one goal

2008 annual report The organization of choice for those who are serious, passionate and committed to finding a cure for diabetes.

a cure About the Diabetes Research Major Contributors 9 Institute Foundation 1 The Heritage Society 14 Message from the Chairman and President 2 Boards of Directors 15

Making Progress Possible: DRI Foundation Staff 17 Research Review 4

Financials 6 Diabetes Research Institute Foundation MISSION: To provide the Diabetes Research Institute with the funding necessary to cure diabetes now .

The Diabetes Research Institute Foundation was founded in 1971 by a small group of parents of children with diabetes who were committed to finding a cure for this devastating disease. Driven by hope and fueled by the need to end their children’s suffering, they banded together to support a promising research program at the University of Miami solely aimed at curing those living with diabetes. This singular goal remains today.

The Foundation has evolved into an international The leadership of the Foundation has also been coalition of business leaders, celebrities, research instrumental in voicing the plight of those with scientists, clinicians, families and other concerned diabetes in the public arena. individuals who have elevated the importance of cure-focused research and shifted the direction of Together with other leading diabetes advocacy funding into this critical area. organizations,the DRI Foundation has appeared before Congress to request increased funding for diabetes The DRI has become the world leader it is today research, and has made recommendations on the through the dedication and perseverance of the future direction of research appropriations. people involved with the Foundation – those who have a personal stake in the eradication of this disease. On an annual basis, the Foundation hosts numerous Supported by private philanthropy, the DRI Foundation informational workshops for people with diabetes has been and continues to be the organization of choice and their families focusing on the latest advances for those who are serious, passionate and committed toward a cure. Additionally, Institute and Foundation to finding a cure for their loved ones and millions of faculty and staff participate in a variety of print and others with diabetes. broadcast public service programs locally, nationally and internationally, which are designed to educate Over the years, thousands of generous individuals and the community on current research progress and companies have given of their time and resources to help the newest diabetes management techniques. fulfill the DRI’s mission. One of the Foundation’s most faithful partners is the Building and Construction Trades A 501(c)(3) not-for-profit corporation, the Foundation Department (BCTD) of the AFL-CIO, whose members have raises funds through individual and corporate donations, raised millions of dollars to construct and equip the DRI memberships, foundation grants, special events, and facility, dedicated in 1994, and who continue to fund its planned giving, which allows donors to leave a personal vast research initiatives. legacy by providing a gift in the form of a will, trust or other deferred giving vehicle. Through a special program called the Blueprint for Cure, which dates back to 1984, the American labor The DRI Foundation has thousands of members both movement pledged its unwavering support of the in the United States and around the world, and has DRI’s mission to cure this disease. Building upon successfully expanded into various locations, including their decades-long commitment, the BCTD has the opening of regional development offices in New York, strengthened their ongoing partnership with the Long Island and Washington, D.C. DRI through a new effort called Project Type Zero: The hope for a diabetes-free tomorrow. Thanks to the efforts of thousands of building and construction trade members, millions of dollars have been raised for the Institute 's cure-focused research.

2008 annual report 1 Message from the Chairman and President Responding to a parent’s question about the focus of the Diabetes Research Institute and Foundation, a long-time board member pointedly stated: “We want to turn off the lights.” In other words, we aim to put ourselves out of business by fulfilling our mission to discover a cure for diabetes.

You would undoubtedly hear a similar response from any other board member, scientist, clinician or Foundation professional, as this has been our singular goal since the inception of the organization more than three decades ago.

Every year, we strive to make that goal a reality. with which we all work. To ensure that no time or In 2008, we took a giant step toward this end by resources are wasted, the mission of the Diabetes funding promising scientific initiatives and commencing Research Institute Foundation is: an ambitious plan to accelerate the discovery of a cure. It was also a year in which we culminated our five-year To provide the Diabetes Research Institute with strategic plan to raise $100 million for the Diabetes the funding necessary to cure diabetes now . Research Institute. We are extremely proud to report that we have not only achieved our goal, but have Recognizing that the scientific possibilities have never surpassed it by 25 percent, raising more than $125 been greater, we are elevating our fundraising objectives million over the last five years. well beyond previous levels to provide our scientists with the resources necessary to implement a broad, new We raised this level of funding while maintaining strategy that holds great promise for a cure. Under the sound fiscal management and strict accountability leadership of Scientific Director Dr. Camillo Ricordi, the of our donations. For the second consecutive year, the DRI has developed a new roadmap in cure-focused DRI Foundation has earned a four-star rating, the highest research that enhances traditional cell-based therapies, possible, from Charity Navigator, the nation’s largest merges many previously unrelated biomedical independent evaluator of charities. Only 15 percent of disciplines, and utilizes diverse medical and technical all charities evaluated have received back-to-back four- expertise that is critical for success in this new era star ratings, indicating that, “the Diabetes Research of medicine. To fund this novel approach, the DRI Institute Foundation outperforms most charities in Foundation has adopted a new strategic plan to raise America in its efforts to operate in the most fiscally $150 million over the next five years. No doubt, we are responsible way possible.” embarking upon this campaign during the most difficult fundraising environment in decades. Despite these Thanks to the unwavering generosity of our donors, economic challenges, however, we will not compromise the DRI Foundation now ranks among the leading our standards. We have maintained the high-quality, diabetes fundraising organizations in this country and world-class research program for which the DRI has internationally. Yet with a sole focus on curing those become known. We are confident that we can achieve living with this disease, we remain unique in the world our goals with your continued generosity and the of diabetes. It is one of the major reasons why we ongoing support of all of our donors. continue to attract those who are serious, passionate and committed to this very same goal. The DRI’s research roadmap has been laid out in our new Case Statement, Leading the World to a Cure, This past year, when the board of directors convened which conveys the many ways in which the DRI is to develop a new five-year plan, there was universal Leading with Excellence, Leading with Passionate agreement that we need to hasten our efforts unlike Commitment and Leading with Vision – and why those ever before. Recognizing that tomorrow isn’t soon who have a personal stake in eradicating this disease enough to cure the millions of children and adults should support this organization. If you would like to living with diabetes, we adopted a bold, new mission obtain a copy of our Case Statement materials and video, statement which conveys the true sense of urgency please contact the Foundation office at 1-800-321-3437.

