Diabetes Research Institute Foundation Summer 2010 / Volume 37 / Issue 2 Miami / New York / Long Island / California / Washington, D.C. DRI ocus fJoin us on social media sites!

Diabetes Research Institute Foundation Receives $5 MILLION GIFT FROM THE BUILDING AND CONSTRUCTION TRADES DEPARTMENT, AFL-CIO

The Diabetes Research Institute Foundation’s largest contributor, the Building and Construction Trades Department (BCTD) of the AFL-CIO, has pledged $5 million to be awarded over five years. This new gift brings the total dollars raised to more than $45 million over the last 25 years and firmly cements the unions’ commitment to help the Diabetes Research Institute find a cure for diabetes. According to Building and Construction Trades Department President Mark Ayers , the construction industry has been hit particularly hard by the decline in the economy, yet NEW Website, NEW Look, he attests that now is not the time to step away from the BCTD's commitment. MORE Features! “This dreadful disease continues to have a profound impact on people’s lives in Have you visited DiabetesResearch.org lately? If so, good times and in bad. Our members across the country subscribe to the belief that you’ve seen that we have completely redesigned ‘tough times never last – but tough people do,’ and our commitment to finding a our website to make it more dynamic and user- cure is enduring and unwavering,” said President Ayers. “We’ve come too far to friendly. After a year of development, the new site turn back now.” was launched with many new features and tools to offer a better experience and more information Continued on Page 3 for our visitors. Continued on Page 3

Honoring America Cure Thrift Shop Champions for Charity Draft Day Fundraiser Late Night DREaMS

Music legend Barry Gibb Cure Thrift Shop International designer New England Patriots Alan Kalte r, who has and Senior Airman Tre F. owner Elizabeth Wolff and actress Georgina Nose Tackle Vince Wilfork been the announcer for Porfirio were part of the welcomed pop singer Chapman , with Long threw his seventh annual the Late Show with unique tribute at this Lance Bass to her popular Island Regional Chairman Draft Day fundraiser for David Letterman for 15 year’s Love and Hope boutique in Manhattan Allan L. Pashco w, at diabetes research. years, served as emcee Ball, Honoring America. recently. Americana Manhasset. at DREaMS in the city.

> Articles on Pages 8 and 18 > Article on Page 14 > Article on Page 16 > Article on Page 19 > Article on Page 17 A Message from the Chairman $5 Million Gift from the BCTD Continued from page 1 Dear Friends, The work of our scientists remains at the highest standard, as This renewed support secures the BCTD’s for one reason. It is a disease that touches evidenced by the news we’ve shared in this issue. As you may have I hope the summer season has started off well for you. At the DRI continued participation in successful the lives of a vast majority of our members seen in the national headlines and through our email announce - 1 Foundation, we are closing out a challenging year and looking ahead fundraising efforts, such as the annual and their families in some fashion.” ments, Dr. Camillo Ricordi and his team saved a severely wounded with renewed optimism. Labor of Love golf tournament and the soldier from a life with diabetes, performing an historic islet trans - The reality is that nearly 24 million children DAD’s Day (Dollars Against Diabetes) cam - There is no doubt that the economic situation has had an adverse plant in collaboration with the Walter Reed Army Medical Center. and adults in this country have diabetes, and paign, which have been the cornerstone of effect on the level of our donations. Amidst the current financial The procedure was published in the prestigious New England more than six million people are already union fundraising efforts for decades. Beyond conditions we are seeing some bright spots, as many of our loyal Journal of Medicine . affected but have not yet been diagnosed. supporters have stepped to the plate to provide critical funds for financial support, the Institute’s state-of- We are also proud to report that several of our researchers received the DRI’s research. the-art research facility was constructed by “Standing behind the work of this brilliant honors and appointments for their significant contributions to the the hands – and hearts – of union men and medical team is simply the right thing to As you read in our cover story, the Building and Construction Trades field of diabetes, and our Kosow Diabetes Treatment Center received women from across the United States. do. With the Department having been a Department (BCTD) of the AFL-CIO has pledged an extraordinary an award for the highest patient ratings at the University of Miami supporter for so long, we feel that each step 2 $5 million. Despite the dire environment facing the construction Miller School of Medicine. “This is a partnership matched by no other. forward in finding a cure is something we industry, BCTD President Mark Ayers , Secretary-Treasurer Sean The Building and Construction Trades There is more good news to share, but due to space limitations can all share in. What we give, we get back McGarvey and the entire union membership recognize the urgent Department truly is the backbone of our we cannot fit everything on these pages. We invite you to visit our in knowing that we are a part of a winning need to fund our cure-focused research program. organization. They have raised millions of redesigned website, still at DiabetesResearch.org, where you can team,” McGarvey concluded. National Board members Marc Goodman , Esther Goodman and Ken register as a DRInsider and subscribe to our e-newsletters to receive dollars to construct and equip the Diabetes Shewer have announced a most generous $500,000 gift from their additional information and updates. Under development for the last Research Institute, and they continue to To learn more about the unions’ efforts to Stacy Joy Goodman Memorial Foundation. They are leading by example year, the new site offers more features, information and benefits fund our cure-focused research initiatives,” help the DRI find a cure for diabetes, visit and calling upon others to join them in supporting the DRI’s ongoing for you, our dedicated supporters. stated Robert A. Pearlman , president and ProjectTypeZero.org . Project Type Zero is an research priorities. Additionally, fellow National Board members Harold On behalf of every person and family affected by diabetes, thank CEO of the Diabetes Research Institute initiative created on behalf of the BCTD to Doran and Bill Fishlinger , on behalf of the Future Leadership Foundation, you for your ongoing generosity. As you know, it is needed now more Foundation. “The unions have made so benefit the Diabetes Research Institute, and it have recently made significant renewed commitments, as have the 1. According to BCTD President than ever and we hope we can count on your continued support of much of our progress possible, and this is has reinvigorated fundraising activity. Its mis - numerous donors who received Cycle of Discovery Awards. Mark Ayers, “Tough times never our mission to cure diabetes now . just another indication that they’re going sion is to unify efforts for state and local labor last – but tough people do.” Others, like Liz Wolff of the Cure Thrift Shop, our Diabetes Diplomats to see this job through to the end.” councils and their generous sponsors around Sincerely, 2. BCTD Secretary-Treasurer Sean and dozens of committed individuals who participated in our the country through increased communica - Building and Construction Trades Depart - McGarvey states that diabetes events, are doing what they can to raise much-needed funds. While tion and event support. With a community “touches the lives of a vast ma - ment Secretary-Treasurer Sean McGarvey the economy is impacting all of us, so is diabetes and it is imperative four million members strong, they truly are jority of our members and their that we come together to support the work of the DRI. Your dona - added, “The Diabetes Research Institute is families in some fashion.” the hope for a diabetes-free tomorrow. tions make research progress possible. Thomas D. Stern the Building Trades Department’s charity Chairman of the Board

