4 the Psychedelic Landscape

Total Page:16

File Type:pdf, Size:1020Kb

4 the Psychedelic Landscape University of Plymouth PEARL https://pearl.plymouth.ac.uk 04 University of Plymouth Research Theses 01 Research Theses Main Collection 2011 Communicating the Unspeakable: Linguistic Phenomena in the Psychedelic Sphere Slattery, Diana R. http://hdl.handle.net/10026.1/549 University of Plymouth All content in PEARL is protected by copyright law. Author manuscripts are made available in accordance with publisher policies. Please cite only the published version using the details provided on the item record or document. In the absence of an open licence (e.g. Creative Commons), permissions for further reuse of content should be sought from the publisher or author. 3 Author's Declaration At no time during the registration for the degree of Doctor of Philosophy has the author been registered for any other University award without prior agreement of the Graduate Committee. This study was self-financed. Relevant scientific seminars and conferences were regularly attended at which work was often presented; several papers were prepared for publication. These are listed in Appendix IV. Word count of main body of thesis: 87, 322. Signed l'>^!:f:ffif:?:^...^.! Date ..Zl..d^^$:^..^.±LL COMMUNICATING THE UNSPEAKABLE: LINGUISTIC PHENOMENA IN THE PSYCHEDELIC SPHERE by DIANA REED SLATTERY A thesis submitted to the University of Plymouth in partial fulfillment for the degree of DOCTOR OF PHILOSOPHY Planetary Collegium Faculty of Arts AUGUST 2010 Copyright Statement This copy of the thesis has been supplied on Condition that any one who consults it is understood to recognize that its copyright rests with its author and that no quotation from the thesis and no information derived from it may be published without the author's prior consent. COMMUNICATING THE UNSPEAKABLE: LINGUISTIC PHENOMENA IN THE PSYCHEDELIC SPHERE by DIANA REED SLATTERY A thesis submitted to the University of Plymouth in partial fulfillment for the degree of DOCTOR OF PHILOSOPHY Planetary Collegium Faculty of Arts AUGUST 2010 Abstract Psychedelics can enable a broad and paradoxical spectrum of linguistic phenomena from the unspeakability of mystical experience to the eloquence of the songs of the shaman or curandera. Interior dialogues with the Other, whether framed as the voice of the Logos, an alien download, or communion with ancestors and spirits, are relatively common. Sentient visual languages are encountered, their forms unrelated to the representation of speech in natural language writing systems. This thesis constructs a theoretical model of linguistic phenomena encountered in the psychedelic sphere for the field of altered states of consciousness research (ASCR). The model is developed from a neurophenomenological perspective, especially the work of Francisco Varela, and Michael Winkelman's work in shamanistic ASC, which in turn builds on the biogenetic structuralism of Charles Laughlin, John McManus, and Eugene d'Aquili. Neurophenomenology relates the physical and functional organization of the brain to the subjective reports of lived experience in altered states as mutually informative, without reducing consciousness to one or the other. Consciousness is seen as a dynamic multistate process of the recursive interaction of biology and culture, thereby navigating the traditional dichotomies of objective/subjective, body/mind, and inner/outer realities that problematically characterize much of the discourse in consciousness studies. The theoretical work of Renaissance scholar Stephen Farmer on the evolution of syncretic and correlative systems and their relation to neurobiological structures provides a further framework for the exegesis of the descriptions of linguistic phenomena in first-person texts of long-term psychedelic self- exploration. Since the classification of most psychedelics as Schedule I drugs, legal research came to a halt; self-experimentation