2 DIABETES RESEARCH INSTITUTE FOUNDATION Thomas D. Stern Robert A. Pearlman Chairman President and Chief Executive Officer

The Foundation is largely defined by passionate commitment Diabetes 2.0 Conference, held in New York City last October. and it is palpable in the efforts put forth by so many We were joined that day by a cadre of experts, from DRI dedicated individuals. Much of our growth has resulted scientists and leading psychologists to online specialists and from the involvement of dedicated volunteers, who serve diabetes bloggers, who shared their knowledge and helped on event committees, raise funds on our behalf in their own everyone connect with each other. For those who could not communities across the country and participate in outreach attend this special day, videos of the presentations were programs, like the PEP Squad. made available on our web site. Going forward, we will be increasing our online efforts, not only with additional web- After introducing this family outreach group in 2007, we based video presentations, but through a number of new expanded our PEP Squad (Parents Empowering Parents) initiatives we will be introducing in the coming year. beyond Florida to both our Long Island and Northeast regions. The PEP Squad continues to attract new leaders This is a very exciting time for the Diabetes Research Institute while offering support, lending an ear and sharing and Foundation! We hope we can count on your continued advice with other parents who have a child with diabetes. support and involvement so that we can all realize our dream Facilitated by licensed social workers and psychologists who of a cure. Thank you again for your friendship, loyalty and the are experienced in the area of diabetes, the PEP Squad fields valued trust that you have shown through your benevolence. calls and emails from parents across the U.S. and as far away as Greece and the Netherlands, to name just a few places. Sincerely,

This past year, we bolstered our activities by appointing new lay leaders to our regional boards of directors and committees. These dedicated individuals bring their unique talents to the DRI Foundation, help us expand our base of support and introduce new people to the organization Thomas D. Stern, Robert A. Pearlman, through our many events. One event in particular that was Chairman President and Chief highly attended and received broad recognition was our Executive Officer

2008 annual report 3 Making Progress Possible: Research Review

From providing the seed funding for become – or differentiate into – insulin-producing cells. At each stage, a “developmental switch” needs to be jumpstarting new research ideas to turned on to drive the cell down the intended path. ensuring the continuation of promising The key is to be able to insert these developmental research projects, the Diabetes Research switches, or signals, safely into the cell. Using the protein transduction technology described above, DRI scientists Institute Foundation plays a major have successfully tested four of these signals for their role in supporting the Institute’s ability to induce pancreatic cell differentiation and a multidisciplinary program. Below is fifth is currently undergoing preliminary studies. In addition to using embryonic stem cells, the research a summary of the progress made last team has expanded the study to include other cell types, year by DRI scientists in such cutting- such as cord blood and amniotic fluid. edge areas as stem cell research, tissue In a related project, researchers are testing the ability engineering, nanotechnology and to turn cells from other organs into insulin-producing other cell-based therapies that are cells, a process known as transdifferentiation. Previous made possible through the generous research studies have identified a combination of three genes that, when delivered to the exocrine (non insulin- donations to the Foundation. producing) tissue of the pancreas using viruses, turned these cells into insulin-producing cells. The DRI team is testing this approach by inserting the three critical Reprogramming a Person’s Own Cells proteins using the safer alternative of protein transduction technology. Experiments are already The DRI’s stem cell team has developed a new approach underway to test their ability to alter cell function to reprogram adult stem cells by “turning back the both in vitro and in small animal models. clock.” Building upon research that demonstrated that a person’s own skin cells can be returned to an undifferentiated state, similar to that of an embryonic Development of “Suicide Genes” to Enable Safe stem cell, the DRI is testing the same concept but using Use of Stem Cells a much safer approach. The reprogramming of the skin cells resulted when four master genes were inserted While embryonic stem (ES) cells hold great promise using retroviruses, which have numerous safety for curing diabetes and other diseases, their use poses concerns. DRI researchers are using protein transduction certain risks to patients. By their very nature, embryonic technology, which offers most of the advantages with stem cells continue to divide and multiply, and if left none of the drawbacks. The stem cell team has already unchecked, can form tumors called teratomas. Unless used protein transduction technology to differentiate safety mechanisms are put in place to prevent the early stem cells into mature cell types. This is the first occurrence of tumors, human embryonic stem cell attempt to apply the same principle to the opposite goal approaches will not be clinically applicable. DRI – reprogram adult cells into stem cells. Armed with this researchers are working to genetically modify ES cells preliminary data, the researchers have been awarded a with specific “suicide genes” that will be selectively grant from the National Institutes of Health to fully activated in 1) cells that differentiate into tissues other explore the potential of this technology. than pancreatic insulin-producing cells; and 2) cells that continue to divide after differentiation. This double fail- safe mechanism is designed to ensure maximum safety Scientists Identify Key Steps for Beta for the clinical use of these cells. The DRI is currently in Cell Development the process of establishing a collaboration with the prestigious Roslin Institute in Scotland to deliver these Scientists have determined that embryonic stem cells genes using a technology called “gene targeting.” proceed through five developmental stages in order to

4 DIABETES RESEARCH INSTITUTE FOUNDATION Novel Agents Aimed at Replacing Harsh Drugs several factors that enhance the supply of oxygen to the encased islets; emitting nano-sized drugs that The DRI’s drug discovery team has been focusing on will reduce inflammation at the transplant site; and identifying and developing new small molecules to containing “helper cells” that enhance islet survival prevent the rejection of transplanted insulin-producing and function. cells as well as thwart the autoimmune attack that initially destroyed these cells in the patient’s pancreas. Key Signals Direct Beta Cell Growth It is well known that these immune responses cannot occur without a cell-to-cell signaling called costimulatory The DRI's Molecular Biology team recently identified interaction. In particular, researchers have been taking an important “master regulator” found in pancreatic a close look at the CD40-CD154 pathway, which has islets. These tiny genes create signals called microRNAs shown to be important for promoting successful islet (miRNA) that regulate key biological functions, such as transplantation. Effectively blocking this pathway cell proliferation (growth) and the transformation of would induce transplantation tolerance and prevent the stem cells into adult cells. The team discovered that a recurrence of autoimmunity. Although it was thought group of these signals, miR-7, appeared in the islets in that small molecules would not block this interaction, it disproportionately higher numbers – 200-fold greater has become clear that they can. The DRI’s drug discovery in pancreatic islets as compared to the non-islet tissue team has now obtained proof-of-principle evidence of the organ. The researchers believe that miR-7 has that small molecules can effectively inhibit the critical a very early, crucial role in the development of islet CD40-CD154 interaction, which might provide new cells as well as in maintaining their insulin-producing clinical therapies in many areas. function. They are testing approaches to see if modifying the amount of miR-7 could represent a novel way to generate insulin-producing cells. The team is currently Scientists Combine Nanotechnology and performing studies to define the role of miR-7 in the Engineering Techniques to Protect Islets developing mouse pancreas. These studies will help identify how genes regulate islet development and The DRI’s tissue engineering team is working on a provide tools for new treatment strategies to number of new approaches to protect transplanted cure diabetes. cells from the recipient’s strong immunological and inflammatory responses while providing the critical nutrients needed to sustain healthy function. The primary focus is on the use of alternative transplantation sites and new biomaterials to house these cells. Initial studies have demonstrated that long-term restoration of blood sugar control can be reproducibly achieved after transplantation of islets into a prevascularized (filled with blood vessels) device in an experimental model. By combining nanotechnology and advanced engineering principles, the team is now working to make a number of improvements to the device, including: improving its physical structure; developing a “bioactive scaffold” that will house the islets and prevent them from clumping together; delivering anti-rejection drugs within the device instead of throughout the entire body; adding