1 2 1. Bruce Waller 2. Doug Donaldson NEW MEMBERS New Website Continued from page 1 In addition to re-organized content, sections and a brand DRInsider registration is free and once you’re signed up you’ll have TO SERVE ON BOARDS new home page, the site, which was built with the latest access to news updates, special promotions and event discounts, technology, includes: polls, surveys, and the ability to create your own profile. Thereafter, just log in before making a donation or registering for an event • an interactive event calendar and expanded Photo Gallery The Diabetes Research Institute Foundation co-chairman of the DRIF’s Crystal Ball. He contractors in the metropolitan area. and the fields will be pre-filled for easier transactions. is pleased to announce the appointment of and his wife, Long Island Board member Doug’s son, Matthew Ryan , was diagnosed • new event registration and donation forms You can also subscribe to DRIfocus: online plus two new enewsletters, two new board members. Roberta Waller , have been DRI supporters with type 1 diabetes at the age of 3. He • the ability to send eCards to commemorate holidays or pay Under the Microscope , covering research news and other happen - ever since their daughter, Dara , was diag - serves on the Crystal Ball and Empire Ball After serving on the Long Island Regional tribute to family members and friends ings around the DRI, and PEP Talk , from the DRI Foundation’s par - nosed with type 1 more than 20 years ago. committees. He lives in Laurel Hollow, NY, Board for two years, Bruce Waller of Upper ents’ group PEP Squad, which provides information and tips you It was Roberta’s father, Rowland Schaefer , a with his wife, Sheri . They have two other • links to join and follow us on Facebook and Twitter – and to Brookville, NY, has been elected to the can use today as a parent of a child with diabetes. So what are you member of the DRI Foundation’s Honorary children, Taylor and Tyler . share news and information with your own social media connec - National Board. He is the president of Gold waiting for? Visit DiabetesResearch.org today and stay on the Board and a Visionary of the organization, tions Coast Properties and Development, LTD, At its May meeting, the National Board inside track of the DRI and Foundation. who assured them that the DRI was the and of GW Development, LLC, and is in - also paid tribute to outgoing directors: • ways to create your own Diabetes Diplomats fundraising event best hope for a cure. Bruce and Roberta also volved in private real estate development, Bernard Beber, M.D. , Juan Elias Calles , right online (see story on page 5) have two sons, Andrew and Skylor . operation and management. Prior to this, Nathan J. Esformes , Jeanine Forman-Ham , • a new online community, DRInsider , that he served as an executive of a large private Douglas R. Donaldson was recently ap - Douglas Gallagher , Lawrence E. Glick , Jay N. affords numerous benefits for members, and manufacturing and import/export con - pointed to the Long Island Regional Board. Goldberg , Jerrold Goodman , Lawrence glomerate and as president of Décor, Inc. He is executive vice president for The Don - Howard, M.D. , Martin P. Klein , Michelle • a detailed gift planning section including Bruce is a member of the board at Congre - aldson Organization, a family owned busi - Robinson , and Michael Wallock . an interactive Life-Stage Gift Planner™ gation Teferith Israel, and he served as ness and one of the largest interior 3| LEAVING A LEGACY TO THE DIABETES RESEARCH INSTITUTE DON’T BE IDLE… THE LLOYD L. AND HELEN R. DILWORTH FOUNDATION BE THE HERO! Carefree beach days and kick-back vacations are the embodiment of summer. Yet, a number of families affected by diabetes won’t be so idle this summer. They’ll join American Idol finalist Kevin Covais by becoming Diabetes Diplomats and organizing their own summer fundraising project to support the DRI. As part of his efforts, Covais has created a series of public service announcements urging kids ADVANTAGES OF A and families alike, “Don’t Be Idle…Be the Hero!” PRIVATE FOUNDATION “I love being a Diabetes Diplomat, and summer is the perfect time for anyone to do a fundraising project. I can do what I like to do while supporting research for a cure at the Diabetes Research • Unlike a direct gift, which usually bene - Institute,” said Covais, who was diagnosed with type 1 at age 11. fits one recipient on one occasion, a pri - Diabetes Diplomats are a league of students, teachers, parents, grandparents and other family vate foundation perpetuates the members and friends who are taking the search for a cure into their own hands. They come from all donor’s generosity. Private foundations over the world and serve as advocates, educators and event fundraisers in their schools and neighbor - are excellent charitable tools for indi - hoods. Some have diabetes. Some don’t. But they have all decided to “Be the Hero” by helping to find a viduals and families who want to influ - cure for this disease that affects nearly 24 million children and adults in the U.S. alone. ence not only their own time and place, but the future. Rather than laze the days away, Diabetes Diplomats are making summer matter. Some are running marathons or planning neighborhood car washes or lemonade stands. Others are organizing garage sales or dress-down days • Private foundations play a vital role in American Idol at the office. Kevin Covais created his own fundraising page at DiabetesDiplomats.kintera.org/KevinCovais. Following in A family photo from the 1970s (l-r): Nathalie, Robert and John Reese, and Helen and Lloyd Dilworth supporting social, scientific and cultural Season Five Finalist his footsteps and also inspired by his mother, Miriam , who serves on the DRI Foundation’s Long Island regional board Kevin Covais has innovation. New ideas needed by soci - of directors, Tyler Shiff, 13, created a fundraising webpage, as well. He has already surpassed $2,600! ety change, and a private foundation joined the Diabetes Diplomats, the In Tenafly, NJ, Leo Gregory, 7, has also been motivated by his parents, Danielle and Troy Gregory , who have served as Originally from Chicago, Lloyd and Helen Dilworth settled in Miami Beach where they can embrace new ideas as they occur. fastest growing were very charitable and involved in many organizations. community aiming co-chairs for two events in the Northeast. Leo coordinated a project at his elementary school called Helping Hands. His • Personal benefits accrue to donors for the cure. fellow students were encouraged to purchase paper hands for $1 or more. They then decorated the hands and displayed After Lloyd’s passing, Helen established The Lloyd L. and Helen R. Dilworth Foundation who establish private foundations. them outside each classroom, helping to raise nearly $800. in 1987, with the help of her professional advisors. The plans specified that assets from Many donors regard private founda - Bobbi Price organized her family and friends into a team called Hope for Hunter, named after her youngest son who has Helen’s estate were to pass into the foundation upon her death. To ensure that her tions as enduring tributes to loved type 1, and participated in a community-wide walkathon in Duncansville, PA, led by Diabetes Diplomat Lisa Treese during wishes were carried out, Helen’s brother, Robert Reese , who is now deceased, and their ones – memorials that are vital, dy - the previous school year. Becoming a Diabetes Diplomat himself, Hunter arranged an event called Caps for a Cure at his close friend and accountant of more than 30 years, Alfred J. “Fred” Katzin , CPA, were namic entities. appointed as trustees of the foundation, along with an institutional trustee, which school. He made an announcement to the entire student body, and the next day anyone who gave him a donation for is now Wells Fargo. You will need an attorney to get started the DRI could wear a hat at school. Then, as his 10th birthday approached, Hunter nobly requested donations to the and to help with your application to the DRI in lieu of gifts for himself at his Bowling Birthday Bash. “By appointing an institutional trustee, Mrs. Dilworth was able to make certain that Internal Revenue Service as well as craft As summer fades and fall arrives, these families will be gearing up for more projects including walkathons at their her foundation would have the benefit of prudent, professional asset management your foundation’s governance docu - schools. You can easily coordinate one too with the help of the DRI Foundation! and administration responsible for carrying out her vision,” said Maria Mas Blet , senior ments – Articles of Incorporation and By- vice president and philanthropic consultant, Nonprofit and Philanthropic Services of Laws. The Council on Foundations Wells Fargo Private Bank. suggests that you consult a lawyer who For those interested in joining the Diabetes Diplomats and becoming a part of the fastest growing community aiming “With careful planning, Helen earmarked 80 percent of her foundation’s annual distri - has expertise in nonprofit tax law. for the cure, visit DiabetesResearch.org/DiabetesDiplomats butions to benefit five organizations that were important to her. Her brother Robert or email [email protected]. had diabetes, which prompted her to include the Diabetes Research Institute Foundation among the charities that will continue to benefit from her generosity in perpetuity. The remaining 20 percent of the distributions are made at the discretion of the Tap into the powerful new Leo Gregory adds foundation’s trustees,” explained Mr. Katzin. a high five to his resources of the gift planning classmates’ Helping Diabetes continues to impact Helen’s family. Her nephew, John Reese , now 63, has been section of our website. Hands. diagnosed with diabetes. Her foresight and ability to provide funding for the Diabetes Research Institute’s cure-focused, patient-centered research may one day help John • Learn about tax benefits you’ll reap Hunter Price and his and the millions of children and adults living with this devastating disease today, as from various types of gifts friend, Wyatt, collect donations on Caps well as in generations to come. • Read about how-and why- others have for a Cure day. “Through the vision and generosity of extraordinary people like Lloyd and Helen Dilworth, made gifts to the DRIF Tyler Shiff created we have made significant progress in the fight against diabetes,” said Robert A. Pearlman , a fundraising page, president and CEO of the Diabetes Research Institute Foundation. “We are eternally • Match your personal situation with the and you can too! grateful for the legacy gift from The Lloyd and Helen Dilworth Foundation, which helps right gift for you with the interactive to take us one step closer to a permanent cure for diabetes.” Life-Stage Gift Planner™ Visit www.dri.giftplans.org today!

5| DONO R LEVEL AWARD Visionaries $10,000,000+ Innovation Chairman’s Council $5,000,000+ Validation Leadership Council $1,000,000+ Perpetuation FOUNDATION DONORS Governors’ Society $500,000+ Translation Distinguished RECOGNIZED Humanitarians $250,000+ Realization Awards from the DRI Foundation’s Cycle of Discovery series were presented to Grand Founders $100,000+ Exploration donors who recently made major gifts . The award program corresponds with LEADING THE WAY Founders $50,000+ Hypothesis the Foundation’s cumulative giving designations. National Board Members Step Up for the DRI, Inspire Others Benefactors $25,000+ Query