as research did not. Scientists such as Timothy Leary and John Lilly became outlaw scientists, a social aspect of the "unspeakability" of these experiences. Academic ASCR has largely side-stepped examination of the extensive literature of psychedelic self- exploration. This thesis examines aspects of both form and content from these works, focusing on those that treat linguistic phenomena, and asking what these linguistic experiences can tell us about how the psychedelic landscape is constructed, how it can be navigated, interpreted, and communicated within its own experiential field, and communicated about to make the data accessible to inter-subjective comparison and validation. The methodological core of this practice-based research is a technoetic practice as defined by artist and theoretician Roy Ascott: the exploration of consciousness through interactive, artistic, and psychoactive technologies. The iterative process of psychedelic self-exploration and creation of interactive software defines my own technoetic practice is the means by which I examine my states of consciousness employing the multidimensional visual language Glide. Table of Contents Abstract 5 Table of Contents 6 1 Table of Figures 10 2 Acknowledgements 13 3 Author's Declaration 15 1. Introduction 16 3.1 The Research Climate 16 3.1.1 The Academic Discourse on Consciousness 18 3.1.2 The Unspeakability of Anomalous Experience 19 3.1.3 The Ineffability Standard 20 3.1.4 The Unspeakably Aw(e)ful 23 3.1.5 Secrecy 24 3.1.6 Pragmatic Approach to Definitions of Language 24 3.2 Research Question 26 3.2.1 Neurobiological Models 27 3.3 The Appendices 29 4 The Psychedelic Field and Its Literature 31 4.1 A Divided Field 31 4.2 Literature Review 35 4.2.1 Consciousness Studies 35 4.2.2 Phenomenological Perspectives 39 4.2.3 Altered States of Consciousness Research (ASCR) 40 4.2.4 Anthropological Accounts of the Psychedelic Sphere 43 4.2.5 Cultural History of Psychedelics 44 4.2.6 The Literature of Psychedelic Self-Exploration 45 5 Methods 47 5.1 A Transdisciplinary Stance 48 5.1.1 Subjectivity/Objectivity 48 5.1.2 Nicolescu and Transdisciplinarity 51 5.2 Varela and the Calculus of Self-Reference 54 5.3 The Thesis It/Self: Self-Reflexivity 55 5.4 A Technoetic Practice 57 5.4.1 Technoetic Practice and Language 62 5.5 First Person Reports 64 5.5.1 Research Data: the AUen Downloads 71 6 The Psychedelic Landscape 75 6.1 Reality Reviewed 75 6.2 Hallucination 82 6.3 Extended Perception 83 6.3.1 Synaesthesia 89 6.3.2 Crystal Vision 92 6.3.3 High Resolution 94 6.3.4 Filaments 95 6.3.5 Hyperconnectivity 97 6.3.6 Hyperconductivity 99 6.4 Dimensionality 100 6.4.1 The Dimensions of Dimension 101 6.4.2 Fractal Dimensions 106 7 Neurophenomenological Perspectives on Language Ill 7.1 The Symbol and the Symbolic Process: Laughlin, McManus, D'Aquili Ill 7.1.1 Conscious Network 112 7.1.2 TheSensorium 112 7.1.3 The Primary Units of Experience: Dots 113 7.1.4 Symbols and the Symbolic Process 116 7.1.5 Semiosis 117 7.1.6 Evolution of the Symbolic Process 117 7.1.7 Evolution of Symbolic Forms 118 7.1.8 The Universal Symbol 121 7.1.9 Symbolic Penetration 122 7.2 Psychointegration: Winkelman 123 7.3 Presentational and Representational Symbolic Cognition: Hunt 124 7.4 Biologic: Varela 128 7.5 Correlative Systems: Farmer 136 7.6 Summary 140 8 Xenolinguistics 143 8.1 Novel Linguistic Forms 143 8.2 Language in the Warp 147 8.2.1 Effects on Natural Language '. 