W&M ScholarWorks Dissertations, Theses, and Masters Projects Theses, Dissertations, & Master Projects 2013 Total Synthesis of (+)-Malbrancheamide B Utilizing a Stereoselective Domino Reaction Sequence to Establish the Bicyclo[2.2]diazaoctane Core Stephen William Laws College of William & Mary - Arts & Sciences Follow this and additional works at: https://scholarworks.wm.edu/etd Part of the Organic Chemistry Commons Recommended Citation Laws, Stephen William, "Total Synthesis of (+)-Malbrancheamide B Utilizing a Stereoselective Domino Reaction Sequence to Establish the Bicyclo[2.2]diazaoctane Core" (2013). Dissertations, Theses, and Masters Projects. Paper 1539626719. https://dx.doi.org/doi:10.21220/s2-rk6n-w245 This Thesis is brought to you for free and open access by the Theses, Dissertations, & Master Projects at W&M ScholarWorks. It has been accepted for inclusion in Dissertations, Theses, and Masters Projects by an authorized administrator of W&M ScholarWorks. For more information, please contact
[email protected]. Total synthesis of (+)-malbrancheamide B utilizing a stereoselective domino reaction sequence to establish the bicyclo[2.2.2]diazaoctane core Stephen William Laws Richmond, VA Bachelor of Science, College of William and Mary, 2011 A Thesis presented to the Graduate Faculty of the College of William and Mary in Candidacy for the Degree of Master of Science Chemistry Department The College of William and Mary August, 2013 APPROVAL PAGE This Thesis is submitted in partial fulfillment of the requirements for the degree of Master of Science Stephen William Laws Approved by thei^qmmittee, 07/2013 Committee Chair Assistant Professor Jonathan Scheerer, Chemistry The College of William and Mary ^ e S iA ^ G O K g y---- Professor Deborah Bebout, Chemistry The College of William and Mary / jProfessor Robert Hinkle, Chernrstry ' TheTho CollegePrkllono nfof \A/flliamWilliam anrland Mary Marx/ ABSTRACT The total enantioselective and formal racemic syntheses of malbrancheamide B, a bicyclo[2.2.2]diazaoctane-containing fungal metabolite are described.