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Plantaplanta Medica an Internationalmedica Journal of Natural Products and Medicinal Plant Research PlantaPlanta Medica An InternationalMedica Journal of Natural Products and Medicinal Plant Research Editor-in-Chief Advisory Board Luc Pieters, Antwerp, Belgium Giovanni Appendino, Novara, Italy John T. Arnason, Ottawa, Canada Senior Editor Yoshinori Asakawa, Tokushima, Japan Lars Bohlin, Uppsala, Sweden Adolf Nahrstedt, Mnster, Germany Gerhard Bringmann, Wrzburg, Germany Reto Brun, Basel, Switzerland Review Editor Mark S. Butler, Singapore, R. of Singapore Matthias Hamburger, Basel, Switzerland Ihsan Calis, Ankara, Turkey Salvador Caigueral, Barcelona, Spain Editors Hartmut Derendorf, Gainesville, USA Wolfgang Barz, Mnster, Germany Verena Dirsch, Vienna, Austria Rudolf Bauer, Graz, Austria Jrgen Drewe, Basel, Switzerland Roberto Maffei Facino, Milan, Italy Veronika Butterweck, Gainesville FL, USA Alfonso Garcia-Pieres, Frederick MD, USA Jo¼o Batista Calixto, Florianopolis, Brazil Rolf Gebhardt, Leipzig, Germany Thomas Efferth, Heidelberg, Germany Clarissa Gerhuser, Heidelberg, Germany Jerzy W. Jaroszewski, Copenhagen, Denmark Jrg Gertsch, Zrich, Switzerland Ikhlas Khan, Oxford MS, USA Simon Gibbons, London, UK De-An Guo, Beijing, China Wolfgang Kreis, Erlangen, Germany Leslie Gunatilaka, Tuscon, USA Irmgard Merfort, Freiburg, Germany Solomon Habtemariam, London, UK Kurt Schmidt, Graz, Austria Andreas Hensel, Mnster, Germany Thomas Simmet, Ulm, Germany Werner Herz, Tallahassee, USA Kurt Hostettmann, Geneva, Switzerland Hermann Stuppner, Innsbruck, Austria Peter J. Houghton, London, UK Yang-Chang Wu, Kaohsiung, Taiwan Jinwoong Kim, Seoul, Korea Yang Ye, Shanghai, China Gabriele M. Knig, Bonn, Germany Ulrich Matern, Marburg, Germany Editorial Offices Matthias Melzig, Berlin, Germany Claudia Schrer, Basel, Switzerland Dulcie Mulholland, Guildford, UK Eduardo Munoz, Cordoba, Spain Tess de Bruyne, Antwerp, Belgium Kirsi-Marja Oksman-Caldentey, Espoo, Finland Ana Maria de Oliveira, S¼o Paulo, Brazil Nigel B. Perry, Dunedin, New Zealand Joseph Pfeilschifter, Frankfurt, Germany Peter Proksch, Dsseldorf, Germany Thomas Schmidt, Mnster, Germany Volker Schulz, Berlin, Germany Hans-Uwe Simon, Bern, Switzerland Leandros Skaltsounis, Athens, Greece Georg Thieme Verlag KG Han-Dong Sun, Kunming, China Stuttgart · New York Benny K. H. Tan, Singapore, R. of Singapore Rdigerstraße 14 Ren Xiang Tan, Nanjing, China D-70469 Stuttgart Deniz Tasdemir, London, UK Postfach 301120 Nunziatina de Tommasi, Salerno, Italy Arnold Vlietinck, Antwerp, Belgium D-70451 Stuttgart Angelika M. Vollmar, Mnchen, Germany Heikki Vuorela, Helsinki, Finland Thieme Publishers Jean-Luc Wolfender, Geneva, Switzerland 333 Seventh Avenue De-Quan Yu, Beijing, China New York, NY 10001 PlantaPlanta Medica An InternationalMedica Journal of Natural Products and Medicinal Plant Research 55th International Congress and Annual Meeting of the Society for Medicinal Plant Research September 2–6, 2007, Graz, Austria Abstracts Organizer: The Society for Medicinal Plant Research Chairman: Rudolf Bauer Issue Editors: Franz Bucar Rudolf Bauer Issue Co-Editors: Wolfgang Schhly Eva Wenzig Karin Wlkart Technical Assistant: Marlene Monschein Georg Thieme Verlag KG Stuttgart · New York Rdigerstraße 14 D-70469 Stuttgart Postfach 30 11 20 D-70451 Stuttgart Thieme Publishers 333 Seventh Avenue New York, NY 10001 Planta Medica Contents73 (2007), 797–1036, No. 9, August 9 797 Editorial 820 WS 5: Nasal innate and adaptive immune responses and their 798 Plenary lectures influence by herbal 800 Keynote lectures preparations 803 Short lectures 821 WS 6: State of the art in clinical and 814 Workshops preclinical studies with EPsÒ 7630 (UmckaloaboÒ) 814 Workshop for Young Researchers 822 WS 7: Echinacea: Update on current 818 WS 1: Importance of HMPC research community monographs and community list for the 824 Poster Presentations marketing authorisation and 824 1. Anti-inflammatory and registration of herbal medicinal immunomodulatory active natural products in Europe products (Permanent Committee on Regulatory Affairs on Herbal 848 2. Natural products with antimicrobial activity Medicinal Products) 892 3. Analysis and biopharmaceutics of 818 WS 2: Pharmacokinetics of herbal herbal medicinal products and medicinal products – useful or herbal drugs not? (Permanent Committee on 919 4. Medicinal plants in animal Manufacturing and Quality healthcare Control of Herbal Remedies) 923 5. Phytochemistry and structure 819 WS 3: Models for testing addictive elucidation of natural products behaviour 960 6. Pharmacology, toxicology and (Permanent Committee on clinical studies of natural products Biological and Pharmacological Activity of Natural Products) 1010 7. Other related topics 819 WS 4: Identification and 1025 Author’s Index authentication of