147 8.2.2 Eloquence 151 8.2.3 Glossolalia 152 8.3 Evolution of Language 153 8.3.1 Prehistory 154 8.3.2 Media 158 8.3.3 Language, Culture, Nature 161 8.3.4 The Call for New Language 165 8.3.5 Constructing Languages 167 8.3.6 Sensory Modalities of Xenolinguistic Presentation 168 8.4 The I Ching and Correlative Systems 172 8.4.1 I Ching as correlative system 173 8.5 The Idea of a Living Language 176 8.5.1 Panspermia 179 8.5.2 The Rainbow Serpent 182 8.6 The Xenolinguists 184 8.7 Jason Tucker: Actual Contact 184 8.7.1 Allyson Grey: Secret Writing 188 8.8 Terence and Dennis McKenna: Timewave Zero 191 8.8.1 The Experiment at La Chorrera 192 8.8.2 The Philosopher's Stone, Translinguistic Matter, and the Hyperdimensional Object at the End of Time 196 8.8.3 Timewave Zero, the Novelty Principle, and 2012 199 8.8.4 Dimensionality 205 8.8.5 Language and the Structure of Reality 206 8.8.6 Ethical Dimensions of Timewave Zero 208 8.9 Diana Slattery: Glide 210 8.9.1 The Bright Trauma 211 8.9.2 Glide Mythology 212 8.9.3 Software 220 8.9.4 The Idea of a Visual Language 220 8.9.5 Forms '. 225 8.9.6 Semantics 228 8.9.7 Logic 235 8.9.8 Uses 238 8.9.9 Ethical Dimensions of Glide 242 9 Conclusions 245 9.1 The Psychedelic Field and Its Literature 245 9.2 Methods 246 9.3 The Psychedelic Landscape 2 47 9.4 Neurophenomenology 250 9.4.1 Conscious network 251 9.4.2 TheSensorium 252 9.4.3 Dots and Waves 252 9.4.4 The Symbol 253 9.4.5 The Universal Symbol 253 9.4.6 The Matter of Correlation 254 9.5 Xenolinguistics 256 9.5.1 Contact With The Other 256 9.5.2 Natural Language, and the Evolution of Language and Consciousness 259 9.5.3 TheEschaton 261 9.6 Contribution to New Knowledge 263 9.7 Future Research 265 10 References 267 11 Appendix I: Illustrations 279 12 Appendix II 325 13 Appendix III 327 14 Appendix IV: Contact with the Other—Knowledge Acquisition in the Psychedelic Sphere , , 331 14.1 The Noetic 331 14.2 Epistemological Rupture 333 14.3 Neurobiology and Knowing 334 14.4 Self and Other 337 14.5 Transformations of Self and Other 339 14.6 The Other as Alien 345 14.7 Ego-dissolution 351 14.8 Protocols for Knowledge Acquisition Between Phases of Consciousness 356 14.9 The Technoetic Practice 359 15 Appendix V: The Technoetic Practice, History and Protocols 361 15.1 The Download Experience and the ADs 361 15.2 Protocols in Personal Practice 365 15.2.1 Initiation of the Relationship with the Other 369 15.2.2 A Spectrum of Transpersonalities 372 15.2.3 School ...376 15.2.4 Elrond 378 16 Appendix VI: Extended Perception as Alien Art 382 8 17 Appendix VII: Constructed Language Practices 389 18 Appendix VIII: The Xenolinguists 395 19 Appendix X: Bibliography 402 1 Table of Figures Figure 1.
Recommended publications
  • Inclusion of People of Color in Psychedelic-Assisted Psychotherapy
    Michaels et al. BMC Psychiatry (2018) 18:245 https://doi.org/10.1186/s12888-018-1824-6 RESEARCH ARTICLE Open Access Inclusion of people of color in psychedelic- assisted psychotherapy: a review of the literature Timothy I. Michaels1* , Jennifer Purdon1,2, Alexis Collins1 and Monnica T. Williams1,2 Abstract Background: Despite renewed interest in studying the safety and efficacy of psychedelic-assisted psychotherapy for the treatment of psychological disorders, the enrollment of racially diverse participants and the unique presentation of psychopathology in this population has not been a focus of this potentially ground-breaking area of research. In 1993, the United States National Institutes of Health issued a mandate that funded research must include participants of color and proposals must include methods for achieving diverse samples. Methods: A methodological search of psychedelic studies from 1993 to 2017 was conducted to evaluate ethnoracial differences in inclusion and effective methods of recruiting peopple of color. Results: Of the 18 studies that met full criteria (n = 282 participants), 82.3% of the participants were non-Hispanic White, 2.5% were African-American, 2.1% were of Latino origin, 1.8% were of Asian origin, 4.6% were of indigenous origin, 4.6% were of mixed race, 1.8% identified their race as “other,” and the ethnicity of 8.2% of participants was unknown. There were no significant differences in recruitment methodologies between those studies that had higher (> 20%) rates of inclusion. Conclusions: As minorities are greatly underrepresented in psychedelic medicine studies, reported treatment outcomes may not generalize to all ethnic and cultural groups.
