Authors: Pallavi Subhraveti Ron Caspi Peter Midford Peter D Karp An online version of this diagram is available at BioCyc.org. Biosynthetic pathways are positioned in the left of the cytoplasm, degradative pathways on the right, and reactions not assigned to any pathway are in the far right of the cytoplasm. Transporters and membrane proteins are shown on the membrane. Ingrid Keseler Periplasmic (where appropriate) and extracellular reactions and proteins may also be shown. Pathways are colored according to their cellular function. Gcf_000716605Cyc: Streptomyces sp. NRRL F-525 NRRL F-525 Cellular Overview Connections between pathways are omitted for legibility. Anamika Kothari an amino an amino an amino an amino an amino an amino an amino an amino phosphate phosphate acid acid acid acid acid acid acid acid molybdate an amino an amino H + a dipeptide phosphate phosphate phosphate acid an amino acid an amino H + phosphate phosphate glycine betaine glycine betaine glycine betaine leu pro pro pro acid acid predicted predicted predicted predicted predicted predicted predicted predicted predicted predicted predicted predicted ABC ABC ABC ABC ABC ABC ABC ABC ABC ABC ABC F0F1 ATP ABC RS16420 RS10685 RS06340 RS46495 RS16425 ProP RS28920 RS26410 LeuE RS27350 RS38790 RS13800 transporter transporter transporter RS41005 transporter transporter transporter transporter transporter CoxB transporter transporter transporter synthase transporter of an of an of an of an of an of an of an of an of molybdate of phosphate of phosphate of a dipeptide amino acid amino acid amino acid amino acid amino acid amino acid amino acid amino acid a sugar RS40790 a sugar an amino an amino H + phosphate phosphate phosphate glycine betaine glycine betaine glycine betaine an amino an amino H + phosphate phosphate leu acid acid pro pro pro acid acid molybdate a sugar RS33225 a sugar phosphate phosphate an amino an amino an amino an amino an amino an amino an amino an amino a dipeptide acid acid acid acid acid acid acid acid

a sugar RS17620 a sugar

Amino Acid Degradation Chlorinated Degradation/ Compound Degradation a sugar RS17775 a sugar 5-methoxy-6- ditrans,octacis- a DNA containing 2-hydroxy-4-oxobutane- a [bis(guanylyl UDP-N-acetyl- a [protein]- (S)-4-hydroxy- (R)-4-hydroxy- 4-hydroxy- a [protein]-L- Utilization/ + serotonin a ribonucleoside 4-hydroxy- Ala mycofactocin biosynthesis Cofactor, Carrier, and Vitamin Biosynthesis Fatty Acid and Lipid Biosynthesis L-valine degradation I NaMN adenosylcobinamide a purine undecaprenyldiphospho- menadione NADH H an apurinic/ molybdopterin) α a glycyl-[tRNA ] 4-methyl-2- 4-methyl-2- cob(II)yrinate a,c-diamide [2Fe-2S] iron-sulfur mycothiol biosynthesis adeninyl adenosylcobamide biosynthesis Fermentation (S)-lactate fermentation to propanoate, acetate and hydrogen L-isoleucine degradation I L-threonine degradation I L-arginine degradation V L-leucine degradation I L-histidine degradation II 1,2-dichloroethane methylbenzimidazole 1,2,4-tricarboxylate cys -D-muramoyl- L-glutamine 2-oxopentanoate diphosphate dGDP methionine cob(II)yrinate a,c- superpathway of coenzyme A biosynthesis I (bacteria) flavin biosynthesis I (bacteria and plants) molybdenum cofactor biosynthesis L-arginine degradation XIII Assimilation - Other ribonucleoside β L-threonine oxoglutarate peptide- (arginine deiminase pathway) degradation N-acetyl-(N-acetyl- -D- apyrimidinic site cofactor L-alanyl-γ-D- ribonucleotide- oxoglutarate a C-terminal diamide biosynthesis I biosynthesis II (late cluster biosynthesis from adenosylcobinamide-GDP (reductive Stickland reaction) acrylonitrile 5'-triphosphate 4-carboxy-4- 4-carboxy-4- ribonucleotide- D-glucopyranose palmitate biosynthesis glucosaminyl)muramoyl- chaperone]- glutamyl-meso-2,6- diphosphate methionine a sugar RS17895 a sugar [mycofactocin cobalt incorporation) 3-methyl-2- a 5,10- fatty acid elongation -- saturated (S)-lactate val degradation I nicotinate-nucleotide-- 4-carboxy-4-hydroxy- transglutaminase 4-hydroxy-2- hydroxy-2- hydroxy-2- diphosphate (early cobalt insertion) 6-phosphate molybdate (type II fatty acid synthase) ile thr leu his 1,2-dichloroethane D-aspartate L-alanyl-γ-D-glutamyl-L- NADH-quinone L-cysteine diaminopimeloyl- (S)-S-oxide oxobutanoate methylenetetrahydrofolate endonuclease oxovalerate reductase: low specificity D-tyrosyl- oxoadipate oxoadipate precursor uroporphyrinogen-III L-cysteine desulfurase GTP arg arg histidine haloalkane dimethylbenzimidazole bifunctional lysyl-D-alanyl-D-alanine oxidoreductase: 2-oxoadipate domain-containing reductase: reductase uroporphyrinogen-III inositol-3- adenine threonine/serine branched-chain III: nth D-alanyl-D-alanine OO69_RS19920 L-threonine tRNA(Tyr) aldolase/ aldolase/ peptide]-glycyl-L-mycofactocin bifunctional predicted branched-chain branched-chain arginine deiminase: ammonia-lyase: acrylonitrile dehalogenase: phosphoribosyltransferase: adenosylcobinamide OO69_RS22360 aldolase/oxaloacetate protein: aldolase: dmpG OO69_RS19920 MsrA: msrA bifunctional 3-methyl-2-oxobutanoate phosphate molybdopterin an acetoacetyl-[acp] dehydratase: amino acid OO69_RS19925 aldolase: deacylase: valyl-L-tyrosine cysteine superpathway of thiamine diphosphate biosynthesis II ABC an acetoacetyl-[acp] amino acid arginine OO69_RS12995 nitrile hydratase cobT kinase/ bifunctional DNA- decarboxylase: cysteine OO69_RS22155 4-hydroxy-2- oxaloacetate oxaloacetate OO69_RS19925 a sugar RS25090 a sugar radical SAM uroporphyrinogen-III uroporphyrinogen-III GTP nicotinate-nucleotide-- amino acid OO69_RS13530 aminotransferase: OO69_RS00800 OO69_RS38555 OO69_RS22370 OO69_RS16130 peptide- a C-terminal desulfurase: hydroxymethyltransferase: synthase: aminotransferase: deiminase: subunit adenosylcobinamide- D-aspartate formamidopyrimidine OO69_RS29765 desulfurase: D-alanyl-D-alanine vitamin B12- OO69_RS01030 decarboxylase: decarboxylase: maturase: mftC C-methyltransferase/ cyclohydrolase II: transporter molybdopterin aminotransferase: arginine deiminase: [+ 2 isozymes] 2-chloroethanol nicotinate-nucleotide-- OO69_RS22375 nuoE transglutaminase oxovalerate vitamin B12- [mycofactocin C-methyltransferase/ OO69_RS23835 panB OO69_RS39400 dimethylbenzimidazole 3-oxoacyl- pyruvate OO69_RS23605 threonine OO69_RS12995 4-methyl-2-OO69_RS23605 ligase: glycosylase/ OO69_RS25690 carboxypeptidase/ dependent low specificity OO69_RS29765 OO69_RS29765 methionine uroporphyrinogen- OO69_RS36240 a [ThiS sulfur- of molybdate: adenylyltransferase: OO69_RS23605 OO69_RS35915 urocanate alpha: nthA dimethylbenzimidazole phosphate nuoF OO69_RS22390 4-carboxy-4-hydroxy- domain-containing aldolase: dmpG precursor peptide]- uroporphyrinogen- cys phosphoribosyltransferase: ACP ammonia-lyase: oxopentanoate acrylamide OO69_RS22450 DNA-(apurinic D-alanyl-D-alanine- ribonucleotide L-threonine dependent (S)-S-oxide III synthase: [+ 3 isozymes] [+ 2 isozymes] carrier protein] modA modB OO69_RS38940 3-methyl-2- arginine L-citrulline phosphoribosyltransferase: guanylyltransferase: nuoH nuoI 2-oxoadipate [+ 3 isozymes] protein: 4-carboxy-4- 4-carboxy-4- glycyl-L-valyl- III synthase: Ins(3)P UDP-N-acetyl- cobT reductase (3S)-3-methyl-2- OO69_RS36720 a tRNA Ala ribonucleotide reductase predicted 2,5-diamino-6- pyruvate carboxylase: oxobutanoate (2Z)-2-aminobut- deiminase: urocanate OO69_RS31010 OO69_RS22405 nuoK or apyrimidinic endopeptidase: dacB reductase: aldolase: gly OO69_RS21795 OO69_RS21795 an S-sulfanyl-[L- 2-dehydropantoate α-D-glucosamine sulfur carrier cysteine molybdopterin FabG: fabG oxopentanoate amidase: cobT aldolase/oxaloacetate OO69_RS32525 hydroxy-2- hydroxy-2- reductase: MsrA: msrA ABC decarboxylated (5-phospho-D- nicotinate-nucleotide-- molybdate 2-enoate OO69_RS35915 ornithine hydratase: ditrans,octacis- site) lyase: mutM a [bis(guanylyl [+ 2 isozymes] acetaldehyde pyruvate OO69_RS41840 OO69_RS14125 a protein-L- a sugar a sugar uroporphyrinogen-III cysteine desulfurase] protein ThiS desulfurase: D-glyceraldehyde adenine dinucleotide OO69_RS07855 adenosyl- OO69_RS22420 nuoN decarboxylase: a 2'- oxoadipate oxoadipate OO69_RS41840 transporter L-tyrosine uroporphyrinogen-III 2-dehydropantoate thioredoxin ribosylamino) dimethylbenzimidazole 3-oxoacyl- a 3-oxoacyl-[acp] 3-oxoacyl- carbamoyltransferase: OO69_RS32145 OO69_RS04570 chloroacetaldehyde undecaprenyldiphospho-N- ala molybdopterin) methionine- mycofactocin D-inositol-3-phosphate adenylyltransferase: OO69_RS23835 3-phosphate 5-methoxy-6- cobinamide NADH-quinone OO69_RS24400 a [protein] N 6 - deoxyribonucleoside aldolase/ aldolase/ of a sugar C-methyltransferase: C-methyltransferase: asp pathway phosphoribosyltransferase: [acyl-carrier- [acyl-carrier- L-citrulline 3-methylbutanoyl- argF [+ 6 isozymes] acetyl-(N-acetylglucosaminyl) GDP radical SAM 2-reductase: pyrimidin- glycosyltransferase: 4-imidazolone- nicotinate phosphate a purine cofactor UDP-N- 5'-diphosphate oxaloacetate oxaloacetate (S)-S-oxide cobA moeZ [+ 3 isozymes] 1-deoxy-D- molybdopterin protein] oxaloacetate formate acetyl-CoA CoA aldehyde methylbenzimidazole γ oxidoreductase a 3'-terminal a 5'-phospho- [(5-hydroxy-1H- glycolaldehyde cobA OO69_RS05705 4(3H)-one cobT protein] (2S)-2- 5-propanoate ribonucleoside muramoyl-L-alanyl- -D- chaperone]-S- D-ala acetylmuramoyl- gly maturase: mftC precorrin-1 aspartate 1- an oxidized mshA a carboxy- an [L-cysteine xylulose-5- molybdotransferase reductase: isobutanoyl-CoA acrylate dehydrogenase ribotide phosphate subunit NuoK: nuoK unsaturated sugar [DNA] indol-3-yl)ethyl]- decarboxylase: decarboxylase: predicted precorrin-1 reductase: methylbutanoyl- isovaleryl-CoA L-ornithine glutamyl-N-(β-D-asparatyl) sulfanyl-L-cysteine γ a C-terminal an S-sulfanyl-[cysteine 2-dehydropantoate thioredoxin adenylated-[ThiS desulfurase]-S- phosphate MoeA: malate dehydrogenase: phosphate 2-iminobutanoate imidazolonepropionase: 5'-diphosphate oxaloacetate pyruvate L-alanyl- -D- L-glutamine OO69_RS24400 OO69_RS24400 decarboxylase: adenine ribotide fabG fabG isobutyryl- CoA ornithine dehydrogenase: (NADP(+)): -L-lysyl-D-alanyl-D-alanine ABC [mycofactocin bifunctional desulfurase]-[disordered- 2-reductase: 1-O-(2-acetamido- sulfur-carrier protein] sulfanyl-L-cysteine synthase: OO69_RS38950 OO69_RS10040 acetyltransferase: pta OO69_RS32160 glutamyl-meso-2,6- pyruvate pyruvate a sugar a sugar bifunctional OO69_RS04725 α adenosylcobinamide- phosphate a (3R)-3- 3-oxoacyl- CoA:FAD 2-methylbutanoyl- carbamoyltransferase: OO69_RS29420 ornithine--oxo-acid OO69_RS26040 transporter precursor peptide]- uroporphyrinogen-III form scaffold OO69_RS45605 5-amino-6-(5- 2-deoxy- -D- OO69_RS35685 NAD + menadiol diaminopimeloyl- uroporphyrinogen-III GDP molybdopterin hydroxybutanoyl- oxidoreductase: CoA argF 3-methylcrotonyl- transaminase: rocD of a sugar glycyl-3-amino-5- C-methyltransferase/ protein] complex β phospho-D- D-ribulose glucopyranosyl)-1D-myo cysteine ACP (S)-malate H acetyl phosphate N-formimino- 2-chloroacetate D-alanine C-methyltransferase/ -alanine thioredoxin- AIR 1-deoxy-D- molybdotransferase 2 ornithine--oxo-acid [(4-hydroxyphenyl) [cysteine desulfurase]-S- (R)-pantoate 5-phosphate -inositol 3-phosphate desulfurase: gly [acp] reductase OO69_RS29420 dehydrogenase: CoA L-glutamate uroporphyrinogen- uroporphyrinogen- disulfide ribosylamino)uracil adenosylcobinamide- MoeA: transaminase: rocD predicted methyl]-4,4- sulfanylcysteine:[acceptor xylulose-5- FabG: fabG class II fumarate OO69_RS29420 2-oxobutanoate carbamoyl methylcrotonoyl- III synthase: reductase: bifunctional phosphomethylpyrimidine OO69_RS23835 GDP a (3R)-3- acetate kinase: methylacrylyl-CoA (E)-2- formimidoylglutamate a methylated a carboxy- 2-amino-4,5- a (1->4)- ABC III synthase: protein]-cysteine glycine phosphate OO69_RS37335 hydratase: OO69_RS43860 phosphate L-ornithine CoA carboxylase: a [2-oxoglutarate dehydrogenase E2 a [protein]- a 2-oxo (4R)-4-hydroxy- a [DNA]-3'- a 5'-phospho- a triacyl-sn a D-aspartyl- dimethylpyrrolidin- pantoate--beta- a 2,3,4-saturated a [protein]-L-lysine sec a sugar a sugar OO69_RS21795 trxB 3,4-dihydroxy- [+ 3 isozymes] OO69_RS37785 L-glutamate-5-semialdehyde deiminase: 5-methoxybenzimidazole NaMN 6 2-oxoglutarate nucleobase isobutanal a [glutamine- α OO69_RS21795 sulfurtransferase: synthase ThiC: thiC oxidase synthase: ribazoletransferase: hydroxyacyl-[acyl- methylcrotonoyl- protein] N -dihydrolipoyl-L-lysine adenylated- cys L-glutamine carboxylate L-ornithine 2-oxoglutarate hydroxyl [DNA] -glycerol dihydroxy-6-oxo- asp met ser a tRNA -D-glucan transporter 2-one alanine ligase: 2-butanone- fatty acyl-[acp] fumarate hydratase: glutamine- OO69_RS29435 OO69_RS32155 ATP synthetase]- [tRNA ] dADP 1,4-alpha- uroporphyrinogen-III uroporphyrinogen-III OO69_RS23835 5-amino-6-(5- 1-(2-acetamido- ThiO: thiO OO69_RS18400 OO69_RS31040 MoO -molybdopterin a (2E)-but- carrier protein] CoA multifunctional oxoglutarate within DNA [ThiS sulfur- 7-(phosphooxy) amino-acid N- of a sugar a thiocarboxylated- 2 OO69_RS43875 glycolate C-methyltransferase: a [cysteine desulfurase]- OO69_RS41415 phospho-D- 4-phosphate 2-deoxy-α-D- HMP-P acetate tiglyl-CoA hydrolyzing 3-methylglutaconyl- N-formyl- decarboxylase/oxoglutarate carrier protein] L-tyrosine heptanoate glucan C-methyltransferase: 1-deoxy-D-xylulose cofactor 2-enoyl-[acp] acetyltransferase: ribonucleotide- S-sulfanyl-[disordered- synthase/GTP [ThiS sulfur- 2-iminoacetate Coα-[α-(adenin-9-yl)]- hydrase: carbamoyl- CoA nicotinate-nucleotide-- acetaldehyde transglutaminase bifunctional non- triacylglycerol branching cobA cobA a reduced ribitylamino)uracil glucopyranosyl)- fumarate (S)-3-hydroxy- propanoyl-CoA L-glutamate dehydrogenase thiamine alpha- ornithine- D-tyrosyl- OO69_RS41380 serine--tRNA diphosphate predicted cyclohydrolase II: bifunctional carrier protein] 5-phosphate β enoyl-ACP phosphate dimethylbenzimidazole dehydrogenase domain-containing homologous lipase: enzyme: 3-amino-5-[(4- form scaffold (R)-pantothenate thioredoxin 1D-myo-inositol Co -adenosylcobamide isobutanoyl-CoA OO69_RS35630 pyrophosphate-binding ketoglutarate- -oxo-acid bifunctional [glutamine 4-hydroxy-2- tRNA(Tyr) reductase: ABC precorrin-2 hydroxymethylpyrimidine reductase N-formylglutamate cysteine OO69_RS00050 2-amino-4,5- bifunctional ligase: serS a sugar a sugar hydroxyphenyl) precorrin-2 protein] complex OO69_RS21395 N-acetyl-1-D-myo- 5'-phosphate fumarate reductase/ (2S,3S)-3- phosphate synthase: (S)-1-pyrroline-5-carboxylate phosphoribosyltransferase: subunit/dihydrolipoyllysine- dependent (acetylating): protein: transaminase: synthetase] oxoglutarate end-joining OO69_RS19920 glgB transporter cysteine kinase/ thiazole synthase: FabI: fabI amidohydrolase: desulfurase: dihydroxy-6-one- deacylase: glutamate N- serine--tRNA 1-deoxy-L- succinate dehydrogenase hydroxy-2- propionyltransferase: pta carA carB cobT residue succinyltransferase dioxygenase AlkB: OO69_RS11780 OO69_RS22155 rocD aldolase/2- DNA triacylglycerol methyl]-4,4- precorrin-2 C(20)- type III inositol-2-amino- OO69_RS32440 menaquinol-10 biosynthesis OO69_RS04915 OO69_RS25690 adenylyltransferase/ heptanoic acid- OO69_RS16130 ligase: serS OO69_RS19925 1,4-alpha- of a sugar precorrin-2 desulfurase: glycero-tetrulose phosphomethylpyrimidine flavoprotein: ATP methylbutanoyl- HMG-CoA pyrroline-5-carboxylate dehydro-3-deoxy- ligase: ligD lipase: acetyltransferase/ dimethyl-2- pantothenate ARP 2-deoxy-alpha- D- nicotinate-nucleotide-- subunit: OO69_RS20165 OO69_RS01765 acetaldehyde transglutaminase ornithine- [glutamine synthetase]- glucan dehydrogenase: methyltransferase: OO69_RS23835 kinase: OO69_RS02250 a butanoyl-[acp] biosynthesis CoA propanoyl carbamate [+ 3 isozymes] 7-phosphate amino-acid vitamin B12- pyrrolidin-2-one kinase: 4-phosphate glucopyranoside 2-[(2R,5Z)-2-carboxy- all-trans- OO69_RS04315 (S)-3-hydroxy- reductase: proC dimethylbenzimidazole dehydrogenase domain-containing adenylyl-L-tyrosine phosphogluconate [+ 3 isozymes] OO69_RS30660 predicted cobA cobI Coα-[α-(adenin-7-yl)]- phosphate hydroxymethylglutaryl- glu 2-oxoglutarate alpha- -oxo-acid synthase: acetyltransferase dependent branching mycofactocin [+ 3 isozymes] OO69_RS41400 deacetylase: mshB bifunctional 4-methylthiazol-5(2H)- 1,4-dihydroxy- acyl-CoA/acyl-ACP a trans-2- OO69_RS04320 isobutanoate phosphoribosyltransferase: (acetylating): protein: aldolase: eda an S-sulfanyl-[cysteine β decaprenyl ketoglutarate- transaminase: phosphorylase: asp sec enzyme: ABC 6,7-dimethyl-8- Co -adenosylcobamide a 2,3,4-saturated ADP CoA lyase: dehydrogenase, a thiocarboxylated- OO69_RS17225 tRNA D-aspartate ArgJ: argJ an L-seryl-[tRNA ] ribonucleotide a sugar a sugar biosynthesis precorrin-3A hydroxymethylpyrimidine ylidene]ethyl phosphate diphosphate 2-naphthoate dehydrogenase: enoyl-[acyl- acetate kinase: L-glutamate pro cobT OO69_RS07810 OO69_RS32525 OO69_RS31440 [+ 2 isozymes] transporter sirohydrochlorin desulfurase]-S- type I fatty acyl-[acp] fumarate reductase/ F0F1 ATP OO69_RS29425 L-tryptophan degradation to E2 component, dependent rocD a diacyl-sn N-acetyl-L- reductase: glgB FMN- ribityllumazine GlcN-Ins kinase/ OO69_RS00315 carrier protein] OO69_RS37785 degradation VI AMP ala [ThiS sulfur- [DNA] a fatty acid sulfanyl-[disordered- pantothenate pyridoxal 5'-phosphate biosynthesis I succinate dehydrogenase 2-methylacetoacetyl- 2-amino-3-carboxymuconate dihydrolipoamide dioxygenase AlkB: -glycerol methionine OO69_RS41840 starch of a sugar dependent synthase: adenosylcobinamide-GDP [+ 16 isozymes] synthase: atpB (to pyruvate) carrier protein] form scaffold kinase: phosphomethylpyrimidine a 3-oxohexanoyl- flavoprotein: CoA CO acetoacetate semialdehyde succinyltransferase: sucB OO69_RS13630 a protein with an a [glutamine DHAP L-aspartate 4- ADP OO69_RS21400 cysteine--1-D-myo- OO69_RS37515 (S)-methylmalonate- 2 5-methoxybenzimidazole + deaminase salvage from cobinamide I kinase: thiD D-erythrose propanoate nicotinate a [2-oxoglutarate dehydrogenase E2 isobutanoyl-CoA NADH H N 6 -(γ-glutamyl)- a proteinogenic L-glutamate-5- glyoxylate pyruvate predicted protein] complex OO69_RS09475 inosityl 2-amino- 2-(2-carboxy-4- [acp] OO69_RS46905 OO69_RS37520 glu ribotide phosphate synthetase]-O semialdehyde MftD: mftD [cysteine desulfurase]-S- semialdehyde 6 amino acid semialdehyde 4-phosphate benzimidazolyl adenosylcobamide OO69_RS46910 trp protein] N -S-succinyldihydrolipoyl-L-lysine L-lysine crosslink 4 ABC 5-[(4-hydroxyphenyl) cobalt- precorrin-3B sulfanylcysteine:[acceptor (R)-4'- 6,7-dimethyl-8-(1- 2-deoxy-alpha-D- HMP-PP methylthiazol-5- DMKH2-10 enoyl-ACP OO69_RS37525 acetyl-CoA C- a nucleobase -(5'-adenylyl) cob(II)inamide biosynthesis from adenosylcobinamide-GDP 3-oxoacyl- tryptophan 2,3- formaldehyde succinate a sugar transporter a sugar methyl]-3-imino-4,4- sirohydrochlorin protein]-cysteine phosphopantothenate D-ribityl)lumazine cob(I)yrinic acid glucopyranoside yl)ethyl phosphate ACP reductase OO69_RS37530 4-aminobutyrate CoA-acylating acyltransferase: L-threonine degradation IV within DNA -L-tyrosine dimethylpyrrolidin- demethylmenaquinone CDP-diacylglycerol FabI: fabI succinate OO69_RS35625 dioxygenase: of a sugar precorrin-3B C(17)- sulfurtransferase: bifunctional riboflavin a,c-diamide ligase: reductase propanoyl-CoA OO69_RS37535 aminotransferase, methylmalonate- thiamine benzimidazole biosynthesis I OO69_RS34455 2-one methyltransferase: OO69_RS23835 phosphopantothenoylcysteine OO69_RS28605 4-phospho- D-glyceraldehyde methyltransferase: atpD mitochondrial: gabT semialdehyde N-Formyl-L- a [cysteine synthase: adenosyltransferase: FabG: fabG L-serine degradation thr ditrans,octacis- UDP-N-acetyl-α-D- N-acetyl-muramoyl-(L- a peptidoglycan a mature a Xaa-Pro a [glutamine an N-terminal- cobJ decarboxylase/ phosphate D-erythronate pyruvate OO69_RS22330 OO69_RS37545 (2S, 3S)-3- kynurenine a D-tryptophanyl- phosphoenol 5-deoxy-D- predicted desulfurase]-(S- OO69_RS21385 cobO 3-phosphate nicotinate-nucleotide-- 3-oxoacyl- DHAP dehydrogenase: acetyl-CoA propanoyl-CoA 5-hydroxybenzimidazole NaMN γ oxaloacetate NADH 5-MTR-1-P deacetylmycothiol synthase: undecaprenyldiphospho-N- muramoyl-L-alanyl- alanyl- -D-glutamyl-L- dimer (E. faeciums) peptidoglycan dipeptidyl- synthetase]-O Trp L-methionyl-L- ala UDP-N-acetyl- glucuronate ABC cobalt-factor III phosphopantothenate-- mmsA methylaspartate (n) [tRNA ] dGDP pyruvate ATP roseoflavin precorrin-4 sulfanyl) -[disordered- cob(I)yrinic acid dimethylbenzimidazole menaquinol-10 [acyl-carrier- glycerol-3- (S)-3-amino-2- acetyl-(N-acetylglucosaminyl) γ-D-glutamyl-meso- lysyl-D-alanyl-D-alanine) (meso-DAP peptidase 4 -(5'-adenylyl) 4-carboxy-4-hydroxy- alanyl-[protein] α-D-muramate 5-deoxy- a sugar a sugar 2 cysteine ligase CoaBC: coaBC riboflavin OO69_RS32470 ATP ser D-alanyl-D-alanine 5'-phosphate S-methyl-5- transporter form scaffold a,c-diamide mycothiol 1-deoxy-D- phosphoribosyltransferase: protein] phosphate methylpropanoate threonine muramoyl-L-alanyl-γ-D- D-aspartate 2,6-diaminopimelate containing) substrate -L-tyrosine 2-oxoadipate glucuronate PMFT (R)-4'- D-alanyl-D-alanine NAD(+) thioribose-1- of a sugar precorrin-4 C(11)- protein] complex adenosyltransferase: synthase: xylulose-5- cobT reductase: dehydrogenase: threonine/serine aldolase: nicotinate-nucleotide-- aldolase/oxaloacetate isomerase: bifunctional (3R)-3-hydroxy-2-oxo- hydrogencarbonate isoglutaminyl-L-lysyl-D-alanine D-alanyl-D-alanine D-tyrosyl- type I methionyl phosphate methyltransferase: phosphopantothenoyl- mshD phosphate dehydratase: dimethylbenzimidazole carboxypeptidase/ UDP-N- diphosphatase: mycofactocin riboflavin kinase/ [corrinoid OO69_RS37565 thiamine phosphate 4 phosphooxybutanoate nicotinate-nucleotide-- fabG OO69_RS23315 (S)-methylmalonyl-CoA succinyl-CoA OO69_RS41425 L-kynurenine UDP-N- decarboxylase: tRNA(Tyr) aminopeptidase: pyruvate bifunctional isomerase: iolB predicted cobM L-cysteine synthase: sn-glycerol OO69_RS13530 phosphoribosyltransferase: carboxypeptidase/ D-alanyl-D-alanine- endolytic Xaa-Pro dipeptidyl- bifunctional [glutamine acetylmuramate-- nudC biosynthesis cobalt-precorrin-3 FAD synthetase: adenosyltranferase]- phosphoserine dimethylbenzimidazole a (3R)-3- mesaconate [+ 2 isozymes] acetylmuramoyl- OO69_RS29765 deacylase: map kinase: pyk riboflavin