plant starting 1035 Imprint materials (Permanent Committee on Breeding and Cultivation of Medicinal Plants) 55th International Congress and Annual Meeting of the Society for Medicinal Plant Research September 2 – 6, 2007, Graz, Austria Abstracts Editorial The Society for Medicinal Plant Research (GA) is going to organize its 55th Annual Meeting and International Congress in Graz/Austria. It will be held at the Karl-Franzens-University of Graz and in the Convention Center Graz. As the Chairman of the congress and also currently as President of GA and Head of the Institute of Pharmaceutical Sciences of University of Graz, I am very happy that our congress has been accepted so well and that so many scientists dealing with medicinal plants research are gathering 2007 in Graz. The main topics of the congress are – Anti-inflammatory and immunomodulatory active natural products – Natural products with antimicrobial activity – Analysis and biopharmaceutics of herbal medicinal products 797 – Traditional herbal medicinal products – Medicinal plants in animal healthcare However, scientific contributions of other topics related to medicinal plant research will also be presented. I am very happy, that Prof. Dr. H.R.H. Princess Chulabhorn Mahidol has accepted to give the opening lecture of the congress. Moreover, seventeen distinguished scientists have agreed to give plenary or keynote lectures. Besides, 34 short lectures and more than 650 poster presentations have been accepted. In addition, seven workshops will be held on specific topics. So, in total the congress will offer more that 750 scientific presen- tations. We want to thank Thieme, in particular Dr. Kuhlmann, for accepting that the abstracts could be printed in Planta Medica and for the proper processing. It is a huge task to handle this high number of abstracts and I want to thank also the editorial team, in particular Prof. Franz Bucar and his assistant Mag. Marlene Monschein, for all their efforts. Also Dr. Wolfgang Schhly, Dr. Eva Wenzig and Dr. Karin Wlkart contributed a lot to edit the abstracts and helped to bring them into a form which could be accepted for Planta Medica. All colleagues who acted in the Scientific Committee as reviewers and who actively contributed to the high scientific stand of this abstract volume are also acknowledged. Prof. Dr. Rudolf Bauer Chairman of GrAz 2007 Planta Med 2007; 73: 797–1034 Georg Thieme Verlag KG Stuttgart · New York · ISSN 0032-0943 the Convention on Biodiversity can provide incentives for discovery Plenary lectures of exciting new medicines, while ensuring equitable sharing of be- nefits. PL 001 PL 003 Bioactive Natural Products: A journey of a Thai scientist Phytochemicals for bacterial resistance – strengths, Mahidol C weaknesses and opportunities Chulabhorn Research Institute, Vipavadee Rangsit Highway, Bangkok 10210, Gibbons S Thailand Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, University of London, 29 – 39 Brunswick Square, London, WC1N 1AX, U.K. Chemotherapy is one of the well-established approaches for the remedy of a large number of chronically debilitating or life-threate- There are enormous challenges facing the pharmaceutical industry ning diseases that urgently require improved or new medical treat- with regard to the burgeoning threat of bacterial multi-drug resis- ments. With new emerging diseases and increasing resistance to tance (MDR). The proliferation of strains of methicillin-resistant Abstracts existing drugs, there is a pressing need to discover and develop Staphylococcus aureus (MRSA), Clostridium difficile, intrinsically re- new innovative drugs with diminished side-effects to combat can- sistant Gram-negative bacteria such as Acinetobacter baumannii and cer cells, viruses and other threats. Research on natural products is extremely-drug resistant Mycobacterium tuberculosis (XDR-TB) [1] essential for the discovery of lead compounds because of the incre- are cause for considerable concern. Very few new antibacterials dible diversity of chemical structures that are produced by living are appearing largely because the markets are both specialist and animals, plants, micro-organisms and marine organisms. It is consi- small, or are for areas of the developing world where the population dered that because of the structural and biological diversity of their is unable to pay for expensive new antibiotics. Recent new cases of constituents, terrestrial plants offer a unique and renewable resour- XDR-TB in the US and Europe and reports of a global increase in ce for the discovery of potential new drugs and biological entities. In patients with strains of MDR-TB will focus attention on the need for this presentation, our current research on natural products from new agents to deal with these threats. Plants are a practically un- various
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