DEPARTMENT OF JUSTICE DRUG ENFORCEMENT ADMINISTRATION, OFFICE OF DIVERSION CONTROL ARCOS 3 - REPORT 7 UNITED STATES SUMMARY FOR RETAIL DRUG PURCHASES BY GRAMS WT REPORTING PERIOD: 01/01/2011 TO 12/31/2011 Run Date: 01/04/2017

DISCLAIMER: Automated Reports and Consolidated Ordering System (ARCOS) is a data collection system in which manufacturers and distributors report their controlled substances transactions to the Drug Enforcement Administration (DEA). ARCOS provides an acquisition/distribution transactional records of applicable activities to the DEA involving certain controlled substances, in accordance with Title 21, United States Code, Section 827(d)(1), and Title 21, Code of Federal Regulations, Section 1304.33. This information is collected and compiled by DEA in accordance with law for determining quota, distribution trends, internal audits, and other analyses.

Recipients should be aware, prior to use, analysis, studies, or publication of ARCOS data, the information contained in ARCOS generated reports are complete and accurate as to what was provided by DEA registrants to ARCOS in accordance with reporting requirements. This information is susceptible to future updates and corrections, without notice, as new information is obtained. DEA assumes no liability for analysis, conclusions or policy decisions of third parties based on internal interpretation of provided data. ARCOS 3 - REPORT 7 UNITED STATES SUMMARY FOR RETAIL DRUG PURCHASES BY GRAMS WT Run Date: 01/04/2017 REPORTING PERIOD: 01/01/2011 TO 12/31/2011

ENTIRE UNITED STATES BUSINESS ACTIVITY: A - PHARMACIES DRUG NAME DRUG CODE BUYERS TOTAL GRAMS AVG GRAMS AMPHETAMINE 1100 60,207 12,559,550.11 208.61 DL-METHAMPHETAMINE RACEMIC BASE 1105B 1,841 6,655.84 3.62 D-METHAMPHETAMINE 1105D 1,182 4,956.17 4.19 LISDEXAMFETAMINE 1205 55,546 6,775,223.81 121.98 METHYLPHENIDATE (DL;D;L;ISOMERS) 1724 60,736 18,258,116.80 300.61 GAMMA HYDROXYBUTYRIC ACID(FDA APPROVED-CSA III) 2012 1 17,577,800.06 17577800.06 AMOBARBITAL (SCHEDULE 2) 2125 3 26.89 8.96 BUTALBITAL 2165 43,194 2,385,233 55.22 PENTOBARBITAL (SCHEDULE 2) 2270 136 10,129.98 74.49 SECOBARBITAL (SCHEDULE 2) 2315 712 18,905.08 26.55 ZOLPIDEM 2783 110 2,555.68 23.23 LORAZEPAM 2885 6 6.5 1.08 NABILONE 7379 270 53.54 0.2 COCAINE 9041 2 0 0 COCAINE 9041L 454 3,372.82 7.43 CODEINE 9050 63,518 15,363,026.79 241.87 BUPRENORPHINE 9064 55,070 1,639,626.44 29.77 DIHYDROCODEINE 9120 10,694 73,729.39 6.89 OXYCODONE 9143 62,121 60,421,564.95 972.64 HYDROMORPHONE 9150 55,457 1,317,972.70 23.77 HYDROCODONE 9193 64,838 45,626,503.95 703.7 LEVORPHANOL 9220L 292 569.06 1.95 MEPERIDINE (PETHIDINE) 9230 34,377 1,376,321.81 40.04 METHADONE 9250B 52,484 5,905,473.92 112.52 MORPHINE 9300 59,433 20,588,438.24 346.41 OPIUM POWDERED 9639 4,119 14,733.12 3.58 OXYMORPHONE 9652 39,889 2,224,002.23 55.75 NOROXYMORPHONE 9668 2 2.31 1.16 ALFENTANIL 9737 75 20.94 0.28 REMIFENTANIL 9739 86 12.52 0.15 SUFENTANIL BASE 9740 148 66.67 0.45 CARFENTANIL 9743 1 0.12 0.12 TAPENTADOL 9780 45,227 5,086,675.41 112.47 FENTANYL BASE 9801 59,740 434,608.07 7.27 ARCOS 3 - REPORT 7 UNITED STATES SUMMARY FOR RETAIL DRUG PURCHASES BY GRAMS WT Run Date: 01/04/2017 REPORTING PERIOD: 01/01/2011 TO 12/31/2011

