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Scarica in Formato CONSORZIO INTERUNIVERSITARIO Istituto Nazionale Biostrutture e Biosistemi V CONVEGNO NAZIONALE CATANIA, 3-5 OTTOBRE 2002 AULA MAGNA – DIPARTIMENTO DI MATEMATICA E INFORMATICA UNIVERSITÀ DEGLI STUDI DI CATANIA VIALE ANDREA DORIA, 6 CATANIA 1 V CONVEGNO NAZIONALE I.N.B.B. Comitato Scientifico Prof. Damiano Gustavo Mita Prof. Antonio Cambria Prof. Carlo Di Benedetta Prof. Anna Maria Giuffrida Stella Prof. Paolo Madeddu Comitato Organizzatore Prof. Damiano Gustavo Mita Dott. Paolo Occhialini Sig.ra Lucia Occhioni Segreteria Organizzativa I.N.B.B. Viale delle Medaglie D’Oro, 305 00136 Roma Tel 06/35340153 Fax. 06/35451637 [email protected] 2 ORGANI DEL CONSORZIO I.N.B.B. Presidente INBB Prof. Damiano Gustavo Mita Direttore INBB Dott. Paolo Occhialini Consiglio Direttivo INBB Giunta Esecutiva INBB Prof. Ivano Bertini Prof. Claudio Cobelli Prof. Maurizio Brunori Prof. Ferruccio Fazio Prof. Antonio Cambria Prof. Damiano Gustavo Mita Prof. Alberto Cangiano Prof. Claudio Nicolini Prof.ssa Rita Casadio Dott. Paolo Occhialini Prof. Claudio Cobelli Prof. Riccardo Pierantoni Prof. Carlo Di Benedetta Prof. Vittorio Tomasi Prof. Ferruccio Fazio Prof. Giuseppe Rotilio Prof. Carlo Frediani Prof. Leonardo Gaspa Prof. Gaetano Irace Laboratorio Nazionale Prof. Giulio Magni Direttore Prof. Francesco Mauro Prof. Leonardo Gaspa Prof. Damiano Gustavo Mita Prof. Claudio Nicolini Resp. Sez. Tec. Biomediche Dott. Paolo Occhialini e Terapia Genica Prof. Riccardo Pierantoni Prof. Paolo Madeddu Prof. Adelio Rigo Prof. Giuseppe Rotilio Resp. Sez. Biologia Cellulare Prof. Vittorio Tomasi Prof. Carlo Ventura Prof. Paolo Viglino Collegio dei Revisori Dott.ssa Liana Meucci Dott.ssa Daniela Procaccia Dott.ssa Marina Tesauro 3 INDICE Programma V Convegno Nazionale Pag. 5 Relazione introduttiva del Presidente Prof. D.G. Mita Pag. 7 Abstract comunicazioni Pag. 11 Abstract poster Pag. 55 Unità di Ricerca INBB Pag. 115 Informazioni in merito al Consorzio, come: Elenco Aderenti, Statuto e Laboratorio Nazionale possono essere reperite nel sito www.inbb.it 4 V CONVEGNO NAZIONALE I.N.B.B. Programma GIOVEDÌ 3 OTTOBRE 2002 h. 14,30 Registrazione dei partecipanti h. 16,00 Apertura dei lavori: PROF. FERDINANDO LATTERI (Rettore Università degli Studi di Catania) PROF. UMBERTO SCAPAGNINI (Sindaco della Città di Catania) ON.LE NELLO MUSUMECI (Presidente Prov. Catania) Saluto dei Presidi: PROF. RENATO PUCCI (Facoltà Scienze MFN) PROF. GIUSEPPE RONSISVALLE (Facoltà Farmacia) PROF. AGOSTINO SERRA (Facoltà Medicina e Chirurgia) h. 16,45 Introduzione: PROF. DAMIANO GUSTAVO MITA (Presidente I.N.B.B.) h. 17,30 1° Tavola Rotonda “Priorità del Sistema Ricerca Nazionale: obiettivi e risorse finanziarie del PNR” Partecipano: PROF. GIANNI FABRI (Comm. FIRB MIUR) PROF. VINCENZO LUNGAGNANI (Rapp. Assobiotech) PROF. MAURO MAGNANI (Pres. Consorzio Biotecnologie) PROF. CLAUDIO NICOLINI (Pres. Polo Naz. Bioelettronica) PROF. UMBERTO SCAPAGNINI (Europarlamentare) DOTT. SALVO COFFA (ST Microelectronics) DOTT. PAOLO SASSETTI (Esperto di Venture Capital) Conclude: ON. STEFANO CALDORO (Sottosegretario MIUR) VENERDÌ 4 OTTOBRE 2002 h. 09,15 Sessione “Biosistemi e Bioregolazioni” Chairman: PROF.SSA MARIA SVELTO Comunicazioni scientifiche 1. Prof. Fabio Benfenati “Interazioni proteina-proteina coinvolte nel controllo del rilascio di neurotrasmettitore” 2. Prof. Antonio Contestabile “Role of the trascription factor, creb, in the survival promoted by activation of NMDA receptor in cerebellar granule cells and by nitric oxide in the same neurons and in neuroblastoma cells.” 