Authors: Peter D. Karp Suzanne Paley Julio Collado-Vides John L Ingraham Ingrid Keseler Markus Krummenacker Cesar Bonavides-Martinez Robert Gunsalus An online version of this diagram is available at BioCyc.org. Biosynthetic pathways are positioned in the left of the cytoplasm, degradative pathways on the right, and reactions not assigned to any pathway are in the far right of the cytoplasm. Transporters and membrane proteins are shown on the membrane. Carol Fulcher Ian Paulsen Socorro Gama-Castro Robert LaRossa Periplasmic (where appropriate) and extracellular reactions and proteins may also be shown. Pathways are colored according to their cellular function. EcoCyc: Escherichia coli K-12 substr. MG1655 Cellular Overview Connections between pathways are omitted for legibility. Anamika Kothari Amanda Mackie Alberto Santos-Zavaleta succinate phosphate succinate N-acetyl-DL-methionine + L-ornithine glutathione + L-methionine S-oxide D-fructofuranose γ Ag+ molybdate ferroheme b L,L-homocystine asp lys cys L-alanyl- -D- D-mannopyranose 6-phosphate 2+ 2+ H D-methionine 2-deoxy-D-glucose succinate formate formate succinate D-tartrate putrescine agmatine cadaverine L-tartrate D-fructofuranose 6-phosphate + nitrate nitrate Cu thiosulfate deoxycholate L,L-homocystine D-cystine D-cycloserine methyl β-D-glucoside putrescine asp spermidine (S)-2-hydroxybutanoate (S)-2-hydroxybutanoate arg L-homoserine lactone magnesium hydrogenphosphate magnesium hydrogenphosphate antimonous acid glutamyl-meso- Co2+ Cd2+ lactulose poly-β-1,6- met cob(I)inamide 2,3-dioxo- D-glucosamine (2R,4S)-2-methyl-2,3,3,4- L-homoserine + H + sulfate phosphate D-cystine β FAD non-specific D-ala non-specific salicin methyl α-D-glucoside (2R,4S)-2-methyl-2,3,3,4- fumarate fumarate putrescine (S)-lactate (S)-lactate L-ornithine arg lys lys L-homoserine O-acetyl-L-serine O-acetyl-L-serine antimonous acid calcium hydrogenphosphate calcium hydrogenphosphate urea thr diaminopimelate L-glyceraldehyde 3-phosphate Cd2+ Zn2+ non-specific melibiose α ala N-acetyl-D- 4-hydroxybenzoate phosphate a 2,3,4- a 2,3,4- lanthionine 1-( -D glutathione enterobactin L-ascorbate [+ 4 more] glycolate asp fumarate CO2 CO2 citrate putrescine formate thr a polypeptide L-arabinose tyr succinate H 2+ methyl- -D-galactopyranoside nitrite nitrite Cu [+ 2 more] L-galactose β β cob(I)alamin L-cystine [+ 3 more] FMN ion/solute L-gulonate ala ion/solute pyridoxamine pyridoxine arbutin D-glucopyranose tetrahydroxytetrahydrofuran tetrahydroxytetrahydrofuran (S)-malate (S)-malate ser glycolate glycolate thr cys cys arsenite phosphate zinc hydrogenphosphate DL-glyceraldehyde D-glucopyranose 6-phosphate D-ribopyranose α-lactose α-lactose 2+ Mn Fe ion/solute α-lactose a lipopolysaccharide glucosamine N-acetyl- -D-glucosamine-1,6-anhydro-N-acetyl- -D-muramate shikimate cyanate saturated saturated a C4-dicarboxylate ammonium ribofuranosyl) (R)- asn 4-aminobutanoate a quaternary amine 2-oxoglutarate tellurite fumarate succinate succinate fumarate putrescine putrescine putrescine thr pyruvate L-canavanine sulfate lys cadaverine trp phe acetate ser ser pro glycine betaine Fe Mn2+ D-serine nitrite melibiose nitrite propanoate L-fucose a lyso-phosphatidylglycerol GlcNAc-1,6-anhMurNAc-L-Ala-γ-D-Glu-DAP-D-Ala fatty acid fatty acid S-sulfo-L-cysteine cytosine orotate nicotinamide [+ 3 more] pantothenate pro D-glucopyranose acetate fumarate fumarate (R)-lactate (R)-lactate arg trp arsenate [+ 3 more] [+ 3 more] succinate pro [+ 3 more] Fe [+ 2 more] melibionate D-arabinose a 2-acyl-1-lyso-phosphatidylethanolamine

L-methionine/ heme spermidine lysine / glutathione murein ATP synthase ATP synthase copper/ tripartite vitamin phosphate glutathione 2,3-diketo-L-+ L-ascorbate mannose- glucose- Autoinducer- putrescine putrescine arginine / / L-cysteine arabinose thiosulfate/ cytochrome D-methionine trafficking cystine ABC transport of pyridoxine preferential tripeptide ribose ABC / thiamin / thiamin silver efflux pump AmpG ShiA AaeAB B12 ABC NDH-1 ABC YjbB CynX FadD FadK TcyP CodB DctA AmtB PnuC ABC YeeO MscS gulonate:Na EntS CycA PanF MscL specific PTS AnsP GabP PPIII specific PTS BglF specific PTS KgtP ActP 2 ABC TqsA DcuA DauA DcuC DcuC DcuB FDH-O Fdh-N CitT ABC ABC PlaP PuuP DcuA DcuB PotE FocA TdcC LldP GlcA BtsT PotE ornithine ArgO AdiC CysZ CadB LysO LysP CadB RhtB RhtA TatABC EamB EamA ABC ABC TnaB AroP ArsB PitB PitA GlpF RhtC SatP TtdT UhpT SetB SetA SstT SdaC PutP ProP PntAB FeoB ZupT MntH FieF DsdX MscK NirC LacY MelB NarK NarK NarU AlaE PutP CopA sulfate ABC MsbA FucP LplT bo3 ubiquinol CbdAB PgaCD EmrKY-TolC ABC system transporter transporter transporter transporter symporter enzyme II pyridoxamine transporter enzyme II enzyme II transporter exporter transporter ABC ABC exporter transporter ABC transporter triphosphate triphosphate export transporter oxidase transporter CcmABCDE transporter transporter CydDC transporter synthase synthase system

YdeE 2+ + + β2 FAD non-specific non-specific (2R,4S)-2-methyl-2,3,3,4- L-homoserine lactone O-acetyl-L-serine O-acetyl-L-serine antimonous acid α-lactose α-lactose 2+ Cd2+ non-specific a lipopolysaccharide poly-UQHH O-1,6-2 4-hydroxybenzoate enterobactin formate L-homoserine a polypeptide H 2+ 2+ Cu cytochrome β β phosphate cytosine 1-(β-D FMN ion/solute ion/solute tetrahydroxytetrahydrofuran lys L-homoserine cys cys arsenite thr 2+ Zn2+ ion/solute methyl-α-D-galactopyranoside ala L-galactose N-acetyl-D- N-acetyl- -D-glucosamine-1,6-anhydro-N-acetyl- -D-muramate L,L-homocystine a C4-dicarboxylate D-cycloserine (R)- a quaternary amine methyl β-D-glucoside 6-phosphate glycolate asp succinate asp asp (S)-2-hydroxybutanoate (S)-2-hydroxybutanoate L-canavanine thr tyr magnesium hydrogenphosphate magnesium hydrogenphosphate antimonous acid acetate D-mannopyranose 6-phosphate glycine betaine Co2+ Mn lactulose + a lyso-phosphatidylglycerol 2 2 γ shikimate UQ NADH cyanate diphosphate diphosphate ammonium 4-aminobutanoate 2-oxoglutarate fumarate fumarate fumarate MQ MQ citrate putrescine putrescine putrescine ser pyruvate sulfate cadaverine thr succinate Fe Fe + nitrite nitrite nitrite nitrite propanoate UQH O glucosamine bd-I ubiquinol deoxycholate GlcNAc-1,6-anhMurNAc-L-Ala- -D-Glu-DAP-D-Ala D-cystine L,L-homocystine orotate ribofuranosyl) D-ala pantothenate asn pyridoxamine pyridoxine pro salicin 6-phosphate α tellurite succinate fumarate putrescine fumarate D-tartrate (S)-lactate (S)-lactate L-ornithine arg arg lys lys trp phe calcium hydrogenphosphate calcium hydrogenphosphate urea succinate D-fructofuranose 6-phosphate D-ribopyranose ser ser pro pro Cd2+ Fe D-serine melibiose melibiose Ag+ L-fucose a 2-acyl-1-lyso-phosphatidylethanolamine cob(I)inamide + 2,3-dioxo- L-ascorbate methyl -D-glucoside 6-phosphate (2R,4S)-2-methyl-2,3,3,4- thr 2 oxidase ferroheme b nicotinamide D-fructofuranose 6-phosphate acetate fumarate (S)-malate glutathione L-arabinose trp + H α melibionate molybdate D-arabinose UQH 2 NAD UQH2 L-cystine D-cystine glutathione ala arbutin-6-phosphate 2 MQH2 succinate putrescine fumarate spermidine glycolate glycolate putrescine agmatine phosphate zinc hydrogenphosphate DL-glyceraldehyde L-tartrate γ L-glyceraldehyde 3-phosphate Mn -lactose nitrate Cu O H2O 2 UQ N-acetyl-DL-methionine cob(I)alamin phosphate L-gulonate 6-phosphate 2-deoxy-D-glucose 6-phosphate D-glucopyranose 6-phosphate tetrahydroxytetrahydrofuran succinate MQH cadaverine cys L-alanyl- -D- H nitrate thiosulfate UQ O TorY L-methionine S-oxide S-sulfo-L-cysteine lanthionine [+ 3 more] D-glucopyranose 6-phosphate (S)-malate putrescine (R)-lactate (R)-lactate L-ornithine arsenate [+ 3 more] [+ 3 more] glutamyl-meso- D-glucopyranose 6-phosphate [+ 3 more] [+ 2 more] [+ 3 more] D-glucosamine 6-phosphate lys sulfate H2O UQ D-methionine [+ 4 more] diaminopimelate [+ 2 more] met succinate arg succinate 2'-deoxyuridine 3'- phosphate 2'-UMP α α α cellulose aminoacetone 2-phenylethylamine monophosphate a 1,4- -D-glucan , -trehalose YjbH YohC 2'UMP aminoacetone phenylethylamine 2'-deoxyuridine 3'- α-amylase: trehalase: treA Cofactor, Prosthetic Group, Electron Carrier, and Vitamin Biosynthesis Detoxification C1 Compound Utilization phosphatase: oxidase: tynA oxidase: tynA monophosphate malS β-D-glucopyranose α-D-glucopyranose superpathway of L-arginine Amino Acid Degradation and Assimilation N,N'- ChiP N,N'- L-lysine degradation I L-cysteine + α diacetylchitobiose diacetylchitobiose and L-ornithine degradation L-arginine degradation L-tryptophan α 5,6- CTP a [lipoyl-carrier a pyrimidine β UDP-N-acetyl- phoA methylglyoxal phenylacetaldehyde phosphatase: aphA maltohexaose a 1,4- -D-glucan biotin biosynthesis I degradation II II (AST pathway) nigerose cyanate -lactose formyl-CoA oxalate citrate dihydrothymine an acetyl ester an Fe(III)-siderophore NAD (R)-lipoate melibionate maltohexaose D-glucopyranose nucleoside N,N'-diacetylchitobiose 3-O- -D-galactopyranosyl-D-arabinose α-D-glucosamine N-acetyl-D-glucosamine superpathway of ubiquinol- superpathway of menaquinol-8 biosynthesis I superpathway of coenzyme A biosynthesis I (bacteria) superpathway of adenosylcobalamin salvage from cobinamide I superpathway of heme b biosynthesis from uroporphyrinogen-III Fermentation mixed acid fermentation degradation II superoxide protein]-L-lysine L-arginine uridine 2'-deoxyuridine MrdB 8 biosynthesis (prokaryotic) superpathway of tetrahydrofolate biosynthesis formaldehyde oxidation biotin ATP α ABC a cellodextrin guanylyl molybdenum cytidylyl molybdenum Secondary Metabolite Biosynthesis (via pyruvate) radicals arsenate nucleoside triphosphate -galactosidase: amylomaltase: ribosylpyrimidine chitin disaccharide galactoside-arabinose N-acetylglucosaminyltransferase: arg arg cofactor biosynthesis cofactor biosynthesis II (glutathione-dependent) cyanase: formyl-CoA citrate lyase: dihydropyrimidine acetylesterase: ferric chelate pyrophosphohydrolase: lipoate--protein melA deacetylase: chbG pgaD pgaC transporter demethylmenaquinol- arg lys degradation detoxification cynS β-galactosidase: transferase: citD citF citE dehydrogenase: aes reductase: nfeF ligase A: lplA malQ nucleosidase: rihB galactohydrolase: lacZ 8 biosynthesis I 3-methyl-2- a 5,10- cys arg biotin-ATP lacZ mazG a malonyl-[acp] MoO2- phosphoenolpyruvate II (glutaredoxin) frc preT preA 2+ α-D- β poly-β-1,6-N-acetyl- 2'-deoxycytidine chorismate oxobutanoate methylenetetrahydrofolate cob(II)inamide uroporphyrinogen-III lysine decarboxylase: ldcC trp ligase: birA a [lipoyl-carrier6 protein]- D-gluconate maltose maltopentaose D-ribofuranose a pyrimidine base N-acetyl- -D-glucosaminyl- D-arabinose β-D-galactopyranose UDP a UDP-sugar IPP MoO2- methylerythritol phosphate pathway I 2 ammonium oxaloacetate acetate an alcohol a siderophore Fe nicotinamide ADP-D-ribose galactopyranose acetate D-glucosamine 2'CMP chitin β GTP molybdopterin L-cysteine arginine N- superoxide formaldehyde biotinyl-5'- CO acetate CMP N -lipoyl-L-lysine (1->4)-D-glucosamine 3'-monophosphate ferroheme b a -D glucoside malonyl-CoA all-trans- molybdopterin autoinducer AI-2 biosynthesis I lysine decarboxylase: cadA oxalyl-CoA formate thymine UDP-sugar methyltransferase: 1,4-dihydroxy- cofactor desulfidase: succinyltransferase: tryptophanase: arsenate D-glucopyranose adenylate allolactose 2'CMP 2'-deoxycytidine 3'- β YqcE isochorismate octaprenyl cofactor 3-methyl-2-oxobutanoate cobinamide uroporphyrinogen pyruvate kinase: pykF arginine cadaverine cyuA astA superoxide deferrochelatase: -D-glucoside YfcP bioC isopentenyl- 2-naphthoate molybdenum cofactor molybdenum cofactor phosphoenolpyruvate 2 tnaA endochitinase: hydrolase: synthase: menF diphosphate hydroxymethyltransferase: adenosyltransferase: decarboxylase: hemE D-glyceraldehyde 3-phosphate pyruvate carboxylase: ppc decarboxylase, N -succinyl- dismutase: arsenate phosphatase: monophosphate glucohydrolase: bglX diphosphate ∆- guanylyltransferase: cytidylyltransferase: panB btuR pyruvate kinase: pykA degradative: adiA 2-aminoprop- sodB reductase: efeB 1,4-dihydroxy- GTP L-arginine S-(hydroxymethyl) chiA ushA 2+ a non glucosylated a malonyl-[acp] methyl ester isomerase: idi mobA mocA SAM 2-enoate H2O AqpZ H2O phoA phosphatase: aphA 2-naphthoate guanylyl cyclohydrolase cytidylyl L-cysteine arsC glutathione α Fe protoporphyrin IX D-glucopyranose isochorismate L-ornithine desulfhydrase: 6+ + + an -D-aldose D-glucose acceptor octaprenyltransferase: molybdenum I: folE molybdenum [corrinoid coproporphyrinogen III 1-deoxy-D-xylulose-5- a dipetide with an N- UDP-α-D-glucose cellulose a [protein] N-terminal- maltopentaose D-glucopyranose maltohexaose 2-O-(α-D-glucopyranosyl) β octyl α-D-glucopyranoside UDP-Galf cytidine UMP 2'-deoxycytidine 2-dehydropantoate tnaA N-succinylarginine superoxide arsenite glutathione D-allose Cr 8-oxo-GTP FAD NADH H trp terminal L-aspartate 5,6-dihydrouracil NAD(P)H FMN H hydroxylamine phenylacetyl-CoA H2O 1-( -D ribofuranosyl)nicotinamide a chitodextrin YlaC DMAPP menA cofactor cofactor asp adenosyltranferase]- phosphate synthase: dxs oxaloacetate pyruvate dismutase: AlsR formyl-L-methionine -D-glycerate 1-phosphate 7,8- cob(II)inamide agmatine dihydrolase: astB S-(hydroxymethyl) maltohexaose β YadM ornithine sodA glutathione chromate FAD dipeptidase: FMN cellulose hydroxylamine phenylacetyl-CoA peptide amylomaltase: glucosylglycerate nicotinamide riboside -1,6- demethylmenaquinol-8 dihydroneopterin 2 8-oxo-GTP- tryptophanase: dihydropyrimidine malQ glucosidase: malZ phosphorylase: xapA galactofuranosyltransferase: wbbI 2-succinyl-5- 3'-triphosphate 2-dehydropantoate coproporphyrinogen coproporphyrinogen III 1-deoxy-D-xylulose 5-phosphate SAH decarboxylase: L-cysteine hydrogen dehydrogenase: reductase: reductase: pepE reductase: fre synthase: reductase: hcp thioesterase: paaI deformylase: def phosphorylase: ycjM geranyl enolpyruvyl- 2-reductase: ilvC desulfhydrase: N -succinyl- diphosphatase: tnaA dehydrogenase: bcsB bcsA β aspartate 1- III oxidase: hemF dehydrogenase: hemN malate D-lactate agmatinase: speF L-ornithine 2-iminopropanoate peroxide frmA yieF fre + octyl -1,6-D-galactofuranosyl- thymidine 3'- an (S-diacyl-sn- a 3-oxoglutaryl- diphosphate 6-hydroxy-3- decarboxylase: preQ0 biosynthesis cysM mutT a proteinogenic preT preA an N-terminal L- maltose maltotetraose D-glucopyranose maltopentaose α-D-glucopyranose α nicotinamide UDP α a 2,3,4-saturated phosphoenol dehydrogenase: mdh dehydrogenase: ldhA speB 3+ + FMNH2 NAD(P) A H2O ammonium phenylacetate formate (R)-glycerate -D-ribose-1-phosphate -D-glucopyranoside H2O H2O H2O [acp] methyl ester synthase: ispA cyclohexene- dihydroneopterin panD 2-dehydropantoate arginine dependent pyruvate indole amino acid asp UDP cellulose methionyl-[protein] 1-phosphate D-allose DsbAoxidized cys monophosphate a phosphoglyceride glyceryl)-L-cysteinyl- 1-deoxy-D-xylulose S-adenosylhomocysteine pyruvate formate- AlsR-allose superoxide 2 fatty acyl CoA pyruvate YfeH 1-carboxylate triphosphate succinylornithine catalase: acid resistance Cr NAD FADH uracil D-allose ABC D-allose diphosphate 2'-deoxyribonucleoside apolipoprotein N- 2-reductase: panE [corrinoid 5-phosphate nucleosidase: mtn lyase: pflB L-cysteine adeD S-formylglutathione GSSG 8-oxo-GMP transporter acyl-CoA phosphoenolpyruvate [apolipoprotein] synthase: menD pyrophosphohydrolase: adenosyltranferase]- protoporphyrinogen IX protoporphyrinogen IX reductoisomerase: dxr malate superpathway of L-threonine metabolism transaminase: astC phosphatase: an N-acyl-(S-diacyl- YraH 3-oxo-glutaryl- geranyl nudB dehydrogenase, desulfhydrase: thioesterase: 3'-monophosphate phosphatase: phoA acyltransferase: lnt diphosphate β-alanine cob(I)inamide GTP pyruvate formate- (R)-lactate cysK 2 catalase: [acp] methyl ester (R)-pantoate NAD-requiring: maeA + phoA phosphatase: aphA sn-glyceryl)-L- a 1-lyso-phospholipid reductase: fabG protoporphyrinogen protoporphyrinogen lyase: tdcE N -succinyl- katG S-formylglutathione tesA pyruvate 2-succinyl-5-enolpyruvoyl- flavin biosynthesis I (bacteria and plants) S-ribosyl-L-homocysteine L-glutamate 5- pyruvate arg hydrolase: yeiG H a 2,3,4-saturated 7,8- cobinamide oxidase: hemG dehydrogenase: hemG MEP GTP DsbAreduced L-cystine thymidine cysteinyl-[lipoprotein] farnesyl 6-hydroxy-3-cyclohexene- dihydroneopterin thr L-cysteine semialdehyde aldehydo- hydrogen + a 2,3,4-saturated N-(2,3-dihydroxybenzoyl)- α an L-1- 3 HofO adenosyltransferase: cyclohydrolase catalase: arginine xylan 2 2 maltose maltohexaose a 1,4- -D-glucan a peptidoglycan glycerol fatty acid a (3R)-3-hydroxyglutaryl- diphosphate 1-carboxylate 3'-phosphate acetyl-CoA formate desulfhydrase: S-formylglutathione an aldehyde D-mannose 8-oxo-GDP a reduced hydrogen formate H O L-threo-3- A(H2) peroxide NAD NADPH fatty acyl CoA acetate a 9S rRNA L-serine trimer ferric complex phosphatidylethanolamine an N -methylcytosine in DNA 2-oxoglutarate molybdate pantothenate 2-carboxy-1,4- btuR I: folE (S)-malate katE decarboxylase, thioredoxin peroxide phenylserine sulfate/ [acp] methyl ester synthase: ispA superpathway of thiamine diphosphate biosynthesis I S-ribosylhomocysteine 7,8- putrescine malY hydrolase: frmB maltodextrin molybdate thiosulfate N-(2,3- N-(2,3- FimI synthetase: naphthoquinol biosynthesis 2-C-methyl-D- dihydroneopterin succinylglutamate degradative: adiA mannose α formate hydrogen:oxygen hydroperoxidase: pyridine nucleotide acetate CoA- ribonuclease: ferric chelate amylomaltase: lysozyme: phosphatidylglycerol N3-methylcytosine thiosulfate thiosulfate dihydroxybenzoyl) dihydroxybenzoyl) dihydroneopterin GTP panC lyase: luxS semialdehyde xylan - 8-oxo-GDP phenylserine malQ glucosidase: malZ rrrD ABC CirA (1R,6R)-2- erythritol 4-phosphate 3'-triphosphate O2 agmatine isomerase: xylosidase: dehydrogenase: oxidoreductase: katG transhydrogenase: transferase rne reductase: nfeF synthase: clsB demethylase: alkB sulfate sulfate -L-serine trimer -L-serine trimer (2E,6E)-farnesyl monophosphate adenosylcobinamide fumarase: fumE threonine L-cysteine dehydrogenase: formate diphosphatase: aldolase: ltaE transporter aldehydo-L- a 1-acyl-sn-glycero- γ-glutamyl-p- 3-hydroxyglutaryl- succinyl-6- cytidylyltransferase: ispD citrate synthase: gltA acetaldehyde formate L-threonine yihS yicI fdhF hyaC hyaB hyaA sthA 2+ a N-acetylmuramoyl- [+ 2 more] a sugar phosphate glutathione ferric complex ferric complex dephosphorylase phosphate dehydratase: mutT a 2,3,4-saturated N-(2,3-dihydroxybenzoyl) D-glucopyranose maltoheptaose D-glucopyranose a 1,4-α-D-glucan an L-1-phosphatidyl- [+ 2 more] oxidized glycyl-glycine [acp] methyl ester diphosphate fumarase: fumD dehydrogenase: adhE hydrogenlyase dehydrogenase: desulfhydrase: astD 2 N-acetyl-D- galactonate DsbA D-cysteine LdrA hydroxy-2,4- chorismate AI-2 6-carboxy-5,6,7,8- acetyltransferase: glutamate- putrescine an oxidized H O A + acetyl-CoA an rRNA fragment a 5S rRNA Fe pentapeptide- ethanolamine succinate formaldehyde a cytosine in DNA 3-phosphocholine nitroanilide dehydratase: fabZ cys complex: fdhF yiaY tdcB metC 2 fatty acid -L-serine trimer glucosamine sn-glycerol cyclohexadiene- protoporphyrin IX 4-(cytidine 5'-diphospho) tetrahydropterin putrescine aminotransferase: H O A(H2) CO2 H2O gly benzaldehyde NADP NADH diphosphoundecaprenol glutathione lysophospholipase: γ chorismate GTP cyclohydrolase (R)-pantothenate cobinamide fumarase A: fumA eutD hycE hycB hycG 2 keto-D-fructose α-D-xylopyranose 8-oxo-GMP thioredoxin phosphosugar -glutamyltranspeptidase: N-(2,3- N-(2,3- 1-carboxylate 7,8- II: ribA isochorismate kinase: cobU -2-C-methyl-D-erythritol synthase: queD citrate ligase: puuA patA 2-aminoprop- N - a carboxylate L-galactono- chorismate all-trans- synthase: menH dihydroneopterin synthase: menF fumarase B: fumB hycF hycC hycD threonine 2-enoate phosphatase: hydrolase: ggt tesA ggt dihydroxybenzoyl) Fiu dihydroxybenzoyl)ElfG an enoylglutaryl- octaprenyl- threonine threonine succinylglutamate γ-lactonase γ -L-serine trimer L-cysteine:[protein ferrochelatase: phosphate acetaldehyde aldolase: deaminase: sn-glycero-3- -L-glutamyl- -L-serine trimer [acp] methyl ester diphosphate 2,5-diamino-6-(5-phospho-D- pantothenate isochorismate 4-(cytidine 5'- 6-carboxy-5,6,7,8- fumarase C: fumC acetyltransferase: pta dehydrogenase: ltaE phoA glu L-cysteinylglycine a carboxylate 4-nitroaniline ferric complex ferric complex cysteine] 4-amino-4- adenosyl-cobinamide 5,6-dimethylbenzimidazole hemH diphospho)-2-C-methyl- citrate hydro- ilvA reduced phosphocholine glycylglycine chorismate synthase: ispB (1R,6R)-6-hydroxy-2- dihydroneopterin deoxychorismate ribosylamino)pyrimidin-4(3H)-one kinase: coaA tetrahydropterin γ-glutamyl- tdh succinylglutamate Polymeric Compound L-galactono- DsbA D-cystine YciC sulfurtransferase: phosphate D-erythritol kinase: ispE lyase: acnB 2 2 4-aminobutanal a sugar lyase: ubiC aldolase: folB (2R,4S)-2-methyl-2,4- fumarate alcohol CO H L-putrescine 2-amino-3- desuccinylase: astE Degradation β 1 enoylglutaryl- succinylcyclohexa-2,4- iscS synthase: α D-glucosamine N-acetyl- - Tyr (4S)-4-hydroxy- 1-(6-sulfo-α- hydrogen maltoheptaose RNase III mRNA 1,4-lactone diene-1-carboxylate pabB pabA polyisoprenoid biosynthesis (E. coli) ferroheme b dihydroxydihydrofuran-3-one dehydrogenase: adhE ketobutyrate an aryl sulfate a 1,4- -D-glucan diacetyl β-D-glucose pyruvate acetaldehyde neuraminate 1-butanesulfonate asp fumarate menadiol glutathionylspermidine [DNA] an N -ethyladenine in DNA 2-oxoglutarate [acp] methyl ester all-trans- diaminohydroxyphosphoribosylaminopyrimidine (R)-4'- nicotinate- 2-phospho-4-(cytidine 5'- UhpC D-tyrosyl-tRNA 2-oxoglutarate D-quinovosyl) peroxide processing substrate S-methyl-L- S-methyl-L- reductase: fabI octaprenyl 6-(hydroxymethyl) 2-succinyl-5- cobinamide-P acetyl phosphate γ-glutamylputrescine CoA ligase: kbl (2Z)-2-aminobut- muropeptide degradation 6-phosphate glycerol MmuP YgiL 4-hydroxybenzoate deaminase: ribD phosphopantothenate enolpyruvyl- nucleotide--dimethylbenzimidazole diphospho)-2-C-methyl-D-erythritol cis-aconitate L-2-amino-3- 2-iminopropanoate succinate glu N-acetyl-β- Tyr maltoheptaose glutathionylspermidine exodeoxyribonuclease 1-ethyladenine methionine methionine diphosphate L-cysteine -7,8-dihydropterin 4-amino-4- guanylyltransferase: fumarate reductase: ethanol oxidase: puuB gly acetaldehyde 2-enoate predicted acetoin acetoin alkanesulfonate 2-keto-4- menadiol:hydrogen endoribonuclease: rnc o-succinylbenzoate 6-hydroxy-3- cobU phosphoribosyltransferase: cobT frdA frdB frdC frdD dehydrogenase: adhP oxobutanoate α-amylase: glucosamine synthesis: neuraminate D-Tyr-tRNA monooxygenase: hydroxyglutarate L-aspartate sulfoquinovosidase: peroxide glucosidase: malZ amidase: gss III: xthA demethylase: alkB uridine 2'3'-cyclic synthase: menC desulfurase: deoxychorismate cyclohexene- 7-carboxy-7- amyA kinase: glk dehydrogenase: lyase: nanA deacylase: dtd oxidase: nadB yihQ + an L-1- YmfR a glutaryl-[acp] methyl ester sufS 5-amino-6-(5-phospho- phosphopantothenoylcysteine IPP 2-C-methyl-D-erythritol γ poxB ssuD aldolase: eda oxidoreductase: ccp a 2'- Cu phosphocholine an aldose glutathione glycyl-glycine 2-amino-4-hydroxy-6- 1-carboxylate deazaguanine D-threo-isocitrate acetate kinase: ackA 4-(γ-L- L-alanyl- -D-glutamyl-meso- yohF Tyr 6-sulfo-D- D-glucopyranose maltohexaose RNase III processing monophosphate hydroxymethyldihydropteridine D-ribosylamino)uracil synthetase: dfp adenosylcobinamide- 2,4-cyclodiphosphate ethanol 1-pyrroline acetaldehyde L-glutamine 2,6-diaminopimeloyl-D-alanine succinate glycerol spermidine glutathione deoxyribonucleoside [DNA] an mRNA fragment succinate acetaldehyde an adenine in DNA phosphatidylethanolamine 4-hydroxybenzoate synthase: menD α-ribazole 5'-phosphate (2R,4S)-2-methyl-2,3,3,4- succinate hydro-lyase: acnB glutamylamino) N-acetyl-β-D- D-tyrosine a tRNA 2-iminosuccinate quinovose product mRNA uridine 2'3'-cyclic phospholipase γ an [L-cysteine diphosphokinase: folK aminodeoxychorismate GDP synthase: ispF butanal dehydrogenase degradation I α D-glucosamine UhpC-glucose-6-P acetoin pyruvate sulfite butan-1-al pyruvate glyoxylate H2O menadione 5'-monophosphate cuprous phosphocholine -glutamyltranspeptidase: octaprenyltransferase: 2-succinylbenzoate isopentenyl- tetrahydroxytetrahydrofuran 7-cyano-7- L,D- a 1,4- -D-glucan acetoin mannosamine aldose sugar 3-oxo-pimeloyl- desulfurase]-S- lyase: pabC 5-amino-6-(5- (R)-4'- (acetylating) carboxypeptidase: a phenol 6-phosphate phosphodiesterase: A2: pldA ggt YejO ubiA phosphoribosylamino) diphosphate ∆- deazaguanine acetate : mhpF pyruvate oxidase: phosphatase: dehydrogenase: yliI [acp] methyl ester sulfanyl-L-cysteine a ThiS sulfur- (7,8-dihydropterin- phosphopantothenoyl- 2-succinyl-5-enolpyruvoyl- D-threo-isocitrate Pentose Phosphate Pathways γ γ 2-iminobutanoate ldcA cpdB a 1-acyl,2-lyso- γ-L-glutamyl- synthase: fabB o-succinylbenzoate--CoA carrier protein uracil reductase: ribD L-cysteine isomerase: idi 2-C-methyl-D-erythritol- synthase: queC -glutamyl- - cueO phoA a fatty acid L-cysteinylglycine WbbH 6-yl)methyl 4-aminobenzoate 6-hydroxy-3-cyclohexene- 2,4-cyclodiphosphate aminobutyraldehyde aminoacetone gln L-alanyl-γ-D-glutamyl- phosphatidylethanolamine glycylglycine ligase: menE diphosphate cobalamin 5'- 2+ 3'-UMP cysteine :[Thil sulfur- 1-carboxylate dehydrogenase: puuC acetaldehyde L-serine glutaminase: asnB meso-diaminopimelate an aldonate 3-octaprenyl-4- phosphate isocitrate aminobutyraldehyde β 6 1 Cu choline a 3-oxopimeloyl- protein cysteine] ThiS 5-amino-6-(5-phospho- 4'-phosphopantothenoylcysteine DMAPP preQ0 pentose phosphate pathway dehydrogenase: degradation D-galactono- (3R)-3,4- poly- -1,6-N-acetyl- 3-hydroxybenzoyl- maltopentaose hydroxybenzoate