Anti-DACH2 (Aa 169-181) Polyclonal Antibody (DPABH-17849) This Product Is for Research Use Only and Is Not Intended for Diagnostic Use

Anti-DACH2 (aa 169-181) polyclonal antibody (DPABH-17849) This product is for research use only and is not intended for diagnostic use.

PRODUCT INFORMATION

Antigen Description Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator for SIX1 and SIX6. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Is recruited with SIX6 to the p27Kip1 promoter in embryonal retina. SIX6 corepression seems also to involve NCOR1, TBL1, HDAC1 and HDAC3. May be involved together with PAX3, SIX1, and EYA2 in regulation of myogenesis. In the developing somite, expression of DACH2 and PAX3 is regulated by the overlying ectoderm, and DACH2 and PAX3 positively regulate each others expression (By similarity). Probably binds to DNA via its DACHbox-N domain.

Immunogen Synthetic peptide: TRKQAVNSSRPGR by a Cysteine residue linker, corresponding to internal sequence amino acids 169-181 of Human DACH2

Isotype IgG

Source/Host Goat

Species Reactivity Mouse, Human

Purification Immunogen affinity purified

Conjugate Unconjugated

Applications WB, ELISA

Format Liquid

Size 200 μl

Buffer Constituents: 0.5% BSA, Tris saline, pH 7.3

Preservative 0.02% Sodium Azide

Storage Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.

GENE INFORMATION

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]

Official Symbol DACH2

Synonyms DACH2; dachshund homolog 2 (Drosophila); dachshund homolog 2; FLJ31391; MGC138545;

Entrez Gene ID 117154

Protein Refseq NP_001132986

UniProt ID A8K3I1

Chromosome Location Xq21.3

Function DNA binding; nucleotide binding;

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]