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Generate Metabolic Map Poster Authors: Peter D. Karp Suzanne Paley Julio Collado-Vides John L Ingraham Ingrid Keseler Markus Krummenacker Cesar Bonavides-Martinez Robert Gunsalus An online version of this diagram is available at BioCyc.org. Biosynthetic pathways are positioned in the left of the cytoplasm, degradative pathways on the right, and reactions not assigned to any pathway are in the far right of the cytoplasm. Transporters and membrane proteins are shown on the membrane. Carol Fulcher Ian Paulsen Socorro Gama-Castro Robert LaRossa Periplasmic (where appropriate) and extracellular reactions and proteins may also be shown. Pathways are colored according to their cellular function. EcoCyc: Escherichia coli K-12 substr. MG1655 Cellular Overview Connections between pathways are omitted for legibility. Anamika Kothari Amanda Mackie Alberto Santos-Zavaleta succinate phosphate succinate N-acetyl-DL-methionine + L-ornithine glutathione + L-methionine S-oxide D-fructofuranose γ Ag+ molybdate ferroheme b L,L-homocystine asp lys cys L-alanyl- -D- D-mannopyranose 6-phosphate 2+ 2+ H D-methionine 2-deoxy-D-glucose succinate formate formate succinate D-tartrate putrescine agmatine cadaverine L-tartrate D-fructofuranose 6-phosphate + nitrate nitrate Cu thiosulfate deoxycholate L,L-homocystine D-cystine D-cycloserine methyl β-D-glucoside putrescine asp spermidine (S)-2-hydroxybutanoate (S)-2-hydroxybutanoate arg L-homoserine lactone magnesium hydrogenphosphate magnesium hydrogenphosphate antimonous acid glutamyl-meso- Co2+ Cd2+ lactulose poly-β-1,6- met cob(I)inamide 2,3-dioxo- D-glucosamine (2R,4S)-2-methyl-2,3,3,4- L-homoserine + H + sulfate phosphate D-cystine β FAD non-specific D-ala non-specific salicin methyl α-D-glucoside (2R,4S)-2-methyl-2,3,3,4- fumarate fumarate putrescine (S)-lactate (S)-lactate L-ornithine arg lys lys L-homoserine O-acetyl-L-serine O-acetyl-L-serine antimonous acid calcium hydrogenphosphate calcium hydrogenphosphate urea thr diaminopimelate L-glyceraldehyde 3-phosphate Cd2+ Zn2+ non-specific melibiose α ala N-acetyl-D- 4-hydroxybenzoate phosphate a 2,3,4- a 2,3,4- lanthionine 1-( -D glutathione enterobactin L-ascorbate [+ 4 more] glycolate asp fumarate CO2 CO2 citrate putrescine formate thr a polypeptide L-arabinose tyr succinate H 2+ methyl- -D-galactopyranoside nitrite nitrite Cu [+ 2 more] L-galactose β β cob(I)alamin L-cystine [+ 3 more] FMN ion/solute L-gulonate ala ion/solute pyridoxamine pyridoxine arbutin D-glucopyranose tetrahydroxytetrahydrofuran tetrahydroxytetrahydrofuran (S)-malate (S)-malate ser glycolate glycolate thr cys cys arsenite phosphate zinc hydrogenphosphate DL-glyceraldehyde D-glucopyranose 6-phosphate D-ribopyranose α-lactose α-lactose 2+ Mn Fe ion/solute α-lactose a lipopolysaccharide glucosamine N-acetyl- -D-glucosamine-1,6-anhydro-N-acetyl- -D-muramate shikimate cyanate saturated saturated a C4-dicarboxylate ammonium ribofuranosyl) (R)- asn 4-aminobutanoate a quaternary amine 2-oxoglutarate tellurite fumarate succinate succinate fumarate putrescine putrescine putrescine thr pyruvate L-canavanine sulfate lys cadaverine trp phe acetate ser ser pro glycine betaine Fe Mn2+ D-serine nitrite