D-ribitylamino)uracil decarboxylase: dfp synthase: superpathway of pyridoxal 5'-phosphate biosynthesis and salvage 1-hydroxy-2-methyl-2-(E dehydrogenase: icd γ dehydrogenase: puuC glutaminase: glsA dodecyl sulfate glycerol 1- pyridoxine D-mannopyranose a uracil in DNA acetyl-CoA oxalate bromoacetate glutathione D-glucosamine H2O a carboxylic ester glycerophosphoserine 1,N -ethenoadenine in DNA 2-oxoglutarate an N -methyladenine in DNA 2-oxoglutarate a tripeptide DtpB a tripeptide [acp] methyl ester 4-(2'-carboxyphenyl) sulfurtransferase: adenylyltransferase: cobS 4-( -L- adhE 1,4-lactone phosphate AceF (R)-lipoate dihydroxybutanal DsbBoxidized DsbAreduced CoA a dipeptide a dipeptide -4-oxobutyryl-CoA iscS dihydropteroate (1R,6R)-2- )-butenyl 4-diphosphate glutamylamino) murein tripeptide 6 3-octaprenyl-4- thiF synthase: ispG γ-aminobutyraldehyde glutaminase: glsB amidase: mpaA maltopentaose carboxylesterase: yjfP 1,N -ethenoadenine ElfA synthase: folP succinyl-6- D-glucopyranose butanoate pyridoxine 4- D-3,4- uracil-DNA acetyl- bromoacetate 3-hydroxybenzoyl- glycerophosphoserine N1-methyladenine AaeX 3-oxo-pimeloyl- hydroxybenzoate 5-amino-6-(5- 4'-phosphopantetheine hydroxy-2,4- geranyl 2-oxoglutarate 6-phosphate dehydrogenase: patD 2-oxobutanoate ser D- glycerol-3- lipoate-AceF CoA:oxalate CoA- CoA glucosidase: malZ phosphodiesterase: ugpQ repair: alkB demethylase: alkB cytidine 2',3'-cyclic 1,4-dihydroxy-2- phospho-D- diphosphate D-erythrose acetyl-CoA galactono- dehydrogenase: mannokinase ligase: lplA dihydroxybutanal glycosylase: dehalogenase: carboxylesterase: bioH D-gluconate an L-1- an L-1- core oligosaccharide-lipid [acp] methyl ester decarboxylase: ubiD a [ThiI sulfur- a carboxy- cyclohexadiene- 4-phosphate γ-glutamyl-γ- methylglyoxal imidazole glycerol phosphatase: ung transferase: yfdE gstB partially deacetylated thioesterase: entH an aliphatic amine partially partially naphthoyl-CoA ribitylamino)uracil synthase: ispA adenosylcobalamin (E)-4-hydroxy-3-methylbut- phosphate L-alanyl-D-glutamate γ-lactonase pdxI reductase: yqhD D-glucopyranose maltotetraose DsbDreduced DsbCoxidized monophosphate reductase: fabG carrier protein]- adenylated- D-ribulose 5-phosphate 1-carboxylate + aminobutyrate serine hxpA β an alcohol sn-glycerol glyoxal succinate formaldehyde an adenine in DNA 6-phosphate phosphatidylethanolamine phosphatidylethanolamine A (E. coli K-12 core type) deacetylated deacetylated synthase: menB S-sulfanyl- [ThiS sulfur- 7,8- phosphatase: yigB 5'-phosphate 2-en-1-yl diphosphate synthase: hisH hisF an apyrimidinic S-(acet-2-yl) acetate poly- -1,6-N-acetyl- a carboxylate ser succinate an adenine in DNA cytidine 2'3'-cyclic β β (2E,6E)-farnesyl diphosphate pantetheine- synthase: menH Aromatic Compound Biosynthesis NADP -dependent hydrolase: puuD deaminase: D-mannopyranose AceF-lipoate DsbBreduced DsbAoxidized uracil acetate D-glucosamine 3-phosphate gluconate 6- phospholipase poly- -1,6- PgaA poly- -1,6- L-cysteine carrier protein] dihydropteroate D-erythrose- acetohydroxybutanoate tdcG D-galactonate 1,3,4-butanetriol site in DNA oxalyl-CoA bromide -glutathione 3-hydroxybenzoate amine N-acetyl-D- 2-octaprenylphenol phosphate geranyl glucose-6- 2-ketobutyrate 1-dodecanol glycerol pyridoxal 6-phosphate phosphate phosphodiesterase: N-acetyl-D- a (3R)-3-hydroxypimeloyl- 1,4-dihydroxy-2- diphosphate 4-phosphate formate- synthase: ilvG ilvM L-Ala-D/L-Glu oxidase: A1: pldA glucosamine glucosamineYdeQ [acp] methyl ester 3,4-dihydroxy- adenylyltransferase: adenosylcobalamin phosphate epimerase: ycjG a 2-acyl-1-lyso- lipid A-core- HokB naphthoyl-CoA dihydrofolate 5-amino-6-(5- coaD (1R,6R)-6-hydroxy-2- dehydrogenase: isopentenyl- enterobactin biosynthesis dehydrogenase: lyase: pflB xanthosine-5'- phosphatase: cpdB 2-octaprenylphenol all-trans- 2-butanone- phospho-D- succinylcyclohexa-2,4- 5'-phosphate epd superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass acetohydroxybutanoate L-serine phosphate:L- tynA a fatty acid a 1,2-diacyl-sn-glycerol D-glyceraldehyde synthetase: folC diphosphate:NAD(P)+ zwf reduced oxidized phosphatidylethanolamine phosphoethanolamine (hep I) hydroxylase: ubiI octaprenyl- adenylate:persulfide 4-phosphate ribitylamino)uracil diene-1-carboxylate farnesyl phosphatase: cobC dimethylallyl- proline degradation synthase: ilvI ilvH deaminase: glutamine amido- a tripeptide phoA DsbC DsbD 3'-cmp 3-hydroxypimeloyl- 1,4-dihydroxy-2- 3-phosphate transferase: thiF synthase: ribB oxidoreductase: ispH D-serine 747 6 a tripeptide diphosphate phosphatase: ybjI 3'-dephospho- diphosphate diphosphate:NAD(P)+ 2-ketobutyrate sdaA ligase (AMP- L-alanyl-L-glutamate + α α DtpC an aldehyde [acp] methyl ester naphthoyl-CoA degradation an aliphatic a dipeptide with β a uracil -Kdo-(2->4)- - CMP-Kdo a [protein]-N - a [50S ribosomal subunit81 a dipeptide a dipeptide D-gluconate synthase: ispB 7,8-dihydrofolate 4-phospho- L-idonate a -D-galactoside NADH H A kojibiose 3-(all-trans hydrolase: menI CoA synthase: ispA oxidoreductase: ispH chorismate D-glucopyranose 6-phosphate 6-phospho formate- forming): guaA heme b GSSG riboflavin α,ω-diamine SucB (R)-lipoate proline at the C-terminal a RNA-DNA hybrid in 23S rRNA isethionate menadione nitrite Kdo-(2->6)-lipid IV monoubiquitinyl-L-lysine protein L16]-L-arginine 2-oxoglutarate 5-amino-6-(5-phospho-D-ribosylamino)uracil dehydratase: fabZ monoglutamate o-succinylbenzoate adenosylcobalamin D-erythronate D-glucono- lyase: tdcE -octaprenyl) 1-deoxy-D- carboxy-adenylated- 1-deoxy-L-glycero- synthase: menC (S)-2-aceto-2- serine alanylglutamate RNase: rnhB 5 Kdo transferase: YadN CsgD benzene-1,2-diol [ThiS sulfur- tyr ARP dephospho- isopentenyl-diphosphate 1,5-lactone pro hydroxybutanoate deaminase: L-idonate 5- Xaa-Pro galactoside O- isethionate NADH nitrite reductase - deubiquitinase: kojibiose protein-arginine 5-amino-6-(D-ribitylamino) all-trans-octaprenyl xylulose-5- tetrulose 4-phosphate (2E,6E)-farnesyl ∆ IPP D-serine [+ 3 isozymes] dipeptidase: pepD heme d glutathione riboflavin diamine lipoate-SucB dipeptidase: 23S rRNA m U747 waaZ elaD phosphorylase: oxygenase: roxA uracil glycosidase: ybiA an enoylpimeloyl- diphosphate 1,4-dihydroxy-2-naphthoate phosphate carrier-protein] CoA kinase: diphosphate erythronate- -isomerase: idi isochorismate glucose-6-phosphate 4-aminobutanoate tdcB synthase: reductase: reductase: transaminase: dehydrogenase: ribonuclease: acetyltransferase: monooxygenase: dehydrogenase NADH dependent: β [acp] methyl ester 2-octaprenyl-6- synthase: entC proline glu ligase: lplA pepQ methyltransferase: ssuD (quinone) nirD nirB α-Kdo-(2->4)-α-Kdo-(2-> ycjT a phosphate N-acetyl-9-O- -D-glucosyl-1- synthase: sulfurtransferase: thiI coaE 2-succinylbenzoate 4-phosphate isomerase: pgi 6-phosphogluconolactonase: katE gor fre patA idnD rnhA lacA rlmC CMP a [ubiquitin] C- a [50S ribosomal subunit protein81 FMN 2-phosphoglycolate a lipopolysaccharide propanoyl-CoA + α A D-ribofuranose 5-phosphate DsbGoxidized DsbDreduced hydroxyphenol dxs dehydrogenase: pgl dehydrogenase: D-serine (R)-2,3-dihydroxy-3- ala glu + + 4)- -Kdo-(2->6)-lipid IV a [protein]-L-lysine succinate 5,6-diaminouracil monoester acetylneuraminate phosphoundecaprenol 2-iminoacetate DMAPP 4-aminobutyrate putA methylpentanoate:NADP L-serine SucB-lipoate a proteinogenic a nucleoside 5'- β 747 terminal glycine β-D-glucopyranose L16]-(3R)-3-hydroxy-L-arginine 6,7-dimethyl-8- pdxB ammonia- ω pro DNA a 6-acetyl- - sulfite glycolaldehyde NAD menadiol NAD H2O ammonium D-glucopyranose N-acetyl-9-O- enoylpimeloyl- methylase: ubiG synthase: thiH a 7,8-dihydrofolate coenzyme A isochorismate F6P aminotransferase: (S)-1-pyrroline- lyase: oxidoreductase deaminase: heme d glutathione reduced riboflavin an aliphatic - 5-dehydro- amino acid monophosphate D-galactoside a 5-methyluracil 1-phosphate FMN alkaline YdgU 1,4-dihydroxy- ribityllumazine o-succinylbenzoate--CoA all-trans- [EntB aryl- D-gluconate puuE aminoaldehyde D-gluconate in 23S rRNA YibH 2-phosphoglycerate [acp] methyl ester 1-deoxy-D- synthase: ribE ligase: menE di-trans,poly-cis-decaprenyl 5-carboxylate dsdA phosphate (isomerizing): ilvC sdaB glycine cleavage phosphatase: acetylneuraminate YqiI reductase: fabI 2-methoxy- 2-naphthoate a thiocarboxy- diphosphate:isopentenyl- octaprenyl- (3R)-3-hydroxy-2-oxo- carrier protein] 6-phosphate propionyltransferase: pta phosphatase: phosphatase: phoA α 6-(all-trans- xylulose 5- 2-aminoprop- esterase: nanS di-trans,octa-cis- an -D-glucosyl- octaprenyltransferase: phosphate [ThiS-Protein] 2-iminoacetate dihydrofolate diphosphate diphosphate 4 phosphooxybutanoate isochorismatase: fructose-1,6- 2-aminoprop- 2-enoate phoA phoA octaprenyl)phenol menA reductase: folM 4-(2'-carboxyphenyl) undecaprenylcistransferase: ispU synthase: ispB phosphopantetheinyl entB ser bisphosphatase: yggF 4-aminobutyrate 2-enoate (R)-2,3-dihydroxy- DsbDoxidized DsbG acetate N-acetylneuraminate undecaprenyl phosphate lipopolysaccharide AIR 6-phosphogluconate transaminase: propanoyl 3-methylpentanoate a [glycine- α 2457 a pimeloyl-[acp] methyl ester -4-oxobutyryl-CoA transferase: entD dehydrogenase, N-acetyl- - uridine 2-dehydro-3-deoxy- 3-(N-morpholino) an 6-sulfo-α- a 10- a 1-palmitoyl-2-acyl-sn- 3,4-dihydroxyphenylacetyl- riboflavin an alcohol glycolate 6,7-dimethyl-8-(1-D-ribityl)lumazine phosphohydroxythreonine gabT cleavage complex6 thiamine L-idonate L-cysteine lipid A quercetin thiamin(e) 2-octaprenyl-6- dihydrofolate aminotransferase: serC fructose 1,6- 6-phosphofructokinase: phosphate L-idarate (S)-NADPHX 8-oxo-dGTP trimethylamine TorT cys an arylamine neuraminate in 23S rRNA L-rhamnonate propanesulfonate L-carnitine D-quinovosyl formyltetrahydrofolate glycero-3-phosphocholine CoA ProY methoxyphenol reductase: folA (2S,3S)-2,3-dihydroxy- decarboxylating: gnd H protein] N - N-oxide desulfurase diacylglycerol thiamine ABC thiamine phosphomethylpyrimidine 1-deoxy-D-xylulose molybdenum cofactor biosynthesis 1,4-dihydroxy-2- di-trans,octa-cis all-trans- 2,3-dihydrobenzoate enterobactin bisphosphatase: ybhA pfkA L-glutamate-5- 2,3-dihydroxy-3- lipoyl-L-lysine transporter YfaL hydroxylase: ubiH glycine 2-keto-3-deoxy- alkanesulfonate carnitine formyltetrahydrofolate Lipid IVA hydroxyphenylacetyl- quercetin 2,3- pimeloyl-[acp] demethylmenaquinol-8 5-phosphate:thiol naphthoyl-CoA octaprenyl holo-[acyl- succinate propionate methylvalerate thiamine L-idarate (S)-NADPHX 8-oxo-dGTP L-idonate 5- cysteine arylamine N- 23S rRNA 2457 sulfoquinovosidase: methyl ester synthase: thiC riboflavin -undecaprenyl 4-phosphooxy- carrier- synthase: D-ribulose semialdehyde semialdehyde decarboxylase: N-acetylneuraminate L-rhamnonate monooxygenase: monooxygenase: deformylase: purU palmitoyltransferase: CoA thioesterase: paaI dioxygenase: yhhW sulfurtransferase: a tetrahydrofolate synthase: ribC synthase: menB diphosphate diphosphate D-glyceraldehyde entB entD fructose-1,6- 6-phosphofructokinase: 5-phosphate kinase: ackA hydro-lyase: ilvD 2-iminopropanoate gcvP kinase: epimerase: dehydratase: diphosphatase: dehydrogenase: desulfurase: acetyltransferase: mutarotase: nanM pseudouridine aldolase: yfaU yihQ D-mannose α a [protein] with α α esterase: bioH 2-methoxy-6-all thiG tetrapyrrole biosynthesis 3-phosphate pyruvate L-threonine protein] 2,3-dihydro-2,3- bisphosphatase: glpX pfkB 2-iminopropanoate thiK idnD ssuD yeaX yeaW pagP -D-mannose a 1-acyl,2-lyso- an L-1- -Kdo-(2->4)- - trans-octaprenyl- I (from glutamate) dihydroxybenzoate [EntF L-seryl- entF entE H-Gcv-protein- gudD nnr mutT iscS nhoA synthase: rluE 6-sulfo-D- S-adenosylmethionine:2- cys synthase: carrier protein] γ propionate a 1,2-diglyceride formate a tetrahydrofolate coenzyme A 3,4-dihydroxyphenylacetate CO 2-protocatechuoylphloroglucinolcarboxylate 6-phosphate 1-phosphate triphosphate an N-terminal phosphatidylethanolamine phosphatidylethanolamine Kdo-(2->6)-lipid IVA 1,4-benzoquinol demethylquinol-8 HMP-P 1,4-dihydroxy-2- undecaprenyl acpS dehydrogenase: entA succinate- L-glutamate - (S)-3-methyl-2- (dihydrolipoyl) TorT-TMAO an S-sulfanyl- β 2457 3-(N-morpholino) L-malic quinovose a 2-acyl-sn-glycero- lipid B (E. coli) YeiS riboflavin fructose-1,6- + kinase: tdcD 5-dehydro- N-acetyl- - (S)-lactaldehyde pyruvate sulfite trimethylamine mannose 6- mannose 1- 1-acyl- a pimeloyl-[acp] methyltransferase: ubiE naphthoyl-CoA pyrophosphate 4-hydroxythreonine- semialdehyde semialdehyde oxopentanoate lysine:NAD+ thiamine D-glucarate 8-oxo-dGMP ala [L-cysteine an N- neuraminate a pseudouridine propanal semialdehyde 3-phosphocholine triphosphate L-arginine alkaline 1-deoxy-D- 4-phosphate L-serine-- bisphosphatase: fbp ribulose- ribose-5- NADP -dependent dehydrogenase: oxidoreductase: lpd phosphate NADPH D-gluconate desulfurase] acetylarylamine in 23S rRNA YjbE 2-octaprenyl- phosphomethylpyrimidine glu phosphatase: xylulose-5- dehydrogenase: phosphopantetheinyl phosphate 3- dehydrogenase+ succinate- phosphate phosphate phosphatase: phosphatase lysophospholipase: 2-[(2R,5Z)- L-cysteine:[protein 1,4-dihydroxy-2- pgpB 2,3-dihydroxybenzoate [holo EntF] phosphate (NAD ): puuC putA propanoate isoleucine a tripeptide a tripeptide 7-O-[2-aminoethoxy(hydroxy) 6-methoxy-1,4- kinase: thiD 2-carboxy-4- ATP phosphate pdxA transferase: entD ligase: entF epimerase: isomerase semialdehyde DtpA phosphatase: phosphatase: phoA pldA benzoquinone menaquinol-8 riboflavin kinase: ribF cysteine] naphthoyl-CoA synthase: dxs holo-[acyl β-D-fructose 1,6-bisphosphate dehydrogenase: transaminase: a [glycine- a dipeptide a dipeptide aminopeptidase: iap sn-glycero-3- phosphoryl]-α-D-Kdo-(2->4) a 1,2-diacyl-sn-glycerol 8-amino-7- methylthiazol-5(2H glutamate--tRNA NAD de novo biosynthesis rpe A: rpiA pyruvate a [glycine-cleavage 6 sulfurtransferase: hydrolase: menI carrier fructose-bisphosphate pyruvate L-alanine degradation I ilvE cleavage complex6 phoA phoA a carboxylate oxononanoate methylase: ubiE )-ylidene]ethyl ligase: gltX gabD 2604 diphosphate phosphate a peptide arg α A I (from aspartate) iscS GTP protein] 2,3- aldolase: fbaB glu complex H protein] N - 2+ β phosphoethanolamine - -D-Kdo-(2->6)-lipid IV PspD synthase: bioF HMP-PP phosphate undecaprenyl 3-amino-1- a holo-[EntF L- succinate H protein] N - aminomethyldihydrolipoyl- lysine within a uridine a dimer of an N-acetyl- - a 2-acyl-1-lyso- D-mannose D-mannose an L-glutamyl-Glu synthase: dihydroxybenzoate- (L-seryl)adenylate 8-oxo-dGDP phosphoenol (R)-lipoate 3-ureidoacrylate γ a ribonucleic acid α di-trans,octa-cis- glycerophosphoglycerol FMN molybdopterin- pyrophosphate 1-deoxy-D-xylulose hydroxyacetone seryl-carrier protein] DHAP semialdehyde dihydrolipoyl- L-lysine Cu (R)-NADHX L-tartrate PtsH L-selenocysteine isovaleryl-CoA aminoacetone gcv protein H in 23S rRNA 2-oxoglutarate SucB-lipoate -butyrobetaine non-adjacent hν D-hexosaminide UDP- -D-glucose phosphatidylethanolamine 6-methoxy-3- [tRNA ] 1,4-dihydroxy-2-naphthoate phosphatase: 5-phosphate 1-phosphate acpT [aryl-carrier fructose bisphosphate ribose-5- L-lysine pyruvate undecaprenyl phosphate YpjA synthase protein] ligase: entE D-xylulose dehydrogenase,+ ile thymidines in DNA β 8-amino-7-oxononanoate methyl-2-all- asp L-cysteine adenylyltransferase: ybjG triose-phosphate aldolase: fbaA 5-phosphate phosphate ala lipoate-apo- ureidoacrylate γ-butyrobetaine endoribonuclease -N- acyltransferase: trans-octaprenyl- desulfurase: pyridoxine isomerase: NAD - NADH NADHX L(+)-tartrate 8-oxo-dGDP selenocysteine isovaleryl-CoA D-aminopropanol 23S rRNA 2604 deoxyribodipyrimidine acetylglucosaminidase: bactoprenyl glucosyl FMN moeB GTP 3',8'- 10 dependent: sad GcvH protein amidohydrolase: monooxygenase: toxin ChpB: chpB pldB 1,4-benzoquinol thiamine sufS cyclase: moaA isomerase: tpiA rpiB alanine cupric epimerase: dehydratase: diphosphatase: lyase: sufS dehydrogenase: dehydrogenase: pseudouridine photolyase: phr nagZ transferase: yfdH D-glucosamine a peptidyl- a 2-acyl-1-lyso- core adenosylcobalamin glutamyl- L-aspartate adenylyltransferase: N -formyl-tetrahydrofolate biosynthesis a holo-[EntB aryl- (2,3-dihydroxybenzoyl) reductase: ligase: lplA rutB yeaX yeaW a 5'-hydroxy- an [RNA]-3'- trimethylamine a reduced Mdl phosphate tRNA ribF pyridoxine 5'- pyridoxine pyridoxamine carrier protein] enterobactin racemase: dadX L-glutamate nnr ttdA ttdB mutT aidB gldA synthase: rluF SucB-S- β-D-glucosyl-1- a lyso- sn-glycero-3- a primary amine an L-1- oligosaccharide- 7,8- salvage from cobalamin oxidase: nadB undecaprenyl adenylate ndh his15 ribonucleotide- ribonucleoside- UDP 6-phosphate dipeptidase phosphatidylethanolamine synthase: an [L-cysteine a carboxy-adenylated phosphate kinase: pdxK synthase: a [glycine-cleavage 2604 succinate a thymidine in DNA an N-acetyl-β- phosphoundecaprenol phospholipid phosphoethanolamine N-oxide TorC protein diaminopelargonic tetrahydromonapterin reductase: (8S)-3',8-cyclo-7,8- pyrophosphate entB entD alanine racemase: alr degradation IX (via aminomethyltransferase: HPr-P pyruvate selenide ala succinyldihydrolipoate aminoacrylate carbamate trimethylamine 3'-[RNA] 3'-phosphate an alcohol primary glucosamine 2-acyl- lipid A (E. coli thiE 2-iminosuccinate desulfurase]-S- [small subunit of synthase: pdxJ L-asparagine + 3-methylcrotonyl- (R)-1- complex6 H protein] a pseudouridine semialdehyde D-hexosamine Dcp substratepeptidyl- trimethylamine phosphatidylethanolamine acid synthase: bioA 2-octaprenyl- biosynthesis hemA dihydroguanosine phosphatase: pyridoxamine entF entE succinate 4-aminobutanoate) gcvT (S)-NADHX oxaloacetate 8-oxo-dGMP HlyE FAD sulfanyl-L-cysteine molybdopterin synthase] a tetrahydrofolate D-ribose 5- degradation I D-ala Cu CoA aminopropan-2-ol N -lipoyl-L-lysine in 23S rRNA a dipeptide DtpD a dipeptide amine 6-phosphate lysophospholipase: K-12 core type) vitamin 3-methyl-6- cob(I)alamin 5'-triphosphate bacA kinase: pdxK D-glyceraldehyde 3-phosphate phosphate dipeptidase: N-oxide B12 outer methoxy-1,4- (S)-4-amino-5- quinolinate 2,3- oxidase: phosphatase: pldA cob(I)inamidecob(I)inamide 7,8-diaminopelargonate benzoquinol pyridoxal dihydroxybenzoate- glu dcp reductase: torA sn-glycero-3- lipid A-core- a 1,2-diacyl- membrane thiamine oxopentanoate synthase: cyclic pyranopterin di-trans,octa-cis L-serine-- transketolase: tynA phoA an oxidized a carboxylate cob(I)alamin cob(I)alamin transport hydroxylase: GTP nadA monophosphate -undecaprenyl pyridoxine 5'-phosphate pyridoxamine [aryl-carrier [holo EntF] glyceraldehyde- asn D-alanine:quinone a dipeptide a peptide trimethylamine pyrophosphoethanolamine ubiF phosphate pyridoxal 5'-phosphate protein] ligase: entE tktB oxidoreductase glutamate 2605 TorC protein phosphoethanolamine sn-glycerol complex synthase: moaC phosphate ligase: entF 3-phosphate asparaginase: thymine ethyl-2- cyclic 2-methyl-1,4- uridine a [protein]-L-5 2-dehydro-3- RNase R degradation a Chi-site containing a dimer of non-adjacent an aldehyde D-glucosamine dethiobiotin cob(II)alamin glutamate-1- methionine kinase: pdxY (deaminating): dadA decarboxylase selenate isoguanine D-tartrate 2-oxoglutaramate choline ν a double stranded DNA synthetase: bioD GTP synthase: metH pyridoxine 5'- pyridoxamine dehydrogenase: gapA transketolase: iaaA B: gadB Fatty Acid and Lipid Degradation methylacetoacetate pyranopterin MoaD-S benzoquinone D-ala PLP in 23S rRNA glutamate-O deoxy-D-gluconate octanoate acyl-carrier protein substrate RNA double stranded RecA 2'-deoxycytidine and h YcbU thiamine semialdehyde quinolinate a thiocarboxylated thymine phosphate -methyl-ester DNA with a blunt end thymidine in DNA cyclohydrolase monophosphate aminotransferase: [small subunit of cyclic pyranopterin pyridoxal phosphate 5'-phosphate tktA 2-keto-3- choline RNase R: rnr DNA exonuclease: recE I: folE thiamine salvage II oxidase: pdxH oxidase: pdxH L-asparaginase: selenate oxygenase: β 2605 transport 3-demethylubiquinol-8 kinase: thiL hemL molybdopterin synthase] phosphate kinase: pdxK a 2,3-dihydroxybenzoyl- pyruvate isoguanine D-tartrate -keto ester NAD(P)H:quinone 2-oxoglutaramate D-alanine 23S rRNA protein-glutamate deoxygluconate acyl-ACP monooxygenase: exodeoxyribonuclease deoxyribodipyrimidine pyridoxal of pyridoxal pyridoxal dethiobiotin 7,8-dihydroneopterin [EntB aryl- a seryl-[EntF L- 13-DPG ansA glutamate fatty acid β-oxidation I reductase: deaminase: dehydratase: rutA reductase: oxidoreductase: transaminase: pseudouridine methylesterase: synthetase: aas V: recD recC recB photolyase: phr 5' to 3' exonuclease: polA D-glucopyranose L-alanyl-γ-D- an osmoregulated quinolinate seryl-carrier protein] D-sedoheptulose D-glyceraldehyde β ynfE ynfF amidase: yafV aldolase: yagE yeaX yeaW glycerol 2- poly-3- an osmoregulated 3'-triphosphate dihydrofolate carrier protein] decarboxylase oleate -oxidation codA fumB dkgA qorB glyA synthase: rluB cheB a nucleoside 5'- a double stranded DNA a 2'-deoxycytidine dipeptide glutamyl-meso-2,6- hydrogen cyanide thiosulfate periplasmic glucan with 3-demethylubiquinone- thiamine phosphoribosyltransferase 4-amino-2-methyl-5- S-adenosyl-L-methionine cycle I reductase: folM 7-phosphate 3-phosphate asp A: gadA ynfG ynfH a diribonucleotide a thymidine in DNA a 5'-phosphomononucleotide a single stranded DNA 6-phosphate hydroxybutanoate cob(II)alamin- 5-aminolevulinate (Z)-2- MoaD molybdopterin 2605 α D-glyceraldehyde an octanoyl-[acp] glycolaldehyde monophosphate with a RecA protein in DNA ABC a dipeptide phosphate thiosulfate- periplasmic glucan biotin 8 3-O- diphosphate (decarboxylating): nadC pyrimidinemethanol molybdopterin phosphoglycerate a 2,3,4-saturated methylureidoacrylate ethyl-(2R)-methyl-(3S) methyl-1,4- pyridoxamine pyruvate a pseudouridine MeOH a [protein]- - pyruvate trimethylamine loaded 3' overhang a dipeptide glucose-6- poly-3- diaminopimeloyl- phosphoglycerol substituent SfmF methyltransferase: ubiG [corrinoid dihydroneopterin 4-aminobutanoate coenzyme A xanthine oxaloacetate 2-oxoglutarate 5'-phosphate L-glutamate transporter glycerol-2- phosphoglycerol synthase: bioB adenosyltranferase] triphosphate 2'- synthase: dihydrofolate kinase: pgk fatty acid (2E,5Z)- selenite peracid -hydroxybutanoate benzoquinol in 23S rRNA phosphate D-alanine peptidoglycan LD- sulfurtransferase: ygaP hydroxymethylpyrimidine moaD moaE NAD salvage pathway I (PNC VI cycle) 2,3-dihydroxybenzoyl- tetradecenoyl-CoA phosphate hydroxybutyrate transferase: opgB biotin BioP biotin epimerase: folX porphobilinogen NaMN reductase: folA PLP transaldolase: phosphatase: carboxypeptidase: thiosulfate an osmoregulated kinase: thiD SAM [EntB]:seryl-[EntF] 2,3- talA phosphatase: synthase: ydcS γ an osmoregulated biotin ubiquinol-8 synthase: hemB dihydroxybenzoate L-alanyl- -D- mepS sulfurtransferase: pspE periplasmic glucan with nicotinate- a 7,8-dihydrofolate gcv system:a lpd 5-methyltetrahydrofolate 3-phospho-D-glycerate short chain phoA 7,8-dihydromonapterin + transferase: entF 3 2 phoA poly-3- glutamyl-meso- D-ala periplasmic glucan hydroxymethylpyrimidine 5,10-methylenetetrahydrofolate:glycinegcvP gcvH gcvT transaldolase: acyl-CoA thiocyanate sulfite phosphoglycerol substituent triphosphate mononucleotide kinase: pdxK molybdopterin NAD ∆ -cis-∆ -trans- enoyl-CoA 2+ α sn-glycero-3- D-glucopyranose porphobilinogen talB synthetase: hydratase: Fe 5-nitro oxalyl-CoA his717 methylglyoxal L-rhamnonate hydroxypyruvate phosphoenol a cytosine in DNA an exoaminopeptidase 6-(glutathion-S-yl)-2- glutathione O-succinyl-L- UDP- -D-glucose a lipopolysaccharide glycerol hydroxybutanoate diaminopimelate YbgD cob(I)alamin- citrate lyase activation hydroxymethyltransferase: glyA Carboxylate Degradation fadK enoyl-CoA benzisoxazole a type IV prepilin PtsP ala pimeloyl-CoA NorV nitric oxide methylhydroquinone carbamoyl phosphate HypE phosphoethanolamine [corrinoid adenylyltransferase: 5-(2-hydroxyethyl) 2,3-bisphosphoglycerate- isomerase: fadJ RssB ArcB-P pyruvate substrate homoserine YidD -4-methylthiazole independent phosphoglycerate lipopolysaccharide adenosyltranferase] hydroxymethylbilane nadD HMP-P molybdopterin a DHB-seryl-[EntF L- mutase: gpmA fadB non-heme S-glutathionyl- L-1-glycerophophorylethanolamine adenylyltransferase: thymidylate phosphoglycerate D-erythrose F6P Kemp oxalyl-CoA methylglyoxal L-rhamnonate hydroxypyruvate leader DNA-cytosine 8-amino-7- examinopeptidase: hydroquinone O-succinylhomoserine carbamoyltransferase: glucosyltransferase: phosphodiesterase: ugpQ γ siroheme biosynthesis 3'-dephospho- synthase: hemC synthase: thyA seryl-carrier protein] mutase: gpmM 4-phosphate fatty enoyl-CoA bacterial eliminase: decarboxylase: dehydratase: peptidase: methyltransferase: oxononanoate ypdE lyase: metB hypF waaJ 2+ D-glucose 1- 2-phospho- L-alanyl- -D- an (S-diacyl-sn- cobalamin CoA nicotinate adenine hydroxyethylthiazole mog methionine L-ascorbate 2-methylcitrate cycle I hydratase: ferritin: pdxI oxc reductase: ydjG rhmD isomerase: hyi gspO dcm reductase: yqjG N-acetylneuraminate NanT N-acetylneuraminate Fe an L-1- adenosyltransferase: kinase: thiM phosphomethylpyrimidine NAD+ degradation II L-ascorbate pyruvate decarboxylation to acetyl CoA D-malate acyl-CoA ftnA synthase: bioF a HypE hydrogenase sn-glycerol glutamyl-meso-2,6- an mRNA glyceryl)-L-cysteinyl- 7,8-dihydromonapterin dinucleotide kinase: thiD adenosyltransferase: transketolase: degradation synthetase: fadB 8-amino-7- oxidized a proteinogenic succinate 2-oxobutanoate UDP a D-glucosyl- ethanolamine 3-phosphate phosphate D-glycerate phosphatidylethanolamine btuR preuroporphyrinogen molybdopterin metK synthetase, enterobactin (bacterial, aerobic) degradation I (3E,5Z)-tetradeca- 2-dehydro-3-deoxy- a cleaved type PtsP- pyruvate nitrous oxide flavorubredoxin amino acid a peptide GSSG toluquinol maturation