    [Show full text]
  • Basic Hypothesis and Therapeutics Targets of Depression: a Review
    ISSN: 2641-1911 DOI: 10.33552/ANN.2021.10.000738 Archives in Neurology & Neuroscience Review Article Copyright © All rights are reserved by Anil Kumar Basic Hypothesis and Therapeutics Targets of Depression: A Review Monika Kadian, Hemprabha Tainguriya, Nitin Rawat, Varnika Chib, Jeslin Johnson and Anil Kumar* Pharmacology Division, University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Study, Panjab University, Chandigarh 160014, India *Corresponding author: Dr. Anil Kumar, PhD, Professor of Pharmacology, Phar- Received Date: May 11, 2021 macology division, University Institute of Pharmaceutical Sciences, Panjab Univer- sity, Chandigarh 160014, India. Published Date: June 07, 2021 Abstract Depression is a psychological disorder marked by emotional symptoms such as melancholy, anhedonia, distress mood, loss of interest in daily life activities, feeling of worthlessness, sleep disturbances and destructive tendencies. According to WHO, more than 264 million people from all randomage groups processes are suffering during with brain depression development. thus, Depression it is become is mainlya leading due cause to neurotransmitter of disability and imbalances, infirmity worldwide. HPA disturbances, It is estimated increased that oxidative 40% of riskand nitrosativefor depression damage, is genetic impairment and the in other glucose 60% metabolism, is non-genetic and whichmitochondrial involved dysfunction, acute & chronic etc. The stress, monoamine childhood hypothesis trauma, viral is based infections on attenuation and even of monoamines such as serotonin (5-HT), norepinephrine (NE) and dopamine (DA) in the brain regions (hippocampus, limbic system and frontal cortex) that can cause depression like symptoms. Depression is also marked by increased level of corticotrophin-releasing hormone (CRH) and and impaired responsiveness to glucocorticoid hormone.
    [Show full text]
  • Qisar-Alexander-Ollongren-Astrolinguistics.Pdf
    Astrolinguistics Alexander Ollongren Astrolinguistics Design of a Linguistic System for Interstellar Communication Based on Logic Alexander Ollongren Advanced Computer Science Leiden University Leiden The Netherlands ISBN 978-1-4614-5467-0 ISBN 978-1-4614-5468-7 (eBook) DOI 10.1007/978-1-4614-5468-7 Springer New York Heidelberg Dordrecht London Library of Congress Control Number: 2012945935 © Springer Science+Business Media New York 2013 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, speci fi cally the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on micro fi lms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied speci fi cally for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a speci fi c statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use.
    [Show full text]
  • Peakal: Protons I Have Known and Loved — Fifty Shades of Grey-Market Spectra
    PeakAL: Protons I Have Known and Loved — Fifty shades of grey-market spectra Stephen J. Chapman* and Arabo A. Avanes * Correspondence to: Isomer Design, 4103-210 Victoria St, Toronto, ON, M5B 2R3, Canada. E-mail: [email protected] 1H NMR spectra of 28 alleged psychedelic phenylethanamines from 15 grey-market internet vendors across North America and Europe were acquired and compared. Members from each of the principal phenylethanamine families were analyzed: eleven para- substituted 2,5-dimethoxyphenylethanamines (the 2C and 2C-T series); four para-substituted 3,5-dimethoxyphenylethanamines (mescaline analogues); two β-substituted phenylethanamines; and ten N-substituted phenylethanamines with a 2-methoxybenzyl (NBOMe), 2-hydroxybenzyl (NBOH), or 2,3-methylenedioxybenzyl (NBMD) amine moiety. 1H NMR spectra for some of these compounds have not been previously reported to our knowledge. Others have reported on the composition of “mystery pills,” single-dose formulations obtained from retail shops and websites. We believe this is the first published survey of bulk “research chemicals” marketed and sold as such. Only one analyte was unequivocally misrepresented. This collection of experimentally uniform spectra may help forensic and harm-reduction organizations identify these compounds, some of which appear only sporadically. The complete spectra are provided as supplementary data.[1] Keywords: 1H NMR, drug checking, grey markets, research chemicals, phenylethanamines, N-benzyl phenylethanamines, PiHKAL DOI: http://dx.doi.org/10.16889/isomerdesign-1 Published: 1 August 2015 Version: 1.03 “Once you get a serious spectrum collection, Nevertheless, an inherent weakness of grey markets is the the tendency is to push it as far as you can.”1 absence of regulatory oversight.
