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The Biogenesis and Chemistry of Sesquiterpene Lactones 321 The Biogenesis and Chemistry of Sesquiterpene Lactones 321 Acknowledgements: Parts of this work were supported by Grant Number 1-R01-CA- 19800, awarded by the National Cancer Institute, DHEW and by a grant from the National Science Foundation (DEB-76-20585). We are indebted to Professor WERNER HERZ whose contributions to this review went far beyond his editorial duties. References 1. ABE, Y., T. HARUKAWA, H. ISHIKAWA, T. MIKI, M. SUMI, and T. TOGA: Santonin. I. The Synthesis of Two Optically Inactive Stereoisornerides of Santonin. J. Arner. Chern. Soc. 75, 2567 (1953). 2. ------ The Synthesis of New Stereoisorners of Santonin. J. Arner. Chern Soc. 78, 1416 (1956). 3. ABE, N., R. ONODA, K. SHIRAHATA, T. KATO, M. C. WOODS, Y. KITAHARA, K. Ro, and T. KURIHARA: The Structures of Bakkenolides-B, -C and -D as Determined by the Use of a Nuclear Overhauser Effect. Tetrahedron Letters 1968, 1993. 4. ABE, N., R. ONODA, K. SHIRAHATA, T. KATO, M. C. WOODS, and Y. KITAHARA: The Structure of Bakkenolide-A. Tetrahedron Letters 1968, 369. 5. ABDEL-BASET, Z. H., L. SOUTHWICK, W. G. PADOLINA, H. YOSHIOKA, T. J. MABRY, and S. B. JONES, JR.: Sesquiterpene Lactones: A Survey of 21 United States Taxa from the Genus Vernonia (Cornpositae). Phytochern. 10,2201 (1971). 6. ABU-SHADY, H., and T. O. SOINE: The Chemistry of Ambrosia maritima L. The Isolation and Preliminary Characterization of Ambrosin and Darnsin. J. Arner. Pharm. Assoc. 42, 387 (1953). 7. ACHARI, R. G., W. E. COURT, and F. NEWCOMBE: Biosynthesis of the isovaleryl and senecioyl moieties of tropane alkaloids. Planta Med. 22, 38 (1972); Chern. Abstr. 77, 149747W (1972). 8. ADAMS, R., and W. HERZ: Helenalin. I. Isolation and Properties. J. Arner. Chern. Soc. 71, 2546 (1949). 9. -- Helenalin. III. Reduction and Dehydrogenation. J. Arner. Chern. Soc. 71, 2554 (1949). 10. AGAFONOVA, N. V., L. E. KUSHNIR, A. D. KUZOVKOV, A. I. SHRETER, and M. G. 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