kinase/ mtnA 5-deoxy- ABC bifunctional mycothiol thiamine- OO69_RS35685 3-phosphate cobT D-aspartate ligase: D-alanyl-D-alanine- endopeptidase: dacB transglycosylase peptidase: synthetase] L-alanine ligase: a sugar a sugar glycosyltransferase superpathway of tetrahydrofolate biosynthesis OO69_RS35190 cob(II)inamide transaminase: phosphoribosyltransferase: hydroxyhexanoyl- L-serine tripeptide--D- FAD synthetase: glucuronate precorrin-5 a [cysteine desulfurase]- phosphopantothenoylcysteine methylmalonyl-CoA OO69_RS22450 endopeptidase: dacB [+ 2 isozymes] MltG: mltG OO69_RS18255 adenylyltransferase/ 4-carboxy-4-hydroxy- OO69_RS16130 [+ 2 isozymes] pyruvate OO69_RS35410 reduced β- S-methyl-5- transporter MftF: mftF cobalt-precorrin 3 phosphate kinase: 1-deoxy-D- cobT [acp] ammonia-lyase: nicotinate-nucleotide-- OO69_RS35190 [scaffold protein- serC mutase: OO69_RS37750 alanyl-D- alanine [+ 2 isozymes] [+ 3 isozymes] Xaa-Pro dipeptidyl- [glutamine synthetase]- 2-oxoadipate kinase: pyk thioribose-1- isomerase: of a sugar decarboxylase/ FMN OO69_RS23295 benzimidazole glycine cleavage OO69_RS23945 acetaldehyde gly dimethylbenzimidazole nicotinamide D- methyltransferase: precorrin- 4-phosphooxy- xylulose-5- methylmalonyl-CoA [+ 3 isozymes] 2-aminoprop- L-threonine ligase: murF adenylyl-L-tyrosine aldolase/oxaloacetate AMP iolB MFT-1 (2Fe-2S)] complex phosphopantothenate-- adenosylcobinamide- ribotide 3-hydroxy- a peptidoglycan peptidase: an N-terminal L- UDP-N-acetyl- ribonucleotide phosphate 5-dehydro- cobJ 6A synthase phosphate a 1-acyl-sn 2-enoate degradation III (to phosphoribosyltransferase: Trp roseoflavin cysteine ligase CoaBC: coaBC GTP bifunctional [corrinoid thiamine diphosphate L-threonine epimerase: mce a [glycine-cleavage acetaldehyde ditrans,octacis- OO69_RS08395 phosphorylase: decarboxylase: D-tryptophan a tRNA α-D-muramoyl- isomerase: predicted (deacetylating) GDP phosphate (S)-citramalate L-kynurenine cobT N-acetyl-muramoyl-(L- tetramer with a D-ala a mature GlcNAc-1,6- met alanyl-[protein] 2-deoxy-D- synthase: -glycerol 3- 6 dehydrogenase methylglyoxal) OO69_RS24400 pyruvate adenine ABC mycofactocin cobalt-precorrin-4 riboflavin kinase/ adenosyltranferase]- adenosylcobalamin (R)-methylmalonyl-CoA complex H protein] N glycine cleavage system undecaprenyldiphospho-N-acetyl- UDP-N-acetyl-α-D- alanyl-γ-D-glutamyl- D-ala peptidoglycan anhMurNAc- OO69_RS31440 L-alanine mtnA gluconate : cobF a (2E)-hex- D,D cross-link (n) dGTP S-methyl-5- a sugar a sugar 4'-phosphopantetheine cob(I)inamide OO69_RS18400 phosphate -[(R)-lipoyl]-L-lysine (acetylating): kynureninase: (N-acetylglucosaminyl)muramoyl- dinucleotide transporter biosynthesis a [co-chaperone]- GTP FAD synthetase: salvage from cobalamin adenosylcobinamide- 2-enoyl-[acp] aminomethyltransferase L-tryptophan thr muramoyl-L-alanyl- L-lysyl-D-alanine) (Enterococcus (meso-DAP L-Ala-γ-D-Glu- a dipeptide with pyruvate thio-D-ribulose cobalt precorrin- 1-acyl-sn-glycerol- citramalate OO69_RS11780 kynU L-alanyl-γ-D-isoglutaminyl-N-(β- of a sugar glycosyltransferase precorrin-6A [scaffold protein- cyclohydrolase OO69_RS35190 cob(I)yrinic acid 3-amino-1- 1-deoxy-D- GDP GcvT: gcvT degradation I L-threonine 3- 5-hydroxybenzimidazole nicotinate γ-D-glutamyl-meso- faecium) containing) DAP-D-Ala a C-terminal a peptide a [glutamine- 1-phosphate 11 pantetheine- enoyl-ACP 3-phosphate synthase: D-asparatyl)-L-lysyl-D-alanine MftF: mftF 4 (C )- I FolE: folE a,c-diamide cob(I)alamin ribazoletransferase: glycine cleavage system 2-iminopropanoate acetaldehyde dehydrogenase: ribotide phosphate 2,6-diaminopimeloyl- L-proline ADP synthetase]- (2Fe-2S)] complex phosphate FAD hydroxyacetone xylulose 5- reductase acyltransferase: aminomethyl- (via anthranilate) 3-hydroxyanthranilate methyltransferase: 7,8- adenosyltransferase: thiamine diphosphate salvage II aminomethyltransferase OO69_RS23565 dehydrogenase tdh D-alanyl-D-alanine L-tyrosine predicted MFT-2 adenylyltransferase: 1-phosphate phosphate OO69_RS31040 FabI: fabI OO69_RS42105 mixed acid fermentation transferring cobA dihydroneopterin cobO GcvT: gcvT trp (acetylating): L-2-amino-3- ABC coaD glycine a sugar a sugar cobalt- 3'-triphosphate 4-amino-2-methyl-5- Coα-[α- [+ 7 isozymes] OO69_RS07810 oxobutanoate transporter cob(I)yrinic acid cob(II)alamin a hexanoyl-[acp] a 1,2-diacyl- [+ 2 isozymes] dehydrogenase: tryptophan 2,3- acetate pyruvate di-trans,octa-cis γ (1E,4S,5E,7R)- precorrin-6B a [chaperone-ATP]- 3'-dephospho- phosphoenolpyruvate UDP-N-acetyl- a mature peptidoglycan 3'-dephospho- L-alanyl- -D- an N-terminal- phosphoenol a peptide with of a sugar precorrin-5A a,c-diamide pyrimidinemethanol (benzimidazolyl)]-Co sn-glycerol dioxygenase: NAD(P)H a plastoquinone H + an α L-rhamnoside a lipid II H O L-idonate digallate cyanate [co-chaperone]- gcvP pyruvate 2-amino-3- -undecaprenyl α-D-muramoyl- (meso-diaminopimelate glutamyl-L-lysyl- L-threo-3-phenylserine 2 L-methionyl-L- germacra-1(10) an N-terminal CoA cob(I)yrinic acid β-adenosylcobamide 5-methylbenzimidazolyl adenosylcobamide a [glycine-cleavage L-cysteine OO69_RS34455 acetyl-CoA ATP CoA GTP GTP 2-phospho- dADP pyruvate precorrin-6y C5,15- adenosyltransferase: bifunctional 3-phosphate a [glycine-cleavage N-Formyl-L- phosphatephospho-N- L-alanyl-γ-D- containing) D-alanyl-D-alanine seryl-[protein] ,5-dien-11-ol L-methionine L-idonate 5- tannase/feruloyl [scaffold protein- dephospho- pyridoxine 6 degradation II carboxymuconate- predicted 7,8- OO69_RS37565 a,c-diamide hydroxymethylpyrimidine 5'-phosphate biosynthesis from adenosylcobinamide-GDP 6 complex H protein] N - L-lactate MMFT-2 methyltransferase (2Fe-2S)] complex 5'-phosphate phosphatidate phosphoenolpyruvate pyruvate kinase: pyk complex H protein] N kynurenine 6-semialdehyde acetylmuramoyl- glutamyl-meso-2,6- dehydrogenase: esterase family CoA kinase: dihydroneopterin adenosyltransferase: kinase/ aminomethyldihydrolipoyl- aminoacetone NAD(P)H-quinone alpha-L- D-alanyl-D-alanine ABC (decarboxylating) cytidylyltransferase: carboxylase: ppc pyruvate kinase: pyk -dihydrolipoyl-L-lysine pentapeptide- diaminopimeloyl- germacradienol/ OO69_RS28490 alpha/beta cyanase:a sugar a sugar mycofactocin cobalt- OO69_RS47185 3'-phosphate adenosylcobinamide cobO pyridoxamine 5-methylbenzimidazole L-lysine cys endolytic dehydrogenase: rhamnosidase: D-alanyl-D-alanine low specificity L- carboxypeptidase/ ribosome type I methionyl type I methionyl transporter subunit CbiE: cbiE phosphomethylpyrimidine a 3-oxooctanoyl- OO69_RS23025 L-threonine transferase: D-alanyl-D-alanine triphosphoribosyl- 2-phospho-L-lactate L-idonate 5- hydrolase: cynS biosynthesis precorrin-5B 5'-phosphate primary-amine transglycosylase OO69_RS14035 carboxypeptidase/ threonine aldolase: D-alanyl-D-alanine- biogenesis aminopeptidase: pyruvate geosmin aminopeptidase: of a sugar cob(I)yrinic acid kinase: OO69_RS02250 Coα-[α- [acp] cystathionine degradation II OO69_RS32570 OO69_RS10710 guanylyltransferase: coenzyme A bifunctional nicotinate-nucleotide-- a CDP- oxaloacetate pyruvate L-arginine oxidase: MltG: mltG dephospho- D-alanyl-D-alanine- OO69_RS01030 endopeptidase: dacB map kinase: pyk synthase: map dehydrogenase: OO69_RS26365 glycosyltransferase precorrin-7 a,c-diamide oxidase: pdxH (benzimidazolyl)]-Co gamma-lyase: NAD(P)H:quinone alpha-L- GTPase a [chaperone- adenosylcobinamide bifunctional 3-oxoacyl- diacylglycerol biotin-carboxyl carrier degradation OO69_RS08190 L-glutamate CoA synthase: cofC pyruvate OO69_RS16935 OO69_RS22880 tannase/feruloyl MftF: mftF an [2Fe-2S] pyridoxal 5'- β dimethylbenzimidazole OO69_RS39515 L-kynurenine L-glutamate [+ 3 isozymes] rhamnosidase: endopeptidase: dacB low specificity L- [+ 2 isozymes] Der: der [+ 2 isozymes] [+ 2 isozymes] predicted ADP]-[disordered- D-erythro-7,8- chorismate kinase/ adenosyltransferase: hydroxymethylpyrimidine -adenosylcobamide ACP protein assembly L-glutamate 2-aminoprop- thr III (arginine OO69_RS38055 oxidoreductase: kinase: pyk 5-dehydro- ammonium CO precorrin-6y C5,15- phosphoribosyltransferase: degradation IX (via [+ 2 isozymes] threonine aldolase: esterase family 2 ABC cluster protein OO69_RS37565 kinase/ phosphate malate dehydrogenase: glycine cleavage system L-threonine 3- degradation II wrbA OO69_RS44395 [+ 6 isozymes] MMFT-3 cobalt- form scaffold dihydroneopterin adenosylcobinamide- cobT reductase degradation I 2-enoate decarboxylase/ methylglyoxal 4-aminobutanoate) L-lactyl-2- D-gluconate alpha/beta a sugar a sugar methyltransferase synthase: a [biotin carboxyl- aminomethyltransferase kynureninase: a mature peptidoglycan a mature peptidoglycan OO69_RS14125 an N-terminal transporter precorrin-6A protein] complex aminodeoxychorismate/ phosphate cob(II)alamin- phosphomethylpyrimidine FabG: fabG OO69_RS10040 dehydrogenase: agmatinase pathway) 2'-(5''-triphospho- a N- diphospho- acetone (-)-geosmin (decarboxylating) dihydroneopterin nicotinate-nucleotide-- carrier protein]-L-lysine GcvT: gcvT kynU undecaprenyldiphospho- with (L-alanyl-γ-D- strand (non- L-alanyl-γ-D- met met a peptide hydrolase: of a sugar mycofactocin NAD de novo biosynthesis anthranilate synthase [corrinoid kinase: thiD OO69_RS12920 tdh arg glu glu UMP β-L- a non D-ala acetylglucosamine- H + L-seryl-[protein] cobalt-precorrin- subunit CbiE: cbiE guanylyltransferase: L-2-amino-3- α-D-ribosyl)-3'- phosphate 5'-guanosine pyruvate OO69_RS24385 I (from aspartate) aldolase: folB dimethylbenzimidazole 3-oxoacyl- (R)-lactate glu L-asparagine aspartate N-acetylmuramoyl-L- glutamyl-meso-2,6- reducing terminus) adenine a plastoquinol + rhamnosylated glutamyl-L- D-ala GDP dATP biosynthesis 6A reductase: component II: OO69_RS31010 adenosyltranferase] biotin--[acetyl- (S)-malate acetyl-CoA formate glutamate dephospho-CoA NAD(P) rhamnopyranose -N-acetylmuramyl- HMP-P PLP phosphoribosyltransferase: [acyl-carrier- NAD-glutamate degradation I anthranilate oxobutanoate transaminase: alanyl-γ-D-glutamyl-meso diaminopimeloyl-D- rhamnosyl lysyl-D-alanine benzaldehyde gly gallate predicted glycosyltransferase OO69_RS26240 precorrin-8x 6-(hydroxymethyl) OO69_RS39190 CoA-carboxylase] 2-iminopropanoate decarboxylase: (tetrapeptide) an [Fe-S cluster -7,8-dihydropterin adenosyl-cobinamide cobT protein] ligase: class II fumarate dehydrogenase: glycine C- OO69_RS29770 -2,6-diaminopimeloyl- alanine) tetrapeptide acceptor pyrophosphoryl- ABC MftF: mftF cobalt- asp 4-amino-4- citrate synthase/ agmatine L-glutamate OO69_RS41570 a sugar a sugar precorrin-8X biosynthesis phosphate bifunctional reductase: OO69_RS10750 hydratase: phosphate acetaldehyde OO69_RS47015 L-glutamine asn acetyltransferase: L-glutamine asp D-alanyl-D-alanine undecaprenol transporter precorrin-6B L-aspartate 2-amino-4-hydroxy-6- deoxychorismate cob(I)alamin- adenosylcobinamide- 5-methylbenzimidazole methylcitrate synthase: degradation X glutamate MMFT-4 methylmutase: chaperone]-ATP hydroxymethylpyrimidine 2-methyladeninyl adenosylcobamide fabG a [biotin carboxyl- OO69_RS43860 acetyltransferase: pta dehydrogenase glutamate degradation I asparaginase: OO69_RS18515 degradation II of a sugar oxidase: hydroxymethyldihydropteridine aminodeoxychorismate bifunctional [corrinoid GDP ribotide phosphate OO69_RS30105 agmatinase: decarboxylase: cobalt-precorrin- OO69_RS46430 kinase/ biosynthesis from adenosylcobinamide-GDP a (3R)-3- carrier protein]-N (acetylating): dehydrogenase: OO69_RS02395 aspartate 15 OO69_RS41410 diphosphokinase: folK adenosylcobinamide adenosyltranferase] fumarate hydratase: L-aspartate speB a ring-opened 7- 10 7,8-didemethyl- 3-(D-glyceryl) sn-glycero-3- N-acetyl-β-D- a [LuxE]-S- mycofactocin 6B (C )- lyase: OO69_RS20810 phosphomethylpyrimidine hydroxyoctanoyl- 6 citrate synthase: CO H gly glu OO69_RS14130 an N - dCDP 2-iminosuccinate (7,8-dihydropterin- -biotinyl-L-lysine OO69_RS11780 2 2 OO69_RS18445 gln pyruvate asparaginase: ammonia- an L-methionyl- dioscin chitin 5'-deoxyadenosine tributyrin a DNA segment an L-cysteinyl- L-idonate predicted biosynthesis kinase/ cob(I)yrinic acid adenosylcobinamide- OO69_RS43875 OO69_RS47295 acetyl phosphate degradation I gln 4-aminobutanoate methylguanine 8-hydroxy-5- -diphospho- glu a (6S)-5- phospho-N- L-allo-threonine glucosaminyl-(1 (long-chain fatty a protein methyltransferase hydrogenobyrinate kinase: OO69_RS02250 2-methyladenine [acp] 2-oxoglutarate glutamate lyase: aspA [initiator tRNA Met ] formyltetrahydrofolate [tRNA Cys ] ABC 6-yl)methyl 4-aminobenzoate adenosylcobinamide- a,c-diamide acetaldehyde Asp-tRNA(Asn) OO69_RS16120 putrescine glutamate in DNA deazariboflavin 5'-guanosine formyltetrahydrofolate acyl)-L-cysteine recombinase L-idonate 5- ribonucleotide- a sugar a sugar glycosyltransferase [decarboxylating]: acyl carrier quinolinate GDP dehydrogenase: (arachidonoyl) -> 4)-N-acetyl- proteasome: transporter hydrogenobyrinate diphosphate phosphate adenosyltransferase: bifunctional fumarate dehydrogenase /Glu-tRNA(Gln) asp synthase large β RecA: recA dehydrogenase: diphosphate MftF: mftF OO69_RS46440 protein activation synthase 5-(2-hydroxyethyl) nicotinate-nucleotide-- ribazoletransferase: citrate acetate kinase: asp OO69_RS18445 fumarate ethanolamine -D-muramate beta-N- prcB prcA of a sugar a,c-diamide synthase: guanylyltransferase: cobO hydroxymethylpyrimidine a [biotin carboxyl- (acetylating): amidotransferase: subunit: gltB alpha-L- S-methyl-5'- triacylglycerol DDE-type OO69_RS28490 reductase: NadA: nadA -4-methylthiazole dimethylbenzimidazole OO69_RS31040 fumarate reductase/ OO69_RS37785 aspartate 2-oxoglutarate bifunctional DNA- methionyl-tRNA 2-phospho- bifunctional low specificity L- acetylhexosaminidase: long-chain- peptidyl-tRNA proteasome MMFT-5 dihydropteroate kinase/ carrier-protein dimer]- OO69_RS07810 gatB gatA gatC glu rhamnosidase: thioadenosine lipase: OO69_RS19920 cobalt-precorrin-7 OO69_RS46460 an apo acyl- OO69_RS31010 cob(I)yrinic acid phosphoribosyltransferase: a (2E)-oct- aconitate hydratase transaminase: L-alanine formamidopyrimidine formyltransferase: L-lactate folylpolyglutamate threonine aldolase: fatty-acyl-CoA integrase/ hydrolase: L-idonate 5- subunit synthase: folP phosphomethylpyrimidine hydroxyethylthiazole α α 6 succinate [+ 11 isozymes] OO69_RS14035 glycerophosphodiester beta-N- OO69_RS40800 phosphorylase: OO69_RS30660 OO69_RS19925 predicted hydrogenobyrinate carrier protein quinolinate adenosylcobinamide- a,c-diamide cobT Co -[ -(5- 2-enoyl-[acp] N -biotinyl-L-lysine AcnA: acnA acetate transferase: OO69_RS01030 reductase: transposase/ dehydrogenase: mycofactocin holo-ACP [+ 2 isozymes] kinase: thiD kinase: OO69_RS08780 dehydrogenase glu OO69_RS29770 degradation IV glycosylase/ OO69_RS27210 synthase/ phosphodiesterase: acetylhexosaminidase: beta-N- OO69_RS38985 OO69_RS35460 beta: prcB ABC bifunctional cobalt- a,c-diamide adenosyltransferase: methylbenzimidazolyl)]- acetyl-CoA oxaloacetate alpha-L- triacylglycerol recombinase: OO69_RS22880 vitamin B12- a sugar a sugar biosynthesis synthase: GDP nicotinate-nucleotide-- flavoprotein: acetaldehyde DNA-(apurinic methionyl-tRNA OO69_RS44160 dihydrofolate OO69_RS25415 low specificity L- OO69_RS40800 acetylhexosaminidase: OO69_RS01620 [+ 2 isozymes] a peptide transporter precorrin-7 (C(5))- carboxylating 4-methyl-5-(2- Coβ-adenosylcobamide enoyl-ACP carboxylase: cis-aconitate rhamnosidase: lipase: OO69_RS36430 5-dehydro- dependent putative OO69_RS37565 HMP-PP dimethylbenzimidazole OO69_RS04315 or apyrimidinic synthase: [+ 6 isozymes] threonine aldolase: of a sugar glycosyltransferase methyltransferase/ OO69_RS09525 nicotinate- 7,8- factor 420 reductase OO69_RS18585 ala formyltransferase: OO69_RS44395 beta-N- OO69_RS17950 5-deoxy-α- OO69_RS00050 a DNA segment ribonucleotide cobaltochelatase: a holo acyl- adenosylcob(III) phosphooxyethyl)thiazole 5'-phosphate biotin carboxylase: ethanol dehydrogenase: site) lyase: mutM OO69_RS40190 D-gluconate MftF: mftF nucleotide dihydropteroate phosphoribosyltransferase: polyglutamylation FabI: fabI OO69_RS04320 aconitate hydratase OO69_RS21230 oxidized 3PG- OO69_RS14125 acetylhexosaminidase: a [LuxE]- a long-chain D-ribose 1- in reverse cobalt-precorrin- carrier protein alamin-[corrinoid acetyl-CoA OO69_RS43715 OO69_RS10870 alanine adenine reductase: OO69_RS46470 cobT AcnA: acnA OO69_RS17950 L-cysteine phosphate orientation cys a tRNA Cys predicted 6B (C(15))- diphosphorylase: bifunctional adenosyltranferase] thiamine oxidized fumarate reductase/ dehydrogenase: ald factor 420-0 GMP sn-glycerol N-acetyl-D- fatty aldehyde OO69_RS41840 MMFT-6 cobaltochelatase an octanoyl-[acp] carboxylase: a [DNA]- 2,6-diamino-4- 3-O-β-D-glucosyl- anandamide chitin ABC methyltransferase: OO69_RS41405 folylpolyglutamate succinate ethanol pyruvate a 5'-phospho- an N-formyl- L-rhamnopyranose a (6S)-5- glucosamine butanoate 1,2-dibutyrin a sugar cob(I)yrinic acid phosphate Coα-[α-(5- factor 420-0 OO69_RS43720 4-oxo-2-pentenal a tetrahydrofolate diosgenin 3-phosphate acetaldehyde CDP a sugar OO69_RS46440 subunit CobN: cobN 2-methyladenine coenzyme D-threo-isocitrate nucleotide- [DNA] hydroxy-5-(N-methyl) L-methionyl- formyltetrahydrofolate gly N-acetyl-D- transporter mycofactocin synthase/ a,c-diamide synthase: methylbenzimidazolyl)]- a [carboxyl-carrier dehydrogenase NaMN F420-0:L- 3'-phosphate formamidopyrimidine met GlcNAc of a sugar cob(II)yrinate adenosylcobalamin biosynthesis adenosylcobinamide- ribotide phosphate 6 [initiator tRNA ] muramate biosynthesis dihydrofolate adenosyltransferase: OO69_RS32470 Coβ-adenosylcobamide protein dimer]-N - flavoprotein: NADP-dependent cobalt-precorrin-8 a,c-diamide GDP glutamate ligase: Respiration glycosyltransferase nicotinate-nucleotide synthase: cobO from adenosylcobinamide-GDP I carboxybiotinyl-L-lysine OO69_RS46905 OO69_RS44155 isocitrate predicted MftF: mftF OO69_RS40190 oxidized OO69_RS46910 a 7,8-dihydro- 7,8-didemethyl- enolpyruvoyl- an unstable cobalt-precorrin- adenylyltransferase: cob(I)yrinic acid a 3-oxodecanoyl- dehydrogenase: a CDP- a 3-O-acetylated 3-benzyl-3,6 - (S)-2-oxo-4- 5-dehydro- an N-terminal- UDP thiamine phosphate adenosylcobinamide- 2-oxoisovalerate decarboxylation to isobutanoyl-CoA sn-glycerol NAD(P)H H + a nucleoside a D-tyrosyl- acetyl-CoA ABC biotin biosynthesis from OO69_RS40380 7,8-dihydrofolate 5,6-dimethylbenzimidazole factor 420-1 OO69_RS04905 8-oxoguanine 8-hydroxy-5- 2-diphospho- phylloquinone rhamnogalacturonan I SAH bis(cysteinylglycine) hydroxy-4-carboxy- RNA 2-deoxy-D- L-methionyl-L- L-saccharopine RecA filament- a sugar a sugar 8 methylmutase: a,c-diamide GDP [acp] succinate 3-phosphate diacylglycerol Tyr ATP transporter MMFT-7 8-amino-7-oxononanoate I F420-1:γ- in DNA deazariboflavin 5'-guanosine triphosphate [tRNA ] acetyl-CoA ribonucleotide- DNA complex OO69_RS46430 nicotinate adenine monoglutamate adenosyltransferase: thiamine- Polyprenyl Biosynthesis an [apo BCAA - 6-(hydroxymethyl) 5-ureidoimidazoline gluconate 5-dehydro-2- valyl-[protein] biotin DNA folate transformations III (E. coli) nicotinate-nucleotide-- ribazoletransferase: bis(guanylyl molybdopterin) 3-oxoacyl- 2-oxoglutarate superpathway of pyrimidine Nucleoside and Nucleotide Degradation 2-oxo-4-hydroxy- diphosphate of a sugar dinucleotide glutamyl ligase: superpathway of purine deoxyribonucleosides degradation 5'-deoxyadenosine degradation II -diketopiperazine carboxylase: mycofactocin (8S)-8-amino-7- OO69_RS37565 phosphate kinase: dimethylbenzimidazole OO69_RS31040 cofactor sulfurylation dehydrogenase deoxyribonucleosides degradation rhamnogalacturonan 4-carboxy-5- deoxygluconokinase: reductase: repair dipyrromethane ACP 6 NAD(P)H-quinone cobyrinate + OO69_RS44155 fatty acid biosynthesis DNA-directed OO69_RS18585 biosynthesis oxononanoate NAD synthetase, OO69_RS23295 phosphoribosyltransferase: E2 protein] N alpha-ketoacid bifunctional DNA- CDP-diacylglycerol-- 2-phospho- acetylesterase: 5'-methylthioadenosine/ ureidoimidazoline iolC D-tyrosyl- type I methionyl saccharopine OO69_RS19920 protein predicted cofactor biosynthesis adenosylmethionine- a tetrahydrofolate adenosylcobalamin reductase initiation (type II) trans, trans-farnesyl 2'-deoxycytidine dehydrogenase: glycosyltransferase glutamine NAD(+) synthase: cobT Coα-[α-(2- oxidized geranyl diphosphate -lipoyl-L-lysine dehydrogenase 5'-deoxyadenosine formamidopyrimidine glycerol-3-phosphate 3- L-lactate OO69_RS17325 S-adenosylhomocysteine membrane decarboxylase: RNA polymerase 5-dehydro-2- tRNA(Tyr) aminopeptidase: dehydrogenase: biotin--[acetyl- acetyl-CoA RecO: ABC an apo- -8-amino-7- cys FabG: fabG diphosphate OO69_RS10710 OO69_RS19925 MftF: mftF dependent: OO69_RS31505 a 7,8-dihydrofolate thiamine diphosphate methyladenin-9-yl)]-Co factor 420-2 biosynthesis dihydrolipoyl subunit beta: 2'-deoxyguanosine glycosylase/ phosphatidyltransferase: transferase: nucleosidase: dipeptidase: OO69_RS10260 subunit omega: deoxygluconokinase: deacylase: map OO69_RS39705 CoA-carboxylase] carboxylase: a stabilizedrecO a sugar transporter a sugar [hydroxymethylbilane oxononanoate nicotinate-nucleotide-- 3-oxoacyl- acetyl-CoA biosynthesis NAD(P)H:quinone rhamnogalacturonan vitamin B12- OO69_RS31505 methionine β-adenosylcobamide Macromolecule Modification tRNA processing dehydrogenase: OO69_RS37280 nucleoside 5'-methylthioadenosine/ DNA-(apurinic pgsA OO69_RS44160 OO69_RS37840 OO69_RS15080 OO69_RS21190 OO69_RS16130 ligase: OO69_RS43720 transaminase: dimethylbenzimidazole cysteine 2'-deoxyadenosine oxidoreductase: acetylesterase: 2-oxo-4-hydroxy- 5-dehydro- iolC [+ 2 isozymes] dependent RecA filament- of a sugar MMFT-8 cob(II)yrinate synthase]-L-cysteine dihydrofolate [acyl-carrier- acetyl-CoA carboxylase: IPP lpdA deaminase: S-adenosylhomocysteine or apyrimidinic [+ 3 isozymes] OO69_RS10750 malonyl-CoA OO69_RS00065 synthase: metH phosphoribosyltransferase: 5'-phosphate IPP [+ 2 isozymes] OO69_RS25935 [+ 3 isozymes] 2-deoxy-D- DNA complex a,c-diamide NAD + reductase: bifunctional 5,10- desulfurase: protein] OO69_RS18585 OO69_RS22120 1-(3-sn- wrbA 4-carboxy-5- allysine ribonucleotide mycofactocin a [hydroxymethylbilane dihydrofolate methionine synthase: isopentenyl- a polycistronic dihydrolipoyl thymidine nucleosidase: site) lyase: mutM CMP glu a sugar RS31410 a sugar (7R,8S)-diaminononanoate OO69_RS14640 cobT