March 6, 2018 u vol. 115 u no. 10

From the Cover

E2284 Climate change and butterfly hybridization E2264 Emerging alien species source pools 2329 NIH funding and drug development 2335 Crop production and energy use 2449 Neutrophil defense against bacterial spread

Contents

THIS WEEK IN PNAS 2259 In This Issue Cover image: Pictured are tiger swallowtail butterfly larvae. Sean F. Ryan et al. found that the hybrid breeding LETTERS (ONLINE ONLY) zone of eastern (Papilio glaucus) and E2149 Heritability of trust and distrust remains unknown Canadian (Papilio canadensis) tiger Brent Goldfarb, Andrew A. King, and Timothy S. Simcoe swallowtail butterflies has shifted 40 km northward since 1980 in response to E2151 Reply to Goldfarb et al.: On the heritability and socialization of trust climate warming, and that the rate and and distrust shape of future hybrid zone movement Martin Reimann, Oliver Schilke, Ryne Estabrook, and Karen S. Cook are likely to be highly variable. Variation E2153 Diet-induced mating preference in Drosophila in future hybrid zone movement may Eugene Rosenberg, Ilana Zilber-Rosenberg, Gil Sharon, and Daniel Segal have implications for butterfly evolution E2154 Reply to Rosenberg et al.: Diet, gut bacteria, and assortative mating in and conservation. See the article by Drosophila melanogaster Ryan et al. on pages E2284–E2291. Philip T. Leftwich, Naomi V. E. Clarke, Matthew I. Hutchings, and Tracey Chapman Image courtesy of Sean F. Ryan.

NEWS FEATURE—An in-depth look at trending science issues 2260 Can predators have a big impact on carbon emissions calculations? Leslie Willoughby

PROFILE 2264 Profile of Michael Strand Jennifer Viegas See Inaugural Article on page 457 in issue 3 of volume 115

COMMENTARIES 2267 Race to the native state Robert B. Best See companion article on page 1998 in issue 9 of volume 115 2270 New sources for the emergence of new invaders Edwin D. Grosholz See companion article on page E2264 2272 Neutrophils in hot pursuit of MRSA in the lymph nodes Lloyd S. Miller and Scott I. Simon See companion article on page 2449

Free online through the PNAS open access option. PNAS u March 6, 2018 u vol. 115 u no. 10 u iii–viii Downloaded by guest on September 25, 2021 ENVIRONMENTAL SCIENCES PNAS PLUS 2311 Unexpected transformation of dissolved phenols to 2275 Significance Statements toxic dicarbonyls by hydroxyl radicals and UV light Brief statements written by the authors about the significance of their Carsten Prasse, Breanna Ford, Daniel K. Nomura, papers. and David L. Sedlak

