RESEARCH ARTICLE Evolutionary history and spatiotemporal dynamics of the HIV-1 subtype B epidemic in Guatemala Yaxelis Mendoza1,2☯, Claudia GarcõÂa-Morales3☯, Gonzalo Bello4☯, Daniela Garrido- RodrõÂguez3, Daniela Tapia-Trejo3, Juan Miguel Pascale1, Amalia Carolina Giro n-Callejas5, Ricardo MendizaÂbal-Burastero5, Ingrid Yessenia Escobar-Urias6, Blanca Leticia GarcõÂa- GonzaÂlez6, Jessenia Sabrina Navas-Castillo6, MarõÂa Cristina Quintana-Galindo6, Rodolfo PinzoÂn-Meza6, Carlos Rodolfo MejõÂa-Villatoro6²³, Santiago Avila-RõÂos3³*, a1111111111 Gustavo Reyes-TeraÂn3³* a1111111111 1 Gorgas Memorial Institute for Health Studies, Panama City, Panama, 2 Department of Genetics and a1111111111 Molecular Biology, University of Panama, Panama City, Panama, 3 Centre for Research in Infectious a1111111111 Diseases, National Institute of Respiratory Diseases, Mexico City, Mexico, 4 LaboratoÂrio de AIDS e a1111111111 Imunologia Molecular, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Brazil, 5 Universidad del Valle de Guatemala, Guatemala City, Guatemala, 6 Infectious Diseases Clinic, Roosevelt Hospital, Guatemala City, Guatemala ☯ These authors contributed equally to this work. ² Deceased. OPEN ACCESS ³ Joint senior authors. Citation: Mendoza Y, GarcõÂa-Morales C, Bello G, *
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[email protected] (SAR) Garrido-RodrõÂguez D, Tapia-Trejo D, Pascale JM, et al. (2018) Evolutionary history and spatiotemporal dynamics of the HIV-1 subtype B epidemic in Abstract Guatemala. PLoS ONE 13(9): e0203916. https:// doi.org/10.1371/journal.pone.0203916 Different explanations exist on how HIV-1 subtype B spread in Central America, but the role Editor: Paul Sandstrom, Public Health Agency of of Guatemala, the Central American country with the highest number of people living with Canada, CANADA the virus, in this scenario is unknown.