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BSCB Newsletter 2017D
2017 BSCB Newsletter BRITISH SOCIETY FOR CELL BIOLOGY Meet the new BSCB President Royal Opening of the Crick Meeting reports 2017 CONTENTS BSCB Newsletter News 2 Book reviews 7 Features 8 Meeting Reports 24 Summer students 30 Society Business 33 Editorial Welcome to the 2017 BSCB newsletter. After several meeting hosted several well received events for our Front cover: years of excellent service, Kate Nobes has stepped PhD and Postdoc members, which we discuss on The head of a Drosophila pupa. The developing down and handed the reins over to me. I’ve enjoyed page 5. Our PhD and Postdoc reps are working hard compound eye (green) is putting together this years’ newsletter. It’s been great to make the event bigger and better for next year! The composed of several hundred simple units called ommatidia to hear what our members have been up to, and I social events were well attended including the now arranged in an extremely hope you will enjoy reading it. infamous annual “Pub Quiz” and disco after the regular array. The giant conference dinner. Members will be relieved to know polyploidy cells of the fat body (red), the fly equivalent of the The 2016 BSCB/DB spring meeting, organised by our we aren’t including any photos from that here. mammalian liver and adipose committee members Buzz Baum (UCL), Silke tissue, occupy a big area of the Robatzek and Steve Royle, had a particular focus on In this issue, we highlight the great work the BSCB head. Cells and Tissue Architecture, Growth & Cell Division, has been doing to engage young scientists. -
DNA Repair Systems Guardians of the Genome
GENERAL ARTICLE DNA Repair Systems Guardians of the Genome D N Rao and Yedu Prasad The 2015 Nobel Prize in Chemistry was awarded jointly to Tomas Lindahl, Paul Modrich and Aziz Sancar to honour their accomplishments in the field of DNA repair. Ever since the discovery of DNA structure and their importance in the storage of genetic information, questions about their stability became pertinent. A molecule which is crucial for the de- velopment and propagation of an organism must be closely D N Rao is a professor at the monitored so that the genetic information is not corrupted. Department of Biochemistry, Thanks to the pioneering research work of Lindahl, Sancar, Indian Institute of Science, Modrich and their colleagues, we now have an holistic aware- Bengaluru. His research ness of how DNA damage occurs and how the damage is rec- work primarily focuses on DNA interacting proteins in tified in bacteria as well as in higher organisms including hu- prokaryotes. This includes man beings. A comprehensive understanding of DNA repair restriction-modification has proven crucial in the fight against cancer and other debil- systems, DNA repair proteins itating diseases. from pathogenic bacteria and and proteins involved in The genetic information that guides the development, metabolism horizontal gene transfer and and reproduction of all living organisms and many viruses resides DNA recombination. in the DNA. This biological information is stored in the DNA Yedu Prasad is a graduate molecule as combinations of sequences that are formed by purine student working on his PhD and pyrimidine bases attached to the deoxyribose sugar (Figure under the guidance of D N 1). -
Dundeeuniversi of Dundee Undergraduate Prospectus 2019
This is Dundee Universi of Dundee Undergraduate Prospectus 2019 One of the World’s Top 200 Universities Times Higher Education World Universi Rankings 2018 This is Dundee Come and visit us Undergraduate open days 2018 and 2019 Monday 27 August 2018 Saturday 22 September 2018 Monday 26 August 2019 Saturday 21 September 2019 Talk to staff and current students, tour our fantastic campus and see what the University of Dundee can offer you! Booking is essential visit uod.ac.uk/opendays-ug email [email protected] “It was an open day that made me choose Dundee. The universities all look great and glitzy on the prospectus but nothing compares to having a visit and feeling the vibe for yourself.” Find out more about why MA Economics and Spanish student Stuart McClelland loved our open day at uod.ac.uk/open-days-blog Contents Contents 8 This is your university 10 This is