2008 annual report 5 Financials

Diabetes Research Institute Foundation Statement of Activities for the Year Ended

June-08 June-07 Support and Revenue

Contributions $8,856,252 $29,014,511 Reimbursement Contracts $1,612,193 $597,742 Special Events, net of expenses $5,735,803 $4,567,015 Investment Income $(137,150) $1,820,794

$16,067,098 $36,000,062 Expenses and Fund Balances

Program Services

Research provided to the Diabetes Research Institute $14,666,713 $15,287,108 Community Education $646,236 $599,087

$15,312,949 $15,886,195

Support Services

Administration and General $1,429,783 $1,074,820 Fundraising $2,083,604 $2,120,162

$3,513,387 $3,194,982

Change in Net Assets $(2,759,238) $16,918,885

Net Assets, Begining of Year $43,840,758 $26,921,873

Net Assets, End of Year $41,081,520 $43,840,758

Fundraising Percentage Fundraising Expenses as a Percentage of Support and Revenue 13% 6%

6 DIABETES RESEARCH INSTITUTE FOUNDATION 2008 annual report 7 To our donors with sincere gratitude…

The Diabetes Research Institute Foundation wishes to gratefully acknowledge all of our donors, whose generosity helps keep hope alive for the millions of children and adults who suffer with diabetes. Your ongoing support allows DRI scientists to continue their pursuit of a cure through so many promising scientific initiatives.

Every year, many new donors join the DRI family. While every gift, no matter the size, helps move us closer to a cure for this disease, we would like to take this opportunity to acknowledge our major contributors, whose unwavering dedication and unparalleled generosity has truly helped make progress possible. The individuals, corporations and foundations listed below have given selflessly throughout the history of this organization. Their names appear in the corresponding giving levels.

Again, we extend our sincere gratitude to all of our donors for their continued support of the Diabetes Research Institute and Foundation.

8 DIABETES RESEARCH INSTITUTE FOUNDATION Major Contributors

Visionaries - $10,000,000+ Peacock Foundation, Inc. Florida Power & Light Employees Ricardo Puente Future Leadership Foundation, Inc. Building and Construction William and Deborah Rand Jeanine Forman-Ham Trades/AFL-CIO Sheet Metal Workers Florence Frank J. Enloe and Eugenia J. Dodson* International Association Paula N. Freund* Raymond and Russell Johnson* Stacy Joy Goodman Memorial Phyllis and Richard L.* Gelb and Family Sylvia and Rowland Schaefer Foundation Dr. and Mrs. Phillip T. George Dr. Denise R. and Thomas D. Stern and Family United Association of Journeymen & Linda and Barry Gibb Chairmans Council - $5,000,000+ Apprentices of the Plumbing & Pipe Mary and Jay N. Goldberg Fitting, Sprinkler Fitting Martin Granowitz Polly and Baron de Hirsch Meyer* Industry of the U.S. & Canada Jill and Allen Greenwald Leon J. Simkins United Brotherhood of Carpenters Harley Davidson of Miami, L.C. & Joiners of America Fran and Mel Harris United Union of Roofers,Waterproofers The Holtz Family Leadership Council - $1,000,000+ and Allied Workers IBM Employees Jill and Cliff Viner Isolde Kaskel* Michele Bowman and Louis Kaczmarek Joseph Underwood The Martin Kleiman Family Trudy and Paul Cejas Governors’ Society - $500,000 + Isabel and Sam* May Diabetes Foundation of Florida Marge Kleiman Mintz Mary and Randy Dorfman Jeanne and Virgil Christopher* Gary Kleiman and Chris McAliley The Esformes Family, Annie Rose Cohen* Glenn Kleiman and Gise Turner and Nate Esformes Tom Curtis Connie and Harvey Krueger Foundation for Diabetes Research E.R.A.S.E. Diabetes Tova Leidesdorf Inserra Family Foundation Joan and William J. Fishlinger Lions Club International International Association of Bridge, Florida Jaycees Eleanor Lowe Structural and Ornamental and Susan and Douglas D. Gallagher Charlotte and Eugene Milgram Reinforcing Iron Workers Paola and Piero Ludovico Gandini The Mostyn Foundation International Association of Louise K. and Robert T. Held, Sr.* Penny and Robert A. Pearlman Heat & Frost Insulators and Lola and Donald Jacobson Cristina and Ramon Poo Asbestos Workers Blanche E. Kroloff* Richard H. Simons Charitable Trust International Brotherhood of Amy and Alan Meltzer The Seaver Institute Boilermakers, Iron Ship Builders, Million Dollar Hole in One Miriam and James J. Sensale Blacksmiths, Forgers & Helpers On Target/Committee of 500 Muriel and Sherman Simon International Brotherhood of Risa and Jeff Pulver Philanthropic Fund Electrical Workers Red Apple Group Shapiro-Silverberg Foundation International Brotherhood of Teamsters Redfern Foundation Edith and Martin B. Stein International Union of Bricklayers Valerie and Camillo Ricordi Burton S. and Barbara F. Stern & Allied Craftworkers The Family of Samantha Max Stern Symonds Family International Union of Elevator Ferne and Daniel Toccin Ethel J. Vilm* Constructors ULLICO Management Company Roberta and Bruce Waller International Union of Operating Washington CLUB Engineers Rita and Stan Weinstein International Union of Painters Distinguished Humanitarians - Westreich Foundation and Allied Trades $250,000 + Sally Zak* The Jack Parker Corporation Sonja Zuckerman Carole and Barry Kaye Bally’s/Paris and Flamingo Las Vegas Richard H. Kline* Jane and Bill Burt Eleanor C. and Joseph* Kosow Ivette and Juan Calles Grand Founders - $100,000+ Laborers’ International Union of Pearl Coulter* North America Diabetes Research Institute Lisette and Norman* Ackerberg Alfred P. LaRose* Ambassadors Barbara and Philip Altheim Operative Plasterers’ & Cement Masons’ Diabetes Research & Wellness American Building Maintenance Co. International Association of the Foundation Arison Family U.S. & Canada Kelly and Harold Doran Aurora Foods, Inc.