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When faced with a monumental challenge, most people look to “The economic problems of the last two years have adversely those who lead for direction and assurance. Just two years ago, as affected charitable giving across the board, including donations the economy began its downward spiral severely impinging upon to the DRIF. As a result, our revenues have been diminished, but the contributions to not-for-profit organizations, including the Diabetes need to find a cure for diabetes has not. Families still live with this Research Institute Foundation, eyes turned to the National Board of insidious disease every day, and every day they hope and pray for Directors for leadership and guidance. And once again, they re - a cure,” said Harold, who serves as treasurer and made a gift of sponded, with the same passionate commitment that has embod - $400,000 earlier this year, along with his wife, Kelly . Their son, ied this unique organization from day one: an unwavering promise Will , was diagnosed with type 1 as a toddler in 1994. 5 6 7 8 to cure diabetes now . “Kelly and I know that the work of the DRI must continue toward A Generous Gift Challenge this goal,” he said. “And we believe during these tough economic times it's more important than ever that we increase our invest - Leading the way, Chairman Emeritus Marc Goodman and fellow ment in this cause.” board members Esther Goodman and Ken Shewer decided they would support the DRI and try to encourage and motivate others. Similarly, Bill stated, “My wife, Joan , and I felt it was a good time Through the Stacy Joy Goodman Memorial Foundation (SJGMF), to make a statement about how committed we are to the DRI. The named in memory of Marc’s daughter, they committed $500,000 research being conducted at the Institute is the best available to to fund the Diabetes Research Institute’s priority research programs move the marker toward finding a cure for our daughter and for aimed at restoring natural insulin production in those with type 1 the millions living with this disease.” diabetes. Their goal is to stimulate additional gifts at a time of The Fishlingers, who have been involved with the organization since 9 10 11 12 great opportunity – and great need. their daughter, Alex , 22, was diagnosed at age 6, made a gift of “We knew we wanted to do something, but at the same time, I was $250,000 through the Future Leadership Foundation. compelled to encourage others to give in any way that I could,” Marc “I think anybody that has the means to contribute – in any amount or stated. Ken, Esther and Marc founded the SJGMF after Stacy Joy trag - in any way – should do so when the need is greatest, and that’s now. ically lost her battle with diabetes at the age of 17. Ever since, they To interrupt research because of economic times is a tragedy,” he said. have been driven to relentlessly pursue a cure for this disease. The DRI Foundation extends deepest gratitude to all board leaders, “We believe that we are close to finding a cure, and that the DRI with hope that the momentum being generated will carry on and will be one of the leaders getting us there…There’s not a day that multiply, as the Diabetes Research Institute continues leading the goes by that losing Stacy doesn’t hurt as much as the first day. I world to a cure. want to spare each family the pain I’m living with, and do whatever 13 14 15 16 I can to make that day sooner rather than later,” said Marc. Other Exemplary Gifts Also stepping up to the plate, National Board members Harold Doran and William (Bill) Fishlinger have made significant contribu - tions to the DRI recently.

PERPETUATION AWARD: (1) Jill and Cliff Viner, with DRIF President Robert A. Pearlman. TRANSLATION AWARD: (2) Joan and William Fishlinger REALIZATION AWARD: (3) Fran and Mel Harris, (4) Francine Lowe . EXPLORATION AWARD: (5) Roberta and Dr. Harvey Chaplin, (6) Sue and Dr. Norman Kenyon with Pearlman, (7) Roy Ripak, market vice president (l-r): Marc Goodman, of Walgreens, with DRIF Vice President Tom Karlya. Ken Shewer, Esther Goodman, Harold Doran, William Fishlinger HYPOTHESIS AWARD: (8) Joan Galison (center) accepting the award from Mariana Sherman (left) and Renee Aronin , (9) Michael Perlmutter , and his wife, Marlene (not pictured) (10) Lenore Toby-Simmons and Dr. Bernard Simmons . QUERY AWARD: (11) Peggy and Joseph Armaly, (12) Suzanne and Don Bezahler, (13) Deborah Chodrow , (14) Marion and Dr. Donald Golden, (15) Madeline and Herbert Hillsberg , (16) Donna and George Zoley, president of The GEO Group, Inc. 7| AMERICAN SOLDIER SEVERELY WOUNDED IN AFGHANISTAN RECEIVES HISTORIC ISLET CELL UNDER THE TRANSPLANT MICROSCOPE A 21-year-old airman severely injured while serving his “Isolation and purification of pancreatic islets is a very with Norma Sue Kenyon, Ph.D. country in a remote area of Afghanistan lived to see the intricate procedure which requires a specialized labora - birth of his son after recovering from several surgeries tory, and there are only a few such facilities in the and an unprecedented islet cell transplant that saved United States,” said Dr. Jindal. “I knew the Diabetes At the DRI, we’re working to discover a biological cure for type 1 Q. Since that initial discovery, how has your study of MSCs evolved? diabetes. To accomplish this, we are pursuing approaches to elimi - him from a life of severe diabetes. The Diabetes Research Research Institute at the University of Miami Miller A. Follow-up pre-clinical studies continue to confirm our initial nate autoimmunity and permanently restore the natural ability to Institute played a major role in this unprecedented School of Medicine had such a facility, and I put a call findings. It’s just astonishing to me how, with a small amount of sense blood sugar and release the precise amount of insulin to surgery, and the New England Journal of Medicine in to its director, Dr. Camillo Ricordi , for his assistance in islets, we’re able to reduce dependence on insulin. The results are maintain normal glucose levels. highlighted the historic event. isolating the islets from our airman’s removed pancreas.” encouraging and that work continues. At the same time, we’re col - We have already shown that replacing the lost insulin-producing laborating with the DRI Tissue Engineering Team to incorporate “I almost died – twice from loss of blood – and once Dr. Ricordi, world renowned for developing the method to islet cells can give patients back the ability to naturally produce MSCs into engineered structures designed to house and protect from the problems with my pancreas,” said US Senior isolate islets from the pancreas, immediately agreed to insulin. While we are extremely encouraged by this progress, we’re insulin-producing cells. Airman Tre F. Porfirio , whose entire abdominal cavity help. In his words, “Anything to help a wounded warrior.” continuing to overcome the remaining challenges. needed to be restructured. “I had a child on the way. Q. What are the next steps? The organ was removed and shipped from Washington, Among these is the need to limit the inflammation that occurs That is all I could think about [when I was shot.] A. We are learning more about how MSCs work by tracking their D.C., to Miami, where members of the DRI team spent after transplantation. When you get a splinter in your finger, the I thought I was done.” movement. Thanks to funding from our Diabetes Research Institute six hours isolating the insulin-producing islet cells from skin around it usually turns red and becomes inflamed. That’s our Foundation, we’ve been able to collect preliminary information on After being struck from behind by three high velocity the airman’s pancreas. The islets were then flown back, immune system at work trying to protect us from germs that how to track these cells using magnetic “markers.” Having an bullets on November 21, 2009, Tre was operated on twice and Dr. Ricordi assisted Walter Reed surgeons via the could harm our bodies. That response – the inflammation – also understanding of where the cells go and what they do is key to in field hospitals and then air lifted to Walter Reed Army Internet in successfully infusing the isolated cells into happens when insulin-producing islet cells (or other tissues) are conducting safe and effective clinical trials. Medical Center, where he came under the care of Tre’s liver on Thanksgiving Day. transplanted into a patient. The problem is that inflammation can Dr. Craig D. Shriver , chief of general surgery. adversely affect the survival and function of the islet cells. So, Q. What other challenges remain as you explore the potential of “It makes me feel good that while we are fighting to scientists here at the Diabetes Research Institute are trying to MSCs as an effective therapy for diabetes? “The optimal procedure at this point was to remove his find a cure for a disease that affects 240 million world - find ways to reduce or prevent this inflammatory response. entire remaining pancreas to prevent further leakage of wide, we can actually help one person at a time when A. We know that not all MSCs are created equal. You can look at the pancreatic enzymes and control the bleeding, which the occasion presents itself,” said Dr. Ricordi. The DRI’s Dr. Norma Sue Kenyon , Martin Kleiman professor of sur - the surface of the cell and say it has the right shape and appear - could be fatal,” said Dr. Shriver. “We knew that the proce - gery, microbiology and immunology, and biomedical engineering ance under the microscope, but that doesn't mean it’s manufac - “There’s no other patient in the world who has had their dure would lead to the most severe and life-threatening at the University of Miami, is leading the effort to reduce inflam - turing all those wonderful molecules that are anti-inflammatory. entire pancreas removed for trauma, survived, and had form of diabetes, which tends to be very brittle and diffi - mation. One promising area of focus is on Mesenchymal Stem So, if you just take a population of cells and start transplanting the pancreas islet cells put back in the liver and have cult to control in this type of situation.” Cells (MSCs) – which Dr. Kenyon and her team discovered have a them, you’re going to get a mixed bag of results. One of our next them function 100 percent perfectly. Tre is not on any beneficial effect on transplanted islets. MSCs are found naturally, goals is to characterize MSC cells — to clearly identify which ones Dr. Shriver then sought the opinion of Dr. Rahul Jindal , insulin. His sugars are normal. He really is a one-of-a- in our body’s own bone marrow and have the unique ability to not make the necessary molecules and, as a result, determine which a transplant surgeon at Walter Reed and a clinical kind case,” stated Dr. Shriver. only reduce inflammation, but repair damaged tissue and stimu - MSCs are optimal for use in clinical trials. professor of surgery at George Washington University late the growth of blood vessels. They may also play a role in the “Tre is a hero,” Dr. Ricordi said. “He risked his life in the Q. What is your ultimate hope for the use of MSCs to cure those in Washington, D.C. Dr. Jindal had training and experi - survival and function of insulin-producing cells. For all these rea - war against terrorism, and it’s a miracle he is alive.” now living with diabetes? ence in islet cell transplantation. sons, it’s believed MSCs can enhance the use of cell-based In March, Tre’s fiancée gave birth to a healthy baby boy. therapies for the treatment of diabetes. A. These naturally-occurring cells have the potential to benefit In islet cell transplantation, the insulin-producing islets diabetes patients in many ways. First, if MSCs can reduce or pre - Q. How did you first discover Mesenchymal Stem Cells (MSCs) had are isolated from a donor pancreas and then re-infused in To watch a video on this remarkable story, visit vent the inflammation that occurs after transplantation, we can potential as a therapy for the treatment of diabetes? a patient’s liver, where they later begin to produce insulin. DiabetesResearch.org/SoldierVideo enhance the long-term viability of the islet cells needed to restore A. Many years ago, we conducted a study to see if donor bone natural insulin production. Secondly, when more cells survive, marrow cells (DBMC) could be used to help diabetes patients better fewer will be needed for transplant - perhaps as few as one third 1 2 tolerate transplanted insulin-producing cells. At the time, little was the islets we use now - which is critical because one of our other known about MSCs and the primary goal of that study was to deter - great challenges is that donor tissue is in short supply. And finally, 1. Drs. Ricordi, Shriver and mine if MSCs, given intravenously with the bone marrow cells, could there’s also evidence that MSCs can reverse rejection, which means Jindal at Tre Porfirio’s enhance bone marrow engraftment. Because they were believed to we may be able to use them to lower the amount of immunosup - bedside post transplant. have anti-inflammatory properties, we also decided to co-transplant pression (anti-rejection drugs) that islet transplant patients must MSCs with islets to see if they could prevent the inflammatory re - now take long term. 2. Dr. Ricordi, Tre and sponse associated with transplantation of islets into the liver. We Dr. Shriver were honored at the DRIF’s Love and discovered that the MSCs did have a positive impact on islet func - Hope Ball. (Dr. Jindal was tion. In that pre-clinical study, recipients that received MSC/islet co- unable to attend.) Read transplants had more than double the levels of c-peptide production more about the Ball on compared to those that received islets alone, indicating increased page 18. insulin production and better functioning islets.

