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Breakthrough How Ideas Exchanged in the Canteen Can Lead to Research Discoveries

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Breakthrough How Ideas Exchanged in the Canteen Can Lead to Research Discoveries News from the Medical Research Council network Summer 2013 100 years of life-changing discoveries The greatcoffee breakthrough How ideas exchanged in the canteen can lead to research discoveries. Discoveries of the century Well-known figures give us their thoughts on the biggest medical advances, past and future. Network can also be downloaded as a PDF at: www.mrc.ac.uk/network CONTENTS NEWS News COMMENT FROM A phenomenal legacy begins 3 A phenomenal John Informatics research centres launched across the UK 3 legacy begins Speedier access to brain tissue for research 5 Savill Universities and Science Minister David Willetts has officially opened the MRC-NIHR Phenome Centre CHIEF EXECUTIVE at Imperial College London, which will re-purpose some of the sophisticated technology from the Royal opening for new LMB building 5 The launch of four e-health London 2012 Olympics Anti-Doping Centre. informatics research centres (eHIRCs) and the UK informatics Unlike our genome, which collectively describes a person’s genetic material, the phenome describes all the other chemistry of our research network by the Science body. It is the product of how our genes and environment interact throughout development and life, and is analysed by linking our Minister in May (see opposite), chemical, metabolic and physiological features and responses. By measuring phenome patterns throughout life, researchers at the Latest discoveries marked part of a £90m total centre aim to identify the patterns which separate those who develop particular diseases from those who don’t. investment in so-called big data or Gout drug offers hope for heart disease patients 10 medical bioinformatics research– something we excel at here in The centre’s first three pilot studies are now underway. One study will carry out detailed analysis of samples and data taken from the UK. people at various altitudes on an expedition to Mount Everest. Oxygen levels decrease at higher altitudes, so the study will serve as a Ditching lab tests gives more children model for studying why some intensive care patients who have been starved of oxygen recover while others don’t survive. access to HIV therapy 10 The eHIRCs were established with £19m joint funding from 10 government and charity partners, in an initiative Another of the pilot studies will aim to pinpoint what makes Europeans of Indian Asian descent more prone to type 2 diabetes than co-ordinated by the MRC. Capitalising on the UK’s unique their native European counterparts – a risk that can’t be explained by differences in obesity, diet, physical inactivity or known Evolutionary glitch may be culprit behind glue ear 11 wealth of ‘cradle to grave’ NHS patient data, they’ll support genetic variants. research linking patient records and research data and build capacity and skills in this burgeoning field. www1.imperial.ac.uk/phenomecentre Genetics study sheds light on heart rhythm disorders 11 We’re about to invest another £20m into the eHIRCs to improve access to patient records for research, extend partnerships between the NHS, industry and academia and build the necessary digital infrastructure for this research. Funding Informatics research centres launched across the UK And we’ve recently put a further £50m into a call in medical The drive to defeat dementia 14 bioinformatics linking NHS patient records research and MRC funded cohorts and resources to the rich human Four e-health informatics research to have such a rich source of information on the data generated from imaging studies and high-throughput centres (eHIRCs) and a UK informatics health of its people from cradle to grave. Research £47 million Biomedical Catalyst support for technologies such as genomics. using NHS patient records will help develop more research network were officially effective treatments, improvements in health SME-academic projects 15 An important part of these investments is building a strong launched by Universities and Science services delivery and drug safety, and advances in cadre of scientists with the skills to analyse, interpret and Minister David Willetts in May, understanding the causes of diseases on a scale which was not previously possible. link these datasets to ensure we have the talent to take this following investment of £19m from 10 important research forward in years to come. Alongside this, we’re continuing to develop a robust regulatory and ethical government and charity funding The eHIRCs are linked with 15 UK universities, Features three MRC units and include several major framework to allow scientists to access and share the data organisations coordinated by the MRC. whilst carefully protecting patient information. pharmaceutical and technology company The great coffee breakthrough 6 partners. They will carry out research linking The UK has a reputation as a world-leader in this field. We In his speech Mr Willetts said that the launch e-health records with other