ENTIRE UNITED STATES BUSINESS ACTIVITY: B - HOSPITALS DRUG NAME DRUG CODE BUYERS TOTAL GRAMS AVG GRAMS AMPHETAMINE 1100 3,551 326,163.79 91.85 DL-METHAMPHETAMINE RACEMIC BASE 1105B 32 59.07 1.85 D-METHAMPHETAMINE 1105D 46 259.58 5.64 LISDEXAMFETAMINE 1205 1,394 70,100.58 50.29 METHYLPHENIDATE (DL;D;L;ISOMERS) 1724 5,426 658,200.57 121.3 AMOBARBITAL (SCHEDULE 2) 2125 211 1,212.62 5.75 BUTALBITAL 2165 885 18,445 20.84 PENTOBARBITAL (SCHEDULE 2) 2270 818 287,006.69 350.86 SECOBARBITAL (SCHEDULE 2) 2315 24 485.22 20.22 LORAZEPAM 2885 1 1 1 NABILONE 7379 11 2.35 0.21 5-METHOXY-N,N-DIISOPROPYLTRYPTAMINE(5-MEO-DIPT) 7439 1 0.06 0.06 PHENCYCLIDINE (PCP) 7471 1 0.22 0.22 COCAINE 9041 72 0 0 COCAINE 9041L 4,051 36,756.90 9.07 CODEINE 9050 7,882 1,334,539.85 169.31 BUPRENORPHINE 9064 3,624 56,641.18 15.63 DIHYDROCODEINE 9120 121 431.18 3.56 OXYCODONE 9143 8,377 2,926,747.04 349.38 HYDROMORPHONE 9150 7,785 288,799.81 37.1 HYDROCODONE 9193 9,111 1,857,609.70 203.89 LEVORPHANOL 9220L 15 8.59 0.57 MEPERIDINE (PETHIDINE) 9230 7,726 592,988.67 76.75 METHADONE 9250B 5,926 570,619.08 96.29 MORPHINE 9300 9,263 3,117,986.85 336.61 OPIUM TINCTURE (LAUDANUM) 9630 16 432.1 27.01 OPIUM POWDERED 9639 3,526 21,043.08 5.97 OXYMORPHONE 9652 901 18,372.56 20.39 ALFENTANIL 9737 1,085 430.61 0.4 REMIFENTANIL 9739 1,859 1,044.48 0.56 SUFENTANIL BASE 9740 2,293 68.06 0.03 TAPENTADOL 9780 1,512 64,202.22 42.46 FENTANYL BASE 9801 9,525 111,677.10 11.72 ARCOS 3 - REPORT 7 UNITED STATES SUMMARY FOR RETAIL DRUG PURCHASES BY GRAMS WT Run Date: 01/04/2017 REPORTING PERIOD: 01/01/2011 TO 12/31/2011

ENTIRE UNITED STATES BUSINESS ACTIVITY: C - PRACTITIONERS DRUG NAME DRUG CODE BUYERS TOTAL GRAMS AVG GRAMS AMPHETAMINE 1100 133 4,134.24 31.08 D-METHAMPHETAMINE 1105D 2 8.03 4.02 LISDEXAMFETAMINE 1205 110 2,839.60 25.81 PHENDIMETRAZINE 1615 1 4.71 4.71 METHYLPHENIDATE (DL;D;L;ISOMERS) 1724 136 6,857.29 50.42 BUTALBITAL 2165 53 1,618 30.53 PENTOBARBITAL (SCHEDULE 2) 2270 5,971 5,655,251.93 947.12 PHENCYCLIDINE (PCP) 7471 2 0.91 0.46 COCAINE 9041 104 0 0 COCAINE 9041L 705 3,688.36 5.23 NORCOCAINE 9046 1 0.03 0.03 CODEINE 9050 3,683 105,372.01 28.61 BUPRENORPHINE 9064 16,675 4,970.80 0.3 DIHYDROCODEINE 9120 4,691 2,626.97 0.56 OXYCODONE 9143 2,228 158,777.97 71.26 HYDROMORPHONE 9150 7,961 7,532.22 0.95 HYDROCODONE 9193 36,261 405,331.34 11.18 LEVORPHANOL 9220L 1 0.06 0.06 MEPERIDINE (PETHIDINE) 9230 6,520 80,366.84 12.33 METHADONE 9250B 200 7,973.20 39.87 MORPHINE 9300 10,862 60,723.55 5.59 OPIUM 9600 1 2 2 OPIUM POWDERED 9639 95 223.2 2.35 OXYMORPHONE 9652 325 3,710.01 11.42 NOROXYMORPHONE 9668 177 525.36 2.97 ALFENTANIL 9737 327 80.45 0.25 REMIFENTANIL 9739 384 35.1 0.09 SUFENTANIL BASE 9740 120 11.64 0.1 CARFENTANIL 9743 1 0.06 0.06 TAPENTADOL 9780 100 4,572.06 45.72 FENTANYL BASE 9801 14,833 2,513.95 0.17