2008 annual report 9 Bankers Life & Casualty Co. Henry A. Keller, Jr. Sandy and Paul Steinberg Autis H. Barker Joan Keller Marilyn and Gary Studley The Bastin Family Sue and Norman Kenyon Suburban League Alan Bauer* Barbara and Martin P. Klein Anna and Leonard Thun Diane and Bernard Beber Priscilla & Ira Kleinberg Foundation Tiffany & Co. Margaret and Raymond Berner Sylvia Kwasha Lois and Joseph Umbach Buddy Blair* Lucrezia and Vito LaForgia Van Pelt Foundation Nancy and Jerry Blair Oscar and Vivian Simkins Lasko Walgreens Martha and Tom Blash* Pat and Mac Levitt Barton G. Weiss The Family of Dr. Adam H. Bloom Sandra and Sidney Levy Dorothy and Jack Weiss Boehringer Mannheim Corp. Lloyd and Helen Dilworth Foundation James Wenck, Jr.* Delores S. and William K. Brehm Robert Mace Lois and Richard Werner Sylvia Bruce* Anna Machado Helene Westreich Marty B. Bruder Marion A Roletti Foundation Cynthia and Philip Wolman Valetta Arlene Byrn* Beverly and Mel Marks Ann Zorn* Henry E. Caballero Matthew Miller Family Barbara and Martin E. Zweig Kate Callahan and Peter Benjamin Maurice Greenberg/Starr Foundation Carnival Cruise Lines Micki and Joseph Mele Cure Diabetes Now Miami Beach Chapter/NCCH Founders - $50,000 + Cynthia D. Carr Miccosukee Tribe of Indians of Florida The Charles Evans Foundation Michael J. and Katherine E. Dr. and Mrs. Vincent J. Abbatiello Cushman & Wakefield, Inc. Franco Foundation Abbott Diabetes Care Cohen Family Charitable Foundation Dottie and Julie Miller Adco Electrical Corporation for Jake Cohen Mutual of America Kareeman and Tarek Al-Fassi Brian and Cheryl Coughlin Novo Nordisk Pharmaceuticals Carl J. Althoff* Tom Daly Olstein Family Foundation for Ambassador Construction Co., Inc. Dotty and George* D’Amato Brooke Goldfarb American Airlines Reva Dauer* Onesource Facility Services, Inc. American Manhassett Lucille S. Dell* Jane Parker and Francis Cosentino Barbara Annis The DeMatteis Family Foundation Feli and Gerd Petrik Lillian Baker* Jodi and Bob Dickinson Carolyn Pflugk in Memory of Peter Pflugk The Bakery, Confectionary, Tobacco Robert E. Dooley Steven Posner and Kathryn Chesler Workers and Grain Millers The Durst Organization Judith A. and Paul B. Reisman International Union Cindi and Paul Elias The Retirement Research Foundation Victor Ballard* Cindy Epstein Margaret H. Reynolds* Marlene and David Berg Raymond Falkenstein* Jed Ringel Biogen, Inc. Elizabeth and Max Feldberg Fund Sondra Rose Blank Family Foundation, Inc. Fidelity National Title The Rose and Burton Kahn Belle and Albert Blanton Insurance Company Family Foundation Esther Blattner* Randy and Mark Fisher Ruth and Albert* Rosenberg Carol Nudelman Blumberg and Derry and Steven Fishman Charles Royal Morton Blumberg Frank Strick Foundation Madelyn Rubin Boca Group International, Inc. Fraternal Order of Eagles Mark R. Rubin The Linda and Douglas Boyd Family Marvin Ross Friedman Charles Sakele* C. Allen Brice Gibb Family Foundation Leslie and Ricardo Salmon Philip Brice Nancy and Lawrence E. Glick Sandoz Research Institute Rita and Samuel* Brodie Jane and Jerrold F. Goodman Ruth and Samuel Schwartz BrookBridge Consulting Services, Inc. Esther and Marc S. Goodman Inge and Maurice Schweizer* Bvlgari Alvin Grabow* Barbara F. Scott Camp NYDA Junior Division, Inc. Linda and Glenn Greenberg Jacci S. and Floyd E. Seskin Mary and Stephen Carner Elizabeth A. Guon Hazel and Marvin Shanken Carrousel Elizabeth and Gary Hall, Jr. Shell Key West Challenge CB Richard Ellis Glen Cove Police Benevolent Association Holly and David Sherr Mitzi and Sol Center Shirley D. Harris S L Green Management LLC C.H. Robinson Company Worldwide, Inc. The Hatz Family Sherrie Garfield in Memory of Chase Manhattan Bank Kirsten and Steven Heinemann Joseph Garfield* Roberta and Harvey Chaplin John W. Henry Susan Winberg and Kenneth Shewer Tracy and James Ciocia Barbara Herzberg The Morton F. Silver Family Citigroup Sam Herzberg Freda F. Silvers* Carole and H. L. Clark Judith and Lawrence Howard Kathy Simkins Collins Building Services, Inc. Dr. Jack Widrich Foundation Barbara and Sheldon Singer Dr. Stephen B. Colvin* and JAD Corp. of America Louise B. Soehner Mrs. Helane Brachfeld-Colvin Lynne and C. Shelton James Jana and Steven Sonberg ConEdison Solutions, Inc. Jeffrey Modell Foundation South Florida District Optimists Murray Cornblum Paul Tudor Jones International Corporate Interiors Contracting, Inc. Joseph Alexander Foundation , Inc. Spear, Leeds & Kellogg Coscan Waterways The Max and Yetta Karasik Sportsmen for Charity Brian and Cheryl Coughlin Family Foundation Gerald J. Steinberg* In Memory of Pat Covelli