melibiose nitrite propanoate L-fucose a lyso-phosphatidylglycerol GlcNAc-1,6-anhMurNAc-L-Ala-γ-D-Glu-DAP-D-Ala fatty acid fatty acid S-sulfo-L-cysteine cytosine orotate nicotinamide [+ 3 more] pantothenate pro D-glucopyranose acetate fumarate fumarate (R)-lactate (R)-lactate arg trp arsenate [+ 3 more] [+ 3 more] succinate pro [+ 3 more] Fe [+ 2 more] melibionate D-arabinose a 2-acyl-1-lyso-phosphatidylethanolamine L-methionine/ heme spermidine lysine / glutathione murein ATP synthase ATP synthase copper/ tripartite vitamin phosphate glutathione 2,3-diketo-L-+ L-ascorbate mannose- glucose- Autoinducer- putrescine putrescine arginine / / L-cysteine arabinose thiosulfate/ cytochrome D-methionine trafficking cystine ABC transport of pyridoxine preferential tripeptide ribose ABC / thiamin / thiamin silver efflux pump AmpG ShiA AaeAB B12 ABC NDH-1 ABC YjbB CynX FadD FadK TcyP CodB DctA AmtB PnuC ABC YeeO MscS gulonate:Na EntS CycA PanF MscL specific PTS AnsP GabP PPIII specific PTS BglF specific PTS KgtP ActP 2 ABC TqsA DcuA DauA DcuC DcuC DcuB FDH-O Fdh-N CitT ABC ABC PlaP PuuP DcuA DcuB PotE FocA TdcC LldP GlcA BtsT PotE ornithine ArgO AdiC CysZ CadB LysO LysP CadB RhtB RhtA TatABC EamB EamA ABC ABC TnaB AroP ArsB PitB PitA GlpF RhtC SatP TtdT UhpT SetB SetA SstT SdaC PutP ProP PntAB FeoB ZupT MntH FieF DsdX MscK NirC LacY MelB NarK NarK NarU AlaE PutP CopA sulfate ABC MsbA FucP LplT bo3 ubiquinol CbdAB PgaCD EmrKY-TolC ABC system transporter transporter transporter transporter symporter enzyme II pyridoxamine transporter enzyme II enzyme II transporter exporter transporter ABC ABC exporter transporter ABC transporter triphosphate triphosphate export transporter oxidase transporter CcmABCDE transporter transporter CydDC transporter synthase synthase system YdeE 2+ + + β2 FAD non-specific non-specific (2R,4S)-2-methyl-2,3,3,4- L-homoserine lactone O-acetyl-L-serine O-acetyl-L-serine antimonous acid α-lactose α-lactose 2+ Cd2+ non-specific a lipopolysaccharide poly-UQHH O-1,6-2 4-hydroxybenzoate enterobactin formate L-homoserine a polypeptide H 2+ 2+ Cu cytochrome β β phosphate cytosine 1-(β-D FMN ion/solute ion/solute tetrahydroxytetrahydrofuran lys L-homoserine cys cys arsenite thr 2+ Zn2+ ion/solute methyl-α-D-galactopyranoside ala L-galactose N-acetyl-D- N-acetyl- -D-glucosamine-1,6-anhydro-N-acetyl- -D-muramate L,L-homocystine a C4-dicarboxylate D-cycloserine (R)- a quaternary amine methyl β-D-glucoside 6-phosphate glycolate asp succinate asp asp (S)-2-hydroxybutanoate (S)-2-hydroxybutanoate L-canavanine thr tyr magnesium hydrogenphosphate magnesium hydrogenphosphate antimonous acid acetate D-mannopyranose 6-phosphate glycine betaine Co2+ Mn lactulose + a lyso-phosphatidylglycerol 2 2 γ shikimate UQ NADH cyanate diphosphate diphosphate ammonium 4-aminobutanoate 2-oxoglutarate fumarate fumarate fumarate MQ MQ citrate putrescine putrescine putrescine ser pyruvate sulfate cadaverine thr succinate Fe Fe + nitrite nitrite nitrite nitrite propanoate UQH O glucosamine bd-I ubiquinol deoxycholate GlcNAc-1,6-anhMurNAc-L-Ala- -D-Glu-DAP-D-Ala D-cystine L,L-homocystine orotate ribofuranosyl) D-ala pantothenate asn pyridoxamine pyridoxine pro salicin 6-phosphate α tellurite succinate fumarate