation I an [Fe-S cluster sulfurtransferase: monophosphate hydroxyacetone xylulose 5- methylase UbiE: ubiE [corrinoid 4 β molybdopterin) [bis-MGD CELLY_RS14095 1-phosphate menaquinol-6 UDP-N-acetyl-α-D-muramoyl- a [DNA]-3'- a 5'-phospho- sn-glycero-3- a Xaa-Pro N -( -N-acetyl- 6-O-cis-keto- biosynthesis synthase phosphate lipoprotein posttranslational di-trans,octa-cis- NAD + O-phospho- adenosyltranferase] cofactor cofactor gln L-alanyl-γ-D-glutamyl-L- dipeptidyl- D-glucosaminyl) mycolyl-trehalose cys L-kynurenine chaperone]-ATP MoaC: moaC modification asn undecaprenyl phosphate hydroxyl [DNA] phosphoethanolamine L-homoserine dGDP alginate RS03695 alginate cob(I)yrinic acid chaperone]-S- chaperone]- a thiocarboxylated glutamate lysyl-D-alanyl-D-alanine peptidase -L-asparagine 6-phosphate pyridoxine 5'- asparaginase: bifunctional ribonucleoside- a,c-diamide sulfanyl-L-cysteine bis-MGD [small subunit of cyclic pyranopterin folate transformations III (E. coli) a [prolipoprotein]- synthase large phosphate NAD- alpha,alpha- adenosyltransferase: molybdopterin synthase] phosphate L-cysteine subunit: gltB CELLY_RS09155 glycerophosphodiester diphosphate synthase: phospho-N- N(4)-(beta-N- trehalose- cystathionine CELLY_RS00200 prolipoprotein glu asp dependent phosphodiesterase: kynureninase: reductase: Ca 2+ RS15745 Ca 2+ adenosylcob(III) CELLY_RS09755 a tetrahydrofolate Alcohol Degradation acetylmuramoyl- Xaa-Pro dipeptidyl- acetylglucosaminyl) gamma-synthase: biotin biosynthesis from molybdopterin diacylglyceryl DNA ligase CELLY_RS02790 phosphate kynU CELLY_RS08400 alamin-[corrinoid pentapeptide- peptidase: -L-asparaginase: synthase (UDP- CELLY_RS05370 8-amino-7-oxononanoate I sulfo-bis(guanylyl molybdenum synthase: transferase: lgt LigA: ligA glycerophosphoryl CELLY_RS08405 adenosyltranferase] pyridoxine glycerol and glycerophosphodiester degradation transferase: CELLY_RS13480 CELLY_RS09260 forming)/trehalose- molybdopterin) cofactor biosynthesis CELLY_RS07925 a [prolipoprotein]- diester GDP (8S)-8-amino-7- S-adenosyl-L-methionine salvage II methionine CELLY_RS10145 2+ 2+ cob(I)yrinic acid dipyrromethane 5'-phosphate phosphatase: anthranilate Ca RS12035 Ca oxononanoate cofactor synthase: metH S-1,2-diacyl-sn- phosphodiesterase: ala adenosylmethionine- a,c-diamide cofactor biosynthesis pyridoxamine a glycerophosphodiester [DNA] NMN a dipeptide with N-acetyl-β- CELLY_RS12785 L-cystathionine molybdate glyceryl-L-cysteine Fatty Acid and glycerol AMP CELLY_RS04240 trehalose-cis-keto- -8-amino-7- adenosyltransferase: molybdopterin 5'-phosphate dihydrofolate undecaprenyl-diphospho-N- UMP a C-terminal a peptide asp glucosaminylamine an apo-[hydroxymethylbilane SAH Lipid Degradation mono-mycolate oxononanoate CELLY_RS00200 molybdate oxidase: pdxH reductase: lipoprotein acetylmuramoyl-L-alanyl-γ-D- L-proline Mg 2+ Mg 2+ synthase]-L-cysteine RS03190 transaminase: bioA ABC adenosylhomocysteinase: CELLY_RS09800serine signal peptidase: oleate β-oxidation glycerophosphodiester glutamyl-L-lysyl- D-alanyl-D-alanine sn-glycerol Co 2+ Co 2+ (7R,8S)- adenosylcobalamin ethanolamine transporter CELLY_RS05090 PLP a 7,8-dihydrofolate hydroxymethyltransferase:a 5-methyltetrahydrofolate CELLY_RS05410 phosphodiesterase: 3-phosphate diaminononanoate molybdopterin a [hydroxymethylbilane substrate- L-homocysteine CELLY_RS13370 glycine cleavage system CELLY_RS02790 glycerol synthase] ES intermediate oleate dethiobiotin menaquinol-11 biosynthesis 2 aminomethyltransferase an (S-diacyl- 2+ Co 2+ binding thymidylate bifunctional 5,10- a lipoprotein glycerophosphoryl Co RS15830 UDP-N-acetyl-α-D- a 1-acyl-2- a peptide with 2+ 2+ synthase: bioD protein: hydroxymethylbilane 5-methyltetrahydropteroyltriglutamate- synthase: GcvT: gcvT a (6S)-5-formyltetrahydrofolate sn-glyceryl) signal peptide diester glycerol lipid II (meso Mg Mg all-trans- methylenetetrahydrofolate oleate--CoA ligase: di-trans,octa-cis- γ GGPP GGGP arachidonoyl- L-saccharopine a protein modA synthase: hemC - homocysteine S- [+ 2 isozymes] -L-cysteinyl- phosphodiesterase: kinase muramoyl-L-alanyl- -D- diaminopimelate ITP an N-terminal dADP undecaprenyl 1,4-dihydroxy- molybdopterin CELLY_RS09805 dehydrogenase/5,10-5-formyltetrahydrofolate CELLY_RS12820 undecaprenyl phosphate dethiobiotin menaquinol-10 biosynthesis methyltransferase: metE [apolipoprotein] glutamyl-L-lysyl-D-alanine containing) sn-glycerol ATP-dependent L-alanine 2-naphthoate a [hydroxymethylbilane methenyltetrahydrofolate CELLY_RS04240 GlpK: glpK nucleoside triphosphate ribonucleoside- diphosphate molybdate adenine folate polyglutamylation cyclo-ligase: 3-phosphate CTP synthase] ES intermediate methionine synthase: metH methylenetetrahydrofolate oleoyl-CoA Clp protease Mg 2+ RS08840 Mg 2+ biotin all-trans- dinucleotide 3 menaquinol-7 biosynthesis cyclohydrolase: CELLY_RS05415 pyrophosphohydrolase: diphosphate reductase [NAD(P)H]: metF phospho-N- geranylgeranylglycerol- peptidoglycan alanine proteolytic subunit: synthase decaprenyl 1,4-dihydroxy- hydroxymethylbilane CELLY_RS10975 a peptide sn-glycerol mazG peptidase M1: reductase: all-trans- met a tetrahydrofolate acyl-CoA acetylmuramoyl- phosphate synthetase: phosphatidate dehydrogenase: CELLY_RS03000 BioB: bioB diphosphate 2-naphthoate molybdopterin a 5,10-methylenetetrahydrofolate a 5,10-methenyltetrahydrofolate an N-acyl-(S- 3-phosphate CELLY_RS04315 CELLY_RS08400 synthase: hemC dehydrogenase: pentapeptide- geranylgeranyltransferase: CELLY_RS10660 cytidylyltransferase: CELLY_RS11350 nucleotide molybdotransferase heptaprenyl 1,4-dihydroxy- diacyl-sn-glyceryl) ATP-dependent Clp CELLY_RS08405 methionine CELLY_RS04215 pyrophosphohydrolase: + RS09845 Na + 9-mercaptodethiobiotin DMKH2-11 a [hydroxymethylbilane diphosphate 2-naphthoate bifunctional 5,10- -L-cysteinyl- CELLY_RS10235 transferase: penicillin-binding CELLY_RS02900 protease ATP-binding Na MoeA: adenosyltransferase: bifunctional serine CELLY_RS10010 ADP synthase] ES intermediate hydroxymethyltransferase: methylenetetrahydrofolate [lipoprotein] (2E,9Z)- CELLY_RS10145 protein 2: subunit ClpX: clpX biotin CELLY_RS14100 4 CELLY_RS09865 folylpolyglutamate IMP ala a peptide bifunctional CELLY_RS13370 dehydrogenase/5,10- octadecenoyl-CoA 2,3-bis-O- CELLY_RS03925 a CDP-1-acyl- 2-oxoglutarate lys synthase hydroxymethylbilane synthase/ an N 10 - DHAP a peptide demethylmenaquinone demethylmenaquinol- periplasmic disulfide bond formation undecaprenyl-diphospho-N (geranylgeranyl)-sn- 2-arachidonoyl- + + DMKH2-10 MoO - synthase: hemC SAM dihydrofolate methenyltetrahydrofolate UMP Na RS09810 Na BioB: bioB methyltransferase/2- 2 formyltetrahydrofolate 8 biosynthesis I -acetylmuramoyl-L-alanyl-γ- glycerol 1-phosphate glycerol molybdopterin synthase: a 5,10- cyclohydrolase: lipid II (meso di-trans,octa-cis bifunctional methoxy-6-polyprenyl- a holo-[hydroxymethylbilane demethylmenaquinol-7 bifunctional all-trans- a [DsbB protein] a [DsbA protein] two reduced D-glutamyl-L-lysyl- D-alanine biotin cofactor CELLY_RS10265 methylenetetrahydrofolate CELLY_RS10975 an electron- diaminopimelate -undecaprenyl demethylmenaquinone 1,4-benzoquinol synthase] folylpolyglutamate 1,4-dihydroxy- octaprenyl with reduced L- carrying a cysteine residues (S)-3-hydroxy-(9Z) bifunctional 10 transfer quinone containing) diphosphate methyltransferase/2- methylase UbiE: ubiE bifunctional synthase/ 2-naphthoate diphosphate an N -formyltetrahydrofolate cysteine residues disulfide bond in a protein -octadecenoyl-CoA NADH:ubiquinone demethylmenaquinone Secondary Metabolite Degradation methoxy-6-polyprenyl- a tetrahydrofolate folylpolyglutamate dihydrofolate 3-hydroxyacyl-CoA Na + reductase (Na(+) Na + menaquinol-11 methyltransferase/2- synthase/ an N 6 -L- UDP-N-acetylmuramoyl- a [lipoyl-carrier 1,4-benzoquinol synthase: 1,4-dihydroxy- dehydrogenase: 37 a dipetide with an N- -transporting) menaquinol-8 biosynthesis a sulfurated 37 3-methylbutanoate an adenosine a D-tyrosyl- a D-aspartyl- acetyl-CoA methoxy-6-polyprenyl- dihydrofolate anhydromuropeptides recycling I threonylcarbamoyladenine L-alanyl-γ-D- DMAPP protein]-N 6 -[(R) methylase UbiE: ubiE menaquinol-9 biosynthesis CELLY_RS10265 2-naphthoate CELLY_RS12810 [tRNA Tyr ] [tRNA asp ] terminal L-aspartate 1,4-benzoquinol synthase: [sulfur carrier] in tRNA in tRNA acetyl-CoA 10 octaprenyltransferase: glutamyl-meso-2,6- -dihydrolipoyl]- an N - 3-oxo-(9Z)- GlcNAc-1,6- sulfite menaquinol-10 demethylmenaquinol-8 methylase UbiE: ubiE CELLY_RS10265 diaminopimeloyl- L-lysine dihydrolipoyl carboxylase sulfite RS10335 demethylmenaquinol-9 formyltetrahydrofolate menA octadecenoyl-CoA anhMurNAc- acetate- bifunctional a 5,10- D-alanine tRNA (adenosine(37)-N6) D-tyrosyl-tRNA(Tyr) D-tyrosyl-tRNA(Tyr) dipeptidase dehydrogenase: biotin menaquinol-7 DsbA family acetyl-CoA C- L-Ala-γ-D-Glu- tRNA (N(6)-L- -CoA demethylmenaquinone bifunctional methylenetetrahydrofolate -dimethylallyltransferase deacylase: deacylase: PepE: pepE lpdA carboxylase : acyltransferase: DAP-D-Ala threonylcarbamoyladenosine(37) ligase: acs methyltransferase/2- demethylmenaquinone demethylmenaquinol-8 MiaA: miaA subunit: accC CELLY_RS12805 -C(2))- methylthiotransferase LD- CELLY_RS09995 CELLY_RS09995 dihydrolipoyl sulfite RS15270 sulfite methoxy-6-polyprenyl- methyltransferase/2- CELLY_RS01880 MtaB: mtaB carboxypeptidase: dehydrogenase: [+ 4 isozymes] methoxy-6-polyprenyl- DsbA family acetyl-CoA C- 1,4-benzoquinol 3-methylbutanoyl- 6 a proteinogenic a [lipoyl-carrier Tetrapyrrole Biosynthesis CELLY_RS01130 N -(3-methylbut- asp lpdA malonyl-CoA 1,4-benzoquinol oxidoreductase: acyltransferase: diphosphate 6 methylase UbiE: ubiE AMP CoA Tyr asp amino acid protein]-N -[(R N-acetyl-β-D- L-alanyl-γ-D- a 2-methylsulfanyl-N 6 -L- 2-en-1-yl)- D-tyrosine a tRNA tRNA D-aspartate menaquinol-8 methylase UbiE: ubiE CELLY_RS08060 CELLY_RS12165 37 sulfite RS06410 sulfite 37 an unsulfurated adenosine )-lipoyl]-L-lysine tetrapyrrole biosynthesis glucosamine-1,6- glutamyl-meso-2,6- threonylcarbamoyladenine 5'-deoxyadenosine met UDP-N-acetyl-α-D- menaquinol-9 superpathway of heme b biosynthesis from uroporphyrinogen-III heme b biosynthesis [sulfur carrier] I (from glutamate) siroheme biosynthesis (7Z)-hexadecenoyl-CoA anhydro-N-acetyl- diaminopimeloyl- in tRNA D-ala muramoyl-L-alanyl- in tRNA I (aerobic) Fatty Acid and Lipid Biosynthesis β-D-muramate D-alanine γ-D-glutamyl-meso- acyl-CoA uroporphyrinogen-III uroporphyrinogen-III glcNAc-1,6- LD- 2,6-diaminopimelate D-xylose RS15525 D-xylose glu uroporphyrinogen-III dehydrogenase: glutamate-- uroporphyrinogen-III C- a [DsbB protein] a [DsbA protein] anhMurNAcaminidase: carboxypeptidase: palmitate biosynthesis (type II fatty acid synthase) an electron- an intra- CELLY_RS10235 peptidoglycan biosynthesis I (meso-diaminopimelate containing) Cell Structure Biosynthesis uroporphyrinogen uroporphyrinogen carrying a with reduced L- CELLY_RS01130 fatty acid elongation -- saturated tRNA ligase: methyltransferase: cobA CELLY_RS01185 N 6 -(3-methylbut- lipid IV biosynthesis (E. coli) decarboxylase: hemE decarboxylase: hemE transfer quinol protein disulfide (2E,7Z)- L-alanyl-γ-D- an (S)-2- a 2-oxo (2R,3S)-3- D-sedoheptulose A CELLY_RS06670 disulfide bond cysteine residues 1,6-anhydro-N- 2-methylbutanoate Ala a reduced UDP-N-acetyl- uroporphyrinogen-III C- glutamyl-meso- a sulfurated [sulfur carrier] 2-en-1-yl)- halocarboxylate carboxylate L-ornithine a glycyl-[tRNA ] isopropylmalate 1,7-bisphosphate Glu coproporphyrinogen III hexadecenoyl-CoA dGTP AMP H O c-type an acetoacetyl-[acp] an L-glutamyl-[tRNA ] acetyl-β-muramate 37 2 α-D-glucosamine a (3R)-3- methyltransferase: cobA coproporphyrinogen III diaminopimelate adenosine in tRNA 3-isopropylmalate cytochrome an acetoacetyl-[acp] nucleoside triphosphate cytochrome hydroxytetradecanoyl- UDP-N-acetyl- precorrin-1 oxygen-dependent anhydro-N- dehydrogenase: 5'/3'- c oxidase an oxidized 3-oxoacyl-[acyl- UDP-N-acetylglucosamine acetate- haloacid pyrophosphohydrolase: class II fructose- [acp] α glutamyl-tRNA coproporphyrinogen acetylmuramic ornithine- leuB O c-type 1-carboxyvinyltransferase: -D-glucosamine tRNA (N6-isopentenyl D-tyrosyl-tRNA(Tyr) nucleotidase 2 carrier-protein] uroporphyrinogen-III C- oxygen-dependent oxygen-independent 5-oxo-L-proline metabolism -CoA dehalogenase mazG bisphosphate a reduced murA reductase: hemA oxidase: hemF (S)-3-hydroxy-(7Z) acid kinase: -oxo-acid deacylase: 3-isopropylmalate SurE: surE cytochrome reductase: fabG methyltransferase: cobA coproporphyrinogen coproporphyrinogen adenosine(37)-C2)- ligase: acs type II: aldolase: fbaA H O c-type acyl-ACP--UDP-N- NADH repair (prokaryotes) CELLY_RS01190 transaminase: nucleotide 2 cbb3-type UDP-N-acetyl-α- a [protein] with -hexadecenoyl-CoA D-galacturonate degradation I methylthiotransferase CELLY_RS09995 dehydrogenase: 3-ketoacyl-ACP acetylglucosamine O- (S)-4-amino-5-oxopentanoate uroporphyrinogen-III C- oxidase: hemF III oxidase: hemN protoporphyrinogen IX N-acetyl-D- CELLY_RS01890 rocD pyrophosphohydrolase: leuB adenosine cytochrome cytochrome D-glucosamine- an N-terminal 3-hydroxyacyl-CoA MiaB: miaB (2S)-2- an oxidized reductase: a 3-oxoacyl-[acp] acyltransferase: lpxA methyltransferase: cobA muramate 6- HAD family CELLY_RS10010 4-methyl-2- D-erythrose c oxidase enolpyruvate glutamate-1- protoporphyrinogen NADH a [protein] with dehydrogenase: aldehydo-D- DHAP O c-type CELLY_RS07230 L-glutamine methylbutanoyl- diphosphate oxopentanoate 4-phosphate 2 phosphate galacturonate AMP hydrolase: Ala dGMP a reduced semialdehyde 2,1- precorrin-2 protoporphyrinogen IX protoporphyrinogen IX oxidase: an N-terminal CELLY_RS12810 N 6 -(3-methylbut-2-en- a proteinogenic L-glutamate-5- a tRNA gly cytochrome 3-ketoacyl-ACP UDP-N- UDP-3-O-[(3R)-3- N-acetylmuramic CoA CELLY_RS12980 H O c-type a (3R)-3- aminomutase: hemL CELLY_RS07745 glutaminyl-peptide L-glutamate 3-oxo-(7Z)- 5'-deoxyadenosine 1-yl)-2-(methylsulfanyl) an unsulfurated amino acid semialdehyde 2 reductase: acetylmuramate hydroxymyristoyl]-N- met hydroxybutanoyl-[acp] bifunctional precorrin- acid 6-phosphate 37 [sulfur carrier] RS10310 cytochrome dehydrogenase: α protoporphyrinogen cyclotransferase: hexadecenoyl-CoA adenosine in tRNA an oxidized beta-ketoacyl CELLY_RS07230 acetyl- -D-glucosamine 5-aminolevulinate 2 dehydrogenase/ protoporphyrin IX etherase: murB oxidase: CELLY_RS07745 CELLY_RS13405 acetyl-CoA C- a (2R)-2- O c-type bifunctional synthase: 3-oxoacyl-[acyl- bifunctional sirohydrochlorin CELLY_RS03755 D-tagaturonate a halide anion 2 ala UDP-N-acetyl- (R)-NADHX acyltransferase: hydroxy fatty acid cytochrome UDP-3-O-[3- CELLY_RS05195 carrier-protein] UDP-3-O-[3- porphobilinogen ferrochelatase: ferrochelatase: a [protein] with N-acetylmuramic hydroxymyristoyl] N- α-D-muramate hydroxymyristoyl] N- bifunctional γ-L-glutamyl CELLY_RS12805 tagaturonate beta-ketoacyl- reductase: fabG synthase: hemB CELLY_RS09920 protoporphyrin IX hemH an N-terminal 5- acid 6- acetylglucosamine acetylglucosamine ADP-dependent 5-phosphate glutathione acetyl-CoA C- reductase: a nascent peptidoglycan a peptidoglycan ACP synthase oxo-L-proline phosphate dihomo γ- a [protein]-L- D-sedoheptulose deacetylase/3- a 2,3,4-saturated a (3R)-3-hydroxyacyl- UDP-N- deacetylase/3- porphobilinogen sirohydrochlorin protoheme NAD(P)H-hydrate acyltransferase: CELLY_RS02110 DL-allothreonine glu a (6S)-5- H O etherase: murQ (meso-DAP containing) dimer (generic) linolenoyl-CoA 2 β-isoaspartate 1-phosphate IMP II: fabF bifunctional acetylmuramate-- ferrochelatase: hemH dehydratase/ formyltetrahydrofolate dATP hydroxyacyl-ACP fatty acyl-[acp] [acyl-carrier protein] hydroxyacyl-ACP CELLY_RS12165 N-acetyl-D- D-altronate protein-L- dehydratase: UDP-3-O-[3- glu L-alanine ligase: dehydratase: hydroxymethylbilane bifunctional precorrin- NAD(P)H-hydrate nucleoside triphosphate isoaspartate(D- glucosamine endolytic endolytic class II fructose- 5'/3'- CELLY_RS14910 hydroxymyristoyl] N- CELLY_RS10165 CELLY_RS14910 synthase: hemC 2 dehydrogenase/ protoheme epimerase: (5Z)-tetradecenoyl-CoA altronate acyl-CoA pyrophosphohydrolase: aspartate) O- 6-phosphate transglycosylase serine bifunctional transglycosylase bisphosphate nucleotidase acetylglucosamine glutamate peptidoglycan UDP-3-O-(3- sirohydrochlorin CELLY_RS12135 5-oxo-L-proline dehydratase: thioesterase: mazG methyltransferase: (S)-NADHX acyl-CoA MltG: mltG hydroxymethyltransferase: folylpolyglutamate MltG: mltG aldolase: fbaA SurE: surE a (2E)-but-2-enoyl-[acp] deacetylase/3- racemase: synthetase: hydroxymyristoyl) preuroporphyrinogen ferrochelatase: CELLY_RS02115 CELLY_RS16565 nucleotide CELLY_RS13325 dehydrogenase: CELLY_RS13370 synthase/ a protein L-β- hydroxyacyl-ACP murI α CELLY_RS09920 5-oxoprolinase: [+ 2 isozymes] [+ 2 isozymes] [+ 5 isozymes] pyrophosphohydrolase: CELLY_RS10660 lipid IV biosynthesis (P. putida) - -D-glucosamine uroporphyrinogen- bifunctional CELLY_RS10235 2-dehydro-3- dihydrofolate inosine dehydratase: A D-glucosamine isoaspartate UDP-3-O-(3- ADP-dependent pxpB pxpA CELLY_RS10010 D-erythrose D-glt UDP-N-acetyl-α-D- III synthase: siroheme (2E,5Z)- deoxy-D-gluconate a mature peptidoglycan a nascent peptidoglycan synthase: GlcNAc-1,6- α-methyl ester DHAP CELLY_RS14910 a (3R)-3- hydroxymyristoyl) NAD(P)H-hydrate 6-phosphate acetaldehyde a lipid II di-homo-γ- dAMP muramoyl-L-alanine CELLY_RS04960 tetradecenoyl-CoA 2-dehydro-3- with (L-alanyl-γ-D-glutamyl- (meso-DAP containing) gly CELLY_RS10265 anhydro-MurNAc- a 2,3,4-saturated a trans-2-enoyl- hydroxydecanoyl- UDP-N-acetyl- glucosamine N- dehydratase/ glu phosphoglucosamine linolenate deoxygluconokinase: meso-2,6-diaminopimeloyl- with GlcNAc terminus pentapeptide [acp] α-D-glucosamine acyltransferase: uroporphyrinogen-III a butanoyl-[acp] fatty acyl-[acp] [acyl-carrier protein] NAD(P)H-hydrate ∆ 3 ∆ 2 mutase: glmM UDP-N- lpxD -cis- -trans- CELLY_RS11875 D-alanine) tetrapeptide a (6S)-5- epimerase: α-D-glucosamine acetylmuramoyl- acyl-ACP--UDP-N- enoyl-CoA formyltetrahydrofolate beta-ketoacyl- [+ 2 isozymes] CELLY_RS12135 1-phosphate KDGP L-alanine-- acetylglucosamine O- UDP-2-N,3-O-bis[(3R)- isomerase: (S)-3-hydroxy-(5Z) ACP synthase D-glutamate CELLY_RS12810 acyltransferase: lpxA 3-hydroxytetradecanoyl]- NADH N 6 -L-threonylcarbamoyladenosine 37 -tetradecenoyl-CoA II: fabF 4 an unstable ligase: murD α a [protein]- an O - a 2'- a long-chain (S)-1-pyrroline- fatty acid biosynthesis -D-glucosamine -modified tRNA biosynthesis 3-hydroxyacyl-CoA bifunctional palmitoyl-CoA a D-aminoacyl- H O DHAP beta-ketoacyl phosphatidylserine and a ferrocytochrome b methylthymine deoxyribonucleoside 2 RecA filament- UDP-3-O-[(3R)-3- (3E,5Z)-tetradeca- 5 L-cysteine [DNA] fatty acyl-CoA 5-carboxylate initiation (type II) UDP-2,3- dehydrogenase: N-acetyl-α-D- 4-hydroxy-2- [tRNA] GTP synthase: phosphatidylethanolamine UDP-N-acetyl- hydroxydecanoyl]- 3,5-dienoyl-CoA in DNA 5'-triphosphate NAD(P)H- L-glutamate DNA complexDNA α diacylglucosamine CELLY_RS12810 glucosamine oxoglutarate nucleoside triphosphate CELLY_RS05195 biosynthesis I meso-diaminopimelate -D-muramoyl-L- N-acetyl-α-D- thr dependent glycerol- gamma- repair acetyl-CoA diphosphatase: acyl-CoA 3-oxo-(5Z)- 1-phosphate aldolase/2- acyl-CoA alanyl-D-glutamate glucosamine peptidoglycan maturation (meso-diaminopimelate containing) threonylcarbamoyl- methylated-DNA-- D-tyrosyl-tRNA(Tyr) pyrophosphohydrolase: 