9| AROUND THE DRI KOSOW CENTER DRI’s Dr. Kenyon Honored as a CAMILLO RICORDI, M.D. , Earns Top Rank by Patients Inducted into Prestigious Association After a survey of patients by the University of Healthcare Hero Miami Medical Group, the Kosow Diabetes Treat - ment Center at the DRI was recognized with an In the diabetes community, the DRI’s Norma Sue Kenyon, Ph.D. , has always been a hero. award for the highest patient ratings at the And in May of this year, she was given the title in an official capacity at the Greater The new AAP inductees are from left: Richard University of Miami Miller School of Medicine. Miami Chamber of Commerce’s annual event, the Healthcare Heroes Awards. Cote, M.D., Camillo Ricordi, M.D., Antonio Bianco, Winning the Bio-Medical Award, Dr. Kenyon was recognized for her research in trans - M.D., Ph.D., and Joyce Slingerland, M.D., Ph.D. “This validation and acknowledgment by you, those we care for and about, means so much to plant immunology, specifically using biological replacement therapies for patients with each of us,” stated Dr. Luigi Meneghini , director. type 1 diabetes. The DRI Foundation congratulates each and While accepting the award, she thanked the DRIF for helping to “seed the research DRI Scientific Director Dr. Camillo Ricordi , together with three other every person at the Kosow Center for providing and provide the funding to get things started. In the end, it’s all about translating all physicians from the University of Miami Miller School of Medicine, was an exceptional level of care. the wonderful discoveries at the Institute in Miami to the bedside of the patient.” inducted into the prestigious Association of American Physicians (AAP), founded in 1885 for “the advancement of scientific and practical The Healthcare Heroes Awards recognize individuals, institutions and programs, who, medicine.” Induction is considered a great honor as members have in - through their individual or collective actions, have made an extraordinary impact in the cluded Nobel laureates and members of the National Academy of DIABETES AND South Florida healthcare community beyond the scope of their jobs. Dr. Kenyon joins a Science and the Institute of Medicine. handful of esteemed colleagues who have received the award previously, including the TELEMEDICINE UPDATES DRI’s scientific director, Camillo Ricordi, M.D. They were inducted during the organization’s annual meeting in Chicago on April 24. for Caribbean Health Leaders Dr. Kenyon is the director of the Executive Research Council at the Diabetes Research Institute, the Martin Kleiman professor of surgery, microbiology and immunology, and “It is an incredible accomplishment to have four faculty members from Doctors from the Diabetes Research Institute biomedical engineering at the University of Miami, and director of the Wallace H. the same institution inducted into the AAP at the same time,” said teamed up with the University of Miami’s Coulter Center for Translational Research. Pascal J. Goldschmidt, M.D. , senior vice president for medical affairs Miller School of Medicine TeleHealth Program and dean of the Miller School and CEO of the University of Miami Health System. “All four inductees are stellar physician-scientists who have to give a seminar on telemedicine and diabetes contributed greatly to the advancement of science in their chosen fields.” for health leaders of seven Caribbean nations, hosted by the Florida State National Guard ear - “It is an honor to become a member of such a prestigious society. As the only surgeon accepted this year and one of the few ever inducted, I am lier this year. Held on the medical campus, the extremely grateful to the AAP selection committee for the consideration and recognition,” said Dr. Ricordi. “I accept this great honor on behalf of all two-day event focused on the diverse applica - of the outstanding scientists and staff of the Diabetes Research Institute who have made our work and progress toward a cure possible.” tions of telemedicine and on diabetes. Dr. Norma Kenyon said that “it takes Dr. Ricordi is considered one of the world’s leading scientists in cell transplantation, and is well known for developing the automated method a village” to achieve greatness in One of the presenters, Luigi Meneghini, M.D., for islet cell isolation called the “Ricordi Method.” The procedure makes it possible to isolate large numbers of pancreatic islets and is now used healthcare. M.B.A. , director of the Kosow Diabetes Treat - by laboratories worldwide performing clinical islet transplants in patients with type 1 diabetes. Dr. Ricordi led the team that performed the first ment Center at the DRI, said he “appreciated series of successful clinical islet transplants in 1990. the opportunity to share information on the use of advanced technology for the manage - ment of diabetes.” Member nations of the Regional Security Serv - DRI TO PRESENT ALTERNATIVE TRANSPLANT SITE RESEARCH DRI SCIENTIST ASSUMES LEADERSHIP ROLE ice (RSS) attended the event at the invitation of Dr. Norma Kenyon is part of a team of DRI researchers whose work in identifying alter - in Global Research Project the U.S. Embassy in Bridgetown, Barbados. native sites for transplanted islets has been selected for presentation at the prestigious Participants received an overview on providing Transplantation Society's 23rd Congress in Vancouver, Canada. Dr. Alberto Pugliese , who leads the Immunogenetics program at the Diabetes Research Institute, health care remotely and in-depth presenta - Together with DRI's scientific director, Dr. Camillo Ricordi and Dr. Cherie Stabler, director of has been named a director of the network for Pancreatic Organ Donors with Diabetes, or nPOD. tions in several specialties. the Institute's Tissue Engineering program, Dr. Kenyon and colleagues are exploring the nPOD is a collaborative effort between academic institutions, organ procurement organizations “We were able to unite a dozen key health care potential of biohybrid devices called “scaffolds” to house and protect transplanted insulin- and leading diabetes researchers from around the world. Its goal is to support scientific investi - professionals, increase their knowledge of ap - producing cells. The three-dimensional devices, developed by the DRI, are designed to gators by providing, without cost, rare and difficult-to-obtain tissues beneficial to diabetes proaches to a significant public health issue in closely mimic the natural pancreatic environment and are being tested in several sites in research. nPOD currently supports over 50 type 1 diabetes-related scientific studies at their region, and discuss the advantages and the body, such as under the skin, in muscle tissue and in an abdominal “pouch” using the institutions around the world. issues associated with telehealth applications body's own vascularized tissue. In addition to providing structural support for the islets, a for diabetes and other specialty care,” said recent study shows the scaffolds can also be used to deliver beneficial agents (other cells) Dr. Pugliese is also a member of several other international research programs including Type 1 Anne E. Burdick, M.D., M.P.H. , associate dean for to further increase the viability of transplanted cells. In the pre-clinical trial, the agent/islet Diabetes TrialNet and Type 1 Diabetes Genetics Consortium. His research has been published in telehealth and clinical outreach and professor combination resulted in insulin independence in one study model, and others are currently major international journals, including Nature Genetics, Nature Immunology, Journal of Clinical of dermatology and cutaneous surgery. being followed to determine if they can also achieve insulin independence. Investigation, Lancet , among other prestigious, peer-reviewed journals. By participating in the seminar, each partici - The results of the study are encouraging. The silicone-based “scaffold” continues to show Alberto Pugliese, M.D. pant will be a resource for their respective na - potential as an environment where transplanted islets can thrive, and may represent an tion in planning and implementing advances important step toward our goal of achieving long-term success with islet transplantation. in health care. 11 | Use your measuring tools at home so you’ll do better PEP TALK “swagging” while you’re out. DO YOU WAKE UP IN THE MIDDLE OF THE NIGHT TO TEST YOUR CHILD ? What the DRIF’s PEP Squad (Parents Empowering Parents) has found is that “diabetes parents” aren’t just looking for the right answer or the best practice when it comes to taking care of their children. Parents are also looking for support, for a sounding board. They need to let out their frustrations, be heard, and know that they’re not alone. It's all part of the “new normal.” “SWAGGING” So, the PEP Squad took the conversation online – to Facebook, where more than 400 parents have joined the group – and it’s growing each day! Every Monday, members discuss a new topic. A few excerpts from this recent discussion: MADE EASIER!