OO69_RS23835 reductase: acetyl-CoA carboxylase: prenyltransferase: purine-nucleoside dehydro ureidoimidazoline gluconate 6- an N-terminal reductase: synthase] ES reductase: OO69_RS23790 methylenetetrahydrofolate diphosphate tRNA precursor dehydrogenase: [+ 5 isozymes] OO69_RS37840 phosphatidyl) S-ribosyl-L- Tyr biosynthesis 2 OO69_RS18865 factor 420-0 3-benzyl-3,6 - phosphate D-tyrosine a tRNA met biotinyl-5'- [+ 2 isozymes] dehydrogenase/5,10- α-ribazole [+ 3 isozymes] fabG OO69_RS43720 an [apo BCAA thymidine adenosine deaminase: phosphorylase: -sn-glycerol GMP a rhamnogalacturonan adenine homocysteine decarboxylase: uraD RNA L-valyl-[protein] OO69_RS41840 intermediate ATP-dependent OO69_RS14640 adenosylcobinamide- Delta- geranyl lpdA a [DNA]- + acetate adenylate glycosyltransferase molybdopterin biosynthesis serine Coα-[α-(2- an [L-cysteine a (3R)-3- malonyl-CoA an [apo BCAA dehydrogenase phosphorylase: OO69_RS10700 5-deoxy-D-ribose a 5'-phospho- 7,8-dihydro- NAD(P) phylloquinol type I bis(cysteinyl)- 6- gly (S)-(+)-allantoin hydroxymethylbilane methenyltetrahydrofolate GDP 5'-phosphate isomerase: idi dehydrogenase 2'-deoxyuridine OO69_RS40575 4-oxo-2-pentenal 3-phosphate dUDP MftF: mftF dethiobiotin a tetrahydrofolate [+ 2 isozymes]hydroxymethyltransferase: methyladenin-7-yl)]-Co desulfurase]-S- diphosphate E2 protein] N 6 -S-[2- purine-nucleoside nucleotide- (hydroxymethyl) hydroxydecanoyl- E2 protein] N 6 OO69_RS10525 [DNA] 8-oxoguanine a sugar RS09600 a sugar synthase: hemC synthetase a 7,8-dihydrofolate a 5-methyltetrahydrofolate cyclohydrolase: DMAPP phosphorylase: [+ 5 isozymes] S-methyl-5- 3'-phosphate OO69_RS23940 β-adenosylcobamide sulfanyl-L-cysteine [acp] ACP S- methylpropanoyl]dihydrolipoyl- -diketopiperazine MMFT-9 glycine cleavage system OO69_RS10845 -dihydrolipoyl- purine nucleotides degradation II (aerobic) hydroxymethylbilane BioD: bioD ATP [+ 3 isozymes] adenosylcobinamide- cysteine malonyltransferase: a tRNA precursor L-lysine thymine OO69_RS10700 purine-nucleoside thioribose pseudouridine aminomethyltransferase bis(guanylyl prenyltransferase: ribonuclease D: L-lysine synthase: hemC cys GTP bifunctional 5,10- GDP desulfurase: OO69_RS45405 with a 5' extension uracil phosphorylase: kinase: mtnK degradation a [hydroxymethylbilane dethiobiotin GcvT: gcvT a (6S)-5-formyltetrahydrofolate OO69_RS35620 a purine base 7,8-didemethyl- L-lactyl-2- a 2-O-acetylated p-nitrophenyl-α-L- UDP-N-acetyl- methyl β-D-glucoside an N-terminal- a [lipoyl-carrier a supercoiled a protein-L- heme a biosynthesis methylenetetrahydrofolate ribazoletransferase: molybdopterin) OO69_RS23835 OO69_RS18865 phosphorylase: 2'-deoxyinosine 3-phospho- ADP-α-D-glucose an L-cysteinyl- a sugar RS30610 a sugar and a long 3' trailer a tRNA precursor with OO69_RS10700 5-deoxy-α-D- 8-hydroxy-5- diphospho- rutin α a RNA-DNA hybrid urea-1-carboxylate L-methionyl- 6 methionine- synthase] ES cofactor NAD salvage pathway I (PNC VI cycle) AMP lesion in DNA D-glycerate rhamnogalacturonan I rhamnopyranoside -D-muramoyl- D-glt 6-phosphate protein]-N -[(R) glu ala duplex DNA Pro 3 methylenetetrahydrofolate dehydrogenase/5,10- 5-formyltetrahydrofolate OO69_RS31040 [+ 3 isozymes] a malonyl-[acp] OO69_RS10525 pseudouridine dGTP [tRNA ] intermediate biotin synthase cysteine GTP 3',8- thiamine diphosphate di-trans,poly-cis-undecaprenyl a (2E)-dec- geranyl a 5' extension and ribose 1-phosphate deazariboflavin 5'-guanosine L-alanine glycyl-[protein] -dihydrolipoyl]- ATP- (R)-S-oxide reductase: OO69_RS05505 methenyltetrahydrofolate cyclo-ligase: a [bis(guanylyl 2-oxo acid 2-deoxy-α-D-ribose 1-phosphate peptide- protoheme hydroxymethylbilane BioB: bioB desulfurase: cyclase biosynthesis I (E. coli) phosphate biosynthesis 2-enoyl-[acp] diphosphate a short 3' extension L-lysine dihydrolipoyl dependent a carboxy- cyclohydrolase: OO69_RS38960 adenosylcobalamin molybdopterin) NAD + ketoacyl-ACP synthase bifunctional S-methyl-5- bifunctional DNA- rhamnogalacturonan alpha-L- methionine protoheme IX synthase: hemC OO69_RS23835 MoaA: methylenetetrahydrofolate ribonuclease dehydrogenase glucosyl-3- alpha-L- bifunctional 6-phospho-beta- allophanate dehydrogenase: DNA a sugar RS17265 a sugar adenylated 2-[(2R,5Z)- OO69_RS05495 cofactor enoyl-ACP III: OO69_RS12635 prenyltransferase: ribonuclease D: metallophosphatase/ thioribose-1- pseudouridine 2-phospho- acetylesterase: rhamnosidase: UDP-N- type I methionyl glutamate-- Cys- (R)-S-oxide 9-mercaptodethiobiotin [+ 3 isozymes] reductase [NAD(P)H]: metF 5'-phosphate (2E,6E)-farnesyl [bis-MGD cofactor + P protein subunit E2: α formamidopyrimidine phosphoglycerate rhamnosidase: RNase H/acid glucosidase: hydrolase farnesyltransferase: hydroxymethylbilane moaA NAD synthetase, reductase OO69_RS18865 ribonuclease D: uracil 2-deoxy- -D- deoxyguanosinetriphosphate L-lactate aminopeptidase: lpdA cysteine ligase: helicase tRNA(Pro) [small subunit of an [L-cysteine (8S)-3',8-cyclo-7,8- 2-carboxy-4- a 5,10-methylenetetrahydrofolate a 5,10-methenyltetrahydrofolate diphosphate chaperone]- chaperone]-S- NAD(+) [+ 2 isozymes] OO69_RS35620 component: OO69_RS37275 5'-nucleotidase: phosphate 5'-phosphate glycosylase/ synthase: OO69_RS17325 OO69_RS14035 OO69_RS14035 acetylmuramoyl- phosphatase: OO69_RS17640 subunit 1: reductase OO69_RS25625 synthase: hemC isoprenyl glutamine FabI: fabI OO69_RS35620 ribose 1-phosphate triphosphohydrolase: transferase: map OO69_RS15075 RecG: recG molybdopterin desulfurase]-S- methylthiazol-5(2H bis-MGD sulfanyl-L-cysteine diphosphatase: rnpA OO69_RS36155 isomerase: mtnA DNA-(apurinic OO69_RS15610 rhamnogalacturonan alpha-L- L-alanine--D- OO69_RS19005 OO69_RS21585 dihydrolipoyl deacylase: MsrB: msrB ferroheme o a [hydroxymethylbilane biotin synthase dihydroguanosine bifunctional 5,10- transferase: dependent: (2E,6E)-farnesyl [+ 3 isozymes] IMP pseudouridine- OO69_RS33870 alpha-L- [+ 2 isozymes] a [protein]-L- synthase] sulfanyl-L-cysteine )-ylidene]ethyl NAD(+) synthase: a decanoyl-[acyl- an acetoacetyl-[acp] ribonuclease 2-deoxy-D-ribose 5-phosphate S-methyl-5- OO69_RS44160 acetylesterase: rhamnosidase: glutamate ligase: [+ 2 isozymes] dehydrogenase: [+ 2 isozymes] [+ 4 isozymes] ybaK a sugar RS03455 a sugar synthase] ES BioB: bioB 5'-triphosphate HMP-PP NAD salvage OO69_RS31505 nudC diphosphate or apyrimidinic rhamnosidase: [+ 2 isozymes] [+ 2 isozymes] a single 4 phosphate methylenetetrahydrofolate OO69_RS33545 a tRNA precursor with 5'-phosphate a [lipoyl-carrierlpdA methionine heme A synthase: cyclic pyranopterin pathway III (to OO69_RS31505 carrier protein] PH: rph adenosine GMP IMP thioribose-1- site) lyase: mutM α OO69_RS25935 OO69_RS44395 OO69_RS32575 intermediate dehydrogenase/5,10- adenosylcobalamin di-trans,octa-cis a short 3' extension glycosidase: 2-O-( -D- OO69_RS44395 β-D-glucose protein]-N 6 -[(R stranded DNA biotin RS40010 biotin biotin [+ 2 isozymes] nicotinate adenine polyribonucleotide 2-deoxy-D-ribose phosphate OO69_RS25645 hydroxymethylbilane monophosphate cytosolic NADPH production (yeast) nicotinamide riboside) NMN deoxyribose-phosphate dehydrogenase: oxidized ADP glucopyranosyl) MeOH an N-terminal γ-L-glutamyl- thiamine methenyltetrahydrofolate -undecaprenyl dinucleotide OO69_RS25395 triphosphate 6-phosphate )-lipoyl]-L-lysine Pro synthase: hemC synthase sulfo-bis(guanylyl a tRNA precursor nucleotidyltransferase: 5-phosphate aldolase: OO69_RS32885 adenosine bifunctional guaB isomerase: mtnA 2'-deoxyguanosine factor 420-0 a rhamnogalacturonan β-L- UDP-N-acetyl- DNA a nucleoside 5'- ammonium CO met cys a tRNA diphosphate + a [DNA]- GMP -3-phospho- β-L- 2 glycyl-[protein] D-alanine a sugar RS03835 a sugar a thiocarboxylated phosphate cyclohydrolase: NADP molybdopterin) OO69_RS35285 deaminase: a 5'-phospho- a modified acetate 4-nitrophenol quercetin- monophosphate ferroheme i hydroxymethylbilane MoaC: moaC nicotinate-nucleotide with a 5' extension deoxyribose-phosphate metallophosphatase/ 5-deoxy-D-ribulose uracil nucleotide- 4-oxo-2-pentenal D-glycerate type I rhamnopyranose α-D-muramoyl-L- synthase: NAD + OO69_RS10845 folate polyglutamylation undecaprenyl- [DNA] nucleobase rhamnopyranose 3-glucoside [small subunit of cyclic cofactor adenylyltransferase: a 3- ribonuclease ribonuclease D: deoxyribose- aldolase: deoC OO69_RS40575 5'-nucleotidase: XMP 1-phosphate 3'-phosphate alanyl-D-glutamate predicted synthase: hemC OO69_RS32470 [+ 2 isozymes] diphosphate phosphatidylserine and heme A synthase: a holo- molybdopterin pyranopterin OO69_RS40380 oxododecanoyl- PH: rph OO69_RS35620 phosphate [+ 5 isozymes] OO69_RS36155 ABC S-adenosyl-L-methionine salvage II NAD(+)/ phosphatase: + phosphatidylethanolamine ribonuclease a sugar RS29650 a sugar ectoine ectoine OO69_RS25645 [hydroxymethylbilane synthase] phosphate 10 a tetrahydrofolate NAD [acp] aldolase: transporter NADH kinase: an N -formyltetrahydrofolate OO69_RS27115 biosynthesis I bifunctional α β synthase] thiamine 3-oxoacyl- P protein acetaldehyde D-glyceraldehyde 3-phosphate inosine guanosine 5-amino-5-(4- a peptidoglycan dimer (meso 3-phospho- an NDP- - Nα,Nε-diacetyl-lysyl- an N-acetyl- - an N-terminal- a DNA containing a mycothiol a negatively a peptide with (3R,5S)-3- OO69_RS32885 a ferrocytochrome + an L-asparaginyl- a pectin 34 of ectoine hydroxyferroheme i OO69_RS18010 undecaprenyl- NAD(+) NaMN nicotinamide component: metallophosphatase/ hydroxybenzyl)- SAM -diaminopimelate containing) phenylacetate stearoyl-CoA D-glucose D-hexosaminide malonyl-CoA H L-methionyl-L- an N-terminal a cytidine lys hydroxy-1- phosphate ACP a CDP-diacylglycerol D-glycerate D-alanyl-D-alanine a mismatch S-conjugate Asn supercoiled DNA SAH glutathione nicotinamidase: deoxyribose- 5'-nucleotidase: b [tRNA ] Ile2 [+ 2 isozymes] serine bifunctional diphosphate diphosphatase: reductase CDP-diacylglycerol--serine rnpA acetaldehyde 6-(D-ribitylimino) 5 threonyl-[protein] DNA L-alanine in tRNA pyrroline-5- thiamine- biosynthesis OO69_RS40985 purine-nucleoside purine-nucleoside acetaldehyde DHAP a sugar RS28675 a sugar thiamine RS23015 thiamine adenosylhomocysteinase: hydroxymethyltransferase: folylpolyglutamate phosphatase: nudC FabG: fabG O-phosphatidyltransferase: phosphate dehydrogenase (acetylating) OO69_RS36155 -5,6-dihydrouracil topoisomerase carboxylatepyrroline-5- phosphate kinase: NADH NADP + Glycolysis aldolase: phosphorylase: phosphorylase: D-alanyl-D-alanine phenylacetate-- glucosyl-3- D-alanyl-D-alanine beta-N- type III polyketide G/U mismatch- mycothiol pectinesterase: OO69_RS44230 molybdopterin an N 10 - OO69_RS23940 synthase/ OO69_RS02380 pssA : OO69_RS11780 IV subunit A: carboxylate bis(guanylyl molybdenum OO69_RS23295 NMN nicotinate 3-oxoacyl- OO69_RS10700 OO69_RS10700 carboxypeptidase/ acyl-CoA acetylhexosaminidase: type I methionyl peptidyl-tRNA aminopeptidase OO69_RS17315 tRNA dihydrofolate di-trans,octa-cis cys glu a 3-sn-phosphatidyl- deoC UTP and CTP dephosphorylation I xanthosine CoA ligase: paaF phosphoglycerate carboxypeptidase/ synthase: specific DNA conjugate OO69_RS30085 cofactor) biosynthesis L-homocysteine formyltetrahydrofolate [+ 3 isozymes] phosphoribosyltransferase: acetaldehyde C1 Compound Utilization and Assimilation bifunctional FO D-alanyl-D-alanine- desaturase: OO69_RS40800 aminopeptidase: hydrolase: N: pepN lysidine(34) reductase: ferroheme a -undecaprenyl [acyl-carrier- L-serine Tetrapyrrole Biosynthesis glycolysis III (from glucose) phenylacetate-- synthase: D-alanyl-D-alanine- OO69_RS00270 glycosylase: amidase [+ 2 isozymes] thiamine NAD(+)/ glucose-6-phosphate NADP-dependent synthase: OO69_RS40990 dehydrogenase (acetylating) OO69_RS00480 type I DNA synthetase proC a sugar RS05160 a sugar nitrate RS44425 nitrate MoO - aldehyde bifunctional bifunctional protein] an uncharged tRNA D-glyceraldehyde UTP hypoxanthine guanine biosynthesis endopeptidase: dacB beta-N- map mug Mca: mca OO69_RS35460 [+ 3 isozymes] 2 diphosphate a 5,10- OO69_RS40190 phosphate phosphatidylserine CoA ligase: paaF OO69_RS15610 endopeptidase: dacB type III polyketide Hyp 5-methyltetrahydropteroyltriglutamate- NADH kinase: dehydrogenase: isocitrate dehydrogenase metallophosphatase/ nicotinate reductase: acetaldehyde : OO69_RS07810 formaldehyde oxidation protein CofGH: [+ 2 isozymes] [+ 2 isozymes] topoisomerase: TilS: tilS molybdopterin molybdopterin folylpolyglutamate glutamate-- decarboxylase: 3-phosphate formaldehyde formaldehyde [+ 2 isozymes] [+ 2 isozymes] acetylhexosaminidase: synthase: [+ 2 isozymes] - homocysteine S- OO69_RS18010 OO69_RS39615 dehydrogenase: (NADP(+)): methylenetetrahydrofolate 5'-nucleotidase: tetrapyrrole biosynthesis D-glucopyranose purine-nucleoside topA MeOH a pectate cofactor tetrahydrofolate salvage from synthase/ cysteine ligase: fabG OO69_RS06230 siroheme biosynthesis acetyl-CoA VII (THF pathway) OO69_RS43315 OO69_RS17950 methyltransferase: metE I (from glutamate) acetaldehyde CTP synthase: phosphorylase: oxidation III oxidation V 2-O-(α-D- OO69_RS12445 an apyrimidinic uracil NAD(+)/ glucose-6-phosphate OO69_RS04905 OO69_RS26040 bifunctional OO69_RS36155 a nucleoside a relaxed DNA 34 a sugar RS51555 a sugar 5,10-methenyltetrahydrofolate dihydrofolate a tetrahydrofolate OO69_RS15075 a (3R)-3- ROK family OO69_RS42000 (mycothiol-dependent) (bacillithiol-dependent) a peptidoglycan with phenylacetyl-CoA diphosphate an N-terminal L- GlcN-Ins a mercapturate ala a peptide a lysidine potassium- [+ 2 isozymes] folylpolyglutamate 1-(β-D cytidylyl molybdenum an L-1- dehydrogenase OO69_RS10700 formaldehyde a ferricytochrome glucopyranosyl) Nα,Nε-diacetyl- site in DNA molybdenum cofactor NADP NADH kinase: dehydrogenase: synthase: hydroxydodecanoyl- glucokinase: 7,8-didemethyl- AMP oleoyl-CoA diphosphate Asn Ile2 + + demethylmenaquinol- [+ 2 isozymes] UDP CTP synthase: D,D cross-links (meso- D-ala -3-phospho- an N-acetyl-β- met threonyl-[protein] asn tRNA in tRNA K transporting K guanylyltransferase: a 5,10- menaquinol-11 biosynthesis OO69_RS35925 OO69_RS25610 synthase/ menaquinol-7 biosynthesis ribofuranosyl) cofactor sulfurylation phosphatidylethanolamine uroporphyrinogen-III 5-oxo-L-proline metabolism (acetylating): formaldehyde formaldehyde 5'-deoxyadenosine b lysyl-D-alanine D-ala 8 biosynthesis II biosynthesis OO69_RS40190 [acp] glu OO69_RS32360 8-hydroxy-5- met diaminopimelate containing) 5 an alcohol ATPase met methenyltetrahydrofolate lipoate biosynthesis bifunctional OO69_RS11780 OO69_RS16945 D-glycerate D-hexosamine octoketide OO69_RS37340 bifunctional 5,10- 10 dihydrofolate nicotinamide cytidylyl molybdenum glutamate-- xanthine deazariboflavin all-trans- all-trans- an N - all-trans- γ-L-glutamyl- and incorporation I a [protein] with a [protein] with ROK family a 5,10- a sugar RS20855 a sugar NAD + synthase: tRNA ligase: uroporphyrinogen-III acetaldehyde 1,4-dihydroxy- octaprenyl methionine methylenetetrahydrofolate undecaprenyl 1,4-dihydroxy- NADPH formyltetrahydrofolate heptaprenyl 1,4-dihydroxy- L-cysteine cofactor (trioxo) glucokinase: CTP purine ribonucleosides degradation OO69_RS40190 OO69_RS23395 C-methyltransferase/ an N-terminal an N-terminal methylenetetrahydrofolate S-(hydroxymethyl) S-(hydroxymethyl) hemin RS19425 hemin 6-naphthoate bis(molybdenum NAD(+)/ dehydrogenase/5,10- an L-glutamyl- OO69_RS06565 dehydrogenase UMP diphosphate adenosyltransferase: diphosphate 2-naphthoate diphosphate 2-naphthoate an octanoyl-[acp] uroporphyrinogen-III L-glutamine L-glutamate mycothiol bacillithiol a [ribosomal a peptidoglycan a 2'- a dietary all- a D-5- a [2-oxoglutarate a glucosylated a reduced cofactor) NADH kinase: methenyltetrahydrofolate a 5,10- a (2E)-dodec- Glu (acetylating): bifunctional 5,10- a sulfurated pyridoxamine α OO69_RS21200 pyridoxal 5'-phosphate biosynthesis II an [MCD cofactor [tRNA ] D-glucopyranose thymine degradation protein S12] a ferrocytochrome palmitoyl-CoA 5-aminolevulinate DL-allothreonine dimer (S. aureus) deoxyribonucleoside oxaloacetate L-ornithine monosubstituted cys L-homocysteine dehydrogenase thr -amylose glycogenin OO69_RS18010 menaquinol-8 biosynthesis lipoyl(octanoyl) 2-enoyl-[acp] synthase: OO69_RS21795 OO69_RS07810 bifunctional methylenetetrahydrofolate S-(hydroxymethyl) S-(hydroxymethyl) [DNA] ITP trans-retinyl ester pyruvate 5'-phosphate factor 420 a sugar RS11185 a sugar menaquinone molybdenum cofactor cyclohydrolase: methylenetetrahydrofolate [sulfur carrier] 89 b 6 chaperone]-MCD adenosine L-aspartate 5 5'-triphosphate E2 protein] N pyridoxamine 1,4-alpha-glucan 1,4-alpha- NADPH- transferase glutamyl-tRNA uroporphyrinogen-III C- 6-phosphate metallophosphatase/ urate dehydrogenase/5,10- mycothiol mycothiol hydantoin Asp/Glu/hydantoin threonine/serine Co 2+ Co 2+ biosynthesis guanylyltransferase: [+ 2 isozymes] SAM OO69_RS10845 enoyl-ACP thymine CDP branching glucan RS11245 + aldehydo-D-ribose D-glyceraldehyde glutathione cysteine LipB: lipB reductase: glucose-6- acetyl-CoA 5'-nucleotidase: dehydrogenase: dehydrogenase: -dihydrolipoyl- 5'-phosphate dependent 2+ 2+ OO69_RS37340 NADP gln methyltransferase: cobA methenyltetrahydrofolate D-alanyl-D-alanine racemase: dehydratase: Ni Ni decarboxylase: 10 [+ 2 isozymes] bis(guanylyl tungstenpterin) demethylmenaquinol-8 a [lipoyl-carrier protein] reductase acyl--CoA ligase: triacylglycerol dihydrolipoyl enzyme: glgB branching an N - 5-phosphate 3-phosphate desulfurase: OO69_RS21785 precorrin-1 a [protein] with phosphate OO69_RS36155 adenosine deaminase: OO69_RS26505 OO69_RS26505 acyl-CoA serine bifunctional cystathionine L-lysine oxidase: pdxH F420 OO69_RS22190 bis(guanylyl DMKH2-11 cofactor biosynthesis demethylmenaquinol-7 N 6 -octanoyl-L-lysine FabI: fabI long-chain fatty cyclohydrolase: 30S ribosomal OO69_RS01540 carboxypeptidase/ lipase: N(5)-(carboxyethyl) OO69_RS11095 dehydrogenase: OO69_RS13530 formyltetrahydrofolate dimethylmenaquinone OO69_RS23835 an N-terminal 5- OO69_RS40575 phosphoenolpyruvate 1,4-alpha-glucan enzyme: glgB reductase: a sugar RS27795 a sugar molybdopterin) guanylyl molybdenum (S)-4-amino-5- isomerase: pgi OO69_RS10845 S-(hydroxymethyl) S-(hydroxymethyl) protein S12 desaturase: hydroxymethyltransferase: D-alanyl-D-alanine- DNA primase/ ornithine Asp/Glu/hydantoin beta-synthase: pyridoxal 5'- methyltransferase: lipoyl acid activation 5,6-dihydrothymine uridine acyl--CoA ligase: carboxykinase (GTP) OO69_RS00050 lpdA threonine npdG cofactor biosynthesis phosphoribosylglycinamide demethylmenaquinone pyridoxal 5'- demethylmenaquinone [+ 3 isozymes] bifunctional γ oxo-L-proline CMP [+ 5 isozymes] methylthiotransferase OO69_RS00480 OO69_RS23940 polymerase: synthase: OO69_RS32065 phosphate branching 1,4-alpha- a short a short cofactor OO69_RS27810 a dodecanoyl-[acp] oxopentanoate -L-glutamyl glucose-6- bifunctional 5,10- mycothiol mycothiol OO69_RS17240 endopeptidase: dacB triacylglycerol racemase: dihydrolipoyl ammonia-lyase: an oxidized demethylmenaquinol-8 formyltransferase: methyltransferase: GTP methyltransferase: a [cytidylyl molybdenum synthase: lipA a long-chain uroporphyrinogen-III glutathione dihydropyrimidinase: OO69_RS23180 : OO69_RS36640 OO69_RS24000 synthase: enzyme: glgB glucan chain RS30355 chain MoO - bis(tungstenpterin) phosphate glutamate-1- 5-phosphate phosphate S-methyl-5'- dehydrogenase: dehydrogenase: RimO: rimO [+ 2 isozymes] [+ 2 isozymes] [+ 2 isozymes] an L-5- OO69_RS47715 OO69_RS36720 2 demethylmenaquinone cofactor chaperone]- a [lipoyl-carrier fatty acid C-methyltransferase/ pyroglutamyl hydA bifunctional xanthosine adenosine inosine guanosine methylenetetrahydrofolate lipase: dehydrogenase: branching factor 420 molybdopterin OO69_RS09945 OO69_RS22330 cofactor synthase: OO69_RS22330 long-chain fatty isomerase: pgi OO69_RS10870 OO69_RS10870 [+ 12 isozymes] a [2-oxoglutarate OO69_RS12920 amylopectin a sugar RS21445 a sugar fatty acid fatty acid menaquinol-9 biosynthesis menaquinol-6 biosynthesis 6 semialdehyde peptidase: thioadenosine metallophosphatase/ dehydrogenase/5,10- OO69_RS30660 monosubstituted lpdA 2-oxobutanoate pdxS pdxT methyltransferase: cytidylyl molybdenum protein]-N -[(R)- uroporphyrinogen-III dihydropyrimidinase: 5-aminolevulinyl- L-cystathionine dehydrogenase enzyme: glgB cofactor molybdenum cofactor menaquinol-11 menaquinol-7 acid--CoA ligase: 2,1-aminomutase: OO69_RS45345 degradation II 5'-nucleotidase: methenyltetrahydrofolate a [ribosomal diphosphate a peptidoglycan N5-(L-1- hydantoin PLP a tetrahydrofolate OO69_RS22330 cofactor (sulfo-dioxo) dihydrolipoyl]-L-lysine synthase: OO69_RS21795 F6P hydA S-formylmycothiol S-formylbacillithiol 5'-deoxyadenosine an unsulfurated palmitoleoyl-CoA a ferricytochrome AMP CoA acetaldehyde phosphoenolpyruvate E2 protein] N 6 guanylyltransferase: molybdenum cofactor OO69_RS22240 OO69_RS26625 S-methyl-5'- OO69_RS36155 cyclohydrolase: met protein S12]-3- gly with D,D cross- D-ala IDP carboxyethyl) a glycogen serine serine demethylmenaquinol-9 demethylmenaquinol-6 menaquinol-8 uroporphyrinogen-III C- purine-nucleoside purine-nucleoside purine-nucleoside purine-nucleoside [sulfur carrier] b [DNA] -lipoyl-L-lysine RS41545 guanylyl OO69_RS37340 guanylyltransferase: [+ 17 isozymes] thioadenosine 3-(carbamoylamino)- methylsulfanyl- 5 link (S. aureus) -L-ornithine demethylmenaquinone PLP demethylmenaquinone a 3-oxotetradecanoyl- laurate a long-chain glutamate-1- 6-phosphofructokinase: S-methyl-5'- OO69_RS05495 all-trans-retinol a fatty acid a sugar RS11435 a sugar thr thr molybdenum OO69_RS37340 methyltransferase: cobA 5-oxo-L-proline cytidine phosphorylase: phosphorylase: phosphorylase: phosphorylase: 89 semialdehyde OO69_RS00230 thioadenosine 2-methylpropanoate L-aspartate methyltransferase: cofactor methyltransferase: [acp] fatty acyl-CoA OO69_RS10700 OO69_RS10700 OO69_RS10700 OO69_RS10700 a 5,10- OO69_RS22330 OO69_RS22330 long-chain fatty 2,1- precorrin-2 5-oxoprolinase [+ 2 isozymes] phosphorylase: β-ureidopropionase: pyrimidine deoxyribonucleotides methenyltetrahydrofolate bis(guanylyl 3-oxoacyl- dephosphorylation S-methyl-5'- DNA with adenine:7,8- serine serine menaquinol-9 menaquinol-6 acid--CoA ligase: aminomutase: subunit PxpA: β-D-fructose 1,6- OO69_RS38985 OO69_RS06450 formate formate a [DNA]-3'- a 5'-phospho- an N-formyl-L- 6-O-trans- 3-amino-5-[(4- a sugar RS22045 a sugar RS30810 