ENTIRE UNITED STATES BUSINESS ACTIVITY: D - TEACHING INSTITUTIONS DRUG NAME DRUG CODE BUYERS TOTAL GRAMS AVG GRAMS AMPHETAMINE 1100 2 268.12 134.06 D-METHAMPHETAMINE 1105D 5 5.42 1.08 LISDEXAMFETAMINE 1205 1 125.45 125.45 ARCOS 3 - REPORT 7 UNITED STATES SUMMARY FOR RETAIL DRUG PURCHASES BY GRAMS WT Run Date: 01/04/2017 REPORTING PERIOD: 01/01/2011 TO 12/31/2011

METHYLPHENIDATE (DL;D;L;ISOMERS) 1724 1 185.56 185.56 PENTOBARBITAL (SCHEDULE 2) 2270 21 41,856.50 1,993.17 PHENCYCLIDINE (PCP) 7471 1 0.22 0.22 COCAINE 9041L 1 0.89 0.89 CODEINE 9050 7 333.07 47.58 BUPRENORPHINE 9064 86 10.1 0.12 OXYCODONE 9143 1 8.25 8.25 HYDROMORPHONE 9150 16 43.98 2.75 HYDROCODONE 9193 17 164.16 9.66 MEPERIDINE (PETHIDINE) 9230 7 26.15 3.74 METHADONE 9250B 4 100.71 25.18 MORPHINE 9300 23 176.49 7.67 OXYMORPHONE 9652 5 2.03 0.41 REMIFENTANIL 9739 6 0.2 0.03 TAPENTADOL 9780 1 35 35 FENTANYL BASE 9801 25 19.34 0.77

ENTIRE UNITED STATES BUSINESS ACTIVITY: M - MID-LEVEL PRACTITIONERS DRUG NAME DRUG CODE BUYERS TOTAL GRAMS AVG GRAMS AMPHETAMINE 1100 3 235.92 78.64 LISDEXAMFETAMINE 1205 2 18.05 9.03 METHYLPHENIDATE (DL;D;L;ISOMERS) 1724 5 28.1 5.62 BUTALBITAL 2165 3 70 23.33 PENTOBARBITAL (SCHEDULE 2) 2270 908 2,298,227.91 2,531.09 CODEINE 9050 73 1,981.31 27.14 BUPRENORPHINE 9064 26 1.02 0.04 DIHYDROCODEINE 9120 684 306.24 0.45 OXYCODONE 9143 14 420.17 30.01 HYDROMORPHONE 9150 69 56.71 0.82 HYDROCODONE 9193 2,326 5,399.76 2.32 MEPERIDINE (PETHIDINE) 9230 72 217.44 3.02 METHADONE 9250B 1 33.99 33.99 MORPHINE 9300 642 564.68 0.88 OXYMORPHONE 9652 1 5.35 5.35 NOROXYMORPHONE 9668 2 9.26 4.63 ALFENTANIL 9737 1 0.01 0.01 TAPENTADOL 9780 1 10 10 FENTANYL BASE 9801 487 10 0.02 ARCOS 3 - REPORT 7 UNITED STATES SUMMARY FOR RETAIL DRUG PURCHASES BY GRAMS WT Run Date: 01/04/2017 REPORTING PERIOD: 01/01/2011 TO 12/31/2011

ENTIRE UNITED STATES BUSINESS ACTIVITY: N-U NARCOTIC TREATMENT PROGRAMS DRUG NAME DRUG CODE BUYERS TOTAL GRAMS AVG GRAMS METHYLPHENIDATE (DL;D;L;ISOMERS) 1724 1 0.86 0.86 BUPRENORPHINE 9064 222 8,267.19 37.24 DIHYDROCODEINE 9120 1 0.47 0.47 OXYCODONE 9143 3 9.41 3.14 HYDROMORPHONE 9150 1 0.89 0.89 METHADONE 9250B 1,165 8,829,742.50 7,579.18 MORPHINE 9300 3 18.95 6.32