3-phosphate semialdehyde acetyl-CoA a CDP-diacylglycerol CELLY_RS06045 thioesterase: acyl-CoA desaturase: translesion error- thioesterase: protein a 3-oxohexanoyl-[acp] AMP synthase: tetradecenoyl-CoA dehydro-3-deoxy- [protein]-cysteine S- deacylase: mazG dehydrogenase: dehydrogenase: carboxylase bifunctional lipid II (meso CELLY_RS16565 CELLY_RS03205 prone DNA CELLY_RS14770 RecO: UDP-N- UDP-2,3- CELLY_RS00405 acetyl-CoA C- phosphogluconate methyltransferase: CELLY_RS09995 nucleotide CELLY_RS05560 pruA carboxyltransferase UDP-3-O-[3- diaminopimelate containing) [+ 5 isozymes] acyl-CoA desaturase: polymerase V a stabilizedrecO 3-oxoacyl-[acyl- a 3-sn-phosphatidyl- acetylmuramoyl- diacylglucosamine threonylcarbamoyl- acyltransferase: UDP-N-acetyl- aldolase: CELLY_RS07870 [+ 5 isozymes] pyrophosphohydrolase: sn-glycerol subunit beta: hydroxymyristoyl] N- penicillin-binding (3E,5Z)- α CELLY_RS14550 autoproteolytic glu RecA filament- carrier-protein] L-serine L-alanyl-D- diphosphatase: AMP synthase: CELLY_RS12165 -D-glucosamine CELLY_RS09050 CELLY_RS10010 3-phosphate CELLY_RS03275 acetylglucosamine protein 2: tetradecadienoate subunit: umuD DNA complex reductase: fabG glutamate--2, 6- CELLY_RS14185 CELLY_RS13945 acetyl-CoA C- UDP-N-acetylglucosamine a [protein]-S- an uncharged a long-chain GMP malonyl-CoA phosphatidylserine deacetylase/3- CELLY_RS03925 (L-threonylcarbamoyl) bifunctional a thymine in DNA [+ 6 isozymes] a D-amino acid 3-ketoacyl-ACP diaminopimelate acyltransferase: 1-carboxyvinyltransferase: methyl-L-cysteine tRNA fatty acid decarboxylase D-ala hydroxyacyl-ACP lipid X a nascent peptidoglycan adenylate 4-hydroxy-2- palmitoleoyl-CoA a ferricytochrome b reductase: ligase: CELLY_RS12805 murA 5 ACP S- family protein: dehydratase: γ oxoglutarate with (L-alanyl- -D-glutamyl- tRNA (adenosine(37)-N6)- UDP-N-acetyl-α- CELLY_RS07230 malonyltransferase: CELLY_RS02905 CELLY_RS10140 CELLY_RS14910 lipid-A- (3Z)-dodec- aldolase/2- [DNA] D-alanine--D- meso-2,6-diaminopimeloyl-D- threonylcarbamoyltransferase D-glucosamine- a (3R)-3- fabD an L-1- UDP-3-O-(3- disaccharide 3-enoyl-CoA dehydro-3-deoxy- alanine ligase: UDP-N-acetyl-α-D- alanyl-D-alanine) pentapeptide complex dimerization enolpyruvate hydroxyhexanoyl-[acp] hydroxydecanoyl) synthase: lpxB ∆3,∆2-enoyl- phosphogluconate phosphatidylethanolamine CELLY_RS02850 muramoyl-L-alanyl- subunit type 1 TsaB: tsaB a malonyl-[acp] -α-D-glucosamine lipid A disaccharide UDP-N- 38- γ penicillin-binding CoA isomerase: aldolase: a [2-oxoglutarate- a 2'- a [protein] N- D-firefly a uridine a [protein]- bifunctional D-alanyl-D-alanine -D-glutamyl-meso- UDP-3-O-(3- (E. coli) [+ 2 isozymes] acetylmuramate a sulfurated H + hydrogencarbonate a D-tryptophanyl- H O protein 2: 6 CELLY_RS12810 CELLY_RS11880 SAM dehydrogenase deoxyribonucleoside Trp terminal-formyl- 2 a protein UDP-3-O-[3- 2,6-diaminopimelate an N -L- [DNA] [tRNA ] luciferyl-CoA 40 in tRNA L-tyrosine ketoacyl-ACP hydroxymyristoyl) dehydrogenase: [sulfur carrier] 6 5'-triphosphate L-methionine RluA family polysaccharide tetraacyldisaccharide a nascent peptidoglycan CELLY_RS03925 a mature peptidoglycan with threonylcarbamoyladenine 37 (2E)-dodec- E2 protein] N - membrane hydroxymyristoyl] N- synthase III: glucosamine N- murB pseudouridine biosynthesis UDP-N- 4'-kinase: lpxK with (L-alanyl-γ-D-glutamyl- (L-alanyl-γ-D-glutamyl-meso- in tRNA 2-enoyl-CoA D-glyceraldehyde octanoyl-L-lysine metalloprotease: acetylglucosamine CELLY_RS02470 acyltransferase: a nascent peptidoglycan UDP-N-acetyl- pyruvate carbonic anhydrase: acyl-CoA synthase: tyrosine acetylmuramoyl- meso-2,6-diaminopimeloyl- 2,6-diaminopimeloyl-D-alanyl- 3-phosphate DNA polymerase D-tyrosyl-tRNA(Tyr) peptide CELLY_RS15785 deacetylase/3- [+ 2 isozymes] lpxD lipid IV (E. coli) α-D-muramate lipoyl CELLY_RS05785 thioesterase: A D-alanine) tetrapeptide with D,D cross-links (meso- D-alanine) pentapeptide III subunit delta': deacylase: deformylase: CELLY_RS02840 autokinase: hydroxyacyl-ACP tripeptide--D-alanyl- NADPH repair (prokaryotes) carbonic anhydrase: CELLY_RS16565 [+ 5 isozymes] [+ 2 isozymes] diaminopimelate containing) synthase: CELLY_RS06740 CELLY_RS09995 CELLY_RS00365 [+ 4 isozymes] CELLY_RS13310 D- alanine ligase: 38- a [protein]- dehydratase: an acetoacetyl-[acp] UDP-2-N-[(3R)-3- (S)-3- lipA CELLY_RS06055 [+ 5 isozymes] a pseudouridine a peptide CELLY_RS10395 LD-carboxypeptidase: [+ 7 isozymes] L-tyrosine CELLY_RS14910 hydroxydodecanoyl]- NADPH hydroxydodecanoyl-CoA 40 in tRNA CELLY_RS01130 Glycolysis UDP-N-acetyl- phosphate 3-O-[(3R)-3- a [2-oxoglutarate an N-terminal L- α a nascent peptidoglycan a nascent peptidoglycan a mature peptidoglycan an unsulfurated Trp formate a (2E)-hex-2-enoyl-[acp] acyl-CoA hydrolysis UDP-N-acetyl- -D- a mature peptidoglycan 3-hydroxyacyl-CoA α-D-muramoyl- 5'-deoxyadenosine met dehydrogenase CO H O D-tryptophan a tRNA methionyl-[protein] D-firefly luciferin hydroxydecanoyl]- a nascent peptidoglycan with γ γ 2 2 with L,D cross links (meso- with (L-alanyl- -D-glutamyl- with (L-alanyl- -D-glutamyl- with D,D cross-links (meso- dehydrogenase/ γ 6 [sulfur carrier] [DNA] muramoyl-L-alanyl- α (L-alanyl-γ-D-glutamyl-meso- L-alanyl- -D- E2 protein] N -D-glucosamine meso-2,6-diaminopimeloyl- glycolysis I (from glucose 6-phosphate) a 2,3,4-saturated γ-D-glutamyl-meso- diaminopimelate containing) meso-2,6-diaminopimeloyl- diaminopimelate containing) enoyl-CoA glutamyl-meso-2,6- -lipoyl-L-lysine di-trans,octa-cis- UDP-2,3- 2,6-diaminopimelate) tripeptide fatty acyl CoA 2,6-diaminopimeloyl- glycine) tetrapeptide D-alanine) tetrapeptide hydratase diaminopimelate acyl-CoA undecaprenyl phosphate diacylglucosamine D-alanyl-D-alanine D-glucopyranose 6-phosphate (R)-NADPHX family protein: thioesterase: bifunctional GDP-α-D- trans,octacis an O 6 - 5-fluorouridine 5'- diphosphatase: CELLY_RS12810 a [protein]- a [DNA]-3'- O-succinyl-L- α-Kdo CELLY_RS14770 a mature peptidoglycan ADP-dependent -decaprenyl CTP an acyl-CoA H O monophosphate a hexanoyl-[acp] CELLY_RS06045 mannose L-cysteine methylguanine 2 Hyp a protein phospho-N- with L,D cross-links (meso- a mature peptidoglycan with a mature peptidoglycan glucose-6-phosphate hydroxyl homoserine noncanonical [+ 5 isozymes] γ NAD(P)H-hydrate 3-oxododecanoyl-CoA phosphate in DNA a 2,3,4-saturated acetylmuramoyl- UDP-2,3- diaminopimelate containing) (L-alanyl- -D-glutamyl-meso- γ pyrimidine 4-hydroxyproline beta-ketoacyl- with (L-alanyl- -D-glutamyl- isomerase: pgi dehydratase/ fatty acid pentapeptide- diacylglucosamine 2,6-diaminopimelate) tripeptide 3-deoxy-manno- endopeptidase meso-2,6-diaminopimeloyl- NAD(P)H-hydrate acetyl-CoA C- polyprenol methylated-DNA-- exodeoxyribonuclease acyl-CoA nucleotidase, epimerase: ACP synthase transferase: diphosphatase: cystathionine octulosonate La: lon glycine) tetrapeptide gluconeogenesis I Carbohydrate Biosynthesis α epimerase: acyltransferase: monophosphomannose [protein]-cysteine S- III: xth thioesterase: YjjG family: CELLY_RS16215 II: fabF CELLY_RS10145 CELLY_RS14185 UDP-N-acetyl-D- UDP- -D- gamma-synthase: cytidylyltransferase: F6P CELLY_RS12135 CELLY_RS12805 synthase: methyltransferase: exodeoxyribonuclease CELLY_RS16565 CELLY_RS10690 (4R)-4-hydroxy- beta-ketoacyl glucosamine biosynthesis I galactose CELLY_RS05370 kdsB a peptide (S)-NADPHX CELLY_RS04970 III: xth [+ 5 isozymes] D-proline synthase: undecaprenyldiphospho- lipid X (P. putida) (S)-malate biosynthesis acetyl-CoA C- CELLY_RS07870 5-fluorouridine D-glucopyranose acyltransferase: CELLY_RS05195 N-acetylmuramoyl-L- 6-phosphate UDP-α-D-glucose class 1 fructose- 6-: bifunctional trans,octacis- lipid-A- CELLY_RS12165 a 2'- succinate alanyl-γ-D-glutamyl-meso glucose-6- UDP-glucose ADP-dependent decaprenylphospho- a [protein]-S- a [DNA]-3'- L-homocysteine CMP-Kdo disaccharide bisphosphatase: fbp pfkA GDP a guanine in DNA deoxyribonucleoside a carboxylate a 3-oxooctanoyl-[acp] -2,6-diaminopimeloyl- phosphate 4-epimerase NAD(P)H-hydrate β-D-mannose methyl-L-cysteine hydroxyl synthase: lpxB malate decanoyl-CoA 5'-monophosphate D-alanyl-D-alanine isomerase: pgi GalE: galE dehydratase/ 3-oxoacyl-[acyl- lipid A dehydrogenase: F6P β undecaprenyldiphospho- DHAP -D-fructose 1,6-bisphosphate NAD(P)H-hydrate acyl-CoA carrier-protein] disaccharide CELLY_RS11515 UDP-glucose muramoylpentapeptide beta-N- epimerase: dehydrogenase: (P. putida) glutamine-- 4-epimerase a uridine 34 a thiocarboxylated (1S,2R)-1- a double reductase: fabG acetylglucosaminyltransferase: class II fructose- CELLY_RS10235 a peptide with a a tripeptide carbonic acid malate fructose-6- GalE: galE CELLY_RS12135 cob(II)alamin [SAMP] C- ser C-(indol-3- stranded DNA his repressor LexA 3-ketoacyl-ACP murG tetraacyldisaccharide triose-phosphate bisphosphate ATP in tRNA leader sequence dehydrogenase: phosphate glycogen biosynthesis I (from ADP-D-Glucose) UDP-α-D-galactose terminal glycine yl)glycerol DNA gyrase/ reductase: lipid II (meso 4'-kinase: lpxK isomerase: aldolase: fbaA NADPH (2E)-dec-2-enoyl-CoA CELLY_RS09415 transaminase 3-phosphate topoisomerase L-histidine N(alpha) CELLY_RS07230 diaminopimelate lipid IV oxaloacetate CELLY_RS11685 carbonic anhydrase: repressor A (isomerizing) D-glucopyranose tRNA 2- peptidase IV subunit A: -methyltransferase: containing) (P. putida) cob(I)yrinic acid signal CELLY_RS05785 LexA: lexA a (3R)-3- pyruvate : glmS 6-phosphate thiouridine(34) tryptophan T: pepT CELLY_RS14990 CELLY_RS15730 a,c-diamide peptidase phosphoenolpyruvate phospho- synthase: trpB carbonic anhydrase: cleaved hydroxyoctanoyl-[acp] D-glucosamine α D-glyceraldehyde 3-phosphate synthase I: lepB [+ 2 isozymes] hercynine carboxykinase