10 DIABETES RESEARCH INSTITUTE FOUNDATION Arlyn and Stephen Cypen Mollie Kalman* Richard Schoninger and Damon Biotech Reuben Kaplan* The Schoninger Fund Gertrude Davenport* Amy and Aaron Katz Bruce and Mary Jo Schumin Kathleen and Charles Delle Donne Eleanor and Herbert* Katz Donna and Marvin Schwartz Delta Air Lines Helene* and Stanley Kellert The Segel Company, Inc. Gail and Charles DelVecchio Kelly Press, Inc. Mildred and Julius Ser Gillian and Elliot* Dinnerstein Patricia and James Kennedy Tom Shanks Charles Domina Kenneth A. Lattman Foundation, Inc. Samantha Shanken and Michael Baker Gary Dubin Tammy and Steven Klein Sherwood Medical Industries Maxine Dubin Stanley M. Kossoff Iris and Milton Shlansky Betty and Lowell Dunn Burt Kozloff Natasha and Thomas Silver Eli Lilly & Co Janie and Ron Kupferman The Sidney, Milton & Fashion Accessories Benefit Ball Nancy and Richard Ladd Leoma Simon Foundation F.J. Sciame Construction Co., Inc. Ladyzinski Family Foundation Rose Sipocz* Chris and Kevin Fee Maximilian Lavine* Jay Skyler and Mercedes Bach The Milton and Sally Feldman Barbi and Warren Lazarow Sandra Smith Foundation Lehman Brothers Alan Smurfit Doris Felner Fran and Robert Leichtung Claudine Smurfit Claudia M. Ferero Ann and James Long Iolanda M. Sobol Firequench, Inc. Long Island Board of Realtors Donald Soffer First Quality Maintenance LTD. M. Robert Goldman & Company Inc. Frosene Sonderling* Mary Beth and Bruce Fishbein Joan and Martin Maddaloni Southern Wine & Spirits of South Florida Valerie and Marc Fishman Magnus and Petherick Family Abbe and Eric Spar Shirley Fletcher Mainco Elevator & Electrical Corp. Marilla M. Spear Fluor Constructors International, Inc. Marie G. Morandi Joan Spector Kathi and Scott Forbes Medimmune Stanford Financial Group The Foundation for Transplant Research Milrose Consultants, Inc. Debbie and Lou Steiner Patricia Frankel MOSAIC Structure Tone Inc. Edith and Sol Freedman Ted Moudis Associates, Inc. Thomas J Lipton, Inc. Christine M. Frick* Mystic Pointe To The Point Joel S. Friedman and Victoria Agron Sheila and William Natbony Together Against Diabetes Milton I. Friedman* NMAPC, Inc. The Torch Foundation Joan Galison Neiman Marcus Transel Elevator and Electric, Inc. John Gallin & Son, Inc. Neocrin Company Triangle Services, Inc. Gina and Peter Gardner New York City Transit Authority Turner Construction Company Gladys and Martin Gelb Judy and J. P. Newell, III Unity Electric Co., Inc. The Genatt Family Newmark & Company Real Estate, Inc. U.S. Trust Bank of America Genovese Drug Stores/Eckerd Kathryn A. Nicolosi Private Wealth Management Corporation The Nieweg Foundation Vanguard Construction & Niety and Gary Gerson Brenda Novak Development Co., Inc. Herbert and Elaine Gimelstob The Oringer Family Foundation Vivotech Becky and Braxton Glasgow Lisa and James Pappas Judy and Bruce Waldman Gloria and Stanley Goldman Fred and Mabel R. Parks Foundation The Reverend Ann Walling Moises T. Grayson Louise and Allan Pashcow Laura Weinsoff Amy, Scott, Jonathan & Lexi Greenwald Perlmart Anne Weinstock* Grossjung Foundation The Picard Family Laurie and Lawrence Wells Grubb & Ellis Platinum Maintenance Service Corp. Leslie Westreich Guardian Service Industries, Inc. Louise and Faustino Poo Rhoda and Donald White Edgar and Frieda Hamm Trust Porsche Dan Whitney a.k.a. Larry the Cable Guy Kenneth Harple Ethel C. Posnick The Paula and Tom Wilson Family Harvard Maintenance, Inc. The Puntillo Family Josephine Wolf* Sigrid Haukland* Quality Building Services Corp. Wollowick Family Foundation Health Foundation of South Florida Quality Fire Protection Consultants, Inc. Zwicker Electric Co., Inc. Hector Family Foundation Maria and Eric Reeps Lady Monica Heftler Gertrude Reis* Heisman Trophy Trust Remco Maintenance Corporation Benefactors - $25,000+ H. Kurtz Henley* Helen L. Rossi* Gertrude Hirsch Marie and Charles Rizzo Abbey Foundation The Homan Foundation Blanca I. Rodriguez Jayne and Leonard Abess/City Iacocca Foundation Iris and Gene Rothstein National Bank of Florida IBM Foundation Gloria and Dr. Larry Ruchman ACC Construction Corporation IESI Corporation Florence and Arnold* Rubin Alice and Arthur Adams* Insulin-Free World Foundation Olga and Carlos Saladrigas Sari and Michael Addicott JDP Mechanical, Inc. Roberta Sands Adelhardt Construction Corporation Jack & Pauline Freeman Foundation Irela and Jose Saumat Arthur and Shelley Adler Jack Taylor Family Foundation ScheinMedia Annette and Lee Aerenson The Jeffrey A. Altman Foundation Schindler Elevator Corporation A.F. Best Securities, Inc. and Owl Creek Asset Management