PHYSICAL SCIENCES PHYSICS 2317 From global scaling to the dynamics of APPLIED MATHEMATICS individual cities E2156 Fast flow-based algorithm for creating Jules Depersin and Marc Barthelemy density-equalizing map projections Michael T. Gastner, Vivien Seguy, and Pratyush More STATISTICS 2282 Variational structure of Luttinger–Ward formalism E2175 Prospective forecasts of annual dengue hemorrhagic and bold diagrammatic expansion for Euclidean fever incidence in Thailand, 2010–2014 lattice field theory Stephen A. Lauer, Krzysztof Sakrejda, Evan L. Ray, Lindsay T. Lin Lin and Michael Lindsey Keegan, Qifang Bi, Paphanij Suangtho, Soawapak Hinjoy, Sopon Iamsirithaworn, Suthanun Suthachana, Yongjua APPLIED PHYSICAL SCIENCES Laosiritaworn, Derek A.T. Cummings, Justin Lessler, 2287 Doubly hybrid density functionals that correctly and Nicholas G. Reich describe both density and energy for atoms Neil Qiang Su, Zhenyu Zhu, and Xin Xu 2293 Three-dimensional virtual histology enabled through SOCIAL SCIENCES cytoplasm-specific X-ray stain for microscopic and ANTHROPOLOGY nanoscopic computed tomography Madleen Busse, Mark Mu¨ller, Melanie A. Kimm, Simone Ferstl, 2341 Origins and genetic legacies of the Caribbean Taino Sebastian Allner, Klaus Achterhold, Julia Herzen, Hannes Schroeder, Martin Sikora, Shyam Gopalakrishnan, and Franz Pfeiffer Lara M. Cassidy, Pierpaolo Maisano Delser, Marcela Sandoval Velasco, Joshua G. Schraiber, Simon Rasmussen, Julian R. Homburger, Marı´aC.A´vila-Arcos, Morten E. Allentoft, BIOPHYSICS AND COMPUTATIONAL BIOLOGY J. Vı´ctor Moreno-Mayar, Gabriel Renaud, Alberto E2165 Mitotic waves in the early embryogenesis of Go´mez-Carballa, Jason E. Laffoon, Rachel J. A. Hopkins, Drosophila: Bistability traded for speed Thomas F. G. Higham, Robert S. Carr, William C. Schaffer, Massimo Vergassola, Victoria E. Deneke, and Stefano Di Talia Jane S. Day, Menno Hoogland, Antonio Salas, Carlos D. Bustamante, Rasmus Nielsen, Daniel G. Bradley, Corinne L. E2419 Structure-based discovery of selective positive Hofman, and Eske Willerslev allosteric modulators of antagonists for the M2 muscarinic acetylcholine receptor Magdalena Korczynska, Mary J. Clark, Celine Valant, Jun Xu, PSYCHOLOGICAL AND COGNITIVE SCIENCES Ee Von Moo, Sabine Albold, Dahlia R. Weiss, Hayarpi 2323 Algorithms in the historical emergence of Torosyan, Weijiao Huang, Andrew C. Kruse, Brent R. Lyda, word senses Lauren T. May, Jo-Anne Baltos, Patrick M. Sexton, Brian K. Christian Ramiro, Mahesh Srinivasan, Barbara C. Malt, Kobilka, Arthur Christopoulos, Brian K. Shoichet, and Yang Xu and Roger K. Sunahara 2502 Within- and across-trial dynamics of human EEG reveal CHEMISTRY cooperative interplay between reinforcement E2193 Entropy drives selective fluorine recognition in learning and working memory the fluoroacetyl–CoA thioesterase from Anne G. E. Collins and Michael J. Frank Streptomyces cattleya Amy M. Weeks, Ningkun Wang, Jeffrey G. Pelton, SOCIAL SCIENCES and Michelle C. Y. Chang 2329 Contribution of NIH funding to new drug 2299 Optically functional isoxanthopterin crystals in the approvals 2010–2016 mirrored eyes of decapod crustaceans Ekaterina Galkina Cleary, Jennifer M. Beierlein, Navleen Surjit Benjamin A. Palmer, Anna Hirsch, Vlad Brumfeld, Eliahu D. Khanuja, Laura M. McNamee, and Fred D. Ledley Aflalo, Iddo Pinkas, Amir Sagi, Shaked Rosenne, Dan Oron, Leslie Leiserowitz, Leeor Kronik, Steve Weiner, and Lia Addadi SUSTAINABILITY SCIENCE 2335 Crop intensification, land use, and on-farm EARTH, ATMOSPHERIC, AND PLANETARY SCIENCES energy-use efficiency during the worldwide E2274 The timescale of early land plant evolution spread of the green revolution Jennifer L. Morris, Mark N. Puttick, James W. Clark, Dianne Pedro Pellegrini and Roberto J. Ferna´ndez Edwards, Paul Kenrick, Silvia Pressel, Charles H. Wellman, Ziheng Yang, Harald Schneider, and Philip C. J. Donoghue 2305 Rainfall statistics, stationarity, and climate change BIOLOGICAL SCIENCES Fubao Sun, Michael L. Roderick, and Graham D. Farquhar AGRICULTURAL SCIENCES ENGINEERING 2335 Crop intensification, land use, and on-farm 2526 Metabolic division of labor in microbial systems energy-use efficiency during the worldwide Ryan Tsoi, Feilun Wu, Carolyn Zhang, Sharon Bewick, David spread of the green revolution Karig, and Lingchong You Pedro Pellegrini and Roberto J. Ferna´ndez