tungstenpterin) cofactor ACP thioadenosine degradation I α bifunctional 5,10- cob(II)inamide NAD + MoO - hesperidin a ribonucleoside a single a D-aminoacyl- MoO - 5-chloromaleylacetate oxaloacetate O-phospho- RNA carbonic acid an unfolded thr thr OO69_RS24840 hemL precorrin-2 OO69_RS29795 bisphosphate nucleoside triphosphate -D-ribose-1-phosphate 2 methionylaminoacyl- dihydro-8- 2 cys methoxy-mycolyl- hydroxyphenyl) reductase 5-MTR-1-P methylenetetrahydrofolate ATP hydroxyl [DNA] GTP triphosphate stranded DNA [tRNA] ATP L-homoserine protein dehydrogenase: cobA (R)-3-amino-2- pyrophosphohydrolase: molybdopterin molybdopterin tRNA oxoguanine mismatch molybdopterin maleylacetate citrate synthase/ trehalose 6- methyl]-4,4- FabG: fabG [+ 17 isozymes] S-methyl-5'- dehydrogenase/5,10- chaperonin 5-aminolevulinate methylpropanoate OO69_RS31955 cofactor cofactor reductase: methylcitrate dimethyl-2- glu class II fructose- thioadenosine alpha-L- phosphate GroEL: groL lauroyl-CoA sirohydrochlorin dCTP dCMP 5'-methylthioadenosine/ methenyltetrahydrofolate ATP-dependent carbonic trehalose- a sugar RS00760 a metal a metal 3-oxoacyl- bisphosphate bifunctional OO69_RS05230 synthase: cystathionine ribonuclease pyrrolidin-2-onemycofactocin a sugar gln cyclohydrolase: cob(I)yrinic acid a,c-diamide peptide rhamnosidase: D-tyrosyl- A/G-specific phosphatase: chaperonin glutaminyl-tRNA Aminoacyl-tRNA Charging [acyl-carrier- porphobilinogen S-adenosylhomocysteine DNA ligase: molybdenum cofactor OO69_RS30105 anhydrase: cation cation aldolase: fbaA adenosyltransferase: deformylase: OO69_RS14035 DNA primase/ tRNA(Tyr) adenine molybdenum cofactor maleylacetate gamma-synthase: PH: rph biosynthesis GroEL: groL RS08930 biosynthesis via transamidation protein] synthase: hemB sirohydrochlorin nucleosidase: D-ribose 5-phosphate OO69_RS10845 OO69_RS00290 OO69_RS35435 trehalose-otsB nucleoside triphosphate OO69_RS37565 guanylyltransferase: OO69_RS04045 polymerase: deacylase: glycosylase: guanylyltransferase: reductase: citrate synthase: OO69_RS36740 FMN- reductase: chelatase: OO69_RS17085 OO69_RS37840 [+ 2 isozymes] [+ 4 isozymes] alpha-L- [+ 4 isozymes] trans-methoxy- a protein acetate acetate tRNA charging pyrophosphohydrolase: OO69_RS37340 OO69_RS23180 OO69_RS16130 OO69_RS41300 OO69_RS37340 OO69_RS27700 OO69_RS47295 dependent a sugar RS07305 a sugar porphobilinogen [+ 2 isozymes] triose-phosphate MTR 10 cob(I)yrinic acid a,c-diamide [+ 3 isozymes] rhamnosidase: 1,2- glu fabG lipoprotein posttranslational modification OO69_RS31955 an N - 5-chloro-3- a nucleoside RNA mono-mycolate deaminase adenosyltransferase: cobO OO69_RS44395 [+ 6 isozymes] dihydroxypropane- a (3R)-3- stearate biosynthesis isomerase: dUTP diphosphatase: dut formyltetrahydrofolate bis(guanylyl oxoadipate diphosphate hydroxymethylbilane siroheme S-methyl-5- adenylyl 1,2,3-tricarboxylate L-cystathionine MftD: mftD ser a tRNA ser hydroxytetradecanoyl- a [prolipoprotein]- OO69_RS25575D-glyceraldehyde dUTP dUMP [DNA] NMN an uncharged an apurinic site CO H O PMFT II (bacteria and plants) synthase: hemC DHAP thioribose formyltetrahydrofolate AMP molybdopterin) formate a L-methionylaminoacyl- molybdenum 2 2 Lys β a D-amino acid a sugar a sugar lys a tRNA [acp] L-cysteine 3-phosphate deformylase: purU adenosylcobinamide cofactor tRNA hesperitin-7-O- -L- ssDNA/pppN(pN) tRNA adenine within DNA RS44475 hydroxymethylbilane kinase: mtnK triphosphate cofactor Thr Pro Trp β-D-glucoside rhamnopyranose hybrid thr a tRNA pro a tRNA trp a tRNA prolipoprotein type I [+ 2 isozymes] n -1 gln a palmitoyl-[acp] synthase: hemC 5-hydroxy-CTP 5-hydroxy-CMP an L-glutamyl- serine- diacylglyceryl glyceraldehyde- 5-MTR-1-P Gln lysine-- -tRNA formate [tRNA ] a tRNA Ala ala arg a tRNA Arg tRNA asp asp preuroporphyrinogen transferase: 3-phosphate a sugar RS26135 a sugar Asp-tRNA(Asn) tRNA ligase: elongator ligase: a (2E)-tetradec- an O 6 - 3D-(3,5/4)- a 1-acyl-2- an [amino-group carrier 3''-O-acetyl- phe Phe cys Cys his His glu glu threonine- ile Ile gly Gly proline-- met Met met val Val leu Leu tyr Tyr tryptophan- OO69_RS32840 dehydrogenase: a [protein]- a [protein]- hydrogen sn-glycerol D-sedoheptulose (2E,6E)-farnesyl Asp-tRNA(Asn) a tRNA a tRNA a tRNA a tRNA a tRNA a tRNA Met initiator tRNA a tRNA a tRNA a tRNA a 3-oxooctadecanoyl- cob(II)alamin a 5-L-glutamyl- a proteinogenic leukotriene-C4 FAD a reduced leukotriene-D4 N-methyl-L- /Glu-tRNA(Gln) OO69_RS21900 -tRNA tRNA ligase: tRNA serS -tRNA 2-enoyl-[acp] bifunctional an amino acid methylguanine trihydroxycyclohexane- arachidonoyl- peroxide protein]-C-terminal-γ- 1-phosphate ADP-ribose a protein a protein /Glu-tRNA(Gln) [acp] a [prolipoprotein]- gap ATP [peptide] amino acid L-cysteine L-threonine thioredoxin 3-phosphate tryptophan diphosphate amidotransferase: asn Asn gln Gln ligase: thrS OO69_RS35075 ligase: trpS enoyl-ACP uroporphyrinogen-III in DNA 1,2-dione sn-glycerol (L-glutamyl)-L-glutamate L-glyceraldehyde zinc-dependent amidotransferase: tRNA a tRNA alanine- arginine- bifunctional aspartate- serine- S-1,2-diacyl-sn- [+ 2 isozymes] 3D-(3,5/4)- presqualene gatB gatA gatC 3-oxoacyl- C-methyltransferase/ 3-phosphate CTP acetylglutamate 3-phosphate metalloprotease: proteasome a sugar RS44555 a sugar gatB gatA gatC phenylalanine-- cysteine-- histidine-- -tRNA -tRNA lysylphosphatidylglycerol glutamate-- threonine-- isoleucine-- glycine-- proline-- methionine-- methionine-- -tRNA -tRNA valine-- leucine-- tyrosine-- tryptophan- reductase glyceryl-L-cysteine Inorganic Nutrient Metabolism trihydroxycyclohexane- FAD:protein FMN membrane class II fructose- O-acetyl- diphosphate [+ 11 isozymes] ACP uroporphyrinogen- methylated-DNA-- thioredoxin- kinase: argB reductase: mgrA N-methyl-L- OO69_RS41530 a 5-phosphooxy- tRNA ligase: pheS tRNA ligase: tRNA ligase: ligase: ligase: synthetase/lysine-- tRNA ligase: tRNA ligase: tRNA ligase: tRNA ligase: tRNA ligase: tRNA ligase: tRNA ligase: ligase: ligase: tRNA ligase: tRNA ligase: tRNA ligase: -tRNA FabI: fabI 13-DPG cob(I)yrinic acid a,c-diamide gamma- gamma- 1,2-dione acylhydrolase bisphosphate ADP-ribose synthase ATPase: arc reductase III synthase: [protein]-cysteine S- transferase: dependent dipeptidase: L-glutamyl- OO69_RS20475 OO69_RS15800 OO69_RS21025 alaS argS tRNA ligase LysX: lysX OO69_RS23395 OO69_RS20905 OO69_RS32625 OO69_RS33575 OO69_RS23140 OO69_RS36990 OO69_RS36990 aspS serS OO69_RS40185 OO69_RS40435 OO69_RS42890 ligase: trpS signal peptidase adenosyltransferase: cobO glutamyltransferase: glutamyltransferase: (decyclizing): iolD phosphatidate an [amino-group carrier L-glyceraldehyde tryptophan aldolase: fbaA deacetylase: [+ 2 isozymes] HpnD: hpnD ammonium FabG: fabG selenate reduction methyltransferase: OO69_RS20610 thiol OO69_RS15080 an unfolded Gln a myristoyl-[acp] OO69_RS21795 II: OO69_RS32640 phosphoglycerate assimilatory assimilatory OO69_RS08195 OO69_RS08195 cytidylyltransferase: protein]-C-terminal- 3-phosphate oxidase: solA OO69_RS06385 a sugar RS07385 a sugar [tRNA ] dimethyl sulfide urea cycle sulfate activation polyphosphate cob(I)yrinic acid a,c-diamide 3D-(3,5/4)- [+ 2 isozymes] [+ 3 isozymes] a peptide squalene an L-methionyl- 3-oxoacyl- OO69_RS03365 OO69_RS23025 peroxidase: γ protein an L-phenylalanyl- an L-asparaginyl- an L-glutaminyl- an L-cysteinyl- an L-histidyl- an L-alanyl- an L-arginyl- an L-lysyl- an L-glutamyl- an L-threonyl- an L-isoleucyl- an L-prolyl- an L-methionyl- an L-aspartyl- an L-seryl- an L-valyl- an L-leucyl- an L-tyrosyl- an L-tryptophanyl- uroporphyrinogen- kinase: sulfate reduction IV degradation sulfate reduction III for sulfonation metabolism adenosyltransferase: [+ 2 isozymes] [+ 2 isozymes] -(5-phospho-L- reductase: mgrA synthase Gly an (S-diacyl-sn- trihydroxycyclohexane- bcp L-glyceraldehyde Phe Asn Gln Cys His Ala Arg Lys Glu Thr Ile a glycyl-[tRNA ] Pro [elongator Met asp ser Val Leu Tyr Trp [acyl-carrier- a lipoprotein selenate [+ 3 isozymes] D-erythrose Asp-tRNA(Asn) [tRNA ] [tRNA ] [tRNA ] [tRNA ] [tRNA ] [tRNA ] [tRNA ] [tRNA ] [tRNA ] [tRNA ] [tRNA ] [tRNA ] [initiator tRNA ] [tRNA ] [tRNA ] [tRNA ] [tRNA ] [tRNA ] [tRNA ] III synthase: OO69_RS25570 II (oxidation) OO69_RS37565 glutamyl)-L-glutamate DHAP HpnC: hpnC Met glyceryl)-L-cysteinyl- 1,2-dione acylhydrolase 3-phosphate /Glu-tRNA(Gln) tRNA ] protein] OO69_RS44420 signal peptide sulfate sulfate sulfate arg long chain α a [protein]-FMN- a CDP-1-acyl- formaldehyde acetate ADP-D-ribose [apolipoprotein] sulfate an -(5-L- α γ (decyclizing): iolD leukotriene-E4 trp squalene a sugar 3-phospho-D-glycerate adenylyltransferase dimethyl sulfide sulfate an -( -L-glutamyl) a [protein]-S- L-threonine gly RS26325 a sugar amidotransferase: reductase: sulfate sulfate polyphosphate glutamyl)- a peptide leukotriene-D4 5-deoxy-D- AMP 2-arachidonoyl- an oxidized H O a 3-oxohexadecanoyl- uroporphyrinogen-III apolipoprotein N- adenosylcobalamin -L-amino acid a guanine in DNA 2 gatB gatA gatC fabG subunit CysD: cysD adenylyltransferase adenylyltransferase ammonium adenylyltransferase triphosphate amino acid methyl-L-cysteine glucuronate glycerol thioredoxin acyltransferase: lnt phosphoglyceromutase: [acp] a (3R)-3- sulfate subunit CysD: cysD subunit CysD: cysD argininosuccinate subunit CysD: cysD hydroxyoctadecanoyl- [+ 2 isozymes] OO69_RS15910 RNA an L-glutaminyl- 3-oxoacyl- an N-acyl-(S-diacyl- a peptide adenylyltransferase sulfate dimethyl sulfoxide sulfate lyase: argH glutamine- sulfate a sugar RS01275 a sugar [acp] degradosome Gln Nucleoside and Nucleotide Biosynthesis ACP sn-glyceryl)-L- subunit CysD: cysD adenylyltransferase hydrolyzing 4 [tRNA ] 2-phospho-D-glycerate adenosine 5'- adenylyltransferase adenylyltransferase polyphosphate UDP-N-acetyl-α-D-muramoyl- a [protein]- an O - an sn-glycero-3- cyclic luteolin 7-O-β- D-sedoheptulose 2''-O-acetyl- 4-methyl-3- subunit CysD: cysD di-trans,octa-cis- a proteinogenic an adenosine 37 an alkylated DNA naringin an L-aspartyl- enterobactin reductase cysteinyl-[lipoprotein] subunit CysD: cysD carbamoyl- subunit CysD: cysD L-alanyl-γ-D-glutamyl-L- ala a pimeloyl-[acp] glutathione methylthymine phospho-N-(acyl) DMAPP dehypoxanthine a protein ADP-ribose a protein oxoadipate- phosphoselenate L-arginino- kinase: undecaprenyl phosphate L-cysteine [tRNA Asn ] D-glucuronide 1,7-bisphosphate FabG: fabG phosphopyruvate APS APS L-ornithine phosphate APS amino acid in DNA in tRNA futalosine enterochelin enol-lactone a sugar superpathway of pyrimidine succinate OO69_RS16390 lysyl-D-alanyl-D-alanine ethanolamine Asp-tRNA(Asn) ATP-dependent zinc ATP-dependent 3-oxoadipate RS12140 a sugar superpathway of superpathway of guanosine pyrimidine deoxyribonucleotides de novo biosynthesis III 5-aminoimidazole ribonucleotide biosynthesis I guanine and guanosine salvage II hydratase: eno synthase: esterase: fes ribonucleotides de novo biosynthesis inosine-5'-phosphate biosynthesis I adenine and 3-oxoacyl- phosphoadenylyl- /Glu-tRNA(Gln) metalloprotease Clp protease: adenosine nucleotides nucleotides de novo biosynthesis I a (2E)-octadec- adenylyl-sulfate dimethyl sulfone adenylyl-sulfate [+ 2 isozymes] DNA-3- alpha-L- beta- class II fructose- O-acetyl- enol- adenosine [acyl-carrier- phosphopyruvate carA carB cyanate degradation phospho-N- methylated-DNA-- tRNA (adenosine(37)-N6) enterochelin Aromatic Compound Biosynthesis de novo biosynthesis I UDP CTP 2-enoyl-[acp] kinase: cysC sulfate reductase: 8-amino-7- gamma- glycerophosphodiester rhamnosidase: 1,4-dihydroxy- amidotransferase: glucuronidase: FtsH: ftsH bisphosphate ADP-ribose OO69_RS40165 lactonase: PRPP salvage VI protein] periplasmic disulfide bond formation hydratase: eno dimethyl sulfone kinase: cysC [protein]-cysteine S- -dimethylallyltransferase methyladenine esterase: fes gln AIR vitamin B12-dependent selenite OO69_RS17125 carbamoyl acetylmuramoyl- oxononanoate glutamyltransferase: phosphodiesterase: OO69_RS14035 6-naphthoate gatB gatA gatC ATP-dependent zinc deacetylase: N-(2,3- OO69_RS40170 pcaD a metal a metal hydrogencarbonate guanosine enoyl-ACP adenylyl-sulfate adenylyl-sulfate glycosylase: an L-asparaginyl- uidA aldolase: fbaA RS08925 IMP reductase: monooxygenase phosphate long chain CO carbonic pentapeptide- synthase: OO69_RS08195 methyltransferase: OO69_RS22770 MiaA: miaA synthase: OO69_RS06385 clpX 4-methyl-3- cation cation chorismate biosynthesis I IMP ribonucleotide reductase: a [DsbB protein] a [DsbA protein] two reduced phosphoenolpyruvate ornithine 2 alpha-L- Asn metalloprotease dihydroxybenzoyl) 2,3-dihydroxybenzoate 5-(carboxyamino) amidophosphoribosyltransferase: fabG reductase kinase: cysC SfnG: sfnG sulfite kinase: cysC polyphosphate OO69_RS03365 OO69_RS43025 [tRNA ] oxoadipate 3-(4-hydroxyphenyl) asp OO69_RS41840 CDP adenosine an electron- with reduced L- carrying a cysteine residues argininosuccinate carbamoyltransferase: anhydrase: transferase: OO69_RS00075 [+ 2 isozymes] [+ 6 isozymes] OO69_RS15405 FtsH: ftsH -L-serine [+ 3 isozymes] imidazole ribonucleotide OO69_RS36030 FabI: fabI rhamnosidase: D-erythrose biosynthesis a (3R)-3- transfer quinone synthase: argG OO69_RS32570 [+ 3 isozymes] N 6 -(3-methylbut- β-D-glucuronate D-erythrose pyruvate glutamine- IMP adenosine kinase: cysteine residues disulfide bond in a protein pyruvate PAPS methanesulfinate argF PAPS OO69_RS35435 OO69_RS44395 luteolin a peptide DHAP a peptide synthase: OO69_RS44050 ribonucleotide- vitamin B12-dependent β hydroxyhexadecanoyl- assimilatory sulfite an alkylated a DNA containing 4-phosphate ADP-D-ribose 4-phosphate biosynthesis hydrolyzing dehydrogenase: 5-phospho- - gly a stearoyl-[acp] kinase: pyk L-citrulline [+ 4 isozymes] 2-en-1-yl)- acetate a metal a metal 3-deoxy-7- chorismate adenylosuccinate diphosphate reductase: ribonucleotide reductase: guanine OO69_RS18235 phosphoadenylyl- reductase (NADPH) (8S)-8-amino-7- an α-(γ-L-glutamyl) an N- an apurinic/ 1,4-dihydroxy- an unknown RS18315 carbamoyl- guaB D-ribosylamine [acp] selenodiglutathione a [protein]-S- sn-glycerol adenosine 37 nucleobase cation cation N5-CAIR OO69_RS19920 OO69_RS41840 pyruvate : OO69_RS17135 undecaprenyl-diphospho-N- UMP oxononanoate acyl-carrier protein L-cysteinylglycine a thymine in DNA apyrimidinic site β 6-naphthoate compound phosphoheptulonate isochorismate tyr synthase: AMP sulfate reductase: -L-amino acid methyl-L-cysteine 3-phosphate acylethanolamine in tRNA -L- phosphate OO69_RS19925 kinase: pyk glyphosate acetylmuramoyl-L-alanyl-γ-D- prunin synthase: synthase: aspartate OO69_RS34555 ribonucleotide- phosphoribosylamine- OO69_RS17125 hydrogen sulfide phosphate carbamate hydrogencarbonate rhamnopyranose synthase: XMP 5-(carboxyamino)imidazole dUDP hypoxanthine degradation II glutamyl-L-lysyl- D-alanyl-D-alanine OO69_RS44275 OO69_RS24570 transaminase: diphosphate reductase: -glycine ligase: purD pyruvate acquisition cyanase: a metal a metal carA carB ribonucleotide mutase: purE phosphoribosyltransferase: hpt sulfite methanesulfonate RS06435 3-deoxy-7- isochorismate 3-(4- OO69_RS29770 nucleoside- OO69_RS19920 a (2E)-hexadec- cynS cation cation adenylo-succinate glutamine- glyphosate hydroxyphenyl) OO69_RS19925 stearate glutathioselenol a phosphate UDP-N-acetyl-α-D- a [prokaryotic a [TusE sulfur DNA containing 46 phosphoheptulonate asp diphosphate kinase: ndk 2-enoyl-[acp] methanesulfonate 34 a [protein]- a DNA methyl a guanine α carbamoyl hydrolyzing GMP CAIR GAR octaheme sulfite di-trans,octa-cis- a uridine in tRNA H O an N-acylated- a (1->4)- -D-glucan N-ethylglycine L(or D)-O- squalene isochorismatase: pyruvate monoester muramoyl-L-alanyl-γ-D- ubiquitin-like protein] carrier protein]-S diphosphate 2 a base with lesion a tRNA precursor sarcosine ser synthase class II: asp adenylosuccinate GMP enoyl-ACP long-chain fatty reductase: monooxygenase: bifunctional a [protein]-L-lysine L-cysteine phosphotriester ATP D-amino acid in tRNA IMP phosphoserine OO69_RS24555 phosphate synthase: guaA dUTP dCDP undecaprenyl phosphate C-terminal L-glutamate -sulfanylcysteine a tRNA precursor tRNA 1,4-alpha-glucan squalene OO69_RS32410 lyase: OO69_RS13130 RNase H/acid glycine CO glutamyl-L-lysyl-D-alanine threonine/serine a metal a metal 3-deoxy- phosphoribosylglycinamide reductase acid--CoA ligase: OO69_RS17135 2 CTP branching bifunctional phosphoserine synthase RS47720 (2S,3S)-2,3- phosphoribosylaminoimidazolesuccinocarboxamide nucleoside triphosphate nucleoside- oxidase cyanate (guanosine(46)-N7) cation OO69_RS27485 formyltransferase: guanine and guanosine salvage FabI: fabI OO69_RS24840 phosphatase: methylated-DNA-- G/U mismatch- glycine phosphatase dehydratase: cation D-arabino- dihydroxy-2,3- GMP diphosphate kinase: ndk Amine and Polyamine Biosynthesis sulfite ThiO: thiO inorganic -methyltransferase enzyme: glgB metallophosphatase/ HpnC: aspartate synthase: OO69_RS35945 pyrophosphohydrolase: hydrogen sulfide OO69_RS19005 phospho-N- Pup--protein tRNA 2- specific DNA D-aminoacylase: ribonuclease D: oxidase OO69_RS13530 heptulosonate dihydrobenzoate adenylosuccinate OO69_RS09945 [+ 17 isozymes] DsbA family hydrogen selenide [protein]-cysteine S- CCA tRNA diphosphatase: TrmB: trmB 1,4-alpha-glucan glycine oxidase 5'-nucleotidase: SerB: serB hpnC carbamoyltransferase OO69_RS31955 dCTP a palmitoyl-[acp] acetylmuramoyl- ligase: pafA thiouridine(34) OO69_RS36570 OO69_RS35620 an N 7 - ThiO: thiO 7-phosphate lyase: oxidoreductase: [+ 3 isozymes] methyltransferase: nucleotidyltransferase: OO69_RS41540 glycosylase: branching ThiO: thiO OO69_RS36155 L-serine presqualene 2,3-dihydro-2,3- catalytic subunit: guanylate dUTP diphosphatase: dut FGAR ectoine biosynthesis stearoyl-CoA phosphate (aminomethyl) pentapeptide- synthase D-aminoacylase: methylguanine 46 serine a metal a metal 3-dehydroquinate OO69_RS06190 SAICAR guanosine OO69_RS26065 glyoxylate Secondary Metabolite Degradation OO69_RS03365 OO69_RS39385 mug enzyme: glgB ammonia-lyase: diphosphate RS50315 dihydroxybenzoate OO69_RS21145 kinase: gmk spermidine biosynthesis III putrescine a [DsbB protein] a [DsbA protein] phosphonate transferase: MnmA: mnmA [+ 2 isozymes] OO69_RS43355 in tRNA inosine cation cation synthase: dUMP purine-nucleoside an electron- an intra- [+ 3 isozymes] a (1,6)-α-D-glucosyl- OO69_RS23945 dehydrogenase: adenylosuccinate phosphoribosylformylglycinamidine biosynthesis I carrying a with reduced L- OO69_RS32570 N6-([prokaryotic OO69_RS21110 phosphorylase: transfer quinol protein disulfide a DNA containing a nucleoside 5'- (1,4)-α-glucan methylamine ethylamine glyoxylate pyruvate OO69_RS24575 AMP lyase: OO69_RS27485 FAD-dependent thymidylate synthase: purS purQ purL asp disulfide bond cysteine residues Fatty Acid and Lipid Degradation anhydromuropeptides recycling I ubiquitin-like protein]- a tRNA a modified a tRNA glyoxylate N-carbamoyl- acyl-CoA hydrolysis D-glucarate N-acetylglucosamine 34 monophosphate OO69_RS10700 arg SAM a 2-thiouridine a [TusE sulfur carrier + an apurinic/ 3-dehydroquinate 2,3- GDP adenylosuccinate synthase: OO69_RS35315 aspartate kinase: arg undecaprenyl-diphospho-N γ-L-glutamyl)- a [protein]-S- containing a phosphate H nucleobase a carboxylate a metal a metal L-aspartate guanine palmitate GlcNAc-1,6- degradation II degradation I UMP in tRNA protein]-L-cysteine [DNA] apyrimidinic site a D-amino acid RS03520 synthase: dihydroxybenzoate FGAM γ [protein]-L-lysine methyl-L-cysteine 3' CCA end cation cation adenylate kinase: lyase: OO69_RS06190 dTMP OO69_RS34720 a 2,3,4-saturated oleate β-oxidation anhMurNAc- N-acetyl-D- -acetylmuramoyl-L-alanyl- - OO69_RS44270 dihydroorotase: fatty acid β-oxidation I (generic) OO69_RS09405 L-aspartyl- long-chain fatty fatty acyl CoA γ D-glucarate D-glutamyl-L-lysyl- D-alanine dTMP kinase: phosphoribosylformylglycinamidine acyl-CoA 6 37 L-Ala- -D-Glu- glucosamine OO69_RS21150 nucleoside- vitamin B12- AICAR hypoxanthine 4-phosphate acid--CoA ligase: Pentose Phosphate Pathways N -L-threonylcarbamoyladenosine glucarate 3-dehydroquinate OO69_RS42540 cyclo-ligase: OO69_RS36035 agmatine DAP-D-Ala 6-phosphate ADP diphosphate dependent phosphoribosyltransferase: hpt OO69_RS24840 thioesterase II: -modified tRNA biosynthesis oleate a (3Z)-alk-3- dehydratase: N-acetylglucosamine- a metal a metal bifunctional an (S-diacyl-sn- luteolin 7-O-[β-D- N-acetyl-D- 37 RS29455 (S)-dihydroorotate dTDP aspartate- agmatine dAdoMet OO69_RS00545 6-phosphate ditrans,octacis-undecaprenyldiphospho- an L-1- 3-aci- an N-modified guanine hydrogen a double 7,8-dihydro- phosphoenol cation 3-dehydroquinate kinase: ndk ribonucleotide agmatinase: [+ 17 isozymes] pentose phosphate pathway long-chain fatty enoyl-CoA OO69_RS04200 glyceryl)-L-cysteinyl- glutathione glycerophosphoserine β a peptide with a galactosamine [DNA] A(H2) 3',5'-ADP cation phosphoribosylaminoimidazolecarboxamide AIR deacetylase: nagA N-acetyl-(N-acetylglucosaminyl) phosphatidylethanolamine nitropropanoate hypoglycin A glucosyluronate-(1,2)- - in tRNA Phe peroxide stranded DNA 8-oxoguanine repressor LexA pyruvate dehydratase: ribonucleotide- reductase: semialdehyde [+ 5 isozymes] D-glucosamine leader sequence aminoacyl-[tRNA] phenylethanol biosynthesis formyltransferase/IMP cyclohydrolase: purH nucleoside- GMP speB a 2,3,4-saturated thr acid--CoA ligase: ∆ 3 -cis-∆ 2 -trans- glucarate muramoyl-L-alanyl-γ-D-isoglutaminyl- D-aspartate [apolipoprotein] D-glucosiduronate]-4'- 6-phosphate tRNA bifunctional DNA gyrase 8-oxoguanine 3'(2'),5'- pyruvate quinone- diphosphate OO69_RS41840 dehydrogenase: palmitoyl-CoA D-glucopyranose 6-phosphate transcriptional OO69_RS44320 diphosphate kinase: ndk polyamine fatty acid threonylcarbamoyl-AMP OO69_RS24840 enoyl-CoA N-acetyl-β-D- L-alanyl-γ-D- dehydratase: L-lysyl-D-alanyl-D-alanine O-β-D-glucosiduronate (guanosine(37)-N1) DNA primase/ subunit B: deaminase: bisphosphate kinase: pyk dependent reductase: GTP FAICAR superpathway of pyrimidine OO69_RS34725 putrescine 6-phosphate nitronate glycerophosphodiester catalase/ repressor a metal a metal type II 3- ribonucleotide- dTTP aminopropyltransferase: synthase: OO69_RS37485 [+ 17 isozymes] isomerase: glucosamine-1,6- glutamyl-meso-2,6- OO69_RS40595 apolipoprotein N-acetylglucosamine- -methyltransferase polymerase: OO69_RS12305 OO69_RS06795 nucleotidase pyruvate RS27285 dihydroorotate OO69_RS19920 aspartate- 