2008 annual report 11 AFL-CIO Housing Investment Trust/ Cornblum Family Norma and Herbert* Hackmeyer AFL-CIO Building Investment Trust Cure Diabetes Now Daniel J. Hannon Ahmuty, Demers & McManus David A. Beckerman Foundation Hanover Moving & Storage Co., Inc. AIG Jane and Lawrence David Deana and Stephen Hanson Michael C. Alexander Dawn Mintz Memorial Fund Nicki and J. Ira Harris Allergan Medical Optics Day and Zimmerman Dr. Robin Nemery and Barry Hauser Amalgamated Transit Union DeLancey Printing The Headlands Foundation American Fruit & Produce Corp. Merle M. DeLancey Health Net, Inc. American Healthcorp., Inc. Delicious Brands, Inc. Ellen and Barry Heimlich American Home Products Corp. Ann and Norman Didriksen Mr. and Mrs. Robert T. Held, Jr. American International Group Distillery Wine and Allied Workers Roberta and Lawrence Helfant A-One-A Produce & Dairy Donaldson Acoustics Co., Inc. Mary K. Heller Aragon, LLC Amy and William Donner Marilyn and Carl Hellman Helen M. Aren* Debbie and John Drury H. Herbert Myers Memorial Armando Alejandre Jr. Dudley Foundation Foundation Memorial Foundation Durnan Group, Inc. Janet and Barrett Hess A/R Environetics Group, Inc. ESS & VEE Acoustical Contractors, Inc. Madeline and Herbert Hillsberg ATCO Properties & Management, Inc. Mildred Edelstein Louis Hirschfield Sallie* and David Balogh Lola and Gus Efthimiou The Hirshleifers Lydia and Paul Balzano Eleanor & Roy Nester Family Foundation HLW International LLP George W. Bauer Family Foundation Sheila Elias Hochberg Family Foundation Bay Area Produce Susan and Gerard Elicks Lee S. Hochwald* Bear, Stearns & Co., Inc Gail E. Ellis and Sandy J. Fox Home Savings Bank of Florida Beatrice & Samuel A. Seaver Foundation Erectra Construction Corp. Hotel Employees and Restaurant Marie Belanger Eurohypo AG Employees International Union Suzanne and Marc Bell Rosa and Francis Feeney Household Credit Card Services Arvilla and Leo* Berger Mr. and Mrs. Keith Fell Edith and Robert Hudson Ruth and Philip Berman Marilyn Fellman Peter Huri Betagene Incorporated Fine Art and Craft Co., Ltd. ICAP Services North America LLC Suzanne and Donald Bezahler Pamela and Barry Fingerhut Insignia/ESG, Inc. Jennifer and Robert C. Bills Lillian Fiolic* International Association of Fire Fighters Biscayne Greyhound Track Fisher Brothers Management Co. Intracoastal Abstract Co., Inc. Blavin & Company FIT USA Foundation Myra and Allen Jacobson The Mary Farrell and Stuart Florida Association of Furniture JC & F Services, Inc. Bloomberg Family Manufacturers J.T. Magen & Company Inc. Ted Bodin Florida District Kiwanis The Joachim Family Michele and Peter Bongiorno Florida Mushroom, Inc. Kenny Johnson Boston Properties, LP Fluor Constructors International, Inc. Joseph and Sally Handleman The Boult Family Foundation Fried, Frank, Harris, Shiver & Jacobson Foundation Trust Bovis Lend Lease, Inc. In Loving Memory of Fred Friedland Max D. Josephson* Bravo Brands Inc. Friends United for Diabetes Research Juvenile Diabetes Research Foundation Bristol-Myers Squibb Company Doree and Malcolm Fromberg International Dorothy and Michael Brumer Thomas E. Frueh* K&R Industries Buchwald Jewelers Anne Gache Kaback Enterprises, Inc. Marilyn Cahn Mira and Murray* Gaines Charlotte and Louis Kaitz Calvin & Flavia Oak Foundation Gardiner & Theobald Inc. Howard Kane Canyon Ranch Health Resort Fred Geller Electrical, Inc. Marsha and Arthur Katon The Carrion Family Gensler Joan and Myron Kaufman Cartier, Inc. Friends of Robert A. Georgine Kenneth A. Lattman Foundation Children With Diabetes Foundation Suzanne and Thomas Gerard Beth and Sy Kirshner Cathie and Robert Cornacchia Niety and Gary Gerson Merrick R. Kleeman CBRE Real Estate Services, Inc. Arnold Gertner Harry Klein* Lee and Sidney Charnin Bunchy Gertner Sheila and Arthur Kline Chase Enterprises Judy and Robert Giaquinto Knight Electrical Services, Inc. Elizabeth Cheval Susan and Arthur Gillin Gary Koenig, in memory of Deborah Chodrow G.L. Homes of Florida Corporation Walter D. Koenig Lori Dolce and Edwin S. Chua Dalia and Saul Glottmann Helene and Marc Kovens Cilco, Inc. Debora and David Goldfarb Debra and Jerry Kramer Citrix Systems Goldman Sachs and Company Alvia Kreher* Karen B. Cohen Bella and Lester* Goldstein Bertha Kubler Mr. and Mrs. Michael Cohen Lorraine Goldweber* L & K Partners, Inc. Ralph Cohen* Jennefer and Ian Goodman LandAmerica Vivian Cohen* Nettie Gratkowski* Laurie and William Landau Mabel B. Conklin Ellen and Irving Grauer Jill and Brian Landow Gertrude and Jack* Cooper Sylvia Gray Laro Service Systems, Inc. Miller Cooper George Green Lazard Freres & Co., LLC Lorraine and Sidney Cooperman Susan and Alan Habacht Lehr Construction Corp.

