Institute of Medicine (IOM)
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[email protected] (609) 258-5981 Jonikaslab.Princeton.Edu Updated 3/10/2021
Martin Casimir Jonikas, Ph.D. Assistant Professor, Department of Molecular Biology Princeton University, Princeton, NJ 08544 [email protected] (609) 258-5981 jonikaslab.princeton.edu updated 3/10/2021 VISION My group seeks to advance the basic understanding of cell biology. We study the pyrenoid, a fascinating phase-separated organelle that enhances CO2 capture in nearly all eukaryotic algae. Understanding the pyrenoid is important for three reasons: (1) the pyrenoid plays a central role in our planet’s carbon cycle, (2) the pyrenoid embodies fundamental questions in organelle biogenesis, and (3) engineering a pyrenoid into land plants could dramatically increase crop yields. To accelerate progress, we are developing community resources for the unicellular green alga Chlamydomonas reinhardtii as a model system for photosynthetic organisms. My group also seeks to nurture and train future world-leading scientists. EDUCATION 2004 B.S., Aerospace Engineering, Massachusetts Institute of Technology 2009 Ph.D., Biochemistry and Molecular Biology, University of California, San Francisco. Research advisors: Dr. Jonathan Weissman and Dr. Peter Walter PROFESSIONAL POSITIONS 2010-2016 Young Investigator (faculty position equivalent to Assistant Professor), Department of Plant Biology, Carnegie Institution for Science, Stanford, CA 2011-2016 Assistant Professor by courtesy, Department of Biology, Stanford University, Stanford, CA 2016-present Assistant Professor, Department of Molecular Biology, Princeton University, Princeton, NJ 2019-present Affiliated Faculty, Princeton Quantitative and Computational Biology Program AWARDS AND HONORS 2002 1st place, MIT 2.007 Robotics Competition 2005 National Science Foundation Graduate Research Fellowship 2009 Harvard Bauer Fellowship (declined) 2010 Air Force Office of Scientific Research Young Investigator Award 2015 National Institutes of Health Director's New Innovator Award 2016 HHMI-Simons Faculty Scholar Award 2020 Vilcek Prize for Creative Promise in Biomedical Science Martin Casimir Jonikas, Ph.D. -
Plant Molecular Farming: a Viable Platform for Recombinant Biopharmaceutical Production
plants Review Plant Molecular Farming: A Viable Platform for Recombinant Biopharmaceutical Production Balamurugan Shanmugaraj 1,2, Christine Joy I. Bulaon 2 and Waranyoo Phoolcharoen 1,2,* 1 Research Unit for Plant-Produced Pharmaceuticals, Chulalongkorn University, Bangkok 10330, Thailand; [email protected] 2 Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences Chulalongkorn University, Bangkok 10330, Thailand; [email protected] * Correspondence: [email protected]; Tel.: +66-2-218-8359; Fax: +66-2-218-8357 Received: 1 May 2020; Accepted: 30 June 2020; Published: 4 July 2020 Abstract: The demand for recombinant proteins in terms of quality, quantity, and diversity is increasing steadily, which is attracting global attention for the development of new recombinant protein production technologies and the engineering of conventional established expression systems based on bacteria or mammalian cell cultures. Since the advancements of plant genetic engineering in the 1980s, plants have been used for the production of economically valuable, biologically active non-native proteins or biopharmaceuticals, the concept termed as plant molecular farming (PMF). PMF is considered as a cost-effective technology that has grown and advanced tremendously over the past two decades. The development and improvement of the transient expression system has significantly reduced the protein production timeline and greatly improved the protein yield in plants. The major factors that drive the plant-based platform towards potential competitors for the conventional expression system are cost-effectiveness, scalability, flexibility, versatility, and robustness of the system. Many biopharmaceuticals including recombinant vaccine antigens, monoclonal antibodies, and other commercially viable proteins are produced in plants, some of which are in the pre-clinical and clinical pipeline. -
Strategies and Experiences to Improve Research Uptake: the Royal Society and UK Science Funding