protein- lipopolysaccharide ferroxidase: glucose 1- diaminopimeloyl- [apolipoprotein] YddK triphosphoribosyl- a (6S)-5- 2-phospho-D-glycerate tktA fadD 3,5-dienoyl-CoA 2-cyano-4- ArcB RssB-P tartronate a peptide phosphorylated a 5-methylcytosine coenzyme A S-carboxamide apolipoprotein N- YoaE uroporphyrinogen-III 4-methyl-5-(2- adenine dinucleotide glutamine synthase: entF (bacterial, anaerobic) 3 2 [FeO(OH) formyl-CoA acetol L-rhamnonate IV prepilin oxononanoate peptidoglycan LD- dephospho-CoA met SAH formyltetrahydrofolate dependent: nadE propanoate nitrophenol semialdehyde in DNA bfr phosphate phosphoglycerate D-alanine RNase I adenosylcob(III) dihydromonapterin NAD+ NAD+ phosphooxyethyl) HMP-PP a [pyruvate ∆ -cis-∆ ] monomer acyltransferase: lnt S-adenosyl-L- alamin-[corrinoid synthase: citG synthetase, synthetase, thiazole 5,10- nicotinate adenine dinucleotide NMN transketolase: L-ascorbate L-ascorbate (R)-malate acyl-CoA (S)-3-hydroxy-(5Z) ferroxidase: phosphatase: phosphatase: phoA carboxypeptidase: endoribonuclease: rna an N-acyl-(S-diacyl- reductase: folM uroporphyrinogen- molybdopterin tktB dehydrogenase6 -trans- γ a 2-acyl-1-lyso- methionine:uroporphyrinogen- adenosyltranferase] III synthase: hemD glutamine NH3- methylenetetrahydrofolate 5-formyltetrahydrofolate enterobactin enolase: eno propionyl-CoA 6-phosphate E2 protein] N a 2,3,4-saturated enoyl-CoA thioesterase: -tetradecenoyl-CoA L-alanyl- -D- mepS sn-glyceryl)-L- III C-methyltransferase: cysG 2'-(5''-triphospho- molybdotransferase: synthetase: D-malate fatty acyl CoA cueO phoA dependent: dependent: cobalamin- reductase: metF -lipoyl-L-lysine isomerase: fadM 3+ glutamyl-meso- D-ala phosphatidylethanolamine n-hexane n-hexane moeA cyclo-ligase: fau 55 multidrug 5,6,7,8- α-D-ribosyl)-3'- nadE nadE independent methylenetetrahydrofolate nicotinate- D-glyceraldehyde prpE L-ascorbate- dehydrogenase 34 (R)-glycerate an mRNA fragment cysteinyl-[lipoprotein] decanoate decanoate fadB glu-Me + + Fe D-glucopyranose YdeR efflux pump precorrin-1 tetrahydromonapterin dephospho-CoA thiamine homocysteine dehydrogenase: folD mononucleotide NMN 3-phosphate L-dehydro- 6-phosphate pyruvate:[dihydrolipoyllysine- (decarboxylating) d-biotin d his thiosulfate β-D-fructofuranose a uridine a uridylylated RNase II poly-A a PepB a single a ribonucleoside a dimer of non- lactulose a reduced ferredoxin a 5-methylaminomethyl-34 a uridine a 5,10- diaminopimelate chenodeoxycholatechenodeoxycholate heme b biosynthesis uroporphyrinogen-III S-adenosylhomocysteine phosphoenolpyruvate lactonase: (3E,5Z)- -sulfoxide (R)-NADPHX in tRNA Trg RssB acetyl phosphate substrate mRNA aminopeptidase NADP H selenophosphate gly AcrAB-TolC I (aerobic) phosphate MoO2-molybdopterin transmethylase: metE a 5,10- a 5,10- adenylyltransferase: nucleosidase ascorbate residue acetyltransferase]-pyruvate : dmlA ATP an mRNA KdpD-P PhoB PII protein stranded DNA triphosphate adjacent 2'- ν [iron-sulfur] cluster 2-thiouridine in tRNA in tRNA methylenetetrahydrofolate L-carnitine L-carnitine [+ [+3 more]3 more] + synthase: thiE nucleosidase: mtn methylenetetrahydrofolate methenyltetrahydrofolate propanoate:CoA ulaG lipoate tetradecadienoate substrate deoxycytidines h cofactor nadD lipoyllysine 2- exoribonuclease: lactulose + apo-citrate lyase NAD ligase (AMP- acetyltransferase6 biotin 55 DNA in DNA tRNA 2-selenouridine S-adenosyl-L- pyruvate kinase: pykF oxidoreductase: aceE pyruvate dodecenoyl- NADPHX thiosulfate manno(fructo) tRNA protein-glutamate PII-UMP rnb aminopeptidase: galactohydrolase: ferredoxin-NADP 5-carboxymethylaminomethyluridine- CaiT methionine:precorrin-1 C- adenosylcobalamin phosphoribosyl- methionine phosphoenolpyruvate forming): acs 3-keto-L-gulonate N -(dihydrolipoyl) acyl-CoA CoA D- sulfoxide epimerase: poly(A) sulfurtransferase: pseudouridine methylesterase: deuridylylation: pepB primase: reductase: fpr synthase: selU tRNA synthase: mnmE mnmG peptidoglycan uroporphyrinogen-III dephospho-CoA methenyltetrahydrofolate lysine:NAD+ dehydrogenase: kinase: mak deoxyribodipyrimidine lacZ 34 γ γ 3-phospho- methyltransferase: cysG synthase: metH synthetase: ppsA pyruvate kinase: pykA 6-phosphate isomerase: reductase: nnr polymerase: glpE synthase: truB cheB glnD dnaG photolyase: phr -butyrobetaine -butyrobetaine Ins(1,2,3,4,5,6)P6 DHAP trimethylamine a reduced a 5-L-glutamyl- YajR transferase: citX cyclohydrolase: folD NaMN nicotinamide propanoyl-CoA oxidoreductase: lpd fadE a (3Z)-alk-3- bisC RNase II β a 5-methylaminomethyl- a 5-carboxymethylaminomethyluridine DAP-DAP an amino acid thiamine phosphate S-ribosyl-L-homocysteine fadJ pcnB asp53 55 glu a proteinogenic -D- an oxidized ferredoxin thiophosphate a 7,8-dihydrofolate D-glycerate YadL uroporphyrinogen lipoate L-homocysteine enoyl-CoA acetate RssB-P AMP substrate with a peptide amino acid an ssDNA/RNA a 2'-deoxycytidine D-fructofuranose NADPH 2-selenouridine in tRNA in tRNA glycerone N-oxide TorY protein [peptide] decarboxylase: hemE nicotinamidase: sedoheptulose dehydroascorbate PhoB-P KdpD F6P a pseudouridine Trg MeOH UMP a PII protein no poly-A tail in DNA galactopyranose [iron-sulfur] cluster trimethylamine crosslink peptidoglycan LD- precorrin-2 lipoate biosynthesis and pyruvate bisphosphate bypass (bicyclic form) a [pyruvate a [pyruvate (S)-NADPHX an mRNA sulfite primer hybrid 3-phytase: 3-phosphoglycerate γ-glutamyltranspeptidase: a holo [citrate incorporation I lipoate salvage I S-ribosylhomocysteine a 10-formyltetrahydrofolate pncA 2-methylcitrate 3-keto-L- biotin in tRNA phosphate biosynthesis and thioredoxin dehydrogenase6 dehydrogenase6 a 2,3,4-saturated a trans-2- N-oxide endopeptidase: coproporphyrinogen III lyase acyl- thiamine pathway lyase: luxS synthase: prpC gulonate-6- agp phosphatase: phoA α ggt NAD salvage pathway II (PNC IV cycle) carrier protein] incorporation II glutathione biosynthesis monophosphate phosphate E2 protein] N E2 protein] N -S- fatty acyl CoA enoyl-CoA phosphatase: reductase: torZ mepA an -(5-L- precorrin-2 pyruvate D-sedoheptulose -dihydrolipoyl- lipoate acetyldihydrolipoyl- peptidoglycan peptidoglycan kinase: thiL nicotinate 7-phosphate decarboxylase: acetyltransferase: D-myo-inositol phoA an oxidized a peptide glutamyl)- YeeR dehydrogenase: cysG an octanoyl-[acp] (R)-lipoate folate polyglutamylation dehydrogenase: ulaD L-lysine L-lysine acetyl-CoA C- enoyl-CoA trimethylamine tetrapeptide, tripeptide, coproporphyrinogen citrate lyase octanoate phosphoribosyltransferase: aceE aceF lpd (2S,3S)-2-methylcitrate aceF acyltransferase: hydratase: 65 (R)-glycerate YfcV + acyl carrier protein metabolism an oxidized sedoheptulose- glu-Me MoO2- + + (1,2,4,5,6)- dihydroxyacetone TorY protein amino acid III oxidase: hemF synthetase: octanoyl pncB fadI fadB glyoxal a double α-ribazole cys24 DHAP glycolaldehyde a uridine glyoxylate pyridoxamine oxaloacetate a peptide with a an mRNA isoprimeverose an L-1- cellulose pyruvate deoxycholate deoxycholate glycan chain 2 glycan chain 1 NAD glu thioredoxin 7-phosphate 2,3-dioxo- acetyl-CoA acetoacetate stranded DNA in tRNA Tar a tRNA precursor molybdopterin molybdopterin a tRNA precursor phosphatidylethanolamine K+ K + sirohydrochlorin citC transferase: thiamine diphosphate lipoate-ATP L-xylulose degradation 5'-phosphate BglG BglF-P leader sequence MdtM pentakisphosphate octanoate- lipB adenylate AI-2 5,6,7,8- a 10- kinase: pfkA L-gulonate conversion of succinate to propanoate cofactor Na Na non- tetrahydrofolate formyltetrahydrofolate nicotinate acetyl-CoA 2-methylcitrate 5-phosphate (to acetyl CoA) glyoxalase pyridoxamine- RNase: celulose pyruvate:ferredoxin protoporphyrinogen IX a [lipoyl-carrier6 transferase: D-sedoheptulose enoyl-CoA 65 protein-glutamate RNase D [+ 2 more] [+ 2 more] an acetyl-holo a holo acyl- lipoylated 1,7-bisphosphate dehydratase: acetyl-CoA 3-ketoacyl- III: elbB gyrase: α-ribazole-5'-P methylglyoxal glycolaldehyde tRNA 2-hydroxyglutarate oxaloacetate leader bis(molybdenum endoribonuclease yoeB isoprimeverose phosphoethanolamine oxidoreductase YgjQ sirohydrochlorin carrier protein glutamate--cysteine protein] N - lplA 2,3-diketo- prpD CoA hydratase: phosphatase: reductase: yqhD pseudouridine methylesterase: exonuclease: peptidase: lepB cofactor) BN: rbn α-xylosidase: yicI N-acetyl-muramoyl-(L- a partially deacetylated poly-β- [citrate lyase acyl- apo domain octanoyl-L-lysine glutathione-glutaredoxin gyrA gyrB synthase: mgsA rnd synthase transaminase an RNase transferase: bcsG + D-ribose 5- a double a single- ferrochelatase: cysG carrier protein] ligase: gshA 10-formyl- oxaloacetate L-gulonate L-ribulose-5- succinyl-CoA thiolase: fadJ acetoacetate glyoxalase cobC synthase: truC cheB synthase: mobA an RNase product a reduced YebF protoporphyrinogen ligase: lplA redox reactions thioredoxin propanoyl CoA a single-stranded product with a 1,2-diacyl- H ferredoxin [iron- CO2 acetyl-CoA asn alanyl-γ-D-glutamyl-L- 1,6-N-acetyl-D-glucosamine I (lipoyl)adenylate tetrahydrofolylpolyglutamate sedoheptulose reductase: phosphate 3- fadA III: yajL his101 65 glu a leader sequence a peptide bis(molybdenum mature tRNA with a 5' OH phosphoethanolamine phosphate stranded DNA stranded RNA oxidase: hemG NAD+ lipoyl reductase: NAD salvage cis-2-methylaconitate degradation I methylmalonyl- acetate CoA- a nucleoside 5'- a tRNA asp pyridoxal oligoribonucleotide a 3' phosphate α sulfur] cluster asparaginase: ribose 5- endo-poly-β-1,6- a [lipoyl-carrier6 γ 5,10- synthetase: folC bisphosphate yiaK epimerase: a (3S)-3- a negatively BglF BglG-P ethylene glycol a pseudouridine Tar MeOH -D-xylopyranose D-glucopyranose cellulose sn-glycerol lysyl-D-alanyl-D-alanine)D-alanyl-D-alanine siroheme synthetase, gly -L-glutamyl- synthase: trxB pathway IV (from citrate synthase: gltA aldolase: fbaA ulaE CoA a 3-oxoacyl-CoA transferase: ydiF α-ribazole methylglyoxal monophosphate 2-hydroxyglutarate cofactor) protein] N - L-cysteine methylenetetrahydropteroyl malate propionyl- mutase: scpA hydroxyacyl-CoA glycolate supercoiled DNA in tRNA iaaA phosphate endonuclease RNase I D-glucosamine glutamine holo-[acyl octanoyl-L-lysine lipA glutathione lipoyl- mono-L-glutamate nicotinamide riboside) NAD phosphorylation dehydrogenase: mdh carboxypeptidase: WecH protoporphyrin IX dependent: carrier adenylate- a tetrahydrofolate a 10- (2R,3S)-2- propanoyl-CoA CoA:succinate acetoacetyl-CoA asparaginase: phosphatase: I: endA endoribonuclease: rna hydrolase: pgaB formyltetrahydrofolate β and dephosphorylation D-erythrose 3-keto-L-gulonate methylisocitrate L-ribulose 5- CoA N-acetyl-muramoyl-(L-dacC a partially deacetylated a partially deacetylated nadE protein] a [lipoyl-carrier6 -protein 1-( -D DHAP transferase: lipoyl malate dehydrogenase, 4-phosphate hydro-lyase: acnB phosphate propionyl- transferase: 3-hydroxybutyryl- ansB phoA SfmA nicotinate adenine synthase: ligase: lplA ribofuranosyl) malate:quinone CoA atoA atoD 13 γ β β NMN synthase: glutathione protein] N -[(R) + NAD-requiring: maeA 37 D-ala alanyl- -D-glutamyl- poly- -1,6-N-acetyl-D- poly- -1,6-N-acetyl-D- ferrochelatase: a reduced CoA scpC β 3 HcaT a 5'-phosphooligonucleotide an rRNA fragment dinucleotide acpT synthetase: -dihydrolipoyl]- nicotinamide oxidoreductase: mqo epimerase: fadJ a [protein]- a uridine glu-Me 2,3- a peptide with dTDP- -L- glucosyl-(heptosyl) - 3-phenylpropanoate 3-phenylpropanoate asp aldehydo-D-ribose hemH lipA a reduced α 5,10-methylenetetrahydrofolate:glycine ribosylnicotinamide NAD 3-keto-L- carboxylase his816 dimethylallyl a lipopolysaccharide an adenosine UDP-α-D-glucuronate L-lysyl-D-alanine) glucosamine (fragment 2) glucosamine (fragment 1) acyl carrier protein gshB L-lysine thioredoxin folylpoly- - Electron Transfer (2R,3S)-2- (R)-methylmalonyl- acetoacetyl-CoA D-serine nitric oxide L-glutamine L-tartrate a quinone in tRNA Tap 4-hydroxy-L-threonine EF-P β dihydroxybenzoyl- FMNH2 ser 2,3-dihydroxybenzoate an N-terminal rhamnose DMAPP glutathione Kdo2-lipid A-phosphate NMN glutaredoxin a [lipoyl-carrier6 hydroxymethyltransferase: glyA gulonate L-ribulose-5- propanoyl-CoA OmpR BarA-P (R)- -lysine phosphate in tRNA phosphodiesterase: glutamate kinase: nadR methylisocitrate (S)-methylmalonyl- CoA EntB Xaa-L-proline YigF S-adenosyl- amidohydrolase: a [lipoyl-carrier6 protein]-N - kinase: phosphate 4- 3-hydroxyacyl-CoA menaquinol-8 biosynthesis acpH synthetase (S)-malate citrate CoA 3-hydroxybutyryl- protein- flavin lipopolysaccharide tRNA glutathione-specific γ- UDP- L-methionine ferroheme b pncC holo-[acyl- protein] N -[(R) lipoyl-L-lysine NMN lyxK epimerase: dehydrogenase: CoA acetyl-CoA D-serine nitric oxide L-tartrate NADPH:quinone tRNA 13 protein-glutamate 4-hydroxy- EF-P-lysine proofreading enterobactin aminopeptidase: core rhamnosyl biosynthesis γ glutathionylspermidine 2-methylisocitrate ulaF fadJ glutamine dehydrogenase: pseudouridine L-threonine thioesterase: prenyltransferase: dimethylallyltransferase: glutamylcyclotransferase: glucuronate:LPS(HepIII) carrier- -dihydrolipoyl]- glutaredoxin:protein folylpoly- - a 5,10- ATP epimerase: fadB acetyltransferase: ammonia- dioxygenase: oxidoreductase: methylesterase: lysyltransferase: synthase: entB pepA transferase: waaS chaC glycosyltransferase: waaH L-glyceraldehyde a 2'- L-lysine glutathione disulfide biosynthesis biosynthesis lyase: prpB methylmalonyl- atoB hmp glutaminase: dmlA qorA synthase: truD cheB aldolase: ltaE epmA entH ubiX entD entF entE miaA 2,3- YfcR protein] methylenetetrahydrofolate pyridine nucleotide NAD lyase: a peptide with 6 37 a 23S rRNA nicotinate- reductase: grxB glutamate NADP 3-keto-L-gulonate CoA epimerase cheB a proteinogenic glucosyl-(heptosyl)3-glucosyluronate- asn deoxyribonucleoside demethylmenaquinol-8 synthase: NMN transhydrogenase: kinase: fumarase: fumE citrate hydro-lyase: acnB D-xylulose dsdA 13 glu protein chain an N-terminal dTDP a rhamnosyl N -dimethylallyladenosine UDP GMP 3-phosphate dihydroxybenzoate mononucleotide phosphatase 6-phosphate 3-hydroxyacyl-CoA OmpR-P 2,3- prenylated FMNH2 amino acid 5-oxo-L-proline L-cysteinylglycine 2 met adenylyltransferase: acpS synthetase: adenylyltransferase: pntB pntA nadK succinate pyruvate 5-phosphate a (3R)-3- α BarA 2-hydroxy-3- a pseudouridine Tap MeOH gly glycolaldehyde elongation factor dihydroxybenzoate b0595 enterobactin L-proline lipopolysaccharide in tRNA Kdo -lipid A-phosphate asparaginase: L-glyceraldehyde 3'-monophosphate leu LeuE leu S-adenosylmethionine:2- methylene- spermidine glutathione fumarase: fumD dehydrogenase: acetyl-CoA nitrate a [protein]- - oxosuccinate a semiquinone in tRNA β nucleoside 5'- met met nadD glutaredoxin: folC nadR malate synthase A: aceB citrate hydro-lyase (cis- (R)-methylmalonyl- fadB hydroxyacyl-CoA pyruvate L-glutamate EF-P, -lysyl-Lys34 iaaA 3-phosphate RNase I 2'-deoxyribonucleoside 2,3-dihydroxybenzoate:oxygen methionine demethylquinol-8 tetrahydrofolylpolyglutamate aconitate-forming): acnA ADP methylmalonyl- monophosphate adenosyltransferase: grxC synthetase: folC glutathionylspermidine fumarase A: fumA CoA CoA endoribonuclease: rna 3'-monophosphate oxidoreductase: cueO methyltransferase: ubiE synthetase: gss + 3-keto-L- 3-hydroxy-trans-cinnamate 3-hydroxy-trans-cinnamate asparaginase: phosphatase: metK NaMN NAD fumarase B: fumB gulonate-6- decarboxylase: MhpT phosphatase: aphA YhjY ile + superpathway of acetate scpB 3-(3-hydroxyphenyl)propanoate 3-(3-hydroxyphenyl)propanoate phosphatase: aphA menaquinol-8 an apo acyl- a protein dithiol glutathionylspermidine NADP ATP phosphate utilization and formation methylmalonyl- ansB guanosine phoA ile val SAM a tetrahydrofolate a 5,10- fumarase C: fumC synthase: CoA 32 967 6 an rRNA fragment a 2'- 2-carboxymuconate carrier protein fumarate cis-aconitate decarboxylase: 54 + asp L-glyceraldehyde val methylenetetrahydrofolate mutase: scpA a trans-2- N-acetyl-D- a uridine glu-Me a cytosine maltoheptaose a [ThiI sulfur- 2-hydroxycyclohepta-1,4,6- a [protein]-N - leu YjeH leu atpB atpF sgbH citrate degradation glucosamine his265 pyrazinamide a quinone a uracil in tRNA tellurite ferroheme b (2E,6E)-farnesyl glutathione a protein disulfide NAD deoxyribonucleoside atpE atpD ATP enoyl-CoA CreC-P PhoB in tRNA Tsr in 16S rRNA diphosphate AceF lipoyl-ACP carrier protein]- a uracil in tRNA triene-1-carboxyl-CoA acetyl-L-lysine met acetyl-CoA glyoxylate isocitrate lyase: aceAD-threo-isocitrate atpG atpA acetate S-sulfanyl- met hydro-lyase: acnB 5 5 maltodextrin reduced 2-hydroxycyclohepta- protein-lysine succinate:quinone atpH atpC L-xylulose acetyl-CoA succinyl-CoA trans-2- N-acetyl-D- FMN dependent tRNA 32 protein-glutamate tRNA(m U54) tellurite 16S rRNA m C967 heme O phosphorylase: lipoyl-protein glutaredoxin 2: grxB L-cysteine oxidoreductase: sdhD an acetyl-holo synthetase enoyl-CoA glucosamine pyrazinamidase: NADH:quinone pseudouridine methyltransferase: methyltransferase: methyltransferase: synthase: 1,4,6-triene-1-carboxyl- deacetylase: γ YehD 5-phosphate Amine and Polyamine Degradation adenylate pncA methylesterase: malP ligase: lipB tRNA uridine 4- CoA thioesterase: paaY cobB di-trans,octa-cis D-glyceraldehyde core a peptidoglycan with (L-alanyl- -D- sdhC sdhB sdhA D-threo-isocitrate [citrate lyase acyl- citrate acetate (AMP- allantoin degradation reductase kinase: nagK reductase,: azoR synthase: rluA cheB trmA tehB rsmB cyoE glutaredoxin 3: grxC sulfurtransferase: thiI M-antigen YhgN hydro-lyase (cis- ATP carrier protein] forming): acs IV (anaerobic) allantoin degradation cyclase: α YncL PLP -undecaprenyl (S)-5-hydroxyisourate oligosaccharide- Lpp glutamyl-meso-2,6-diaminopimeloyl- kinase: superpathway of N-acetylglucosamine, to glyoxylate III cyaA asp53 32 glu 54 967 -D- acyl-carrier protein AceF-lipoate a [ThiI sulfur- 2-hydroxycyclohepta- 2''-O-acetyl- 3-phosphate Nucleoside and Nucleotide Biosynthesis aconitate-forming): acnA L-xylulose 5- citrate-ACP ackA N-acetylmannosamine and N- N-acetyl-D- Tsr ferroheme o glucopyranose maltohexaose a protein dithiol GSSG carrier protein]- a 4-thiouracil coenzyme A nicotinamide a [protein]-L-lysine undecaprenyl D-glyceraldehyde (variant) monomer transferase: a 2,3,4-saturated glucosamine PhoB-P CreC pyrazine-2- a semiquinone a pseudouridine MeOH a 5-methyluracil a 5-methylcytosine in tRNA 1,4,6-triene-1-carboxylate ADP-ribose pyridoxal 5'- diphosphate lipid A (E. coli D-alanine) tetrapeptideL,D-transpeptidase: ldtB superpathway of aromatic amino acid biosynthesis Amino Acid Biosynthesis phosphate 3- acetylneuraminate degradation fatty acyl CoA carboxylate in tRNA in tRNA methanetelluronate in 16S rRNA 1-phosphate L-cysteine 5-hydroxyisourate undecaprenyl superpathway of branched chain amino acid biosynthesis L-cysteine biosynthesis I epimerase: citD citF citE (S)-(+)-allantoin cyclic-AMP 6-phosphate pyrophosphate 3-phosphate N-acetylneuraminate NanC N-acetylneuraminate L-proline L-histidine biosynthesis ammonia superpathway of L-serine a citryl-holo (S)-(+)-allantoin phosphate K-12 core type) L,D-transpeptidase: ldtC biosynthesis I assimilation cycle III and glycine biosynthesis I superpathway of purine nucleotides de novo biosynthesis II succinate D-threo-isocitrate sgbU N-acetylneuraminate phosphatase: phosphatase: hydrolase: yedX diphosphate StfR superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli) [citrate lyase acyl- acetyl phosphate acetyl-CoA D-gluconate phosphatase: (no GlcNAc) L,D-transpeptidase: ldtA YgbE D-erythrose superpathway of L-lysine, L-threonine and L-methionine biosynthesis I superpathway of pyrimidine salvage pathways of pyrimidine adenine and adenosine salvage II carrier protein] degradation allantoinase: lipopolysaccharide di-trans,octa-cispgpB (S)-2-oxo-4- di-trans,octa-cis a peptidoglycan tripeptide 4-phosphate deoxyribonucleotides de novo biosynthesis isocitrate allantoinase: N-acetylneuraminate transport system a lipopolysaccharidea lipopolysaccharide phoA phoA D-ala pyruvate deoxyribonucleotides dehydrogenase: icd succinate L-ribulose 5- allB allB 35 746 34 1939 34 thr 3-phospho-D-glycerate ser phosphate lyase: nanA -undecaprenyl D-glyceraldehyde hydroxy-4-carboxy- -undecaprenyl E. coli MLPS crosslinked to lipopolysaccharide glu ammonium glu PRPP CTP succinyl-CoA citryl-ACP (5Z)- a uridine uridine a cytidine in met a uracil a single- RNase E mRNA an aminated amino a 2-thiouridine a 5,10- UDP-N-acetyl- pyridoxal PRPP ATP D-gluconate N-acetyl-D- allantoate acryloyl-CoA DNA with lesion ppGpp a [protein]-L-lysine a tripeptide 2-oxobutanoate a lipopolysaccharide α phosphate 3-deoxy-7- oxaloacetate D-3-phosphoglycerate 2'-deoxycytidine synthetase: sucD sucC lyase: citD GTP thiamine dodecenoyl-CoA in tRNA in 23S rRNA [elongator tRNA ] in 23S rRNA stranded RNA SucB lipoyl-ACP processing group donor in tRNA methylenetetrahydrofolate -D-glucosamine 5-ureidoimidazoline diphosphate phosphoheptulonate acetolactate glutamine citF citE allantoate mannosamine diphosphate ADP substrate glutamate 5- dehydrogenase: serA gln hydrogencarbonate adenosine L-ribulose-5- Tyr Met 5 synthase: aroF synthase: threonine synthetase: glnA serine D-gluconate polynucleotide tripeptide 2-oxobutanoate 5-aminomethyluridine- lipopolysaccharide 1,2-N- Ag43 kinase: proB deoxycytidine phosphate 4- kinase: gntK acrylyl-CoA Nucleotide ppGpp acyl-CoA tRNA 35 23S rRNA 746 peptidyl-lysine tRNA cytidine 23S rRNA m U1939 lipoyl-protein ribonuclease: YdgC ilvI ilvH deaminase: acetyltransferase: amidophosphoribosyltransferase: purF phosphate N-acetylmannosamine allantoate excision ThDP phosphorylase: aminopeptidase: aminotransferase: tRNA synthase: acetylglucosaminetransferase: γ-L-glutamyl ilvA aspartate ATP gln 3-phosphooxypyruvate cysE deaminase: cdd adenosine epimerase: amidohydrolase: reductase: phosphohydrolase: dehydrogenase: pseudouridine pseudouridine acetyltransferase: acetyltransferase: methyltransferase: pnp pepT ligase: lipB rne avtA mnmE mnmG waaU CMP an E. coli transaminase: nucleosidase: sgbE oxaloacetate acetyltransferase: allantoate kinase: nanK guanylate yhdH repair: uvrB adenylyl nudG fadE synthase: rluF synthase: rluA patZ tmcA rlmD cysteamine a phosphate 3-deoxy-7- 5-phosphate phosphoribosyltransferase: CDP superpathway of glycolysis and the Entner-Doudoroff pathway eutD D-gluconate amidohydrolase: allC RNase E a protein osmoregulated an L-1- acetolactate aspC hisG β carbamoyl rihC cyclase uvrC uvrA transferase α an aromatic an aromatic S-phosphate monoester GTP H2O phosphoheptulonate (2Z)-2-aminobut- 5-phospho- - phosphate 2'-deoxyuridine succinyl-CoA 2-oxoglutarate kinase: idnK allC N-acetyl-D- ethanolamine utilization adenosine 35 746 6 4 34 1939 a nucleoside a single- a proteinogenic acyl-carrier protein SucB-lipoate an mRNA fragment processing a deaminated a 7,8-dihydrofolate a 5-aminomethyl-2-34 UDP a N-acetyl- -D-glucosaminyl- YddG CMP phosphatase: phoA synthase: 3-phosphoserine (2E,5Z)- a [protein]-N - met stranded RNA a dipeptide 2-aminobutanoate thiouridine in tRNA amino acid amino acid cysteamine periplasmic phosphatidylethanolamine synthase: aroH 2-enoate L-glutamate:NADP+ O-acetyl-L-serine hydrogen sulfide D-ribosylamine synthetase: adenine D-xylulose D-gluconate mannosamine propanoyl-CoA thiamine pGp a pseudouridine a pseudouridine an N -acetylcytidine a 5-methyluracil diphosphate amino acid product mRNA amino group donor lipopolysaccharide acid phosphatase / 5'-ribonucleotidase: ushA GTP glutamate-5- ilvG ilvM oxidoreductase aminotransferase: serC phosphate (S)-ureidoglycine DNA without dodecenoyl-CoA in tRNA in 23S rRNA acetyl-L-lysine in [elongator tRNA ] in 23S rRNA tail-specific semialdehyde carB carA 2'-deoxycytidine D-glucopyranose 5-phosphate acetyltransferase: pta 6-phosphate 6-phosphate cyclic-GMP lesion triphosphate S-phosphate glucan (OPG) YcbV YjfL asp 1-(5-phospho-β-D-ribosyl)-ATP (transaminating) phosphoribosylamine--glycine CDP deoxyuridine 6-phosphate (S)-ureidoglycine protease: phosphotransferase: nucleoside 5'- phosphohydrolase: 3-deoxy-7- dehydrogenase: : gltB gltD diphosphate:oxidized reductase: uracil ethanolamine phosphatase: an E. coli osmoregulated phosphoheptulonate proA acetolactate ligase: purD NrdH glutaredoxin-like nrdA nrdB kinase: tdk adenine N-acetylmannosamine- (S)-ureidoglycine prc aphA monophosphate appA synthase: 3-phospho-L-serine cysteine phosphorylase: + synthase: aroG aspartate phosphoribosyl-ATP synthase: cysM carbamoyl phosphate asp protein oxidoreductase: glucose-6- 6-phosphate aminohydrolase: phoA a 1,2-diacyl- periplasmic glucan with YncD ilvB ilvN deoA (S)-ureidoglycine 34 6 phosphatase: aphA phosphate GDP H kinase: lysC pyrophosphatase: hisI nrdE nrdF phosphoribosyltransferase: apt phosphate epimerase: nanE allE an alcohol GAR dUMP 2-oxoglutarate aminohydrolase: ethanolamine ammonia- an adenosineArg2 a 5' diphospho- an N-hydroxy- peptidoglycan peptidoglycan a 5,10- an N -(1-hydroxy-2- a peptide cysteamine sn-glycerol phosphotidylethanolamine L-glutamate-5- 2-iminobutanoate glu superpathway of 5-aminoimidazole his292 a ribonucleoside [DNA] (3R)-3-hydroxybutanoyl-CoA H2O cytidine 3-deoxy-D-arabino- phosphoserine O-acetylserine dehydrogenase: isomerase: pgi allE lyase: eutB eutC L-carnitine degradation I a protein (S)-NADHX in [tRNA ] L-dopa acetaldehyde L-quinate N-ethylmaleimide [mRNA] arylamine formate tetrapeptide, tetrapeptide, a D-aminoacyl-[tRNA] methenyltetrahydrofolate oxopropyl)-[protein]-L-lysine semialdehyde ribonucleotide biosynthesis + N-acetyl-D- ArcB-P ArcA xanthosine triphosphate substituent YccF heptulosonate (S)-2-acetolactate aspartate phosphatase: serB sulfhydrylase: cysK 2-deoxy-α- sucA sucB lpd glycan chain 2 glycan chain 1 acyl-CoA thioesterase: yciA YcaL 7-phosphate 1-(5-phospho-β-D-ribosyl)-AMP dCDP D-ribose 1- NADP -dependent glucosamine (S)-ureidoglycolate ATP dependent protein deglycase: hchA kinase: phosphoribosylglycinamide aspartate AMP 6-phosphate tRNA 34 ribonucleoside- L,D- putative metL phosphate glucose-6- F6P (S)-ureidoglycolate acetaldehyde (S)-NADHX acetaldehyde quinate N-ethylmaleimide RNA N-hydroxyarylamine DNA exonuclease, D-aminoacyl-tRNA 5,10- formyltransferase: purT carbamoyltransferase: UDP PRPP phosphate L-carnitine dehydratase: adenosine 4,5-DOPA dehydrogenase: dehydrogenase: phosphohydrolase: xanthosine O-acetyltransferase: triphosphate transpeptidase: deacylase: dtd methenyltetrahydrofolate protein deglycase: yhbO (R)-3-hydroxybutanoyl- an oligopeptide an α EcnA pyrB pyrI dCDP deaminase: dioxygenase reductase: nemA reductase: nrdD ldtD 3' -> 5': sbcC sbcD CoA thioesterase: tesB ABC UMP 4-amino-4- UDP-N-acetyl- -D-muramoyl-L- 3-dehydroquinate (2R)-2,3-dihydroxy-3- + phosphoribosyl-AMP ser kinase: adk dehydrogenase: ureidoglycolate nnr aldB ydiB rppH nucleosidase: nhoA hydrolase: glyA protein deglycase: yajL oligopeptide oligopeptide O-phospho- pyridoxine a nucleoside 5'- synthase: aroB methylbutanoate:NADP cys N-acetylglucosamine- tadA extradiol: ygiD rihC transporter α γ aspartate cyclohydrolase: hisI thymidine zwf fructose-1,6- ureidoglycolate 6-phosphate lyase: allA asp54 a 2'-deoxyribonucleoside peptidoglycan a 2'-deoxyribonucleoside an uncharged tRNA a D-amino acid 5'-phosphate monophosphate deoxy- -L- α alanyl- -D-glutamyl-meso-2,6- oxidoreductase FGAR amidophosphoribosyltransferase: purF 34 [DNA] (R)-lactate a [protein]-L-lysine (R)-3-hydroxybutanoate L-tyrosine UMP phosphatase: phoA -D-Kdo-(2->4) CbrB (S)-1-pyrroline- 2-oxobutanoate kinase: thrA dCDP formate UDP 2'-deoxyuridine 5'- phosphorylase: bisphosphatase: dehydrogenase: deacetylase: nagA acetaldehyde alcohol ArcB ArcA-P a 5'-phospho- an N- 5'-triphosphate D-ala DAP-DAP 5'-monophosphate a (6S)-5- arabinopyranosyl diaminopimeloyl-D-alanyl-D-alanine (isomerizing): ilvC UTP NADH an inosineArg2 acetate 3-dehydroquinate N-ethylsuccinimide xanthine D-ribofuranose crosslink O-phospho- pyridoxine-5'- nucleoside α muramoyl pentapeptide YadC 5-carboxylate β 5,10-methylenetetrahydrofolate:glycine L-selenocysteine biosynthesis I (bacteria) kinase: ndk reductase: diphosphate:oxidized ppnP 5-phospho-β- Respiration yggF allD dehydrogenase dehydrogenase: adhE carnitine- a peptide 4,5-seco-dopa [mRNA] acetoxyarylamine formyltetrahydrofolate 5'-ribonucleotidase: ushA - -D-Kdo- 3-dehydroquinate 1-(5-phospho- -D-ribosyl)- NrdH glutaredoxin-like glyoxylate in [tRNA ] phosphate ditrans,octacis carboxypeptidase: dacC acetohydroxybutanoate L-aspartyl- 5-[(5-phosphoribosylamino) hydroxymethyltransferase: glyA phosphoribosylformylglycinamide N-carbamoyl-L-aspartate CTP nrdA nrdB D-ribosylamine D-glucosamine (acetylating): mhpF CoA L-tyrosine monophosphate nucleoside 5'- (2->6)-lipid A EaeH (2R)-2,3- synthetase: purL reductase: protein oxidoreductase: ethanol ligase: α-undecaprenylα pyrroline-5- synthase: ilvG ilvM 4-phosphate methylideneamino]imidazole- nrdE nrdF thymidine fructose 1,6- N-carbamoyl- 6-phosphate caiC phosphatase: phosphatase: phosphatase: aphA 4'- -L-Ara4N- - muramoylpentapeptide dihydroxy-3- 4-carboxamide selenide sec nrdD UTP 2-oxoglutarate decarboxylation to succinyl-CoA 6-phosphofructokinase: dehydrogenase: adhP monophosphate di-trans,octa-cis 3-dehydroquinate carboxylate methylbutanoate a tRNA phosphorylase: phosphoribosylamine--glycine bisphosphatase: 2-oxoglycine acetaldehyde aphA phoA phosphateα dehydratase: aroD acetohydroxybutanoate gly ser dCTP reductase: deoA 6-phospho D- pfkA dehydrogenase: adhE phosphatase: aphA Kdo-(2->4)- - UDP-N-acetylmuramoyl-L-carboxypeptidase: dacA PqiA reductase: superpathway of L-homoserine FGAM dihydroorotase: pyrC nrdD ligase: purD glucono-1,5-lactone ybhA 2 4 a nucleoside -undecaprenyl synthase: ilvI ilvH GDP-4-dehydro- ∆ ∆ a double-stranded + pyridoxine Kdo-(2->6)-[P4'- alanyl-γ-D-glutamyl-meso-2,6- proC aspartate- and L-methionine biosynthesis dUDP α trans- , cis- - enol-oxaloacetate putrescine his299 N-methyl-L- spermidine 2,6- an oxidized a [ThiI sulfur-carrier maltopentaose pyridoxamine a deaminated 1-methyl-dATP 2-oxoglutarate (S)-3-hydroxybutanoyl-CoA H2O an acyl-[acyl- a 2-acyl-1-lyso- tyr uridine D-ala YdeS 1-(5-phosphoribosyl)-5- selenide, a [2-oxoglutarate 6-phosphofructokinase: reduced -D-rhamnose decadienoyl-CoA oligonucleotide formate CheY-ac NAD oligopeptide phosphate 2,3-dihydroxy- semialdehyde dCTP thymidine ethanol DsbB BglG FruB-P tryptophan dimethoxyphenol hydrogenase 3 protein]-L-cysteine cys 5'-phosphate amino group donor carrier protein] phosphatidylethanolamine an an α-L-ara4N]-lipid A diaminopimeloyl-D-alanine NfrA 3-dehydroshikimate isovalerate (S)-2-aceto-2- dehydrogenase: [(5-phosphoribosylamino) water L-serine:tRNASec deaminase: GAR dehydrogenase6 6-phosphogluconolactonase: fructose-1,6- pfkB acyl-CoA thioesterase: yciA ABC methylideneamino]imidazole-4- phosphoribosylformylglycinamide (S)-dihydroorotate dUDP α-D-glucosamine acetyl-CoA GDP-L- 1 maltodextrin oligopeptide oligopeptide dehydratase: hydroxybutanoate asd dikinase: ligase (AMP- dcd kinase: ndk E2 protein] N pgl bisphosphatase: L-carnitinyl-CoA 2,4-dienoyl- oxaloacetate putrescine N-methyl-L- spermidine N - formate cysteine pyridoxamine- 1-methyl-dATP CheY 2-acylglycerophosphoethanolamine transporter pro carboxamide isomerase: hisA asp selD forming): serS cyclo-ligase: purM thymidine -lipoyl-L-lysine 2-oxoglutarate glpX 6-phosphate fucose oligoribonuclease: phosphorylase: demethylase: alkB a drug a drug ilvD crotonobetainyl- CoA keto-enol- aminotransferase: tryptophan acetyltransferase: dehydrogenase: desulfurase: malP phosphate deacetylase: (S)-3-hydroxybutanoyl- acyltransferase: aas EmrD kinase: tdk phosphoribosylglycinamide decarboxylase: synthase: orn + guanosine an L-1- carbonylcyanide m-chlorophenylhydrazone carbonylcyanide m-chlorophenylhydrazone shikimate phosphoribosylglycinamide D-gluconate carbamoyl oxamate phosphate CoA reductase: isomerase: patA oxidase: solA speG fdhF iscS transaminase cobB CoA thioesterase: tesB dehydrogenase: (R)-2,3-dihydroxy-3- + dihydroorotate formyltransferase: purN formyltransferase: purT sucA fcl fadH fumA NADP an osmoregulated a peptidoglycan dimer (generic) L-aspartate 4- 6-phosphate fructose-1,6- phosphate glucosamine- γ hydratase: caiD his208 1 α-D- an L-1- 5'Ap3A phosphoribulosylformimino- sec AIR acetyltransferase: eutD -butyrobetainyl- a [ThiI sulfur- dATP acyl-carrier protein + arg 2',3'-cyclic phosphatidyl- aroE 3-methyl-2- methylpentanoate:NADP semialdehyde aspartate L-cysteine biosynthesis VII (from S-sulfo-L-cysteine) an L-seryl- dehydrogenase: pyrD dTMP dihydrolipoate bisphosphatase: fbp 6-phosphate a reduced maltotetraose glucopyranose an aminated amino PLP succinate formaldehyde 2''-O-acetyl- (S)-3-hydroxybutanoate phosphatidylethanolamine periplasmic glucan YraK YjgL shikimate oxidoreductase AICAR-phosphate kinase: selenophosphate [tRNA ] dUTP CoA:carnitine BglG-P FruB formaldehyde trp N - 3,3',5,5'- a nucleoside 5'- ala carrier protein]-S- group donor nicotinamide ADP-ribose CheY NADP murein hydrolase: mltF CsgB dehydrogenase: oxobutanoate PRPP dehydrogenase: lpd deaminase: CoA GDP-β-L-fucose (2E)-dec-2- 1-pyrroline acetylspermidine tetramethoxydiphenoquinone hydrogenase 3 sulfanyl-L-cysteine 1-phosphate dinucleoside arginine decarboxylase, monophosphate sn-glycerol (isomerizing): ilvC metL FGAR phosphogluconate carbamate phosphate DsbBoxidized oxaloacetate monophosphate guanosine 2'3'-cyclic + + ydiB orotate nagB transferase: enoyl-CoA murein hydrolase: emtA shikimate 5-(carboxyamino) pyrimidine adenine and adenosine salvage III dehydratase: edd β-D-fructosefructose- 1,6- kinase: ybcF acetyltransferase: pta phosphatase: polyphosphate degradative: adiA Na + Na+ dehydrogenase: homoserine imidazole ribonucleosides dUTP bisphosphatebisphosphate caiB phosphodiesterase: an osmoregulated murein hydrolase: mltD ChaA 2-isopropylmalate 4-hydroxy- ser pyrophosphohydrolase: phoA hydrolase: ushA arginine decarboxylase, K K ydiB valine (R)-2,3-dihydroxy- dehydrogenase: imidazole glycerol L-aspartyl- selenocysteine ribonucleotide salvage III phosphoribosylformylglycinamide a [2-oxoglutarate a [2-oxoglutarate aldolase: fbaB γ-butyrobetainyl- crotonobetainyl- synthase: leuA 3-methylpentanoate tetrahydrodipicolinate phosphate synthase: selA orotate nudI F6P acetyl phosphate NADP cpdB periplasmic murein hydrolase: mltC transaminase: synthase: dapA 4-phosphate synthase: purK synthetase: purL dehydrogenase6 dehydrogenase6 KDGP carbamate CoA CoA biosynthetic: speA a 1,2-diacyl- YnfB ilvE metL synthase: hisH hisF phosphoribosyltransferase: cytidine E2 protein] N E2 protein] N -S- DHAP 1407 DgoT D-galactonate ADP AMP glucan with murein hydrolase: slt YchO YdbA adenine 2-keto-3- an organic an aliphatic a cytosine an L-1- α-D-Kdo-(2->4)-α- D-galactonate phosphatase agmatine 3'-GMP serine pyrE -dihydrolipoyl- succinyldihydrolipoyl- fructose syringaldazine his15 an S-(1-hydroxy- spermidine (1S,2R)-1- 1,3-propanediol maltohexaose 5'-deoxyadenosine 1-methyl-dAMP 2-oxoglutarate a 2,3,4-saturated lysine within + sn-glycerol shikimate 2,3-dihydroxy-3- deoxyuridine reduced α ω Npr D-Kdo-(2->6)-lipid A phosphoglycerol (2S)-2- acetyltransferase: an L- cytidine L-lysine L-lysine bisphosphate acetate kinase: purT DsbB ATP ADP hydroperoxide BglG HPr-P 2-oxopropyl) , -diamine PtsN C-(indol-3- in 16S rRNA acyl-carrier protein fatty acid gcv protein H a lipoyl-[acp] phosphatidylethanolamine NAD [+ 2 isozymes] L-valine methylvalerate homoserine aspartate- N5-CAIR nucleosidase: rihC triphosphatase: adenosine FGAM deoxygluconate aldolase: fbaA triose- -[protein]- phosphorylated yl)glycerol ser GlcNAc-1,6-anhydro- val val isopropylmalate hydro-lyase: ilvD dehydrogenase: (2S,4S)-4- cysE selenocysteinyl-sec dut phosphorylase: ppnP phosphate 8 5 maltodextrin 5'-deoxyadenosine 1-methyl-dAMP substituent exporter D-erythro-imidazole- semialdehyde 6-phosphate acetate kinase: ackA polyphenol alkyl L-cysteine diamine N- spermidine N - 3-phosphate 1,3-propanediol 16S rRNA m C1407 acyl-ACP Kdo2-lipid A a lipid II shikimate val thrA hydroxy-2,3,4,5- AICAR dehydrogenase: [tRNA ] 5 isomerase: phosphorylase: nucleosidase: mtn demethylase: alkB lipoyl-protein phosphoethanolamine MurNAc-pentapeptide kinase: aroK tetrahydrodipicolinate glycerol-phosphate cytidine crotonobetainyl- Ap3A oxidase: hydroperoxide acetyltransferase: acetyltransferase: tryptophan dehydrogenase: methyltransferase: malP synthetase: ligase: lipB (S)-3-methyl-2- asd N -carboxyaminoimidazole orotidine 5'-phosphate adenosine phosphoribosylformylglycinamide aldolase: eda tpiA reductase: protein 7''-transferase: eptB RzoR PqiC (2S)-2- O-acetyl-L-serine thiosulfate ribonucleotide nucleosidase: rihB CO2 acetate CoA synthetase: pgeF deglycase: speG speG synthase: yqhD rsmF aas oxopentanoate nucleoside triphosphate phosphorylase: deoD cyclo-ligase: purM dihydrolipoyltranssuccinylase: ahpC ahpF a [glycine-cleavage 2 2 shikimate isopropylmalate mutase: purE pyrophosphohydrolase: reductase: caiA lysU his208 hchA 8 trpA trpB 1407 α-D- 7-O-[2-aminoethoxy(hydroxy) H O UQH 4-hydroxy- imidazoleglycerol- glutathione PtsN- adenine 5-deoxy-D-ribose succinate formaldehyde dAMP a 2,3,4-saturated acyl-carrier protein complex6 H protein] α adenosine a nascent kinase: aroL hydro-lyase (2- cytidine mazG adenosine sucB tetramethoxy BglG-P PtsH a [protein]- an aliphatic N- N - Npr D-glyceraldehyde a 5-methylcytosine glucopyranose maltopentaose N -lipoyl-L-lysine phosphoryl]- -D-Kdo-(2->4) a 1,2-diacyl-sn-glycerol NRA isopropylmaleate- tetrahydrodipicolinate phosphate L-aspartate 4- orotidine-5'- nucleosidase: rihA 5'Ap3A azobismethylene (R)-lactate phosphorylated trp 3-hydroxypropionaldehyde 1-phosphate fatty acyl-[acp] -α-D-Kdo-(2->6)-lipid A IbsA CDP-glycerol O-phosphoethanolamine palmitoleate isoleucine L-homoserine AIR oxidized an alcohol L-cysteine acetyl-diamine acetylspermidine 3-phosphate in 16S rRNA 3'-GMP 2',3'-cyclic peptidoglycan forming): leuC leuD reductase: dapB dehydratase: hisB semialdehyde S-sulfo-L-cysteine phosphate DsbB quinine palmitoleoyl-[acp] transaminase: CAIR cytosine dUMP CDP- phosphoryl- (meso-DAP nitrateUQ shikimate 3-phosphate ilvE synthase: cysM decarboxylase: pyrF D-glyceraldehyde guanosine 3' monophosphate thioesterase: tesA YqiG adenosine 2'3'-cyclic endolytic murein YddL (S)-2,3,4,5- homoserine adenosine deaminase: add 3-phosphate glycerol ethanolamine containing) a palmitoleoyl-[acp] tetrahydrodipicolinate imidazole acetol-phosphate phosphoribosylaminoimidazole- cytosine thymidylate superpathway of pyrimidine nucleotidase: phosphodiesterase: transglycosylase: ABC-type 2-isopropylmaleate homoserine homoserine O- dehydrogenase: UMP deaminase: codA hydrolase: phosphatase: acyl-carrier protein a polymyxina polymyxin 3-phosphoshikimate 1- ile kinase: thrB metL superpathway of L-asparagine biosynthesis succinocarboxamide synthase: thyA nucleobases salvage Inorganic Nutrient Metabolism 1962 37 cpdB a mature a nascent bacitracin bacitracin tripartite succinyltransferase: S-sulfo-L-cysteine a reduced glutaredoxin synthase: purC glyceraldehyde- a 1,2-diacyl- RNase E YhaV endonuclease (S)-2- a peptide with a cytosine a [protein chain β-D-glucopyranose an adenine YafL ushA cpdB mltG carboxyvinyltransferase: metA tetrahydrodipicolinate histidinol-phosphate isopentenol a DNA segment trans-aconitate (R)-pantolactone β an L-phenylalanyl-Phe an N-terminal 3-mercaptopyruvate phoA peptidoglycan peptidoglycan a macrolidea macrolide antibiotic antibiotic efflux pump aroA UMP kinase: pyrH uracil dTMP 3-phosphate a protein sn-glycerol degradation degradation hydroxyglutarate an N-terminal PtsP- Npr in 23S rRNA elongation factor34 (R)- -lysine 1-phosphate [tRNA ] an acyl-[acyl-carrier protein] in tRNA sn-glycerol succinylase: dapD aminotransferase: inosine uracil dehydrogenase: substrate mRNA substrate mRNA L-alanine phosphorylated EF-P]-L-lysine L-lysyl-[protein] 2 cytidine ethanolamine (2S)-2- 5 guanosine 3'-AMP strand with (meso-DAP NmpC isopropylmalate hisC L-homoserine SAICAR gapA (aminomethyl)phosphonate degradation tRNA m A37 3-phosphate ElfC O-phospho- asp uracil superpathway of sulfate assimilation and cysteine biosynthesis L-2- alanyl trans-aconitate 2- 23S rRNA m C1962 EF-P-lysine β phenylalanyl- phosphate 5-enolpyruvoyl- hydro-lyase (2- N-succinyl- UDP dTMP phosphoribosyltransferase: upp methylphosphonate two-component alkanesulfonate monooxygenase serine isopentenol diacylglycerol recombinase: 2-dehydropantoyl- lysyltransferase: -phosphoglucomutase: tRNA--protein 3-mercaptopyruvate:cyanide methyltransferase: 1,6-anhydro- containing) with a ferric iron(III) L-homoserine 2-amino-6- S-sulfo-L-cysteine kinase: tmk degradation I kinase: thiM kinase: dgkA pinE ribonuclease: ribonuclease: hydroxyglutarate aminopeptidase: methyltransferase: lactone reductase methyltransferase: ycjU sulfurtransferase: sseA acyltransferase: plsX rlmN cis-vaccenoyl- hydroxamate a ferric shikimate 3-phosphate isopropylmaleate- cys O-succinyl-L- reductase: grxA inosine phosphorylase: ppnP Aromatic Compound Degradation protease: rne yhaV oxidase: lhgO pepN tam rlmI epmA transferase: aat MurNAc terminus GlcNAc terminus cis-vaccenate hydroxamate ABC hydroxamate forming): leuC leuD homoserine ketopimelate L-histidinol phosphate homoserine O- 5'-phosphoribosyl-4-(N- UMP lon YciQ [acp] complex complex dTDP inosine phosphorylase: xapA 13-DPG (aminomethyl)phosphonate 1962 [a protein chain Phe acyl-carrier protein an acyl phosphate a 2- 37 transporter L-isoleucine biosynthesis threonine succinyltransferase: succinocarboxamide) sulfate Npr 34 β L-phenylalanyl- chorismate N-succinyldiaminopimelate 3-phospho-D-glycerate an alkylsulfonate FMNH2 dimethylallyl a 1,2-diacyl- a DNA segment a peptide ala PtsP (E)-3- a 5-methylcytosine elongation factor EF- -D-glucose a tRNA methyladenine 5'-deoxyadenosine met thioesterase: tesA I (from threonine) synthase: metA L-aspartate:ammonia L-aspartate:L- -5-aminoimidazole UDP reductase: inosine phosphorylase: deoD UMP kinase: pyrH aminomethylphosphonate (methyl)phosphonate phosphate sn-glycerol in reverse an mRNA fragment an mRNA fragment 2-oxoglutarate phosphorylated (methoxycarbonyl) 2-dehydropantolactone in 23S rRNA P]-β-L-lysyl-L-lysine 6-phosphate L-lysyl-[protein] pyruvate in tRNA Slp synthase: (2R,3S)-3- thrC O-succinylhomoserine(thiol) aminotransferase: serC histidinol- ligase (AMP- lyase: purB N-acetyltransferase: phnO superpathway of 3-phenylpropanoate and 3-(3- a peptide a cis-vaccenoyl-[acp] HofQ aroC cys glutamine amido- nrdA nrdB dTDP phosphoglycerate phenylethylamine 3-phosphate orientation pent-2-enedioate n-hexane n-hexane isopropylmalate -lyase: metB phosphatase: hisB forming): asnB ligase (AMP- kinase: adk sulfate α-D-ribose 1- hydroxyphenyl)propanoate degradation acyl-carrier protein 3,6-diamino-10-methylacridinium chloride multidrug N-succinyldiaminopimelate O-succinyl-L- hypoxanthine UDP kinase: pgk (acetamidomethyl)phosphonate adenylyltransferase: D-3-phosphoglycerate degradation 3,6-diamino-10-methylacridinium chloride efflux pump thr cys homoserine forming): asnB dehydrogenase: serA methylphosphonate YhhN an an erythromycin erythromycin chorismate thr aminotransferase: argD AICAR dTDP cysD cysN 5-triphosphate AcrEF-TolC 3-isopropylmalate histidinol asparagine UDP kinase: adk deoxycholate deoxycholate L-cystathionine synthetase: asnA UDP kinase: adk kinase: ndk 3-phospho-D-glycerate synthase: phnL 2-phenylethylamine 3-phenylpropanoate 18 dehydrogenase threonine N-succinyl- dUDP hypoxanthine α phnH phnG phnI RNase G a peptide with α an [L-cysteine 32 UDP-N-acetylmuramoyl-L- a ring-opened 7- MlaA (decarboxylating) deaminase: L,L-2,6- UDP kinase: ndk UDP kinase: ndk -D-ribose-1-(2-N- 3-phosphooxypyruvate methylglyoxal a guanosine a 1,4- -D-glucan a cytosine a 10- an L-methionyl-Met UidC O-succinylhomoserine(thiol) AICAR phosphoribosyltransferase: gpt acetamidomethylphosphonate) APS a protein Ins(1)P enterobactin degradation L-allo-threonine oleoyl-CoA an N-terminal an acyl phosphate in tRNA cholate uroporphyrinogen-III glutathione S-sulfo-L-cysteine desulfurase]-S- alanyl-γ-D-glutamyl-meso-2,6- methylguanine in DNA a 1,2-diacyl- D-myo- a ribonucleoside L-alanyl-γ-D- a mature peptidoglycan (meso : dmlA ilvA diaminopimelate histidinol -lyase: metB dTTP α-D-ribose-1-(methyl) in tRNA formyltetrahydrofolate [initiator tRNA ] fructose- anthranilate chorismate asn transformylase: UTP -5-triphosphate synthase: 3-phenylpropionate substrate mRNA L-methionine sulfanyl-L-cysteine 32 diaminopimeloyl-D-alanine 2'-AMP sn-glycerol 3- inositol (2,5) 2',3'-cyclic glutamyl-L-lysyl- -diaminopimelate containing) D-fructose (2Z)-2-aminobut- dehydrogenase: hisD dUDP kinase: ndk hypoxanthine 2,3-bisphosphoglycerate- phosphonate- dioxygenase: hcaC glyoxalase maltodextrin DNA- D-fructose specific PTS synthase: mutase: tyrA cystathionine purH phosphoglycerate phnL phnH phnG phnI 3-phosphoserine 3-(3-hydroxyphenyl) acyl-CoA methionine α tRNA cytosine 2- L,D- 10-formyltetrahydrofolate:L-fMet EnvC peptidoglycan lytic 1-phosphate 2-enoate asn phosphoribosyltransferase: hpt independent adenylyl-sulfate 5-triphosphate phenylacetaldehyde hcaD hcaF hcaE III: yhbO inositol- enterochelin 3-hydroxy acid tRNA (Gm18) 2'-O- 7- -hydroxysteroid uroporphyrinogen-III reduced phosphorylase: formamidopyrimidine diphosphatediacylglycerol bisphosphate phosphate D-alanyl-D-alanine enzyme II trpE trpD 3-isopropylmalate β-lyase: malY succinyl- superpathway of L-alanine biosynthesis mutase: gpmA aminotransferase: serC alkanesulfonate FMN propanoate protease: ribonuclease: dehydrogenase: aminopeptidase: acylphosphatase: methyltransferase: dehydrogenase: C-methyltransferase: glutaredoxin malP sulfurtransferase: carboxypeptidase: methionyl-tRNA N- 2'AMP D-myo-inositol D-alanyl-D-alanine L-cystathionine dUTP CTP synthetase: pyrG phosphoglycerate kinase: cysC monooxygenase: reductase: phosphate esterase: fes dehydrogenase: ttcA glycosylase: mutM formyltransferase: fmt 2',3'-cyclic nucleotide endotransglycosylase: slt chorismate dehydrogenase: diaminopimelate histidinal mutase: gpmM α-D-ribose 1- ptrA glyoxalase: phosphatase: rng fadE map yccX trmH hdhA cysG 1: grxA ldcA pyrophosphate (2,5) bisphosphate carboxypeptidase: YddB desuccinylase: FAICAR α ssuD ssuE ydfG α 32 an [L-cysteine α an N-formyl- phosphatase: MipA mutase: pheA leuB cystathionine (acetamidomethylphosphonate) -D-ribose-1- 3-(3- 3-(5,6-dihydroxycyclohexa- hchA suhB -D- a 2-thiocytosine UDP-N-acetyl- -D-muramoyl- an apurinic site 2,6-diamino-4- 2'-phosphodiesterase: peptidoglycan lytic β dapE IMP methylphosphonate- a 2'-O- 18 α α glucopyranose α desulfurase]- γ L-methionyl-met phosphatase: phosphohydrolase: dacD multidrug -lyase: metC dUTP CTP 5-triphosphate PAPS 3-phospho-L-serine hydroxyphenyl) 1,3-dien-1-yl)propanoate N-(2,3- (2E,9Z)- a peptide met 3 ,12 -dihydroxy-7- sulfite cys GSSG a 1,4- -D-glucan in tRNA L-alanyl- -D-glutamyl- D-ala within DNA hydroxy-5-(N-methyl) a tetrahydrofolate phoA cpdB sodiumsodium dodecyl dodecyl sulfate sulfate anthranilate 3-methyl-2-oxobutanoate gln 5-triphosphate propanoate dihydroxybenzoyl) an mRNA fragment aminoacetone octadecenoyl-CoA a carboxylate methylguanosine oxo-5β-cholan-24-oate precorrin-2 1-phosphate L-cysteine meso-2,6-diaminopimelate formamidopyrimidine [initiator tRNA ] endotransglycosylase: emtA deoxycholate efflux pump (2S)-2-isopropyl- histidinal IMP pyrophosphohydrolase: 2-phospho-D-glycerate 2,3-dihydroxy-2,3- a peptide (R)-lactate myo-inositol in tRNA MgtS a 1,2-diacyl-pgpB appA D-alanyl-D-alanine deoxycholate MdtABC- 3-oxosuccinate dehydrogenase: hisD cystathionine cyclohydrolase: UTP nudI superpathway of pyrimidine diphosphatase: phnM hydroxylase: -L-serine a ribonucleoside peptidoglycan lytic Outer novobiocin novobiocin prephenate 2-iminobutanoate L,L- β-lyase: malY ribonucleotides de novo biosynthesis α-D-ribose-1-(2-N- phosphoadenosine mhpA dihydrophenylpropionate adenosine sn-glycerol Ins(2)P carboxypeptidase: Membrane TolC 2-aminoprop- diaminopimelate cys purH superpathway of pyrimidine ribonucleosides salvage acetamidomethylphosphonate) phenylacetaldehyde dehydrogenase: hcaB 3'-phosphate endotransglycosylase: mltD anthranilate 2-enoate valine transaminase: ilvE phosphosulfate phosphoserine α-D-ribose-1- dacAγ Protein phosphoribosyl L-homocysteine cystathionine deoxyuridine enolase: eno -5-triphosphate reductase: cysH phosphatase: serB methylphosphonate 3-phosphate L-alanyl- -D- YzcX Assembly L-cysteine:[protein pyruvate CTP synthetase: pyrG diphosphatase: phnM peptidoglycan lytic transferase: trpD his β-lyase: metC triphosphatase: dut cytidine 5-phosphate 516 1618 955/2504/ 2503 D-ala glutamyl-L- Complex prephenate prephenate diaminopimelate cysteine] gln hydrogencarbonate phenylacetaldehyde 1-deoxy- a negatively a DNA containing adenine endotransglycosylase: mltB glutamate--pyruvate a nucleoside thiamine DNA containing a uridine 7,8- adenine uridine a [release factor]- an L-phenylalanyl-Phe a [protein]- fosmidomycin Fsr epimerase: dapF sulfurtransferase: iscS IMP dehydrogenase: feaB D-xylulose a dipeptide an alkylated DNA an N-terminal 3-phosphooxypyruvate Sp methyl EssD lysyl-D-alanine fosmidomycin dehydratase: dehydrogenase: aminotransferase: alaC val CTP nucleoside triphosphate α-D-ribose-1-(2-N- sulfite ser diphosphate diphosphate a recognition site supercoiled DNA in 16S rRNA dihydroneopterin TsaD in 23S rRNA 2580 in 23S rRNA a peptide L-glutamine [tRNA ] arginyl-[protein] L-cysteine in 23S rRNA N-(5-phosphoribosyl) pheA tyrA 4-methyl-2- cobalamin- phosphoenolpyruvate acetamidomethylphosphonate) carbon- phosphotriester 2 peptidoglycan lytic -anthranilate oxopentanoate methionine 2-aminoprop- pyrophosphohydrolase: cytidine cytidine phosphorous topoisomerase: 6 5 2-oxobutanoate independent 5-phosphate an aldehyde FMN 2,3-DHP 1-deoxy- 955/ DNA-3- 23S rRNA m A2503 synthase: L-cysteine glutamate--pyruvate valine--pyruvate mazG carbamoyl phosphate deaminase: cdd kinase: udk lyase: phnJ phenylacetate nonspecific McrBC topB 16S rRNA 516 23S rRNA m A1618 23S rRNA proline protein-(glutamine-N phenylalanyl- methylphosphotriester- endotransglycosylase: mltC YiaD homocysteine 2-iminopropanoate meso- L-homocysteine 2-enoate desulfurase: sufS assimilatory D-xylulose nucleoside thiamin dihydroneopterin pseudouridine methyladenine 3-phosphohydroxypyruvate DNA-protein-cysteine S methyltransferase: a mature peptidoglycan strand a mature peptidoglycan RhsB transmethylase: metH diaminopimelate aminotransferase: alaA aminotransferase: avtA synthetase: carB carA pyruvate diphosphate dipeptidase: pyrophosphate restriction pseudouridine metallopeptidase: methyltransferase: aminopeptidase: ) methyltransferase: glycosylase: alkA tRNA--protein rlmN phosphoribosylanthranilate leucine sulfite reductase serine kinase: pepD endonuclease: synthase: rsuA epimerase: folB rlmF 2504/2580 pepP prmC transferase: aat phosphatase: nudL methyltransferase: ada ile ile 3-phenyl-2- 3-(4-hydroxyphenyl) acetohydroxybutanoate metE kinase: pykF carbon-phosphorous 2,3-dihydroxyphenylpropionate xylB kinase: ndk hydrolase: nudJ topoisomerase: tsaB 2503 with 1,6-anhydro-MurNAc terminus strand with GlcNAc terminus isomerase: trpC aminotransferase: dUMP phosphoenolpyruvate (NADPH): cysJ cysI acetyltransferase: cysE 5-phospho-α-D-ribose mcrB mcrC 6 synthase: rluC Phe val BrnQ val oxopropanoate pyruvate synthase: ilvG ilvM uridine CMP lyase: phnJ phenylacetate- 1,2-dioxygenase: mhpB topA 5 a DNA containing a DNA without Smp tyrB superpathway of L-aspartate CDP synthetase: ppsA 1,2-cyclic phosphate 955/ a proteinogenic