12 DIABETES RESEARCH INSTITUTE FOUNDATION Carole and Marvin Leichtung Rosalind and Daniel Richter Rina and Jerrold Weinbrom Jan and Arthur Leichtung Myrna and Norman Ricken Susan Blash Weiss and Gary Weiss Ellen and Joseph Leondis Marsha and Barry Ringelheim Wells Fargo Foothill Joan and John Leondis Heather and Charles A. Ritter Rhoda and Donald White Evelyn C. Levine Robert Stigwood Organization Marion and Robert S. Wilson Lodi Markets, LLC Deborah and Scott Robins Winn-Dixie Stores, Inc. JoAnn B. Long Loree Rodkin Marcia and Leon* Winograd Dr. and Mrs. John Lovecchio The Rothstein Family Sheila Wohl Francine Lowe Helen and James Rosburg Laurence G. Wolf The Luebs Family Harry & Bessye Rosenberg Marsha and Fred Wolinsky Alice Mace Charitable Trust Yates Restoration Group Ltd. Macklowe Management Co. Inc. Seymour Rosenberg In Memory of Lucian Zadrozny Margot Madans Blanche I. Rosenblatt Deborah and Jeffrey Zane Mailboxes, Etc. Mr. and Mrs. Maurice A. Ross Althea Brandner Zansler Jack N. Mandel Maritere and Jorge Rosso Mary Zuk* Diane and Paul Manning Ruth Rubenstein* Marino Gerazounis & Denise Rubin Jaffe Associates, Inc. Adrienne R. And Arnold J. Rubin *deceased Lisa and Richard Mattaway Alice and Seymour Rubin MC Energy Inc. Sager Development/Subway Linda and Bill McDonald, Jr. Saks Fifth Avenue Scott McDonald and Tiffany Schauer Salomon Smith Barney McGann Family Faryl and Jonathan Sandler Lois and Marvin L. Meitus Gerald P. Schein Mercedes Benz of Palm Beach Jill Schildkraut-Katz Joseph Messana Patricia and Leonard Schupak Metropolitan Steel Industries, Inc. Michele and Norman Seiden Linda and Thomas Meyer Barbara and Norman Shapiro Marge K. and Daniel H. Mintz Sanjiv Sharma and Nadine Allen Martha Mishcon Louis K. Sher Monster Worldwide, Inc. Show Management Concession Inc. Monterey Fund, Inc. Sheila and Joseph Shulevitz Edward Moss The Silva Family, in Memory of M-T-M Printing Co., Inc. Barbara Katz Stephen and Sandy Muss Lenore Toby Simmons and National Association of Letter Carriers Bernard Simmons National Distributing Company Casey and Matt Singer National Music Publishers Samuel Singer* Association, Inc. Dolly and Mitchell Sirgany Sheldon Neuman* S.I.U. of North America New York Elevator Company, Inc. Skadden, Arps, Slate, Meagher Ann and Jack Norman & Flom LLP Northland Cranberries, Inc. Bernadette and Owen Smith Novocell, Inc. Linda and Frank Smith Sandra Nowicki Sophia and William J. Casey Foundation Edward James Olmos Steelcase Inc. Otis Elevator Rhoda Stern Rosalie and Stephen Pandol Strauss Paper Company, Inc. Lisa and James Pappas Stuart Dean Co., Inc. Parents for the Cure Sugarman Family Partners in Natalie and Michael* Pelavin Memory of Fred Krutel* Perry Ellis International Inc. Cindy and Michael Sweeney David J. Peterson Team FootWorks Ruth Pfeffer Ted Moudis Associates Ruth and Nathan Plaks Temco Service Industries, Inc. Plaza Construction Corporation Tennessee Valley Authority Simon Portnoy Top Tomato Company Victor Posner* Tropical Shipping Hildine and Jerry Potashnick Union Bank of California, N.A. Premier Restoration Technologies, LTD. The Union Central Life The Produce Connection Insurance Company Prudential Financial United Food & Commercial Workers Norma and Luis Quintero International Union Raymond C. and Diane F. Radigan United States Sugar Corp. Rafa Machinery and Engineering VITAZEST Water – Triple A Products, LLC Real Estate Media Vornado Realty Joan and Gerald Robins Thomas J. and Holly C. Weger

2008 annual report 13 The Heritage Society The Heritage Society of the Diabetes Research Institute Foundation was created to recognize individuals who have generously made provisions in their wills, through life insurance, charitable remainder trusts and gift annuities, or other deferred giving vehicles to ensure that critical funding for the Diabetes Research Institute continues into the future. Over the years, planned giving programs have enabled many donors to make substantial gifts to the DRI in ways that have complemented their individual financial objectives.

Heritage Society members have chosen to create their own personal legacies and perpetuate their philanthropic goals for all those affected by diabetes. The following list includes those members of the Heritage Society through December 31, 2008.

Nancy Barr Bisco J. Jean Hacker* Kim and Beverly Newlin E. Diane Beber Kenneth G. Harple Eleanor J. and Thomas and Martha Blash* Shirley Harris Laurence S. Newman* Michele Bowman and Frances Harrow David Papier Joseph Underwood Larry Hassenbein In memory of Laurie R. Parham Annemarie and Lester Brockman Don and Diane Holmes Ruth Plaks Marty B. Bruder Shirley M. Hotto Betty Pinto* Jane D. Burt* Jill and Thomas Karlya Barbara C. Popp Henry Caballero* Carole and Barry Kaye Hildine and Jerome Potashnick Ivette and Juan Elias Calles Dr. Norman and Sue Kenyon James and Dr. Wendy Rapaport Jeanette Carmel* Richard H. Kline* Lillian Redlich Tom Curtis Eleanor Kosow Gertrude Reis* Aldo Del Re* Rose B. Kramer Margaret H. Reynolds* Cindi and Paul Elias Rebecca Krawitz* Jo-Ann Rifkind Eric Feiler* Sara Kupchik* Susan and Neil D. Rosenberg Carole D. Franklin Marc D. Levine Beatrice and William Sahm Sherrie and Joseph* Garfield Margot Madans Charles Sakele* Stanley J. Garfinkel Muriel B. Mele Arline B. Schaeffer Dr. and Mrs. Phillip T. George Jill and Gary Miller Maurice and Inge Schweizer* Elizabeth A. Guon* Howard C. Neumann Kimberly Schlom Seskin Family Foundation Barbara and Sheldon Singer Emilia M. Stark Gale Goldstein Tucker Ilene and David Vinikoor Simon H. and Sandra F. Waugaman Lori Chadick Weinberger Esther Weingarden Laura Weinsoff Lori and Lary Weintraub Susan Blash Weiss and Gary Weiss Julius Werbner* Adele Wilson* Sally D. Zak* Morris Zell Don Zipern Ann Zorn*