Lisa: I wake up every night! Zach doesn’t wake up for finger pricks but normal blood sugars without the introduction of food. I do go right In the last edition of this newsletter, the terms “WAG” (wild ass guess) and “SWAG” (scientific wild ass guess) were does if I have to change his pump site. I do NOT fall back to sleep and back to sleep, most nights with the help of a meditation tape down - discussed, with SWAG being the preferred method of calculating carbohydrate intake. So, in the interest of making mostly worry about his numbers all night long! If I wake for any other loaded on my iPod. Works like a charm. I never finish the whole program. you all better “swaggers,” let’s see how you can accomplish that goal! reason, I can’t fall back to sleep unless I go check him. Jennifer: We always check around 12am. If the numbers are not Katy: We check every night at about 2am. Alex always seems to where we think they should be, then I stay up. I can never go to sleep The more conventional method of using a carbohydrate counting book, for example, The CalorieKing Calorie, Fat and Carbohydrate Counter (quite be sound asleep but as soon as he hears the beep, he always asks, when her numbers are out of wak. I figure that since I don’t work, the best and most comprehensive reference we have found and also available online) is very helpful but requires you carrying a heavy little book “What's my sugar?” He has been on a trend of running somewhat after the kids go to school, I sleep a bit. Part of the job for me! Before around. In today’s “techie” world there are several devices and applications designed to make life easier. high through the night so, when I go back to bed, I lay there and worry major exams I usually pull all-nighters, definitely new meaning of about what can be done to get his numbers back in range. I actually all-nighter. LOL. I have watched some great movies over the years!! The Palm Pilot used to be the most popular hand held device with the availability of several applications to help you count carbohydrates and don’t think I’ve had a full night of sleep since diagnosis 8 months ago. better manage your dietary intake. However, the iPhone now seems to be the most popular with a variety of “apps” available. Other phones include Bonnie: Before we had a CGMS, I would check my daughter at least at the Palm Treo and Blackberry. Jeff: Only when we change the amount of insulin that we give him 12am and 3am, more sometimes, depending on what was going on do I check him in the middle of the night. If I do, he usually doesn’t that day. Now, I rely on the high and low buzzers to wake me - lots of For those who prefer a separate device, the Track3 Diabetes Planner, Carb Counter and Insulin Calculator may be the answer. This electronic hand - wake up. If it is okay, then I am able to go back to sleep fine. nights there are more buzzes and I get LESS sleep than before, but I held diabetes planner helps you stay “on track” with carbohydrate counting and insulin dosing, as well as exercise and logging data. For $79.99 am ok with that because I know that we are catching everything. online, it has nutrition information for more than 50,000 foods and 250 restaurants. Wendy: We check Jeremy at least 2x’s a night. Luckily he usually doesn’t wake up!! He does stick his finger out in his sleep. That always Rachel: I have been waking up to check my son in the middle of the The EatSmart digital scale ($65.00 online) has a database of 999 common foods and will do the carbohydrate calculations automatically based makes me sad that even while he is sleeping, he is still always aware night for years...Sometimes I can go right back to sleep & sometimes on the weight of the food. Perhaps a little expensive, but a good choice for a birthday or anniversary present! of his diabetes. His conversations in the wee hours though when we I can’t. Just one of the fun things w/ T1D, no? LOL! Cole NEVER wakes Those readers who use the Animas insulin pump know that incorporated into the pump menu is a food list of 400 items. This food list can be have to wake him up for lows are precious. up...He sleeps through anything! personalized by using the EzManager software, allowing you to delete those foods you have no intention of ever eating, and adding those favorites Deborah: We have come to depend on the CGM alerts. When it isn’t Cindy: My granddaughter, Ashley, was diagnosed March 2003, and that were not originally included. giving readings because it hasn’t calibrated yet, I have to set my in - we have NOT missed a night yet and never will. It is a family effort. Carbohydrate counting will never be an exact science, and understandably, it can sometimes be extremely frustrating. Consider that there may ternal alarm clock...and then I pop up a few times a night to check. My daughter works nights a few times a week, and when I babysit, be other factors coming into play, besides what you put in your mouth, stress, illness, activity, insulin on board, all of which affect blood sugar levels. Heavy breathing and shallow breathing are my cues that numbers she calls me to test her. (Sometimes several times a night!) Remember, using your measuring tools at home will improve your ability to better “eyeball” portions in a restaurant and together with the devices are off.....Sleep? What’s that? Join the PEP Talk on Facebook. mentioned above may help to simplify and lessen the time required to count carbs and stay in good control. Beatriz: We check Rachel every night. It’s part of the “new normal” since Visit DiabetesResearch.org/PEPSquad for the direct link, or search she was dx 9 1/2 years ago. I figure that the nighttime can provide a “PEP Squad” under “Groups” on Facebook. window for Rachel to get a good 12 hours of normal or at least near-

Overnight hypoglycemia is often one of the to the insulin that is required to match the feed basal insulin with carbs to prevent hypo - If hypoglycemia does occur, then the best JUST ASK greatest fears of parents of children with diabetes. glucose output by the liver). If the basal level glycemia. And, children should generally not thing to do – hold on, here comes the math – It is of such concern that many parents feel the is fine, then blood glucose levels should be need snacks at bedtime to prevent hypo - is to administer 15 grams of rapid acting need to check blood glucose levels at least once stable and not go high or low during the glycemia – except if exercise causes delayed glucose and recheck your child’s blood sugar KELLIE in the very early hours of each morning – and overnight hours when your child is asleep. lowering of the glucose level. level in 15 minutes. Do you have a question about a particular some even more throughout the night. If blood glucose does go low, it means the If your child participates in sports or physical Of course, too many times I hear, “But they diabetes-related topic? Are you trying to navigate The true answer to avoiding hypoglycemia is to basal insulin dose is too much and needs to activities that lower his/her blood glucose level, were tired and went back to sleep.” Too bad! through all of the information – and misinforma - prevent it from happening in the first place. So be reduced. This is very surprising to parents then you may want to give him/her a long last - Safety is key. Remember, you must first take tion – out there? Just ask Kellie Rodriguez, M.S.N., the first step is to identify the reason why your because it is often believed that the glucose ing, slow releasing snack before bedtime that preventative steps to reduce the risk of hypo - C.D.E., C.P.T. , director of patient education at the child might be going low and to reduce the risk level will go low if their child doesn’t eat. does not require insulin coverage, like milk (es - glycemia and then act quickly should it occur. Kosow Diabetes Treatment Center at the DRI. To of that occurring. Usually, hypoglycemia is a re - Thankfully, we now have much better insulin pecially high fat), crackers or bread with peanut submit your questions, email [email protected] . Note: The material in this newsletter is for informa - sult of excessive insulin amounts or exercise and choices and insulin delivery mechanisms that butter, Extend® bars, or Glucerna® bars that tional purposes only and is not intended to consti - Q: I wake up multiple times a night to test my the good news is that both can be addressed. help to meet the overnight basal insulin have delayed glucose absorption (the bars con - tute medical advice. Every patient is different. DRI’s Director of Patient Education child. What can we do to avoid hypoglycemia at needs more physiologically. tain cornstarch). If your child is on an insulin Always consult your physician or other qualified The first step is to make sure that your child’s health provider for diagnosis and treatment of Kellie Rodriguez, M.S.N., C.D.E., C.P.T. night, and if it happens, what’s the best way pump, using the “temporary basal” feature and basal insulin dose is correct (basal insulin refers The key point is that you should not need to any health related matter. to handle it? lowering the basal insulin rate may work.