an alkylated L-phenylalanyl-L- a [protein]-S- p a 2-methyladenine leu leu diaminopimelate cobalamin- inosine 5'- carbamoyl phosphate asp pyruvate CoA ligase: paaK a 16S rRNA 516 7,8- an N - 1618 a peptide a [release factor]-N an apurinic/ a tRNA S methyl 5'-deoxyadenosine met and L-asparagine biosynthesis methionine monophosphate 1-deoxy-D- a nucleoside a proteinogenic thiamine TsaD degradation methyladenine a pseudouridine amino acid nucleobase apyrimidinic site arginyl-[protein] hydroxypyruvate methyl-L-cysteine phosphotriester in 23S rRNA 1-(o- acetohydroxybutanoate decarboxylase: lysA independent thymidylate kinase: pykA amino acid Cleaved DNA a relaxed DNA pseudouridine dihydromonapterin -methyl-L-glutamine ω phenylalanine tyrosine methionine synthase: dehydrogenase: CDP reductase: synthase: thyA CMP kinase: cmk 5-phospho-α-D-ribose hydrogen sulfide O-acetyl-L-serine (2Z,4E)-2-hydroxy-6- xylulose 5- triphosphate phosphate products in 23S rRNA 2504/2580 in 23S rRNA 2-deoxy-D- a mature peptidoglycan(n) YfaL carboxyphenylamino) leucine synthase: ilvI ilvH synthase: homocysteine uridine α PRPP biosynthesis II phosphate guanosine 2'- N - dCMP LolB -1'-deoxyribulose transaminase: aminotransferase: metH 2-iminopropanoate guaB nrdA nrdB 1,2-cyclic phosphate 5-phospho- -D-ribosyl phenylacetyl-CoA oxonona-2,4-diene-1,9-dioate Ins(1,2,3,4,5,6)P6 ilvE aspC transaminase: metH pyruvate transmethylase: ala nucleosidase: rihB 1,2-cyclic phosphate thiosulfate disproportionation glucose 6- (meso-DAP containing) 5'-phosphate ilvE (S)-2-aceto-2- glu metE dTMP uridine pyruvate IV (rhodanese) monophosphate phosphocreatine dCMP phosphatase: phoA peptidoglycan lytic TyrP lys dCDP aspartate kinase: udk CDP phosphodiesterase: TufA phosphate D-myo-inositol tyr tyr hydroxybutanoate carbamoyltransferase: uridine 5-phospho-α-D-ribosyl cysteine synthase: cysM phnP D-ribose 5- 2-hydroxy-6- 2-deoxy-D- 2'GMP creatine phosphate dCMP exotransglycosylase: mltF phosphate 38- 1402 hexakisphosphate phenylalanine tyrosine alanine racemase: dadX pyrB pyrI nucleosidase: rihA 1,2-cyclic phosphate phenylacetyl- ketonona-2,4- indole-3- met dCDP kinase: adk dTMP kinase: tmk O-acetylserine gln succinate a uridine a cytidine a 5' triphospho- 3-(3,4-dihydroxyphenyl) a double 3-hydroxypropionaldehyde glucose 6- phosphatase: phosphoamidase: phosphohydrolase: yfbR transaminase: aminotransferase: leu aspartate methionine phosphodiesterase: phnP α-D-ribose 1,5- thiosulfate CoA 1,2- dienedioate cinnamate and 3-hydroxycinnamate an aromatic long chain riboflavin an acyl-CoA H2O 2,3- 3-oxo-(5Z)-dodecenoyl-CoA phosphohydrolase: peptidoglycan lytic YraP glycerol aspC tyrB (R)-2,3-dihydroxy-3- + transaminase: alanine racemase: alr sulfhydrylase: cysK α-D-ribose 1,5- hydrolase: mhpC Tap GTP AMP amino acid mutated tRNA polyphosphate semialdehyde 40 in tRNA ser in 16S rRNA diaminopropanoate [mRNA] pyruvate stranded DNA SAM TdcE phosphate phoA RsxG phosphate methylpentanoate:NADP synthase: dCDP kinase: ndk uracil uridine phosphomutase: epoxidase: degradation to 2-hydroxypentadienoate phoA 5'-deoxyribonucleotidase: exotransglycosylase: slt ile branched chain ile aspC metH pyruvate XMP dTDP UMP phosphoribosyltransferase: upp nucleosidase: rihC bisphosphate deoB thiosulfate- paaE paaA flavin 4 acyl-CoA acetyl-CoA C- D-myo-inositolappA synthase: trpC oxidoreductase CDP kinase: adk α sulfurtransferase: ygaP 38- exodeoxyribonuclease pyruvate formate- phosphatase: ushA val amino acid / val dCTP -D-ribose 1,5-bisphosphate α paaC paaB protein- AMP aromatic- reductase: cysJ succinate tRNA 16S rRNA m C1402 thioesterase: tesB RNA hydroxyphenyllactate acyltransferase: fadI 3-hydroxypropionaldehyde YtfL peptidoglycan lytic leu phenylalanine leu phenylalanine (isomerizing): ilvC D-ala N-carbamoyl-L-aspartate -D-ribose- (2Z)-2-hydroxypenta- RNase BN polyphosphate semialdehyde pseudouridine 3-hydroxy acid methyltransferase: 2,3- pyrophosphohydrolase: lyase activating guanosine creatine (1,2,3,4,5)- tyr CDP kinase: ndk 1-phosphate trans-cinnamate glutamine kinase amino-acid ribonuclease: kinase: ppk dehydrogenase: diaminopropionate dehydrogenase: hcxB V: recD recC recB dehydrogenase: puuC enzyme: pflA 2-deoxy- phoA 2'-deoxyribonucleoside exotransglycosylase: emtA phe ABC transporter phe aminotransferase: asp dTDP kinase: adk UMP kinase: pyrH uracil cys thiosulfate 2,4-dienoate glutaminase: (GTP): adk transaminase: riboflavin reductase: yihU 40 synthase: truA rsmH acyl-CoA rppH 3-ketoacyl-CoA pentakisphosphate (1S,2R)-1-C-(indol-3- tyrB met rbn ydfG 4 ammonia-lyase: ygeX MdtQ (R)-2,3-dihydroxy- ribose 1,5-bisphosphate cyanate degradation sulfurtransferase: sseA 2-(1,2-epoxy-1,2- cheB tyrB reductase: fre 38- thioesterase: yciA thiolase: fadA activated 2-ketobutyrate D-glucose 5'-monophosphate peptidoglycan lytic GfcD yl)glycerol 3-phosphate xanthosine-5'- dTDP kinase: ndk ribose 1- an N - 1402 3-methylpentanoate UDP phosphokinase: phnN dihydrophenyl) 2-oxopent- ADP GDP a pseudouridine a 5'-phospho- (R)-3-(3,4- formate-lyase / pyruvate 5'-deoxyadenosine phosphatase: aphA phosphate:L- dihydroorotase: pyrC phosphokinase thiosulfate acetyl-CoA cinnamate glu an aromatic a nucleoside 5'- long chain 4-hydroxybutanoate 40 in tRNA 2-aminoacetaldehyde methylcytidine pyruvate [mRNA] dihydroxyphenyl)lactate a 5'-phosphooligonucleotide 3-hydroxypropanoate formate-lyase 4 exotransglycosylase: mltD leucine / L- glutamine 4-enoate dioxygenase: Tap monophosphate polyphosphate reduced riboflavin a carboxylate (3Z)-dec-3-enoyl-CoA acetyl-CoA leu phenylalanine leu phe hydrogen sulfide sulfurtransferase: glpE hydratase: mhpD 2-oxo-acid in 16S rRNA YbjM 2'-deoxycytidine peptidoglycan lytic indoleglycerol 2,3-dihydroxy-3- aspartate L-aspartate:ammonia amido- dTTP UDP kinase: adk 2 hcaC hcaD phe ABC transporter phe phosphate asp PRPP CO biosynthesis I methylvalerate ammonia- ligase (AMP- Aminoacyl-tRNA Charging ligase (AMP- α-D-ribose 1,5- thiocyanate sulfite ring 1,2- hcaF hcaE exotransglycosylase: mltC aldolase: trpA hydro-lyase: ilvD lyase: aspAasparaginase: forming): guaA (S)-dihydroorotate UDP kinase: ndk superpathway of guanine and guanosine salvage carbonic bisphosphate (S)-4-hydroxy- RhsD iaaA forming): asnB epoxyphenylacetyl- NlpD L-glutamate anhydrase: CoA isomerase 2-oxopentanoate [+ 2 isozymes] UTP adenine cynT 2030 1207 (n) biosynthesis III tRNA charging adenylosuccinate phosphoribosyltransferase: apt cys (oxepin-CoA (2E)-3-(5,6- (3R)-3- GlcNAc-1,6-anhMurNAc- a mature peptidoglycan (S)-3-methyl-2- L-asparaginase: dihydroorotate gln 5-oxo-L-proline (5Z)- (S)-2- 4-hydroxy- adenine a guanine a 23S1911/1915/1917 rRNA a [ribosomal protein a 5-(carboxymethoxy)34 [(S)-1- a 5-(methoxycarbonylmethoxy)34 trp trp ser indole asparagine synthetase: purA ribose 1,5- forming): paaG dihydroxycyclohexa- hydroxybutanoyl- D-cysteine L-kynurenine in 16S rRNA uridine 3-oxo-(7Z)-tetradecenoyl-CoA γ Mtr oxopentanoate ansA synthetase: dehydrogenase: pyrD CTP bisphosphate 4-hydroxy-2- 1,3-dien-1-yl) Tsr lys tetradecenoyl-CoA hydroxyglutarate L-threonine in 23S rRNA L3]-L-glutamine uridine in tRNA 3-chloro-D-alanine thioglycolate aminoethyl]phosphonate uridine in tRNA YtfF L-Ala- -D-Glu-DAP-D-Ala (meso-DAP containing) indole indole fumarate GMP xanthine and xanthosine salvage synthetase: pyrG guanosine cysteine oxovalerate CoA 2-oxoglutarate asnA PRPP transaminase: aspC phosphokinase: prop-2-enoate 6 2 5 3-ketoacyl-CoA orotate diphosphate aldolase: mhpE 5-oxoprolinase: acyl-CoA 2-oxoglutarate 23S rRNA m A2030 16S rRNA m G1207 23S rRNA 1911/ protein-glutamine N- tRNA cmo U34 3-chloro-D-alanine (S)-1- tRNA (5- isoleucine arg phnN taurine degradation IV 2-oxepin-2(3H)- protein- crotonyl- lysine 2,3- D-cysteine kynurenine- pseudouridine thiolase: fadA α YejO tryptophan glutamate transaminase: adenylo-succinate 3-mercaptopyruvate cis-3-(2- glutamine CoA desulfhydrase, pxpC dehydrogenase: reductase ((S)-2- 4-hydroxythreonine methyltransferase: methyltransferase: methyltransferase: methyltransferase: dehydrochlorinase: aminoethylphosphonate methoxycarbonylmethoxyuridine) -D- D-myo- a 2'- peptidoglycan YfcU synthase: trpB arginine--tRNA ylideneacetyl-CoA 3-hydroxy- aminomutase: pxpB pxpA oxoglutarate fadE hydroxyglutarate- rlmJ rsmC 1915/1917 cmoM dcyD 3'-UMP dehydrogenase: ilvE guanylate carbamate hydrogencarbonate trans-cinnamate carboxyethenyl) glutaminase: hydratase: PLP-dependent: transaminase: kinase: thrB prmB acetyl-CoA C- N-acetyltransferase: phnO -ribose methyltransferase: trmL glucopyranose inositol (2,4,5) glycosyltransferase: ligase: argS diphosphate cyanase: acetaldehyde -3,5- epmB forming): serA 6 2 synthase: rluD 3-phospho-L-serine deoxyribonucleoside gdhA an L-arginyl-Arg xanthosine PRPP cheB paaZ dcyD aspC acyltransferase: fadI taurine ABC phe PheP phe asn kinase: gmk orotate guanosine phosphatase: phoA cynS oxepin-CoA cyclohexadiene- 1911/ S-carboxymethyl- taurine taurine 3'UMP adenylosuccinate 3-mercaptopyruvate taurine (2E,5Z)- an N - 2030 an N - 1207 a [ribosomal5 protein L3]- a 5-(methoxycarbonylmethoxy)34 [(1S)-1- a 5-(methoxycarbonylmethoxy)34 transporter 1-phosphate trisphosphateD-myo-inositol 3-phospho-L-serine 5'-monophosphate lpoA mrcA [tRNA ] phosphoribosyltransferase: CTP phosphorylase: ppnP 3-hydroxy- glu 4-phosphooxy- a pseudouridine D-cysteine glucose-1- 2'-deoxyribonucleoside Arg lyase: purB xanthosine sulfurtransferase: hydrolase: 1,2-diol glu 4-(2-aminophenyl)- tetradecenoyl-CoA 2-oxoglutarate methyladenine methylguanine N -methyl-L-glutamine uridine in tRNA (5Z)-dodecenoyl-CoA acetyl-CoA acetamidoethyl]phosphonate -2'-O-methyluridine in tRNA trp glu ile a tRNA pyrE inorganic sseA α-ketoglutarate- paaZ acetaldehyde trans- dehydrogenase: Tsr crotonyl-CoA (R)-β-lysine pyruvate L-threonine in 23S rRNA in 16S rRNA 1915/1917 in 23S rRNA phosphatase: (2,4,5) triphosphate phosphatase: phoA lipid II (meso peptidoglycan YfeN phosphorylase: ppnP guanosine guanosine dehydrogenase cinnamate 2,4-dioxobutanoate phosphatase: 5'-monophosphate EcnB GDP adenine and pyrophosphatase: ppa dependent taurine hcaB phoA phosphohydrolase: 3-phosphoserine diaminopimelate glycosyltransferase: adenosine kinase: gsk phosphorylase: xapA dioxygenase: tauD 3-oxo-5,6- (acetylating) hydroxylase: agp phosphatase: aphA xanthosine CO2 mhpA uridine 3' a peptide a peptide AMP salvage V cyanate hydrogen sulfide didehydrosuberyl- : mhpF D-myo- appA phosphatase: aphA containing) mrcB lpoB SbmA phosphorylase: xapA guanosine phosphate 2-aminoacetaldehyde YeaY phosphosugar 5'-deoxyribonucleotidase: antibiotic antibiotic orotidine 5'-phosphate guanine CoA semialdehyde 2445 nucleotidase: peptidoglycan xanthine phosphorylase: deoD 34 ω CMP a pyrimidine phosphatase: inositol (2,5) ser ushA a nascent phosphoribosyltransferase: hpt gln type-1 (R)-2- a guanine a precursor of [(R)-1- acetyl-CoA a cytidineIle2 lys an oligopeptide an N -(1- cis-vaccenoyl-CoA ribonucleotide S-methyl-L- 3-oxo-(11Z)-octadecenoyl-CoA 3-oxo-(9Z)-hexadecenoyl-CoA cpdB bisphosphate glycosyltransferase: Trg transmembrane hydroxyglutarate 2 in 23S rRNA large subunit of L-homocysteine aminoethyl]phosphonate SAM PflB phoA peptidoglycan BhsA cys adenylate adenine salvage pathways of pyrimidine ribonucleotides 3-oxo-5,6- dGMP in tRNA hydroxy-2- ATP H O methionine uridine deoxyribonucleoside di-trans,octa-cis YbgQ Fatty Acid and Lipid Biosynthesis xanthine orotidine-5'-phosphate guanine proteins oxopropyl) pyrimidine- 2 hydrogenase 3 3-ketoacyl-CoA 3-ketoacyl-CoA pbpC cysteine--tRNA kinase: adk decarboxylase: pyrF dehydrosuberyl- Ile pyrimidine- D-glucopyranose 5'-monophosphate with (L-alanyl- multidrug adenosine phosphoribosyltransferase: gpt phosphoribosyltransferase: gpt CoA semialdehyde protein- tRNA - oligopeptidase: -[protein]- acyl-CoA 2-oxoglutarate 5'-nucleotide 23S rRNA m G2445 hydrogenase homocysteine S- thiolase: fadA thiolase: fadA (R)-1- pyruvate formate- -undecaprenyl a gentamicina gentamicin efflux pump ligase: cysS GDP 2,3-dihydroxy- rhomboid dehydrogenase: reductase ((R)-2- ATPase: ychF methyltransferase: 5'-nucleotide 3 maturation methyltransferase: aminoethylphosphonate lyase activating Bcr γ an L-cysteinyl-Cys phosphorylase: cytidine GMP guanine dehydrogenase: glutamine lysidine ptrB L-arginine nucleosidase: nucleosidase: a drug a drug phosphatase: yfbR -D-glutamyl- diphosphate AcrAD-TolC GDP reductase: UMP trans-cinnamate protease: deoxyguanylate fadE hydroxyglutarate- ppnN rlmL protease: hycI mmuM N-acetyltransferase: phnO enzyme: pflA a 2'- palmitate biosynthesis [tRNA ] kinase: adk 2'-deoxyguanosine 5'-nrdA nrdB ppnP paaZ glutaminase: glpG synthetase: protein ATPase: ravA ppnN acetyl-CoA C- acetyl-CoA C- meso-2,6- superpathway of lipopolysaccharide biosynthesis superpathway of phospholipid biosynthesis I (bacteria) Cys kinase: gmk forming): serA 2 II (bacteria and plants) superpathway of unsaturated diphosphate:oxidized ADP cheB tilS deglycase: + a C terminal acyltransferase: fadI acyltransferase: fadI deoxyribonucleoside BglH a tRNA XMP 2,3- 2445 a large subunit activated pyruvate- Tsx fatty acids biosynthesis (E. coli) NrdH glutaredoxin-like cytidine 34 hchA (2E,11Z)- phosphate ADP an N - 32 amino- met [(1R)-1- met 5'-deoxyadenosine diaminopimeloyl- a nucleoside a nucleoside GDP cytidine dihydroxycinnamate glu cleaved type-1 D-ribofuranose H D-ribose 5- of hydrogenase 3 formate lyase protein oxidoreductase: adenosine UMP kinase: pyrH cytosine 3-oxo-5,6- a lysidineIle2 a peptide a [protein]- octadecenoyl-CoA 2-oxoglutarate cytosine methylguanine a pyrimidine base acid peptide palmitoleoyl-CoA acetyl-CoA (7Z)-tetradecenoyl-CoA acetyl-CoA acetamidoethyl]phosphonate ferric a (3R)-3- kinase: ndk deaminase: kinase: udk didehydrosuberyl- dioxygenase: mhpB Trg transmembrane (R)-lactate 5-phosphate in 23S rRNA phosphate deoxycholate D-alanyl-D-alanine) iron(III) iron(III) DHAP nrdE nrdF phosphorylase: anhydromuropeptides recycling I Secondary Metabolite Degradation proteins dGDP in tRNA L-arginine deoxycholate citrate ABC an acetoacetyl-[acp] a (3R)-3- UDP-N-acetyl- hydroxytetradecanoyl- deoD cdd D-galactonate degradation curcumin degradation CoA fosfomycin MdtG fosfomycin dicitrate dicitrate hydroxydecanoyl- [acp] 2'-deoxyadenosine 5'- UDP (2Z,4E,7E)-2- a drug a drug pentapeptide transporter α-D-glucosamine CMP acetoacetyl-[acp] [acp] diphosphate:oxidized ADP adenosine hydroxy-6-oxonona- YaiO glycerol-3-phosphate NrdH glutaredoxin-like reductase: UDP kinase: adk uridine pyrimidine nucleobases salvage II GlcNAc-1,6- 3-oxo-5,6- a long-chain FadL a long-chain reductase: fabG UDP-N- dehydrogenase: gpsA protein oxidoreductase: nrdA nrdB cytosine anhMurNAc- D-galactonate dehydrosuberyl- 2,4,7-triene-1,9-dioate fatty acid fatty acid putative 3-hydroxydecanoyl- gln UDP kinase: ndk CMP curcumin a (3R)-3- acetylglucosamine nrdE nrdF deaminase: L-Ala-γ-D-Glu- CoA 1835 34 peptidoglycan DD- multidrug [acp] acyltransferase: lpxA glutamine--tRNA adenosine pyrimidine deoxyribonucleotide gln codA kinase: an (aminoalkyl)phosphonate an (aminoalkyl)phosphonate hydroxybutanoyl-[acp] dGDP DAP-D-Ala D-galactonate NADPH-dependent thiolase: paaJ 2-hydroxy-6- gln 5-dehydro- (7Z)- (2-aminoethyl) α a guanine (S)-3-hydroxy-(9Z) di-trans,octa-cis a 5-carboxymethylaminomethyluridineLeu PhnCDE sulfadiazinesulfadiazine efflux pump dehydrase: fabA ligase: glnS deaminase: phosphorylation UTP cmk cytosine (2E,6E)-farnesyl an oligopeptide a nucleoside 3',5'- 2-dehydro-3- GDP- -D-glucose 6-decylubiquinol hydrogen (Z)-3-ureidoacrylate a double stranded DNA α an alkylphosphonate an alkylphosphonate carboxypeptidase: sn-glycerol 3-phosphate an L-glutaminyl-Gln dehydratase: curcumin oxononatrienedioate Tar L-homoserine 4-deoxy-D- tetradecenoyl-CoA deoxy-D-gluconate phosphonate in 23S rRNA peroxide peracid -octadecenoyl-CoA UDP- -D-glucose -undecaprenyl in tRNA curli MdtNOP GTP ATP add dgoD hydrolase: mhpC glucuronate diphosphate bisphosphate phosphate ATP cob(II)inamide D-ribulose 5-phosphate UDP-3-O-[(3R)-3- [tRNA ] dGDP uridine cytosine deaminase: codA reductase: curA 2 lpoA mrcA secretion Gln dTMP trans-2,3- GDP-glucose endonuclease: rpnA 3-hydroxyacyl-CoA YiaT ferric (3R)-3- hydroxymyristoyl]-N- kinase: adk dADP dCMP uridine kinase: udk CDP 2-dehydro-3-deoxy- farnesyl 3',5'-nucleoside acyl-CoA 2-keto-3-deoxy- (2-aminoethyl) glucosyl 23S rRNA m G1835 quinol:hydrogen peroxyureidoacrylate/ dehydrogenase: fadB tRNA (5- CsgA and CsgA (3R)-3- α a tRNA GTP ATP CTP synthetase: pyrG dihydrocurcumin dehydroadipyl-coA protein- homoserine 5-dehydro- oligopeptidase: undecaprenyl- peptidoglycan DD- assembly coprogen hydroxybutanoyl- hydroxydecanoyl- acetyl- -D-glucosamine dTMP dCMP phosphorylase: uracil 1,6-anhydro-N- superpathway of hexitol degradation (bacteria) D-galactonate (2Z)-2-hydroxypenta- glutamine diphosphate prlC bisphosphate dehydrogenase: D-gluconate phosphonate N- hydrolase: gmm methyltransferase: peroxide ureidoacrylate DNA phosphate glucose cobinamide carboxymethylaminomethyluridine) reductase: dGDP reductase: inosine ppnP acetylmuramoyl- 2,4-dienoate racemase: 4-deoxy-D- fadE dehydrogenase: acetyltransferase: rlmG oxidoreductase: amidohydrolase: rutB adenosyltransferase: -ribose methyltransferase: trmL complex ferric ferric outer [acyl-carrier [acyl-carrier D-arabinose acyl-CoA:sn-glycerol- acyl-acp:sn-glycerol- dADP kinase: tmk kinase: cmk CDP glutaminase: ygeA glucuronate phosphatase: phosphatase: endonuclease: ralR 3-hydroxyacyl-CoA phosphotransferase: CrcB carboxypeptidase: coprogen membrane protein] 5-phosphate UDP-3-O-acyl-N- 3-phosphate 1-O- 3-phosphate 1-O- nrdD kinase: ndk nrdD kinase: adk L-alanine 2,3- cheB bacA yciV kduD phnO 2 cydA cydB cydX btuR fluoride fluoride coprogen protein] kinase: ndk dTDP dCDP CTP uracil amidase: ampD 2-dehydro-3- NADPH-dependent isomerase: dehydrogenase: fadJ wcaJ mrcB lpoB transport dehydratase: fabZ dehydratase: fabZ isomerase: acetylglucosamine acyltransferase: plsB acyltransferase: plsB phosphoribosyltransferase: upp dehydroadipyl- (2E,7Z)- an N - 1835 (Z)-3- a 5-carboxymethylaminomethyl-34 Leu uridine UMP deoxygalactonokinase: dihydrocurcumin glu kduI D-glucopyranose GDP a 5'-phosphooligonucleotide hydrophilic hydrophilic complex deacetylase: lpxC CDP D-sorbitol 6-phosphate a peptide tetradecenoyl-CoA 3-deoxy-D-glycero- (2-acetamidoethyl) methylguanine 2 peroxyaminoacrylate α-D-glucopyranosyl- triphosphate adenosylcobinamide 2'-O-methyluridine in tRNA D-alanyl-D-alanine YehB gutQ inosine dgoK reductase: curA CoA hydratase: Tar D-homoserine (2E,6E)-farnesyl a nucleoside 5'- 2,5-hexodiulosonate phosphonate H O 6-decylubiquinone 3-oxo-(9Z)-octadecenoyl-CoA UMP OmpG dTDP dCDP phosphorylase: kinase: ndk UMP paaF 3-deoxy-D- phosphate monophosphate in 23S rRNA diphosphoundecaprenol solute < solute < ferric UDP-3-O-(3- kinase: gsk kinase: adk kinase: adk udp glycero-2,5- carboxypeptidase: 900 Da 900 Da citrate outer a (2E)-but-2-enoyl-[acp] a (2E)-dec- glu uracil β γ 2-dehydro-3-deoxy- iron(III) iron(III) membrane D-arabinose hydroxymyristoyl) a 1-acyl-sn-glycerol 3-phosphate a 1-acyl-sn-glycerol 3-phosphate CTP N-acetyl- -D- L-alanyl- -D- sorbitol-6- tetrahydrocurcumin hexodiulosonate a drug MdtL a drug dacA dicitratedicitrate 2-enoyl-[acp] -α-D-glucosamine glutamate--tRNA dTDP dCDP phosphoribosyltransferase: upp glucosamine-1,6- glutamyl-meso-2,6- phosphate 2- D-galactonate (3S)- Alcohol Degradation chloramphenicol chloramphenicol transport 5-phosphate ligase: gltX anhydro-N-acetyl- diaminopimeloyl- 6-phosphate hydroxyadipyl- D-alanyl-D-alanine an L-glutamyl-Glu kinase: ndk kinase: ndk dehydrogenase: D-mannitol 1-phosphate complex crotonyl-[acyl- isomerase: dGTP dATP IMP β-D-muramate D-alanine CoA hydrophilic hydrophilic OmpX kdsD acyl-CoA:1-acyl-sn- acyl-[acp]:1-acyl-sn- [tRNA ] srlD carboxypeptidase: solute or OmpN solute or carrier-protein] trans-2- UDP-3-O-(3- glu Amine and Polyamine Biosynthesis 2-dehydro-3-deoxy-6- 46 1516 glycerol-3-phosphate 2- glycerol-3-phosphate 2- dTTP dCTP uracil galactitol an oxidized glu 3-hydroxy-5- ion < 600 Da ion < 600 Da reductase: fabI hydroxymyristoyl) a tRNA mannitol-1- superpathway of glycol asp (7Z)- maltose a guanine a guanine (S)-3-hydroxy-(7Z) 2+ 2+ decenoyl- O-acyltransferase: plsC O-acyltransferase: plsC L,D- phosphogalactonate 3-hydroxyadipyl- glycerol and glycerophosphodiester degradation a signal peptide histidinol nitroaromatic phosphooxypentane- a primary alcohol hydroquinone glutathione 3-oxo-(7Z)-hexadecenoyl-CoA 2-oxepin-2(3H)-ylideneacetyl-CoA a [ribosomal protein89 dacD ACP glucosamine N- glcNAc-1,6- keto-D-fructose phosphate 5- metabolism and degradation CheB-P Tar hexadecenoyl-CoA in tRNA thr in 16S rRNA -tetradecenoyl-CoA a sulfurated [sulfur carrier] Ni2+ Ni 2+ D-xylose XylFGH D-xylose aldehydo-D-arabinose anhMurNAcaminidase: carboxypeptidase: 6-phosphate dehydrogenase: aldolase: dgoA CoA compound 2,4-dione S12] L-aspartate RcnA a nascent D-alanyl-D-alanine isomerase: acyltransferase: 7 2 alcohol 3-ketoacyl-CoA Co Co 5-phosphate superpathway of arginine and polyamine biosynthesis ldcA transport of mtlD dehydrogenase: signal maltose O- 3-hydroxyacyl-CoA a butanoyl-[acp] fabA lpxD nagZ paaH histidinal acyl-CoA tRNA m G46 L-threonine 16S rRNA m G1516 dehydrogenase: adhP hydroquinone:hydrogen S-adenosyl-L- dehydrogenase: fadJ thiolase: fadA oxepin-CoA hydrolase/3- protein peptidoglycan carboxypeptidase: glycine betaine D-galactitol: D-glyceraldehyde ethylene glycol peptide dehydrogenase NAD(P)H chemotaxis protein Autoinducer- dehydrogenase: acetyltransferase: methyltransferase: dehydrogenase: yiaY methyltransferase: peroxide methionine:glutathione oxo-5,6-dehydrosuberyl- methylthiotransferase: GfcE L-alanyl-γ-D- gatC 3-phosphate pyruvate a glycerophosphodiester peptidase: nitroreductase: 2 degrading YaiW superpathway of (Kdo)2-lipid A biosynthesis Cell Structure Biosynthesis biosynthesis I (Gram- 1,6-anhydro-N- / histidinol methyltransferase: fadE maa trmI rsmJ oxidoreductase: ccp methyltransferase: cheR CoA semialdehyde rimO with (L-alanyl- dacC ferrichrome UDP-2-N,3-O-bis[(3R)- peptidoglycan biosynthesis I (meso-diaminopimelate containing) negative bacteria) glutamyl-meso- gatB gatA rseP nfsB cheR protein: lsrG alcohol 3-hydroxyacyl-CoA acetyl-CoA C- dehydrogenase: paaZ outer β a (3Z)-dec- polymyxin resistance acetyl-β-muramate glycerophosphodiester dehydrogenase: 7 threonine 2 dehydrogenase: adhE dehydrogenase: fadB a [ribosomal protein γ -ketohexanoyl- 3-hydroxytetradecanoyl]- glu diaminopimelate 3-oxoadipyl-CoA glycolaldehyde phosphodiesterase: ugpQ hisD α acyltransferase: fadI an unsulfurated L-lyxopyranose L-lyxopyranose -D-glutamyl- [+ 2 isozymes] membrane [acp] 3-enoyl-[acp] α ile peptidoglycan maturation (meso-diaminopimelate containing) (2E,7Z)- 6-O-acetyl- -D- an N - 46 dehydrogenase: tdh an N - 1516 5'-deoxyadenosine met S12]-3-methylsulfanyl-89 RhaT D-ala ferrichromeferrichrome -D-glucosamine reductase: fucO a reduced glu-Me 3,4,4-trihydroxy-5- 1,4-benzoquinone S-methylglutathione [sulfur carrier] L-rhamnose D-arabinofuranose isoleucine--tRNA a (3R)-3- UDP-N-acetyl- choline nitroaromatic phosphooxypentan- hexadecenoyl-CoA glucopyranosyl- methylguanine methylguanine an aldehyde 3-oxo-(7Z)-tetradecenoyl-CoA acetyl-CoA (5Z)-tetradecenoyl-CoA 3-oxo-5,6-didehydrosuberyl-CoA L-aspartate L-rhamnose meso-2,6- transport synthase: fabB UDP-α-D- anhydro-N- galactitol 1-phosphate F6P glycerol CheB a peptide Tar (1->4)-D-glucose in tRNA aminoacetone in 16S rRNA complex 5-phosphate ligase: ileS UDP-N-acetyl- hydroxytetradecanoyl- α-D-glucosamine glycerophosphoryl diester compound 2-one diaminopimeloyl- 5 UDP-2,3- an L-isoleucyl-Ile α [acp] lipid II (meso glucuronate N-acetylglutamate acetylmuramic β-ketoadipyl- phosphodiesterase: glpQ his YhcD β-keto-cis-∆ a 1,2-diacyl-sn-glycerol 3-phosphate [tRNA ] -D-glucosamine choline CoA glycolaldehyde glycerol kinase: glpK Blc diacylglucosamine Ile diaminopimelate containing) synthase: argA acid kinase: D-alanyl-D-alanine) a 3-oxohexanoyl-[acp] -dodecenoyl- diphosphatase: lpxH UDP-N-acetylglucosamine dehydrogenase: anmK ketogluconate metabolism thiolase: + + 3-deoxy- a tRNA UDP-glucuronate betA galactitol-1- fructose-1,6- [acp] D-manno- 1-carboxyvinyltransferase: dehydrogenase: phosphate 5- paaJ pentapeptide Na NhaB Na synthase: UDP-N- murA peptidoglycan biphosphate glycolaldehyde YedA octulosonate CTP:phosphatidate glycosyltransferase: arnA betaine aldehyde N-acetyl-D- dehydrogenase: dehydrogenase: 3-oxoacyl-[ACP] fabB lipid X cytidyltransferase: cdsA acetylglucosamine N-acetyl-L-glutamate phosphatase: 37 2251 2069 8-phosphate lpoA mrcA muramate 6- gatD phoA 2,5-didehydro- aldA 6 a nascent reductase: fabG acyltransferase: lpxA succinyl-CoA (2E,5Z)- glu a 6,7- a guanine guanosine a guanine salicin 6- (Z)-2- (S)-3-hydroxy-(5Z) a DNA containing an YdeT synthase: kdsA UDP-N-acetyl-α- β phosphate D-gluconate sn-glycerol 3-phosphate asp576 an isocitrate palmitoleoyl-CoA 11-deoxycorticosterone 3-oxo-(9Z)-octadecenoyl-CoA a [protein]-L-cysteine an O -methylguanine in DNA HtrE D-ribulose UDP- -L-threo- betaine aldehyde ArcB-P HipA dodecenoyl-CoA a protein Tsr dihydropteridine in tRNA in 23S rRNA in 23S rRNA phosphate methylureidoacrylate -tetradecenoyl-CoA apurinic/apyrimidinic site peptidoglycan glycine a (5Z)-3- 5-phosphate D-glucosamine- pentapyranos- keto-D-tagatose dehydrogenase peracid oxododec- lipid A a CDP-diacylglycerol enolpyruvate peptidoglycan acetylglutamate dehydrogenase: dihydropteridine 1 7 3-hydroxyacyl-CoA 3-ketoacyl-CoA DNA-AP site O-6-methylguanine-DNA a peptidoglycan glycine betaine ABC glycine a (3R)-3- disaccharide 4-ulose kinase: argB betB 6-phosphate fructose-1,6- glycolate enoyl-CoA acyl-CoA tRNA m G37 23S rRNA 