*deceased

14 DIABETES RESEARCH INSTITUTE FOUNDATION National Board of Directors

Chairman Directors Ramon Poo Thomas D. Stern Mark H. Ayers Michelle Robinson Bernard Beber, M.D. Ricardo Salmon Diane Beber Kenneth A. Shewer Chairman Emeritus Marlene Berg Kathy Simkins Marc S. Goodman Juan Elias Calles Sheldon L. Singer Brian Coughlin Jill Viner Harold G. Doran, Jr. Michael Wallock Vice Chairmen Nathan J. Esformes Sonja Zuckerman William J. Rand, M.D. William J. Fishlinger Charles Rizzo Jeanine Forman-Ham Douglas Gallagher Piero Gandini President and CEO Lawrence E. Glick Robert A. Pearlman Jay N. Goldberg Esther Goodman Jerrold Goodman Treasurer Arthur Hertz Barry C. Hauser Lawrence Howard, M.D. Bonnie Inserra Glenn Kleiman Secretary Martin P. Klein Steven Sonberg Eleanor Kosow Harvey M. Krueger Sandra Levy Allan L. Pashcow

2008 annual report 15 Honorary and Regional Boards of Directors

Honorary Board of Regional Boards Directors of Directors

Lynne and Martin Baron Florida Region Northeast Region Long Island Region Barbara and H. Tod Berman Paul Cejas Chairman Chairman Chairman John Drury William J. Rand, M.D.* Ricardo Salmon* Allan L. Pashcow* Annie Esformes Linda and Jay Finkelstein Directors Vice Chairman for Events Executive Committee Bernard Fogel, M.D. Sari Addicott and Public Relations Joan Fishlinger Edward T. Foote, II Bernard Beber, M.D.* Risa Pulver William J. Fishlinger* Samuel J. Fox Diane Beber* Barbara Hatz Lisa and Mark M. Freedman Juan Elias Calles* Directors John Luebs C. Thomas Gallagher Bruce Fishbein Philip Altheim** Hon. C. Raymond Radigan Gladys and Martin Gelb Jerrold Goodman* Barbara Annis Charles Rizzo* Linda and Barry Gibb Rene W. Guim Diane L. Cohen Yvonne Gibb Gary Hall, Jr. Peter L. DiCapua Directors Dwina and Robin Gibb Barry Hauser Kim Dickstein Bella Goldstein Barry Ballen Barbara Herzberg Joel S. Friedman Jane Goodman Michele Bongiorno Javier Holtz Richard M. Fuscone Senator Bob Graham Peter Bongiorno Norman Kenyon, M.D. Jay N. Goldberg* Mary Lou and Debra Carrion Vito La Forgia Marc S. Goldfarb Robert T. Held, Jr. John Carrion Sandra Levy* Esther Goodman* Fana and Abel Holtz Addy Fritzhand Micki Mele Marc S. Goodman* Lola and Donald Jacobson Jon Hatz Carol Nudelman, Ph.D. Alan Kava Stanley M. Kossoff Brian Landow Ramon Poo* Meryl Lieberman Robert Leichtung Jill Landow Christina Poo Samantha Shanken Sidney Levy Frances Luebs Deborah Rand David Sherr Charlotte and Louise Pashcow Michelle Robinson* Kenneth A. Shewer* Eugene Milgram Marie Rizzo Madelyn Rubin Steven Silva Martha Mishcon Miriam Shiff Rosa Schechter Thomas P. Silver Marge Kleiman Mintz Bruce Waller James Sensale Thomas D. Stern* Stephen Muss Roberta Waller Jacci Seskin Geoffrey L. Symonds Delia Whitton Judy and J.P. Newell, III Lou Steiner Edward James Olmos Don Strock *Also member of National Blanche Rosenblatt Board of Directors Gary Studley ** Honorary member Florence and Arnold Rubin Stephen Wagman Rowland Schaefer Rita Weinstein Donna Shalala Linda Widrich Weitz Serena and Leon J. Simkins Sonja Zuckerman* Oscar Sotolongo Ferne and Daniel Toccin *Also member of National Dottie and Jack S. Weiss Board of Directors Kelley Kosow Werner Lenny Wolfe hope

16 DIABETES RESEARCH INSTITUTE FOUNDATION Diabetes Research Institute Foundation Staff

National Office and Lauren Schreier Northeast Region Florida Region Associate Director of Public Relations Jill Ann Pall Robert A. Pearlman Special Events Director President and Chief Nicole Otto Executive Officer Assistant Director of Jill Salter Special Events Development Coordinator Deborah L. Chodrow Chief Operating Officer Lisa Heinowitz Jessica Gutierrez Special Events Coordinator Administrative Assistant Jeffrey Young Chief Financial Officer Natasha Norris Public Relations Coordinator Long Island Region Tom Karlya Vice President Laurie Cummings Anthony E. Childs Public Relations Assistant Long Island Regional Jill Shapiro Miller Director Vice President of Gift Planning Oneida Osuna Accounting Assistant Lily Scarlett Lori Weintraub, APR Director of Special Events Vice President of Marketing Denise Pereira and Communications Administrative Assistant Melinda Ginsberg Special Events Coordinator David Paikin, JD Mary Revie Florida Regional Director Administrative Assistant Margaret Cassani Administrative Assistant/ Barbara Singer Helen Segel Receptionist Director of Special Projects Executive Assistant

Sheryl Sulkin Mylinda Auguste Director of Special Events Data Entry Clerk

Brian Huether Marisol McKay Associate Director of Data Entry Clerk Special Events Lori Hester Kate McGuinness Receptionist Associate Director of Administration Eddy Garcia Courier Fx a e e r Tf - l l o e n o Th p e l e ,d o o w y l l o H e t i u S 0 0 2 a N i t 63 0 7 . 4 6 9 . 4 5 9 h t u o S 00 1 n o 7 3 4 3 . 1 2 03 0 . 8 . 1 l a k r Pa 0 4 0 4 . 4 6 9 . 4 5 9 L F O 1 2 0 3 3 e c i ff da Ro 0 1 4 g n o L e R Fx a e n o Th p e l e w e N e t i u S 1 8 3 ts a e h t r o N Fx a e n o Th p e l e o,h c i r e J e t i u S ww w n o i g k r Pa o h c i r e J 91 2 2 . 8 8 8 . 2 1 2 07 5 3 . 2 2 8 . 6 1 5 Y,k r o dn a l s I 81 1 1 10 2 d . b a i Y N e u n Ae v l a Y N s e t e 35 7 1 1 71 2 2 . 8 8 8 . 2 1 2 00 7 1 . 2 2 8 . 6 1 5 ek i Tp n r u O 61 0 0 1 ff a e s e r ht u o S se c i c r h r o . g

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