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Bone Abstracts May 2013 Volume 1 ISSN 2052-1219 (Online) Volume 31 March 2013 Volume 31

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Bone Abstracts May 2013 Volume 1 ISSN 2052-1219 (Online) Volume 31 March 2013 Volume 31 Society for Endocrinology BES 2012 19 –22 March 2012, Harrogate, UK Endocrine Abstracts Bone Abstracts May 2013 Volume 1 ISSN 2052-1219 (online) Volume 31 Volume March 2013 18-21 May 2013, Lisbon, Portugal published by Online version available at 1470-3947(201104)26;1-Y bioscientifi ca www.bone-abstracts.org EEJEA_31-1_cover.inddJEA_31-1_cover.indd 1 55/3/13/3/13 6:47:196:47:19 PPMM Volume 1 Bone Abstracts May 2013 ECTS 2013 18 – 21 May 2013, Lisbon, Portugal EDITORS The abstracts were marked by the Abstract marking panel selected by the Scientific Programme Committee ECTS 2013 Scientific Programme Committee Bente Langdahl (Aarhus, Denmark) Chair Members Tim Arnett Lorenz Hofbauer Maria Luisa Bianchi Aymen Idris Steven Boonen Pierre Marie Helena Canha˜o Stuart Ralston Richard Eastell Anna Teti Miep Helfrich Hans van Leeuwen Abstract Marking Panel KA˚ kesson Sweden EF Eriksen Norway U Kornak Germany E Paschalis Austria M Amling Germany A del Fattore Italy H Kronenberg USA M Rauner Germany D Arau´jo Portugal S Ferrari Switzerland M-H Lafage-Proust France J Reeve UK J Aubin Canada V Geoffroy France J Lian USA I Reid New Zealand F Baptista Portugal CGlu¨er Germany O¨ Ljunggren Sweden D Ruffoni Switzerland R Baron USA T Guise USA J Martin Australia N Sims Australia M Bouxsein USA E Hesse Germany T Matsumoto Japan J Tobias UK T Clemens USA M Kassem Denmark E McCloskey UK A Uitterlinden Netherlands C Cooper UK S Kato Japan K Michae¨lsson Sweden W Van Hul Belgium P Croucher Australia S Khosla USA RMu¨ller Switzerland R van’t Hof UK S Cummings USA R Kiviranta Finland MNodaJapan M-C de Vernejoul France ADı´ez Pe´rez Spain K Klaushofer Austria E Orwoll USA F de Vries Netherlands ECTS 2013 SPONSORS The ECTS would like to thank the ECTS 2013 sponsors Platinum sponsors: Lilly Gold Sponsors: Amgen Glaxo SmithKline MSD Other sponsors: Active Life Scientific Alexion Pharmaceuticals Biomedica Bioscientifica BioVendor Bruker Micro-CTT Faxitron Hologic International Bone & Mineral Society (IBMS) Immunodiagnostic Systems (IDS) Ltd John Wiley & Sons, Inc Kubtec Medivir OsteoMetrics Pharma-Vinci RISystem AG SCANCO Medical Stratec Medizintechnik GmbH TECOmedical/Quidel ECTS Secretariat 22 Apex Court Contact: Molly Ross Woodlands Tel: +44 (0)1454 642219 Bradley Stoke E-mail: [email protected] Bristol BS32 4JT, UK Web site: www.ectsoc.org ECTS 2013 Secretariat BioScientifica Ltd Contact: Rebecca Davies 22 Apex Court Tel: +44 (0)1454 642270 Woodlands E-mail: conferences@bioscientifica.com Bradley Stoke Website: www.ectscongress.org/2013 Bristol BS32 4JT UK Bone Abstracts (2013) Vol 1 ECTS 2013 CONTENTS ECTS 2013 OPENING CEREMONY ECTS 50th Anniversary Symposium: 50 years of research in bone and mineral metabolism . OPC1.1–OPC1.3 CLINICAL UPDATE Clinical Update 1 . .....................................CU1.1–CU1.6 Clinical Update 2 . .....................................CU2.1–CU2.6 ALLIED HEALTH PROFESSIONALS SESSION . AHP1.1–AHP1.4 MAIN SYMPOSIUM Developmental origins of metabolic bone disease . S1.1–S1.2 Muscles and bone . ...................................... S2.1–S2.2 Extreme bone phenotypes . ...................................... S3.1–S3.2 Energy metabolism and bone . ...................................... S4.1–S4.2 Uncoupling of resorption and formation . ...................................... S5.1–S5.2 CLINICAL DEBATE ................................................... D1.1–D1.2 WORKSHOPS Fat and bone . ..................................... W1.1–W1.3 Developmental biology and bone . ..................................... W2.1–W2.3 Vertebral fractures . ..................................... W3.1–W3.3 Osteoclast activity and haematopoiesis . ..................................... W4.1–W4.3 Anabolic bone therapies . ..................................... W5.1–W5.3 Cancer cells and Bone . ..................................... W6.1–W6.3 MEET THE PROFESSOR .............................................. MTP1–MTP15 EDUCATIONAL SYMPOSIUM ECTS-OARSI joint educational symposium on Osteoarthritis (Supported by Bioscientifica) . ES1.1–ES1.3 Approach to the finding of abnormal laboratory results (Supported by Alexion & IDS) . ES2.1–ES2.3 ORAL COMMUNICATIONS Osteoporosis epidemiology and long term treatment complications . OC1.1–OC1.6 Bone quality and fracture repair–animal models . OC2.1–OC2.6 Osteoporosis pathophysiology and genetics . .....................................OC3.1–OC3.6 Osteoblasts and osteocytes . .....................................OC4.1–OC4.6 Treatment of osteoporosis . .....................................OC5.1–OC5.6 Mineralisation and energy metabolism . .....................................OC6.1–OC6.6 NEW INVESTIGATOR WORKSHOPS ........................................NIW1–NIW3 NEW INVESTIGATOR SEMINAR ............................................ NI1–NI8 Bone Abstracts (2013) Vol 1 ECTS 2013 ORAL POSTERS Clinical . ....................................................... OP1–OP20 Pre-Clinical . ...................................................... OP21–OP40 POSTER PRESENTATIONS Clinical case posters . ....................................... PP1–PP12 Arthritis and other joint diseases: translational and clinical . PP13–PP30 Bone biomechanics and quality . ...................................... PP31–PP58 Bone development/growth and fracture repair . PP59–PP98 Calciotropic and phosphotropic hormones and mineral metabolism . PP99–PP131 Cancer and bone: basic, translational and clinical . PP132–PP162 Cell biology: osteoblasts and bone formation . PP163–PP212 Cell biology: osteoclasts and bone resorption . PP213–PP236 Cell biology: osteocytes . .....................................PP237–PP246 Chondrocytes and cartilage . .....................................PP247–PP266 Genetics . .....................................................PP267–PP283 Muscle, physical activity and bone . .....................................PP284–PP309 Osteoporosis: evaluation and imaging . .....................................PP310–PP340 Osteoporosis: pathophysiology and epidemiology . PP341–PP389 Osteoporosis: treatment . .....................................PP390–PP453 Other diseases of bone and mineral metabolism . PP454–PP501 Paediatric bone disease . .....................................PP502–PP508 Steroid hormones and receptors . ......................................PP509–P513 INDEX OF AUTHORS Bone Abstracts (2013) Vol 1 ECTS 2013 Opening Ceremony Bone Abstracts (2013) Vol 1 ECTS 2013 ECTS 50th Anniversary Symposium: 50 years of research resonance imaging (MRI), each opening new perspectives with in vivo three- in bone and mineral metabolism dimensional sectioning of the body. Quantitative computed tomography (QCT) was extensively investigated both for central and peripheral (pQCT) skeletal OPC1.1 imaging. The early isotope-based pQCT systems were converted to X-ray based systems in the late 1980s. Similarly, during this period, the SPA technique was advanced to dual photon absorptiometry (DPA), permitting quantitative imaging Abstract unavailable. of the central skeleton, mainly the spine and hip. At the same time pharmaceutical interest expanded in the area of osteoporosis therapeutics with exploration of a variety of estrogen and HRT regimens and the development of first and later generation bisphosphonates. Dual-X-ray absorptiometry (DXA) represented a DOI: 10.1530/boneabs.1.OPC1.1 major technological advance, replacing isotope-based DPA, and improving the speed, precision and spatial resolution, thus thrusting it into routine clinical practice. During the most recent 20 years, the DXA technology has further advanced from pencil-beam, single-detector to fan-beam multi-detector array, further improving OPC1.2 performance. Similarly, CT has evolved dramatically, to a high-resolution, fan- beam, multi-detector, spiral-scanning mode, greatly enhancing speed, coverage 50 Years of bone imaging and efficiency. Special purpose advanced Micro-CT systems have also been Harry Genant developed, these for imaging small animals and bone specimens, or for in vivo University of California, San Francisco, California, USA. imaging of the quasi-micro structure of the distal radius and tibia. Simultaneously over this time, MRI technology has continued its remarkable evolution, through Considerable progress has been made over the past half century in the many configurations, becoming today the most diverse and powerful medical development of imaging methods for assessing the skeleton noninvasively or imaging system. For both MRI and CT, the equipment and hardware advances nondestructively, so that osteoporosis can be detected early, its progression and have been accompanied by impressive developments in computer sciences and response to therapy monitored, and the risk of fracture determined. Clinicians and image processing, which have facilitated applications for analysis of skeletal researchers can now evaluate the peripheral, central, or entire skeleton as well as macro and microscopic structure, extending well beyond simple BMD measures. the trabecular, cortical, and endosteal envelopes with a high degree of accuracy In summary, the past 50 years has witnessed tremendous progress in the and precision, and they can reliably estimate bone strength and the propensity to development and application of bone imaging and bone densitometry techniques, fracture. The purposes of this presentation are to review the historical evolution of currently providing a vast array of exquisite research and clinical tools to examine the methods for bone imaging and bone densitometry, and to assess their current
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