iv u www.pnas.org Contents Downloaded by guest on September 25, 2021 ANTHROPOLOGY BIOPHYSICS AND COMPUTATIONAL BIOLOGY 2341 Origins and genetic legacies of the Caribbean Taino E2220 Porin self-association enables cell-to-cell contact in Hannes Schroeder, Martin Sikora, Shyam Gopalakrishnan, Providencia stuartii floating communities Lara M. Cassidy, Pierpaolo Maisano Delser, Marcela Sandoval Mariam El-Khatib, Chady Nasrallah, Julie Lopes, Que-Tien Velasco, Joshua G. Schraiber, Simon Rasmussen, Julian R. Tran, Guillaume Tetreau, Hind Basbous, Daphna Fenel, Benoit ´ Homburger, Marı´aC.Avila-Arcos, Morten E. Allentoft, Gallet, Mathilde Lethier, Jean-Michel Bolla, Jean-Marie Page`s, J. Vı´ctor Moreno-Mayar, Gabriel Renaud, Alberto Michel Vivaudou, Martin Weik, Mathias Winterhalter, Go´mez-Carballa, Jason E. Laffoon, Rachel J. A. Hopkins, and Jacques-Philippe Colletier Thomas F. G. Higham, Robert S. Carr, William C. Schaffer, Jane S. Day, Menno Hoogland, Antonio Salas, Carlos D. E2229 Tracking the route of molecular oxygen in O2-tolerant Bustamante, Rasmus Nielsen, Daniel G. Bradley, Corinne L. membrane-bound [NiFe] hydrogenase Hofman, and Eske Willerslev Jacqueline Kalms, Andrea Schmidt, Stefan Frielingsdorf, Tillmann Utesch, Guillaume Gotthard, David von Stetten, Peter van der Linden, Antoine Royant, Maria Andrea Mroginski, APPLIED BIOLOGICAL SCIENCES Philippe Carpentier, Oliver Lenz, and Patrick Scheerer E2183 OligoMiner provides a rapid, flexible environment for the design of genome-scale oligonucleotide in situ 2377 Structure of full-length human TRPM4 Jingjing Duan, Zongli Li, Jian Li, Ana Santa-Cruz, Silvia hybridization probes Sanchez-Martinez, Jin Zhang, and David E. Clapham Brian J. Beliveau, Jocelyn Y. Kishi, Guy Nir, Hiroshi M. Sasaki, Sinem K. Saka, Son C. Nguyen, Chao-ting Wu, and Peng Yin 2383 Gi- and Gs-coupled GPCRs show different modes of G-protein binding 2347 Synthetic addiction extends the productive life time Ned Van Eps, Christian Altenbach, Lydia N. Caro, Naomi R. of engineered Escherichia coli populations Latorraca, Scott A. Hollingsworth, Ron O. Dror, Oliver P. Ernst, Peter Rugbjerg, Kira Sarup-Lytzen, Mariann Nagy, and Wayne L. Hubbell and Morten Otto Alexander Sommer 2389 Molecular basis for diversification of yeast prion 2353 Revealing nascent proteomics in signaling pathways strain conformation and cell differentiation Yumiko Ohhashi, Yoshiki Yamaguchi, Hiroshi Kurahashi, Yuji O. Craig M. Forester, Qian Zhao, Nancy J. Phillips, Anatoly Kamatari, Shinju Sugiyama, Boran Uluca, Timo Piechatzek, Urisman, Robert J. Chalkley, Juan A. Oses-Prieto, Li Zhang, Yusuke Komi, Toshinobu Shida, Henrik Mu¨ller, Shinya Davide Ruggero, and Alma L. Burlingame Hanashima, Henrike Heise, Kazuo Kuwata, and Motomasa Tanaka + BIOCHEMISTRY 2395 Structural basis and energy landscape for the Ca2 + E2193 Entropy drives selective fluorine recognition in gating and calmodulation of the Kv7.2 K channel – the fluoroacetyl CoA thioesterase from Ganeko Bernardo-Seisdedos, Eider Nun˜ez, Carolina Gomis, Streptomyces cattleya Covadonga Malo, A´lvaro Villarroel, and Oscar Millet Amy M. Weeks, Ningkun Wang, Jeffrey G. Pelton, and Michelle C. Y. Chang CELL BIOLOGY E2202 Translational control in the tumor microenvironment E2238 Light-activated protein interaction with high spatial promotes lung metastasis: Phosphorylation of subcellular confinement eIF4E in neutrophils Lorena Benedetti, Andrew E. S. Barentine, Mirko Messa, Nathaniel Robichaud, Brian E. Hsu, Roman Istomine, Fernando Heather Wheeler, Joerg Bewersdorf, and Pietro De Camilli Alvarez, Julianna Blagih, Eric H. Ma, Sebastian V. Morales, David L. Dai, Glenn Li, Margarita Souleimanova, Qianyu Guo, E2246 STED nanoscopy of the centrosome linker reveals Sonia V. del Rincon, Wilson H. Miller Jr., Santiago Ramo´n y a CEP68-organized, periodic rootletin network Cajal, Morag Park, Russell G. Jones, Ciriaco A. Piccirillo, anchored to a C-Nap1 ring at centrioles Peter M. Siegel, and Nahum Sonenberg Rifka Vlijm, Xue Li, Marko Panic, Diana Ru¨thnick, Shoji Hata, E2210 Functional and physical interaction between yeast Frank Herrmannsdo¨rfer, Thomas Kuner, Mike Heilemann, Hsp90 and Hsp70 Johann Engelhardt, Stefan W. Hell, and Elmar Schiebel Andrea N. Kravats, Joel R. Hoskins, Michael Reidy, Jill L. 2401 Angiogenic patterning by STEEL, an endothelial- Johnson, Shannon M. Doyle, Olivier Genest, Daniel C. enriched long noncoding RNA Masison, and Sue Wickner H. S. Jeffrey Man, Aravin N. Sukumar, Gabrielle C. Lam, Paul J. 2359 Substrate binding to BamD triggers a conformational Turgeon, Matthew S. Yan, Kyung Ha Ku, Michelle K. Dubinsky, change in BamA to control membrane insertion J. J. David Ho, Jenny Jing Wang, Sunit Das, Nora Mitchell, Peter Oettgen, Michael V. Sefton, and Philip A. Marsden James Lee, Holly A. Sutterlin, Joseph S. Wzorek, Michael D. Mandler, Christine L. Hagan, Marcin Grabowicz, David DEVELOPMENTAL BIOLOGY Tomasek, Mary D. May, Elizabeth M. Hart, Thomas J. Silhavy, and Daniel Kahne E2165 Mitotic waves in the early embryogenesis of Drosophila: Bistability traded for speed 2365 Identification of the YEATS domain of GAS41 as Massimo Vergassola, Victoria E. Deneke, and Stefano Di Talia a pH-dependent reader of histone succinylation Yi Wang, Jing Jin, Matthew Wai Heng Chung, Ling Feng, E2254 Robo and Ror function in a common receptor Hongyan Sun, and Quan Hao complex to regulate Wnt-mediated neurite 2371 Irreversible inactivation of ISG15 by a viral leader outgrowth in Caenorhabditis elegans protease enables alternative infection Jiaming Wang and Mei Ding detection strategies 2407 Pulmonary alveolar type I cell population consists of Kirby N. Swatek, Martina Aumayr, Jonathan N. Pruneda, two distinct subtypes that differ in cell fate Linda J. Visser, Stephen Berryman, Anja F. Kueck, Paul P. Yanjie Wang, Zan Tang, Huanwei Huang, Jiao Li, Zheng Wang, Geurink, Huib Ovaa, Frank J. M. van Kuppeveld, Tobias J. Yuanyuan Yu, Chengwei Zhang, Juan Li, Huaping Dai, Tuthill, Tim Skern, and David Komander Fengchao Wang, Tao Cai, and Nan Tang