forms of research and Discoveries of the century 8 want to help sustain and enhance that reputation, so that “marked another step forward in our commitment routinely collected data. we stay ahead of the game and deliver new benefits for to medical research”. science, health and the economy. I’m confident these The network and eHIRCs will offer interdisciplinary My work space: Dr Edmund Kunji, investments will help us achieve that goal. The aim of the eHIRCs, based in London, career development and training opportunities MRC Mitochondrial Biology Unit 12 Manchester, Swansea and Dundee, is to capitalise working with biomedical, social and computer on the wealth of patient data in the NHS for sciences across the UK and provide a gateway Sir John Savill for collaboration with industry, the NHS and MRC Chief Executive research. The UK is the only country in the world the public. MRCNetwork | 3 NEWS An open Strictly Science invitation Calling all MRC-funded “Amazing” and “Excellent - especially the turnip juice and eye pong,” students and fellows! From 20 – 26 June, MRC units and centres across the UK were among the reactions of visitors to a free public exhibition on the Tell us why your will throw open their doors to the public to give them a past, present and future of medical research hosted by Imperial College research matters. taste of some of the awe-inspiring science that goes on London in April. in our establishments. Our Centenary Open Week will First prize: £1,500 and kick off with a festival of science held at the Science Strictly Science: keeping one step ahead – masterminded by the MRC promotion in Times Museum (see below). Find out about open days near Clinical Sciences Centre to mark the MRC’s Centenary – was visited by Higher Education you on our Centenary website at: more than 5,000 people. Visitors were treated to lively debates, Speedier access to brain tissue for research www.centenary.mrc.ac.uk/open_days re-enactments of 100-year old experiments and got to try out • Write an 800-word article for a non-scientific audience interactive digital tools used by neuroscientists such as eye-trackers A new online database will save brain researchers time in tracking describing your research and explaining why it matters ace and balance boards. down human tissue samples for their work. • Shortlisted entrantstypef invited to a writing masterclass and an awards MRC Centenary festival celebrates a healthy life ceremony at the Science Museum, London on 25 September In the ‘tomorrow lab’, younger visitors made short videos on their Researchers can use the database to browse through details of all • For a chance to win £500, why not also take up our 100-word To share our 100th birthday with the widest possible audience, we’re visions of the future of medical research, forming part of a growing tissue samples held by the 10 brain banks which form the UK Brain Centenary Challenge? hooking up with London’s Science Museum on 15 and 16 June to archive of ‘digital futures’ which can be found on Youtube. You can add Banks Network. create a weekend festival of MRC science. your own ideas at www.youtube.com/strictlyscience and find out more Competition closes 23:59 on Sunday 23 June 2013. about the exhibition at www.strictlyscience.mrc.ac.uk Funded by the MRC, NHS and five brain charities, the network Activities and talks will bring scientists and the public together to holds healthy and diseased tissue from over 7,000 brains. For more information and the entry form: discuss MRC research and how it builds on our research legacy from Researchers will also be able to order samples through the www.mrc.ac.uk/Sciencesociety/Awards the past 100 years. Nine London-based MRC research teams will be database, and because all the banks now have ethics approval as [email protected] taking part to create an exciting hands-on exhibition called Life. research tissue banks, tissue can be provided to researchers twitter.com/mrccomms • #maxperutzaward • #100MRC without the need for them to apply for ethics approval first. Museum visitors will be able to enter the MRC festival as a character and journey through the years talking to our scientists and finding Find out more at: www.mrc.ac.uk/Ourresearch/Resourceservices/ out about their amazing research on the brain, viruses and lots UKBrainBanksnetwork/database more. Characters will be able to make ‘life choices’ as they progress through the exhibition, to see how their actions can influence their Royal opening for new LMB building health and longevity. Her Majesty the Queen officially opened the new MRC Laboratory of Activities will include a giant nose that children can crawl inside Prizes and honours Molecular Biology building in Cambridge on 23 May. A decade in the to discover the allergens that accumulate there, target games to planning, the X-shaped glass and steel edifice houses 600 scientists, show the how antibiotics work and a live fruit fly experiment to Our Centenary year has already seen several MRC scientists receive providing the 21st century facilities needed to allow this prestigious demonstrate how our brains and bodies are wired together.
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