UDP- -D-glucuronate (S)-3- adenosyltransferase: CELLY_RS02785 CELLY_RS06055 a negatively 6-phosphate sugar mutase: MnmA: mnmA repressor LexA bifunctional (ATP): pckA biosynthesis (from hydroxydecanoyl-CoA CELLY_RS00200 supercoiled DNA CELLY_RS12890 type I glyceraldehyde- a proteinogenic a dipeptide UDP-3-O-[3- phosphoglucosamine α UDP-glucose) (S)-3- D-glyceraldehyde Nucleoside and Nucleotide Biosynthesis -D- 3-phosphate a [SAMP] C- a 2-thiouridine 34 amino acid hydroxymyristoyl] N- mutase: glmM UDP-α-D-glucose hydroxydecanoyl- adenosylcobalamin 3-phosphate trp a leader sequence a peptide CO H O phosphoenolpyruvate glucopyranose dehydrogenase: gap terminal glycine in tRNA 2 2 acetylglucosamine α-D-glucosamine UDP-glucose 6- CoA triphosphate superpathway of pyrimidine 1-phosphate deacetylase/3- superpathway of guanosine 1-phosphate dehydrogenase: [+ 2 isozymes] dehydrogenase: ribonucleotides de novo biosynthesis superpathway of purine deoxyribonucleosides salvage pyrimidine deoxyribonucleotides superpathway of pyrimidine phosphopyruvate hydroxyacyl-ACP nucleotides de novo biosynthesis I CELLY_RS06810 CELLY_RS12810 adenosine nucleotides de novo biosynthesis I nucleobases salvage hydratase: eno UDP-α-D- Metabolic Clusters dehydratase: de novo biosynthesis I 13-DPG a [protein]- a DNA methyl a 3-(acyloxy) a supercoiled UDP CTP a (1->4)- glucuronate methanethiol O-acetyl-L- O-succinyl-L- ammonium NAD + H O oleoyl-CoA H O roseoflavin an unfolded CELLY_RS14910 gln hydrogencarbonate uracil ADP-α-D-glucose 3-oxodecanoyl-CoA L-cysteine phosphotriester cys acyl group of 2 2 duplex DNA IMP 2'-deoxyguanosine 2'-deoxyadenosine ribonucleoside- 2-phospho-D-glycerate N-acetyl-α-D- α-D-glucan N-end rule pathway I (prokaryotic) homoserine homoserine bifunctional protein IMP bifunctional pyr operon bacterial toxin UvrD- asp deoxynucleoside deoxynucleoside diphosphate glucosamine glycogen/starch phosphoglycerate acetyl-CoA C- a (2E)-oct-2-enoyl-[acp] transcriptional regulator/uracil 2,3-bisphosphoglycerate- domain-containing riboflavin kinase/ chaperonin kinase: kinase: CDP synthase: kinase: leucyl/phenylalanyl- acyltransferase: methylated-DNA-- nitrite acyl-CoA carbamoyl- IMP reductase: phosphoribosyltransferase independent 1-phosphate O-acetylhomoserine protein: FAD synthetase: CELLY_RS06745 tRNA--protein cystathionine acyloxyacyl reductase: GroEL: groL phosphate dehydrogenase: CELLY_RS09850 CELLY_RS09850 CELLY_RS08400 ribonucleoside- PyrR: pyrR CELLY_RS05295 CELLY_RS12805 aminocarboxypropyltransferase/ [protein]-cysteine S- thioesterase: CELLY_RS06260 CELLY_RS08870 adenylosuccinate dGMP phosphoglycerate transferase: gamma-synthase: hydrolase: nirB nirD synthase guaB dAMP CELLY_RS08405 diphosphate UMP a (1->4)- acetyl-CoA C- cysteine synthase: methyltransferase: CELLY_RS14770 roseoflavin synthase: mutase: α CELLY_RS05015 a [protein] CELLY_RS05370 CELLY_RS09945 [+ 3 isozymes] a protein large dUDP reductase: UDP-N-acetyl- -D-glucan GDP-L-fucose 3-phospho-D-glycerate an N-terminal acyltransferase: CELLY_RS09870 CELLY_RS07870 [+ 5 isozymes] a single 5'-phosphate CELLY_RS01380 UMP kinase: CELLY_RS03115 N-terminal L- subunit: carB XMP CELLY_RS08400 α-D-glucosamine biosynthesis I (from arginyl-[protein] CELLY_RS12165 stranded DNA an octanoyl-[acp] nucleoside- CELLY_RS09220 leucyl-L-arginine a 3-hydroxyacyl nitrite CELLY_RS08405 3-phospho-D-glycerate GDP-D-mannose) glutamine- diphosphate CMP 2,3-bisphosphoglycerate- a [protein]-S- L-cystathionine succinate group of a fatty acid a sugar RS14490 a sugar UDP GDP-α-D-mannose octanoyl-CoA acetate met [DNA] oleate beta-ketoacyl- hydrolyzing glutamine- adenylo-succinate kinase: phosphorylation independent methyl-L-cysteine bacterial toxin dCDP phosphoglycerate a glycogen GDP-mannose leucyl/phenylalanyl- ACP synthase carbamoyl- hydrolyzing GMP CELLY_RS01305 nucleoside-diphosphate phosphoglycerate tRNA--protein acyl-CoA adenylosuccinate dGDP dADP nucleoside- CMP kinase: 4,6-dehydratase: II: fabF phosphate synthase: guaA kinase: CELLY_RS01305 mutase: transferase: dehydrogenase: lyase: purB dUTP diphosphate (d)CMP kinase: CELLY_RS06745 dTDP-β-L-rhamnose gmd GDP-4-dehydro- CELLY_RS03115 a [protein] CELLY_RS10235 2503 N-acetyl-D-glucosaminyl-N- an N-formyl-L- α-D- chloride RS08275 chloride beta-ketoacyl synthase nucleoside- nucleoside- UTP an N-terminal CELLY_RS05015 adenine (+)-7-epi- β-D-fructofuranose an N-acylated GMP dUTP kinase: CELLY_RS00885 biosynthesis α N-terminal L- H O -D-rhamnose acetylmuramoyl-L-alanyl-D-glutamyl- methionylaminoacyl- 2 aliphatic-L- glucosaminide- IPP synthase: small diphosphate diphosphate CTP synthase: CDP 13-DPG L-lysyl-[protein] in 23S rRNA jasmonoyl-CoA 1-phosphate ATP diphosphatase: CELLY_RS01305 α-D-glucopyranose leucyl-L-lysine (2E)-oct-2-enoyl-CoA tRNA [heparan sulfate] CELLY_RS05195 subunit: carA AMP kinase: kinase: GDP-L-fucose 2-phospho-D-glycerate 6-carboxy-L-lysyl-D-alanine amino acid heparan-alpha- isopentenyl- dut CELLY_RS01085 nucleoside- α dCTP type I 1-phosphate UDP-N-acetyl- -D- synthase: glucosaminide N- sulfate diphosphate guanylate CELLY_RS01305 CELLY_RS01305 glucose-1-phosphate 23S rRNA acyl-CoA class II fructose- a 3-oxodecanoyl-[acp] [+ 2 isozymes] CTP diphosphate mannosaminouronate CELLY_RS13190 peptide Delta- an anion RS03440 an anion carbamoyl kinase: gmk glyceraldehyde- thymidylyltransferase: (adenine(2503)-C(2) LD-carboxypeptidase: acetyltransferase: adenylyltransferase asp : kinase: biosynthesis phosphopyruvate thioesterase: bisphosphate acylase: phosphate dGTP dATP dUMP 3-phosphate GDP-4-dehydro-6- deformylase: N-acetyl-α-D-CELLY_RS06400 subunit CysD: cysD isomerase: idi CELLY_RS16910 CELLY_RS01305 CELLY_RS12910 UDP-N-acetyl- β hydratase: eno (S)-3- )-methyltransferase CELLY_RS01130 CELLY_RS16565 aldolase: fbaA CELLY_RS04415 3-oxoacyl-[acyl- dehydrogenase: deoxy- -L-galactose CELLY_RS00365 DMAPP thymidylate glucose-1-phosphate α-D-glucosamine RlmN: rlmN [+ 5 isozymes] glucosaminide- APS carrier-protein] GDP CTP triose-phosphate gap GDP-L-fucose hydroxyoctanoyl-CoA aspartate synthase: UDP-N- [heparan sulfate] reductase: fabG thymidylyltransferase 3-hydroxyacyl-CoA N-acetyl-D-glucosaminyl-N- sulfate RS07200 sulfate carbamoyltransferase ADP xanthine and isomerase: [+ 2 isozymes] acetylglucosamine synthase: DHAP D-glyceraldehyde CELLY_RS09805 RfbA: rfbA phosphoenolpyruvate 2503 a L-methionylaminoacyl- an aliphatic a carboxylate 3-ketoacyl-ACP CELLY_RS11685 α 2-epimerase (non- CELLY_RS13190 dehydrogenase/ a 2-methyladenine acetylmuramoyl-L-alanyl-D- D-ala formate (+)-7-epi- catalytic subunit: xanthosine salvage D-glyceraldehyde dTDP- -D-glucose 5'-deoxyadenosine met tRNA L-amino acid reductase: nucleoside- ribonucleoside- dTMP DHAP hydrolyzing): wecB enoyl-CoA in 23S rRNA glutamyl-6-carboxy-L-lysine jasmonate CELLY_RS00865 ribonucleoside- 3-phosphate GDP-β-L-fucose CELLY_RS07230 diphosphate diphosphate dTDP-glucose 4,6- hydratase diphosphate UDP-N-acetyl-[+ α2- isozymes] 2+ 2+ dehydratase: rfbB family protein: Zn RS08480 Zn a (3R)-3- kinase: reductase: reductase: xanthosine : pyk N-carbamoyl- CELLY_RS01305 CELLY_RS08400 dTDP-4-dehydro-6- D-mannosamine CELLY_RS12810 hydroxydecanoyl-[acp] CELLY_RS08400 purine-nucleoside an N-terminal (5Z,8Z,11Z,14Z,17Z) a cytidine 34 a [protein]- L-aspartate dTDP class II fructose- α UDP-N-acetyl-D- an L-phenylalanyl- isobutanoate (2E,6E)-farnesyl canavaninosuccinate CELLY_RS08405 CELLY_RS08405 phosphorylase: deoxy- -D-glucopyranose protoheme asp O-ureido-L- thr arginyl-[protein] [tRNA Phe ] -icosapentaenoyl-CoA diphosphate in tRNA L-histidine bifunctional nucleoside- bisphosphate dTDP-4- mannosamine 3-oxooctanoyl-CoA homoserine tRNA (cytidine(34) dihydroorotase: CELLY_RS04065 pyruvate : threonine UDP-3-O-[3- diphosphate xanthine aldolase: fbaA dehydrorhamnose dehydrogenase: -2'-O)- CELLY_RS13785 GTP dADP UDP-α-D-glucose Respiration acetyl-CoA C- CELLY_RS15770 ammonia- hydroxymyristoyl] N- kinase: 3,5-epimerase: rfbC wecC leucyl/phenylalanyl- acetate--CoA acyl-CoA protoheme IX argininosuccinate methyltransferase: dihydroorotase: dGDP superpathway of pyrimidine deoxyribonucleoside salvage biosynthesis acyltransferase: argininosuccinate [+ 11 isozymes] lyase acetylglucosamine CELLY_RS01305 dTDP-4-dehydro- UDP-N-acetyl-D- ligase: acs thioesterase: : lyase: argH CELLY_RS04375 CELLY_RS04975 nucleoside- CELLY_RS12805 tRNA--protein synthase: a 2'-O- a [protein]- IlvA: ilvA deacetylase/3- β-D-fructose 1,6- β-L-rhamnose mannosamine D-glucopyranose 2-oxoglutarate decarboxylation to succinyl-CoA transferase: CELLY_RS16565 cyoE N-phospho- nucleoside- diphosphate 2'-deoxycytidine dTTP acetyl-CoA C- CELLY_RS04145 methylcytidine 34 2-oxobutanoate hydroxyacyl-ACP (S)-dihydroorotate bisphosphate dTDP-4- dehydrogenase: 6-phosphate PRPP biosynthesis CELLY_RS05015 [+ 5 isozymes] L-histidine diphosphate kinase: phospho- a [2-oxoglutarate acyltransferase: in tRNA dehydratase: XMP dehydrorhamnose wecC kinase: CELLY_RS01305 nucleoside 2'-deoxycytidine class 1 fructose- sugar mutase: dehydrogenase CELLY_RS12165 isobutanoyl-CoA diphosphate L-canavanine fumarate CELLY_RS14910 quinone-dependent reductase: rfbD UDP-N-acetyl-α-D- D-ribose 5- AMP ferroheme o CELLY_RS01305 deaminase: kinase: bisphosphatase: fbp CELLY_RS12890 6 L-phenylalanyl-L- (5Z,8Z,11Z,14Z,17Z) canavaninosuccinate α-D-glucopyranose phosphate E2 protein] N 2-oxoglutarate Phe coenzyme A dihydroorotate β mannosaminuronate arginyl-[protein] a tRNA -icosapentaenoate dATP CELLY_RS08290 CELLY_RS09850 dTDP- -L-rhamnose 1-phosphate ribose-phosphate -lipoyl-L-lysine dehydrogenase hexanoyl-CoA a (2E)-dec-2-enoyl-[acp] dehydrogenase: inosine-5'-phosphate biosynthesis I F6P dGTP [+ 2 isozymes] pyrophosphokinase: 2-oxoglutarate E1 component: CELLY_RS00605 dCMP UTP--glucose- acyl-CoA CELLY_RS08530 dehydrogenase CELLY_RS09130 PRPP glucose-6- 1-phosphate dehydrogenase: 34 a [LuxE]-S- orotate 2'-deoxyuridine AIR ribose-phosphate an N-terminal a [protein]-S- a uridine UTP a uracil 1498 (d)CMP kinase: phosphate E1 component: CELLY_RS10235 an L-phenylalanyl- NAD + H O a nucleoside DNA with lesion histidinol uridylyltransferase: glu 2 (long-chain fatty CELLY_RS00885 5-(carboxyamino)imidazole pyrophosphokinase: CELLY_RS09130 L-lysyl-[protein] [tRNA Phe ] sulfanyl-L-cysteine in tRNA triphosphate nucleoside triphosphate in 16S rRNA isomerase: pgi CELLY_RS04365 acyl)-L-cysteine 16S rRNA excinuclease orotate : ribonucleotide synthase: CELLY_RS08895 (2E)-hexenoyl-CoA nucleotide histidinol D-glucopyranose [+ 2 isozymes]a [2-oxoglutarate a [2-oxoglutarate pyrophosphohydrolase: a decanoyl-[acyl-carrier protein] phosphoribosyltransferase: CELLY_RS05955 dCDP CELLY_RS10620 α PRPP pyrophosphohydrolase: (uracil(1498)-N(3))- ABC subunit dehydrogenase: 6-phosphate UDP- -D-glucose dehydrogenase dehydrogenase tRNA 2- mazG CELLY_RS02875 N5-CAIR leucyl/phenylalanyl- amino acid CELLY_RS10010 acyl-CoA methyltransferase: UvrB: uvrB hisD deoxynucleoside thymidine nucleoside- E2 protein] N 6 E2 protein] N 6 -S- thiouridine(34) nucleotide beta-ketoacyl- tRNA--protein dehydrogenase: reductase: 3 CELLY_RS13055 [+ 3 isozymes] orotate kinase: diphosphate -dihydrolipoyl- succinyldihydrolipoyl- synthase nucleoside triphosphate pyrophosphohydrolase: an N - DNA without ACP synthase superpathway of 5-aminoimidazole 5-(carboxyamino)imidazole transferase: 1498 his phosphoribosyltransferase: CELLY_RS09850 kinase: CELLY_RS10240 MnmA: mnmA pyrophosphohydrolase: CELLY_RS15015 methyluracil II: fabF ribonucleotide biosynthesis thymidine kinase: L-lysine L-lysine (S)-3- CELLY_RS05015 CELLY_RS10010 lesion ribonucleotide mutase: purE mazG in 16S rRNA CELLY_RS02870 CELLY_RS05955 CELLY_RS01305 hydroxyhexanoyl-CoA UMP beta-ketoacyl dUMP a nucleoside 5'- PRPP + 34 a [LuxE]- a long-chain synthase: deoxynucleoside dCTP CAIR 3-hydroxyhexanoyl- L-phenylalanyl- 2-oxoglutarate ammonium NADH H a [protein]- a 2-thiouridine monophosphate Phe L-cysteine fatty aldehyde orotidine 5'- amidophosphoribosyltransferase: kinase: 2-oxoglutarate CoA a tRNA L-cysteine in tRNA CELLY_RS05195 thymidylate L-lysyl-[protein] phosphate CELLY_RS06275 CELLY_RS09850 phosphoribosylaminoimidazolesuccinocarboxamide dehydrogenase dehydrogenase: 5-phospho-β- synthase: a 3-oxododecanoyl-[acp] synthase: CELLY_RS16035 E1 component: CELLY_RS12810 orotidine-5'- D-ribosylamine CELLY_RS09805 CELLY_RS09130 3 phosphate SAICAR 3-oxohexanoyl-CoA quinoxaline-2- lysine within an N -methyladenine a ribonucleoside dTTP pyridoxamine 3-oxoacyl-[acyl- phosphoribosylamine- aryl-carrier protein an octanoyl-[acp] a single a RNA-DNA hybrid acetoacetyl-CoA 2-chloroacetate decarboxylase: 2-oxoglutarate carboxyl adenylate gcv protein H in DNA triphosphate nucleoside triphosphate 5'-phosphate carrier-protein] -glycine ligase: purD acetyl-CoA C- stranded DNA 3-hydroxybutyryl- haloacid pyrF adenine and adenylosuccinate dehydrogenase pyrophosphohydrolase: pyridoxamine reductase: fabG adenosine salvage I complex acyltransferase: CoA dehalogenase GAR lyase: purB pyrimidine ribonucleosides salvage I DNA-3- mazG 5'-phosphate 3-ketoacyl-ACP UMP dihydrolipoyllysine- CELLY_RS12805 lipoyl(octanoyl) ribonuclease HII: dehydrogenase: type II: acyl carrier protein: methyladenine DNA : nucleotide oxidase: pdxH reductase: UMP kinase: AICAR residue acetyl-CoA C- transferase CELLY_RS03405 CELLY_RS16435 CELLY_RS01890 adenosine cytidine CELLY_RS06295 glycosylase I: CELLY_RS10060 pyrophosphohydrolase: (S)-3- CELLY_RS07230 CELLY_RS09220 dTMP succinyltransferase: acyltransferase: LipB: lipB glycolate PLP purine-nucleoside bifunctional CELLY_RS04505 CELLY_RS10010 hydroxybutanoyl- a (3R)-3- odhB CELLY_RS12165 CoA UDP phosphorylase: phosphoribosylaminoimidazolecarboxamide uridine nucleoside a [glycine-cleavage dTMP FGAR a quinoxaline-2- ssDNA/pppN(pN) DNA a nucleoside 5'- hydroxydodecanoyl-[acp] CELLY_RS04065 formyltransferase/IMP cyclohydrolase: purH kinase: udk deaminase: complex H protein] nucleoside- butanoyl-CoA carboxyl-[aryl- acyl-carrier protein an apurinic site hybrid monophosphate adenine CELLY_RS08290 AMP N 6 -octanoyl-L-lysine 3-methyladenine n -1 bifunctional diphosphate dTDP carrier protein] within DNA phosphoribosylformylglycinamidine FAICAR CMP acyl-CoA UDP-3-O-[3- kinase: [+ 2 isozymes] 2-oxoisovalerate decarboxylation to isobutanoyl-CoA synthase: purL nucleoside- dehydrogenase: hydroxymyristoyl] N- CELLY_RS01305 adenine bifunctional gln diphosphate uridine CELLY_RS10235 acetylglucosamine phosphoribosyltransferase: an [apo BCAA UDP-N-acetyl- UTP FGAM kinase: phosphoribosylaminoimidazolecarboxamide decaprenyl-diphospho-N- N-acetyl-4-O- CTP deacetylase/3- CELLY_RS12025 dehydrogenase α methanethiol O-succinyl-L- a peptide with a a cytosine in DNA a reduced c- a uridine in tRNA a DNA segment formyltransferase/IMP cyclohydrolase: purH uridine crotonyl-CoA -D-glucosamine acetylmuramoyl-pentapeptide acetylneuraminate CELLY_RS01305 E2 protein] N 6 homoserine nucleoside triphosphate hydroxyacyl-ACP phosphoribosylformylglycinamidine kinase: udk alpha-ketoacid penultimate glycine DNA cytosine type cytochrome tRNA CTP synthase: AMP -lipoyl-L-lysine pyrophosphohydrolase: dehydratase: cyclo-ligase: CELLY_RS01975 dTTP dehydrogenase undecaprenyldiphospho- methyltransferase: cytochrome- dihydrouridine recombinase CELLY_RS01085 IMP UMP dihydrolipoyl sialate O- mazG CELLY_RS14910 subunit alpha/beta: muramoylpentapeptide beta-N- cystathionine CELLY_RS08195 c peroxidase: synthase RecA: recA AIR dehydrogenase: carboxypeptidase: acetylesterase: nucleotide CELLY_RS07050 CTP CELLY_RS13975 acetylglucosaminyltransferase: gamma-synthase: DNA (cytosine-5-)- DusB: dusB a DNA segment lpdA (S)-3- CELLY_RS16360 CELLY_RS07850 pyrophosphohydrolase: a 5,6-dihydrouridine a (2E)-dodec-2-enoyl-[acp] murG CELLY_RS05370 methyltransferase: an oxidized c- in reverse dihydrolipoyl hydroxybutanoyl-CoA CELLY_RS10010 in tRNA dcm type cytochrome orientation dehydrogenase: (S)-3- a 5-methylcytosine Amino Acid Biosynthesis N-acetylneuraminate CMP lpdA an [apo BCAA hydroxybutanoyl- decaprenyl-pyrophosphoryl- UDP succinate a peptide with a acetate an [apo BCAA dehydrogenase met an amino acid in DNA dehydrogenase CoA (N-acetylglucosamine)-N- C-terminal glycine E2 protein] N 6 -S-[2- L-histidine biosynthesis E2 protein] N 6 dehydrogeanse: acetylmuramyl-(pentapeptide) superpathway of branched chain amino acid biosynthesis L-lysine biosynthesis I L-arginine biosynthesis III L-methionine biosynthesis III glycine biosynthesis II a dodecanoyl-[acp] -dihydrolipoyl- methylpropanoyl]dihydrolipoyl- CELLY_RS12810 (via N-acetyl-L-citrulline) a [glycine-cleavage L-lysine L-lysine PRPP an N 10 - a 2,3,4-saturated RNase III mRNA N-acetyl-9-O- a [release factor]- 4-(2'- dCDP 6 acetoacetyl-CoA an L-methionyl- a ribonucleoside thr pyruvate asp L-homoserine complex H protein] N - 1,2-diacyl-sn- processing carboxyphenyl)- acetaldehyde beta-ketoacyl- glu fatty acid β-oxidation I (generic) [initiator tRNA Met ] formyltetrahydrofolate acetylneuraminate L-glutamine diphosphate ribonucleoside- ATP : aminomethyldihydrolipoyl- CTP peptide chain 4-oxobutyryl-CoA ACP synthase Aromatic Compound Biosynthesis acetyl-CoA C- glycerol 3-phosphate substrate ribonucleoside- 1,4-dihydroxy- aldehyde phosphoribosyltransferase: biosynthetic- CELLY_RS08780 homoserine O- L-lysine diphosphate threonine acyltransferase: release factor diphosphate dehydrogenase II: fabF CELLY_RS14865 type acetyltransferase: 2-oxo acid a (3Z)-alk-3- sialate O- 2-naphthoyl- reductase: laurate ammonia- [+ 2 isozymes] glycine cleavage glycine cleavage system N(5)-glutamine (NADP(+)): beta-ketoacyl chorismate biosynthesis I acetolactate gly dehydrogenase CELLY_RS12805 enoyl-CoA methionyl-tRNA phosphatidate ribonuclease acetylesterase: reductase: CoA synthase: CELLY_RS08400 dipicolinate biosynthesis 1-(5-phospho- L-aspartyl-4-phosphate thrA aminomethyltransferase methyltransferase: CELLY_RS16210 lyase synthase: system protein subunit E2: acetyl-CoA C- formyltransferase: cytidylyltransferase: CELLY_RS08400 CELLY_RS14740 synthase: fatty acyl-CoA ∆ 3 2 III: rnc CELLY_RS07850 CELLY_RS08405 D-erythrose β-D-ribosyl)-ATP IlvA: ilvA O-acetyl-L- GcvH: gcvH GcvT: gcvT -cis-∆ -trans- CELLY_RS15945 CELLY_RS02900 prmC CELLY_RS08405 1,4-dihydroxy-2- acetate CELLY_RS05195 ilvB ilvN N-acetyl-L- CELLY_RS02450 acyltransferase: 5 a 2'- synthetase: homoserine hydrogen sulfide [+ 2 isozymes] a [release factor]-N naphthoyl-CoA CDP 4-phosphate bifunctional (2Z)-2-aminobut- aspartate- glutamate [+ 2 isozymes] CELLY_RS12165 enoyl-CoA CELLY_RS12820 bifunctional 3-deoxy-7- asp a [glycine-cleavage -methyl-L-glutamine deoxyribonucleoside phosphoribosyl- 2-enoate (S)-2-acetolactate semialdehyde a [glycine-cleavage isomerase: RNase III N-acetylneuraminate aspartate kinase: 6 an N-formyl- acetate 5'-diphosphate phosphoheptulonate acetylglutamate complex H protein] N complex H protein] N 6 CELLY_RS12810 a CDP-2,3,4-saturated- an mRNA fragment processing a 3-oxotetradecanoyl-[acp] lauroyl-CoA AMP dehydrogenase: hydrogencarbonate O-acetylhomoserine acetyl-CoA L-methionyl- a tetrahydrofolate synthase/chorismate CELLY_RS08780 ketol-acid kinase: argB -dihydrolipoyl-L-lysine -[(R)-lipoyl]-L-lysine TCA cycle TCA cycle I (prokaryotic) diacylglycerol cyclohydrolase/ CELLY_RS05940 [initiator tRNA met ] mRNA mutase type II: [+ 2 isozymes] reductoisomerase: aminocarboxypropyltransferase/ 