    [Show full text]
  • 50. Down the Rabbit Hole with Mitch Schultz, Part 1 Recorded on 12Th August, 2019 in Byron Bay, Australia
    50. Down the Rabbit Hole with Mitch Schultz, Part 1 Recorded on 12th August, 2019 in Byron Bay, Australia. With Special Guest, Mitch Schultz. Future Sense is a podcast edited from the radio show of the same name, broadcast on BayFM in Byron Bay, Australia, at www.bayfm.org. Hosted by Nyck Jeanes and well-known international futurist, Steve McDonald, Future Sense provides a fresh, deep analysis of global trends and emerging technologies. How can we identify the layers of growth personally, socially and globally? What are the signs missed; the truths being denied? Political science, history, politics, psychology, ancient civilisations, alien contact, the new psychedelic revolution, cryptocurrency and other disruptive and distributed technologies, and much more. This is Future Sense. Nyck: You're now tuned to Future Sense with myself, Nyck Jeanes, and my co-host Steve McDonald. Good morning, Steve. Steve: Good morning, Nyck. Nyck: And it's a great pleasure to welcome back to the studio—and we just worked it out, it's been like a year and a half—our friend Mitch Schulz from the US, the Texan Elf. Mitch: Thanks for having me back, guys. Steve: Welcome back, Mitch. Nyck: It's great to have you back here. You've just arrived from Austin, Texas. Mitch: I have, and always great to be back here. I look forward to a little bit of time with you guys. Stuff's happening. 1 This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ Nyck: A bit of a sketch before we play the first track, of what we're going to be doing today.
    [Show full text]
  • Programme & Abstracts
    The 57th Annual Meeting of the International Association of Forensic Toxicologists. 2nd - 6th September 2019 BIRMINGHAM, UK The ICC Birmingham Broad Street, Birmingham B1 2EA Programme & Abstracts 1 Thank You to our Sponsors PlatinUm Gold Silver Bronze 2 3 Contents Welcome message 5 Committees 6 General information 7 iCC maps 8 exhibitors list 10 Exhibition Hall 11 Social Programme 14 opening Ceremony 15 Schedule 16 Oral Programme MONDAY 2 September 19 TUESDAY 3 September 21 THURSDAY 5 September 28 FRIDAY 6 September 35 vendor Seminars 42 Posters 46 oral abstracts 82 Poster abstracts 178 4 Welcome Message It is our great pleasure to welcome you to TIAFT Gala Dinner at the ICC on Friday evening. On the accompanying pages you will see a strong the UK for the 57th Annual Meeting of scientific agenda relevant to modern toxicology and we The International Association of Forensic thank all those who submitted an abstract and the Toxicologists Scientific Committees for making the scientific programme (TIAFT) between 2nd and 6th a success. Starting with a large Young Scientists September 2019. Symposium and Dr Yoo Memorial plenary lecture by Prof Tony Moffat on Monday, there are oral session topics in It has been decades since the Annual Meeting has taken Clinical & Post-Mortem Toxicology on Tuesday, place in the country where TIAFT was founded over 50 years Human Behaviour Toxicology & Drug-Facilitated Crime on ago. The meeting is supported by LTG (London Toxicology Thursday and Toxicology in Sport, New Innovations and Group) and the UKIAFT (UK & Ireland Association of Novel Research & Employment/Occupational Toxicology Forensic Toxicologists) and we thank all our exhibitors and on Friday.