Strategies and experiences to improve research uptake: The Royal Society and UK science funding Wider context Credit crunch UK Government Deficit New government Spending cuts The Royal Society Advisory Group Sir Martin Taylor FRS (Chair), Former Vice-President and Physical Secretary, The Royal Society Professor Glynis Breakwell, Vice-Chancellor, University of Bath Professor Ann Dowling DBE CBE FRS FREng, Professor of Engineering, University of Cambridge Sir Martin Evans FRS, Director, Cardiff School of Biosciences Sir Richard Friend FRS. Professor of Physics, University of Cambridge Professor Rachel Griffith FBA, Deputy Research Director, Institute for Fiscal Studies Professor Wendy Hall DBE FREng FRS, Professor of Computer Science, University of Southampton Dr Emily Holmes, Department of Psychiatry, University of Oxford Professor Richard Jones FRS, Professor of Physics, Sheffield University Professor Ben Martin, Science and Technology Policy Research Unit (SPRU) Paul Mountford, President, Emerging Markets, Cisco Professor Helga Nowotny, Vice-President, European Research Council Sir Paul Nurse FRS, President, Rockefeller University, New York City Dr David Roblin, Vice-President Global R&D, Pfizer Lord Sainsbury of Turville FRS, Gatsby Charitable Foundation Lord Waldegrave of North Hill, Provost, Eton College Sir Mark Walport, Director of the Wellcome Trust Sir Alan Wilson FRS FBA, Chairman, Arts and Humanities Research Council 7 Engagement across the political spectrum Lord Sainsbury of Turville FRS, Lord Waldegrave of North Hill, Conservative Labour Public R&D expenditure, 1970-2007 The UK punches above its weight The Cambridge phenomenon People in and outside science Global competition Average annual growth in R&D budgets, 1997-2007 ‘By the end of 2020…China will join the ranks of the world’s most innovative countries’ President Hu Jintao, Jan 2006 Investing in the downturn 0.60% 0.50% 0.40% Green technology R&D 0.30% GDP 0.20% 0.10% 0.00% Finland Norway Canada Portugal Germany Sweden USA Recommendations 1. -
Biochemistry, Genetics, Molecular and Cell Biology) Hit the Newspaper Headlines on a Weekly Basis
The Tenovus-Scotland Symposia and Medal Lectures Today medical advances as a result of discoveries in the Life Sciences (Biochemistry, Genetics, Molecular and Cell Biology) hit the newspaper headlines on a weekly basis. This was not the case at the time of the first Tenovus-Scotland Symposium nearly 35 years ago. Since the discovery of the structure of DNA twenty years earlier, great advances had been made in understanding, at the level of molecules, how genes work in the cell. From study of simple bacteria and viruses, it was known that the information for making all the different proteins in the cell was encoded in the sequence of nucleotides, the individual chemical units of DNA, but study of higher organisms seemed impossibly complex. The chromosomes in each human cell have about 23,000 genes in their DNA that contains a total of about three thousand million nucleotides - how would it be possible to study these genes individually? Three staff from the Biochemistry Department and the Beatson Institute planned a two day meeting at Glasgow University in 1974 to bring together scientists to discuss and learn about the new discoveries that were beginning to provide answers to that fundamental question. Sir Charles Illingworth, who had recently founded Tenovus- Scotland, saw the importance of these studies and their potential future application in medicine and agreed a grant towards the cost of the meeting, which we called the Tenovus-Scotland Symposium although the First Meeting was also jointly sponsored by the Nucleotide Group of the -
US EPA, Pesticide Product Label, WIDESTRIKE 3 INSECT
UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON, D.C. 20460 OFFICE OF CHEMICAL SAFETY AND POLLUTION PREVENTION October 18, 2016 Stephanie L. Burton US Regulatory Manager Dow AgroSciences LLC 9330 Zionsville Road Indianapolis, IN 46268-1054 Subject: PRIA (Pesticide Registration Improvement Act) Amendment – to update the terms of registration related to gene flow and revise the product label. Product Name: WideStrike® 3 Insect Resistant Cotton EPA Registration Number: 68467-19 Application Date: June 23, 2016 OPP Decision Number: 518794 Dear Ms. Burton: The amendment referred to above, submitted in connection with registration under the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA), as amended, are acceptable provided you comply with the revised terms of registration as set forth below: 1. Submit/cite all data required for registration of your product under FIFRA § 3(c)(5) when the Agency requires all registrants of similar products to submit such data. 2. Gene Flow The following information regarding commercial production must be included in the grower guide for WideStrike® 3 Insect Resistant Cotton: a) No planting of WideStrike® 3 Insect Resistant Cotton is permitted south of Route 60 (near Tampa) in Florida. b) Commercial culture of WideStrike® 3 Insect Resistant Cotton is prohibited in Hawaii, Puerto Rico, and the US Virgin Islands. The following information regarding test plots and seed production must appear in contracts or on bags of WideStrike® 3 Insect Resistant Cotton intended for the following purposes: Page 2 of 10 EPA Reg. No. 68467-19 OPP Decision No. 518794 a) Test plots or breeding nurseries, regardless of the plot size, established in Hawaii must not be planted within 3 miles of Gossypium tomentosum. -
Mothers in Science
The aim of this book is to illustrate, graphically, that it is perfectly possible to combine a successful and fulfilling career in research science with motherhood, and that there are no rules about how to do this. On each page you will find a timeline showing on one side, the career path of a research group leader in academic science, and on the other side, important events in her family life. Each contributor has also provided a brief text about their research and about how they have combined their career and family commitments. This project was funded by a Rosalind Franklin Award from the Royal Society 1 Foreword It is well known that women are under-represented in careers in These rules are part of a much wider mythology among scientists of science. In academia, considerable attention has been focused on the both genders at the PhD and post-doctoral stages in their careers. paucity of women at lecturer level, and the even more lamentable The myths bubble up from the combination of two aspects of the state of affairs at more senior levels. The academic career path has academic science environment. First, a quick look at the numbers a long apprenticeship. Typically there is an undergraduate degree, immediately shows that there are far fewer lectureship positions followed by a PhD, then some post-doctoral research contracts and than qualified candidates to fill them. Second, the mentors of early research fellowships, and then finally a more stable lectureship or career researchers are academic scientists who have successfully permanent research leader position, with promotion on up the made the transition to lectureships and beyond. -
BSCB Newsletter 2017D
2017 BSCB Newsletter BRITISH SOCIETY FOR CELL BIOLOGY Meet the new BSCB President Royal Opening of the Crick Meeting reports 2017 CONTENTS BSCB Newsletter News 2 Book reviews 7 Features 8 Meeting Reports 24 Summer students 30 Society Business 33 Editorial Welcome to the 2017 BSCB newsletter. After several meeting hosted several well received events for our Front cover: years of excellent service, Kate Nobes has stepped PhD and Postdoc members, which we discuss on The head of a Drosophila pupa. The developing down and handed the reins over to me. I’ve enjoyed page 5. Our PhD and Postdoc reps are working hard compound eye (green) is putting together this years’ newsletter. It’s been great to make the event bigger and better for next year! The composed of several hundred simple units called ommatidia to hear what our members have been up to, and I social events were well attended including the now arranged in an extremely hope you will enjoy reading it. infamous annual “Pub Quiz” and disco after the regular array. The giant conference dinner. Members will be relieved to know polyploidy cells of the fat body (red), the fly equivalent of the The 2016 BSCB/DB spring meeting, organised by our we aren’t including any photos from that here. mammalian liver and adipose committee members Buzz Baum (UCL), Silke tissue, occupy a big area of the Robatzek and Steve Royle, had a particular focus on In this issue, we highlight the great work the BSCB head. Cells and Tissue Architecture, Growth & Cell Division, has been doing to engage young scientists. -