your campus 12 Clubs and societies 14 Dundee University Students’ Association 16 Sports 18 Supporting you 20 Amazing things to do for free (or cheap!) in Dundee by our students 22 Best places to eat in Dundee – a students’ view 24 You’ll love Dundee 26 Map of Dundee 28 This is the UK’s ‘coolest little city’ (GQ Magazine) 30 Going out 32 Out and about 34 This is your home 38 This is your future 40 These are your opportunities 42 This is your course 44 Research 46 Course Guide 48 Making your application 50 Our degrees 52 Our MA honours degree 54 Our Art & design degrees 56 Our life sciences degrees 58 Studying languages 59 The professions at Dundee 60 Part-time study and lifelong learning 61 Dundee is international 158 Advice and information 160 A welcoming community 161 Money matters 162 Exchange programmes 164 Your services 165 Where we are 166 Index 6 7 Make your Make This is your university This is your Summer Graduation in the City Square Summer Graduation “Studying changes you. -
N E W S I N B R I
N E W S I N B R I E F NOBEL PRIZE IN MEDICINE The Nobel Prize in Chemistry 2015 was awarded jointly to Tomas Lindahl, Paul Modrich and Aziz Sancar for elucidating At the height of the Vietnamese war, the common enemy of three different mechanisms by which errors occur in our DNA soldiers on either side of the battle lines was chloroquine- and the various mechanisms of DNA repair. In the 1970’s, resistant malaria. In 1964, the North Vietnamese Government Lindahl discovered that DNA undergoes regular decay and approached the Chinese leader Mao Tse Tung to find a damage. For example, cytosine loses an amino group to become solution to this deadly scourge. Mao immediately established uracil resulting in a mutation. Subsequently, he discovered an a military mission Project 523 with a main aim to discover a enzyme system called uracil-DNA glycosylase which corrects drug for resistant malaria. Youyou Tu was a phytochemist who this error. This process was called base excision repair. Aziz was in charge of the project. She and her team combed through Sancar discovered and cloned the gene for an enzyme called hundreds of old Chinese traditional medicine texts. Around photolyase which is critical in correcting DNA mutations caused 2000 chemicals extracted from various plants were evaluated. by high doses of UV exposure. He further went on to identify the Finally, they zeroed on to an extract of Artemesia annua L. exact chemical processes involved in this nucleotide excision also called Quinhao which was found to have excellent repair. Paul Modrich discovered the mechanism by which DNA antimalarial efficacy in a mouse model. -
Curriculum Vitae Prof. Dr. Geoffrey L. Smith
Curriculum Vitae Prof. Dr. Geoffrey L. Smith Name: Geoffrey L. Smith Born: 23 July 1955 Main areas of research: Microbiology, virology, immunology, vaccinia virus, vaccines Geoffrey L. Smith is a British microbiologist and virologist specialising in the area of poxviruses. His research examines the interaction of poxviruses with the infected host cell and the immune system, concentrating especially on the vaccinia virus that was the vaccine used to eradicate smallpox. His research has enabled new vaccination concepts to be developed and provided important insights into how viruses evade the host innate immune response and cause disease. Academic and Professional Career since 2011 Chair of the Pathology Department, University of Cambridge, UK and Principal Research Fellow, Wellcome Trust 2000 ‐ 2011 Director, Department of Virology, Imperial College London, UK 1989 ‐ 2000 Reader then Professor, University of Oxford, UK 1985 ‐ 1989 Lecturer in Virology, University of Cambridge, UK 1981 ‐ 1984 Postdoctoral Fellow, National Institutes of Health, Bethesda, USA 1981 PhD, National Institute for Medical Research, Mill Hill, London, UK Functions in Scientific Societies and Committees since 2015 Chair of the scientific council, Friedrich Löffler Institute 2012 ‐ 2016 Member, Biomedical Panel of the University Research Grant Committee, Hong Kong 2011 ‐ 2014 President, International Union of Microbiological Societies 2009 ‐ 2012 Chair, Royal Society Committee for Scientific Aspects of International Security Nationale Akademie der Wissenschaften Leopoldina -
Aziz SANCAR WINS Nobel Prize