    [Show full text]
  • Hergé and Tintin
    Hergé and Tintin PDF generated using the open source mwlib toolkit. See http://code.pediapress.com/ for more information. PDF generated at: Fri, 20 Jan 2012 15:32:26 UTC Contents Articles Hergé 1 Hergé 1 The Adventures of Tintin 11 The Adventures of Tintin 11 Tintin in the Land of the Soviets 30 Tintin in the Congo 37 Tintin in America 44 Cigars of the Pharaoh 47 The Blue Lotus 53 The Broken Ear 58 The Black Island 63 King Ottokar's Sceptre 68 The Crab with the Golden Claws 73 The Shooting Star 76 The Secret of the Unicorn 80 Red Rackham's Treasure 85 The Seven Crystal Balls 90 Prisoners of the Sun 94 Land of Black Gold 97 Destination Moon 102 Explorers on the Moon 105 The Calculus Affair 110 The Red Sea Sharks 114 Tintin in Tibet 118 The Castafiore Emerald 124 Flight 714 126 Tintin and the Picaros 129 Tintin and Alph-Art 132 Publications of Tintin 137 Le Petit Vingtième 137 Le Soir 140 Tintin magazine 141 Casterman 146 Methuen Publishing 147 Tintin characters 150 List of characters 150 Captain Haddock 170 Professor Calculus 173 Thomson and Thompson 177 Rastapopoulos 180 Bianca Castafiore 182 Chang Chong-Chen 184 Nestor 187 Locations in Tintin 188 Settings in The Adventures of Tintin 188 Borduria 192 Bordurian 194 Marlinspike Hall 196 San Theodoros 198 Syldavia 202 Syldavian 207 Tintin in other media 212 Tintin books, films, and media 212 Tintin on postage stamps 216 Tintin coins 217 Books featuring Tintin 218 Tintin's Travel Diaries 218 Tintin television series 219 Hergé's Adventures of Tintin 219 The Adventures of Tintin 222 Tintin films
    [Show full text]
  • About the Contributors
    254 About the Contributors Dew Harrison is a Professor of Digital Media Art and works as the Associate Dean for Research and Postgraduate Study at the University of Wolverhampton, School of Art and Design, where she is also the Director of CADRE, Centre for Art, Design, Research, and Experimentation. She is a research- er and practitioner with a BA in Fine Art, an MA in Contemporary Art Theory, an MSc in Computer Science, and a PhD from the Planetary Collegium, CAiiA, in Interactive Art. Her practice undertakes a critical exploration of conceptual art, semantic media, and intuitive interfaces where she often works collaboratively and considers virtual curation a form of art practice. She continues to show her work internationally; most recently, two of her Digital Action Painting series were exhibited at the Centre for Contemporary Art in Poland, and has over 50 publications to date spanning digital art, consciousness studies, interactive games, art history, and museology. * * * Rina Arya is the Reader in Visual Communication at the University of Wolverhampton. Her research interests are interdisciplinary and include art theory and cultural studies. Her most recent monograph is Francis Bacon: Painting in a Godless World (Farnham, 2012). Forthcoming publications include Chila Kumari Burman: A Celebration of Shakti (KT Press) and Abjection and Representation (Palgrave Macmillan). Judith Aston was a pioneer in the emergent multimedia industry of the mid-1980s, working on projects with Apple Computing, the BBC Interactive Television Unit, and Virgin Publishing. Holding an MA in Social Science from the University of Cambridge, she went on to study for a PhD in Visual Anthropology and Computer-Related Design at the Royal College of Art, which she completed in 2003.