2'-O 23S rRNA m G2069 salicin 6- L,D with L,D cross 5-enoyl-[acp] leu glycosyltransferase: N-acetylmuramic serine/ hydratase: reductase: hmp peroxyureidoacrylate/ 11-deoxycorticosterone dehydrogenase: fadB thiolase: fadA lyase: nth methyltransferase: ada YpfN with (L-alanyl- betaine transporter, non- betaine hydroxyhexanoyl-[acp] KDO-8P synthase: lpxB UDP-3-O-[(3R)-3- mrcB lpoB acid 6- bisphosphatase: 2,5-diketo- glycerol-3-phosphate aerobic glycerol alanyl chemotaxis protein isocitrate dehydrogenase: methyltransferase: -ribose G2251 methyltransferase: phosphate transpeptidase: links (meso- osmoregulatory leucine--tRNA D-arabinose hydroxymyristoyl]- yggF 6-phosphofructokinase: dehydrogenase, 3-phosphate threonine fadJ aminopeptidase: methyltransferase: dehydrogenase methyltransferase: glucohydrolase: ureidoacrylate reductase: kduD 6 γ 5 α UDP-N- UDP-4-amino-4- phosphate D-gluconate kinase: fadE dihydropteridine trmD rlmL 3-hydroxyacyl-CoA acetyl-CoA C- DNA-AP site O -alkylguanine-DNA- -D-glutamyl- phosphatidylglycerophosphate phosphatidylserine ligase: leuS 5-phosphate N-acetyl- -D- acetylenolpyruvoylglucosamine N-acetylglutamyl- glycine betaine etherase: murQ pfkA reductase: glycolate anaerobic: glpA glpB glpC dehydrogenase: glpD pepN cheR kinase: aceK rlmB bglB amidohydrolase: rutB ldtE diaminopimelate YfaZ 3-oxo-cis-∆ - lipid A disaccharide an L-leucyl-Leu isomerase: glucosamine deoxy-L-arabinose dehydrogenase: hipA reductase: nfsB 1 7 dehydrogenase: fadJ acyltransferase: fadI lyase: nei alkyltransferase: ogt CsgF synthase: pgsA synthase: pssA reductase: murB peptidoglycan phosphate dkgA 2-keto-D- 37 2-O- 2069 meso-2,6- (3R)-3- dodecenoyl- (E. coli) [tRNA ] gutQ aminotransferase: fructose 1,6- glcD glcE glcF enoyl-CoA (2E,9Z)- an N - 2251 an N - 4-pregnen- containing) Leu glycosyltransferase: 6-phosphofructokinase: gluconate phosphorylated glu-Me a phosphorylated a 5,6,7,8- β-D-glucose (Z)-2-methyl- a 3'-terminal + + hydroxyhexanoyl- [acp] 3-deoxy- arnB N-acetyl-D- bisphosphatase: his717 hydratase: hexadecenoyl-CoA methylguanine methylguanosine methylguanine salicyl alcohol 20,21-diol-3-one 3-oxo-(5Z)-tetradecenoyl-CoA acetyl-CoA (7Z)-hexadecenoyl-CoA a 5'-phospho-[DNA] a guanine in DNA a [protein]-S-methyl-L-cysteine diaminopimeloyl- TrkH a tRNA ala pbpC D-tagatofuranose pfkB DHAP serine/threonine a peptide Tsr isocitrate tetrahydropteridine in tRNA in 23S rRNA 6-phosphate peroxyaminoacrylate unsaturated sugar AtpI K K [acyl-carrier reductase: D-manno- tetraacyldisaccharide UDP-3-O-acyl-N- UDP-N-acetyl- glucosamine 6-phosphate ybhA superpathway of hexuronide ArcB-P fadB dehydrogenase protein] fabG octulosonate acetylglucosamine α-D-muramate N-acetylglutamylphosphate 6-phosphate kinase HipA in 23S rRNA D-alanine) 4'-kinase: lpxK 1-(3-sn-phosphatidyl)- a 3-O-sn-phosphatidyl-L-serine D-arabinose UDP-4-amino- reductase: argC 2,5-diketo- and hexuronate degradation glyoxylate (S)-3-hydroxy-(5Z) dehydratase: fabZ 8-phosphate sn-glycerol 3-phosphate deacetylase: lpxC glu peptidoglycan 4-deoxy-β-L- D-gluconate tetrapeptide D-ala YdiY phosphatase: 5-phosphate tagatose-6- fructose-1,6- reductase: -dodecenoyl-CoA SlyB isomerase: glycosyltransferase: arabinopyranose N-acetylglucosamine- β glycerol degradation V a (3R,5Z)-3- kdsC lipid IVA UDP-3-O-(3- N-acetyl-L-glutamate phosphate bisphosphatase: dkgB a -D- phosphatidylserine kdsD UDP-N- mtgA 6-phosphate glpX + + hydroxydodec- phosphatidylglycerophosphatase: hydroxymyristoyl) acetylmuramate--L- 5-semialdehyde kinase: pfkB glucuronoside K Kup K a (2E)-hex-2-enoyl-[acp] 5-enoyl-[acp] pgpC decarboxylase: psd -α-D-glucosamine glutamate UDP-4-amino-4- deacetylase: nagA glyoxylate malate CvrA alanine ligase: murC racemase: carboligase: synthase 32 527 val a nascent peptidoglycan deoxy-L-arabinose fructose-1,6- 2,5-diketo- β glycerol 4 α-Kdo aldehydo-D- murI N-acetylornithine D-tagatofuranose -D- gcl G: glcB asp (2E,9Z)- glu an oxidized a uridine a guanine a CDP- a 5'-half-tRNA his15 (S)-3-hydroxy-(9Z) glutathione hexanoyl-[acyl- 3-deoxy- phosphatidylglycerophosphatase: valine--tRNA arabinose 5- with (L-alanyl-γ-D-glutamyl- formyltransferase: D-glucosamine 1,6-bisphosphate bisphosphatase: fbp D-gluconate 2-keto-D- glucuronidase: pre-crRNA octadecenoyl-CoA Ins(2)P diacylglycerol [DNA] a 3'-half-tRNA 2-hydroxy-dATP -hexadecenoyl-CoA a single stranded DNA 2-hydroxyethyldisulfide an O -methylthymine in DNA a [protein]-L-cysteine peptidoglycan DD- YjbH 3-hydroxy5 cis an L-1-phosphatidylethanolamine aminotransferase: fructose- 2-keto-L-gulonate KdpE-P met Trg hybrid- in tRNA in 16S rRNA molecule with dihydroxyacetone HPr-P EcpC D-manno- pgpB ligase: valS phosphate UDP-3-O-(3- meso-2,6-diaminopimeloyl-D- arnA 6-phosphate reductase: gluconate uidA glycerol molecule with 4 carrier-protein] ∆ -dodecenoyl- an L-valyl-Val hydroxymyristoyl) gabT bisphosphate ghrB cluster protein 7 a 2',3'-cyclic transpeptidase: a nascent octulosonic UDP-N-acetyl- alanyl-D-alanine) pentapeptide tagatose-1,6- β reductase: ethanol degradation I dehydrogenase: enoyl-CoA CDP- a 5'-OH end 3-hydroxyacyl-CoA single stranded 2-hydroxyethyldisulfide O -methylthymine-DNA 2+ 2+ [acp] [tRNA ] glucosamine N- α aldolase: fbaB -D-fructose 1,6- CRISPR RNA tRNA Um32 16S rRNA m G527 type I site-specific phosphate end oxidized nucleoside 3-deoxy-manno acid Val -D-muramoyl- D-glt tartronate gldA inositol dihydroxyacetone dehydrogenase: fadJ endodeoxyribonuclease: reductase: yghU methyltransferase: ogt lpoA mrcA peptidoglycan MntP reductase: fabI dehydratase: phosphatidylglycerophosphatase: L-alanine UDP-4-deoxy-4- phosphoglucosamine bisphosphate bisphosphate ghrB (S)-malate hydratase: L-amino acid N- chemotaxis protein NADH methyltransferase: methyltransferase: diacylglycerol deoxyribonuclease: 2'-5' RNA triphosphate YbhN Mn Mn -octulosonate transferase: pgpA a tRNA acyltransferase: β N-acetylornithine aldolase: 2-keto-L- D-glucopyranuronate semialdehyde processing: fadJ acyltransferase: monophosphatase: diphosphatase: pyrophosphohydrolase: kinase: dhaK recD recC recB a peptidoglycan fabZ cytidylyltransferase: waaA lpxD formamido- -L- mutase: glmM gulonate dihydroxyacetone casA casB methyltransferase: oxidoreductase: suhB trmJ rsmG hsdM hsdR hsdS ligase: dhaL dhaM 3-hydroxyacyl-CoA 2-hydroxyethyldisulfide O-4-methylthymine-DNA peptidoglycan DD- with D,D cross- arabinopyranose aminotransferase: gatY gatZ fructose ethanol mnaT cheR hcr cdh nudG with (L-alanyl- a hexanoyl-[acp] kdsB peptidoglycan DD- peptidoglycan DD- argD DHAP reductase: casC 7 thpR dehydrogenase: fadB deoxyribonuclease IV: nfo reductase: yfcG methyltransferase: ada transpeptidase: links (meso- SfmD an L-1-phosphatidyl-sn-glycerol transpeptidase: bisphosphate tartronate casD casE a 2'-O- 32 an N - 527 a double stranded OmpW D-arabinofuranose carboxypeptidase: α ghrB alcohol enoyl-CoA glu-Me a ligated tRNA PtsH DHAP γ-D-glutamyl- UDP-2-N,3-O-bis[(3R)- -D-glucosamine aldolase: fbaA semialdehyde dihydroxyacetone asp N-acetyl-L- myo-inositol methyluridine methylguanine a 1,2-diacyl- DNA with 5'- a (3E,5Z)-dodeca- 5-phosphate UDP-N- lpoA mrcA lpoA mrcA 1-phosphate dehydrogenase: adhE hydratase: Trg a reduced hybrid- CMP sn-glycerol with a 2'-5' linkage 2-hydroxy-dAMP 3-oxo-(9Z)-hexadecenoyl-CoA a 5'-phosphooligonucleotide GSSG 2-mercaptoethanol a [protein]-S-methyl-L-cysteine a thymine in DNA mrcB lpoB diaminopimelate CMP-Kdo α-Kdo-(2->6)-lipid IVA biotin-carboxyl carrier 3-hydroxytetradecanoyl]- undecaprenyl- hydrogencarbonate tagatose-1,6- triose- reductase: glxR kinase: dhaK KdpE-P fadB methionine cluster protein in tRNA in 16S rRNA terminal phosphate meso-2,6- β-ketooctanoyl- 3,5-dienoyl-[acp] α-D-glucosamine acetylmuramoyl- a mature peptidoglycan with -phosphate 3-phosphate containing) ethidium TehA ethidium protein assembly L-alanine--D- phosphate N-acetyl-L-ornithine bisphosphate phosphate L-idonate aldehydo-D- dhaL dhaM crRNA YjeO [acp] cardiolipin synthase: clsB peptidoglycan DD- (L-alanyl-γ-D-glutamyl-meso- aldolase: isomerase: ethanol (S)-3-hydroxy-(9Z) diaminopimeloyl- synthase: fabB 5 glutamate peptidoglycan DD- 4-deoxy-4- aldehydo-D- glucuronate ∆ ala 3-deoxy- transpeptidase: 2,6-diaminopimeloyl-D-alanyl- formamido- carbamoyl glucosamine- kbaY kbaZ tpiA (R)-glycerate dehydrogenase: adhP -octadecenoyl-CoA D-alanine) YpjA cis- -dodecenoyl- cardiolipin synthase: clsA a [biotin carboxyl- alanine--tRNA D-manno- UDP-2,3- ligase: murD carboxypeptidase: mrcB lpoB D-alanine) pentapeptide 1-phosphate L-idonate 5- galacturonate DHAP AppX [acp]:NAD+ octulosonate diacylglucosamine mrcB lpoB L-arabinose acetylornithine phosphate dehydrogenase: acetaldehyde D-ala carrier protein]-L-lysine ligase: alaS transferase: deacetylase: synthetase: acetyltransferase: D-glucuronate tetrapeptide M-antigen M-antigen a 3-oxooctanoyl-[acp] oxidoreductase: an L-alanyl-Ala 8-phosphate diphosphatase: lpxH glmU idnD isomerase: monomer monomer fabI [tRNA ] peptidoglycan D,D- arnC argE carB carA D-galacturonate glycerate WzxC a cardiolipin Ala synthase: kdsA D-alanyl-D-alanine isomerase: uxaC uxaC 2-kinase: 966 a [protein]-L- YfgO undecaprenyl undecaprenyl biotin- UDP-N-acetyl- transpeptidase: ftsI acetaldehyde an L-1- a protein-L- a damaged an oxidized glu a HypE hydrogenase D-galactosamine a cytidine a guanine UTP (S)-3-hydroxy-(7Z) a tRNA lipid X meso- carboxypeptidase: N-acetyl-α-D- glxK dehydrogenase 32 D-phenylhydantoin methyl red 2-dehydro-3-deoxy-D-arabinonate a single stranded DNA diphosphate diphosphate KDO [acetyl-CoA- α-D-muramoyl-L- D-glyceraldehyde phosphatidyl- methionine- DNA pyrimidine nitroaromatic Tap maturation protein- 6-phosphate in tRNA in 16S rRNA L-cystathionine -hexadecenoyl-CoA β-isoaspartate 3-oxoacyl-[ACP] a (5Z)-dodec- carboxylase] diaminopimelate dacA peptidoglycan DD- L-ornithine glucosamine 5-dehydro- (acetylating): mhpF sn-glycerol (S)-S-oxide compound UTP a tRNA precursor CTP ATP YfiB transferase: alanyl-D-glutamate carbamoyl phosphate D-tagaturonate D-fructuronate S-carboxamide 2 2-dehydro-3-deoxy-D- YjbF reductase: fabG 5-enoyl-[acp] KDO-8P 4-deoxy-4- 1-phosphate 3-phosphate D-gluconate DNA N- galactosamine- cystathionine 3-hydroxyacyl-CoA ssDNA-specific waaA ligase: birA transpeptidase: mrdA α glycerate NADPH- tRNA Cm32 16S rRNA m G966 pyrophosphatase: yhdE FMN dependent pentonate aldolase: yagE exonuclease: recJ L,D lipid A D-alanyl-D-alanine formamido- -L- 2-kinase: acetaldehyde lipid protein- glycosylase: chemotaxis protein [HypE]-S- 6-phosphate β-lyase: malY phenylhydantoinase: dehydrogenase: fadJ L-isoaspartate protein disaccharide nei dependent carboxamide methyltransferase: methyltransferase: NADH- tRNA adenylyl- carboxylmethyltransferase: pcm carboxypeptidase: D-xylose XylE D-xylose carboxypeptidase: arabinopyranosyl glyceraldehyde- 5-keto-D- tagaturonate D-mannonate garK dehydrogenase: adhE kinase: methionine- methyltransferase: deaminase/ trmJ rsmD nucleoside triphosphate hyuA azoreductase: /cytidylyl- YpdI a (3R)-3- 3-oxo-cis-∆7- a [biotin carboxyl- synthase: lpxB D-ala ditrans,octacis N-acetylglucosamine- reductase: oxidoreductase: yegS S-oxide nitroreductase cheR dehydratase: isomerase: agaS 3-hydroxyacyl-CoA 2-dehydro-3-deoxy-D- exodeoxyribonuclease dacD 3-phosphate gluconate 5- 2 cystathionine pyrophosphohydrolase: azoR transferase: cca ldtE hydroxyoctanoyl-[acp] tetradecenoyl- carrier6 protein]-N UDP-N- a nascent peptidoglycan -undecaprenyl ornithine 1-phosphate uxaB uxuB reductase: NfsA: nfsA hypE β dehydrogenase: fadB pentonate aldolase: yjhH VII: xseA xseB -biotinyl-L-lysine 3-deoxy- uridyltransferase: dehydrogenase: reductase: 2-phospho- DNA a 2'-O- 32 an N - 966 -lyase: metC mazG a tRNA containing a protein L-β- [acp] asn lipid A acetylmuramoyl- with D,D cross-links (meso- phosphate carbamoyltransferase: gapA acetyl-CoA 1-(3-sn- msrA a reduced glu-Me D-tagatofuranose N-carbamoyl-D- L, D OmpA asparagine--tRNA D-manno- L-alanyl-D- diaminopimelate containing) argF glmU idnO D-glycerate glycosylase: a HypE hydrogenase methylcytidine methylguanine N,N-dimethyl-1,4- anthranilate a 3' CCA end 3-oxo-(7Z)-hexadecenoyl-CoA isoaspartate glycolaldehyde a single-stranded a ribonucleoside RzoD synthase: fabB octulosonate disaccharide D-alanyl-D-alanine phosphatidyl) nitroaromatic Tap maturation 6-phosphate in tRNA in 16S rRNA L-homocysteine pyruvate phenylglycine phenylenediamine α pyruvate carboxypeptidase: (3R)-3- ligase: asnS (E. coli) D-alanine--D- glutamate--2,6- carboxypeptidase: D-altronate D-mannonate nth compound UMP -methyl ester oligodeoxyribonucleotide 5'-monophosphate an L-asparaginyl-Asn 8-phosphate alanine undecaprenyl -sn-glycerol a [protein]-L- protein-S-cyanate cetylpyridinium cetylpyridinium hydroxyoctanoyl- α-Kdo-(2->4)-α- diaminopimelate dacC UDP-N-acetyl- 3-phosphate methionine ldtC guanidinium Gdx guanidinium a (7Z)-3- [tRNA ] phosphatase: ligase: ddlB ligase: murE phosphate- ornithine 13-DPG an apyrimidinic YfbS [acyl-carrier Kdo-(2->6)-lipid IVA Asn kdsC α-L-ara4FN α-D-glucosamine D-altronate D-mannonate site in DNA protein] oxotetradec- tRNA tetraacyldisaccharide carbamoyltransferase: L,D 7-enoyl-[acp] a [biotin carboxyl- 4'-kinase: lpxK [+ 2 isozymes] deformylase: argI dehydratase: dehydratase: a nascent RcsF dehydratase: fabZ uxaA uxuA carboxypeptidase: MliC lauroyl carrier-protein6 dimer]- D-alanine- a mature peptidoglycan arnD UDP-N-acetylglucosamine 7 phosphoglycerate peptidoglycan acyltransferase: N -biotinyl-L-lysine α D-alanine with D,D cross-links (meso- 1-carboxyvinyltransferase: a nascent ldtB 3-oxo-cis-∆ - -Kdo lipid IVA kinase: pgk 37 745 1915 3 with (L-alanyl- tetradecenoyl- lpxL ligase: UDP-N-acetyl- a nascent peptidoglycan diaminopimelate containing) 4-amino-4- murA (2E,7Z)- an [RNA]-3'- a phosphorylated L-glyceraldehyde adenine a guanine a pseudouridine an N -methyladenine a 2,3,4-saturated H2 HYD1 MQH2 ddlA α with (L-alanyl-γ-D-glutamyl- α D-alanyl-D-alanine val an [RNA]-3'- ADP-D-ribose NADH a 2-oxo an S-sulfanyl-[L- a [disordered-form [Fe-S] PdeB peptidoglycan L,D- a (2E)-oct-2-enoyl-[acp] [acp] acetyl-CoA biotin -D-muramoyl- deoxy- -L- L-citrulline BtsR 3',5'-ADP tetradecenoyl-CoA ribonucleoside- isocitrate 3-phosphate in tRNA1 in 23S rRNA ribunucleoside- in 23S rRNA in DNA met CTP 1,2-diacyl-sn- γ-D-glutamyl- α carboxyltransferase: carboxylase: L-alanyl-γ-D- meso-2,6-diaminopimeloyl- arabinopyranosyl α D-alanyl- 3'-phosphate carboxylate glycerol 3-phosphate dGTP cysteine desulfurase] cluster scaffold protein] with (L-alanyl- carboxypeptidase: reductase: fabG -Kdo-(2->4)- 3-deoxy-manno UDP-N-acetyl- - 3-phospho-D-glycerate 2-dehydro- dehydrogenase 6 1 2',3'- 3 α-Kdo-(2->6)- accA accD accC glutamyl-meso-2,6- D-alanine) tetrapeptide ditrans,octacis D-glucosamine- D-gluconate enoyl-CoA ADP-ribose NADH meso-2,6- OmpL asp -octulosonate α-D-Kdo-(2->4) 3-deoxy-D- 3'(2'),5'- D-alanine RNA 3'- isocitrate L-glyceraldehyde tRNA m A37 23S rRNA m G745 cyclophosphate pyrophosphatase: 23S rRNA m Ψ1915 3 methyl- methionine- scaffold γ-D-glutamyl- ldtA RlpA octanoyl-[acyl- (lauroyl)-lipid IVA cytidylyltransferase: D-alanyl-D-alanine diaminopimelate -undecaprenyl enolpyruvate hydratase: 3-phosphate pyrophosphatase: adenine DNA CTP:2,3,4-saturated dGTP diaminopimelate) a (3R,7Z)-3- aspartate--tRNA phosphate -α-D-Kdo- argininosuccinate gluconate bisphosphate fadJ terminal dehydrogenase methyltransferase: methyltransferase: nudF nudC methyltransferase: oxo-acid L-phosphatidate protein for iron- ethidium ethidium multidrug carrier-protein] 6 kdsB dipeptidase: reductase: gpr RNA 2',3'-cyclic glycosylase: triphosphohydrolase: dgt meso-2,6- hydroxytetradec- a [carboxyl-carrier ligase: aspS (2->6)-lipid A synthetase: argG 2,3-bisphosphoglycerate- D- nucleotidase: phosphate phosphatase: yfiC rlmA rlmH transaminase: cytidylyltransferase: sulfur cluster tripeptide anan erythromycin erythromycin efflux pump reductase: fabI protein dimer]-N - an L-aspartyl-asp L,D L,D murein phosphoglycerate cysQ phosphodiesterase: tag YgiZ 7-enoyl-[acp] transpeptidase: ldtD UDP-N- independent gluconate 2-dehydro-3- ddpX cyclase: rtcA aceK 6 1 β 3 ybdL cdsA assembly: iscU diaminopimeloyl- deoxycholate deoxycholate MdtEF-TolC myristoyl-acyl carboxybiotinyl-L-lysine [tRNA ] carboxypeptidase: transpeptidase: ldtD mutase: gpmA an N - 37 an N - 745 thpR D-ribofuranose reduced - an N - 1915 asp acetylenolpyruvoylglucosamine phosphoglycerate kinase: idnK deoxygluconokinase: Phosphorylated enoyl-CoA an [RNA]-3'- sn-glycerol AMP AMP nicotinamide D- 2'-deoxyguanosine triphosphate 7 carrier protein- CMP-Kdo ldtD methyladenineval methylguanine 5-phosphate methylpseudouridine an apurinic site an S-sulfanyl-[cysteine D-alanine) EnvY tRNA D-alanyl- L-arginino-succinate reductase: murB mutase: gpmM kdgK DNA-binding hydratase: D-ala ribunucleoside-2',3'- an isocitrate 3-phosphate an [RNA]-3'- ribonucleotide 3-methyladenine a proteinogenic 4-(methylsulfanyl) a CDP-2,3,4-saturated- YceK an octanoyl-[acp] 3-hydroxy cis ∆ dependent lipid IVA 4-amino-4-deoxy- AMP fadB dehydrogenase in tRNA1 in 23S rRNA ribunucleoside- in 23S rRNA within DNA amino acid diacylglycerol desulfurase]-[disordered-form acyltransferase: D-alanine- a mature peptidoglycan superpathway of D-glucarate D-gluconate transcriptional cyclophosphate -2-oxobutanoate scaffold protein] complex tetrapeptide D-ala iron(III) -tetradecenoyl- adding a nascent peptidoglycan a nascent peptidoglycan with (L-alanyl-γ-D-glutamyl- L-arabinosyltransferase: 2'-phosphate ferrichrome [acp] lpxM arnT UDP-N-acetyl- and D-galactarate degradation 6-phosphate activator BtsR (S)-3-hydroxy-(7Z) hydroxamate ferrichrome enzyme: with L,D cross links (meso- a nascent peptidoglycan with with (L-alanyl-γ-D-glutamyl- meso-2,6-diaminopimeloyl- argininosuccinate α-D-muramate 2-phospho-D-glycerate KDGP YchE ferric coprogen ABC ferric coprogen β-ketodecanoyl- dehydratase: 3-deoxy- murF diaminopimelate containing) γ meso-2,6-diaminopimeloyl- D-alanine) tetrapeptide lyase: argH -tetradecenoyl-CoA transporter [acp] fabZ D-manno- (L-alanyl- -D-glutamyl-meso- synthase: fabB α-D-Kdo-(2->4)-α- 2,6-diaminopimelate) tripeptide glycine) tetrapeptide D-galactarate D-glucarate YghG superpathway of fatty acid biosynthesis I (E. coli) octulosonic α α YgiB D-Kdo-(2->6)-lipid A acid 4'- -L-Ara4N- - enolase: eno murein tyr Kdo-(2->4)-α- UDP-N- 2-keto-3- 1498 + + a (2E,7Z)- Metabolic Regulator transferase: arg acetylmuramate:L- deoxygluconate D-ribulose 7 a DNA containing α 6 37 tetradeca-2,7- tyrosine--tRNA Kdo-(2->6)-[P4'- (2E,9Z)- a uracil a [lipoyl-carrier6 a nucleoside core -D-Kdo-(2->4) di-trans,octa-cis an [RNA]-3'- transpeptidase: Li+ Li + a 3-oxodecanoyl-[acp] ADP-heptose:Kdo2-lipid waaA γ galactarate D-glucarate 6-phosphate Aldehyde Degradation a DNA with a reduced hydroxypyruvate m GTP an organic hydroperoxide α a 5'-hydroxy- N -dimethylallyladenosine a sulfurated NhaA dienoyl-[acp] Biosynthesis ligase: tyrS UDP-N-acetyl- α-L-ara4N]-lipid A alanyl- -D- hexadecenoyl-CoA 5-phosphate CpxR-P in 16S rRNA protein] N -[(R) an apurinic/ triphosphate oligosaccharide- di-trans,octa-cis - -D-Kdo- -undecaprenyl ribunucleoside- YdcF Na Na A heptosyltransferase: acetyl-CoA an L-tyrosyl-Tyr α-D-muramoyl- a mature peptidoglycan glutamyl-meso- dehydratase: dehydratase: aldolase: eda ITP unresolved hydrogenase 3 apyrimidinic site inosine -undecaprenyl (2->6)-lipid A ribonucleotide- GTP in tRNA [sulfur carrier] ldtE phosphoenolpyruvate 7 3 -dihydrolipoyl]- peroxiredoxin: osmC diphosphate waaC [tRNA ] L-alanyl-γ-D- with L,D cross-links (meso- diaminopimelate garD gudD recombinational enoyl-CoA hydroxypyruvate lipid A (E. coli diphosphate 2',3'- 3'-[RNA] 7 Tyr a mature peptidoglycan with a mature peptidoglycan D-ribulose 5- m GTP 16S rRNA m U1498 L-lysine K-12 core type) Kdo2-lipid A cyclophosphate murein ppGpp biosynthesis glutamyl-meso-2,6- diaminopimelate containing) ligase: mpl or Holliday hydratase: hydrogenase: reductase: ghrA 6 inosine nucleoside triphosphate isopentenyl- YbhC 3-oxoacyl-[ACP] cis-∆ - a tRNA α-Kdo-(2->6) (L-alanyl-γ-D-glutamyl-meso- γ superpathway of methylglyoxal degradation phosphate 1- protein pyrophosphatase: methyltransferase: deoxyribonuclease thiol peroxidase: bcp phosphotransferase: RNA AcrZ A diaminopimeloyl- with (L-alanyl- -D-glutamyl- L-ornithine D-glyceraldehyde junctions, fadJ hycD hycC protein N - nucleosidase: pyrophosphohydrolase: undecaprenyl- adenosine tRNA reductase: fabG tetradecenoyl- heptosyl-Kdo2-lipid A -lipid IV 2,6-diaminopimelate) tripeptide meso-2,6-diaminopimeloyl- pyruvate pyruvate L-lactaldehyde ITPase: dehydrogenase: phosphoaspartate yceF rsmE V: nfi lpxT transpeptidase: dequalinium dequalinium acetyl-CoA D-alanyl-D-alanine kinase: pykF 3-phosphate created by RecA hycF hycG yajO hydroxypyruvate (dihydrolipoyl) rihC mazG lipid hydroperoxide pyrophosphate ligase: rtcB methylthiolase: ethidium ethidium [acp]:NAD+ glycine) tetrapeptide phosphoenolpyruvate degradation (aerobic) yjjX hycB hycE phosphatase: cpxA reductase: ghrB 7 3 lysine:NAD+ peroxidase: tpx α-D-Kdo-(2->4) miaB ldtC MdfA oxidoreductase: carboxyltransferase: agmatine ornithine pyrophosphatase: 6 YeiH a drug a drug accA accD pppGpp KDO synthetase: ppsA methylglyoxal DNA enoyl-CoA N - an N - 1498 oxidoreductase: lpd a 2'- lpxT di-trans,octa-cis -α-D-Kdo- a (3R)-3- fabI ADP-heptose--LPS acetyl-CoA:ACP phospho-N- decarboxylase: SAM lys UDP-N-acetyl- pyruvate helicase: 1-deoxy-D- methylguanosine methyluracil hypoxanthine D-ribofuranose a nucleoside 5'- -undecaprenyl GMP a ribonucleic acid 2-methylsulfanyl-N - 37 murein a nascent [+ 2 more] [+ 2 more] transferase: speC α hydratase: an oxidized (R)-glycerate a [lipoyl-carrier6 deoxyribonucleoside an alcohol di-trans,octa-cis (2->6)-lipid A an unsulfurated hydroxydecanoyl-[acp] heptosyltransferase: transacylase: fabH guanosine-5'- waaA acetylmuramoyl- agmatinase: -D-muramoyl- kinase: pykA recG fadB xylulose 5- CpxR 5'-phosphate in 16S rRNA monophosphate lipid A-core 1- phosphate met 5'-deoxyadenosine dimethylallyladenosine YraJ triphosphate,3'-diphosphate speB L-alanyl-γ-D- (S)-lactaldehyde IDP hydrogenase 3 phosphate protein]-N - 5'-monophosphate -undecaprenyl 1-diphosphate [sulfur carrier] in tRNA transpeptidase: peptidoglycan BcsC waaF GTP Trp pentapeptide- lipoyl-L-lysine diphosphate pyrophosphokinase: relA phosphatase: gpp transferase: mraY glutamyl-meso-2,6- sulfoquinovose degradation I a DNA segment (S)-3-hydroxy-(9Z) phosphate ldtB with (L-alanyl- a (7Z)-tetradec- malonyl-CoA a tRNA α-Kdo-(2-> S-adenosylmethionine lysine diaminopimelate 5-dehydro-4- glyoxalase methylglyoxal lactaldehyde (3R)-3- 7-enoyl-[acp] 2 guanosine 3'-diphosphate pyruvate I: gloA methylglyoxal dehydrogenase: -hexadecenoyl-CoA a nucleoside NupG a nucleoside (heptosyl) - tryptophan--tRNA 4)-α-Kdo-(2- decarboxylase: speD decarboxylase: deoxy-D-glucarate reductase reductase: yqhD RbbA murein γ-D-glutamyl- hydroxydecanoyl- 2 5'-triphosphate 3'- gluconeogenesis I Carbohydrate Biosynthesis aldA Kdo -lipid A ligase: trpS >6)-lipid IVA undecaprenyldiphospho- glycogen biosynthesis I (from ADP-D-Glucose) ldcC 6-sulfo-D-quinovose [acyl-carrier malonyl-ACP diphosphatase: spoT an L-tryptophanyl-Trp N-acetylmuramoyl-L- enterobacterial common antigen biosynthesis (NADPH- transpeptidase: meso-2,6- protein] ∆ decarboxylase: [acyl-carrier-protein] S [tRNA ] γ dependent) methylglyoxal (S)-lactate Ag43 3-oxo-cis- 9- an acetyl-[acp] alanyl- -D-glutamyl-meso β putrescine dAdoMet reductase: yeaE 2552 dehydratase: fabZ lipopolysaccharide -malonyltransferase: ADP-L-glycero- -D-manno sulfoquinovose (R)-S- + ldtA diaminopimeloyl- hexadecenoyl- fabB fabD -2,6-diaminopimeloyl- (S)-malate -heptose biosynthesis D-glucopyranose lysine α-dehydro- lactoylglutathione a [protein]-L- (2E,11Z)- queuosine at 2''-O-acetyl- DNA with adenine:7,8- uridine methyl β-D-glucoside DNA combined with (S)-3-hydroxy-(5Z) a [DNA]-3'- a 5'-phospho- [acp] glucosyltransferase: trp D-alanyl-D-alanine isomerase: yihS β-deoxy-D his717 ADP-ribose a nucleoside NAD an acyl-[acyl- an [RNA]-3'- a 5'-hydroxy- an inactive gly waaG lauroyl palmitoleoyl α-D-glucopyranose 1-phosphate 6-phosphate decarboxylase: methylglyoxal methionine octadecenoyl-CoA a 5'-phospho- position 34Asp glu ArcB-P dihydro-8- in 23S rRNA 6-phosphate exogenous DNA to form triphosphate a ribonucleic acid -dodecenoyl-CoA hydroxyl [DNA] a malonyl-[acp] ribonucleoside a reduced glycine) D-glucuronate ExuT D-glucuronate synthase: fabB GTP ppGpp acyltransferase: acyltransferase: cadA autoinducer AI-2 degradation -glucarate L-lactate XTP ATP of a tRNA oxoguanine mismatch a recombinational junction IMP carrier protein] ribonucleoside- ribonucleotide- GTP SAM FtsY D-galacturonate D-galacturonate malate D-sedoheptulose hydroxyacylglutathione (S)-lactaldehyde reductase: dkgA dehydrogenase: [DNA] 3-hydroxyacyl-CoA DNA 3'-phosphate 3'-[RNA] triphosphate flavodoxin tetrapeptide a (2E)-dec-2-enoyl-[acp] lpxL lpxP dehydrogenase, 6-deoxy-6- aldolase: garL hydrolase: gloC enoyl-CoA 2''-O-acetyl- adenine 23S rRNA 2'-O β reductase glucosyl-(heptosyl) a malonyl-[acp] N-acetylglucosaminyl 7-phosphate phosphoglucomutase: sulfo-D-fructose lldD protein- hydratase: glutamyl-Q ADP-ribose methyl -D- inosinate RNA dehydrogenase: fadJ ligase: ligA β-ketoacyl 3'-PO4/5'- a (9Z)-3- 2-Kdo2-lipid A NAD-requiring: dTDP-glucose pgm spermidine methylglyoxal methionine- DNA 5' tRNA(Asp) glycosylase: -ribose U2552 glucoside 6- resolvasome: polymerase: [acyl-carrier ribonucleoside YfgH oxohexadec- transferase: murG maeA D-sedoheptulose cadaverine reductase: dkgB fadJ phosphohistidine deacetylase: mutY methyltransferase: nucleosidase: OH RNA GDP kinase: adk pyrophosphorylase: synthase: fructoselysine AI-2 S-lactoylglutathione