13 | EVENTS Although Liz feels lucky to be able to keep her diabetes under Throughout the year, so many events far and wide support the Diabetes Research Institute. Following is a control, her heart goes out to so many others suffering with com - sampling of previously held events. For complete coverage, visit DiabetesResearch.org. plications. She fervently encourages others to pitch in. For Cure Thrift Shop, she says, merchandise is the key. “We are in the busi - ness of donations. We need product -- not just from families, but from corporations too.” CAST-OFFS IN; TREASURES OUT DRI supporters like, Samantha Shanken Baker , Diane Cohen , Esther and Marc Goodman , Risa Pulver , Ricardo and Leslie Salmon and Tom Carnival for a Cure / Kids Party for a Cure FOCUS ON FAMILY and Denise Stern have already contributed high-end furniture, cloth - What kind of job do you have if you wear the hat of a truck driver ing, hand bags and more. Other than gently-used household items, and mover in the morning and that of a fashion merchandiser for On Sunday, March 7, the DRI Foundation Ricardo, who also serves as the DRI Founda - Bouncing from one thing to the next, kids Liz welcomes corporate offerings such as overstock from a retailer or offered dual family-friendly fundraisers in tion’s Northeast Regional Board chairman. and parents enjoyed all of the venue’s excit - celebrity shoppers in the afternoon? For 26-year-old Elizabeth remnants of last season from a designer. Even damaged or extraneous Wolff the answer is simple: the perfect job! New York. Conveniently located in Manhattan “It’s heartwarming to know that so many ing offerings – from video and arcade games pieces can be transformed by Liz and her talented staff with just a and on Long Island, respectively, Carnival for a supporters believe as I do that the DRI is the to inflatable toys, bowling, pool tables and “It’s my entire life. I love what I do,” said the owner and operator of sewing kit or a few tools. Cure and Kids Party for a Cure raised more best hope for a cure.” more. Amidst the revelry, they stopped and Cure Thrift Shop. “I am at the shop seven days a week, and I even go than $450,000 for the DRI this year. enjoyed a wide selection of food and bever - Because Cure Thrift Shop is filled with treasures from many differ - Carnival attendees of all ages enjoyed virtual on the furniture donation runs.” ages to please all palates. Participants took ent families, it is apropos that Liz’s own family is often onsite, Co-chaired by Danielle and Troy Gregory , reality games like Guitar Hero and Rock Band, home goody bags, as well as fantastic prizes Barely two years old, the Manhattan-based store is already a mecca showing their support of her passion project. Her husband, Marty , Holly and David Sherr , and Leslie and Ricardo sports like basketball, mini auto racing and won through raffles and a silent auction. for fashion mavens and celebrities, attracting noteworthy shoppers a physician, frequently arrives in scrubs after his shift to man the Salmon , the fifth annual Carnival for a Cure jousting, and new this year, a CD Recording such as Lance Bass, Mary Kate Olson, Brooke Shields, and Natalie register. Her parents and siblings are always helping out, and even attracted more than 800 guests to The Puck Booth, a Wax Hands Booth and a Bungee Bull. “It might seem a little chaotic with all the Portman . Gabe Saporta of the popular band, Cobra Starship , practi - her 6-year-old niece helps out by “Windexing.” Building in lower Manhattan. It was at this Also on hand to entertain were face painters, kids and games, and that’s exactly what I love cally furnished his apartment with purchases from Cure Thrift Shop! “It just feels like home. There's a real sense of love all around,” Liz event three years ago that Nick Jonas revealed henna artists, balloon twisters, clowns, about the Kids Party. It’s a time to get some A fourth generation thrift shopper and someone who has lived said happily. “When I was diagnosed with diabetes at 11, my parents to the world that he has type 1 diabetes dur - jugglers, magicians, and palm readers. relief from the seriousness of diabetes and ing a performance by The Jonas Brothers . But watch kids and adults have fun while at the with type 1 diabetes for 15 years, Liz creatively combined her biggest encouraged me to stay positive, and I always have. Now, I apply As Carnival for a Cure settled down in even without a concert this year, the event same time raising funds for the serious work passion with the cause most important to her. As beneficent as that same advice to Cure Thrift Shop.” Manhattan, Long Island’s Kids Party for a Cure didn’t disappoint. of finding a cure,” said Debra. she is bubbly, she donates the store’s net profit to the DRIF. Cure Thrift Shop is located at 111 East 12th Street. If you blasted off. Bigger and better than ever and “It feels like these are people I have known my whole life. Everyone is are not in the New York area, then you can purchase items “With the enthusiasm I saw from this year’s once again led by Co-chairs Debra and John Don’t let your family miss the fun in 2011! To so warm,” she said about the DRI family. “And I am comfortable with at www.CureThriftShop.com. Donations can be made onsite Carnival, I can now say that this great event Carrion and René Checchia , the Party was host receive event updates, register to become a the way the money is spent. The focus really is on research. I am look - or by calling 212-505-7467. has become a fixture in the City and antici - to more than 525 guests at Dave and Buster’s DRInsider at DiabetesResearch.org. ing for a cure – not more treatment options. That is the bottom line.” pated by parents and kids annually,” said in The Mall at The Source in Westbury.

1 2 1. (l-r) Leslie Salmon, Danielle Gregory, and Holly Sherr co-chaired Carnival for a Cure, along with their husbands. LET ME COUNT THE WAYS TO GIVE 2. (l-r) DRI Foundation Long Island Regional Board Chairman Allan L. Pashcow and Chief Operating Officer Deborah Chodrow There are so many different ways to contribute to the Diabetes Research Institute Foundation. Below is a short list of easy ways to give, accepted a check from Kids Party for a Cure Co-chairs René and we have additional ideas posted on our website. Go to: DiabetesResearch.org/WaystoGive Checchia and Debra and John Carrion.

Workplace Giving guide. If your company holds a United Way Paper Snoopys A Gift of Love…A Gift of Hope Many companies encourage employees campaign, you can contribute to the DRI The Paper Snoopy campaign is ideal for re - to support charities through workplace Foundation by utilizing the write-in tailers that want to raise money to benefit campaigns. Gifts are tax deductible and feature. Call 1-800-321-3437 or email the DRI. For a donation of $1 or more, the Fitting for the elegant ladies of the Palm Beach Auxiliary, the luxurious Polo Club of Boca Raton played host can be made through a payroll deduction [email protected] with questions. customer’s name is written on the Paper to the 11th annual A Gift of Love…A Gift of Hope luncheon on February 8 in Florida. Co-chaired by (l-r) Mariana program. Simply select the DRI Foundation Snoopy and displayed in the store. A mini - Sherman and Renee Aronin , the event raised more than $40,000 for the DRI with a lovely day featuring two from your company’s charitable choices Send an e-Card mum of 10 stores is required, and it’s a per - favorite pastimes: shopping and game playing. As 215 Palm Beach women arrived, they browsed a unique and encourage others to do the same. If the Many of you have been making tribute fect fit at supermarkets, pharmacies, boutique, where beautiful jewelry, clothing, handbags, belts and more tempted their desire to acquire. After Foundation is not an option, work with us gifts in honor or memory of loved ones for bookstores, and more. Bonnie and Larry In - enjoying a delicious lunch, the ladies were invited to play Duplicate Bridge, Canasta, Mah Jong and Scrabble. to learn how to get it included. years. Soon, it will be even easier! On our serra , owner of 22 ShopRite supermarkets website, DiabetesResearch.org, we will be in New Jersey, recently ran the campaign in For Combined Federal Campaign (CFC) offering a variety of beautifully-designed stores and raised much needed funds for Brenda Novak Online Auction for Diabetes participants, our number is #11149 . We are e-Cards, representing birthdays, anniver - the DRI. Contact [email protected] if listed under Health 1st America’s Charities . saries, speedy recovery and more. What gift you’re interested in getting your local Breaking $1 million in cumulative proceeds, New York Times bestselling author Brenda Novak held her Sixth Annual The easiest way to find us is the alphabetical could be more meaningful than one made stores involved. Online Auction for Diabetes Research throughout the month of May in honor of her son, Thad , who was diagnosed index at the back of your campaign in tribute of the special people in your life? with type 1 at age 5. Brenda and her husband, Ted , visited the DRI last year, becoming even more dedicated to support - Please check back soon! ing its mission. Bigger and better than ever before, this year’s online auction at BrendaNovak.com offered nearly 2,300 unique items and exciting adventures, raising approximately $286,000 for the DRI. Pictured are Brenda and Thad.

15 | EVENTS Brindisi Coalition for a Cure Don Strock Diabetes Golf Classic

On Saturday, December 6, Louis and Barbara Brindisi welcomed more than 150 guests to the historic Fort Former Miami Dolphins quarterbacks Dan Marino and Don Strock (both pictured) led 150 golfers onto Schuyler Club in Utica, NY. The evening of cocktails and dinner raised nearly $125,000 for the DRI in honor the courses at Miccosukee Golf and Country Club on May 12 for the 27th Annual Don Strock Diabetes Golf of 12-year-old Louis, Jr. , who was diagnosed with type 1 diabetes just last year. After learning about the DRI Classic, presented by Miami Seaquarium. After hitting the links, players enjoyed a cocktail reception and at the Children with Diabetes Conference in Orlando, FL, last summer, the family dedicated themselves to dinner program, during which Strock gave accolades to Tournament Chairman Bruce Fishbein (far right) the cause. They hope to make this fundraiser an annual affair. Pictured are (l-r): DRI Foundation founders and his hard-working committee, which is comprised mainly of members of the produce industry. Pro - Shelly and Barbara Singer with Barbara, Louis, Jr., and Louis Brindisi. ceeds totaled more than $153,000. Also pictured is DRIF National board member Arthur Hertz (far left), chairman and CEO of Wometco Enterprises, Inc., a private company that owns the Miami Seaquarium.