The Nobel Prize Sweden.Se
Facts about Sweden: The Nobel Prize sweden.se The Nobel Prize – the award that captures the world’s attention The Nobel Prize is considered the most prestigious award in the world. Prize- winning discoveries include X-rays, radioactivity and penicillin. Peace Laureates include Nelson Mandela and the 14th Dalai Lama. Nobel Laureates in Literature, including Gabriel García Márquez and Doris Lessing, have thrilled readers with works such as 'One Hundred Years of Solitude' and 'The Grass is Singing'. Every year in early October, the world turns Nobel Day is 10 December. For the prize its gaze towards Sweden and Norway as the winners, it is the crowning point of a week Nobel Laureates are announced in Stockholm of speeches, conferences and receptions. and Oslo. Millions of people visit the website At the Nobel Prize Award Ceremony in of the Nobel Foundation during this time. Stockholm on that day, the Laureates in The Nobel Prize has been awarded to Physics, Chemistry, Physiology or Medicine, people and organisations every year since and Literature receive a medal from the 1901 (with a few exceptions such as during King of Sweden, as well as a diploma and The Nobel Banquet is World War II) for achievements in physics, a cash award. The ceremony is followed a magnificent party held chemistry, physiology or medicine, literature by a gala banquet. The Nobel Peace Prize at Stockholm City Hall. and peace. is awarded in Oslo the same day. Photo: Henrik Montgomery/TT Henrik Photo: Facts about Sweden: The Nobel Prize sweden.se Prize in Economic Sciences prize ceremonies. -
Pomona College Magazine Fall/Winter 2020: the New (Ab
INSIDE:THE NEW COLLEGE MAGAZINE (AB)NORMAL • The Economy • Childcare • City Life • Dating • Education • Movies • Elections Fall-Winter 2020 • Etiquette • Food • Housing •Religion • Sports • Tourism • Transportation • Work & more Nobel Laureate Jennifer Doudna ’85 HOMEPAGE Together in Cyberspace With the College closed for the fall semester and all instruction temporarily online, Pomona faculty have relied on a range of technologies to teach their classes and build community among their students. At top left, Chemistry Professor Jane Liu conducts a Zoom class in Biochemistry from her office in Seaver North. At bottom left, Theatre Professor Giovanni Molina Ortega accompanies students in his Musical Theatre class from a piano in Seaver Theatre. At far right, German Professor Hans Rindesbacher puts a group of beginning German students through their paces from his office in Mason Hall. —Photos by Jeff Hing STRAY THOUGHTS COLLEGE MAGAZINE Pomona Jennifer Doudna ’85 FALL/WINTER 2020 • VOLUME 56, NO. 3 2020 Nobel Prize in Chemistry The New Abnormal EDITOR/DESIGNER Mark Wood ([email protected]) e’re shaped by the crises of our times—especially those that happen when ASSISTANT EDITOR The Prize Wwe’re young. Looking back on my parents’ lives with the relative wisdom of Robyn Norwood ([email protected]) Jennifer Doudna ’85 shares the 2020 age, I can see the currents that carried them, turning them into the people I knew. Nobel Prize in Chemistry for her work with They were both children of the Great Depression, and the marks of that experi- BOOK EDITOR the CRISPR-Cas9 molecular scissors. Sneha Abraham ([email protected]) ence were stamped into their psyches in ways that seem obvious to me now. -
Pan Macmillan AUTUMN CATALOGUE 2021 PUBLICITY CONTACTS
Pan Macmillan AUTUMN CATALOGUE 2021 PUBLICITY CONTACTS General enquiries [email protected] Alice Dewing FREELANCE [email protected] Anna Pallai Amy Canavan [email protected] [email protected] Caitlin Allen Camilla Elworthy [email protected] [email protected] Elinor Fewster Emma Bravo [email protected] [email protected] Emma Draude Gabriela Quattromini [email protected] [email protected] Emma Harrow Grace Harrison [email protected] [email protected] Jacqui Graham Hannah Corbett [email protected] [email protected] Jamie-Lee Nardone Hope Ndaba [email protected] [email protected] Laura Sherlock Jess Duffy [email protected] [email protected] Ruth Cairns Kate Green [email protected] [email protected] Philippa McEwan [email protected] Rosie Wilson [email