lactaldehyde XTPase: S-oxide adenylyl synthetase: ymdB phosphate ruvC ruvB ruvA ppnN rpoA 3-hydroxyacyl-CoA DNA protein] ligase: rtcB triphosphate 9-enoyl-[acp] α 2 rffH 7-phosphate speE yjjX phosphatase: sixA rlmE glucohydrolase: reductase D-ala decanoyl-[acyl- GDP guanosine-3',5'- -Kdo-(2->4)- Kdo - α-D- and psicoselysine 6-deoxy-6- hydrolase: yeiG dehydrogenase: pyruvate reductase: transferase: gluQ rpoC rpoB dehydrogenase: fadB ligase: ligB synthase: fabB carrier-protein] acetoacetyl-[acp] GDP kinase: ndkpyrophosphokinase: relA thr α-Kdo-(2->6)- (palmitoleoyl) lipid II (meso malate isomerase: lpcA sulfofructose pyruvate tartronate semialdehyde methylglyoxal msrB rtcA bglA D-ribofuranose activase: nrdG GfcB 9 bis(diphosphate) 3'- glucopyranose aminopropylcadaverine degradation autoinducer- aldA enoyl-CoA an apurinic site 2552 resolution of recombinational YqeJ reductase: fabI synthase: fabB β threonine--tRNA (lauroyl)-lipid IVA -lipid IVA diaminopimelate dehydrogenase: D-glycero-D- kinase: yihV reductase: gpr glutamyl- adenine a 2'-O- 5-phosphate hypoxanthine GMP a ribonucleic acid an active 3-oxo-cis-∆ - -ketoacyl-ACP diphosphatase: spoT α 1-phosphate synthase: speE 6 2 kinase: lsrK hydroxyacylglutathione hydratase: an adenosine- acetate ADP-D-ribose within DNA methyluridine β junction formation a ribonucleic acid 3-oxo-(5Z)-dodecenoyl-CoA synthase: fabH GDP diphosphokinase: spoT ligase: thrS containing) mdh UDP-N-acetyl- -D-glucosamine dTDP-glucose manno-heptose hydrolase: gloB a protein-L- fadB 5'-diphospho- queuosine at ArcB -D-glucose NMN AMP [DNA] acyl-carrier protein a 3-oxoacyl-[acp] a flavodoxin ribonucleoside hexadecenoyl- glucosyl-(heptosyl)2- acetoacetyl-[acp] an L-threonyl-Thr pyrophosphorylase: N -(D-psicosyl) (4S)-4-hydroxy-5- tartronate XDP in 23S rRNA of two intact strands met 5'-deoxyadenosine [acp] 7-phosphate glucose-1-phosphate -L-lysine 6-deoxy-6-sulfo-D- (S)-lactate methionine- 5'-[DNA] position 34Asp MeOH 6-phosphate semiquinone triphosphate YpjB Kdo2-lipid A-phosphate synthase: fabF [tRNA ] myristoyl-acyl rfbA phosphooxypentane- semialdehyde (S)-3-hydroxy-(11Z) of a tRNA reductase a decanoyl-[acp] reductase: fabG Thr myristoyl-acyl fructose 1-phosphate 2,3-dione (R)-S-oxide a ribonucleoside a ribonucleoside a tRNA carrier protein- malate UDP-N- adenylyltransferase: spermidine aminopropylcadaverine fructoselysine 3- reductase: garR (R)-lactate acetol -octadecenoyl-CoA a β-lactam carrier protein- dehydrogenase, acetylglucosamine heptose 7- epimerase: frlC Pbl DgcJ lipopolysaccharide core GDP dependent dependent dTDP-α-D-glucose phosphate glgC L-lactate DedA β IMP 3'-phosphate 5'-monophosphate dAMP a (3R,9Z)-3- acyltransferase: acyltransferase: NAD-requiring: 2-epimerase: wecB kinase: rfaE 6 (4S)-4-hydroxy-5- dehydrogenase: -lactamase: β-ketododecanoyl- heptosyltransferase: an acetoacetyl-[acp] N -(D-fructosyl) (R)-glycerate L-lactaldehyde IMP phosphatase: nucleoside 3'- nucleoside 5'- dAMP phosphatase: phoA hydroxyhexadec- waaQ lpxM lpxM maeA 6-deoxy-6- phosphonooxypentane- D-lactate lldD L-1,2-propanediol dacD [acp] 9-enoyl-[acp] α dTDP-glucose 4,6- α α -L-lysine 2,3-dione isomerase: lsrG dehydrogenase: dld dehydrogenase: degradation monophosphate monophosphate BorD synthase: fabB di-trans,octa-cis- UDP-N-acetyl- -D-mannosamine dehydratase: rffG D-glycero-β-D- a 1,4- -D-glucan ADP- -D-glucose sulfofructose- (anaerobic) (2E,7Z)- 1-palmitoyl- α GMP-N-ε-(N-α-acetyl 1-palmitoyl- α-Kdo-(2-> phoA dAMP cyclopropane undecaprenyl phosphate gldA asp a [protein]- - an mRNA oxidized a ribonucleic acid long chain ADP-L-glycero-β- glycerophosphoglycerol penicillinase: 3 α UDP-N-acetyl-α-D-glucosamine manno-heptose 1-phosphate glycerate 2- hexadecenoyl-CoA Ap4A sn-glycerol L-glutamate thr a protein lysine methyl ester) sn-glycerol a palmitoyl-[acp] 4)-α-Kdo-(2- a 2'-deoxyribonucleoside 5'-triphosphate [DNA] phosphatase: aphA phosphatase: aphA 9 glucosyl-(heptosyl) - fatty acid (CFA) -D-Kdo-(2->4) (Kdo)2-lipid 3-hydroxy-5- GMP adenine CheY-P flavorubredoxin polyphosphate D-manno-heptose nucleoside 5'- phosphohydrolase: yfbR 2 α 1,7-bisphosphate aldolase: yihT kinase: glxK 3-phosphate 5'-phosphoramidate >6)-lipid IVA dacA 3-hydroxy cis ∆ Kdo -lipid A-phosphate biosynthesis ser - -D-Kdo- dTDP-4-dehydro-6- glycogen fructoselysine phosphooxypentane- endoribonuclease: 3-phosphate 3'-nucleotidase: 5'-ribonucleotidase: YgaY a 3-oxododecanoyl-[acp] L-serine:tRNASer (2->6)-lipid A A, cold adapted UDP-N-acetyl-D- α synthase: 6-kinase: frlD (S)-propane- (S)-lactaldehyde enoyl-CoA phosphate- glycerophosphoryl diester DNA polymerase: polA CadC monophosphate 5'-deoxyribonucleotidase: -hexadecenoyl- ligase (AMP- mannosamine deoxy- -D-glucopyranose 2,4-dione chemotaxis protein threonine ghoS purine nucleoside ADP-heptose:Kdo2 phosphodiesterase: glpQ β-lactamase: [acp] malate UDP-N-acetylglucosamine--undecaprenyl- glgA glycerate 2- 1,2-diol hydratase: diadenosine acyl-CoA:1-acyl- ATP-dependent zinc phosphoramidase: dependent acyl-[acp]:1-acyl- cpdB ushA lipopolysaccharide a [phospholipid] forming): serS phosphate N- dehydrogenase: 6 L-1,2-propanediol GMP fadJ tetraphosphatase: protein methyltransferase: dehydratase: tdcB NADH:flavorubredoxin exopolyphosphatase: ppx -lipid IVA- DNA polymerase: phosphatase: aphA ushA dehydratase: olefinic fatty acid dehydrogenase: D-glycero- N -(6-phospho- kinase: garK adenine sn-glycerol-3- phosphoaspartate cheR metalloendoprotease: RNase: rnlA hinT exonuclease: sn-glycerol-3- ampC YqhH core heptose a 3-oxoacyl-[acp] an L-seryl-ser oxaloacetate acetylglucosaminephosphotransferase: rfe wecC dTDP-4-dehydro- β-D-manno- L-galactonate oxidoreductase: reductase: deaminase: apaH phosphate 2-O- hflC hflK ftsH reductase: norW rph phosphate 2-O- heptosyltransferase: glycerophosphoglycerol umuC umuD a substituted a ribonucleoside a ribonucleoside 3-oxoacyl-[ACP] fabZ (II) kinase: waaY [tRNA ] maeB 6-deoxy-D-glucose α D-fructosyl) 3-sulfolactaldehyde DHAP 3-hydroxy-2,4- fucO phosphatase: cheZ threonine waaC inosine 2'-deoxyribonucleoside cyclopropane ser heptose-1,7- a 1,4- -D-glucan pentadione degradation guaC adeD acyltransferase: acyltransferase: phosphodiesterase: ugpQ reductase: fabG transaminase: wecE -L-lysine 2-phospho-D-glycerate enoyl-CoA a [protein]-L-5 deaminase: ilvA mRNA N-α-acetyl lysine DNA polymerase: polB β-amino acid 5'-monophosphate fatty acyl a tRNA phosphoenol α bisphosphate 7- trehalose biosynthesis I 5-phosphate (S)-propane- plsC glutamate-O interferase: mqsR GMP a nucleoside long chain plsC YidI pyruvate lipid I UDP-N-acetyl- -D- phosphatase: pyruvate 1,2-diol hydratase: a peptide NorV methyl ester a ribonucleic acid sn-glycerol 3-phosphate glycerol YtfB a (2E,9Z)- glucosyl-(heptosyl) phospholipid pyruvate mannosaminuronate fructoselysine 3-sulfolactaldehyde thiolase: lsrF aldehydo-L- fadB ADP 1-palmitoyl- CheY -methyl-ester 2-oxobutanoate diphosphate polyphosphate ADP heptosyl- DNA polymerase: dnaE phosphatase: aphA hexadeca-2,9- 3-Kdo2-lipid A- synthase: cfa carboxykinase dTDP-4-amino-4,6- gmhB α IMP hypoxanthine an mRNA fragment dipalmitoyl Kdo2-lipid IVA a (3R)-3- phosphoenolpyruvate 1,4- - 6-phosphate reductase: yihU galactonate 2-myristoyl acyl-carrier protein DNA polymerase: dinB dienoyl-[acp] bisphosphate (ATP): pck dideoxy-α-D-galactose glucan D-glucopyranose deglycase: frlB (S)-3-hydroxy-(7Z) phosphatidate 2'-deoxyadenosine hydroxydodecanoyl-[acp] a [phospholipid] synthetase: ppsA UDP-α-D-glucose DHAP L-galactonate phosphatidate cyclopropane UDP-N-acetyl-D- β branching 6-phosphate oxidoreductase: -hexadecenoyl-CoA [DNA] ferric lipopolysaccharide 1,6- D-glycero- -D- enzyme: 3-sulfopropanediol enterobactin palmitoleoyl- fatty acid mannosaminuronic dTDP-4-amino-4,6- manno-heptose trehalose-6- β lgoD ferricferric FxsA (3R)-3- [acp]:NAD+ galactosyltransferase: acid transferase: rffM glgB -D-glucose outer waaB dideoxy-D-galactose 1-phosphate phosphate 6-phosphate lys membrane enterobactinenterobactin hydroxydodecanoyl- oxidoreductase: pro acyltransferase: rffC synthase: otsA D-tagaturonate complexcomplex [acyl-carrier protein] fabI β 3-oxoacyl-[ACP] proline--tRNA α 34 2498 6 transport D-myo-inositol α ε -ketoacyl-ACP α,α-trehalose GDP- -D- 1-palmitoyl- an N-terminal L- an N -L- 37 N ,N -diacetyl-lysyl- dehydratase: fabZ galactosyl-glucosyl- reductase: fabG ligase: proS phosphoenolpyruvate heptose 1-phosphate a glycogen activated ferric enterobactin asp59 RNase II a cytidine a cytidine a [protein] (L-serine/L- 1-palmitoyl- F6P D-cellobiose 6'-phosphate complex 3'-cmp synthase: fabF an L-prolyl-Pro dTDP-4-acetamido-4,6- 6-phosphate mannose sn-glycerol degradation alanyl-[S18 protein a purine threonylcarbamoyladenine a protein a protein (2,3,4,5) (heptosyl)3-Kdo2- lipid II adenyltransferase: a protein pyruvate- complex NarL-P in tRNA in 23S rRNA dGTP ser threonine) phosphate sn-glycerol a myristoyl-[acp] D-alanyl-D-alanine YceI β [tRNA ] dideoxy-α-D-galactose formate lyase 3-phosphate substrate mRNA of 30S ribosome] ribonucleoside 3-phosphate in tRNA 3'CMP D-alanyl-D-alanine lipid A-bisphosphate -ketoacyl-ACP Pro rfaE β serine β-barrel assembly- tetrakisphosphateD-myo-inositol a palmitoleoyl-[acp] GDP- tRNA (cytidine- 23S rRNA 2'-O serine deaminase: tdcG protein-serine/threonine fructose-6- 6-phospho- -D-glucosyl- YicG a (2E)-dodec-2-enoyl-[acp] synthase: fabB a tRNA trehalose-6- ATP- pyruvate ferric acyl-CoA:1-acyl- ribosomal-protein- purine nucleoside acyl-[acp]:1-acyl- phosphate tRNA (1,4)-D-glucose DinF phosphatase: phoA carboxypeptidase: enolase: eno ADP-D-glycero-β- mannose enterobactin protein exoribonuclease: 2'-O)-ribose -ribose C2498 S18-alanine N- phosphatase: pphB endoprotease: enhancing (2,3,4,5) phosphate glycogen degradation I Carbohydrate Degradation dependent formate- mannosyl sn-glycerol-3- methyltransferase: methyltransferase: nucleoside triphosphate L-serine deaminase: sdaA phosphorylase: sn-glycerol-3- aldolase: fsaB threonylcarbamoyladenosine glucohydrolase: chbF cytidine 3' UDP-D- a 2,3,4-saturated a (3R)-3-hydroxyacyl- 4-acetamido-4,6- D-manno-heptose phosphatase: L-rhamnose degradation I D-arabinose degradation I esterase: fes phosphate 2-O- phosphoaspartate rnb pyrophosphohydrolase: acetyltransferase: deoD degQ protease: bepA tetrakisphosphate dacD glucose:(glucosyl) dideoxy-D-galactose L-lyxose fucose degradation D-allose HslVU lyase hydrolase: phosphatase: narX trmL rlmM serine deaminase: tdcB protein-serine/threonine phosphate 2-O- dehydratase: tcdA fatty acyl-[acp] [acyl-carrier protein] otsB protease: deactivase: acyltransferase: mazG rimI acyltransferase: 6 nucleotidase: cpdB D-alanyl-D-alanine dodecanoyl-[acyl- LPS α-1,3- 2-phospho-D-glycerate transferase: rffT degradation degradation gmm α-D-ribose- phosphatase: pphA fructose-6- 6-phospho-β-D-glucosyl- serine periplasmic serine phosphohydrolase: (3R)-3- ADP-L-glycero-D- hslU hslV adhE N-(2,3- plsC a 2'-O- 34 2498 L-serine deaminase: sdaB plsC a cyclic N -L- carrier-protein] 3-oxo-cis- glucosyltransferase: a glycogen dihydroxybenzoyl) a nucleoside 5'- a 2-O- an N-terminal N-acetyl- 1-phosphate a purine base phosphate (1-4)-D-glucose nucleoside 3'- carboxypeptidase: reductase: fabI hydroxyacyl-[acyl- mannoheptose 6- α-L-rhamnopyranose D-arabinopyranose β NarL methylcytidine methylcytidine L-alanyl-[S18 protein a [protein] Ser/Thr threonylcarbamoyladenosine endoprotease: endoprotease D-myo- appA YbdJ vaccenoyl- waaO carrier protein] α α -L-fucopyranose -L-serine trimer 1-palmitoyl-2- monophosphate pyruvate 1-palmitoyl- aldolase: fsaA glucohydrolase: bglB TrkA [acp] epimerase: rfaD , -trehalose β-L-lyxopyranose D-allopyranose in tRNA in 23S rRNA dGMP of 30S ribosome] 37 in tRNA degS DegP: degP monophosphate inositol (2,4,5) dacC dehydratase: fabZ phe 2,3-bisphosphoglycerate- L-rhamnose a peptide PflB ferric complex cis-vaccenoyl acyl-carrier protein 2-myristoyl palmitoleate synthase: independent lipid III glycogen L-fucose GDP D-mannose phosphatidate phosphatidate D-glyceraldehyde phosphatase: aphA D-alanyl-D-alanine a dodecanoyl-[acp] fabF galactosyl-(glucosyl) phenylalanine--tRNA ADP-L-glycero-β- phosphorylase: L-lyxose mutarotase: D-arabinose mutarotase: D-allose 3-phosphate dihydroxyacetone 6-phospho-β-D-glucosyl- a peptide a peptide trisphosphate 2-(heptosyl)3-Kdo2- 2,3,4-saturated phosphoglycerate ligase: pheS pheT D-manno-heptose glgP isomerase: rhaM isomerase: fucI fucU kinase: (1,4)-D-glucose cytidine carboxypeptidase: lipid A-bisphosphate fatty acyl- 3-hydroxyacyl- an L-phenylalanyl-Phe mutase: gpmM alsK [acp]:NAD+ [tRNA ] rhaA β glucohydrolase: ascB [acp] a (3R)-3- Phe colanic acid building blocks biosynthesis lipid III flippase: wzxE -L-rhamnopyranose α-L-fucopyranose dacA EssQ β-ketomeristoyl- oxidoreductase: α D-ribulose aldehydo-D-allose YqjD α ε lipopolysaccharide dehydratase:hydroxydecanoyl-[acp] fabA a tRNA an -limit dextrin L-xylulose 6-phosphate N ,N -diacetyl- [acp] an (11Z)-3- glucosyltransferase: fabI 3-phospho-D-glycerate D-glucopyranose D-glucopyranose 6-phosphate D-ala synthase: fabB oxooctadec- waaJ D-glucopyranose L-rhamnose L-fucose lysyl-D-alanine 11-enoyl-[acp] 3-hydroxydecanoyl- 6-phosphate lipid III galactose degradation I (Leloir pathway) L-xylulose isomerase: D-ribulokinase: isomerase: fucI rhaA fucK allose-6- galactosyl-(glucosyl) [acp] phosphoglycerate limit dextrin α-1,6- kinase: phosphate a 3-oxotetradecanoyl-[acp] 1402 6 3 3 2 dehydrase: fabA kinase: pgk β glucohydrolase: lyxK YhdV 3-oxo-cis- -(heptosyl) -Kdo - -D- L-fuculose isomerase: GDP-α-D- an N -L- 37 WbbK glgX a trans-2- D-xylonate 1-palmitoyl- a cytidine (S)-3-hydroxy-(11Z) an N-terminal L- N-(4-aminobenzoyl) 1-myristoyl- D-myo-inositol vaccenoyl- lipid A-bisphosphate phosphoglucomutase: galactopyranose keto-L-rhamnulose D-ribulose 1-phosphate rpiB HMP-PP enoyl-[acyl- mannose sn-glycerol a 5'-phospho- cyclic-AMP 3-sulfino-L-alanine in 16S rRNA -octadecenoyl-CoA alanyl-[S5 protein -L-glutamate threonylcarbamoyladenine an mRNA a myristoyl-[acp] sn-glycerol a peptidoglycan dimer L-histidinol 4-nitrophenyl ω a trans-2-enoyl- glucose-6- L-xylulose ATP ribonucleoside- 2 ATP with pentapeptide (1,2,3,4,5)- a [protein]-L-proline ( = 180) [acp] met pgm carrier protein] 3-phosphate of 30S ribosome] in tRNA 3-phosphate H O AMP IaaA 3-oxoacyl-[ACP] reductase: [acyl-carrier protein] (3R)-3- methionine--tRNA 13-DPG phosphate 5-phosphate L-fuculokinase: D-xylonate [RNA] RNase: relE stems (meso- phosphate phosphate Lipid A-core isomerase: galactose-1- α-D- HMP-PP GDP- cAMP cysteine sulfinate 16S rRNA 2'-O 3-hydroxyacyl-CoA p-aminobenzoyl- 6 6 pentakisphosphateD-myo-inositol peptidyl-prolyl cis- reductase: fabG fabG hydroxydecanoyl- ligase: metG epimerase: glucopyranose fucK D-allulose 6- hydrolase: enoyl-[acyl- dehydratase: mannose dehydrogenase: ribosomal-protein- tRNA m t A37 RNase: yafQ acyl-[acp]:1-acyl- ATP pyrophosphatase: diaminopimelate L-histidinol- nitrophenyl AMP heptosyl [acyl-carrier an L-methionyl- pgi maltotetraose a debranched phosphate acyl-CoA:1-acyl- RNA 5' phosphodiesterase: desulfinase: sufS -ribose C1402 S5-alanine N- glutamate containing) trans isomerase: surA Met α galM α-limit dextrin cof carrier- yagF hydrolase: sn-glycerol-3- fadJ methyltransferase: ycaO (2,3,4,5) FetB transferase: [elongator -D- 1-phosphate L-xylulose 5- D-ribulose- adenylyl cpdA methyltransferase: acetyltransferase: hydrolase: mRNA interferase: higB sn-glycerol-3- Aer phosphate phosphatase: phosphatase: phoA protein] tRNA ] glucopyranose glucose and glucose-1-phosphate degradation phosphate protein] nudK phosphate 2-O- cysteine sulfinate rsmI abgB abgA trmO phosphate 2-O- peptidyl-prolyl cis- a (3R)-3- a (3R,11Z)-3- waaU dehydratase: fabZ elongatorMet glyceraldehyde- phosphate 3- L-fuculose 1-phosphate transferase: rimJ phosphatase: ushA pentakisphosphate 1-phosphate α aldolase: fucA reductase: acyltransferase: desulfinase: csdA 6 acyltransferase: nucleoside triphosphate 5'-ribonucleotidase: hydroxytetradecanoyl-[acp] hydroxyoctadec- tRNA triose- 3-phosphate -D- maltodextrin epimerase: L-rhamnulofuranose D-allulose-6- HMP-PP D-xylonate plsC rtcA 3-hydroxyacyl-CoA an N -methyl- ribosome-dependent γ a peptidoglycan dimer trans isomerase: fkpA dehydrogenase: galactopyranose phosphorylase: sgbU phosphate 3- fabI dehydratase: a 2'-O- 1402 an N-terminal N-acetyl- mRNA interferase: yafO plsC pyrophosphohydrolase: L-alanyl- -D- phoA 4-nitrophenyl ushA phosphohydrolase: 11-enoyl-[acp] core oligosaccharide- phosphate F6P UTP--glucose- maltodextrin hydrolase: α a 5'-(5'- AMP methylcytidine dehydrogenase: L-alanyl-[S5 protein glu 4-aminobenzoate threonylcarbamoyladenosine glutamyl-meso-2,6- with pentapeptide stem lipid A (E. coli K-12 gapA phosphorylase: malP α L-fuculose- epimerase: nudJ yjhG -D-mannose GMP diphosphoadenosine)- sulfite ala fadB mazG (meso-diaminopimelate peptidyl-prolyl cis- isomerase: UTP--glucose- 1-phosphate rhamnulokinase: -D-glucopyranose 1-phosphate alsE 1-phosphate 1-palmitoyl-2- in 16S rRNA of 30S ribosome] 37 in tRNA 1,2-dimyristoyl- diaminopimeloyl- histidinol- phosphate nucleoside 5'- D-myo-inositolappA core type) (no GlcNAc) a (2E)-dec-2-enoyl-[acp] tpiA malP phosphate an acyl-[acyl- (ribonucleoside)-[RNA] an mRNA fragment + D-alanyl-D-alanine containing) (3R)-3- 1-phosphate galactokinase: uridylyltransferase: L-ribulose 5- rhaB DHAP glycolaldehyde 2-dehydro- palmitoleoyl- acyl-carrier protein sn-glycerol AMP trans isomerase: fklB YqjF hydroxymyristoyl- 3-hydroxy cis galK galU aldolase: fucA HMP-P carrier protein] 3-oxo-(11Z)- 3-phosphate diphosphate H GlvB phosphatase: phosphatase: monophosphate (2,3,4,5) vaccenoyl- DHAP D-glyceraldehyde mannose-6- uridylyltransferase: phosphate 3-deoxy-D- sn-glycerol octadecenoyl-CoA peptidyl-prolyl cis- [acyl-carrier 3-phosphate phosphate galU 3-phosphate hisB phoA phosphatase: aphA tetrakisphosphate protein] [acp] trans-2- lysine--tRNA O-antigen building blocks biosynthesis (E. coli) L-rhamnulose α glycolaldehyde F6P arabinonate dehydratase: ligase: lysS isomerase: 1-phosphate -D-glucose- phosphoglucomutase: DHAP adenosine trans isomerase: slyD dehydratase: fabZ decenoyl-ACP Lys manA α-D-galactose α L-ribulose-5- 1-phosphate dehydrogenase: (S)-lactaldehyde histidinol 4-nitrophenol fabZ isomerase: fabA a tRNA α 1-phosphate UDP- -D-glucose phosphate 4- phosphatase: yihX pgm aldA peptidyl-prolyl cis- lysine--tRNA UDP- -D-glucose UDP-α-D- α-D- D-glucopyranose core oligosaccharide- epimerase: 1518 YijD galactose glucopyranose 6-phosphate rhamnulose- YohP trans isomerase: ppiA lipid A (E. coli ligase: lysU D-mannopyranose sgbE 1-phosphate an insertion a [protein chain 1-myristoyl- 1-myristoyl- (2R,3S)-3- 1-chloro-2,4- + adenine1519 / dUMP 1-cis-vaccenoyl- a (2E)-tetradec-2-enoyl-[acp] a (2E,11Z)- K-12 core type) an L-lysyl-Lys 1-phosphate α-D- maltotriose sugar- glyoxylate wound RNA 1-cis-vaccenoyl-sn- glutathione an adenine in DNA a reduced (R)-lactaldehyde arbutin-6-phosphate octadeca-2,11- a (3Z)-dec-3-enoyl-[acp] [tRNA ] 6-phosphate UDP- glucose-6- glucopyranose aldolase: rhaD glycolate sequence elongation factor34 sn-glycerol sn-glycerol isopropylmalate glycerol-3-phosphate RplL dinitrobenzene NADP adenine in 16S rRNA a palmitoleoyl-[acp] sn-glycerol- a [protein]-L-proline (ω = 0) fructose- galactopyranose phosphatase: ybiV element IS30 EF-P]-L-lysine 3-phosphate 3-phosphate flavodoxin dUMP dienoyl-[acp] UDP- UDP-glucose 6- dTDP-glucose phosphate 1-phosphate D-glucopyranose 6-phosphate 2-O-α-mannosyl-D- 6 aldehyde reductase: yqhD 3-phosphate arbutin-6-phosphate 5 lys bisphosphate dehydrogenase: mutase: glf glyoxylate RNA transposase: 3-isopropylmalate glutathione S- DNA adenine 16S rRNA6 m 2 phosphohydrolase: yfbR phosphomannomutase: glucose 4- pyrophosphorylase: isomerase: maltodextrin L-ribulose-5- sugar glycerate degradation acyl-CoA:1-acyl- ribosomal-protein- flavodoxin-+ glucohydrolase: ascB myristoyl-[acyl- β-keto-cis-∆ - aldolase: fbaB cpsG epimerase: ugd rffH pgi phosphate 4- (S)-lactaldehyde DHAP reductase: helicase: insI-3 EF-P-Lys34 acyl-CoA:1-acyl- acyl-CoA:1-acyl- dehydrogenase transferase: methyltransferase: A1518,m 2A1519 (R)-lactaldehyde acyl-[acp]:1-acyl- carrier-protein] UDP-Galf glucosidase: phosphatase: yidA L-arabinose ghrB rhlB hydroxylase: sn-glycerol-3- sn-glycerol-3- sn-glycerol-3- L12-serine yfcF yhdJ NADP 5'-deoxynucleotidase: yfdR reductase: yahK sn-glycerol-3- NlpA cis-vaccen- dodecenoyl-[acp] galE malZ epimerase: (decarboxylating) phosphate 2-O- acetyltransferase: reductase: dimethyltransferase: arbutin 6-phosphate YohK reductase: fabI 2-enoyl- synthase: fabB degradation I 2-O-(6-phospho- transposase: epmC phosphate 2-O- phosphate 2-O- : dmlA rsmA phosphate 2-O- fructose α-D-mannose F6P araD phosphosugar glucokinase: glk α acyltransferase: acyltransferase: acyltransferase: rimL fpr acyltransferase: glucohydrolase: bglA superoxide L-threonine 3- [acp] UDP-α-D- dTDP-glucose phosphoglucomutase: -D-mannosyl) insI-2 6 1518 2'-deoxyribonucleoside aldehyde reductase: ahr 3'-AMP 2'-deoxyguanosine YcaL bisphosphate 1-phosphate phosphatase: yigL glyoxylate RNA plsC plsC plsC glutathione S DNA adenine 6 1519 + plsC dGMP reductase: glucuronate pyrophosphorylase: pgm maltose -D-glycerate a [protein chain + N -dimethyladenine 5'-monophosphate superoxide O-phosphate non-specific ion/solute LamB non-specific ion/solute a myristoyl-[acp] a (5Z)-3-oxododec- aldolase: fbaA UDP-α-D- rfbA α D-xylulose L-arabinopyranose reductase: helicase: elongation factor 50S ribosomal -transferase: methyltransferase: an oxidized /N -dimethyladenine phosphatase: aphA NADP -dependent arbutin 6-phosphate 3'AMP 3'-monophosphate maltose maltose fabI UDP-glucose: - ghrA dbpA transposase: 1,2-dimyristoyl- 3-isopropylmalate 1-cis-vaccenoyl- subunit protein L7 gstA dam H NADPH flavodoxin dismutase: L-threonine O- dGMP phosphatase: phoA 5-enoyl-[acp] his galactose α L-glutamine--D- UDP- 5-phosphate 2-O-(6- EF-P]-5-hydroxy-34 1-myristoyl-2- dehydrogenase: in 16S rRNA aldehyde reductase: ybbO 1-cis-vaccenoyl- glucohydrolase: bglB histidine mannose-1-phosphate dTDP- -D-glucose D-galactose- glucose 4- L-arabinose insI-1 sn-glycerol 2-palmitoleoyl-sn- 6 phosphatase: phoA histidine--tRNA guanylyltransferase: fructose-6- 1-phosphate amylomaltase: phospho-α- L-lysine palmitoleoyl- leuB 2,4-dinitrophenyl- an N -methyladenine 2'-deoxyuridine 2-palmitoleoyl- sodC 3-phosphate 2'-deoxyguanosine deoxyribonucleoside his ABC his 5 epimerase: D-glucopyranose isomerase: glycolate an unwound RNA an insertion sn-glycerol 3-phosphate glycerol-3-phosphate (R)-propane-1,2-diol acyl-carrier protein β HsrA adenosine 3' transporter β-ketopalmityl- a cis- ∆ ligase: hisS cpsB phosphate uridylyltransferase: malQ trehalose degradation II (cytosolic) mannosyl)- S-glutathione in DNA sn-glycerol- hydroquinone -D-glucose 6-phosphate phosphatase: 3'-monophosphate 3-oxo-cis- - His galE araA sequence IS30 3-phosphate 4-methyl-2- superoxide 5'-monophosphate [acp] vaccenoyl-[acp] an L-histidyl- dTDP- aminotransferase: galT D-glycerate 3-phosphate nucleotidase: cpdB dodecenoyl-[acp] [tRNA ] glucose 4,6- glmS ribose hydrolase: with integrated oxopentanoate aphA phosphatase: aphA synthase: fabB reductase: fabG His GDP-α-D- phosphorylation glucose L-ribulose transposon dismutase: phosphatase: yfbR a tRNA β-D-fructose 1,6- dehydratase: D-glucopyranose dehydrogenase: gcd mngB nucleoside 3'- bisphosphate mannose rfbB α,α-trehalose sodB L-threonine O- 5'-deoxyribonucleotidase: D-glucosamine monophosphate 2'-deoxyguanosine PppA a 3-oxohexadecanoyl-[acp] a (3R,5Z)-3-hydroxydodec- glucokinase: β-D-ribopyranose ribulokinase: (R)-glycerate YgiS superoxide 3-phosphate ushA 5-enoyl-[acp] GDP- PRPP biosynthesis 6-phosphate glk D-glucono-1,5-lactone araB phosphatase: aphA fructose-1,6- dTDP-4-dehydro- dismutase: phosphatase: 2'-deoxyribonucleoside mannose 4,6- D-ribose trehalase: treF a mismatched a supercoiled an unstable D-gluconate a [protein] β-aspartyl DNA containing 3-oxo-(5Z)- 1-myristoyl- L-alanyl-γ-D- 5 bisphosphatase: 6-deoxy-α-D- an aminopeptidase pyruvate (S)-lactaldehyde a 2,3,4-saturated 2- a 2,3,4-saturated cis-vaccenate yggF dehydratase: phosphoglucosamine pyranase: L-ribulose 5- glycerate GDP DNA base pair duplex DNA RecA filament- C-terminal glu dipeptide a recognition site DL-allothreonine tetradecenoyl-CoA substrate a palmitoleoyl-[acp] sn-glycerol UDP-N-acetyl- glutamyl-meso-2,6- sodA phoA adenosine 5'-monophosphate 3-oxoacyl-[ACP] 3-hydroxy cis ∆ - gmd D-ribose 5- glucopyranose mutase: glmM rbsD DNA complex L-glutamate dATP 3-phosphate lysophosphatidate fatty acyl-[acp] α hydrogen reductase: fabG dodecenoyl-[acp] gluconolactonase phosphate 2-kinase: D-gluconate 5- aldehyde reductase: yqhD -D-muramate diaminopimeloyl- thr gly glycine--tRNA phosphate β α glxK Rep ribosomal isoaspartyl acetyl-CoA C- aminopeptidase: pyruvate- D-alanine peroxide phosphatase: aphA HtpX dehydratase: fabZ ligase: fructose 1,6- β-D-ribofuranose -D-glucopyranose -D-glucopyranose methyl- helicase: RecA filament- dehydrogenase: e14 prophage; allothreonine pyrophosphohydrolase: acyltransferase: mtfA flavodoxin acyl-[acp]:1-acyl- (S)-lactaldehyde acyl-[acp]:1-acyl- YdjE GDP-4-dehydro- ribose-phosphate dTDP-4- α-D-glucosamine α-D- nucleoside directed kduD protein S6 dipeptide 5-methylcytosine- acetaldehyde- nudB UDP-N-acetylmuramate:L- 2'-deoxyguanosine glyS glyQ bisphosphatase: diphosphokinase: prs dehydrorhamnose UDP-α-D- D-glucopyranose L-ribulose-5- rep DNA complex hydrolase: fadI oxidoreductase: sn-glycerol-3- reductase: yahK sn-glycerol-3- alanyl-γ-D-glutamyl-meso a (3R)-3- Gly α-D-rhamnose 1-phosphate glucopyranose 6-phosphate D-gluconate di- and mismatch stabilisation: modification: specific lyase (glycine- phosphate 2-O- phosphate 2-O- hydroxyhexadecanoyl-[acp] a (3E,5Z)-dodeca- ybhA 3,5-epimerase: rfbC 1-phosphate galactose D-mannose phosphate 4- glycerate triphosphate rimK iaaA aminopeptidase: ydbK -diaminoheptanedioate- a glycyl-[tRNA ] PRPP D-xylose epimerase: 2-kinase: repair: recF restriction forming): glyA ypdF acyltransferase: aldehyde reductase: ahr acyltransferase: 3,5-dienoyl-[acp] Gly degradation hydrolase: nucleoside triphosphate D-alanine ligase: mpl degradation I araD mutL recR recO 5-keto-D- enzyme 3-ketoacyl- plsC + a tRNA GDP-L- dTDP-4-dehydro- garK nudJ 3' to 5' ATP- a [protein] C- pyrophosphohydrolase: CoA a reduced plsC UDP-N-acetylmuramoyl- fructose-1,6- glucosamine- chitobiose degradation mutS mutH gluconate 5- McrA: mcrA a proteinogenic CO2 acetyl-CoA NADP -dependent 5 fucose β dependent terminal α-L- isoaspartyl gly acetaldehyde mazG a peptide γ YtcA (3R)-3- bisphosphatase: -L-rhamnose 1-phosphate D-mannopyranose a stabilized reductase: thiolase: fadA amino acid flavodoxin 1-myristoyl-2- aldehyde reductase: ybbO a 2,3,4-saturated L-alanyl- -D- YidX a protein a protein β cis-∆ -dodecenoyl- synthase: D-ribofuranose D-xylulose 2-phospho- DNA RecA filament- glutamate-α- dipeptidase: glutamyl-meso-2,6- -D-fructose 1,6- peptidoglycan D- hydroxypalmitoyl- glpX fcl acetyltransferase: 6-phosphate D-glucopyranose D-xylopyranose GMP a properly helicase: idnO iadA palmitoleoyl- 1,2-diacyl-sn [acyl-carrier [acp]:NAD+ dTDP-4- glmU 5-phosphate D-glycerate DNA complex L-glutamate DNA cleaved at dAMP acetyl-CoA (3Z)-dodec- acyl-carrier protein (S)-propane-1,2-diol acyl-carrier protein diaminopimeloyl- with incorrect with reduced bisphosphate 2'-deoxyadenosine alanyl-DAP crosslink YbaE oxidoreductase: mannose-6- N,N'-diacetylchitobiose trehalose degradation I (low osmolarity) matched recB recognition site 3-enoyl-CoA sn-glycerol -glycerol 3- D-alanine fructose-1,6- protein] fabI dehydrorhamnose 6'-phosphate ribokinase: xylose DNA base pair 5-dehydro- 3-phosphate phosphate disulfide bondsperiplasmic sulfide groupsprotein disulfide 3'-monophosphate peptidoglycan DD- dehydratase: fabZ fructose-1,6- reductase: rfbD phosphate isomerase: a proteinogenic asp biphosphate bisphosphatase: fbp GDP-4-dehydro- N-acetyl-α-D- isomerase: chitin rbsK glucokinase: a single D-gluconate amino acid endopeptidase: 6-deoxy-β- glucosamine glk xylA protein oxidoreductase: YniD β manA disaccharide stranded DNA YaaU phosphatase: 2'-deoxyadenosine met L-galactose dTDP- -L- 1-phosphate D-ribofuranose α,α-trehalose 6-phosphate D-xylulose disulfide dnaJ mepS a (5Z)-dodec-5-enoyl-[acp] methionine--tRNA F6P rhamnose deacetylase: chbG D-glucopyranose phoA 3'-monophosphate a (2E)-hexadec-2-enoyl-[acp] F6P N-monoacetylchitobiose 5-phosphate lactose degradation III protein disulfide peptidoglycan ligase: metG 6-phosphate trehalose degradation isomerase: phosphatase: aphA an L-methionyl-Met GDP-L- N-acetylglucosamine- 6'-phosphate xylulokinase: VI (periplasmic) fructose-1,6- DD- [initiator tRNA ] glucose-6- fucose L-methionine- 1-cis-vaccenoyl- dsbG oxidoreductase: Met 1-phosphate trehalose-6-phosphate xylB a [protein]- L-methionine- a ribonucleoside a non-methylated a 7,8-dihydro-8- 1-palmitoyl- a [chaperone- β β bisphosphatase: palmitoyl-[acyl- initiator tRNA phosphate synthase: uridyltransferase: L-tyrosine [DNA] isobutanal sn-glycerol- a ribonucleic acid ribosomal L-allo-threonine oxoguanine in DNA bis(molybdenum a palmitoleoyl-[acp] sn-glycerol -D-glucose 6-phosphate -D-fructofuranose 1-phosphate protein dsbG 2'-deoxyadenosine endopeptidase Syd monoacetylchitobiose- hydrolase: treC α α lactose (S)-S-oxide (R)-S-oxide diphosphate dITP GTP ADP]-[disordered- YfeO carrier-protein] isomerase: pgi fcl glmU 6-phosphate D-xylulose , -trehalose 3-phosphate protein L11 cofactor) 3-phosphate form scaffold yggF MepH: mepH reductase: fabI tyrosine isobutyraldehyde 5' -> 3' L-allo-threonine sugar-phosphatase: ybiV fructose-1- disulfide protein disulfide hydrolase: chbF 5-phosphate lactose methionine- 3' to 5' reductase: yghA ribonucleoside- ribosomal 7,8-dihydro-8- protein] complex fructose-1,6- D-glucopyranose galactohydrolase: kinase: methionine proofreading acyl-CoA:1-acyl- exonuclease: yciV aldolase: ltaE deoxyinosine triphosphate acyl-[acp]:1-acyl- sugar phosphatase: hxpA phosphatase: yqaB isomerase: oxidoreductase: peptidoglycan DD- β UDP-N-acetyl- melibiose degradation fructose degradation wzc S-sulfoxide sulfoxide sn-glycerol-3- diphosphate protein L11 pyrophosphatase: rdgB oxoguanine bis(molybdenum sn-glycerol-3- bisphosphatase: 6-phosphate GDP- -L-fucose α-D-glucosamine N-acetyl-D-glucosamine glucokinase: glk lacZ reductase: reductase: exonuclease: reductase: DNA non- endopeptidase: a palmitoyl-[acp] D-glucopyranose 6-phosphate D-glucopyranose β polA isobutyraldehyde phosphate 2-O- 3' -> 5' RNA methyltransferase: cofactor) phosphate 2-O- chaperonin sugar phosphatase: yidA sugar-phosphatase: ybiV a proteindsbC dsbC 6-phosphate -D- bisC msrB reductase: ybbO acyltransferase: nrdE nrdF exonuclease: tatD prmA allothreonine glycosylase: guanylyltransferase: acyltransferase: glpX ampH YddA β galactopyranose protein- nucleoside triphosphate mutM mobA molecular phosphosugar sugar phosphatase: hxpA CybB with correct protein disulfide melibiose -D-fructofuranose plsC a methylated acetaldehyde- pyrophosphohydrolase: plsC chaperone fructose-1,6- 1-phosphate tyrosine RNase T lyase (glycine- phosphatase: yigL sugar phosphatase: yidA oxidoreductase: peptidoglycan DD- α α-D-glucopyranose β-D-glucopyranose kinase: etk DNA isobutyraldehyde 1,2-dicis- ribosomal mazG bis(guanylyl ATPase: hscA disulfide bonds Signal transduction pathways -galactosidase: 1-phosphofructokinase: methionine methionine- polymerase: reductase: dkgA ribonucleoside- exonuclease: rnt protein L11 forming): glyA an apurinic site 7,8-dihydro- molybdopterin) cofactor 1-palmitoyl-2- bisphosphatase: fbp endopeptidase: melA sulfoxide (R)-sulfoxide vaccenoyl- diphosphate within DNA 8-oxoguanine palmitoleoyl- a [disordered- an [Fe-S cluster phosphosugar phosphosugar a protein dsbA fruK a [protein]- polB phosphatidate dIMP acyl-carrier protein form [Fe-S] cluster biosynthesis phosphatase: phoA F6P β reductase: reductase: isobutyraldehyde reductase: a nucleoside 5'- sn-glycerol phosphatase: yigL with oxidized mepA D-galactopyranose -D-fructose 1,6- L-tyrosine msrA msrC nrdA nrdB monophosphate acetaldehyde gly scaffold protein] chaperone]-ATP YbjJ Nitrogen Regulation Two-Component System bisphosphate phosphate reductase: yahK 3-phosphate β-D-glucopyranose YqjA murein DD- 3' to 5' phosphosugar disulfide bonds PhoQP Two-Component RcsCDB Two-Component Signal Transduction System EvgSA Two-Component Signal Transduction System UhpBA Two Component RstBA Two-Component PhoRB Two-Component GlrKR Two-Component a 2'- phosphatase: phoA endopeptidase: Aerotactic Two-Component Signal Transduction System met met proofreading isobutanol deoxyribonucleoside Signal Transduction System, NtrBC Two-Component Signal Transduction System Signal Transduction System Signal Transduction System, YpdAB Two-Component Signal Transduction System exonuclease: magnesium-dependent Signal Transduction phosphate-dependent Signal Transduction System 5'-diphosphate β-D-fructofuranose pbpG PII dnaQ System, nitrogen-dependent his asp his721 asp his1137 meso- 2+ his his276 his259 RcsC RcsC-P RcsC-P RcsC EvgS EvgS-P EvgS-P EvgS-P his48 YhdP Mg UhpB UhpB-P RstB RstB-P his213 GlrK GlrK-P his48 Nucleoside and Nucleotide Degradation a nucleoside 5'- YdjK diaminopimelic his PhoR PhoR-P his371 CheA CheA(L)-P CheA CheA(L)-P monophosphate PII RcsD RcsD-P YpdA YpdA-P acid-D-alanyl superpathway of pyrimidine endopeptidase: deoxyribonucleosides degradation adenosine nucleotides superpathway of purine deoxyribonucleosides degradation guanosine nucleotides uracil degradation III degradation II degradation III dacB (3Z)-dodec- D-mannitol (S)-1-pyrroline- dTMP dTTP peptidoglycan peptidoglycan HemX a holo-[EntF a uridine in tRNA (2R,3S)-3- an aldehyde a hexose phosphate α [DNA] YchQ 2'-deoxycytidine uracil 3-enoyl-CoA a protein 1-phosphate 5-carboxylate ser L-seryl-carrier isopropylmalate citrate a myristoyl-[acp] sn-glycerol -D-glucose 6-phosphate tetrapeptide, tetrapeptide, his ATP ITP + 3-phosphate his277 NtrB asp56 asp protein] dTTP NtrB-P asp deoxyribonucleoside aconitate NADP -dependent sugar-phosphatase: ybiV sugar-phosphatase: ybiV PII-UMP a PII protein PhoQ PhoQ-P GlrR-P GlrR CheY-P CheY 2'-deoxyguanosine dodecenoyl- ATP-dependent mannitol-1- tRNA- 16 5'-monophosphate pyrophosphatase: yhdE 3' -> 5' glycan chain 1 glycan chain 2 RcsB asp53 asp CheY-P CheY AMP GMP (2S)-2- hydratase A: acnA aldehyde reductase: ybbO asp52 deoxycytidine uracil 4 CoA D- phosphatase: L-serine- dihydrouridine inosine triphosphate sugar phosphatase: hxpA sugar phosphatase: hxpA exodeoxyribonuclease: asp PhoB-P Ap A Clp protease: isopropylmalate phosphatase: yfbR RstA-P RstA PhoB YpdB-P YpdB deaminase: cdd AMP 2'-deoxyadenosine oxygenase: isomerase: hxpB fused DNA- -[holo synthase: dusC pyrophosphatase: rdgB acyl-acp:sn- yqgF RcsAB asp UhpA-P UhpA synthetase: clpP clpA clpX binding hydro-lyase (2- dTTP aldehyde reductase: ahr glycerol-3- sugar phosphatase: yidA sugar phosphatase: yidA YgaM EvgA-P EvgA phosphatase: phoA guanosine-5'- rutA entE fadJ EntF] isopropylmaleate- bifunctional aconitate YoaK deoxyguanosine phosphate transcriptional ligase: 5'-deoxynucleotidase: pyrophosphohydrolase: aldehyde reductase: yahK phosphate 1-O- [protein-PII] thymidine phosphohydrolase: protease: repressor tRNA- nucleoside triphosphate forming): leuC leuD yfdR nudI hydratase B and acyltransferase phosphosugar phosphosugar exodeoxyribonuclease uridylyltransferase: RcsA 2'-deoxyuridine 5'-nucleotidase: umpG phosphorylase: sugar- entF pyrophosphohydrolase: 2-methylisocitrate 3' -> 5": yhbQ CpoB YmfQ YtfJ FlgA SgrR CbrA deoD yrfG (Z)-3-ureidoacrylate 4 3 2 clpP clpX phosphatase: / proline dihydrouridine aldehyde reductase: yqhD (glycerol-3- phosphatase: yigL phosphatase: yigL glnD Ap A ∆ ∆ synthase: dusB mazG dehydratase: acnB thymidine UMP phosphatase: deoxyadenosine peracid synthetase: -cis- ybiV dehydrogenase a seryl-[EntF (2S)-2- 2'-deoxyribonucleoside nucleoside triphosphate phosphate -trans- / 1-pyrroline- L-seryl-carrier isopropylmalate an alcohol acyltransferase) phosphosugar phosphosugar 3' -> 5' ssDNA asp Chemotactic Two-Component Signal Transduction phosphorylase: umpH deaminase: add 5'-nucleotidase: umpG lysU ATP-dependent IMP 5'-monophosphate pyrophosphohydrolase: AraJ NtrC-P enoyl-CoA 5-carboxylate protein] mazG D-threo-isocitrate : plsB phosphatase: phoA phosphatase: phoA exonuclease: tatD YheS NtrC BasSR Two-Component ppnP deoxyadenosine isomerase: Clp protease: mannitol-1- dehydrogenase tRNA- phosphatase: aphA a uridylylated asp51 HprSR Two-Component Signal Transduction System nucleoside 5'- phosphorylase: UMP phosphatase: peroxyureidoacrylate Ap4A clpP clpA dihydrouridine α PII protein PhoP-P PhoP fadB phosphatase: PutA: putA a hexose -D-glucopyranose exodeoxyribonuclease Signal Transduction System CusSR Two-Component his48 monophosphate deoD umpH amidohydrolase: rutB hxpA synthase: dusA thymidine dTMP 1-myristoyl- MarB YdbJ YfaL YcbX YebF OpgD Signal Transduction System his48 thymidine deoxyinosine I: sbcB BarA UvrY Two-Component CheA CheA(L)-P CheA CheA(L)-P phosphatase: aphA serine acyl-carrier protein sn-glycerol his152 phosphorylase: 2'-deoxyinosine phosphorylase: (2E)-dodec- a 5,6- Signal Transduction System uracil deoA nucleoside 5'- protease: clpP dihydrouridine 3-phosphate a 2'-deoxyribonucleoside [DNA] BasS BasS-P phosphorylase: adenosine deoD monophosphate (Z)-3- 2-enoyl-CoA sugar 5'-monophosphate YhhJ his271 carbamate in tRNA AmpE HprS HprS-P deoA phosphatase: aphA peroxyaminoacrylate a peptide phosphatase: glu asp CusS CusS-P yidA NtrC-P NtrC his302 asp718 his816 thymine DpiBA Two-Component BarA BarA-P BarA-P BarA-P α guanosine ArcAB Two-Component Signal adenosine 2-deoxy- -D- aminoacrylate YbgP YjfY YhcA YdhX YjfN YcbF Transduction System, quinone dependent Signal Transduction System TorTSR Signal Transduction System, TMAO dependent deaminase: add ribose 1-phosphate peracid phosphosugar asp asp reductase: rutC phosphatase: CheB-P guanosine YniB CheY-P CheY CheB deoxyribose 1,5- yigL TufB his citrate asp51 phosphorylase: ppnP a quinone sensory histidine BasR-P BasR phosphomutase: CO2 NtrB NtrB-P sensory histidine sensory histidine uracil α inosine aminoacrylate TorS kinase TorS - his443kinase TorS - asp723kinase TorS - his850 2-deoxy- - deoB guanosine phosphosugar phosphorylated phosphorylated phosphorylated asp51 D-ribose 1- YdeP ApaG YdeN DcrB LolA YchO CusR-P CusR phosphorylase: xapA phosphatase: phosphate 2-deoxy-D-ribose aminoacrylate phoA his347 HprR-P HprR RsxD his292 asp576 his717 inosine 5-phosphate RsxA DpiB DpiB-P phosphorylase: ppnP guanosine hydrolase: rutD [protein-PII 2] ArcB ArcB-P ArcB-P ArcB-P asp54 deoxyribose 1,5- phosphorylase: deoD D-mannitol uridylyltransferase: UvrY-P UvrY NarX Two-Component Signal phosphomutase: Transduction System, nitrate dependent deoB inosine 3-oxopropanoate glnD phosphorylase: xapA deoxyribose- phosphate guanine YhcN NapF YncE YbiJ YdeI SfmC 2-deoxy-D-ribose YhiD his399 his399 aldolase: deoC a supercoiled D-sorbitol a [protein]- DNA containing YfeZ 5-phosphate inosine malonic tellurite a [protein] Ser/Thr an unsulfurated L-cysteinylglycine an ADP-sugar an N-modified sn-glycerol 4-nitrobenzaldehyde a cis- sn-glycerol c-di-GMP asp EnvZ Two-Component NarX NarX-P NarX NarX-P phosphorylase: deoD duplex DNA 6-phosphate L-tyrosine cys cys a base with lesion a palmitoyl-[acp] Signal Transduction semialdehyde GTP [sulfur carrier] XTP aminoacyl-[tRNA] 3-phosphate vaccenoyl-[acp] 3-phosphate asp57 TorR-P TorR reductase: ydfG phosphate System, osmotic responsive guanine tellurite sorbitol-6- protein cysteinylglycine ADP-sugar 4-nitrobenzaldehyde c-di-GMP GlnK uridylyl-[GlnK] DpiA-P DpiA CreCB Two-Component deaminase: guaD 5' to 3' ATP- phosphotyrosine- kinase: yeaG L-cysteine L-cysteine dipeptidase: pepN diphosphatase: DNA reductase: dkgB phosphodiesterase: pdeC Signal Transduction System hypoxanthine acetaldehyde D-glyceraldehyde 3-phosphate reductase: diguanylate phosphatase: desulfurase: xanthosine triphosphate peptidyl- deoxyribose- lpd dependent hxpB protein desulfidase: cyuA pyrophosphatase: rdgB nudE tRNA containing acyl-acp:sn- acyl-acp:sn- MlaC FtsP OsmY YgiW YfdX YfcS asp54 his malonic cyclase: dgcN DNA sufS aldehyde reductase: yqhD MreD phosphate semialdehyde phosphatase: etp cysteinylglycine hydrolase: a base glycerol-3- glycerol-3- cyclic di-GMP YigG ArcA-P ArcA EnvZ EnvZ-P aldolase: xanthine helicase: serine/ L-cysteine dipeptidase: pepB arfB with lesion phosphate 1-O- phosphate 1-O- phosphodiesterase: pdeF his265 deoC acetaldehyde reductase: rutE diguanylate recD threonine desulfhydrase: tnaA nucleoside triphosphate ADP-sugar hydrolase: aldehyde reductase: yahK CreC CreC-P asp59 tellurite sugar- cysteine acyltransferase acyltransferase asp59 hypoxanthine dehydrogenase cyclase: dgcC protein-tyrosine protein pyrophosphohydrolase: pyrophosphatase: mug c-di-GMP glutamine NarL-P NarL reductase: phosphatase: desulfurase: mazG cysteinylglycine (glycerol-3- aldehyde reductase: ahr (glycerol-3- NarP-P NarP hydroxylase: (acetylating) xanthine:NAD+ phosphatase: kinase: srkA nudF + synthetase 3-hydroxypropanoate narY ybiV wzb L-cysteine iscS dipeptidase: pepA peptidyl- phosphate phosphate phosphodiesterase: pdeH deadenylase: xdhA xdhB xdhC : mhpF oxidoreductase: narZ narV diguanylate desulfhydrase: cysM tRNA acyltransferase) NADP -dependent acyltransferase) glnE CpxAR Two-Component D-glyceraldehyde xdhA xdhB xdhC cyclase: dgcM ATP- a [protein] (L-serine/L- XMP a modified a DNA containing aldehyde reductase: ybbO YahO YmgD YghF ElfD Ag43 YbcL YceO KdpDE Two-Component DcuSR Two-Component acetaldehyde a sulfurated cysteinylglycine α hydrolase: an apurinic/ : plsB : plsB c-di-GMP YdbH Signal Transduction System 3-phosphate dependent sorbitol-6- threonine) phosphate L-cysteine [sulfur carrier] ala an -D-aldose AMP nucleobase Signal Transduction System, Signal Transduction System, xanthine acetaldehyde DNA phosphatase: protein-tyrosine dipeptidase: pepD 1-phosphate pth apyrimidinic site 4-nitrobenzyl alcohol phosphodiesterase: pdeR dicarboxylate-dependent dehydrogenase: tellurite diguanylate phosphatase: desulfhydrase: cysK potassium-dependent urate cyclase: dgcZ helicase: hxpA an uncharged 1-palmitoyl- 1-cis-vaccenoyl- AtoSC Two-Component OmpR-P OmpR acetaldehyde adhE reductase: recQ pphB gly cys an N-modified acyl-carrier protein sn-glycerol acyl-carrier protein sn-glycerol- c-di-GMP Signal Transduction System xanthine:NAD+ narG L-cysteine amino acid tRNA phosphodiesterase: dosP NlpE his his dehydrogenase diguanylate 3-phosphate 3-phosphate ZraSR Two-Component (acetylating) oxidoreductase: purine ribonucleosides degradation narH narI sugar desulfhydrase: malY CvpA a [glutamine Signal Transduction System KdpD KdpD-P asp54 DcuS DcuS-P cyclase: dgcT protein-tyrosine YdhP YqiH Ivy FlgJ LolB Asr HdeB a [glutamine- CpxP : mhpF xdhA xdhB xdhC acetyl-CoA helicase: phosphatase: L-cysteine c-di-GMP 4synthetase]-O synthetase]- CreB-P CreB 0 yidA phosphatase: -(5'-adenylyl) spermidine acetoacetate BaeSR Two-Component QseBC Two-Component Te [+ 2 isozymes] dnaB pphA phosphodiesterase: pdeL L-tyrosine 2+ desulfhydrase: metC -L-tyrosine 2+ Signal Transduction System Signal Transduction System, Pb urate c-di-GMP a single phosphosugar 5'-phosphoguanylyl(3'->5')guanosine Zn quorum sensing related acetaldehyde adenosine stranded DNA a [protein]- pyruvate NarQ Two-Component Signal dehydrogenase: phosphatase: L-tyrosine YicH his248 AtoS AtoS-P his250 Transduction System, nitrate dependent adhE YagU CpxA CpxA-P BaeS BaeS-P his246 pyrimidine ribonucleosides yigL YobA McbA CsgC FlhE YbcH RclB QseC QseC-P adenosine his254 degradation pyrimidine deoxyribonucleotides dephosphorylation glutamine synthetase asp his370 his370 acetyl-CoA deaminase: ZraS ZraS-P DcuR-P DcuR NarQ NarQ-P NarQ NarQ-P add phosphosugar adenylyltransferase: cytidine phosphatase: glnE asp dCTP phoA glu GltS glu KdpE-P KdpE pyrophosphohydrolase: nudI YbaT inosine guanosine cytidine D-sorbitol FimC YraP YraI HdeA Ais EcpE deaminase: nucleoside triphosphate glutamine asp51 AtoC-P AtoC QseB-P QseB cdd pyrophosphohydrolase: inosine guanosine synthetase: pseudouridine mazG phosphorylase: phosphorylase: glnA asp56 asp61 asp59 asp59 adenosine asp asp degradation uridine ppnP ppnP GltP glu gln CpxR-P CpxR ZraR-P ZraR BaeR-P BaeR NarL-P NarL NarP-P NarP nucleotides dCTP dCMP xanthosine adenosine YghJ glu glu degradation III xanthosine adenosine inosine guanosine pseudouridine phosphorylase: SecM YhjJ YehC YadV RcnB ZinT uridine dUTP phosphorylase: phosphorylase: phosphorylase: glutamate / pseudouridine phosphorylase: ppnP ppnP xapA xapA AMP ppnP pyrophosphohydrolase: nudI asp aspartate asp kinase: psuK AMP FadK cis- glu ABC glu vaccenate transporter pseudouridine AMP deoxyuridine xanthosine adenosine inosine guanosine 5'-phosphate nucleosidase: uridine triphosphatase: dut phosphorylase: phosphorylase: phosphorylase: phosphorylase: ppnN phosphorylase: xapA deoD deoD deoD PliG OpgG HlyE MalM Ggt EfeO udp nucleoside triphosphate L-glutamine pseudouridine- AMP pyrophosphohydrolase: cis- gln ABC gln mazG AMP FadD transporter 5'-phosphate nucleosidase: vaccenate glycosidase: amn α-D-ribose- uracil dUTP dUMP psuG 1-phosphate adenine S-methyl-5'-thioadenosine α-D-ribose- degradation IV α 1-phosphate NrfG uracil -D-ribose 1,5- 5-hydroxy-CTP HemY phosphomutase: diphosphohydrolase: nudG deoB S-methyl-5'- α-D-ribose 1,5- 5-hydroxy-CTP 5-hydroxy-CMP thioadenosine an ion an ion phosphomutase: an organosulfur compound OmpF an organosulfur compound D-ribose 5- 5'-methylthioadenosine deoB a short-chain carboxylate a short-chain carboxylate phosphate nucleosidase: mtn [+ 27 more] [+ 27 more] YafT D-ribose 5- YjgX MTR phosphate an ion an ion 4-amino-4- an organosulfur compound PhoE an organosulfur compound deoxy-α-L- a short-chain carboxylate a short-chain carboxylate 1,6- 2-O-(6- [+ 27 more] [+ 27 more] arabinopyranosyl anhydro- α α ferric phosphate + an aliphatic ditrans,octacis N-acetyl-D- + 2'-deoxycytidine , - phospho- enterobactin D-mannitol YicJ 2+ + N-acetyl-β- maltotetraose β trehalose 6- α YbjP 4-aminobutanoate 2+ a drug nitrite MQ nalidixate NAD MQH2 nitrite MQ sulfonate D-sorbitol galactitol 1- muramate 6- -D-cellobiose 6'-phosphate Li 2'-deoxyadenosine -D- complex a glycerophosphodiester D-sorbitol 6-phosphate 1-phosphate Co2+ deoxycholate 2+ K molybdate -undecaprenyl ethidium 6 thymine L-idonate D-glucarate D-glucarate 2-dehydro- N-(4- β-D-cellobiose 6'-phosphate 2+ 2+ α-D-galactofuranose + cefoperazone 6-phosphate muramate phosphate phosphate maltotriose N,N'-diacetylchitobiose 6'-phosphate AMP adenine adenine AMP xanthosine phosphate mannosyl)- sn-glycerol 3-phosphate D-mannitol 1-phosphate an ion an ion 2+ Zn nalidixate tetraphenylphosphonium carbonylcyanide m-chlorophenylhydrazone Ni phosphate sulfadiazine 6 xanthine thymidine 5-dehydro-D-gluconate sn-glycerol salicin 6-phosphate glu Ni 2 2 β lipid II (meso E. coli O16 a D- 2 D-sorbitol 6-phosphate 6-sulfo-D- N -(D-psicosyl)-L-lysine aldehydo-L- maltose methyl-β-D-galactoside D-glucopyranose xanthine guanine guanine methyl-β-D-galactoside guanosine D-glucosamine 6-phosphate maltose D-fructuronate D-galactarate D-galactarate 3-deoxy-D- aminobenzoyl) Mg 2+ Zn 2+ spermidine acetoacetate MQH nitrate deoxycholate MQ NADH MQH nitrate -D-galactofuranose K L-arabinose MQH + + chloride chloride choline pseudouridine xanthine xanthine [+ 6 more] D-gluconate D-glycerate an organosulfur compound an organosulfur compound Mg norfloxacin diaminopimelate antigen monomer- glucoronoside D-mannitol 1-phosphate a drug quinovose N -(D-fructosyl)-L-lysine melibiose D-galactopyranose D-galactopyranose uracil uracil urate hypoxanthine hypoxanthine melibiose inosine N-acetyl-D-glucosamine 6-phosphate D-glucopyranose D-gluconate D-gluconate D-gluconate (R)-glycerate (R)-glycerate gluconate 3-phosphate 2-nitroimidazole -L-glutamate arbutin-6-phosphate OmpC Zn Zn cystine a drug L-arabinose K K [+ 2 more] galactonate a short-chain carboxylate a short-chain carboxylate containing) diphosphoundecaprenol a drug [+ 27 more] [+ 27 more]

multidrug/ + sorbitol- 2+ multidrug aliphatic K molybdate undecaprenyl- putative galactitol- N-acetylmuramic galactitol- N-acetylmuramic N,N'- trehalose- ferric sn-glycerol 3-phosphate mannitol- Zn ABC spermidine galactofuranose Ni(2+) ABC sulfonate α ABC maltose ABC enterobactin specific PTS specific YmgF GadC YehR MgtA CorA transporter ZntA ZntB ZitB AtoE YihG YmfE NrfF YegT YcaI YdgK YdhI YciB YijE MdtK NRA efflux pump NDH-1 NRZ ABC transporter MurJ YdeA RfbX UidB TrkG AraE transporter ABC transporting HYD2 KefB KefC ABC phosphate- -L- exporter ClcB ClcA specific PTS MtlA acid-specific specific PTS acid-specific EmrE BetT YihO FrlA LgoT transporter diacetylchitobiose- MelB MglBAC GalP PsuT UraA RutG FadK AdeP AdeQ FadD UacT XanQ XanP GhxP GhxQ MelB XapB NupC NepI NagE MalX specific PTS IdnT GntP GntT GntU GudP GarP MngA ABC KdgT / glycerophosphodiester GlpT PTS enzyme NimT YdjX YcjF HokE YbeX Kch YgcS AbgT YgdR CreD YdhU OrtT SapA YghQ IbsD YsaB YhiM YbfB AscF YajG YidK YbcI efflux pump EmrAB-TolC transporter P-type ATPase transporter Ara4N flippase YbhFSR enzyme II PTS enzyme II enzyme II PTS enzyme II specific PTS enzyme II enzyme II transporter ABC transporter enzyme II II CmtBA

2+ 6 2+ 2+ + β β 2+ a D- D-sorbitol 6-sulfo-D- 6 aldehydo-L- methyl- -D-galactoside D-glucopyranose uracil methyl- -D-galactoside D-glucosamine maltose D-fructuronate α β Co 2+ α L-arabinose 2+ N -(D-psicosyl)-L-lysine thymine xanthine 2'-deoxycytidine L-idonate D-gluconate D-gluconate D-glucarate D-glucarate 2-O-( -D- 2-dehydro- N-(4- -D-cellobiose Mg 2+ Zn acetoacetate -D-galactofuranose glucoronoside K H2 + chloride chloride D-mannitol choline quinovose galactonate D-galactopyranose D-galactopyranose pseudouridine oleate oleate xanthine xanthine melibiose N-acetyl-D-glucosamine D-glucopyranose D-gluconate Ni 2+ 2+ + + N -(D-fructosyl)-L-lysine maltotetraose β xanthine urate α α 5-dehydro-D-gluconate D-galactarate D-galactarate mannosyl)- 3-deoxy-D- aminobenzoyl) salicin Zn Zn deoxycholate β-D-galactofuranose lipid II (meso L-arabinose E. coli O16 Ni K D-sorbitol galactitol N-acetyl-D- ethidium maltotriose -D-cellobiose melibiose adenine adenine xanthosine 2'-deoxyadenosine , - a glycerophosphodiester sn-glycerol D-sorbitol 2-nitroimidazole glu Mg Zn cystine diaminopimelate antigen monomer- an aliphatic K K molybdate 1,6- muramate N,N'-diacetylchitobiose uracil guanine guanine thymidine guanosine trehalose D-gluconate (R)-glycerate (R)-glycerate D-glycerate ferric gluconate D-mannitol a drug -L-glutamate arbutin a drug tetraphenylphosphonium nalidixate anhydro- sulfadiazine maltose + sn-glycerol 3-phosphate 3-phosphate D-mannitol 4-aminobutanoate norfloxacin containing) diphosphoundecaprenol sulfonate a drug Li hypoxanthine hypoxanthine [+ 6 more] inosine enterobactin nalidixate carbonylcyanide m-chlorophenylhydrazone 4-amino-4- cefoperazone N-acetyl-β- spermidine a drug deoxycholate deoxy-α-L- muramate [+ 2 more] complex arabinopyranosyl phosphate ditrans,octacis -undecaprenyl phosphate Copyright SRI International 1999-2018, Marine Biological Laboratory 1998-2001, DoubleTwist Inc 1998-1999. All Rights Reserved. This diagram was automatically generated by SRI International Pathway Tools version 22.5, authors S. Paley and P.D. Karp.