Advancing SCIENCE Aziz Sancar, 2015 Nobel laureate in chemistry extremely proud that he is a member of TWAS, and we offer him heartfelt congratulations.” Sharing the prize with Sancar are two other chemists who have made pioneering discoveries in gene repair: Swedish native Tomas Lindahl of the Francis Crick Institute and Clare Hall Laboratory in Hertfordshire, UK, and American Paul Modrich of the Howard Hughes Medical Institute and Duke University School of Medicine in North Carolina. “Systematic work” by the three researchers “has made a decisive contribution to the understanding of how the living cell functions, as well as providing knowledge about the AZIZ SANCAR molecular causes of several hereditary diseases and about mechanisms behind both cancer development and WINS NOBEL PRIZE aging,” the Royal Swedish Academy of Sciences said in announcing the prizes. by Edward W. Lempinen Sancar, 69, was born in Savur, a small town in southeastern Turkey. The Turkish-born DNA to remove the damaged genetic He was the seventh of eight children. code. His initial discoveries at Yale “My parents were both illiterate,” he scientist, elected to TWAS University in the United States focused said in a 2005 profile published in the in 1994, shares the 2015 on E. coli bacteria; more recently, at Proceedings of the National Academy the University of North Carolina in the of Sciences (USA), “but they valued the Nobel Prize in chemistry United States, he detailed the workings importance of education and did their of this DNA repair in humans. best to ensure that all of their children for research into DNA Sancar is the first native of Turkey to would receive some education.” repair. -
Nichola Hall University of Abertay Dundee Doctor of Philosophy
The influence of zinc on the physiology of industrial strains o f Saccharomyces cerevisiae Nichola Hall A thesis submitted in partial fulfilment of the requirements of the University of Abertay Dundee for the degree of Doctor of Philosophy November 2001 I certify that this is the true and accurate version of the thesis approved by the examiners. Signed Date. Director of Studies Abstract The yeast, Saccharomyces cerevisiae requires certain elements for the growth and development of healthy cultures. The divalent cation, zinc is of paramount importance to this yeast, as zinc is a structurally and functionally essential metal that cannot be replaced by any other element. Zinc accumulation by S. cerevisiae is a biphasic response, consisting of a rapid metabolism independent and a metabolism dependent phase. Metabolism-independent metal ion accumulation is a physical process, whereby the ions are associated with the cell wall. This stage of uptake is often referred to as biosorption and zinc uptake is influenced by temperature, pH, biomass concentration and the presence of competing ions. The second phase of zinc uptake (metabolism-dependent metal ion accumulation) concerns the intracellular accumulation of the ions. This biological accumulation, often abbreviated to bioaccumulation, is slower than biosorption as the zinc ions are transported into the cell, via the plasma membrane by the energy consuming process, active transport. The presence and type of metabolisable energy source, metabolic inhibitors, as well as the factors that affect biosorption also affect bioaccumulation. The genetics governing zinc accumulation by S. cerevisiae has recently been unravelled (Zhao and Eide, 1996a & b). Research has shown that a high (ZRT1) and a low (ZRT2) affinity transporter proteins exists, which act in zinc limiting and zinc replete conditions, respectively. -
Silver Squelchers Twenty One & Their Interesting Associates