3-oxoacyl-[acyl- L-aspartyl- phosphoribosyl- L-aspartate 4- carbamoyl- N-acetylglutamyl- cysteine synthase: CELLY_RS09980 ilvC acetyl-CoA a (2E)-2- carrier-protein] 3-deoxy- 4-phosphate ATP diphosphatase 2-iminobutanoate semialdehyde phosphate CELLY_RS09870 (2R)-2,3- phosphate enoyl-CoA a [glycine-cleavage a 3,5,7,9,11,13,15- 2251 reductase: fabG D-arabino- HisIE: synthase L-ascorbate a [protein] C- a uracil in DNA guanosine L-malic UDP dihydroxy-3- a 2,3,4-saturated a sulfurated [sulfur carrier] SAM complex H protein] a tRNA precursor hepta-oxo- an oligopeptide heptulosonate aspartate- CELLY_RS14830 4-hydroxy- large N-acetyl-gamma- oxaloacetate terminal glycine in 23S rRNA semialdehyde ribonucleoside- 3-ketoacyl-ACP methylbutanoate glycine cleavage system L-alanine fatty acid acyl-CoA a 2,3,4- N 6 -octanoyl-L-lysine hexadecanoyl-[PKS-acp] 23S rRNA aldehyde 7-phosphate semialdehyde tetrahydrodipicolinate glutamyl-phosphate L-homocysteine fatty acyl-CoA aldo/keto reductase: 1-(5-phospho-β- subunit: carB aminomethyltransferase biosynthesis III dehydrogenase: saturated (3R)-3- oligopeptidase B: diphosphate dehydrogenase: dihydroxy-acid synthase: reductase: citrate synthase: synthetase: reductase: (guanosine(2251) dehydrogenase CELLY_RS07230 3-dehydroquinate peptidylglycine uracil-DNA CELLY_RS13685 reductase: CELLY_RS05940 D-ribosyl)-AMP dehydratase: CELLY_RS16520 glutamine- GcvT: gcvT CELLY_RS10925 CELLY_RS12820CELLY_RS10235 a 2,3,4- hydroxyacyl-CoA -2'-O)- (NADP(+)): synthase: aroB 2-oxobutanoate CELLY_RS04150 5-methyltetrahydropteroyltriglutamate- malate dehydrogenase a 2,3,4-saturated lipoyl monooxygenase: ribonuclease Z: glycosylase: CELLY_RS15735 CELLY_RS08400 a (3R)-3- CDP-diacylglycerol bifunctional ilvD (2S,4S)-4- hydrolyzing N-acetyl-L- [+ 4 isozymes] cys saturated (3S)-3- methyltransferase CELLY_RS16210 L-aspartate 4- methionine - homocysteine S- (quinone): mqo fatty acyl CoA synthase: lipA CELLY_RS11710 CELLY_RS00855 CELLY_RS14720 9-hydroxy-3,5,7,11,13,15-[+ 2 isozymes] CELLY_RS08405 biosynthesis I hydroxy-2,3,4,5- carbamoyl- glutamate 5- cysteine desulfurase: hydroxyacyl-CoA RlmB: rlmB a peptide hydroxytetradecanoyl-[acp] 3-dehydroquinate semialdehyde phosphoribosyl- biosynthetic- 3-methyl-2- synthase: malate dehydrogenase: 3-hydroxyacyl-CoA 2-O- (S)-malate tetrahydrodipicolinate phosphate methyltransferase: metE CELLY_RS00120 acetyl-CoA C- hexaoxohexadecanoyl- dUDP type oxobutanoate semialdehyde CELLY_RS11515 2251 AMP metH dehydrogenase: a [protein] C- [PKS-acp] methylguanosine bifunctional DHAP 4-hydroxy- 4-hydroxy- synthase N-acetylornithine methionine cysteine desulfurase: acyltransferase: a [glycine-cleavage monodehydroascorbate an apyrimidinic uracil type II 3- cyclohydrolase/ acetolactate CELLY_RS12810 a single-stranded in 23S rRNA UDP-3-O-[3- NAD(P)H- synthase: CELLY_RS12165 5'-deoxyadenosine 6 an unsulfurated terminal (2S)-2- dehydroquinate tetrahydrodipicolinate phosphoribosyl- synthase: 2-isopropylmalate branched-chain tetrahydrodipicolinate small aminotransferase: CELLY_RS07620 (S)-malate citrate coenzyme A met complex H protein] N radical mature tRNA site in DNA hydroxymyristoyl] N- dependent glycerol- metH [sulfur carrier] hydroxyglycine oligoribonucleotide dehydratase: aroQ synthase: ATP diphosphatase ilvB ilvN synthase: amino acid reductase: dapB subunit: carA CELLY_RS04160 ala a 2,3,4-saturatedacetyl-CoA C-a 2,3,4-saturated -[(R)-lipoyl]-L-lysine acetylglucosamine 3-phosphate CELLY_RS16520 (S)-2,3,4,5- superpathway of L- fatty acyl CoA acyltransferase:3-oxoacyl-CoA HisIE: (S)-2-aceto-2- CELLY_RS13865 aminotransferase: carbamoyl N-acetyl-L- deacetylase/3- dehydrogenase: 3-dehydroshikimate (2S,4S)-4- tetrahydrodipicolinate met asparagine biosynthesis CELLY_RS12805 CELLY_RS14830 hydroxybutanoate 2-isopropylmalate CELLY_RS01695 phosphate ornithine hydroxyacyl-ACP CELLY_RS05560 hydroxy-2,3,4,5- aconitate hydratase: a [pyruvate dehydrogenase E2 a single- a cytidine 1402 an [amino-group carrier a negatively 1-(5-phospho-β-D-ribosyl)- 2,3,4,5- lipid IV (E. coli) CMP-Kdo + sn-glycerol synthase: 6 A FMN NAD(P)H H protein]-C-terminal-γ- an aldehyde CAIR dehydratase: tetrahydrodipicolinate ketol-acid L-arginine asp CELLY_RS02350 a sulfurated [sulfur carrier] SAM protein] N -octanoyl-L-lysine stranded RNA in 16S rRNA supercoiled DNA 3-phosphate 5-[(5-phosphoribosylamino) tetrahydropyridine- class II fumarate CELLY_RS14910 reductoisomerase: CELLY_RS13450 acetylornithine degradation I 16S rRNA (L-glutamyl)-L-glutamate DNA aldehyde 5-(carboxyamino) methylideneamino]imidazole- val 2,6-dicarboxylate N- L-glutamate biosynthesis III hydratase: fumC ilvC carbamoyltransferase: (cytidine(1402)-2'-O) acetylglutamate topoisomerase 3: dehydrogenase imidazole 4-carboxamide (arginase pathway) fumarate cis-aconitate acetyl-CoA 3-deoxy-D-manno- polyribonucleotide a (2E)-tetradec-2-enoyl-[acp] shikimate (2S)-2- succinyltransferase: CELLY_RS04165 flavin reductase: -methyltransferase: CELLY_RS04750 (NADP(+)): ribonucleotide dipicolinate (R)-2,3-dihydroxy- asparagine asparagine octulosonic acid : kinase: argB 1-(5-phosphoribosyl)-5- isopropylmalate CELLY_RS00375 arg aconitate hydratase: CELLY_RS15865 rsmI [+ 2 isozymes] CELLY_RS16210 mutase: purE a 1-acyl-sn 3-methylpentanoate synthase synthase 2-oxoglutarate succinate lipoyl synthase: lipA transferase: a 2'-O- an [amino-group carrier [(5- phosphoribosylamino) N-succinyl-2-amino- NADP-specific glutamate CELLY_RS02350 CELLY_RS03285 dihydroxy-acid 3-isopropylmalate B: asnB (glutamine- CELLY_RS08135 1402 protein]-C-terminal- a relaxed DNA a carboxylate AIR -glycerol 3- methylideneamino]imidazole-4- N-acetyl- dehydrogenase/ methylcytidine dehydratase: dehydratase: 6-ketopimelate hydrolyzing) dehydrogenase: gdhA γ-(5-phospho-L- phosphate carboxamide isomerase: hisA L-citrulline asparagine fumarate reductase in 16S rRNA leuD leuC glutamate synthase a single- + 1-acyl-sn-glycerol- shikimate 3- ilvD L-ornithine : asnB iron-sulfur subunit: Inorganic Nutrient Metabolism a [pyruvate dehydrogenase α a nucleoside FMNH NAD(P) glutamyl)-L-glutamate synthase 5'-deoxyadenosine CMP -Kdo-(2->6)- 2 phosphate phosphoribulosylformimino- large subunit: gltB met 6 an unsulfurated [sulfur carrier] diphosphate stranded RNA a myristoyl-[acp] 3-phosphate (3S)-3-methyl-2- 2-isopropylmaleate (glutamine- asparagine CELLY_RS07080 E2 protein] N -lipoyl-L-lysine lipid IV (E. coli) AICAR-phosphate A acyltransferase: 3-phosphoshikimate 1- ornithine- hydrolyzing) glu oxopentanoate N-succinyl-L,L-2,6- synthase succinate D-threo-isocitrate selenate reduction beta-ketoacyl- CELLY_RS00995 carboxyvinyltransferase: branched-chain 3-isopropylmalate diaminopimelate -oxo-acid : asnB B: asnB NADP-dependent thiosulfate oxidation III (multienzyme complex) ACP synthase imidazole dehydratase: L-citrulline transaminase: a [protein]- [+ 3 isozymes] CELLY_RS10015 amino acid ADP-forming isocitrate a 1-(1-alkenyl) a cytidine 1402 a double-stranded a [protein]-L- a 1,2-diacyl- glycerol selenate a 5-L-glutamyl- glutathione NADP + FMNH arsenate II: fabF 5-enolpyruvoyl- leuD leuC rocD -sn-glycero-3- 2 L-tyrosine aminotransferase: succinate--CoA ligase dehydrogenase: sulfate a [SoxY protein]-L-cysteine an amino acid hypoglycin A in 16S rRNA oligonucleotide proline (ω = 180) sn-glycerol shikimate 3- phosphate argininosuccinate asn asn [peptide] phosphocholine 16S rRNA bifunctional peptidylprolyl phosphate arsenate beta-ketoacyl CELLY_RS01695 (2R,3S)-3- L-glutamate-5- subunit beta: sucC CELLY_RS00075 adenylyltransferase 3-phosphate phosphate synthase: synthase: (cytosine(1402)-N(4) oligoribonuclease/ isomerase: protein-tyrosine- reductase synthase: isopropylmalate semialdehyde succinate--CoA ligase subunit CysD: cysD phosphatidate chorismate hisF hisH L,L-diaminopimelate CELLY_RS04145 PAP phosphatase CELLY_RS00665 phosphatase: CELLY_RS05195 ile 3-isopropylmalate subunit alpha: sucD adenosine 5'- flavin reductase: )-methyltransferase (glutaredoxin) cytidylyltransferase: synthase: L-glutamate gamma- gamma- lysoplasmalogenase: CELLY_RS00535 L-arginino- phosphoselenate CELLY_RS15865 4 RsmH: rsmH NrnA: [+ 7 isozymes] : arsC dehydrogenase: diaminopimelate an N - a 3-oxohexadecanoyl-[acp] CELLY_RS02900 aroC D-erythro-1- succinate gamma- succinyl-CoA 2-oxoglutarate a [SoxY protein]-S- glutamyltransferase: ggt glutamyltransferase: ggt CELLY_RS03225 CELLY_RS01315 a [protein]-L- a [protein]- AICAR leuB methylcytidine 1402 arsenite a CDP- (imidazol-4- epimerase: semialdehyde sulfosulfanyl-L-cysteine a nucleoside 5'- proline (ω = 0) L-tyrosine chorismate yl)-glycerol 3-isopropylmalate CELLY_RS00035 argininosuccinate dehydrogenase: in 16S rRNA 3-oxoacyl-[acyl- diacylglycerol L-cysteine biosynthesis I an α-(5-L- FMN NADPH + monophosphate 3-phosphate dehydrogenase: lyase: argH pruA cytochrome c: sn-glycero-3- H carrier-protein] selenite glutamyl)- a peptide hypoglycin B L-cysteinylglycine a fatty aldehyde bifunctional L-proline leuB meso-diaminopimelate L-tryptophan biosynthesis CELLY_RS05330 phosphocholine reductase: fabG biosynthesis I 2-oxoglutarate amino acid histidinol- (2S)-2-isopropyl- arg glu ser cytochrome c: 3-ketoacyl-ACP dehydrogenase phosphatase/ (from L-glutamate) 3-oxosuccinate diaminopimelate CELLY_RS09340 reductase: gln serine acetyltransferase: E1 component: imidazoleglycerol- decarboxylase: lysA chorismate UDP-N-acetyl-α-D-glucosamine undecaprenyl-diphospho-N RNase R degradation a DNA containing adenine 1618 N,N'- α-D-glucosamine CELLY_RS07230 glu CELLY_RS14790 CELLY_RS09130 a [SoxY protein]-S- a [SoxY protein]-S + L-2,4- a phosphate phosphate -acetylmuramoyl-L-alanyl-γ- an apurinic/ FMN NADH H diacetylchitobiose 