3. Prof. Egidio D’Angelo 4. Prof. Antonio Frigeri “Interferenza dell’RNA: un nuovo metodo per lo studio del ruolo dell’acquaporina-4 negli astrociti di mammifero e nell’edema cerebrale” 5. Dott.ssa Annalisa Nicotra “Clonaggio ed analisi dell’espressione della CX39, un nuovo membro della famiglia multigenica delle connessine” h. 11,30 Sessione “Biotecnologie” Chairman e PROF. MARIO DE ROSA Comunicazioni scientifiche 1. Prof.ssa Donatella Barra “An amphibian antimicrobial peptide expressed in nicotiana tabacum confers resistance against bacteria and fungi” 2. Prof.ssa Marilena Cipollaro “Riparo enzimatico e ‘real time’ per lo studio del DNA antico” 3. Prof. Marco Mascini “DNA Biosensors for enviromental monitoring” 4. Prof. Mosé Rossi “Recenti progressi sulla biologia molecolare degli ipertermofili” h. 15,00 Sessione “Neuroscienze” Chairman: PROF. PIERGIORGIO STRATA Comunicazioni scientifiche 1. Prof. Piero Paolo Battaglini “Dynamics of the fronto-parietal network for reaching movements in humans : an EEG approach” 2. Prof. Pietro Enrico Di Prampero “La massima potenza muscolare “esplosiva” degli arti inferiori di astronautici dopo volo spaziale prolungato” 3. Prof. Massimo Matelli “Trasformazioni sensori-motorie nei primati: basi anatomiche” 5 4. Prof. Vincenzo Perciavalle “Rappresentazione neurale asimmetrica della posizione dell’arto anteriore nella corteccia paleocerebellare e nel nucleo interposto del ratto” h. 17,00 2° Tavola Rotonda “La valutazione nel sistema università-ricerca del Paese”” Partecipano: PROF. CESARE BALDUINI (Comm. Garanti PRIN) PROF. CARLO CALANDRA (Comm. Naz. Valutazione) PROF. ENRICO RIZZARELLI (Comm. Naz. Riforma Univ.) PROF. ARMIDO RUBINO (Presid. Comm. Garanti PRIN) PROF. PIERGIORGIO STRATA (Univ. Torino) h. 18,30 Chiusura dei lavori della giornata SABATO 5 OTTOBRE 2002 h. 9,15 Sessione “Biomeolecole” Chairman: PROF. ENRICO RIZZARELLI Comunicazioni scientifiche 1. Prof. Umberto Benatti “Gli acidi peptidil nucleici modificati come potenziali farmaci antinfiammatori” 2. Prof.ssa Maria Rosa Ciriolo “Modulazione dello stato redox intracellulare ed induzione della morte cellulare programmata da parte del glutatione disolfuro” 3. Prof. Lorenzo Pinna “Enzimologia molecolare della protein chinasi CK2: un esempio di stachanovismo catalitico” 4. Prof. Pietro Pucci “Strategie di proteomica per l’analisi conformazionale di proteine” h. 11,15 Sessione “Biostrumentazione e Bioelettronica” Chairman: PROF. CLAUDIO NICOLINI Comunicazioni scientifiche 1. Prof. Ermanno Di Zitti “Fabbricazione di strutture nanoelettroniche medianti superreticoli di nanoparticelle di oro tiolate” 2. Prof. Luigi Fortuna “ Non linear circuits for the analysis of DNA microarrays” 3. Prof. Carmelina Ruggiero “Nanobioscience: foundation and applications” 4. Prof. Bruno Samorì “Stretching single molecules with the scanning