5-dehydro-4- gamma- signal peptidyl-tRNA peroxidase cation cation dehydroquinate phe diphosphate nucleobases salvage OO69_RS34385 glucose-6- acyltransferase: monooxygenase: phosphodiesterase: TrmD: trmD OO69_RS23180 LexA: lexA dehydrogenase: bifunctional threonylcarbamoyl-AMP OO69_RS35630 anhydro-N-acetyl- diaminopimeloyl- deoxy-D-glucarate glutamyltransferase: beta- peptidase I: lepB hydrolase: 6-phosphate an N 1 - DNA: 8-oxoguanine CysQ: kinase: pyk OO69_RS19925 adenine and adenosine salvage III semialdehyde oleoyl-CoA D-aspartate ligase: OO69_RS40540 OO69_RS22770 HPI: katG dehydratase: aroQ reductase: uracil phosphate synthase: OO69_RS25115 β-D-muramate D-alanine α-D-glucosamine OO69_RS06450 37 [+ 7 isozymes] gyrA gyrB deaminase: cleaved OO69_RS15015 OO69_RS21170 phosphoribosylaminoimidazolecarboxamide N 1 -(3- OO69_RS08195 glucuronidase: [+ 4 isozymes] OO69_RS35460 deacetylase: nagA methylguanine a 2'- pyruvate vitamin B12- OO69_RS19920 dehydrogenase: cadaverine dehydrogenase: (L-threonylcarbamoyl)adenylate a (2E)-2- 5-dehydro-4- OO69_RS22450 [+ 4 isozymes] [+ 6 isozymes] a negatively repressor LexA uracil beta-N- 6-phosphate [+ 2 isozymes] Phe OO69_RS02635 a metal a metal 3-dehydroshikimate aromatic amino PRPP formyltransferase/IMP cyclohydrolase: purH OO69_RS33340 aminopropyl) biosynthesis acyl-CoA/acyl-ACP deoxyglucarate [+ 2 isozymes] uidA [+ 2 isozymes] in tRNA deoxyribonucleoside orotate dependent OO69_RS19925 phosphoribosyltransferase: upp OO69_RS39615 enoyl-CoA 3-hydroxyacyl- acetylhexosaminidase: supercoiled DNA AMP RS35465 acid lyase: superpathway of pyrimidine deoxyribonucleoside salvage agmatine tRNA (adenosine(37)-N6)- dehydrogenase: glucosamine- D-galactosamine 5'-monophosphate A H O urate cation cation ribonucleotide adenine L-aspartate 4- a 2,3,4- dehydratase: an N-acyl-(S-diacyl- [unspecified 2 shikimate bifunctional pyr operon spermidine glucose-6- enoyl-CoA CoA epimerase: OO69_RS40800 L-alanyl-γ-D- 6-phosphate ditrans,octacis-undecaprenyldiphospho- a 2-acyl-1-lyso- sn-glycerol acetate OO69_RS32105 IMP threonylcarbamoyltransferase OO69_RS24980 a 2,3,4-saturated long-chain fattyacyl-CoA/acyl-ACP OO69_RS40590 3-oxopropanoate nitrite β luteolin 7-O-β- a leader sequence a peptide 6-phosphate primary-amine orotate reductase: 2'-deoxycytidine purine-nucleoside transcriptional regulator/uracil semialdehyde biosynthesis I lys phosphate hydratase: OO69_RS35630 saturated (3R)-3- beta-N- N-acetyl-(N-acetylglucosaminyl)muramoyl- phosphatidylethanolamine sn-glyceryl)-L- degradation hypoglycin B ser -D-glucuronate an N-modified an uncharged dehydrogenase: xanthine and complex: tsaE tsaB tsaD [+ 18 isozymes] fatty acid acid--CoA ligase:dehydrogenase: glutamyl-meso- deaminase: L-cysteinylglycine 3-phosphate D-diglucuronide oxidase: phosphoribosyltransferase: OO69_RS41840 dGDP phosphorylase: phosphoribosyltransferase diaminobutyrate- lysine dehydrogenase: OO69_RS35630 hydroxyacyl-CoA acetylhexosaminidase: 5-dehydro-4- L-alanyl-γ-D-isoglutaminyl-N-(β-D- cysteinyl-[lipoprotein] products] amino acid tRNA a metal OO69_RS39650 xanthosine salvage (2E,9Z)- OO69_RS22240OO69_RS00315 diaminopimelate nagB RS44315 a metal OO69_RS08190 OO69_RS34400 OO69_RS10700 decarboxylase OO69_RS25610 an N 6 -L-threonylcarbamoyladenine 37 in tRNA deoxyglucarate [+ 2 isozymes] 2-phenylethylamine nucleoside PyrR: pyrR -2-oxoglutarate SAM a 2,3,4- OO69_RS17950 asparatyl)-L-lysyl-D-alanyl-D-alanine cation cation adenosine spermidine octadecenoyl-CoA [+ 17 isozymes][+ 18 isozymes] dehydratase: F6P dADP nucleoside- deaminase: UMP transaminase: ectB DesA: desA 6-phospho a 2,3,4-saturated saturated (3S)-3- phenylacetaldehyde xanthosine cadaverine enoyl-CoA 1,6-anhydro-N- OO69_RS25865 shikimate orotidine 5'- diphosphate OO69_RS22120 D-glucono- fatty acyl CoA dCMP hydroxyacyl-CoA acetyl-β-muramate β α a 2'- a peptidoglycan an N-terminal- 37 adenosine deaminase: UMP kinase: L-2,4- 1,5-lactone hydratase: -D-ManNAc-(1->4)- -D- a 2-oxo a guanine a supercoiled (5R)-5-benzyl- an organic phosphate nucleoside- kinase: ndk [+ 5 isozymes] purine-nucleoside 3-hydroxyacyl-CoA 2,5- β-D-glucuronide CDP-glycerol 3-methylbutanoate hop-22(29)-ene SAM glycerophosphoglycerol deoxyribonucleoside L-methionyl-L- O-ureido-L- a dipeptide acetylxylan 3-cyanopyridine a metal a metal shikimate kinase: pyrimidine ribonucleosides salvage I (d)CMP kinase: OO69_RS40575 OO69_RS23035 diaminobutanoate OO69_RS35630 anhydro-N- GlcNAc-PP-undecaprenol carboxylate [DNA] dimer (generic) asp in tRNA duplex DNA hydantoin cys hydroperoxide RS12485 diphosphate phosphorylase: 6-phosphogluconolactonase: dioxopentanoate and D-glucuronate 5'-triphosphate cysteinyl-[protein] homoserine UvrD-helicase Asp/Glu/hydantoin membrane thioredoxin- nitrile cation cation orotidine-5'- [+ 5 isozymes] TCA cycle TCA cycle IV (2-oxoglutarate decarboxylase) dehydrogenase: acetylmuramic D-galacturonate tRNA OO69_RS21105 dGTP 2'-deoxyuridine OO69_RS42100 UDP OO69_RS10700 diaminobutyrate pgl (S)-3-hydroxy-(9Z) cystathionine phosphate kinase: ndk cytidine putrescine dAdoMet coenzyme A OO69_RS35630 degradation I degradation (guanosine(37)-N1) domain-containing racemase: dipeptidase: acetylxylan dependent hydratase xanthine acetyltransferase: -octadecenoyl-CoA acid kinase: a β-D- 2-oxoacid:ferredoxin acetate- glycerophosphodiester endolytic shikimate 3- 2-phenylethanol dCDP nucleoside- D-gluconate bifunctional glycosyltransferase adenosyl- DNA polymerase -methyltransferase protein: OO69_RS11095 OO69_RS15080 beta-synthase: thiol subunit decarboxylase: inosine citrate synthase/ a 2,3,4-saturated a 2,3,4-saturated OO69_RS18075 aldehydo-D- oxidoreductase -CoA transglycosylase type I methionyl esterase: a metal a metal phosphate dATP thymidine kinase: diphosphate kinase: ndk ectA oxaloacetate 3-hydroxyacyl-CoA acetyl-CoA C- glucuronoside family 2 protein/CDP- hopene phosphodiesterase: argininosuccinate TrmD: trmD OO69_RS40755 OO69_RS32065 peroxidase: alpha: nthA pyrF uridine kinase: nucleoside nucleoside- 6-phosphate N-acetyl-D- galacturonate beta- III subunit alpha: MltG: mltG an N 1 - Asp/Glu/hydantoin [+ 3 isozymes] OO69_RS02630 RS44215 OO69_RS30040 (2S)-4-acetamido- spermidine methylcitrate synthase: dehydrogenase: fatty acyl CoA 3-oxoacyl-CoA 2-oxoglutarate glycerol:glycerophosphate subunit beta: ligase: acs OO69_RS25415 aminopeptidase: synthase: argG cation cation acyltransferase: transferase 37 a proteinogenic bcp 3-phosphoshikimate 1- OO69_RS10610 deaminase: diphosphate purine-nucleoside UTP synthase: decarboxylating 6- muramate 6- glucuronidase: OO69_RS22595 OO69_RS42260 map methylguanine [+ 5 isozymes] racemase: lanthionine nicotinamide UMP 2-aminobutanoate OO69_RS30105 OO69_RS35630 OO69_RS35625 glycerophosphotransferase: HpnH: hpnH [+ 6 isozymes] [+ 3 isozymes] a single carboxyvinyltransferase: uridine kinase: OO69_RS22120 thymidine kinase: ndk CMP OO69_RS20180 phosphogluconate phosphate uidA [+ 13 isozymes] in tRNA OO69_RS47715 amino acid an alcohol adenine and dUMP phosphorylase: CTP synthase: citrate synthase: 3-oxo-(9Z)- OO69_RS35640 [+ 2 isozymes] stranded DNA (5S)-5-benzyl- aroA UMP kinase: OO69_RS25370 [+ 5 isozymes] phosphorylation ectoine synthase: dehydrogenase: gnd N-acetylmuramic D-tagaturonate D-glucopyranuronate 3-methylbutanoyl- acetate xylan adenosine salvage I dCTP OO69_RS10700 OO69_RS42000 XMP [+ 3 isozymes] OO69_RS47295 diphosphate GlcNAc-1,6- glycine glycine OO69_RS23035 thymidine kinase: OO69_RS26080 octadecenoyl-CoA acid 6- [+ 3 isozymes] a reduced AMP CoA a lipid II canavaninosuccinate hydantoin RS40890 3-phosphoshikimate 1- [+ 3 isozymes] an acyl-CoA CO H + adenosyl hopane glycerol sn-glycerol betaine betaine CTP synthase: CMP 2 ferredoxin [iron- met anhydro-MurNAc- an N-terminal L- CMP uridine OO69_RS30040 malate dehydrogenase: acetyl-CoA C- testosterone degradation (anaerobic) phosphate 3-phosphate [DNA] carboxyvinyltransferase: UDP hypoxanthine OO69_RS16945 (d)CMP kinase: D-ribulose sulfur] cluster pentapeptide met cysteinyl-[protein] adenosine ectoine spermidine (S)-malate OO69_RS10040 citrate acyltransferase: etherase: murQ D-galactonate degradation CMP Gro-P-ManNAc-GlcNAc- aroA uridine kinase: OO69_RS42100 5-phosphate aldehydo-D- 5-enolpyruvoyl- nucleoside- purine-nucleoside CTP OO69_RS35625 acetyl-CoA N-acetyl-D- D-altronate PP-undecaprenol CDP testosterone + + diphosphate OO69_RS10610 hypoxanthine glucosamine glucuronate Na RS42510 Na shikimate 3- phosphorylase: Secondary Metabolite Biosynthesis ribulose- ribose-5- class II fumarate D-galactonate kinase: ndk uridine kinase: dTMP phosphoribosyltransferase: hpt nucleoside- (7Z)-hexadecenoyl-CoA 3-oxosteroid 1- 6-phosphate altronate phosphate gln OO69_RS10700 hydratase: OO69_RS43860 UDP-N-acetyl- undecaprenyldiphospho- a 5'-phospho- (3R,6R)-1,3,4,6- OO69_RS25370 phosphate 3- phosphate aconitate hydratase dehydratase: a pentaglycine cross- 6 6 sn-glycero-3- (S)-1-pyrroline- long chain chorismate adenine dTMP kinase: diphosphate dehydrogenase: N-acetylglucosamine- galactonate α a protein with N ,N -dimethyl- succinate pimeloyl-CoA carbamoyl (S)-2- an [RNA]- ribonucleoside- tetrachlorocyclohexa- an aliphatic amine propionitrile UTP streptorubin B biosynthesis epimerase: isomerase: fumarate hydratase: AcnA: acnA acyl-CoA/acyl-ACP OO69_RS07875 -D-glucosamine N-acetylmuramoyl-L- bridge of peptidoglycan phosphoethanolamine ala L-ornithine glu GTP his 5-carboxylate polyphosphate a protein synthase: UMP OO69_RS42540 kinase: ndk preQ biosynthesis geosmin biosynthesis OO69_RS22245 6-phosphate dehydratase: γ LAXTG motif L-arginine phosphate aminobutanoate 3'-hydroxyl L-glutamate + + IMP methylerythritol phosphate pathway I actinorhodin biosynthesis 0 rpe OO69_RS40035 OO69_RS43875 dehydrogenase: alanyl- -D-glutamyl-meso [RNA] 1,4-diene copper amine polyphosphate nitrile Na RS13220 Na deacetylase: nagA 2-dehydro- D-fructuronate haloalkane aroC CTP synthase: adenine CTP OO69_RS24980 dgoD -2,6-diaminopimeloyl- adenylate/guanylate oxidase: L-histidine N(alpha) gamma- kinase 2: ppk2 hydratase dTDP fumarate 1-dehydrotestosterone 3-deoxy-D- lysin: OO69_RS42000 phosphoribosyltransferase: acetyl-CoA D-glyceraldehyde (2E,6E)-farnesyl cis-aconitate D-glucosamine galactonate ADP-forming succinate- glycerophosphodiester dehalogenase: cyclase domain- OO69_RS17015 -methyltransferase: semialdehyde subunit pyruvate D-xylulose D-ribose 5- [+ 18 isozymes] gluconate D-alanyl-D-alanine class E sortase: N(G),N(G)-dimethylarginine 8-amino-7- ornithine glutamate-- polyphosphate OO69_RS21890 chorismate OO69_RS20995 nucleoside- malonyl-CoA aconitate hydratase 6-phosphate -CoA ligase: sucC sucD phosphodiesterase: RNA ligase (ATP) OO69_RS38555 egtD CTP synthase: 3-phosphate GTP diphosphate 5-phosphate phosphate (2E,7Z)- dehydratase: OO69_RS39180 dimethylaminohydrolase: oxononanoate carbamoyltransferase: containing protein: primary-amine dehydrogenase: kinase 2: ppk2 alpha: nthA ketoacyl-ACP germacradienol/ succinate dehydrogenase/ AcnA: acnA 2-dehydro-3- OO69_RS22770 cysteine ligase: : OO69_RS28360 (1S,4R)-2,4,5- fluoride CrcB fluoride diphosphate phosphoglucosamine dgoD undecaprenyldiphospho- [+ 4 isozymes] ADP-forming succinate- OO69_RS10755 pruA long chain OO69_RS16945 synthase III: GTP geosmin fumarate reductase hexadecenoyl-CoA deoxygluconokinase: ddaH synthase: argF OO69_RS15075 trichloro-2,5- oxidase: hercynine a peptide propionamide AMP kinase: ndk 1-deoxy-D- a 3,5,7,9,11,13,15- muramoylpentapeptide beta-N- -CoA ligase: sucD sucC [+ 6 isozymes] cyclic-GMP polyphosphate OO69_RS12635 cyclohydrolase transketolase: iron-sulfur subunit: enoyl-CoA mutase: OO69_RS09465 OO69_RS07345 2-dehydro-3-deoxy- OO69_RS00075 [+ 2 isozymes] cyclohexadiene-1-diol OO69_RS08190 synthase: ∆ 1 glu CTP xylulose-5- hepta-oxo- 7,8- -dihydrotestosterone acetylglucosaminyltransferase: a protein with LAXT dTTP [+ 2 isozymes] I FolE: folE (1E,4S,5E,7R)-OO69_RS16935 OO69_RS26830 OO69_RS04315 hydratase: α-D-glucosamine D-galactonate a peptide with an an aldehyde dihydroneopterin murG carboxyl end attached RNA fluoride phosphate hexadecanoyl-[PKS-acp] [+ 4 isozymes] 1-phosphate KDGP dimethylamine CrcB fluoride 3'-triphosphate germacra-1(10) [+ 3 isozymes] OO69_RS35630 N-terminal glycine L-citrulline ADP succinyl-CoA ethanolamine sn-glycerol (8S)-8-amino-7- L-citrulline γ synthase: aldo/keto succinate D-threo-isocitrate to a pentaglycine cross- phosphate coenzyme A -L-glutamyl-(S)- an acetoacetyl-[acp] ,5-dien-11-ol (S)-3-hydroxy-(7Z) 3-oxosteroid 1- bifunctional UDP-N- lipid II (meso 3-phosphate oxononanoate OO69_RS35685 reductase: 6-carboxytetrahydropterin D-sedoheptulose D-glyceraldehyde NADP-dependent bifunctional UDP bridge of peptidoglycan 2-aminobutanoate germacradienol/ -hexadecenoyl-CoA dehydrogenase: acetylglucosamine 2-dehydro-3-deoxy- diaminopimelate containing) OO69_RS22925 synthase: OO69_RS39740 7-phosphate 3-phosphate isocitrate dehydrogenase: 4-hydroxy-2- Amino Acid Biosynthesis 3-oxoacyl- 1-deoxy-D- geosmin succinate-semialdehyde 1,17- OO69_RS22245 Co 2+ CbiQ Co 2+ [+ 23 isozymes] OO69_RS04905 3-hydroxyacyl-CoA diphosphorylase/ D-galactonate ACP xylulose-5- 6-carboxy-5,6,7,8- synthase: dehydrogenase (NADP(+) dihydroxyandrostan- oxoglutarate 9-hydroxy-3,5,7,11,13,15- dehydrogenase: glucosamine-1- 6-phosphate 6 5-(methylsulfanyl) 6-O-cis-methoxy- phosphate tetrahydropterin transaldolase: tal ): OO69_RS09775 aldolase/2- N -(3-methylbut- (1S,2R)-1- a [DNA]-3'- a [protein] N- a (2E,4Z)-2,4- superpathway of L- reductase hexaoxohexadecanoyl- OO69_RS16935 OO69_RS35630 3-one androsta-1- phosphate N- a sulfurated [CysO sulfur- glycyl-glycine glutathione a homogalacturonan futalosine protoheme a [protein] (L-serine/L- oxaloacetate n-butyronitrile L-histidine biosynthesis L-lysine biosynthesis I superpathway of branched chain amino acid biosynthesis L-tryptophan biosynthesis L-proline L-methionine biosynthesis III L-cysteine biosynthesis I (8S,9S,10S)- transaldolase: tal dehydro-3-deoxy- a sulfurated [sulfur carrier] 2-en-1-yl)- ser C-(indol-3- terminal-formyl- -2,3-dioxopentyl mycolyl-trehalose cys isoleucine biosynthesis I L-isoleucine FabG: fabG synthase: ene-3,17-dione [sulfur carrier] carrier protein] hydroxyl threonine) phosphate ATP dienoyl-CoA 2+ 2+ [PKS-acp] 3-oxo-(7Z)- acetyltransferase 37 1-phosphate 6-phosphate Co Co biosynthesis I biosynthesis IV OO69_RS18400 8,10-dimethyl- phosphogluconate adenosine in tRNA yl)glycerol L-methionine protein citrate synthase/ NADPH- nitrile RS06910 3-oxoacyl- succinate semialdehyde GlmU: glmU trehalose- cystathionine Mg 2+ Mg 2+ (from L-glutamate) 1-octalin D-erythrose 2-oxoglutarate hexadecenoyl-CoA aldolase: 3-phosphate adenylate/guanylate methylcitrate dependent 2,4- hydratase oxaloacetate PRPP pyruvate L-arginine biosynthesis I (via L-ornithine) F6P α pectate lyase: futalosine phosphatase: acireductone asp thr gln L-homoserine ser [acyl-carrier- 4-phosphate acetyl-CoA C- N-acetyl- -D- D-glyceraldehyde gamma- exodeoxyribonuclease deferrochelatase/ cyclase domain- synthase: dienoyl-CoA phosphatase: beta-synthase: subunit aspartate chorismate propanoate 1-deoxy-D-xylulose 7-carboxy-7- germacradienol/ 17-hydroxyandrostan- OO69_RS30620 pyruvate tRNA (N6-isopentenyl adenylyltransferase/ OO69_RS00915 hydrolase: peptide OO69_RS40070 synthase: mtnC acetolactate glu protein] acyltransferase: glucosamine 3-phosphate glutamyltransferase: tryptophan III: xth peroxidase EfeB: efeB containing protein: OO69_RS30105 reductase: otsB OO69_RS32065 alpha: nthA ATP long-chain fatty a (3'-hydroxy-2'- deazaguanine geosmin transketolase: 1,3-dione sulfurtransferase deformylase: 1,2-dihydroxy-5- trehalose- 2+ 2+ transaminase: aspartate kinase: threonine/serine homoserine O- serine reductase: 5-phosphate 1-phosphate [+ 4 isozymes] adenosine(37)-C2)- OO69_RS08195 pectate lyase: synthase: trpB OO69_RS15400 [+ 4 isozymes] [+ 5 isozymes] Co Co phosphoribosyltransferase: synthase: glutamate (3''-oxobutanoyl) synthase: OO69_RS35625 exodeoxyribonuclease OO69_RS10755 OO69_RS02680 CorA OO69_RS29770 OO69_RS34720 glu acid--CoA ligase: 1-deoxy-D-xylulose- OO69_RS26830 methylthiotransferase MoeZ: moeZ OO69_RS25940 OO69_RS04045 a [protein] Ser/Thr citrate synthase 2: (methylsulfanyl) cis-methoxy- ser butyramide 2+ 2+ dehydratase: anthranilate synthase 5-kinase: acetyltransferase: acetyltransferase: fabG multifunctional oxoglutarate bifunctional UDP-N- pyruvate [+ 2 isozymes] OO69_RS32830 III: xth cyclic-AMP a (2E)-2- Mg Mg OO69_RS21410 OO69_RS27825 OO69_RS24840 phenyl)-3,5- OO69_RS16935 [+ 4 isozymes] MiaB: miaB OO69_RS43690 pent-1-en-3-one mono-mycolate asp L-aspartyl-4-phosphate OO69_RS13530 component I: OO69_RS40340 OO69_RS08570 OO69_RS36315 a (3R)-3- 5-phosphate (5Z)-tetradecenoyl-CoA [+ 3 isozymes] enoyl-CoA [+ 2 isozymes] amino-acid N- γ-L-glutamyl dioxohexanethioate- decarboxylase/oxoglutarate acetylglucosamine dehypoxanthine (2S,3S)-2- [+ 17 isozymes] hydroxybutanoyl- reductoisomerase: D-glyceraldehyde a [CysO sulfur- Fe 2+ protoporphyrin IX 1-(5-phospho-β-D-ribosyl)-ATP threonine OO69_RS32800 O-acetyl-L- (-)-geosmin dehydrogenase thiamine androstan- diphosphorylase/ an unsulfurated γ an unsaturated D-glyceraldehyde a 2'- futalosine methylcitrate acetyltransferase: 5-phosphate propanoyl-CoA [PKS-acp] preQ 3-phosphate acyl-CoA/acyl-ACP 6 -L-glutamyl- a homogalacturonan a [DNA]-3'- hypoxanthine 2+ 2+ O-acetyl-L-serine [acp] OO69_RS35025 0 D-glucarate L-idonate N -(3-methylbut-2-en- carrier protein]- L-cysteinylglycine pectate 3-phosphate trp Co Co aspartate kinase: aspartate- ammonia-lyase: (S)-2-acetolactate OO69_RS41380 homoserine hydrogen sulfide hydrogen sulfide pyrophosphate-binding 1,3,17-trione glucosamine-1- [sulfur carrier] deoxyribonucleoside an N-terminal L- RS19515 dehydrogenase: 5'-deoxyadenosine 1-yl)-2-(methylsulfanyl) an unsulfurated thiocarboxylate glycylglycine hydroxyl formate Mg 2+ Mg 2+ OO69_RS34720 phosphoribosyl-ATP semialdehyde OO69_RS36720 glutamate-5- 2-oxoacid:ferredoxin subunit/dihydrolipoyllysine- degradation I degradation met oligosaccharide 5'-monophosphate methionyl-[protein] phosphate N- 37 [sulfur carrier] diphosphatase: ketol-acid bifunctional anthranilate PRPP semialdehyde MEP OO69_RS00315 phospholipases adenosine in tRNA dehydrogenase: (2Z)-2-aminobut- oxidoreductase residue succinyltransferase acetyltransferase OO69_RS21405 reductoisomerase: glutamate N- dehydrogenase: O-acetylhomoserine cysteine synthase: 4-(3'-acetyl-5'- [+ 18 isozymes] L-idonate L-aspartyl- OO69_RS34725 subunit beta: subunit: OO69_RS20165 GlmU: glmU D-glucarate 2-enoate sulfhydrylase: 2-C-methyl-D- a 1,2-diacyl- 2+ 2+ 4-phosphate OO69_RS01790 acetyltransferase/ anthranilate OO69_RS40350 OO69_RS41020 a (2E)-but- hydroxy-4'-oxo-1',4'- myo-inositol (2E,5Z)- glucarate L-idonate 5- Co Co β aspartate- OO69_RS22595 UDP-N-acetyl- α 3-oxo-23,24- 6-O-trans-keto- CorA 1-(5-phospho- -D-ribosyl)-AMP OO69_RS08575 erythritol 4-phosphate echinomycin and triostin A biosynthesis a phosphatidylcholine sn-glycerol an (S)-2- + an insertion sequence a (2E,4E)-2,4- 2+ 2+ ketol-acid amino-acid phosphoribosyltransferase: trpD [+ 2 isozymes] 2-enoyl-[acp] dihydronapthalen-2'- biosynthesis tetradecenoyl-CoA dehydratase: dehydrogenase: pyruvate hydrogen selenide isobutanoate 2-methylbutanoate O-succinyl-L- an N -methyl ammonium NAD H O histidinol phenylacetyl-CoA squalene Mg Mg L-glutamate-5- α cys a PII protein 2 bisnorchol-4- mycolyl-trehalose a protein aspartate- semialdehyde acetyltransferase cytidylyltransferase: yl)-3-oxobutanoate- 3-phosphate -D-glucosamine OO69_RS22880 O-acetyl-L-serine homoserine halocarboxylate L-amino acid element IS30 dienoyl-CoA reductoisomerase: semialdehyde 2-oxobutanoate enoyl-ACP OO69_RS04200 UTP histidinol en-22-oyl-CoA 6-phosphate semialdehyde phosphoribosyl-AMP dehydrogenase: OO69_RS15810 D-glucopyranose UDP-N-acetylglucosamine transposase: phenylacetate- NADPH- squalene- ilvC ArgJ: argJ [PKS-acp] ∆ 3 -cis-∆ 2 -trans- enoyl-CoA L-idonate 5- 3-oxosteroid 1- trehalose- cyclohydrolase: hisI OO69_RS33340 L-homocysteine reductase 6-phosphate glucarate dehydrogenase: hisD CoA oxygenase/ dependent 2,4- -hopene dehydrogenase: 2-iminobutanoate N-(5-phosphoribosyl)-anthranilate acetolactate cys 4-(cytidine 5'- ATP a 1-acyl-sn 1-carboxyvinyltransferase: OO69_RS02355 endopeptidase 2+ 2+ (2R)-2,3- FabI: fabI quinoxaline- inositol-3- enoyl-CoA hydratase: dehydrogenase: pyruvate, phosphate acetate- HAD family nitrite dehydrogenase: phosphatase: Mg MgtA Mg 1-(5-phospho-β-D-ribosyl)- N-acetyl-L- diphospho)-2-C- a phosphatidylcholine dehydratase: cysteine synthase: acetate--CoA cystathionine N-methyl-L- [protein-PII] [+ 11 isozymes] histidinol reductase: dienoyl-CoA cyclase: OO69_RS34725 L-aspartate 4- dihydroxy-3- synthase: 2-carboxylate phosphate isomerase: OO69_RS35630 -glycero-3- OO69_RS36150 OO69_RS28490 dikinase: OO69_RS25350 -CoA hydrolase: reductase: OO69_RS22245 otsB La: lon glutamate bifunctional 1-(5- OO69_RS40595 OO69_RS41020 ligase: acs an insertion dehydrogenase: hisD paaA paaB reductase: shc 5-[(5-phosphoribosylamino) semialdehyde OO69_RS27825 methionine methyl-D-erythritol phosphocholine [+ 2 isozymes] 5-dehydro-4- 5-dehydro- ligase: acs gamma-synthase: tryptophan uridylyltransferase: nirD nirB 3-oxo-23,24- trehalose- aspartate- methylbutanoate a butanoyl-[acp] 4-(3'-acetyl-5'- synthase: OO69_RS18220 pyruvate, phosphate OO69_RS23385 sequence IS30 with methylideneamino]imidazole- phosphoribosyl)-5-((5- (S)-1-pyrroline- synthase: 5-methyltetrahydropteroyltriglutamate- 4-(cytidine 5'- α deoxy-D-glucarate D-gluconate [+ 2 isozymes] OO69_RS36740 oxidase: solA OO69_RS23160 paaC paaJ paaK bisnorchol-1,4- OO69_RS02680 trans-keto- a peptide hop-22(29)-ene semialdehyde dihydroxy-acid acetylglutamate [+ 2 isozymes] OO69_RS39400 (S)-3-hydroxy-(5Z) UDP-N-acetyl- - dikinase: OO69_RS33650 [+ 10 isozymes] his 2-(1,2-epoxy-1,2- a (2E)-2- 4-hydroxy- 5-carboxylate - homocysteine S- diphospho)- hydroxy-4'-oxo-1',4'- integrated transposon 2+ 2+ 4-carboxamide phosphoribosylamino) metH a 2-acyl-sn dihydrophenyl) dien-22-yl-CoA mono-mycolate Mg RS19500 Mg dehydrogenase: dehydratase: kinase: argB (S)-2-aceto-2- dihydronapthalen-2'- Ins(3)P (3E,5Z)-tetradeca- -tetradecenoyl-CoA D-glucosamine- 5-keto-D- (2S)-2- enoyl-CoA bifunctional 1-(5- tetrahydrodipicolinate 