Silver Squelchers Twenty One & Their Interesting Associates Megabankers in The Society “He spoke openly against the Society” (Line from “The Rifleman,” March 3, 1963) Take 32 seconds to hear what should be The Pilgrims theme music! Presented July-August 2015 by Charles Savoie Megabankers are one of the hardest groups in The Pilgrims Society on which to document membership. However past patterns, seen in lists from 1980 on back to 1914 and the charter members, indicate that if those patterns are followed, and there’s no cause why they shouldn’t be---we may expect, if we have an actual updated roster for both branches, to find members in top management and the boards of directors of banks including---Wells Fargo (263,900 employees); Citigroup (243,000 employees); JPM Chase (265,359 employees); Bank of America (233,000 employees); Bank of New York Mellon (50,300 employees, manages $28 trillion); more Barclays bankers (132,300 employees); more HSBC bankers (80 countries and over 50 million customers); Royal Bank of Scotland (33 million customers); Lloyd’s Banking Group (45,856 employees); Standard Chartered Bank (70 countries and 87,000 employees); Bank of Montreal (46,778 employees); Toronto Dominion Bank (79,000 employees); Royal Bank of Canada (73,500 employees); CIBC (Canadian Imperial Bank of Commerce, 44,424 employees); Scotia Bank (Bank of Nova Scotia, 87,000 employees); National Bank of Canada (20,000 employees); Northern Trust (14,100 employees); PNC Bank (2,700 branches and 52,000 employees); Capital One Bank (41,100 employees); Australia & New Zealand Banking Group (48,239 employees); Commonwealth Bank of Australia (44,329 employees); Western Pacific Banking Corporation of Australia (36,000 employees); and others including Swiss banks. -
Biological Sciences Title of Case Stud
Impact case study (REF3b) Institution: University of Dundee Unit of Assessment: 5: Biological Sciences Title of case study: Creation of the spin out company Dundee Cell Products (DCP) and impact on commercialisation of life sciences technology and reagents from the University of Dundee. 1. Summary of the impact (indicative maximum 100 words) As sophisticated proteomics methodologies are increasingly embraced by both academics and industry across the globe, growth in this area is set to explode. The University of Dundee has a leadership position in quantitative proteomics technology, through the expertise of Professor Angus Lamond. Dundee Cell Products Ltd is a University of Dundee spin-out company that was created to commercialise life sciences technology and reagents, and to exploit technology and expertise in proteomics developed at the College of Life Sciences. As of 2013, DCP offers >5,000 research products and six contract research services, centred around quantitative proteomics. 2. Underpinning research (indicative maximum 500 words) In 1998, a seminal study by Prof Angus Lamond FRS at the University of Dundee, in collaboration with Prof Matthias Mann (then based in EMBL, Heidelberg), provided insight into proteins that control the human spliceosome using mass spectrometry (1). This was one of the first studies to reveal the power of mass spectrometry to biologists and highlighted the potential of using this technique to simultaneously identify all or most of the proteins components of human macromolecular complexes, organelles and cells. In 2000-2001, research by Dr Paul Ajuh, then a postdoctoral fellow in the laboratory of Prof Lamond, provided further insight into the composition of the spliceosome complex and demonstrated the involvement of the CDC5L protein complex in spliceosome assembly (2,3). -
Metabolic Tracing of NAD Precursors Using Strategically Labelled Isotopes of NMN
A thesis submitted in fulfilment of the requirements for the degree of Doctor of Philosophy Metabolic tracing of NAD+ precursors using strategically labelled isotopes of NMN by Lynn-Jee Kim Supervisors Dr. Lindsay E. Wu (Primary) Prof. David A. Sinclair (Joint-Primary) Dr. Lake-Ee Quek (Co-supervisor) School of Medical Sciences Faculty of Medicine Thesis/Dissertation Sheet Surname/Family Name: Kim Given Name/s: Lynn-Jee Abbreviation for degree as give in PhD the University calendar: Faculty: Faculty of Medicine School: School of Medical Sciences + Thesis Title: Metabolic tracing of NAD precursors using strategically labelled isotopes of NMN Abstract 350 words maximum: (PLEASE TYPE) Nicotinamide adenine dinucleotide (NAD+) is an important cofactor and substrate for hundreds of cellular processes involved in redox homeostasis, DNA damage repair and the stress response. NAD+ declines with biological ageing and in age-related diseases such as diabetes and strategies to restore intracellular NAD+ levels are emerging as a promising strategy to protect against metabolic dysfunction, treat age-related conditions and promote healthspan and