force microscope” h. 15,00 Sessione “Cellule.” Chairman: PROF. EDON MELLONI – PROF. CESARE BALDUINI Comunicazioni scientifiche 1. Prof. Giovanni Antonini “Attività citoprotettiva della ovotransferrina” 2. Prof. Bruno Giardina “Ciclo di ossigenazione-desossigenazione dell’Hb e modulazione metabolica dell’eritrocita: studi funzionali e computazionali” 3. Prof. Giorgio Lenaz “The mitochondrial production of oxigen radical species and the role of coenzyme Q as an antioxidant” 4. Prof. Giulio Magni “NMN Adenylyltransferase: a key enzyme in nad homeostasis” h. 17,00 Sessione “Unità Funzionali Biologiche Supramolecolari” Chairman: PROF.SSA RITA CASADIO Comunicazioni scientifiche 1. Dott.ssa Maria Luisa Di Paolo “Fattori fisici che modulano la funzione delle ammino ossidasi” 2. Dott. Piero Fariselli “Interactomica in silicio: predizione di interazioni tra proteine in etero-complessi con reti neurali” 3. Prof. Neri Niccolai “Una nuova dimensione della biologia strutturale: studi dell’accessibilità delle superfici proteiche” 4. Prof. Isidoro Pepe “Energetica della fototrasduzione: attività miocinasica nei dischi dei bastoncelli della retina” h. 19,00 Chiusura del Convegno 6 RELAZIONE INTRODUTTIVA Prof. Damiano Gustavo Mita Il mondo accademico e quello della ricerca del nostro Paese vivono ormai da anni in acque particolarmente agitate per l’adozione di scelte politiche con scarsa partecipazione e condivisione collettiva degli attori interessati, tutte in un contesto di costante e progressiva diminuzione delle risorse finanziarie. Ormai siamo notoriamente al di sotto dell’1% del PIL di risorse complessive per R&S, quando nel ’93 eravamo all’1,3%, inutile tentare paragoni con quanto investito in R&S dagli altri paesi industrialmente avanzati: ne usciremmo profondamente mortificati. Con puntuale frequenza trapelano notizie, spesso contrastanti, di nuove riforme degli studi universitari e di riorganizzazione dell’attività degli Enti di Ricerca. La comunità scientifico-accademica appare spesso frastornata e poco reattiva, incapace di determinare gli eventi politico-istituzionali che ne influiscono così pesantemente l’attività. La tavola rotonda prevista in questa giornata inaugurale del V Convegno Nazionale discuterà della situazione odierna in relazione alle priorità dettate dalle recenti Linee guida per la politica scientifica e tecnologica del Governo (deliberate dal CIPE il 19/4 u.s.) e dalle relative risorse finanziarie previste dalla approvanda Legge Finanziaria del 2003. Tali linee guida prevedono che l’azione del Governo si sviluppi su 5 assi strategici: 1) sostegno alla Ricerca di Base; 2) supporto alla ricerca su tecnologie chiave a carattere multisettoriale; 3) potenziamento delle attività di ricerca industriale al fine di aumentare la capacità del sistema produttivo italiano nel trasformare le nuove conoscenze in maggior valore aggiunto; 4) promozione delle capacità di innovazione nei processi e nei prodotti da parte delle PMI valorizzando sinergie a livello territoriali; 5) promozione del sistema di rete delle grandi infrastrutture e dei processi di internazionalizzazione dell’attività di ricerca. Per questi obiettivi il Governo,
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