2-oxobutanoate methylideneamino)imidazole- pyrroline-5- methyltransferase: metE 2-C-methyl-D- a phosphatidylcholine -glycero-3- isobutanoyl-CoA OO69_RS33340 ilvD hydroxybutanoate methionine 3,5-dienoyl-CoA 3-hydroxyacyl-CoA enolpyruvate gluconate 5- acetate diphosphate methylbutanoyl- diphosphate nitrite acetyl-CoA synthase: dapA N-acetylglutamyl- 4- carboxamide isomerase/ carboxylate [+ 2 isozymes] erythritol kinase: yl)-3-oxobutanoate quinoxaline-2- phosphocholine L-selenocysteine AMP AMP succinate a (2R)-2- formaldehyde a uridylylated phosphoribosyl)-5-((5- synthase: + an L-amino acid acetolactate 3-methyl-2- 2-aceto-2-hydroxy- hydroxylacyl-CoA inositol dehydrogenase: UDP-N- reductase: phosphoenolpyruvate diphosphate H CoA L-cystathionine a halide anion L-aspartate 4- phosphoribosylamino) 4-hydroxy- phosphate phosphoribosylanthranilate reductase: OO69_RS38670 carboxyl adenylate acyl-CoA tartronate AMP hydroxy fatty acid PII protein OO69_RS23790 a 3-oxohexanoyl- dehydrogenase: monophosphatase: OO69_RS35630 acetylmuramate OO69_RS28495 Peptide RS08625 Peptide semialdehyde tetrahydrodipicolinate synthase: oxobutanoate isomerase PriA: priA proC butanoate 2-phospho-4-(cytidine acyl carrier thioesterase II: semialdehyde methylideneamino)imidazole- N-acetyl- OO69_RS43130 OO69_RS14055 phospholipase C, dehydrogenase: synthase: dapA OO69_RS27825 isomeroreductase: [acp] 5'-diphospho)-2-C- protein: OO69_RS00545 3-oxo-(5Z)- homoserine 4- carboxamide isomerase/ gamma-glutamyl- 1-(2-carboxyphenylamino)-1- met (S)-4-(3'-acetyl-5'- phosphocholine- OO69_RS08975 2-hydroxy-3- D-gluconate (2S,4S)-4- [+ 2 isozymes] 2-isopropylmalate branched-chain pro ilvC 3-oxoacyl- methyl-D-erythritol hydroxy-4'-oxo-1',4'- OO69_RS16705 [+ 2 isozymes] [+ 5 isozymes] tetradecenoyl-CoA dehydrogenase: phosphoribosylanthranilate phosphate deoxy-D-ribulose 5-phosphate L-cysteine biosynthesis V (mycobacteria) specific: UDP-N-acetyl- oxopropionate hydroxy-2,3,4,5- (S)-2-aceto-2- synthase: amino acid (R)-2,3-dihydroxy- ACP 2-C-methyl-D- dihydronapthalen-2'- [+ 3 isozymes] (3E,5Z)- acetyl-CoA C- gluconokinase: a nascent peptidoglycan dehypoxanthine a peptide with a uridine 38- a [protein]-L- β-D-glucose OO69_RS37440 isomerase PriA: priA reductase: indole-3-glycerol myo-inositol OO69_RS18045 α reductase: AsbD acyl- 7,8-dihydrofolate + an (R)-2- an (R)-2- S-methyl-L- an L-glutamyl- Peptide RS16830 Peptide tetrahydrodipicolinate OO69_RS24065 aminotransferase: 3-methylpentanoate erythritol 2,4- -D-muramate OO69_RS28505 SAM coenzyme A NADPH H an N-terminal L-homocysteine 2,5-dichloromaleylacetate (S)-5-hydroxyisourate ω salicyl-CoA gly hydroxybutanoate reductase yl)-3-hydroxybutanoate a quinoxaline-2- tetradecadienoate acyltransferase: OO69_RS06845 (meso-DAP containing) futalosine monoglutamate halocarboxylate halocarboxylate Gln 40 in tRNA proline ( = 180) 6-phosphate GTP phosphoribulosylformimino- OO69_RS20585 phosphate synthase: phospholipase C, carrier protein methionine [tRNA ] peptidylprolyl L-homoserine dihydrodipicolinate ketol-acid 2-isopropylmalate OO69_RS23605 O-phospho- FabG: fabG cyclodiphosphate ala carboxyl-[aryl- ser OO69_RS35625 D-gluconate Xaa-L-proline maleylacetate Asp-tRNA(Asn) RluA family bifunctional inositol-3- N-acetyl-L- OO69_RS35415 dihydroxy-acid a [CysO sulfur- glycine AICAR-phosphate reductase: synthase: leuA L-serine synthase: carrier protein] phosphocholine- D-glycerate 6-phosphate reductase: hydroxyisourate pseudouridine isomerase: salicylyl-CoA phosphate reductoisomerase: glutamate 5- dehydratase: ilvD 3-oxoacyl- (3Z)-dodec- endolytic /Glu-tRNA(Gln) diguanylate OO69_RS24605 indole-3-glycerol phosphate carrier protein]- OO69_RS15805 specific: dehypoxanthine holo-ACP dihydrofolate HAD family HAD family OO69_RS05230 hydrolase: uraH synthase: OO69_RS00385 synthase: oxidase Peptide RS13995 Peptide homoserine OO69_RS01790 [acyl-carrier- 3-enoyl-CoA UDP-N-acetyl- transglycosylase leucyl homocysteine S- amidotransferase: 5-hydroxylase/ cyclase: val semialdehyde synthase TrpC: trpC (3S)-3-methyl-2- thiocarboxylateCysO- 2-((1R,3S),-1',9'- OO69_RS12980 glycerate kinase: futalosine synthase: reductase: hydrolase: hydrolase: ThiO: thiO kinase: imidazole glycerol 4-hydroxy- (2S)-2- acetylornithine protein] quinoxaline-2- a 1,2-diacyl- α-D-muramoyl- aminopeptidase: methyltransferase: maleylacetate (S)-2-oxo-4- gatB gatA gatC OO69_RS32645 [+ 5 isozymes] oxidoreductase: OO69_RS39400 OO69_RS15655 ketol-acid oxopentanoate 2-C-methyl-D-erythritol- dihydroxy-1'-methyl- ∆3,∆2-enoyl- a phosphatidylcholine MltG: mltG OO69_RS05455 OO69_RS23385 OO69_RS23385 a [protein]-L- OO69_RS37450 phosphate tetrahydrodipicolinate isopropylmalate hydrogencarbonate thiocarboxylate- carboxyl-D-seryl-L- sn-glycerol γ OO69_RS06240 cyclase: mqnC OO69_RS09525 OO69_RS31070 mmuM reductase: hydroxy-4-carboxy- an L-glutaminyl- [+ 2 isozymes] OO69_RS14775 glyoxylate reductoisomerase: transaminase: reductase: 2,4-cyclodiphosphate CoA isomerase: L-alanyl- -D- [+ 3 isozymes] 38- Ins(3)P c-di-GMP synthase: hisH hisF (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate branched-chain dependent 10'-oxo-3',4',5',10'- [+ 2 isozymes] [+ 10 isozymes] [+ 10 isozymes] [tRNA Gln ] a pseudouridine proline (ω = 0) O-phospho- reductase: ilvC 3-isopropylmalate OO69_RS20600 fabG alanine synthase: glutamyl-meso-2,6- 2-phospho- OO69_RS27700 5-ureidoimidazoline gentisyl-CoA Peptide RS22520 glutamine- flavodoxin- tetrahydro-1H- OO69_RS35630 cyclic 40 in tRNA Peptide OO69_RS35295 dehydratase: amino acid cysteine synthase: OO69_RS34325 a 1-phosphatidyl- D-glycerate 2,5-dichloro- L-homoserine a (3R)-3- benzo[g]isochromen- diaminopimelate a nascent peptidoglycan 5'-deoxyadenosine a holo-[AsbD acyl- a peptide with (R)-2,3-dihydroxy- hydrolyzing N-acetyl-L- tryptophan synthase: aminotransferase: OO69_RS41020 dependent (2E)-dodec- 1D-myo-inositol a 1,2-diacyl- a mature peptidoglycan dehypoxanthine met 3',5'-ADP a proteinogenic 3-oxoadipate D-erythro-1-(imidazol-4- (S)-2,3,4,5- leuD leuC hydroxyhexanoyl- carrier protein] 5,6,7,8- + an (S)-2- a (2R)-2- threonine AICAR 3-methylpentanoate carbamoyl- ornithine trpB OO69_RS32830 (E)-4-hydroxy- 3'-yl)acetate 2-enoyl-CoA sn-glycerol with (L-alanyl-γ-D-glutamyl- (meso-DAP containing) futalosine NADP a halide anion a halide anion an N-terminal met yl)-glycerol 3-phosphate OO69_RS23605 adenylyltransferase/ [acp] a quinoxaline-2- 4,5-bisphosphate tetrahydrofolate hydroxycarboxylate hydroxy fatty acid amino acid synthase: tetrahydrodipicolinate meso-2,6-diaminopimeloyl- with GlcNAc terminus L-proline dihydroxy-acid 2-isopropylmaleate phosphate ser sulfurtransferase 3-methylbut- carboxyl-D-seryl-L- enoyl-CoA a purine RS06790 a purine imidazoleglycerol- 2,3,4,5- indole OO69_RS37445 dehydratase: synthase: ile MoeZ: moeZ a [CysO sulfur- 2-enyl- cys alanyl-[non-ribosomal val hydratase/ D-alanine) tetrapeptide phosphate 3-isopropylmalate a [CysO sulfur- threonine tetrahydropyridine- ilvD carA carB carrier protein]- diphosphate peptide synthase] isomerase dehydratase: carrier protein]- Aromatic Compound Degradation synthase: dehydratase 2,6-dicarboxylate N- Gly-NH-CH - synthase: ispG (S)-DNPA family protein: (2Z)-2- (3S)-3-methyl-2- tryptophan synthase: 2 a [2-oxoglutarate- 34 a thiocarboxylated an (S)-2- guanosine 2251 a [protein]- HisB: hisB succinyltransferase: leuD leuC carbamoyl L-ornithine Gly-Gly-adenylate a (2E)-hex- triacylglycerol a sulfurated coenzyme A an apo [peptidyl- coenzyme A an apo-[aryl- a uridine quercitrin O-succinyl-L- N-ethylmaleimide a uridine in tRNA a purine RS00935 a purine OO69_RS15605 oxopentanoate trpB OO69_RS32830 superpathway of L-cysteine C(O)-S-L-cysteine triostin A dithiol OO69_RS35630 SAM dehydrogenase [SAMP] C- a uracil in DNA L-homocysteine cys L-threonine 3- hydroxypenta- D-ala dapD phosphate 2-enoyl-[acp] flavodoxin- degradation 2,4,6-trichlorophenol degradation carrier protein] carrier protein] in tRNA halocarboxylate homoserine in 23S rRNA L-histidine 3-(imidazol-4-yl)-2- (2R,3S)-3- adenylyltransferase/ synthase: chlorpyrifos degradation phenylethylamine methyl parathion degradation [sulfur carrier] 6 alkene reductase: O-phosphate 2,4-dienoate branched-chain L-arginine biosynthesis II (acetyl cycle) biosynthesis (mammalian) dependent (S)-3- 4-sulfocatechol catechol degradation to 2- E2 protein] N - terminal glycine 23S rRNA tRNA histidine kinase: 2-keto-4- thr N-succinyl-2-amino- isopropylmalate enoyl-ACP OO69_RS14820 a triacyl-sn degradation I OO69_RS46255 homocysteine S- cysteine threonine- glycine oxopropyl phosphate amino acid sulfurtransferase (E)-4-hydroxy- hydroxydodecanoyl-CoA degradation hydroxypentadienoate II octanoyl-L-lysine (guanosine(2251) dihydrouridine OO69_RS42685 ornithine superpathway reductase -glycerol 2,4,6-trichlorophenol HAD family alpha-L-rhamnosidase: uracil-DNA methyltransferase: dioxygenase: phosphate pentenoate oxidase histidinol-phosphate 6-ketopimelate aminotransferase: 3-isopropylmalate trp MoeZ: moeZ 5-deoxy- triacylglycerol holo-ACP holo-ACP tRNA 2- cystathionine -2'-O)- alkene reductase: synthase a purine RS02795 a purine carbamoyltransferase: of L-threonine N-acetylglutamyl- met FabI: fabI 3-methylbut- enoyl-CoA chlorpyrifos methyl parathion OO69_RS14035 decarboxylase: [+ 6 isozymes] hydratase: ThiO: thiO threonine/serine dehydrogenase: dihydrokalafungin 4-sulfocatechol catechol 2-phenylethylamine lipoyl synthase: synthase: thiouridine(34) hydrolase: glycosylase: methyltransferase OO69_RS27905 mmuM OO69_RS41705 DusB: dusB a [protein]- transaminase: hisC succinyldiaminopimelate OO69_RS23605 argF biosynthesis amino-acid N- phosphate 2-enyl- triostin A dithiol hydratase/ lipase: phosphotriesterase: gamma-synthase: mhpD dehydratase: OO69_RS23610 protocatechuate catechol 2,3- primary-amine synthase: OO69_RS09525 OO69_RS09525 synthase OO69_RS23385 alpha-L-rhamnosidase: OO69_RS47735 RlmB: rlmB a 5,6-dihydrouridine (R)-1-amino-OO69_RS46420 N-phospho- (S)-4-hydroxy- pyruvate histidinol-phosphate transaminase: dapC acetyltransferase: methionine a hexanoyl-[acp] diphosphate isomerase OO69_RS00050 OO69_RS01805 OO69_RS36740 2-O- N-ethylsuccinimide met 3-sulfino-L-alanine OO69_RS13530 oxaloacetate 2,6-dichlorobenzoquinone 3,4-dioxygenase: dioxygenase: oxidase: phosphotriesterase: lipA MnmA: mnmA [+ 10 isozymes] OO69_RS44395 [+ 2 isozymes] in tRNA 2-propanol O L-histidine 2-oxopentanoate transaminase: ile (2S)-2-isopropyl- OO69_RS41380 adenosyltransferase: synthase: ispG family protein: triacylglycerol phosphotriesterase: 2251 D-ribose RS26130 D-ribose N-succinyl-L,L-2,6- aspartate pcaG pcaH OO69_RS24410 OO69_RS08190 OO69_RS01805 methylguanosine -2-phosphate threonine OO69_RS32745 3-oxosuccinate asp L-citrulline N-acetyl- OO69_RS21200 (E)-4-hydroxy-3- OO69_RS35630 OO69_RS05310 a holo [peptidyl- a holo-[aryl- diaminopimelate transaminase: bifunctional [CysO sulfur- 22-[(1R,3S)-5,9,10- lipase: 3-sulfomuconate HMS phenylacetaldehyde a [2-oxoglutarate 3',5'-ADP 3',5'-ADP in 23S rRNA ammonia-lyase: gamma-glutamyl- phosphotriesterase: an unsulfurated a [SAMP] C- a 2-thiouridine 34 an (S)-2- succinate an apyrimidinic uracil carrier protein] methylbut-2-en- trihydroxy-1-methyl- OO69_RS30660 diethylthiophosphate 5'-deoxyadenosine met dehydrogenase carrier protein] carrier protein] β-L-rhamnopyranose L-homocysteine OO69_RS36720 succinyl- OO69_RS29770 glutamate N- triostin A a 1,2-diacyl- OO69_RS05310 a halide anion quercetin L-histidinol phosphate phosphate SAM 1-yl diphosphate 3-oxododecanoyl-CoA 6 [sulfur carrier] terminal glycine in tRNA hydroxycarboxylate site in DNA diaminopimelate acetyltransferase/ 1H,3H,4H-naphtho[2,3- 3-sulfomuconate 2-hydroxymuconate E2 protein] N D-ribose RS12370 D-ribose (2Z)-2-aminobut- argininosuccinate asp reductase: sn-glycerol amino-acid a 3-oxooctanoyl- c]pyran-3-yl]acetate acetyl-CoA C- 2,6-dichlorohydroquinone cycloisomerase: 6-semialdehyde -lipoyl-L-lysine histidinol- desuccinylase: 4-methyl-2- synthase: argG acetylglutamate 2-enoate L-ornithine OO69_RS20585 [acp] pcaB dehydrogenase: dimethylthiophosphate 4-nitrophenol phosphatase: OO69_RS44970 oxopentanoate acetyltransferase acyltransferase: biosynthesis II aspartate kinase: kinase: argB 1-hydroxy-2- OO69_RS27850 phenylacetate ArgJ: argJ 3-oxoacyl- OO69_RS35625 an L-1- an apo-[LYS2 L- γ 34 3 1498 a plant (2Z)-2- OO69_RS31820 branched-chain L-arginino- OO69_RS34720 gln N-acetyl-L-glutamate methyl-2-butenyl 4-sulfomuconolactone (2Z,4E)-2- an L-lysyl- 3-[(1-carboxyvinyl) -butyrobetainyl- a [protein]-S- a uridine an N -methyladenine a [release factor]- an N-hydroxy- a uracil β a sugar RS41695 a sugar L,L-diaminopimelate glu N-acetyl-L-glutamate ammonia assimilation cycle III echinomycin diethylphosphate phosphatidyl- coenzyme A L-carnitine adenosylcobinamide aci-nitroethane roseoflavin MeOH hydroxyhexa- -D-allopyranose amino acid 5-semialdehyde ACP Lys 2-aminoadipyl- SAM in tRNA L-glutamine arylamine in 16S rRNA arabinogalactan L-homoserine L-asparagine histidinol- 2-oxoglutarate succinate SAH 4-diphosphate THN decanoyl-CoA a 2-acylglycerol hydroxyhexa- [tRNA ] oxy]benzoate CoA sulfanyl-L-cysteine in DNA reductase sn-glycerol carrier-protein] bifunctional peptide chain arylamine N- 16S rRNA type I bifunctional catalase/ 2,5-dienoate D-ribose biosynthesis I phosphatase: hisN glutamate aminotransferase: L-aspartyl- glutamine- acetylornithine reductase: 2-chloro-6-hydroxy- 2,4-dienedioate arabinogalactan 2-keto-4- 2-iminobutanoate diaminopimelate argininosuccinate cinnamate and 3-hydroxycinnamate adenosylcobinamide acetyltransferase: cystathionine riboflavin kinase/ peroxidase dehydrogenase: OO69_RS23605 4-phosphate hydrolyzing transaminase: ammonium FabG: fabG acyl-CoA/acyl-ACP 1,4-benzoquinone release factor (uracil(1498)-N(3))- pentenoate pyranase: epimerase: lyase: argH bifunctional 1-hydroxy-2- OO69_RS18385 degradation to 2-hydroxypentadienoate crotonobetainyl- tRNA 2- DNA-3- nitronate endo-1,4-beta- gamma-lyase: FAD synthetase: a sugar RS26605 a sugar histidinol OO69_RS18445 OO69_RS20600 adenosylhomocysteinase: dehydrogenase: bifunctional holo-ACP aminofutalosine kinase/ N(5)-glutamine OO69_RS21825 methyltransferase: HPI: katG rbsD carbamoyl- glutamate N- 3-oxoacyl- paraoxon degradation CoA--carnitine thiouridine(34) methyladenine monooxygenase: galactosidase: hydratase: asp OO69_RS41785 aspartate- OO69_RS44230 glu methyl-2-butenyl 4-hydroxy-3- 2-maleylacetate catechol degradation synthase: synthase adenosylcobinamide- methyltransferase: [+ 3 isozymes] OO69_RS40545 OO69_RS39515 OO69_RS35190 [+ 3 isozymes] glu leu phosphate [acyl-carrier- OO69_RS24980 lysylphosphatidylglycerol an N 3 - OO69_RS22475 mhpD β-D-allofuranose asparagine histidinol arg semialdehyde L-arginine acetyltransferase/ 2-oxoglutarateglutamate synthase glutamine 4-diphosphate methylbut-2-enyl glycerol cinnamate to β-ketoadipate OO69_RS09525 MqnE: mqnE CoA-transferase: synthase glycosylase I: phosphate OO69_RS40540 an N- roseoflavin synthase: protein] (3E)-2-oxohex- synthetase/lysine-- prmC 1498 2-oxobutanoate formaldehyde (S)-4-hydroxy- synthase meso-diaminopimelate degradation I amino-acid large subunit: gltB actinorhodin [+ 18 isozymes] OO69_RS12025 MnmA: mnmA OO69_RS44950 5 acetoxyarylamine methyluracil a galactotetraose dehydrogenase: hisD dehydrogenase: L-homocysteine ser synthetase: reductase: diphosphate 2-chlorobenzene- maleylacetate 3-enedioate paraoxon guanylyltransferase: [+ 4 isozymes] a [release factor]-N 5'-phosphate 2-oxohexanoate 2-oxobutanoate glutamate superpathway of L-serine carA carB acetyltransferase reductase: tRNA ligase LysX: lysX in 16S rRNA a sugar RS34965 a sugar (glutamine- histidinol OO69_RS34725 (arginase pathway) glutamate OO69_RS28960 OO69_RS18385 reductase: (2E)-dec-2-enoyl-CoA 1,4,6-triol reductase: catechol a holo-[LYS2 L- 6-amino-6- OO69_RS31010 -methyl-L-glutamine diaminopimelate 5-kinase: and glycine biosynthesis I fabG bifunctional 3- hydrolyzing) ArgJ: argJ dehydrogenase: OO69_RS05230 3',5'-ADP 34 acetolactate dehydrogenase: hisD aspartate- carbamoyl phosphate L-ornithine [+ 5 isozymes] 4-hydroxy-3- OO69_RS43920 6-chlorohydroxyquinol- catechol 1,2- 2-aminoadipyl- deoxyfutalosine met a [protein]- a 2-thiouridine an apurinic site adenosyl-cobinamide decarboxylase: OO69_RS40340 arg a (3R)-3- ∆ 2 phenylpropionate/ phosphotriesterase: γ-butyrobetaine (R)-carnitinyl-CoA 3-methyladenine : asnB cystathionine OO69_RS18445 trans- -decenoyl- maleylacetate dioxygenase: 3-O-L-lysyl-1-O- carrier-protein] acetaldehyde nitrite synthase: 3-phospho-D-glycerate semialdehyde methylbut-2-enyl 1,2-dioxygenase: cinnamic acid protocatechuate degradation Lys L-cysteine in tRNA within DNA phosphate histidinal OO69_RS32140 γ-L-glutamyl L-tyrosine N-acetyl-L-ornithine hydroxyoctanoyl- CoA hydratase: (2Z)-2- OO69_RS01805 a tRNA OO69_RS27825 [+ 2 isozymes] phosphoglycerate L-phenylalanine beta-synthase: Asp-tRNA(Asn) diphosphate OO69_RS27695 3-hydroxycinnamate reductase: OO69_RS11955 phosphatidylglycerol a sugar RS12260 a sugar [+ 2 isozymes] biosynthesis I dehydrogenase: [acp] dioxygenase II (ortho-cleavage pathway) hydroxypenta- phosphotriesterase: asn 5-phosphate biosynthesis I OO69_RS32065 /Glu-tRNA(Gln) OO69_RS35630 OO69_RS27700 cis,cis-muconate [+ 2 isozymes] histidinol dehydrogenase: OO69_RS33340 reductase: ferredoxin subunit: OO69_RS05310 glutamate-5- L-ornithine ammonium gln IPP (S)-3- 2-chloromaleylacetate 2,4-dienoate (S)-2-aceto-2- dehydrogenase: hisD lys chorismate OO69_RS03335 amidotransferase: OO69_RS43920 OO69_RS26495 protocatechuate chorismate L-aspartate 4- hydroxydecanoyl-CoA 3-oxoadipate a 7-aminomethyl-7- an [RNA]-3'- (9Z,15Z)-12,13- semialdehyde chorismate gatB gatA gatC protocatechuate lysine within crotonobetainyl- (S)-5-amino-3- a long-chain + 3-amino-4- an organic dCTP hydroxybutanoate histidinol phosphoglycerate maleylacetate 34 coenzyme A [EntB aryl- L-carnitine acetyl-CoA NADPH H 3-sulfocatechol ethanol a sugar RS16640 a sugar chorismate semialdehyde ornithine- ornithine L-cystathionine deazaguanosine SAM an octanoyl-[acp] a type IV prepilin ribonucleoside- epoxy-octadeca- Ins(2)P D-glycerate dehydrogenase: hisD dehydrogenase: mutase: dehydrogenase: [+ 11 isozymes] a (2E)-oct- (S)-3- (2E)-3-(5,6- 3,4-dioxygenase: diethylphosphate 4-nitrophenol gcv protein H carrier protein] CoA oxohexanoate fatty acyl-CoA hydroxybenzoate hydroperoxide ketol-acid uracil degradation isopentenyl- reductase: in tRNA arylamine N- 9,15-dienoate alkyl catalase/ deoxycytidine OO69_RS40350 OO69_RS44825 OO69_RS23670 mutase: homoserine -oxo-acid carbamoyltransferase: 2-enoyl-[acp] hydroxydecanoyl- dihydroxycyclohexa-1,3- pcaG pcaH 2',3'- inositol D-glycerate reductoisomerase: I (reductive) diphosphate OO69_RS05230 (+)-muconolactone acetyltransferase: epoxide peroxidase triphosphate OO69_RS44825 dehydrogenase: transaminase: argF cystathionine gamma- CoA dien-1-yl)prop-2-enoate 3-carboxy-cis,cis-muconate cyclophosphateRNA 2',3'-cyclic monophosphatase: dehydrogenase: hydroperoxide OO69_RS01790 L-glutamate his L-glutamate-5- [+ 2 isozymes] 3-phosphooxypyruvate enoyl-ACP Delta- maleylacetate lipoyl(octanoyl) crotonobetainyl- 3-keto-5- long-chain- catechol 2,3- hydrolase: deaminase: OO69_RS37440 rocD uracil lyase: OO69_RS39515 dehydrogenase: S-adenosylmethionine:tRNA holo-ACP OO69_RS44260 OO69_RS14055 OO69_RS29805 reductase: HPI: katG a sugar RS12365 a sugar biosynthesis III semialdehyde prephenate [+ 2 isozymes] glu reductase isomerase: idi catechol degradation to CoA--carnitine aminohexanoate fatty-acyl-CoA prepilin peptidase: dioxygenase: phosphodiesterase: OO69_RS13350 OO69_RS36165 ketol-acid alanine prephenate reductase: 3-carboxy- parathion degradation transferase synthase: [+ 3 isozymes] OO69_RS43785 [+ 3 isozymes] phosphoserine ornithine- OO69_RS35630 ribosyltransferase- OO69_RS24410 thpR (9Z,15Z)-12,13- [+ 2 isozymes] reductoisomerase: racemization ornithine- L-homoserine FabI: fabI OO69_RS27700 2-hydroxypentadienoate I cis,cis-muconate LipB: lipB OO69_RS09525 CoA-transferase: cleavage protein: reductase: OO69_RS43740 an [RNA]-3'- 3-acetylamino-4- hydroxypyruvate [+ 2 isozymes] 2-oxoglutarate prephenate transaminase: serC -oxo-acid cys isomerase: OO69_RS50915 dihydroxyoctadeca- myo-inositol an alcohol acetaldehyde ilvC -oxo-acid prephenate cycloisomerase: pcaB (4,5-dihydro-5- OO69_RS12025 OO69_RS28370 OO69_RS01620 ribunucleoside- hydroxybenzoate dUTP glutamate dehydrogenase: transaminase: 5,6-dihydrouracil methylerythritol phosphate pathway II 3-oxodecanoyl-CoA 5-chloro-3-oxoadipate parathion 9,15-dienoate dehydratase: homoserine an octanoyl-[acp] DMAPP catechol a [glycine-cleavage (2Z,4E)-2- 2'-phosphate a sugar RS19965 a sugar (R)-2,3-dihydroxy- synthase large ala transaminase: OO69_RS42095 rocD L-glutamate 2,3-dihydroxy-trans-cinnamate (2-carboxy-2,5-dihydro- oxofuran-2-yl)-acetate O-phospho-L-serine acetyl-CoA C- an epoxyqueuosine 34 complex H protein] 3',5'-ADP a holo-[EntB aryl- hydroxyhexa- sulfite 3-methylpentanoate alanine racemase: rocD 3-(4- pheA kinase: L-citrulline dihydropyrimidinase: 5-oxofuran-2-yl)-acetate 3-oxoadipate acyl-carrier protein (S)-3- a long-chain a cleaved type subunit: gltB biosynthesis II D-glyceraldehyde catechol 2,3- met 6 carrier protein] crotono-betaine (R)-carnitinyl-CoA acetoacetate a peptide L-alanine OO69_RS39420 hydroxyphenyl) 3-phenyl-2- OO69_RS37450 L-glutamate-5- pyruvate acyltransferase: phosphotriesterase: adenine in tRNA N -octanoyl-L-lysine IV prepilin 2,4-dienedioate dihydroxy-acid glutamate ornithine- hydA 3-phosphate dioxygenase: carboxymuconolactone enol-lactonase: aminobutanoyl-CoA fatty aldehyde biosynthesis III pyruvate phosphoserine oxopropanoate semialdehyde OO69_RS35625 OO69_RS01805 a sugar RS08035 a sugar dehydratase: dehydrogenase: alanine -oxo-acid O-phospho- argininosuccinate dihydropyrimidinase: 2-oxoglutarate OO69_RS24410 decarboxylase: pcaD aspartate phosphatase SerB: serB (2Z,4E,7E)-2-hydroxy- phosphotriesterase: ilvD OO69_RS18445 racemase: alr transaminase: aspartate L-homoserine L-glutamate synthase: argG hydA glycine glutamate 1-deoxy-D- octanoyl-CoA 2-maleylacetate OO69_RS24425 transaminase: a 3-oxodecanoyl- 6-oxonona-2,4,7- 3-oxoadipate OO69_RS05310 cys D-ala rocD transaminase: gamma- biosynthesis IV dehydrogenase: HMS (3S)-3-methyl-2- threonine [acp] xylulose-5- 4-carboxymuconolactone 2503 527 (9Z,12Z)-15,16- glu cysteine OO69_RS29770 ser 3-ureidopropanoate maleylacetate triene-1,9-dioate adenine an [HPr]- phosphoenol D-cellobiose + a guanine L-malic (indol-3-yl) CTP OO69_RS29770 semialdehyde L-arginino-succinate OO69_RS18445 phosphate acyl-CoA/acyl-ACP coenzyme A [EntF L-seryl- uroporphyrinogen-III coenzyme A NADP FMNH succinate formyl-CoA DNA with lesion D-glycerate a sugar RS25525 a sugar oxopentanoate synthase: decarboxylase: pcaC in 23S rRNA L-histidine pyruvate 6'-phosphate VibB 2 epoxyoctadeca- Ins(1)P desulfurase: L-ornithine dehydrogenase: 3-oxoacyl- dehydrogenase: reductase: 4-nitrophenol carrier protein] in 16S rRNA semialdehyde acetonitrile deoxycytidine branched-chain tyr OO69_RS37445 β thr glu synthase: (4,5-dihydro-5- diethylthiophosphate uroporphyrinogen-III C- 16S rRNA excinuclease 9,12-dienoate aldehyde nitrile hydratase: OO69_RS23835 serine phe pruA argininosuccinate -ureidopropionase: ACP OO69_RS24980 OO69_RS05230 inositol D-glycerate threonine OO69_RS35685 oxofuran-2-yl)-acetate methyltransferase: cobA (guanine(527)-N(7) ABC subunit UvrA: epoxide dehydrogenase OO69_RS40925 triphosphate amino acid hydroxymethyltransferase: threonine lyase: argH OO69_RS06450 reductase formyl-CoA monophosphatase: dehydrogenase: [+ 3 isozymes] [+ 18 isozymes] maleylacetate 23S rRNA phosphoenolpyruvate- 6-phospho-beta- holo-ACP flavin reductase: OO69_RS04290 hydrolase: deaminase: aminotransferase: OO69_RS23940 synthase: aldolase: 1-deoxy-D- (2Z)-2- holo-ACP bifunctional )-methyltransferase OO69_RS29805 (NADP(+)): OO69_RS40930 a sugar RS23200 ala glu FabG: fabG reductase: (2Z)-2-hydroxypenta- formate 3-oxoadipate enol- (adenine(2503)-C(2) -protein glucosidase: OO69_RS05575 transferase: OO69_RS13350 OO69_RS14055 OO69_RS36165 a sugar OO69_RS41425 fumarate hydroxypenta- synthase: uroporphyrinogen-III synthase: 7 RsmG: rsmG [+ 3 isozymes] OO69_RS26040 nthA OO69_RS23605 [+ 3 isozymes] OO69_RS15605 β-alanine xylulose-5- (2E)-oct-2-enoyl-CoA 2,4-dienoate lactonase: pcaD phosphotransferase: ptsP frc an N - (9Z,12Z)-15,16- [+ 2 isozymes] arg 3-oxoacyl- OO69_RS27700 2,4-dienoate )-methyltransferase OO69_RS09525 OO69_RS17640 OO69_RS09525 [+ 7 isozymes] DNA without hydroxypyruvate (indol-3-yl) [+ 2 isozymes] [+ 2 isozymes] phosphate C-methyltransferase/ methylguanine 527 dihydroxyoctadeca- (S)-malate [acyl-carrier- RlmN: rlmN [+ 2 isozymes] lesion myo-inositol acetamide ile gly thr gly synthase: enoyl-CoA 3-oxoadipate diethylphosphate uroporphyrinogen-III 9,12-dienoate UTP protein] 3-oxoadipate an [HPr protein]- in 16S rRNA a sugar RS27780 a sugar OO69_RS18400 hydratase/ a holo-[EntF synthase: OO69_RS21795 reductase: N π -phospho- pyruvate 3',5'-ADP 3',5'-ADP a holo-[VibB aryl- FMN NADPH H + formate succinyl-CoA isomerase a 2-methyladenine 2503 L-seryl-carrier D-glucopyranose fabG 5'-deoxyadenosine L-histidine precorrin-2 D-glucopyranose carrier protein] 1-deoxy-D-xylulose family protein: in 23S rRNA met protein] 6-phosphate a (3R)-3- 5-phosphate OO69_RS35630 a sugar RS28020 a sugar hydroxydecanoyl- 1-deoxy-D-xylulose- (S)-3- Metabolic Regulator Biosynthesis Carbohydrate Biosynthesis [acp] 5-phosphate hydroxyoctanoyl-CoA a single all-trans- RNase III mRNA a single- β-D-fructofuranose a guanine 966 (12Z,15Z)-9,10- (2S)- (3E)-5-chloro-2- ARP methanethiol O-succinyl-L- FMN NADH H + 3-oxopropanoate epoxyoctadeca- D-glucopyranose benzaldehyde acryloyl-CoA reductoisomerase: enoyl-CoA tyr SAM stranded DNA octaprenyl processing stranded RNA 1-phosphate in 16S rRNA ethylmalonyl-CoA oxopent-3-enoate 2+ 2+ α D-galactose degradation I (Leloir pathway) Carbohydrate Degradation homoserine 4-hydroxybenzoate Zn RS33570 Zn mannosylglucosylglycerate glycogen biosynthesis III (from -maltose 1-phosphate) OO69_RS35025 diphosphate substrate 16S rRNA malonic 12,15-dienoate glucose 1- aldehyde crotonyl-CoA 2-keto-4- ppGpp metabolism trehalose glucosylglycerate trehalose biosynthesis I UDP-N-acetyl-D- glycogen biosynthesis I (from ADP-D-Glucose) β PRPP biosynthesis hydratase/ L-rhamnose degradation I 2-deoxy-D-ribose degradation II glycogen degradation II epoxide methylmalonyl- biosynthesis I dTDP- -L-rhamnose (guanine(966)-N(2) semialdehyde dehydrogenase: dehydrogenase carboxylase/ pentenoate biosynthesis V biosynthesis I glucosamine biosynthesis I a (2E)-dec- isomerase exodeoxyribonuclease polyribonucleotide flavin reductase: class II fructose- hydrolase: CoA D-glucopyranose biosynthesis MEP β-D-galactopyranose α-L- 2-deoxy-β-D- cystathionine )-methyltransferase reductase: OO69_RS43365 (NADP(+)): reductase: hydratase: 3-phospho- D-glucopyranose ADP-α-D-glucose D-glucopyranose D-ribose 5- 2-enoyl-[acp] family protein: bifunctional FO VII: OO69_RS43905 4-hydroxybenzoate nucleotidyltransferase: bisphosphate epimerase: mce UDP-α-D-glucose pppGpp 3-phospho- α 6-phosphate D-glucopyranose α a glycogen gamma-synthase: ribonuclease III: OO69_RS05575 OO69_RS13350 Zn 2+ RS37100 Zn 2+ D-glycerate a glycogen UDP- -D-glucose -D-glucopyranose OO69_RS35630 rhamnopyranose ribopyranose biosynthesis protein octaprenyltransferase: 2 RsmD: rsmD OO69_RS43900 (12Z,15Z)-9,10- [+ 7 isozymes] OO69_RS26040 ccrA mhpD GDP-α-D-glucose 6-phosphate 6-phosphate phosphate enoyl-ACP aldose epimerase: OO69_RS43910 OO69_RS23235 OO69_RS35285 aldolase: fbaA an N - (2R)- glycogen D-glycerate 6-phosphate 1-phosphate ribose-phosphate 2-C-methyl-D- OO69_RS36740 [+ 7 isozymes] D-glucono- (R)-methylmalonyl- 5-chloro-4-hydroxy- glucose-6- L-rhamnose CofGH: OO69_RS43315 OO69_RS22195 methylguanine 966 3-hydroxypropanoate dihydroxyoctadeca- ethylmalonyl-CoA benzoate bifunctional (p)ppGpp alpha-D-glucose glucose-1-phosphate pyrophosphokinase: reductase erythritol 4-phosphate OO69_RS34395 1,5-lactone CoA 2-oxopentanoate glucosyl-3- debranching 3-oxooctanoyl-CoA mutarotase: 12,15-dienoate synthetase/guanosine- trehalose-6- phosphate FabI: fabI [+ 2 isozymes] in 16S rRNA guanosine 3'- protein glucosyl-3- phosphate-specific thymidylyltransferase: OO69_RS03640 cytidylyltransferase: chitin degradation II (Vibrio) a single-stranded RNase III a single- phosphoglycerate phosphate isomerase: pgi OO69_RS03815 2-deoxy-ribono- a ribonucleoside succinate a nucleoside + DHAP D-glyceraldehyde sulfite RS45180 sulfite 3',5'-bis(diphosphate) 3'- diphosphate 5'- phosphoglucomutase: OO69_RS33075 OO69_RS15810 acetyl-CoA C- 5-amino-5-(4-hydroxybenzyl)-6- met 4-hydroxy-3- an mRNA fragment FMNH NAD GlgX: glgX phosphoglycerate ribose-phosphate a decanoyl-[acyl- α-D-galactopyranose an α-limit dextrin 5'-deoxyadenosine 2-iminoacetate 5'-monophosphate oligodeoxyribonucleotide processing diphosphate stranded RNA 2 synthase: pyrophosphohydrolase: synthase: trehalose-6- glucose-6- acyltransferase: [+ 2 isozymes] 1,5-lactone (D-ribitylimino)-5,6-dihydrouracil met octaprenylbenzoate triphosphate 3'- synthase: OO69_RS12065 glucose-1-phosphate diphosphokinase: carrier protein] 4-(cytidine 5'- chitin product mRNA OO69_RS15610 OO69_RS41790 [+ 5 isozymes] OO69_RS15615 phosphate phosphate OO69_RS35625 β-L- diphosphatase: OO69_RS15610 [+ 2 isozymes] thymidylyltransferase: OO69_RS31765 diphospho)-2-C- galactokinase: 4-alpha- a maltodextrin synthase: isomerase: pgi rhamnopyranose α-D- methyl-D-erythritol glucanotransferase: chitinase: 2+ 2+ 2-O-(α-D- OO69_RS41790 OO69_RS03205 PRPP hexanoyl-CoA galK Cd CadA Cd α α,α-trehalose OO69_RS15615 F6P dTDP-α-D-glucose L-rhamnose OO69_RS22955 glucopyranosyl) malto- 2-O-( -D- glucopyranose 4-(cytidine 5'- 2-deoxy- malQ a [mycoredoxin]- mycothiol- a 2,3,4-saturated S-methyl-5- a double-stranded 6-phosphate α a peptidoglycan fumarate + D-glucopyranose α oligosyltrehalose glucopyranosyl) 1-phosphate a 3- diphospho)- -D-galactose isomerase: a debranched [+ 6 isozymes] meso-diaminopimelate α 1,2-diacyl-sn- a tRNA precursor asp FMN NAD(P)H H canavaninosuccinate thio-D-ribulose 4-methylcatechol a primary amine an aldehyde wound RNA CAIR -3-phospho- GDP- -D- glutamine-- dTDP-glucose 4,6- acyl-CoA/acyl-ACP UDP-α-D-glucose D-ribonate UDP-N-acetyl- -D-muramoyl- L-cysteine arsenate conjugate oligonucleotide GTP ppGpp synthase: treY -3-phospho- trehalose- glucose-1-phosphate oxododecanoyl- 2-C-methyl-D- 1-phosphate rhaI α-limit dextrin glycerol 3-phosphate CTP 1-phosphate glucose 1- aldehyde ATP- 5-(carboxyamino) D-glycerate mannose fructose-6- dehydratase: rfbB α dehydrogenase: a chitodextrin L-alanyl-D-glutamate catechol 2,3- primary-amine D-glycerate trehalose biosynthesis II phosphatase: alpha-D-glucose UDP- -D-galactose erythritol kinase: methylthioribulose oligoribonuclease: dehydrogenase: dehydrogenase imidazole thiol CydD thiol a maltooligosyl- adenylyltransferase: [acp] OO69_RS24980 keto-L-rhamnulose muramidase: dioxygenase: oxidase: dependent phosphate-specific phosphate dTDP-glucose 4,6- biosynthesis FMN reductase: 1-phosphate orn trehalose otsB α,α-trehalose glgC 3-oxoacyl- OO69_RS38670 mycoredoxin: phosphatidate L-aspartate argininosuccinate OO69_RS02705 (NADP(+)): RNA helicase ribonucleotide D-glucopyranose phosphoglucomutase: transaminase dehydratase: rfbB [+ 18 isozymes] 2-deoxy- UDP-N-acetylmuramoyl- OO69_RS24050 ribonuclease Z: OO69_RS22000 dehydratase: mtnB OO69_RS24410 OO69_RS08190 nucleoside- ADP-α-D-glucose 6-phosphate a (1->4)- ACP 2-phospho-4-(cytidine OO69_RS19690 cytidylyltransferase: oxidase: lyase: argH (2Z,4E)-2-hydroxy- [+ 7 isozymes] OO69_RS26040 HrpA: hrpA mutase: purE malto- 6-phosphate α,α-trehalose OO69_RS12065 (isomerizing) ADP-α-D-glucose dTDP-4-dehydro-6- UDP-α-D-glucose pro L-alanyl-D-glutamate-- [+ 2 isozymes] OO69_RS40570 5-(methylsulfanyl) a nucleoside 5'- α diphosphate GDP α α-D-glucan reductase 5'-diphospho)-2-C- (2E)-hexenoyl-CoA 3-dehydro- α-D- OO69_RS41410 [+ 7 isozymes] 5-methyl-6-oxohexa- D-glucono- an aldehyde a reduced 2-[2-O-( -D- oligosyltrehalose 2-O-( -D- trehalose- : glmS deoxy-α-D-glucopyranose D-glucopyranose 2, 6-diaminopimelate OO69_RS23025 -2,3-dioxopentyl monophosphate a carboxylate an unwound RNA AIR kinase: ndk pyrophosphokinase: bifunctional (p)ppGpp [+ 2 isozymes] UDP-glucose methyl-D-erythritol D-ribonate glucopyranose a chitodextrin 1,5-lactone H O c-type mannopyranosyl) glucopyranosyl) phosphatase: glycogen FabG: fabG 2,4-dienoate 2 cbb3-type synthetase/guanosine- trehalohydrolase: trehalose-6- dTDP-4- 4-epimerase enoyl-CoA ligase: OO69_RS32560 a [mycoredoxin] N-acetyl-D- a N-acetylmuramoyl- 1-phosphate α OO69_RS41790 glutamine-- synthase: 2-C-methyl-D- L-rhamnulofuranose 1-phosphate cytochrome cytochrome -(1->2)- -D- -D-glycerate otsB 3-oxoacyl- arsenite mycothiolyl-S-S- a single-stranded + L-canavanine fumarate an oxidized 3',5'-bis(diphosphate) 3'- treZ phosphate dehydrorhamnose GalE: galE erythritol 2,4- hydratase/ ROK family glucosamine pentapeptide- a CDP-2,3,4-saturated- 2-iminosuccinate succinate FMNH NAD(P) glucopyranosyl]- fructose-6- glgA [acyl-carrier- mature tRNA 2 O c oxidase c-type pyrophosphohydrolase: synthase: α α 3,5-epimerase: rfbC isomerase rhamnulokinase: UDP-N-acetyl-α-D-muramoyl-L-alanyl- L-cysteine disulfide diphosphoundecaprenol oligoribonucleotide 2 α,α-trehalose , -trehalose phosphate a (1->4)- [+ 3 isozymes] an L-prolyl- cyclodiphosphate alpha-D-glucose glucokinase: diacylglycerol a reduced 3-phospho- OO69_RS41790 OO69_RS15615 UDP-α-D-galactose protein] family protein: OO69_RS03850 γ-D-glutamyl-meso-2,6-diaminopimelate cytochrome trehalose biosynthesis IV transaminase α-D-glucan dTDP-4- [RedO prolyl- synthase: phosphate-specific OO69_RS32360 H O c-type D-glycerate maltose alpha-D- reductase: D-glyceroyl-CoA acetoacetate 2 cbb3-type GDP dehydrorhamnose OO69_RS15805 OO69_RS35630 L-rhamnulose α α (isomerizing) 1,4-alpha- fabG carrier protein] phosphoglucomutase: ROK family beta-N- cytochrome cytochrome , -trehalose glucosyltransferase: 1-phosphate an oxidized α : glmS 3,5-epimerase: rfbC 2-C-methyl-D-erythritol- (S)-3- acetoacetate- OO69_RS12065 glucokinase: acetylhexosaminidase: UDP-N-acetyl- decaprenyl-diphospho-N- 5-amino-4- an N-arachidonoyl-1-acyl-2- 3,4-dihydroxyphenylacetyl- 2-hydroxy-2- 6-phosphate -maltose treS glucan GDP-mannose biosynthesis a (3R)-3- a β-D-galactoside a 1-haloalkane 2-oxoglutarate ectoine 3'-ketolactose a 28S rRNA O c oxidase c-type dTDP-4-dehydro- α-D-glucosamine acetylmuramoyl-pentapeptide PRPP a [protein] Ser/Thr an acyl phosphate vernolate homogentisate crotonyl-CoA an aliphatic nitrile 2 maltose alpha-D- D-glucosamine branching hydroxydodecanoyl- 2,4-cyclodiphosphate hydroxyhexanoyl-CoA -CoA ligase: [+ 2 isozymes] OO69_RS06565 OO69_RS17950 imidazolecarboxyamide lysophosphatidylethanolamine CoA methylpropanenitrile a reduced 2-[2-O-(α-D- trehalose- maltose alpha-D- β-L-rhamnose bifunctional serine/threonine RICIN domain- nitrile crotonyl-CoA nitrile cytochrome glucosyltransferase: treS 6-phosphate enzyme: D-glucopyranose [acp] 3-hydroxyhexanoyl- UDP-glucose:α- OO69_RS21685 beta-N- epoxide homogentisate H O c-type a 1H-pyrrole- flavodoxin- UDP-glucose 2 mannopyranosyl) phosphatase: glucosyltransferase: 6-phosphate dTDP-4- rhamnulose- undecaprenyldiphospho- protein kinase: acylphosphatase: containing protein: hydratase carboxylase/ hydratase maltose alpha-D- phosphoglucosamine glgB 2-carbonyl- CoA D-galactose- D-glycerate acetylhexosaminidase: adenine beta-glucosidase: hydroxyphenylacetyl- haloalkane ectoine beta-glucosidase: hydrolase: 1,2-dioxygenase: cytochrome -(1->2)-α-D- otsB α treS glucose-6- dependent 4-epimerase 1-phosphate acetoacetyl-CoA lysophospholipase: OO69_RS42375 OO69_RS23215 OO69_RS03110 subunit reductase: subunit RS48220 an oxidized glucosyltransferase: treS -D- dehydrorhamnose dehydrogenase: 1-phosphate OO69_RS40800 muramoylpentapeptide beta-N- OO69_RS40695 OO69_RS40695 OO69_RS13350 hmgA glucopyranosyl]- mutase: OO69_RS09465 1,4-alpha- phosphate [RedO prolyl- (E)-4-hydroxy- GalE: galE N,N'- N,N',N''- phosphoribosyltransferase: CoA thioesterase dehalogenase: hydroxylase: O c-type reductase: rfbD aldolase/ acetylglucosaminyltransferase: OO69_RS02300 [+ 33 isozymes] (9Z)-12,13- [+ 10 isozymes] alpha: nthA ccrA alpha: nthA 2 α,α-trehalose α,α-trehalose glucopyranose α α-maltose OO69_RS18220 uridylyltransferase: glycerate kinase: triacetylchitotriose [+ 4 isozymes] PaaI: paaI OO69_RS38555 thpD [+ 4 isozymes] 4-maleyl- D-glycerate ADP- -D-glucose α-D-glucosamine glucan isomerase: pgi carrier protein] 3-methylbut- acetyl-CoA C- diacetylchitobiose OO69_RS20995 a [protein] (L-serine/L- a carboxylate dihydroxyoctadeca- a 28S rRNA (2S)- a primary cytochromea reduced 1-phosphate a (2E)-dodec- galT [+ 3 isozymes] short-chain OO69_RS06240 murG acetoacetate 2-hydroxyisobutyramide branching dTDP-β-L-rhamnose 2-enyl- 3-hydroxyacyl-CoA α-D-glucopyranose acyltransferase: beta-N- fragments ethylmalonyl-CoA aliphatic amide H O c-type 1-phosphate glucose-6- UDP-α-D-galactose dehydrogenase: threonine) phosphate 9-enoate 2 2-enoyl-[acp] dehydrogenase: sn-glycero-3-phospho- β maltokinase: enzyme: phosphate malonyl-CoA diphosphate tunicamycin biosynthesis 1-phosphate 2-phospho- OO69_RS35625 acetylhexosaminidase: a non galactosylated (3,4- 3-keto- -D- RS03100 cytochrome bifunctional UDP-N- OO69_RS03845 D-galactopyranose N-(arachidonoyl) a fatty acid D-glucopyranose an oxidized enoyl-ACP synthase: ispG OO69_RS35630 D-glycerate [+ 7 isozymes] OO69_RS40800 decaprenyl-pyrophosphoryl- UDP AICAR coenzyme A dihydroxyphenyl) a halide anion a primary alcohol 5-hydroxyectoine succinate galactose OO69_RS13855 acetylglucosamine glgB isomerase: pgi a [RedX acyl- D-glucopyranose galactose acceptor O c-type UTP alpha-D-glucose (N-acetylglucosamine)-N- ethanolamine 2 F6P reductase carrier protein]- UDP-N-acetyl- beta-N- acetate cytochromea reduced diphosphorylase/ a glycogen α flavodoxin- 3-oxohexanoyl-CoA phosphate-specific acetyl-CoA 6-phosphate acetylmuramyl-(pentapeptide) α-maltose 1- UDP- -D-glucose FabI: fabI α DHAP (S)-lactaldehyde H O c-type glucosamine-1- (1H-pyrrole- dependent -D-glucosamine nucleoside triphosphate acetylhexosaminidase: 2 phosphate mannose-6- biosynthesis phosphoglucomutase: L-arabinose phosphate N- 2-carbonyl) (E)-4-hydroxy- pyrophosphohydrolase: acetyl-CoA C- OO69_RS17950 RS10830 ancytochrome oxidized phosphate a dodecanoyl-[acp] a malonyl-[RedN] OO69_RS12065 degradation I (1,4)-β-D-xylan a [glycine-cleavage a 1-(1-alkenyl) a methyl-esterified an [amino-group carrier alpha-1,4-glucan-- acetyltransferase D-glucopyranose malonyl-CoA -L-cysteine 3-methylbut- OO69_RS31955 acetyltransferase: N-acetyl-D- UDP-N-acetyl-α-D-muramoyl- a 1-O-(alk-1-enyl)-sn-glycero- an N-arachidonoyl-2-acyl-1- an organic (3Z)-hex- O c-type isomerase: [+ 2 isozymes] D-alanyl-D-alanine 3-phenylpropanoate γ trans-aconitate formaldehyde ferroheme o 2 maltose-1-phosphate 6-phosphate OO69_RS01580 degradation glucosamine a sulfurated [sulfur carrier] SAM complex H protein] γ 3-phosphoethanolamine lysophosphatidylethanolamine -sn-glycero-3- homogalacturonan protein]-C-terminal- - molecule 3-en-1-ol thr asp L-dopa GlmU: glmU 2-enyl- UDP-6-deoxy-5,6-ene- UMP L-arabinopyranose 6 L-alanyl- -D-glutamyl-L-lysine cytochrome OO69_RS44205 alpha-D-glucose sucrose degradation III (sucrose invertase) N -octanoyl-L-lysine phosphocholine bifunctional 3- (L-ornithyl)-L-glutamate CHAT domain- formaldehyde maltosyltransferase: N-acetyl-α-D- diphosphate N-acetyl-D-glucosamine [+ 7 isozymes] D-glucopyranose L-arabinose acetylornithine trans-aconitate 2- phosphate-specific ribose a (1->4)-β-D-xylan phenylpropionate/ chloroperoxidase: containing protein: dehydrogenase, heme A synthase: L-threonine 3- aspartate aromatic amino OO69_RS04800 mannose-6- synthase: ispG bifunctional 6-phosphate isomerase: pectinesterase: methyltransferase: glucosamine phosphoglucomutase: endo-1,4-beta- sucrose chitobiose degradation UDP-N-acetylmuramoyl- transaminase: OO69_RS48480 OO69_RS25645 dehydrogenase: transaminase: acid lyase: a (1->4)- phosphate a malonyl-[RedL a dodecanoyl- a 3-oxo-3-(1H metallophosphatase/ butanoyl-CoA phosphorylation lysoplasmalogenase: lysophospholipase: cinnamic acid OO69_RS31725 OO69_RS04940 glutathione- Cell Structure Biosynthesis peptidoglycan maturation (meso-diaminopimelate containing) 1-phosphate (E)-4-hydroxy-3- araA xylanase: lipoyl tripeptide--D-alanyl-D- lysoplasmalogenase: OO69_RS17315 OO69_RS20600 tdh OO69_RS29770 OO69_RS32105 α isomerase, OO69_RS12065 [RedQ acyl- -pyrrol-2-yl) OO69_RS42830 OO69_RS02300 dioxygenase (E)-3- [+ 3 isozymes] independent: fdhA -D-glucan polyketide methylbut-2-en- 5'-nucleotidase: rhamnogalacturonan type L-ribulose synthase: lipA [+ 2 isozymes] an [amino-group carrier an organochlorine bifunctional UDP-N- [+ 2 isozymes] UDP-N- acyl-CoA/acyl-ACP β-D-ribopyranose OO69_RS48140 N,N'-diacetylchitobiose alanine ligase: murF OO69_RS42830 ferredoxin subunit: (methoxycarbonyl) (3Z)-hex-3- ferroheme a aminoacetone oxaloacetate dopamine lipid II (meso class I: manA α-D-glucopyranose synthase] carrier protein] propanoyl-[RedN] 1-yl diphosphate OO69_RS36155 I degradation II (bacteria) sucrase protein]-C-terminal-γ-(L- compound formate 1,4-alpha- acetylglucosamine acetylgalactosamine- dehydrogenase: D-ribose endo-1,4-beta- 6'-phosphate pent-2-enedioate en-1-yl acetate D-mannopyranose 1-phosphate ribulokinase: ferredoxin: sn-glycero-3-phospho- OO69_RS26495 glutamate 5-semialdehyde- diaminopimelate containing) glucan diphosphorylase/ uridine OO69_RS24980 UDP-N-acetyl-α-D-muramoyl-L-alanyl- sn-glycero-3- 3-(5,6-dihydroxycyclohexa- 5,6-ene a rhamnogalacturonan type I araB pyranase: xylanase: OO69_RS30115 a [glycine-cleavage a fatty aldehyde a fatty acid a homogalacturonan branching 6-phosphate UTP--glucose- N-(arachidonoyl) sn-glycero-3- MeOH 2-yl)-L-glutamate glucosamine-1- [+ 18 isozymes] rbsD OO69_RS09615 N-monoacetylchitobiose 5'-deoxyadenosine complex H protein] N 6 an unsulfurated γ-D-glutamyl-L-lysyl-D-alanyl-D-alanine phosphoethanolamine a fatty aldehyde 1,3-dien-1-yl)propanoate phosphomannomutase/ 4-hydroxy- 1-hydroxy-2- rhamnogalacturonase L-ribulose 5- β a (1->4)-β-D-xylan met ethanolamine phosphocholine enzyme: phosphate N- 1-phosphate a 3-oxotetradecanoyl- -D-ribofuranose 6'-phosphate -[(R)-lipoyl]-L-lysine [sulfur carrier] phosphoglucomutase: 2,2'-bipyrrole- methyl-2-butenyl crotonyl-CoA B precursor: phosphate oligosaccharide β-D-fructofuranose D-glucopyranose a nascent peptidoglycan glgB acetyltransferase uridylyltransferase [RedL polyketide 6-phospho-beta- OO69_RS44200 5-methanol 4-diphosphate L-ribulose-5- xylan 1,4-beta- with (L-alanyl-γ-D-glutamyl- 1,4-alpha- GlmU: glmU GalU: galU UDP-N-acetyl- OO69_RS17320 α synthase] enoyl-CoA ROK family glucosidase: α meso-2,6-diaminopimeloyl-D- UDP-N-acetyl- -D-mannose reductase: tunicaminyl-uracil rhamnogalacturonase phosphate xylosidase: GDP-α-D- trans,octacis a lyso- 4-fumaryl- an α(1,5)- 6-O-cis-keto- 6-O- -mycolyl- glucan UTP--glucose- hydratase: glucokinase: OO69_RS17640 D-glucopyranose maltopentaose NADPH NAD + 4-hydroxybenzoate an arylamine 5-hydroxy- α 1-phosphate OO69_RS18385 4-epimerase OO69_RS42340 mannose -decaprenyl coenzyme A L-arabinan hydantoin 3-methylcatechol precorrin-6B toluene mycolyl-trehalose trehalose 6- alanyl-D-alanine) pentapeptide branching -D-glucosamine 1-phosphate 1-hydroxy-2- OO69_RS35630 B precursor: D-ribofuranose OO69_RS32360 [+ 2 isozymes] phospholipid acetoacetate L-tryptophan 4-hydroxy-2,2'- methyl-2-butenyl 4-hydroxy-3- OO69_RS26005 AraD: araD beta-xylosidase: phosphate dihydropyrimidinase: 4-hydroxybenzoate catechol 2,3- arylamine N- precorrin-6y C5,15- toluene 6-phosphate phosphate enzyme: uridylyltransferase (S)-3- ROK family N-acetyl-D-glucosamine trehalose- aromatic amino trehalose- 5-undecyl-1,2- D-xylulose ribokinase: OO69_RS40655 D-xylose fructokinase: alpha-N- hydA 3-monooxygenase: acetyltransferase: methyltransferase D-alanyl-D-alanine penicillin-binding glgB GalU: galU bipyrrole-5- 4-diphosphate methylbut-2-enyl N-acetyl- 4-deoxy-4,5-unsaturated α- 4-alpha- Si-specific NAD(P)(+) dioxygenase: monooxygenase: phosphatase: dihydropyrrol- hydroxybutanoyl-CoA OO69_RS29640 degradation I glucokinase: 6-phosphate polyprenol lysophospholipase: CoA pyrophosphatase: fumarylacetoacetase: dihydropyrimidinase: OO69_RS14465 OO69_RS21825 (decarboxylating) phosphatase: acid lyase: carboxypeptidase/ protein 