putrescine fumarate D-tartrate (S)-lactate (S)-lactate L-ornithine arg arg lys lys trp phe calcium hydrogenphosphate calcium hydrogenphosphate urea succinate D-fructofuranose 6-phosphate D-ribopyranose ser ser pro pro Cd2+ Fe D-serine melibiose melibiose Ag+ L-fucose a 2-acyl-1-lyso-phosphatidylethanolamine cob(I)inamide + 2,3-dioxo- L-ascorbate methyl -D-glucoside 6-phosphate (2R,4S)-2-methyl-2,3,3,4- thr 2 oxidase ferroheme b nicotinamide D-fructofuranose 6-phosphate acetate fumarate (S)-malate glutathione L-arabinose trp + H α melibionate molybdate D-arabinose UQH 2 NAD UQH2 L-cystine D-cystine glutathione ala arbutin-6-phosphate 2 MQH2 succinate putrescine fumarate spermidine glycolate glycolate putrescine agmatine phosphate zinc hydrogenphosphate DL-glyceraldehyde L-tartrate γ L-glyceraldehyde 3-phosphate Mn -lactose nitrate Cu O H2O 2 UQ N-acetyl-DL-methionine cob(I)alamin phosphate L-gulonate 6-phosphate 2-deoxy-D-glucose 6-phosphate D-glucopyranose 6-phosphate tetrahydroxytetrahydrofuran succinate MQH cadaverine cys L-alanyl- -D- H nitrate thiosulfate UQ O TorY L-methionine S-oxide S-sulfo-L-cysteine lanthionine [+ 3 more] D-glucopyranose 6-phosphate (S)-malate putrescine (R)-lactate (R)-lactate L-ornithine arsenate [+ 3 more] [+ 3 more] glutamyl-meso- D-glucopyranose 6-phosphate [+ 3 more] [+ 2 more] [+ 3 more] D-glucosamine 6-phosphate lys sulfate H2O UQ D-methionine [+ 4 more] diaminopimelate [+ 2 more] met succinate arg succinate 2'-deoxyuridine 3'- phosphate 2'-UMP α α α cellulose aminoacetone 2-phenylethylamine monophosphate a 1,4- -D-glucan , -trehalose YjbH YohC 2'UMP aminoacetone phenylethylamine 2'-deoxyuridine 3'- α-amylase: trehalase: treA Cofactor, Prosthetic Group, Electron Carrier, and Vitamin Biosynthesis Detoxification C1 Compound Utilization phosphatase: oxidase: tynA oxidase: tynA monophosphate malS β-D-glucopyranose α-D-glucopyranose superpathway of L-arginine Amino Acid Degradation and Assimilation N,N'- ChiP N,N'- L-lysine degradation I L-cysteine + α diacetylchitobiose diacetylchitobiose and L-ornithine degradation L-arginine degradation L-tryptophan α 5,6- CTP a [lipoyl-carrier a pyrimidine β UDP-N-acetyl- phoA methylglyoxal phenylacetaldehyde phosphatase: aphA maltohexaose a 1,4- -D-glucan biotin biosynthesis I degradation II II (AST pathway) nigerose cyanate -lactose formyl-CoA oxalate citrate dihydrothymine an acetyl ester an Fe(III)-siderophore NAD (R)-lipoate melibionate maltohexaose D-glucopyranose nucleoside N,N'-diacetylchitobiose 3-O- -D-galactopyranosyl-D-arabinose α-D-glucosamine N-acetyl-D-glucosamine superpathway of ubiquinol- superpathway of menaquinol-8 biosynthesis I superpathway of coenzyme A biosynthesis I (bacteria) superpathway of adenosylcobalamin salvage from cobinamide I superpathway of heme b biosynthesis from uroporphyrinogen-III Fermentation mixed acid fermentation degradation II superoxide protein]-L-lysine L-arginine uridine 2'-deoxyuridine MrdB 8 biosynthesis (prokaryotic) superpathway of tetrahydrofolate biosynthesis formaldehyde oxidation biotin ATP α ABC a cellodextrin guanylyl molybdenum cytidylyl molybdenum Secondary Metabolite Biosynthesis (via pyruvate) radicals arsenate
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