    [Show full text]
  • (DMT), Harmine, Harmaline and Tetrahydroharmine: Clinical and Forensic Impact
    pharmaceuticals Review Toxicokinetics and Toxicodynamics of Ayahuasca Alkaloids N,N-Dimethyltryptamine (DMT), Harmine, Harmaline and Tetrahydroharmine: Clinical and Forensic Impact Andreia Machado Brito-da-Costa 1 , Diana Dias-da-Silva 1,2,* , Nelson G. M. Gomes 1,3 , Ricardo Jorge Dinis-Oliveira 1,2,4,* and Áurea Madureira-Carvalho 1,3 1 Department of Sciences, IINFACTS-Institute of Research and Advanced Training in Health Sciences and Technologies, University Institute of Health Sciences (IUCS), CESPU, CRL, 4585-116 Gandra, Portugal; [email protected] (A.M.B.-d.-C.); ngomes@ff.up.pt (N.G.M.G.); [email protected] (Á.M.-C.) 2 UCIBIO-REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal 3 LAQV-REQUIMTE, Laboratory of Pharmacognosy, Department of Chemistry, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal 4 Department of Public Health and Forensic Sciences, and Medical Education, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal * Correspondence: [email protected] (D.D.-d.-S.); [email protected] (R.J.D.-O.); Tel.: +351-224-157-216 (R.J.D.-O.) Received: 21 September 2020; Accepted: 20 October 2020; Published: 23 October 2020 Abstract: Ayahuasca is a hallucinogenic botanical beverage originally used by indigenous Amazonian tribes in religious ceremonies and therapeutic practices. While ethnobotanical surveys still indicate its spiritual and medicinal uses, consumption of ayahuasca has been progressively related with a recreational purpose, particularly in Western societies. The ayahuasca aqueous concoction is typically prepared from the leaves of the N,N-dimethyltryptamine (DMT)-containing Psychotria viridis, and the stem and bark of Banisteriopsis caapi, the plant source of harmala alkaloids.
    [Show full text]
  • The Renaissance in Psychedelic Research: What Do Preclinical Models Have 2 to Offer
    CHAPTER The renaissance in psychedelic research: What do preclinical models have 2 to offer Kevin S. Murnane1 Department of Pharmaceutical Sciences, Mercer University College of Pharmacy, Mercer University Health Sciences Center, Atlanta, GA, United States 1Corresponding author: Tel.: +1-678-547-6290; Fax: +1-678-547-6423, e-mail address: [email protected] Abstract Human research with psychedelics is making groundbreaking discoveries. Psychedelics mod- ify enduring elements of personality and seemingly reduce anxiety, depression, and substance dependence in small but well-designed clinical studies. Psychedelics are advancing through pharmaceutical regulatory systems, and neuroimaging studies have related their extraordinary effects to select brain networks. This field is making significant basic science and translational discoveries, yet preclinical studies have lagged this renaissance in human psychedelic research. Preclinical studies have a lot to offer psychedelic research as they afford tight control of experimental parameters, subjects with documented drug histories, and the capacity to elucidate relevant signaling cascades as well as conduct invasive mechanistic studies of neurochemistry and neural circuits. Safety pharmacology, novel biomarkers, and pharmaco- kinetics can be assessed in disease state models to advance psychedelics toward clinical practice. This chapter documents the current status of psychedelic research, with the thematic argument that new preclinical studies would benefit this field. Keywords Psychedelic, Preclinical, Serotonin, Neuroimaging, Alcoholism, Anxiety, Depression, Substance dependence 1 INTRODUCTION The term psychedelic has come to be associated with a broad class of drugs with diverse chemical, pharmacological, and psychoactive effects. Alternative nomencla- tures have used hallucinogen, entheogen, psychotomimetic and other appellations to Progress in Brain Research, Volume 242, ISSN 0079-6123, https://doi.org/10.1016/bs.pbr.2018.08.003 25 © 2018 Elsevier B.V.