Champions for Charity DREaMS in the City In Manhasset, NY, London Jewelers hosted a glamorous cocktail reception for friends of the DRI Foundation on December 3. Held in conjunction with Americana Manhasset’s Champions for Charity The fifth annual D.R.E.a.M.S. in the City took place on May 6 in the stylish Beaux Arts environs of Capitale in New shopping benefit, the event was co-chaired by Roberta Waller (far left) and Wendy Waller (far right), York City. Chaired by Samantha Shanken Baker and Bonnie Inserra , the event was attended by 350 guests and who are pictured with London Jewelers representatives Randi Udell and Candy Udell (2nd and 3rd raised nearly $500,000. Honorees were Bob DeRoose (left), president and CEO of Kobrand Corporation, and Michel from left), as well as Georgina Chapman (2nd from right), co-founder of the beautiful fashion label Nischan (right), restaurateur, sustainable food advocate, and CEO of Wholesome Wave Foundation. Each of them Marchesa. Chapman, an actress and designer, was on hand to launch a new line of jewelry for Garrard, was presented with the “Dare to Dream” award in recognition of their commitment to eradicating diabetes. the oldest jewelry house in the world. By using the Champions for Charity card, this holiday tradition Among the famous faces seen on the scene were New York Giants players Chris Canty and Adam Koets , celebrity allows shoppers to designate 25% of their purchase totals to benefit the DRI. stylist Phillip Bloch , singer-songwriter Shontelle , and football greats Stan Norfleet and Damien Walker . Alan Kalter of Late Show with David Letterman served as emcee. Special thanks are extended to the vice chairs, the commit - tee and sponsors, including 50-Carat sponsor The Inserra Family , and Platinum sponsors Jane Parker , John Reisman , The Shanken Family Cooking for a Cure Foundation , and Stacy Joy Goodman Memorial Foundation , among others.

On May 7, Chef Jeanine DiMenna once again treated guests of Cooking for a Cure to a gour - met feast at Page One Restaurant in Glen Cove, NY. Led by Co-chairs (l-r) Mary Hall and Delia DRI Walkathon Whitton , a LI Regional Board member and Glen Cove city councilwoman, the event honored Winthrop University Hospital Diabetes Program Director Dr. Siham Accacha (center) along Approximately 150 students from 11 different Broward county schools united in Pembroke Pines, FL, on with special guest Joan Crane. Also shown are DRI Foundation Vice President Tom Karlya and March 13 to support a common cause, while enjoying a beautiful morning at C.B. Smith Park. Celebrating the 30th Anniversary of the annual Seven-Mile Walk/Bike-a-thon, the participants raised another Winthrop University Hospital Certified Diabetes Educator Jean Corrigan (far right). Other $2,000 for the DRI. Charles W. Flanagan High School student Madelyn (Maddy) Johnson (pictured guests of distinction included: Mayor Ralph V. Suozzi , Nassau County Minority Leader Diane right with friends) organized the event for the second year in a row, overseeing the work of not only Yatauro , Judge Richard McCord , and Councilmen Nick DiLeo , Sean Dwyer and Anthony the members of her own National Honor Society (NHS), but also of all the other participating NHS and Jimenez . Senator Carl Marcellino contributed a grant to add to the success of this seventh National Junior Honor Societies in Broward County. Miramar High School student Nicole Didio , who annual dinner. Hall and Whitton are both mothers of children with type 1 diabetes. was the top fundraiser, earned a Nintendo DS. Other participants went home with prizes they won through trivia games and sports competitions. And nearly everyone proudly donned a DRI t-shirt. Crystal Ball Empire Ball At the 12th Annual Crystal Ball, Honorees Michele and Peter Bongiorno (center with daughter Dana, left) gave a moving acceptance speech with a special tribute to their daughter, Lauren (right), who was diag - Led by Chairman Peter DiCapua (right), the Empire Ball took place on December 14 at the Grand Hyatt Hotel nosed with type 1 diabetes 10 years ago. Held at the beautiful Garden City Hotel in Garden City, NY, on in New York. More than 900 guests attended the elegant affair, helping to raise $1 million. Sponsored each May 1, the elegant gala raised more than $500,000. DRI researcher Dr. Norma Sue Kenyon , who also has year by the Real Estate Division of the DRI, the event was highlighted by an appearance by Ron Darling , a daughter with type 1 diabetes, was the recipient of the Gillin Family Humanitarian Award this year. Mets All-Star pitcher and color analyst. The prestigious Empire Ball Award was presented to Gaston Silva Additional awards were given to Roberta & Bruce Waller & Family and the Rowland & Sylvia Schaefer (left), chief operating officer of Vornado Realty Trust. And Michele Medaglia (center), president and CEO of Family Foundation as the Crystal Ball Presenting Sponsor, Joan & Bill Fishlinger for the Future Leadership ACC Construction, received the Camillo Ricordi Humanitarian Award. DiCapua, president of Atco Properties, Foundation, Inc. , and Charlie Rizzo and Bruce Waller for their commitment to the Crystal Ball as co-chairs. was given the first ever Distinguished Service award for his many years of dedication to the DRI.

Diamond Ball Labor of Love Directed by former NFL players (l-r) Henri Crockett , O.J. Santiago and Zach Crockett , the Crockett Foundation joined forces with the Love and Hope Committee, represented by Executive Chairman The 25th Anniversary Labor of Love Golf Tournament was held January 21-23 in Orlando, Sandra Levy (front), to support the DRI with the inaugural Diamond Ball. On the evening of February 2, FL, at Disney’s breathtaking Osprey Ridge Golf Course. Hosted each year by the Building they welcomed celebrities, fellow athletes and philanthropists to South Beach’s Clevelander Hotel. and Construction Trades Department (BCTD) of the AFL-CIO and led by President Mark H. Combining all the glitz and glamour of Miami’s Ocean Drive with the excitement surrounding one Ayers , Labor of Love is an integral part of Project Type Zero. In the past 25 years, the unions of the most anticipated games of the year, Super Bowl XLIV™, this cocktail reception also benefited have donated more than $40 million to the DRI. Pictured are (l-r) DRI Foundation President Broward’s Children Center. Henri has type 1 diabetes and cites the disease as the reason he left the and CEO Robert A. Pearlman , BCTD President Mark H. Ayers , Nancy Smalskas and Drew NFL. The DRIF is eager to partner with the Crockett Foundation again in the future. Varga of Harrah’s Entertainment, and BCTD Secretary/Treasurer Sean McGarvey .

17 | EVENTS Lanie’s Lanes / Cycle for Lanie Sportsmen for Charity

The family and friends of Helaine Shari White gather together year-after-year to support the DRI in The eighth annual Sportsmen for Charity sporting clay event took place on May 14 at Pawling memory of their loved one nicknamed Lanie, who passed away from complications of diabetes a decade Mountain Club in Pawling, NY. Bordered by Appalachian Trail National Park, this club has the ideal ago on May 9, 2000. Lanie’s Lanes, a bowling fundraiser held at AMF East Meadow Bowl, raised $18,000 woodland setting for a day of marksmanship and a good cause. More than 80 discriminating on March 7. The 10th annual event pushed collective proceeds over $200,000. More than 125 people sportsmen attended the event, helping to raise more than $25,000 for the DRI. Pictured is Charles attended, including organizers and family members Rhoda and Don White (left) , Renee and Ron Spiegel Guigno , event chairman, with his family. (Back l-r): Kristin Ferrigno , Ilene Guigno , Charlie Guigno , (right) , and Kim and David McGarvey . Another event, Cycle for Lanie, organized by Hillari and Peter Bortiz , Donna Ferrigno , and Michael Sinodinos . (Front l-r): Joseph Ferrigno and Debbie Sinodinos . was held on May 2 in conjunction with America's largest cycling event, Bike New York’s TD Bank Five Boro Bike Tour. Approximately 40 people rode for Lanie, raising another $13,000 with that effort. Vince Wilfork’s Draft Day Fundraiser Love and Hope For the seventh year, New England Patriots nose tackle Vince Wilfork threw a draft day party at Pinz in In the 36th season of Love and Hope, combined proceeds from the Preview Party and the Love and Hope Ball Milford, MA, on April 22. He and his wife, Bianca , hold this event annually in memory of his father who reached $1 million. Themed Honoring America , the Ball was held at Westin Diplomat Resort & Spa in Hol - passed away from complications of diabetes when Vince was in college. More attendees than ever be - lywood, FL, on February 13. International Chairmen Linda and Barry Gibb were in attendance, showing grat - fore enjoyed the popular event, which raised more than $100,000. These proceeds included a $50,000 itude for this season’s honorees: Grand Humanitarians Roberta and Dr. Harvey Chaplin ; Honorary Chairmen matching gift by the ever generous Wilforks. Jill and Cliff Viner ; Love Honorees Marion and Dr. Donald Golden ; Hope Honorees Lenore Toby-Simmons and Dr. Bernard Simmons ; Preview Party Hostess Isabel May ; Cocktail Reception Hosts Sandy and Senator Paul Steinberg ; Shining Star Francine Lowe ; Gold Star Shirley Harris ; Silver Star Florence Frank ; and Platinum Stars Suzanne and Donald Bezahler . National Chairman Kathy Simkins was also recognized, as were spon - Vintages sors Neiman Marcus, Saks Fifth Avenue, The GEO Group, and Positive ID. At the Thank You Luncheon in April, the annual and coveted Star Award was presented by International Chairman Linda Gibb (left) and Executive Chairman Sandra Levy (right) to Sporting evening wear from across the decades, nearly 250 guests took a trip back in time while enjoy - an astonished Life Chairman Sonja Zuckerman , who has led this dedicated group for decades. ing the premiere Vintages Gala at Wellington’s International Polo Club Palm Beach on February 20. Celebrating many favorites from the past and creating an evening to remember in the future, the unique MichCanSka event featured an antique car show, silent movie classics, a vintage piano lounge, dinner, dancing, auctions, and much more. Prior to Vintages, Chairpersons Terri and Carmine Priore III (pictured with Robert A. Pearlman ) and their hard-working committee held two other events. On November 14, guests arrived Part of Project Type Zero, a fundraising initiative sponsored by the Building and Construction at Breakers West Country Club for “Puttin’ on the Ritz” wearing party clothes from the 1920s and carry - Trades Department of the AFL-CIO, MichCanSka was billed as the “Iditarod of Snowmobiling.” Held ing a gift that would later be used in themed baskets for the silent auction at Vintages. And on Decem - in February, it was the brainchild of Bill Bradfield of Cadillac, MI, a retired sheet metal worker and ber 14, supporters including Golf Pro Michelle McGann participated in the DRI Wellington Golf Classic at Vietnam veteran who has type 2 diabetes. “Snowmobiling for a Diabetes Free Tomorrow,” 90 riders The Wanderers Club. Combined proceeds of these efforts totaled $160,000. crossed North America from Michigan through Canada and into Alaska. Maintaining a distance of 200 miles per day, the group took 20 days to cover 4,000 miles, raising more than $55,000. Walgreens Softball Tournament