longevity. One of the most effective ways to increase NAD+ is through pharmacological supplementation with NAD+ precursors such as nicotinamide mononucleotide (NMN) which can be orally delivered. Long term administration of NMN in mice mitigates age-related physiological decline and alleviates the pathophysiologies associated with a high fat diet- and age-induced diabetes. Despite such efforts, there are certain aspects of NMN metabolism that are poorly understood. In this thesis, the mechanisms involved in the utilisation and transport of orally administered NMN were investigated using strategically labelled isotopes of NMN and mass spectrometry. -
The Victorian 2010 QUEEN VICTORIA SCHOOL 14 26
The Victorian 2010 QUEEN VICTORIA SCHOOL 14 26 Contents 1 List of Commissioners/Vision Statement 2 From the Head, Wendy Bellars 4 The Norman MacLeod MacNeil Trust Fund 5 Staff News 38 40 11 Careers 12 Senior Monitor 13 S5/6 Winter Formal 14 The Houses – Cunningham House 16 Haig House 18 Trenchard House 20 Wavell House 24 Sport – Rugby, Hockey, Sports Day, 42 56 Athletics 33 Hobbies & Activities 34 Pipe Band 36 Pink Day 37 Theatre 38 Field Trips – Malawi, Geography 42 Christmas Around the World 43 Primary 7 48 Academic 58 64 50 Eco Friendly 54 The Business Support Team 56 Duke of Edinburgh Award 58 Grand Day Rehearsal 60 CCF 68 OVA 69 Staff List QUEEN VICTORIA SCHOOL 1 Board of Her Majesty’s Vision Statement Commissioners for Ethos The Government of Queen Victoria School embodies, demonstrates and promotes the following values: Queen Victoria School • Integrity and honesty • Respect and responsibility Patron • Justice and equality HRH The Duke of Edinburgh KG KT OM GBE • Compassion and empathy Chairman Academic Professor B McGettrick The School strives to help each pupil realise his or her individual academic potential to the full at each Commissioners stage of his or her school life. The Right Honorable Lord Gill PC, The Lord Justice Clerk Non-Academic Major General D A H Shaw General Offi cer The School strives to provide a wide and diverse Commanding 2nd Division range of extra-curricular activities to develop the DJ Crawley Esq whole person. Mrs L Fisher Major General A R Freer OBE Civic and Service Responsibility Rear Admiral R Lockwood CB Queen Victoria School is an asset to the Ministry A J C Plumtree Esq of Defence, and through it to the personnel of the Brigadier P S Purves CBE Armed Forces. -
Breakthrough How Ideas Exchanged in the Canteen Can Lead to Research Discoveries
News from the Medical Research Council network Summer 2013 100 years of life-changing discoveries The greatcoffee breakthrough How ideas exchanged in the canteen can lead to research discoveries. Discoveries of the century Well-known figures give us their thoughts on the biggest medical advances, past and future. Network can also be downloaded as a PDF at: www.mrc.ac.uk/network CONTENTS NEWS News COMMENT FROM A phenomenal legacy begins 3 A phenomenal John Informatics research centres launched across the UK 3 legacy begins Speedier access to brain tissue for research 5 Savill Universities and Science Minister David Willetts has officially opened the MRC-NIHR Phenome Centre CHIEF EXECUTIVE at Imperial College London, which will re-purpose some of the sophisticated technology from the Royal opening for new LMB building 5 The launch of four e-health London 2012 Olympics Anti-Doping Centre. informatics research centres (eHIRCs) and the UK informatics Unlike our genome, which collectively describes a person’s genetic material, the phenome describes all the other chemistry of our research network by the Science body. It is the product of how our genes and environment interact throughout development and life, and is analysed by linking our Minister in May (see opposite), chemical, metabolic and physiological features and responses. By measuring phenome patterns throughout life, researchers at the Latest discoveries marked part of a £90m total centre aim to identify the patterns which separate those who develop particular diseases from those who don’t. investment in so-called big data or Gout drug offers hope for heart disease patients 10 medical bioinformatics research– something we excel at here in The centre’s first three pilot studies are now underway.