    [Show full text]
  • Multidisciplinary Association for Psychedelic Studies
    MULTIDISCIPLINARY ASSOCIATION FOR PSYCHEDELIC STUDIES VOLUME X NUMBER 3 PSYCHEDELICS & CREATIVITY 2 m a p s • v o l u m e X n u m b e r 3 • c r e a t i v i t y 2 0 0 0 Creativity 2000 MAPS (Multidisciplinary Association for 1 Introductions Psychedelic Studies) is a membership-based Rick Doblin, Ph.D., Jon Hanna and Sylvia Thyssen organization working to assist psychedelic 4 Psychedelics and the Creation of Virtual Reality researchers around the world design, obtain Excerpted from an interview with Mark Pesce governmental approval, fund, conduct and report on psychedelic research in humans. 6 Visionary Community at Burning Man Founded in 1986, MAPS is an IRS approved By Abrupt 501 (c)(3) non-profit corporation funded 9 The Creative Process and Entheogens by tax-deductible donations. MAPS has Adapted from The Mission of Art previously funded basic scientific research By Alex Grey into the safety of MDMA (3,4-methylene- 12 Left Hand, Wide Eye dioxymethamphetamine, Ecstasy) and has By Connor Freff Cochran opened a Drug Master File for MDMA at the U.S. Food and Drug Administration. MAPS is 17 Huxley on Drugs and Creativity Excerpted from a 1960 interview for The Paris Review now focused primarily on assisting scientists to conduct human studies to generate 18 Ayahuasca and Creativity essential information about the risks and By Benny Shanon, Ph.D. psychotherapeutic benefits of MDMA, other 20 MAPS Members Share Their Experiences psychedelics, and marijuana, with the goal Anecdotes by Abram Hoffer, M.D., Ph.D., FRCP(C), of eventually gaining government Dean Chamberlain, Dan Merkur, Ph.D., Sam Patterson, approval for their medical uses.
    [Show full text]
  • LSD – Sorgenkind Und Wunderdroge Presseecho Zum LSD-Symposium in Basel Mit Zeittafel Zur Geschichte Des LSD
    LSD – Sorgenkind und Wunderdroge Presseecho zum LSD-Symposium in Basel mit Zeittafel zur Geschichte des LSD Redaktion Webteam www.eve-rave.net Berlin Pressemitteilung vom 27. Februar 2006 zum LSD-Symposium in Basel Auf einem Symposium zum 100. Geburtstag von Albert Hofmann, bei dem der Entdecker der Sub- stanz mehrfach auf dem Podium bereitwillig und mit viel Humor Fragen beantwortete, suchte man den zukünftigen Platz von LSD in der Gesellschaft. Etwa 80 Referenten aus aller Welt diskutierten in Basel mit einem gutend Dutzend ausstellenden Malern und auftretenden Musikern, 200 Journa- listen und etwa 2.000 Besuchern drei Tage im Kongreßzentrum der Messe Basel die zentrale Frage: Welchen Platz kann und soll LSD in einer Gesellschaft einnehmen? Der Titel der Veranstaltung »Sorgenkind und Wunderdroge« konnte kaum besser gewählt sein. Noch heute, fast sechs Jahrzehnte nach der Synthese durch den Chemiker Albert Hofmann im Jahre 1938, steht die Substanz in einem zutieft ambivalenten Ruf. In allen Ländern der Erde ist sie verboten, auf der anderen Seite gibt es genauso lange währende Bemühungen, das potente Psyche- delikum als Medikament oder sakralen Bewußtseinsfahrstuhl einsetzen zu dürfen. Diese Pressmitteilung ist eine Art Presseecho zum LSD-Symposium und ist im Wesentlichen aus Zitaten, die aus den am besten recherchierten respektive treffendsten Zeitungsartikeln, die zum respektive nach dem Symposium erschienen sind, zusammengestellt. Anfangs sind zahlreiche Zitate von Albert Hofmann wiedergegeben, dann folgen Informationen zu Medizin, Therapie, Kultur, Politik u.a.m. und zum Schluß eine Zeittafel zur Geschichte des LSD. HTML-Version http://www.eve-rave.net/abfahrer/presse/presse06-02-27.html Das detaillierte Programm des Symposiums ist unter www.lsd.info zu finden.
    [Show full text]