2: carbaldehyde reductase: diphosphate D-galactopyranosyluronate- 5-phosphate OO69_RS06565 glucanotransferase: arabinofuranosidase: OO69_RS24410 OO69_RS08400 α α 3-one tunicaminyl-uracil β-D-xylopyranose OO69_RS06565 monophosphomannose transhydrogenase: otsB OO69_RS32105 otsB D-alanyl-D-alanine- OO69_RS39170 a mature peptidoglycan with a GlgE-glycogen GDP- -D-mannose UDP- -D-glucose OO69_RS18385 reductase: (S)-3- ribokinase: malQ OO69_RS02300 OO69_RS45910 fahA OO69_RS45160 hydA [+ 4 isozymes] (2Z,4E)-2-hydroxy-6- [+ 3 isozymes] subunit CbiE: cbiE [rhamnogalacturonan D-xylose melibiose degradation synthase: OO69_RS21510 sthA an N- trehalose-cis-keto- α, α'-trehalose γ hydroxybutanoyl- D-glucopyranose protocatechuate precorrin-8x benzyl alcohol serotonin endopeptidase: dacB [+ 4 isozymes] (L-alanyl- -D-glutamyl-meso- 4-hydroxy-3- OO69_RS43920 I oligosaccharide] rbsK xylose N-carbamoylglycine oxohepta-2,4-dienoate mono-mycolate 6-α-mycolate CoA 6-phosphate acetylarylamine [+ 2 isozymes] 2,6-diaminopimeloyl-D-alanyl- 4-methoxy- methylbut-2-enyl D-ribofuranose isomerase: trans,octacis- an α(1,5)- α-L- a nascent peptidoglycan N-acetyl-D- dehydrogeanse: melibiose maltose maltotetraose D-alanine) pentapeptide 2,2'-bipyrrole- diphosphate 5-phosphate xylA glucose-6- decaprenylphospho- a carboxylate a glycerophosphodiester NADH NADP + 3',5'-ADP 4'-phosphopantetheine acetoacetate fumarate L-arabinan arabinofuranose with D,D cross-links (meso- 2-undecylpyrrole glucosaminyl-N-acetyl- OO69_RS18220 GDP a nascent peptidoglycan 5-carbaldehyde reductase: D-xylulose phosphate β-D-mannose γ 2-O-(4-deoxy-β-L-threo- with (L-alanyl- -D-glutamyl- diaminopimelate containing) IPP tunicaminyl-uracil 3-hydroxyacyl-CoA isomerase: OO69_RS43920 hex-4-enopyranuronosyl) fructose degradation alpha-glucosidase/ meso-2,6-diaminopimeloyl- dehydrogenase: xylulokinase: pgi -α-L-rhamnopyranose alpha-galactosidase: D-alanine) tetrapeptide OO69_RS35630 β-D-fructofuranose xylB glucose-6- OO69_RS03465 a 1-acyl-2-lyso- 1-(oleoyl)-sn-glycero-3- p-nitrophenyl- a 1-acyl-sn-glycero- N-acetyl-β- an N-terminal L- 3-amino-4- isopentenyl- 1-phosphate methylmalonate semialdehyde D-glucopyranose maltohexaose a mature peptidoglycan N-acetyl-D-glucosaminyl- D-xylulose phosphate [+ 8 isozymes] β-D-galactoside neuraminate CTP alanyl-[S18 protein 4-guanidinobutyramide a folate D-ala glyoxylate benzaldehyde trp cys L,D-transpeptidase: L,D-transpeptidase: diphosphate acetoacetyl-CoA 1-phosphofructokinase: phosphatidylethanolamine phosphoethanolamine 3-phosphocholine hydroxybenzaldehyde with D,D cross-links (meso- undecylprodigiosin 5-phosphate of 30S ribosome] arylamine N- dihydrofolate Delta- tunicaminyl-uracil pfkB isomerase: ribosomal protein amidase: benzaldehyde OO69_RS10905 OO69_RS10905 β D-alanine--D- malate synthase tryptophan 7- cystathionine diaminopimelate containing) acetyl-CoA C- 4-deoxy-L-threo-hex- -D-fructose 1,6- pgi D-galactopyranose N-acylneuraminate S18-alanine N- acetyltransferase: OO69_RS04570 reductase: dehydrogenase: L,D-transpeptidase: a nascent peptidoglycan with L,D-transpeptidase: a mature peptidoglycan isomerase: idi L-rhamnopyranose D-glucopyranose 4-alpha- beta-glucosidase: acyltransferase: 4-enopyranuronate bisphosphate CoA-acylating lysophospholipase: lysophospholipase: lysophospholipase: OO69_RS21825 OO69_RS14640 alanine ligase: A: OO69_RS06695 halogenase: gamma-lyase: OO69_RS09555 (L-alanyl-γ-D-glutamyl-meso- OO69_RS09555 with (L-alanyl-γ-D-glutamyl- glucanotransferase: OO69_RS40695 cytidylyltransferase: acetyltransferase: [+ 6 isozymes] OO69_RS04060 OO69_RS35625 F6P methylmalonate- [+ 2 isozymes] OO69_RS23310 OO69_RS48410 OO69_RS39515 malQ OO69_RS02300 OO69_RS02300 OO69_RS02300 OO69_RS10465 an N-terminal N-acetyl-rimI [+ 3 isozymes] 2,6-diaminopimelate) tripeptide meso-2,6-diaminopimeloyl- semialdehyde [+ 4 isozymes] 3-acetylamino-4- 4-guanidinobutanoate (S)-malate benzoate 7-chloro-L- streptorubin B DMAPP a tunicamycin [+ 7 isozymes] a 7,8-dihydrofolate D-alanyl-D-alanine pyruvate a nascent peptidoglycan a nascent peptidoglycan D-alanine) tetrapeptide dehydrogenase: mmsA L-alanyl-[S18 protein hydroxybenzaldehyde tryptophan with L,D cross links (meso- with (L-alanyl-γ-D-glutamyl- CMP-N-acetyl- of 30S ribosome] acetyl-CoA maltose sn-glycero-3- sn-glycero-3- sn-glycero-3- diaminopimelate containing) meso-2,6-diaminopimeloyl- maltopentaose a carboxylate oleate D-galactopyranose 4-nitrophenol a carboxylate β-neuraminate a mature peptidoglycan with Carboxylate Degradation phosphoethanolamine phosphoethanolamine phosphocholine glycine) tetrapeptide + (L-alanyl-γ-D-glutamyl-meso- hydrogencarbonate NADH propanoyl-CoA H 2,6-diaminopimelate) tripeptide glycolate and propanoyl CoA pyruvate fermentation to acetate IV superpathway of acetate a mature peptidoglycan glyoxylate pyruvate decarboxylation to acetyl CoA I oxalate degradation I with L,D cross-links (meso- a mature peptidoglycan degradation II utilization and formation a [pyruvate dehydrogenase E2 a 2-acyl-1-lyso- XLXG xyloglucan D-threo-7,8- a 2-acyl-sn-glycero- a cytidine 1402 (1S,4R)-2,4,5-trichloro- (R)-3- adenosyl-cob(III) degradation I a [pyruvate D-glucopyranose a maltodextrin 7,8-dihydroneopterin chloramphenicol (S)-NADPHX (S)-NADHX citrate diaminopimelate containing) with (L-alanyl-γ-D-glutamyl- pyruvate a sulfurated [sulfur carrier] SAM protein] N 6 -octanoyl-L-lysine phosphatidylethanolamine oligosaccharide dihydroneopterin 3-phosphocholine in 16S rRNA 2,5-cyclohexadiene-1-diol hydroxybutanoate yrinate a,c-diamide trp glycolate dehydrogenase propanoyl-CoA pyruvate fermentation acetate 2',3'-cyclic phosphate meso-2,6-diaminopimeloyl- pyruvate oxalate polyprenol 16S rRNA haloalkane 3-hydroxybutyrate CatB-related O- cobyric acid NAD(P)H-hydrate NAD(P)H-hydrate aconitate 6 to acetate II acetate--CoA E2 protein] N pyruvate acyl-CoA (cytidine(1402)-2'-O) aromatic amino glycine) tetrapeptide ligase: acs 4-alpha- beta-glucosidase: phosphomannose- dehalogenase: dehydrogenase: acetyltransferase: synthase: dehydratase: dehydratase: hydratase -lipoyl-L-lysine dehydrogenase carboxylase: acetate kinase: lysophospholipase: lysophospholipase: -methyltransferase: acid lyase: pyruvate glucanotransferase: OO69_RS40695 dihydroneopterin dependent alpha 1,6 OO69_RS38555 OO69_RS01935 OO69_RS13700 OO69_RS46480 OO69_RS09530 OO69_RS09530 AcnA: acnA (acetyl- OO69_RS50295 OO69_RS37785 OO69_RS02300 rsmI OO69_RS32105 glyoxylate pyruvate oxalyl-CoA lipoyl synthase: lipA malQ OO69_RS02300 [+ 4 isozymes] aldolase: folB mannosyltransferase a 2'-O- (1S,4S)-2,5-dichloro-2,5- chloramphenicol transferring), OO69_RS23455 acetoacetate adenosylcobyrate NADPH NADH D-threo-isocitrate MptB: mptB 1402 cyclohexadiene-1,4-diol 3-acetate tryptamine glyoxylate homodimeric acetyl-CoA formate dehydrogenase: methylcytidine (S)-methylmalonyl-[+ 2 isozymes] oxalyl-CoA acetyl phosphate acetyl-CoA 7,8-dihydroneopterin carboligase: OO69_RS07180 sn-glycero-3- XXXG xyloglucan 6-(hydroxymethyl) sn-glycero-3- in 16S rRNA type: aceE decarboxylase: a maltodextrin maltose a carboxylate D-galactopyranose glycolaldehyde 2'-phosphate gcl pyruvate CoA phosphate acetyl-CoA a [pyruvate dehydrogenase oligosaccharide a carboxylate [+ 4 isozymes] OO69_RS05660 5'-deoxyadenosine phosphoethanolamine -7,8-dihydropterin phosphocholine met E2 protein] N 6 -lipoyl-L-lysine an unsulfurated [sulfur carrier] tartronate dehydrogenase: methylmalonyl- acetyltransferase: pta OO69_RS07180 a [pyruvate CoA phosphate phosphate semialdehyde a [pyruvate formyl-CoA [+ 2 isozymes] dehydrogenase epimerase: mce acetyl phosphate acetyltransferase: pta acetyltransferase: pta 2-hydroxy-3- dehydrogenase 6 E2 protein] N -S- formyl-CoA a plant soluble a long-linear 1518 1402 6 (R)-methylmalonyl- α undecaprenyl-diphospho-N XXLG xyloglucan adenine / a cytidine 4-hydroxy-3- γ-glutamyl- oxopropionate E2 protein] N - acetyl phosphate UDP-N-acetyl- -D-glucosamine D-glucopyranose a sialyloligosaccharide α-D-glucopyranose 7,8-dihydroneopterin oxaloacetate dimethylarsonite reduced riboflavin propionamide ribulose acetyldihydrolipoyl- CoA transferase: frc γ heteroglycan oligosaccharide α-D-glucan 1519 tyr reductase: dihydrolipoyl-L-lysine acetate kinase: -acetylmuramoyl-L-alanyl- - adenine in 16S rRNA 2',3'-cyclic phosphate in 16S rRNA octaprenylbenzoate isopropylamide pyruvate L-lysine OO69_RS37785 D-glutamyl-L-lysyl- D-alanine 16S rRNA 16S rRNA OO69_RS06845 methylmalonyl- polyprenol phosphoenolpyruvate arsenite UbiD family FMN reductase: ferredoxin: amidase: ribulokinase: dehydrogenase: acetate kinase: formate D-gluconate (adenine(1518)-N(6)/ (cytosine(1402)-N(4) aromatic amino CoA mutase: undecaprenyldiphospho- 4-alpha- exo-alpha-sialidase: beta-glucosidase: 4-alpha- phosphomannose- carboxykinase (GTP) methyltransferase: decarboxylase: OO69_RS22000 OO69_RS03500 OO69_RS04570 araB OO69_RS07180 acetate OO69_RS37785 degradation adenine(1519)-N(6))- )-methyltransferase acid lyase: D-glycerate OO69_RS37750 muramoylpentapeptide beta-N- glucanotransferase: OO69_RS03995 OO69_RS40695 glucanotransferase: dependent alpha 1,6 : OO69_RS36640 arsM OO69_RS13940 [+ 7 isozymes] [+ 14 isozymes] [+ 6 isozymes] dimethyltransferase RsmH: rsmH OO69_RS32105 acetylglucosaminyltransferase: malQ malQ mannosyltransferase an N 4 - phosphoenol N-(γ-L-glutamyl) L(or D)-ribulose [+ 3 isozymes] acetate D-gluconate [+ 3 isozymes] [+ 4 isozymes] trimethylarsine 2-octaprenylphenol riboflavin propanoate glycerate kinase: RsmA: rsmA 1402 p-tyramine 5-phosphate murG N 6 -dimethyladenine 1518 MptB: mptB methylcytidine pyruvate -L-alaninol OO69_RS06240 succinyl-CoA gluconokinase: 7,8-dihydroneopterin a plant soluble XXXG xyloglucan a short 1,4- /N 6 -dimethyladenine 1519 in 16S rRNA acetyl-CoA OO69_RS28505 ditrans,octacis-undecaprenyldiphospho- maltose N-acetylneuraminate an oligosaccharide D-galactopyranose 3'-phosphate 2-phospho- D-gluconate UDP heteroglycan oligosaccharide α-D-glucan in 16S rRNA N-acetyl-(N-acetylglucosaminyl)muramoyl- D-glycerate 6-phosphate L-alanyl-γ-D-glutamyl-L-lysyl-D-alanine

an [amino-group carrier protein]- UDP-N-acetyl-α-D-glucosamine undecaprenyl-diphospho-N-acetylmuramoyl-L- XLLG xyloglucan α-D-glucopyranose a uridine 55 (2R,3S)-3- uridine D-glucopyranose maltotetraose 1-aminocyclopropane- a ribonucleoside androstenedione Fe 2+ alanyl-γ-D-glutamyl-L-lysyl- D-alanyl-D-alanine 2,3-DHP oligosaccharide C-terminal-γ-(L-glutamate 5- CTP 1-phosphate methylarsonite a 3-oxosteroid methylglyoxal 1-carboxylate 5'-monophosphate in tRNA isopropylmalate uridine kinase: semialdehyde-2-yl)-L-glutamate arsenate detoxification I (mammalian) Detoxification undecaprenyldiphospho- 2,3-dihydroxyphenylpropionate N-acetyl-gamma- 1-aminocyclopropane- bifunctional tRNA arsenite 3-isopropylmalate 3-oxosteroid 1- 3-oxosteroid 1- Alcohol Degradation reactive oxygen species degradation arsenate glyoxalase: OO69_RS10610 muramoylpentapeptide beta-N- 4-alpha- 1,2-dioxygenase: beta-glucosidase: glutamyl-phosphate 1-carboxylate glucose-1-phosphate metallophosphatase/ pseudouridine(55) methyltransferase: dehydrogenase: dehydrogenase: dehydrogenase: bacterioferritin: bfr detoxification OO69_RS31730 uridine kinase: arsenate acetylglucosaminyltransferase: glucanotransferase: OO69_RS14880 OO69_RS40695 reductase: deaminase: cytidylyltransferase: 5'-nucleotidase: synthase TruB: truB arsM OO69_RS23610 OO69_RS22245 OO69_RS22245 glycerol and glycerophosphodiester degradation II (glutaredoxin) OO69_RS25370 superoxide malQ (2Z,4E)-2-hydroxy- OO69_RS20585 OO69_RS36155 a pseudouridine 55 4-methyl-2- androsta-1,4- a 3-oxo- ethanol degradation I ethanol glycerol degradation V murG [+ 4 isozymes] an [amino-group carrier protein]- OO69_RS25815 OO69_RS26665 3+ 6-oxonona-2,4- dimethylarsonite ∆ 1 (R)-lactate Fe UMP degradation II arsenate C-terminal-γ-(5-phospho- 2-oxobutanoate a ribonucleoside in tRNA oxopentanoate diene-3,17-dione -steroid purine-nucleoside arsenate superoxide dismutase: diene-1,9-dioate glycerol arsenate XXXG xyloglucan L-glutamyl)-L-glutamate ethanol glycerol phosphorylase: reductase ArsC: OO69_RS04125 ditrans,octacis-undecaprenyldiphospho-N- UDP maltose maltotriose D-galactopyranose CDP-α-D-glucose ethanol reductase ArsC: oligosaccharide ethanol OO69_RS10700 OO69_RS31235 [+ 2 isozymes] acetyl-(N-acetyl-β-D-glucosaminyl)muramoyl-L- ethanol OO69_RS31235 dehydrogenase: alanyl-γ-D-glutamyl-L-lysyl-D-alanyl-D-alanine dehydrogenase: hydrogen peroxide arsenite OO69_RS10870 dihydroxyacetone a glycerophosphodiester glycerol OO69_RS10870 ribose-1-arsenate arsenite acetaldehyde α acetaldehyde dihydroxyacetone 4a-hydroxy-L- DNA combined with a 2-O-( -D-mannosyl)-1- 3-(4- 25-hydroxycholest- (2R,3S)-3- (indol-3-yl) cholest-4- cytidine catalase: dethiobiotin a sulfurated a homogalacturonan (S)-2-hydroxyglutarate NaMN β-lindane L-cysteate (R)-lactate kinase subunit SAM erythro-5,6,7,8- exogenous DNA to form phosphatidyl-1D-myo-inositol hydroxyphenyl) 4-en-3-one isopropylmalate acetamide en-3-one glycerophosphodiester glycerol kinase acetaldehyde OO69_RS43845 arsenate [sulfur carrier] phosphatidylinositol uridine kinase: acetaldehyde DhaK: dhaK tetrahydrobiopterin a recombinational junctionHolliday junction pyruvate L-2-hydroxyglutarate bifunctional haloalkane 3-oxosteroid 1- 3-isopropylmalate amidase: aspartate 3-oxosteroid 1- D-2-hydroxyacid phosphodiesterase: GlpK: glpK dehydrogenase detoxification V arsenite mannoside OO69_RS10610 dehydrogenase: [+ 3 isozymes] 4a-hydroxytetrahydrobiopterin resolvase RuvX: ruvX 4-hydroxyphenylpyruvate oxidase: lhgO metallophosphatase/ dehalogenase: dehydrogenase: dehydratase: OO69_RS04570 transaminase: dehydrogenase: dehydrogenase: (acetylating): arsenic H O hydroxyl radical endopolygalacturonase: uridine kinase: OO69_RS22770 glycerol kinase OO69_RS08215 DHAP 2 biotin acyltransferase: L-2-hydroxyglutarate 5'-nucleotidase: OO69_RS11780 arsenate dehydratase: OO69_RS05875 crossover junction dioxygenase: hppD OO69_RS38555 OO69_RS22245 leuD leuC [+ 6 isozymes] OO69_RS29770 OO69_RS22245 OO69_RS29155 [+ 6 isozymes] GlpK: glpK triglutathione OO69_RS05055 OO69_RS20935 OO69_RS25370 O synthase α oxidase: lhgO OO69_RS36155 2,3,4,5,6- 25-hydroxycholesta- (2S)-2- cholesta-1,4- acetaldehyde acetate arsenite 2 glyceraldehyde- (6R)-L-erythro-6,7- endodeoxyribonuclease a 2-O-(6-O-acyl- -D-mannosyl)- β-D- (indol-3-yl)acetate 3-sulfopyruvate pyruvate CMP BioB: bioB homogentisate 2-oxoglutarate pentachlorocyclohexanol 1,4-dien-3-one isopropylmalate dien-3-one dehydrogenase methyltransferase: 3-phosphate dihydrobiopterin resolution of recombinationalRuvC: ruvC 1-phosphatidyl-1D-myo-inositol ribosylnicotinate sn-glycerol 3-phosphate (acetylating): acetate--CoA arsM dehydrogenase: a homogalacturonan a homogalacturonan junction formation OO69_RS07605 biotin an unsulfurated OO69_RS07810 ligase: acs 1-arseno-3- 5'-deoxyadenosine met of two intact strands dimethylarsonite [sulfur carrier] phosphoglycerate acetyl-CoA acetyl-CoA

DHAP trans,octacis-decaprenylphospho- 3-phenyl-2- a single a cytosine 967 a monocarboxylic β-D-fructose 1,6- Reactive Blue 5 seleno-L- β maltotriose a glucan uroporphyrinogen-I a cytosine in DNA dihydroxyacetone choline pyrazinamide acetamide xylan -D-arabinofuranose oxopropanoate stranded DNA in 16S rRNA acid amide bisphosphate 1-arseno-3- homocysteine decaprenylphospho-beta- cacodylate rRNA cytosine-C5- DNA cytosine amidase: choline class II fructose- amidase: amidase: alpha- phosphoglycerate 5-methyltetrahydropteroyltriglutamate- D-erythro-pentofuranosid- 4-hydroxyphenylpyruvate deoxyribonuclease uroporphyrinogen dihydroxyacetone 4-alpha- methyltransferase: methyltransferase: OO69_RS04570 dehydrogenase: bisphosphatase: OO69_RS04570 OO69_RS04570 xylosidase: Amine and Polyamine Degradation Dyp-type - homocysteine S- 2-ulose 2-reductase: dioxygenase: hppD IV: OO69_RS32430 decarboxylase: hemE kinase: dhaL dhaK glucanotransferase: OO69_RS21235 OO69_RS34060 [+ 6 isozymes] betA glpX [+ 6 isozymes] [+ 6 isozymes] yicI peroxidase: methyltransferase: metE OO69_RS10155 OO69_RS11850 trans,octacis-decaprenylphospho- malQ (2-hydroxyphenyl) a 5-methylcytosine 967 a 5-methylcytosine pyrazine-2- α-D-xylopyranose ethanolamine utilization a 5'-phosphooligonucleotide coproporphyrinogen I DHAP a monocarboxylate betaine aldehyde F6P acetate 4-aminobutanoate SeMet β-D-erythro-pentofuranosid-2-ulose acetate in 16S rRNA in DNA carboxylate superpathway of 4- putrescine degradation IV allantoin degradation putrescine degradation I urea degradation II aminobutanoate degradation degradation III to ureidoglycolate II 2,2'-disulfonyl 3-[(4-amino-6-chloro- a glucan D-glucopyranose ethanolamine phthalate putrescine (ammonia producing) urea azobenzene 1,3,5-triazin-2-yl) 4-aminobutanoate putrescine 4-aminobutanoate ethanolamine urease: amino]benzenesulfonate 4-aminobutyrate- (S)-(+)-allantoin 4-aminobutyrate- ammonia-lyase: OO69_RS23580 -2-oxoglutarate allantoinase -2-oxoglutarate OO69_RS34535 eutC ureA 10 α-D-galacturonosyl- transaminase: AllB: allB 4-aminobutanal transaminase: 3-methyl-2- 5,10-methylene- 6-[1-hydroxyethyl]-7- 4a-hydroxy-N - α (R)-10- isoprimeverose (1->4)-α-D-galacturonate uroporphyrinogen-III protoporphyrinogen IX an -limit dextrin 2-hydroxyisobutyramide a kanamycin a chitodextrin L-fuconate cellulose chitosan D-glucopyranose gabT allantoate urease: oxobutanoate tetrahydromethanopterin methyl-7,8-dihydropterin formyltetrahydrofolate Hydroxystearate acetaldehyde succinate 4-aminobutanal succinategabT gamma- OO69_RS00110 2-amino-4-hydroxy-6- 4-alpha- amidase: aminoglycoside chitinase: L-fuconate endo-1,4-beta- chitosanase: xylose semialdehyde semialdehyde 4a-hydroxytetrahydrobiopterin endopolygalacturonase: uroporphyrinogen protoporphyrinogen oleate hydratase: allantoate aminobutyraldehyde OO69_RS00115 3-methyl-2-oxobutanoate hydroxymethyldihydropteridine glucanotransferase: OO69_RS04570 phosphotransferase: OO69_RS22955 dehydratase: glucanase: OO69_RS12240 isomerase: dehydratase: OO69_RS05875 alpha- OO69_RS05055 decarboxylase: hemE oxidase: hemG OO69_RS13740 acetaldehyde ethanol NAD-dependent gamma- amidohydrolase: dehydrogenase: OO69_RS00120 hydroxymethyltransferase: diphosphokinase: folK malQ [+ 6 isozymes] OO69_RS17300 [+ 6 isozymes] OO69_RS04475 OO69_RS35010 [+ 2 isozymes] xylA xylosidase: yicI α succinate- succinate- [1-(2-amino-7-methyl-4-oxo- 10 a -limit dextrin a kanamycin N,N'- 2-dehydro-3- a chitosan dehydrogenase dehydrogenase: aminobutyraldehyde OO69_RS32150 OO69_RS22965 ammonium panB an N -formyl- D-galactopyranuronate 2-hydroxy-2- a cellodextrin keto-D-fructose semialdehyde semialdehyde coproporphyrinogen III protoporphyrin IX with short branches 3'-phosphate oleate diacetylchitobiose deoxy-L-fuconate fragment (acetylating): OO69_RS10870 dehydrogenase: gamma- 7,8-dihydro-3H-pteridin- 7,8-dihydrofolate methylpropanoate dehydrogenase: dehydrogenase 1-pyrroline (S)-ureidoglycine succinate 6-yl)]ethyl diphosphate OO69_RS11780 OO69_RS22965 aminobutyraldehyde α OO69_RS27805 (NADP(+)): D-glucopyranose -D-xylopyranose acetaldehyde gamma- dehydrogenase: 2-dehydropantoate THMPT ethanol OO69_RS09775 dehydrogenase NAD-dependent aminobutyraldehyde OO69_RS34890 (acetylating): succinate- dehydrogenase: 4-aminobutanoate OO69_RS07810 semialdehyde OO69_RS34890 (S)-ureidoglycolate allantoin degradation dehydrogenase: to ureidoglycolate OO69_RS24455 acetyl-CoA 4-aminobutanoate I (urea producing) succinate (S)-(+)-allantoin phosphate allantoinase acetyltransferase: pta AllB: allB allantoate acetyl phosphate allantoicase: acetate kinase: alc OO69_RS37785 (S)-ureidoglycolate acetate a reduced a branched- chain plastocyanin a reduced amino acid an oxidized plastocyanin (2-aminoethyl) glycine betaine glycine betaine a carbohydrate a carbohydrate a carbohydrate plastocyanin an oxidized phosphonate lipid II (meso an inorganic an inorganic an inorganic an inorganic an inorganic an an an an spermidine a sugar 6- a sugar 6- sn-glycerol N-acetyl-α-D-glucosamine α-L- an aliphatic an aromatic a C4- D-fructose D-glucose 6- glutamate a nicotinamide a quaternary pro pro a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate ammonium ammonium ammonium D-gluconate diaminopimelate a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate anion oligopeptide plastocyanin 3-phosphate carboxylate dicarboxylate 1-phosphate mononucleotide ammonium anion anion anion anion oligopeptide oligopeptide oligopeptide putrescine phosphate phosphate N,N'-diacetylchitobiose rhamnopyranose sulfonate predicted phosphate choline choline containing) compound ABC predicted ABC predicted ABC predicted ABC predicted ABC cbb3-type transporter transporter of RS02730 RS21710 RS33200 RS21390 SugE RS40900 RS03875 FtsW RS25840 RS25910 RS40795 RS33220 RS17615 RS17780 RS17900 RS25085 transporter of transporter of transporter of RS16635 RS09595 RS39810 RS30615 RS17040 RS17260 RS17410 RS03460 RS10920 RS04520 RS11430 RS11030 RS05165 RS51550 RS20860 RS11180 RS21440 RS22495 RS00765 RS07310 RS44480 RS35710 RS07380 RS26320 RS26440 RS07555 RS26610 RS34970 RS12265 RS07920 RS19970 RS12470 RS32075 RS47865 RS45940 RS35440 RS33440 RS27570 RS27015 RS14005 cytochrome CoxB RS34895 RS23170 RS40670 RS24210 RS39025 RS44225 UgpC RS28500 NgcE RhaS RS17100 RS24415 of a RS09860 (2-aminoethyl) a carbohydrate a carbohydrate a carbohydrate c oxidase branched- phosphonate α α chain an inorganic an inorganic an inorganic an inorganic an inorganic an an an an spermidine sn-glycerol N-acetyl- -D-glucosamine -L- an aliphatic an aromatic a C4- a nicotinamide glycine betaine glycine betaine a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate ammonium ammonium ammonium a sugar a sugar D-gluconate amino acid D-fructose D-glucose a quaternary lipid II (meso anion anion anion anion oligopeptide oligopeptide oligopeptide oligopeptide putrescine N,N'-diacetylchitobiose rhamnopyranose sulfonate dicarboxylate glutamate mononucleotide pro pro a carbohydrate a carbohydrate a carbohydrate anion O 3-phosphate carboxylate diaminopimelate 2 (2-aminoethyl) ammonium choline choline containing) O H O phosphonate compound 2 2 a branched- H O 2 chain amino acid This diagram was automatically generated by SRI International Pathway Tools version 25.0, authors S. Paley and P.D. Karp.