protected] Siobhan Slattery [email protected] CONTENTS MACMILLAN PAN MANTLE TOR PICADOR MACMILLAN COLLECTOR’S LIBRARY BLUEBIRD ONE BOAT MACMILLAN Nine Lives Danielle Steel Nine Lives is a powerful love story by the world’s favourite storyteller, Danielle Steel. Nine Lives is a thought-provoking story of lost love and new beginnings, by the number one bestseller Danielle Steel. After a carefree childhood, Maggie Kelly came of age in the shadow of grief. Her father, a pilot, died when she was nine. Maggie saw her mother struggle to put their lives back together. As the family moved from one city to the next, her mother warned her about daredevil men and to avoid risk at all cost. Following her mother’s advice, and forgoing the magic of first love with a high-school boyfriend who she thought too wild, Maggie married a good, dependable man. -
Curriculum Vitae Prof. Dr. Geoffrey L. Smith
Curriculum Vitae Prof. Dr. Geoffrey L. Smith Name: Geoffrey L. Smith Born: 23 July 1955 Main areas of research: Microbiology, virology, immunology, vaccinia virus, vaccines Geoffrey L. Smith is a British microbiologist and virologist specialising in the area of poxviruses. His research examines the interaction of poxviruses with the infected host cell and the immune system, concentrating especially on the vaccinia virus that was the vaccine used to eradicate smallpox. His research has enabled new vaccination concepts to be developed and provided important insights into how viruses evade the host innate immune response and cause disease. Academic and Professional Career since 2011 Chair of the Pathology Department, University of Cambridge, UK and Principal Research Fellow, Wellcome Trust 2000 ‐ 2011 Director, Department of Virology, Imperial College London, UK 1989 ‐ 2000 Reader then Professor, University of Oxford, UK 1985 ‐ 1989 Lecturer in Virology, University of Cambridge, UK 1981 ‐ 1984 Postdoctoral Fellow, National Institutes of Health, Bethesda, USA 1981 PhD, National Institute for Medical Research, Mill Hill, London, UK Functions in Scientific Societies and Committees since 2015 Chair of the scientific council, Friedrich Löffler Institute 2012 ‐ 2016 Member, Biomedical Panel of the University Research Grant Committee, Hong Kong 2011 ‐ 2014 President, International Union of Microbiological Societies 2009 ‐ 2012 Chair, Royal Society Committee for Scientific Aspects of International Security Nationale Akademie der Wissenschaften Leopoldina -
Therapeutic Cloning Gives Silenced Genes a Second Voice
NEWS p1007 Tricky Fix: p1009 Bohemian p1010 Better than A vaccine for cocaine brain: Neuroscientist Prozac: What’s next in addiction poses John Hardy bucks antidepressant drug ethical dilemmas. the trends. development? Therapeutic cloning gives silenced genes a second voice As controversy continues on therapeutic experiments in Xenopus embryos, is the removal silencing may not be permanent.” cloning to create human embryos, applying the of methyl groups from specific regions of DNA. Jaenisch and his colleagues have also shown technique—also known as somatic cell nuclear This may be a necessary step in the epigenetic that nuclei from a skin cancer cell can be repro- transfer—in animals is generating important reprogramming of the nucleus, the researchers grammed to direct normal development of a insights into disease development. suggest in the October Nature Cell Biology. mouse embryo—meaning that removal of the Some scientists are using the approach to As cells differentiate, they accrue many epigenetic alterations is enough to restore cells study epigenetic alterations—chromosomal other types of epigenetic alterations, such as to normal (Genes Dev.18,1875–1885; 2004).An modifications that do not alter the DNA the addition of phosphates or removal of earlier study reported similar results with brain sequence—which can cause cancer. “A acetyl groups from histones, or chromosomal tumor cells (Cancer Res. 63, 2733–2736; 2003). principal question in cancer research is what proteins, and trigger changes in chromatin Based on such findings, pharmaceutical part of the cancer cell phenotype comes from structure. Defects in these processes have been companies are racing to develop and test ‘epige- genetic defects and what part is epigenetic,”says linked to cancer and other diseases.