6-phosphate biotin-carboxyl carrier selenodiglutathione disulfanyl-L-cysteine -sulfanyl-L-cysteine substrate RNA in 23S rRNA diaminobutanoate monoester a (3R)-3- glutamate 5- L-homoserine O-acetyl-L-serine D-glutamyl-L-lysyl- D-alanine apyrimidinic site 23S rRNA chitobiase/beta- glucosamine- dehydratase lys anthranilate synthase: alkaline protein assembly kinase: proB 4-methyl-2- biosynthesis hexosaminidase amino acid hydroxyhexadecanoyl-[acp] HisB: hisB γ undecaprenyldiphospho- (adenine(1618)-N(6) 6-phosphate -L-glutamyl oxopentanoate CELLY_RS02755 L-tyrosine biosynthesis I O-acetylhomoserine C-terminal domain- decarboxylase: phosphatase: a [biotin carboxyl- 3-(imidazol-4- muramoylpentapeptide beta-N- ribonuclease flavin reductase: )-methyltransferase deaminase: bifunctional 5-phosphate aminocarboxypropyltransferase/ endonuclease III: containing protein: CELLY_RS09625 CELLY_RS12305 carrier protein]-L-lysine yl)-2-oxopropyl branched-chain asp R: rnr CELLY_RS15865 6 RlmF: rlmF nagB UDP-3-O-[3- acetylglucosaminyltransferase: CELLY_RS13745 an N - propane- phosphate glutamate-5- amino acid anthranilate PRPP cysteine synthase: glutathioselenol polyphosphate CELLY_RS11700 an alcohol biotin--[acetyl-CoA- aspartate kinase: chorismate urea cycle murG methyladenine 1618 F6P hydroxymyristoyl] N- semialdehyde CELLY_RS09870 metabolism N-acetyl-D- 1,3-diamine carboxylase] ligase: histidinol- aminotransferase: CELLY_RS08780 superpathway of L-serine bifunctional 3-deoxy-7- in 23S rRNA acetylglucosamine dehydrogenase: a [SoxY protein]-S-(2- glucosamine CELLY_RS02880 phosphate CELLY_RS01695 [+ 2 isozymes] and glycine biosynthesis I phosphoheptulonate cysteine synthase ditrans,octacis-undecaprenyldiphospho- a diribonucleotide a nucleoside 5'- FMNH NAD + deacetylase/3- anthranilate long chain UDP a 3'-terminal a 5'-phospho- 2 CELLY_RS03305 L-aspartyl- CysM: cysM sulfodisulfanyl)-L-cysteine monophosphate a [biotin carboxyl- transaminase: synthase/chorismate polyphosphate arg ammonium N-acetyl-(N-acetylglucosaminyl)muramoyl- unsaturated sugar [DNA] hydroxyacyl-ACP 4-phosphate phosphoribosyltransferase: trpD carrier protein]-N hisC L-glutamate-5- leu 3-phospho-D-glycerate mutase type II: L-alanyl-γ-D-glutamyl-L-lysyl-D-alanine dehydratase: cys 6 -biotinyl-L-lysine hydrogen selenide carbamoyl- CELLY_RS14910 L-histidinol semialdehyde aspartate- phosphoglycerate CELLY_RS09980 alanine dehydrogenase: serA N-(5-phosphoribosyl)-anthranilate prephenate polyphosphate argininosuccinate phosphate synthase phosphate semialdehyde racemization UDP-N-acetyl-α-D-glucosamine undecaprenyl-diphospho-N-acetylmuramoyl-L- 5-amino-4- 4-fumaryl- a mismatched [+ 2 isozymes] kinase: lyase: argH large subunit: carB γ PRPP coenzyme A a holo [PedD acyl- prephenate a (2E)-hexadec-2-enoyl-[acp] dehydrogenase: alanyl- -D-glutamyl-L-lysyl- D-alanyl-D-alanine imidazolecarboxyamide acetoacetate DNA base pair an L-amino acid ser bifunctional 3-phosphooxypyruvate phosphoribosylanthranilate prephenate CELLY_RS00675 carrier protein] a [biotin carboxyl- CELLY_RS05940 ala glutamine- DNA mismatch prephenate histidinol- isomerase: CELLY_RS02775 dehydrogenase: undecaprenyldiphospho- L-serine carrier-protein dimer]- (S)-1-pyrroline- ammonia alanine [+ 3 isozymes] hydrolyzing ACP S- repair protein MutS: amino acid phosphatase/ L-aspartate 4- 3-phosphoserine/ CELLY_RS09975 sulfur muramoylpentapeptide beta-N- adenine dehydratase: N 6 -biotinyl-L-lysine 5-carboxylate assimilation cycle III 1-(2-carboxyphenylamino)-1- L-arginino-succinate L-ornithine carbamoyl- CoA pyrophosphatase: fumarylacetoacetase: malonyltransferase: CELLY_RS09120 dehydrogenase: ammonia-lyase: imidazoleglycerol- semialdehyde phosphohydroxythreonine 3-(4- racemase: reduction II (via acetylglucosaminyltransferase: CELLY_RS09965 deoxy-D-ribulose 5-phosphate phosphoribosyltransferase: fabD [+ 2 isozymes] CELLY_RS10240 CELLY_RS13485 acetyl-CoA pyrroline-5- hydroxyphenyl) alr polysulfide) phosphate synthase CELLY_RS01000 fahA a malonyl- a properly phosphate bifunctional transaminase: serC long chain murG CELLY_RS12025 a 2-oxo 3-phenyl-2- carboxylase carboxylate glu indole-3-glycerol phosphate pyruvate D-ala small subunit: carA pyruvate a palmitoyl-[acp] dehydratase ammonium S 0 [PedD acyl- matched carboxylate oxopropanoate aspartate kinase/ synthase TrpC: trpC polyphosphate biotin HisB: hisB reductase: O-phospho-L-serine tyrosine carrier protein] DNA base pair acetyl-CoA homoserine carbamoyl phosphate ditrans,octacis-undecaprenyldiphospho-N- UDP carboxylase proC aminotransferase: L-threonine AICAR 3',5'-ADP 4'-phosphopantetheine acetoacetate fumarate carboxylase dehydrogenase argininosuccinate acetyl-(N-acetyl-β-D-glucosaminyl)muramoyl-L- subunit: accC histidinol glutamine (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate CELLY_RS09970 biosynthesis pyrroline-5- I: thrA phosphoserine synthase: γ carboxyltransferase synthetase III: a polysulfide alanyl- -D-glutamyl-L-lysyl-D-alanyl-D-alanine subunit beta: acetyl-CoA carboxylate phosphatase: serA CELLY_RS04145 histidinol CELLY_RS12045 bifunctional tryptophan synthase: tyr palmitate carboxylase reductase: L-homoserine polysulfide L-citrulline CELLY_RS03275 dehydrogenase: aspartate kinase/ biotin proC trpB CELLY_RS02785 7,8-dihydrofolate adenine 1518 / a guanine 527 D-ribose 5- hisD ser : reductase dethiobiotin a sulfurated NADPH H + nicotinate PRPP a holo [PedN acyl- homogentisate fatty acyl-CoA homoserine SAM 1519 ethylphosphate phosphate carboxylase ser CELLY_RS12125 NrfD: nrfD [sulfur carrier] monoglutamate adenine in 16S rRNA carrier protein] in 16S rRNA synthetase: gln dehydrogenase indole 16S rRNA 16S rRNA ribose 5- subunit: accC histidinal pro serine O-phospho- alkaline homogentisate CELLY_RS12820 I: thrA a polysulfide (adenine(1518)-N(6)/ ACP S- (guanine(527)-N(7) phosphate a [carboxyl-carrier glutamate hydroxymethyltransferase: L-homoserine dihydrofolate nicotinate phosphatase: 1,2-dioxygenase: 6 biotin adenine(1519)-N(6))- malonyltransferase: )-methyltransferase protein dimer]-N - histidinol CELLY_RS13370 tryptophan synthase: CELLY_RS04360 isomerase palmitoyl-CoA synthase large L-homoserine reductase: phosphoribosyltransferase: fabD CELLY_RS12305 dehydrogenase: threonine synthase dimethyltransferase 7 RsmG: rsmG B: rpiB carboxybiotinyl-L-lysine subunit: gltB trpB CELLY_RS02785 Carboxylate Degradation CELLY_RS09800 CELLY_RS08525 a malonyl[PedN an N - 4-maleyl- D-ribulose hisD gly synthase: thrC BioB: bioB RsmA: rsmA 527 ethanol N 6 -dimethyladenine 1518 acyl-carrier methylguanine acetoacetate 5-phosphate glu /N 6 -dimethyladenine 1519 protein] in 16S rRNA his trp thr propanoyl CoA 5,6,7,8- + pyruvate decarboxylation to acetyl CoA I mevalonate degradation biotin 5'-deoxyadenosine met an unsulfurated NADP NaMN in 16S rRNA degradation I [sulfur carrier] tetrahydrofolate a [pyruvate propanoyl-CoA (R)-mevalonate dehydrogenase acyl-CoA E2 protein] N 6 pyruvate hydroxymethylglutaryl-CoA α an (R)-2- a guanine 46 (2S)- a ribonucleoside carboxylase UDP-N-acetyl- -D-muramoyl- D-alanyl-D-alanine F6P [DNA] a diphthine-[translation chloramphenicol -lipoyl-L-lysine halocarboxylate in tRNA ethylmalonyl-CoA subunit beta: reductase, degradative: L-alanyl-γ-D-glutamyl-L-lysine 2] 5'-monophosphate dihydrolipoyl dehydrogenase: DNA polymerase tRNA chloramphenicol methylmalonyl- CELLY_RS12185 CELLY_RS04000 5'/3'- (S)-methylmalonyl- CELLY_RS14690 IV: dinB diphthine-- (guanosine(46)-N7) dehydrogenase: fructose-6- HAD family acetyltransferase: CoA nucleotidase HMG-CoA UDP-N-acetylmuramoyl- DNA polymerase III ammonia ligase: -methyltransferase CoA lpdA [+ 2 isozymes] CELLY_RS11865 epimerase: mce SurE: surE tripeptide--D-alanyl- phosphate hydrolase: CELLY_RS00960 TrmB: trmB methylmalonyl- dihydrolipoyl subunit gamma/tau: a diphthamide- an N 7 - chloramphenicol (2R)- D- alanine ligase: aldolase: fsa CELLY_RS12980 a ribonucleoside CoA dehydrogenase: hydroxymethylglutaryl-CoA CELLY_RS12945 [translation methylguanine 46 3-acetate ethylmalonyl-CoA a [pyruvate CELLY_RS10395 a 2'-deoxyribonucleoside epimerase: mce lpdA a [pyruvate lyase: CELLY_RS00590 elongation factor 2] in tRNA pyruvate dehydrogenase D-glyceraldehyde an (S)-2- 5'-monophosphate (R)-methylmalonyl- dehydrogenase dehydrogenase dihydroxyacetone a halide anion E2 protein] N 6 -S- UDP-N-acetyl-α-D-muramoyl-L-alanyl- 3-phosphate hydroxycarboxylate CoA E2 protein] N 6 - complex acetyldihydrolipoyl- acetoacetate acetyl-CoA γ-D-glutamyl-L-lysyl-D-alanyl-D-alanine dihydrolipoyl-L-lysine methylmalonyl- dihydrolipoamide L-lysine CoA mutase: acetyltransferase: acetate conversion a 1-O-(alk-1-enyl)-sn-glycero- an (S)-2- a guanine 37 CELLY_RS01210 CELLY_RS10420 a proteinogenic leukotriene-C4 7,8-dihydroneopterin a holo [BryP acyl- reduced riboflavin MeOH 15-cis-phytoene to acetyl-CoA 3-phosphoethanolamine halocarboxylate 2',3'-cyclic phosphate in tRNA methylmalonyl- amino acid carrier protein] tRNA acetate polyprenol phytoene CoA ACP S- (guanosine(37)-N1) flavin reductase: catalase: acetate- HAD family phosphomannose- desaturase: mutase: scpA lysoplasmalogenase: malonyltransferase: -methyltransferase CELLY_RS15865 CELLY_RS15225 -CoA hydrolase: dependent alpha 1,6 crtI acetyl-CoA gamma- CELLY_RS03225 fabD TrmD: trmD succinyl-CoA ligase: acs mannosyltransferase a malonyl- an N 1 - 9,15,9'-tri-cis glutamyltransferase: ggt CELLY_RS12980 riboflavin formaldehyde acetyl-CoA MptB: mptB [BryP acyl- methylguanine 37 -ζ-carotene 7,8-dihydroneopterin carrier protein] in tRNA sn-glycero-3- an (S)-2- an α-(γ-L-glutamyl) a fatty aldehyde a halide anion 2'-phosphate leukotriene-D4 phosphoethanolamine hydroxycarboxylate Carbohydrate Degradation -L-amino acid

