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Healing with Hallucinogens the Therapeutic Benefits of Psychedelic Drugs

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Healing with Hallucinogens the Therapeutic Benefits of Psychedelic Drugs SEPTEMBER 2017 | WWW.THE-SCIENTIST.COM HEALING WITH HALLUCINOGENS THE THERAPEUTIC BENEFITS OF PSYCHEDELIC DRUGS DO MICROBES TRIGGER ALZHEIMER’S? THE FUNCTIONAL CONSEQUENCES OF DNA BASE MODIFICATIONS TAKING KIDS TO CONFERENCES PLUS WEANING STEM CELLS FROM FEEDER LAYERS NUMBER ONE FOR: DEPENDABILITY DATA INTEGRITY EASE OF USE No other name is as trusted as BioTek to bring you affordability without compromising performance. Learn more. Visit www.biotek.com/readerwasher. ISO certified and FDA registered for highest quality standards. REGISTER FOR FREE TO RECEIVE The Scientist’s website OUR DAILY E-NEWSLETTER features award-winning life science news coverage you won’t fi nd in the magazine, as well as features, profi les, scientist-written opinions, and spectacular videos, slide shows, and infographics. www.the-scientist.com be INSPIRED drive DISCOVERY stay GENUINE Even more from less for RNA. ® ™ NEBNext Ultra II RNA NEBNext Ultra II Directional RNA produces the highest yields, Library Prep Kits for NGS from a range of input amounts 2,000 NEBNext® Ultra™ II Directional RNA ® 1,800 Kapa Stranded Kapa HyperPrep Do you need increased sensitivity and specificity ® ® 1,600 Illumina TruSeq Stranded from your RNA-seq experiments? Do you have 1,400 ever-decreasing amounts of input RNA? 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SEPTEMBER 2017 Contents THE SCIENTIST THE-SCIENTIST.COM VOLUME 31 NUMBER 9 STAFF Features ON THE COVER: © JAMES WORRELL/GETTY IMAGES SCIENTIST THE 34 42 48 Trippy Treatments Brain Bugs DNA Extras Scientists are beginning to unravel Long relegated to the scientific fringe, Researchers are just beginning the mechanisms behind the therapeutic the idea that infection may trigger to scratch the surface of how several KIMBERLY BATTISTA; KIMBERLY effects of psychedelic drugs. some cases of Alzheimer’s disease newly recognized DNA modifications © BY DIANA KWON is gaining traction. function in the genome. BY JILL U. ADAMS BY SKIRMANTAS KRIAUCIONIS SEAN McCABE; © 09.2017 | THE SCIENTIST 3 BioResearch What if... … I could get more donors for my cells? … I could get expert tech support with the cells I buy? … my selfie from last night’s party gets a million “likes”? Solving Today’s Primary Cell Culture Challenges For more than 30 years, researchers have been relying on Lonza for consistent product quality and excellent support to overcome their cell culture challenges. We can’t help you get a million likes, but we can help you get cells from different donors, develop a new 3D model, or set up a co-culture. By partnering with Lonza for primary cells, you get access to: –A brand well-recognized by leading scientific journals – Over 20 donors for many cell types, including normal and diseased cells –Optimized growth media for each cell type – User-friendly protocols and publications – A scientific support team cross-trained in cells, media and 3D culture Skeletal Muscle Cells and Media Learn the benefits of primary cells. Request a free copy of our infographic on our website. ©2017 Lonza. All trademarks belong to Lonza or its affiliates. The information contained herein is believed to be correct. No warranty is made, either expressed or implied. www.lonza.com/primarycells SEPTEMBER 2017 Department Contents 13 FROM THE EDITOR 64 LAB TOOLS Far-Out Science Ready, Set, Grow How psychedelic drugs and How to culture stem cells without infectious microbes alter depending on mouse feeder cells brain function BY AMBER DANCE BY MARY BETH ABERLIN 67 CAREERS 17 NOTEBOOK Baby on Board Metropollen; Sweat Shirt; Athletic Many scientific conferences offer Prosthetics; Marshalling Microbes child care options that allow researchers to bring their families 29 CRITICS AT LARGE along for the trip. Dealing with Rising Publication BY KERRY GRENS Costs 33 As article processing charges top 70 READING FRAMES $5,000 at some research journals, CRISPRing Mammoths authors and institutions have means Can the latest gene-editing tools 60 of negotiating better deals or finding help researchers bring extinct species less expensive options. back to life? BY M. BISHR OMARY AND BY BRITT WRAY THEODORE S. LAWRENCE 76 FOUNDATIONS 33 MODUS OPERANDI Discovery of the Malaria Parasite, Bubbles for Broken Bones 1880 Ultrasound-stimulated microbubbles BY SHAWNA WILLIAMS enable gene delivery to fix fractures. BY RUTH WILLIAMS IN EVERY ISSUE 55 THE LITERATURE 11 CONTRIBUTORS Asymmetric distribution of endosomes during cell division; 14 SPEAKING OF SCIENCE an adenosine receptor for olfaction in fish; immune receptors in the 71 THE GUIDE 64 mouse nose 73 RECRUITMENT 60 PROFILE Motor Man BRYAN SATALINO BRYAN Ron Vale has spent a career studying © how molecular motors transport cargo within cells. He’s also developed tools to help scientists CORRECTIONS: communicate their findings. In the July/August issue of The Scientist, please note the following corrections: “Bacteriophages to the Rescue” stated that Shigella was a BY ANNA AZVOLINSKY virus. It is a species of bacteria. “Identifying Predatory Publishers” failed to state that Virginia Barbour’s term as chair of the nonprofit Committee on Publication Ethics (COPE) ended in May 2017. “Oceans’ Ambassador” 63 SCIENTIST TO WATCH incorrectly stated that the National Science Board (NSB) is associated with the National Academy of Sciences. The NSB is associated with the Kate Rubins: Astrovirologist National Science Foundation. “The Mechanobiology Garage” incorrectly stated that pore sizes in the microfluidic device designed by the BY AGGIE MIKA Lammerding lab did not reflect actual capillary pore sizes. They do. 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