Randi Fibus-Caster Pro Am Diabetes Golf Classic On March 27, more than 1,000 South Florida Walgreens employees, along with family and friends, met at Tradewinds Park in Coconut Creek, FL, with softball mitts in-hand. Thirteen Approximately 120 amateur golfers showed their support of the DRI by playing through the rain alongside teams competed for the win, which was taken by Fort Lauderdale South for the second year. professionals such as LPGA’s Michelle McGann (left) at the first-ever Randi Fibus-Caster Pro Am Diabetes Golf DRIF's Tom Karlya (center, front) accepted a check for $10,000 raised through the tournament Classic on Sunday, April 18 at The Polo Club of Boca Raton in Florida. The event, which raised more than $140,000, from Market Vice President Roy Ripak (center, back), Market Pharmacy Director Georgia continued with a cocktail reception, silent auction and dinner, where DRIF’s Robert A. Pearlman (right) thrilled Lephoczky, R.Ph. (left) and other Walgreens representatives. Contributions to this campaign can Chairpersons Ken and Jeanne Fibus and Dr. Howard and Carolyn Leemon , as well as 240 other guests in be made by dropping change into collection canisters bearing the words “Help Cure Diabetes attendance, with a surprise announcement: A room at the DRI will be named after Randi Fibus-Caster (center). Now” on counters in Walgreens stores from Key West all the way up through Martin County. In the Fall, look for university-clad stuffed bears and footballs for sale to benefit DRI. Shell Key West Challenge Young Professionals Committee The beautiful waters surrounding Key West, FL, set the scene for the 2010 Shell Key West Challenge April 22-25. The Young Professionals Committee (YPC) of the DRI Foundation held its inaugural event at The More than 175 Shell Oil executives, employees, wholesalers, and corporate sponsors traveled from 30 states for this Saloon NYC in Manhattan on Thursday, April 22. Chairs Lindsey Inserra (left) and Amanda Viner scavenger hunt of fishing tournaments. The affair is organized annually by Blaylock Oil Company in honor of 10-year- (right) welcomed 75 attendees to an evening of socializing, networking, and learning about how old Matthew Sanchez , who was diagnosed with type 1 diabetes five years ago. The grandson of Hayden Blaylock and to get involved with the YPC. The group is made up of young professionals who either have diabetes the son of Crystal Blaylock-Sanchez and John Sanchez , Matthew is a frequent speaker at DRIF events. The office of or who are personally tied to the disease through family and friends. Their goal is to raise aware - Dr. Luca Inverardi , who has participated in this event for the past four years, was named in Matthew's honor. In that ness about diabetes and to provide funding to the DRI. New members are welcome! For more time, the event has raised $350,000 thanks to the efforts of Blaylock Oil Company of Homestead, FL, and generous information, contact the DRIF’s Northeast regional office at 212-888-2217 or [email protected]. sponsors such as Shell Oil Products US and Motiva Enterprises. Matthew is pictured (left) with his brother, Cameron .

19 | DRI focus Non-Profit Org. US Postage Diabetes Research Institute Foundation PAID National Office Diabetes Research 200 South Park Road Institute Foundation Suite 100 Hollywood, FL 33021

address service requested

For information on the events or to make reservations, please call one of the DRI Foundation offices listed below. CALENDAR Rod Gilbert DRI Golf Classic Pleasures of the Palate Hold’em tournament for poker en - will feature a day on the course, August 9, 2010 / LONG ISLAND October 24, 2010 / FLORIDA thusiasts will feature vintage wines, followed by cocktails and dinner. To be held at Pine Hollow Country Guests will enjoy a four-course meal fine cigars, hors d’oeuvres and Club, this event will feature an paired with wines from around the panoramic views of New York City. Palm Beach Auxiliary Luncheon afternoon of golf followed by an world, plus silent and live auctions, February 2011 - TBD / FLORIDA awards dinner and a silent auction. at this 12th annual dinner to be held Love and Hope Preview Party Now in its 12th year, this delightful at Emeril’s Miami Beach. November 18, 2010 / FLORIDA luncheon will include boutique Phil Peterson’s Key West Poker Run Often referred to as “the heart shopping and a card party at The September 16 – 19, 2010 / FLORIDA Fall Into Fashion of Love and Hope,” this fabulous Polo Club of Boca Raton. Phil Peterson will host his 38th October 28, 2010 / LONG ISLAND dinner reception will officially kick annual motorcycle run, which To be held at Garden City Hotel off the group’s fundraising season Love and Hope Ball starts in Miami and finishes in Key in Garden City, NY, this event will at the Diplomat Country Club February 19, 2011 / FLORIDA West for South Florida’s biggest offer a splendid brunch, silent in Hallandale. To be held at the Westin Diplomat biker party weekend of the year. auction and more. Resort & Spa in Hollywood, this Empire Ball extraordinary gala is certain to Young Society of Love and Stand Up for a Cure December 6, 2010 / NEW YORK delight its guests while commemo - Hope Luncheon November 2010 - TBD / CALIFORNIA New York’s Real Estate Division rating 37 years of success. October 7, 2010 / FLORIDA Comics will bring down the house of the DRI will gather at the Grand The ladies of the Young Society during another hilarious, star- Hyatt Hotel for this elegant, Labor of Love Golf Tournament of Love and Hope will host a studded evening in Los Angeles. black-tie affair. February 24-26, 2011 / FLORIDA luncheon featuring a fashion The Building and Construction show by The Webster at Acqualina All in for a Cure DRI Wellington Golf Classic Trades Department of the AFL-CIO Resort and Spa in Sunny Isles. November 9, 2010 / NEW YORK December 2010 - TBD / FLORIDA will hold its annual golf tournament Tickets are $125 each. To be held at the Grand Havana To be held at The Wanderers Club in at the Buena Vista Palace Hotel & Room, the third annual Texas Wellington, this second annual event Spa and Magnolia Golf Course.

is a publication of the Diabetes Research Institute Foundation. DRI focus Summer 2010 / Volume 37, Issue 2

Marketing & Aimee Siegel-Harris Marc S. Levine Photography The Diabetes Research Institute Foundation supports the Diabetes Research Institute at the University of Miami Leonard M. Miller Communications Dept. Jane Sparrow-Bodenmiller, Karla Mason School of Medicine, whose mission is to develop and rapidly apply the most promising research to treat and cure those now living Lori Weintraub, APR R.N., C.D.E. Eugene Mim/ with diabetes. To obtain additional information or request copies of DRIfocus, please call (800) 321-3437 or e-mail Lauren Schreier Mitra Zehtab, M.D. PatrickMcMullan.com [email protected], or visit DiabetesResearch.org. Natasha Norris Stacy Zolotin Sarah Merians Photography Laurie Cummings and Video Company DIABETES RESEARCH INSTITUTE FOUNDATION Photography Jon Simon Contributors CLIX! Photography Scott Wagar National Office Northeast Regional Office Long Island Regional Office Jeanne Antol Krull DRI / DRIF staff and volunteers Claude Zick 200 South Park Road, Suite 100 381 Park Avenue South, Suite 1118 410 Jericho Turnpike, Suite 201 Gary Kleiman Gary Kane/ Hollywood, FL 33021 New York, NY 10016 Jericho, NY 11753 Kellie Rodriguez , Kanephotography.net Design Phone: (954) 964-4040 Phone: (212) 888-2217 Phone: (516) 822-1700 M.S.N., C.D.E. Vanessa Lam-Mendieta Franz Franc Design Group Inc. Fax: (954) 964-7036 Fax: (212) 888-2219 Fax: (516) 822-3570 Jill Salter of VLM Studios [email protected] [email protected] [email protected]