D-galactose degradation I (Leloir pathway) D-glyceraldehyde D-sedoheptulose a long-chain guanine 37 (indol-3-yl) nicotinate adenine agarose degradation a proteinogenic glutathione NADPH H + 7,8-dihydroneopterin a holo [BryU acyl- ethanol 3-phosphate 7-phosphate fatty acyl-CoA Phe amino acid 2',3'-cyclic phosphate carrier protein] in tRNA acetamide dinucleotide β-D-galactopyranose polyprenol tRNA NAD(+) an agarose ACP S- amidase: catalase: phosphomannose- (guanosine(37)-N1) synthase: hypothetical acyl-CoA malonyltransferase: CELLY_RS02405 CELLY_RS15225 galactose transketolase: dependent alpha 1,6 -methyltransferase nadE mutarotase: protein: gamma- CELLY_RS01995 reductase: fabD TrmD: trmD mannosyltransferase a malonyl- an N 1 - CELLY_RS02080 CELLY_RS02160 glutamyltransferase: ggt CELLY_RS15015 (indol-3-yl)acetate acetaldehyde NAD + MptB: mptB [BryU acyl- methylguanine 37 [+ 2 isozymes] beta-agarase: 7,8-dihydroneopterin carrier protein] in tRNA Phe CELLY_RS02240 D-ribose 5- D-xylulose a long-chain 3'-phosphate α a neoagaro- an α-(γ-L-glutamyl) -D-galactopyranose L-cysteinylglycine phosphate 5-phosphate fatty aldehyde oligosaccharide -L-amino acid : neoagaro- galK oligosaccharide (1R,6R)-6-hydroxy-2- 1,3-α-3,6-anhydro- a lipid II a peptidoglycan D-xylulose D-erythrose an (R)-2- 1-aminocyclopropane- a 2'- phosphoenol α succinylcyclohexa-2,4- citrate an aryl sulfate -D-galactose 5-phosphate 4-phosphate halocarboxylate 1-carboxylate deoxyribonucleoside pyruvate UDP-α-D-glucose L-galactosidase: diene-1-carboxylate 1-phosphate 1-aminocyclopropane- deoxynucleoside aconitate sulfatase: CELLY_RS02045 o-succinylbenzoate pyruvate penicillin-binding HAD family 1-carboxylate kinase: hydratase: CELLY_RS02065 transketolase: synthase: kinase: pyk agarobiose protein 2: hydrolase: deaminase/D-cysteine CELLY_RS09850 CELLY_RS02350 [+ 6 isozymes] CELLY_RS01995 CELLY_RS13560 CELLY_RS03925 desulfhydrase: a 2'- CELLY_RS12980 D-threo-isocitrate a phenol pyruvate CELLY_RS03470 2-succinylbenzoate deoxyribonucleoside 5'-monophosphate di-trans,octa-cis D-glyceraldehyde 2-oxobutanoate a peptidoglycan F6P a (2R)-2- -undecaprenyl 3-phosphate a halide anion diphosphate hydroxy fatty acid

a [histone]-N 6 - DNA combined with D-threo-7,8- D-arabinofuranose a uracil 1939 (2R,3S)-3- NAD + propionamide D-glucopyranose acetyl-L-lysine exogenous DNA to form dihydroneopterin D-cysteine 5-phosphate in 23S rRNA isopropylmalate a recombinational junction Holliday junction 1-aminocyclopropane-1- 3-deoxy-8- 23S rRNA 3-isopropylmalate xylose amidase: resolvase RuvX: ruvX carboxylate deaminase/D- phosphooctulonate (uracil(1939)-C(5)) dehydratase: isomerase: UDP-glucose NAD-dependent CELLY_RS02405 dihydroneopterin synthase: kdsA -methyltransferase leuD leuC xylA UDP-glucose-- 4-epimerase deacylase: crossover junction cysteine desulfhydrase: aldolase: folB RlmD: rlmD (2S)-2- hexose-1-phosphate GalE: galE CELLY_RS00695 endodeoxyribonuclease CELLY_RS03470 a 5-methyluracil 1939 propanoate keto-D-fructose KDO-8P isopropylmalate uridylyltransferase: UDP-glucose resolution of recombinationalRuvC: ruvC pyruvate in 23S rRNA CELLY_RS11860 4-epimerase 2''-O-acetyl- junction formation 6-(hydroxymethyl) glycolaldehyde α-D-glucopyranose a [histone]-L-lysine nicotinamide of two intact strands UDP-α-D-galactoseGalE: galE ADP-ribose -7,8-dihydropterin 1-phosphate

phospho- 6 a glucosylated an [amino-group carrier protein]- + a [protein]-N - α 2-dehydro-3-deoxy- cytidine sugar mutase: NAD UDP- -D-glucose γ (R)-mevalonate chloroacetaldehyde a 28S rRNA pyrazinamide acetyl-L-lysine glycogenin C-terminal- -(L-glutamate 5- D-galactonate CELLY_RS12890 porphyran degradation semialdehyde-2-yl)-L-glutamateN-acetyl-gamma- 2-dehydro-3- aldehyde RICIN domain- uridine : dehydrogenase amidase: kinase: udk D-glucopyranose NAD-dependent glycogen/starch glutamyl-phosphate deoxygalactonokinase: containing protein: a porphyran CELLY_RS04220 (NADP(+)): CELLY_RS02405 6-phosphate deacylase: synthase: reductase: CELLY_RS09055 CELLY_RS16795 2-dehydro-3-deoxy- CELLY_RS16210 CMP CELLY_RS00695 CELLY_RS05295 an [amino-group carrierCELLY_RS04150 protein]- (R)-5- a 28S rRNA pyrazine-2- β-porphyranase: C-terminal-γ-(5-phospho- D-galactonate phosphomevalonate 2-chloroacetate fragments carboxylate CELLY_RS02160 L-glutamyl)-L-glutamate 6-phosphate 2''-O-acetyl- a glucosylated UDP nicotinamide a [protein]-L-lysine glycogenin α-L- a neoagaro- ADP-ribose galactopyranose- oligosaccharide 6-sulfate-(1,3) β 3-methyl-2- 5,10-methylene- a pseudouridine 1915 D-ribulose uridine - -D-galactose seleno-L- (R)-mevalonate 2-hydroxyisobutyramide 4-nitrocatecholsulfate pyruvate oxobutanoate tetrahydromethanopterin in 23S rRNA diphosphate 5-phosphate homocysteine 23S rRNA an agarose sulfatase: ribulose-phosphate pyruvate uridine 5-methyltetrahydropteroyltriglutamate- amidase: 3-methyl-2-oxobutanoate (pseudouridine(1915)- diphosphomevalonate CELLY_RS02065 3-epimerase: carboxylase: kinase: udk - homocysteine S- CELLY_RS02405 hydroxymethyltransferase: N(3))-methyltransferase decarboxylase: mvaD [+ 6 isozymes] CELLY_RS10215 CELLY_RS02820 hypothetical hypothetical methyltransferase: metE RlmH: rlmH UMP panB an N 3 - 2-hydroxy-2- D-xylulose protein: protein: 4-nitrocatechol oxaloacetate SeMet methylpseudouridine 1915 IPP methylpropanoate 5-phosphate CELLY_RS02160 CELLY_RS02160 in 23S rRNA beta-agarase: beta-agarase: 2-dehydropantoate THMPT CELLY_RS02240 CELLY_RS02240

neoagarobiose neoagarohexaose a generic 2-amino-6-[1-hydroxyethyl]- a uridine 55 α-L- neoagarotetraose uroporphyrinogen-III uroporphyrinogen-I N-ethylmaleimide acrylamide polynucleotide substrate 7-methyl-7,8-dihydropterin in tRNA rhamnopyranose neoagarotetraose neoagarohexaose uroporphyrinogen-III C- 2-amino-4-hydroxy-6- tRNA L-rhamnose neoagarobiose 1,3-α-3,6-anhydro- 1,3-α-3,6-anhydro- methyltransferase: cobA uroporphyrinogen alkene reductase: amidase: hydroxymethyldihydropteridine pseudouridine(55) mutarotase: 1,3-α-3,6-anhydro- L-galactosidase: L-galactosidase: decarboxylase: hemE CELLY_RS14465 CELLY_RS02405 S1/P1 nuclease: diphosphokinase: folK uroporphyrinogen-III C- synthase TruB: truB CELLY_RS02090 L-galactosidase: CELLY_RS02045 CELLY_RS02045 β-L- CELLY_RS02530 [1-(2-amino-7-methyl-4-oxo- methyltransferase: cobA a pseudouridine 55 CELLY_RS02045 7,8-dihydro-3H-pteridin- coproporphyrinogen I N-ethylsuccinimide rhamnopyranose acrylate agarotriose agaropentaose precorrin-2 in tRNA 6-yl)]ethyl diphosphate 3,6-anhydro-α-L- D-galactopyranose galactopyranose a 5'-phosphomononucleotide a 5'-phosphooligonucleotide

D-xylose 3-(4- a 5-carboxymethylaminomethyluridine 34 a uridine 2604 β degradation I glycyl-glycine glutathione hydroxyphenyl) 4-guanidinobutyramide a folate GDP- -L-fucose acetamide Detoxification in tRNA Leu in 23S rRNA D-mannose degradation pyruvate tRNA (cytidine(34) 23S rRNA dihydrofolate GDP-L-fucose D-xylose -2'-O)- amidase: amidase: D-mannopyranose arsenate reactive oxygen species degradation 4-hydroxyphenylpyruvate pseudouridine(2604) reductase: synthase: xylose arsenate methyltransferase: CELLY_RS02405 CELLY_RS02405 6-phosphate detoxification gamma- dioxygenase: hppD synthase RluF: rluF CELLY_RS09800 CELLY_RS13190 class I mannose- isomerase: detoxification V GDP-4-dehydro- II (glutaredoxin) glutamyltransferase: ggt CELLY_RS04375 a pseudouridine 2604 xylA superoxide a 5-carboxymethylaminomethyl- 4-guanidinobutanoate a 7,8-dihydrofolate α-D-rhamnose acetate 6-phosphate homogentisate in 23S rRNA isomerase: D-xylulose arsenate arsenate 2'-O-methyluridine 34 in tRNA Leu arsenate superoxide dismutase: glyceraldehyde- γ-L-glutamyl- CELLY_RS02565 carbohydrate L-cysteinylglycine reductase CELLY_RS06265 3-phosphate glycylglycine F6P kinase: (glutaredoxin) dehydrogenase: CELLY_RS15535 : arsC hydrogen peroxide CELLY_RS00045 D-xylulose 1-arseno-3- 2,5-diamino-6-(5- 10 β-D-glucopyranose 2'-deoxycytidine arsenite 4a-hydroxy-N - 3-phenyl-2- oxaloacetate a monocarboxylic (S)-malate 5-phosphate phosphoglycerate phospho-D-ribitylamino) 1-phosphate catalase: formyltetrahydrofolate oxopropanoate acid amide deoxynucleoside pyrimidin-4(3H)-one 4a-hydroxytetrahydrobiopterin beta- malate CELLY_RS15225 bifunctional 4-hydroxyphenylpyruvate citrate synthase: amidase: kinase: dehydratase: phosphoglucomutase: dehydrogenase diaminohydroxyphosphoribosylaminopyrimidine dioxygenase: hppD CELLY_RS10925 CELLY_RS02405 CELLY_RS09850 pgmB (quinone): mqo H O hydroxyl radical 1-arseno-3- deaminase/5-amino-6-(5-phosphoribosylamino) CELLY_RS01440 dCMP arsenite O 2 an N 10 -formyl- (2-hydroxyphenyl) β-D-glucose 1,2-dihydroxypropane- 2 phosphoglycerate uracil reductase RibD: ribD a monocarboxylate oxaloacetate 5-amino-6-(5-phospho- 7,8-dihydrofolate acetate 6-phosphate 1,2,3-tricarboxylate D-ribitylamino)uracil

a reduced plastocyanin a dicarboxylate a dicarboxylate a branched- an oxidized an amino an amino an inorganic an inorganic an inorganic an inorganic chain a nicotinamide queuosine ammonium acid acid arsenite plastocyanin D-gluconate anion anion anion mononucleotide anion a lipopolysaccharide a lipopolysaccharide amino acid a polysaccharide

RS10310 RS09075 RS05545 RS05790 RS06065 RS06545 RS00170 RS04025 RS07585 RS09705 RS05075 RS13305 RS01725 RS14195 RS06460 RS00530

a branched- D-gluconate an inorganic an inorganic an inorganic an inorganic a nicotinamide chain queuosine ammonium arsenite O anion anion anion anion a lipopolysaccharide a lipopolysaccharide mononucleotide a polysaccharide an amino an amino 2 amino acid H O acid acid 2 a dicarboxylate a dicarboxylate This diagram was automatically generated by SRI International Pathway Tools version 25.0, authors S. Paley and P.D. Karp.