Contents PNAS u March 6, 2018 u vol. 115 u no. 10 u v Downloaded by guest on September 25, 2021 ECOLOGY IMMUNOLOGY AND INFLAMMATION E2264 Global rise in emerging alien species results from E2302 Carbon monoxide protects the kidney through the increased accessibility of new source pools central circadian clock and CD39 Hanno Seebens, Tim M. Blackburn, Ellie E. Dyer, Piero Matheus Correa-Costa, David Gallo, Eva Csizmadia, Edward Genovesi,PhilipE.Hulme,JonathanM.Jeschke,Shyama Gomperts, Judith-Lisa Lieberum, Carl J. Hauser, Xingyue Ji, Pagad, Petr Pysek, Mark van Kleunen, Marten Winter, Binghe Wang, Niels Olsen Saraiva Caˆmara, Simon C. Robson, Michael Ansong, Margarita Arianoutsou, Sven Bacher, Bernd and Leo E. Otterbein Blasius, Eckehard G. Brockerhoff, Giuseppe Brundu, Ce´sar E2311 Genetic rescue of lineage-balanced blood cell Capinha, Charlotte E. Causton, Laura Celesti-Grapow, Wayne Dawson, Stefan Dullinger, Evan P. Economo, Nicol production reveals a crucial role for STAT3 Fuentes, Benoit Gue´nard, Heinke Ja¨ger, John Kartesz, Marc antiinflammatory activity in hematopoiesis Kenis, Ingolf Ku¨hn, Bernd Lenzner, Andrew M. Liebhold, Huiyuan Zhang, Haiyan S. Li, Emily J. Hillmer, Yang Zhao, Alexander Mosena, Dietmar Moser, Wolfgang Nentwig, Taylor T. Chrisikos, Hongbo Hu, Xiao Wu, Erika J. Thompson, Misako Nishino, David Pearman, Jan Pergl, Wolfgang Karen Clise-Dwyer, Karen A. Millerchip, Yue Wei, Nahum Rabitsch, Julissa Rojas-Sandoval, Alain Roques, Stephanie Puebla-Osorio, Saakshi Kaushik, Margarida A. Santos, Bin Rorke, Silvia Rossinelli, Helen E. Roy, Riccardo Scalera, Wang, Guillermo Garcia-Manero, Jing Wang, Shao-Cong Sun,  Stefan Schindler, Katerina Stajerova´, Barbara and Stephanie S. Watowich Tokarska-Guzik, Kevin Walker, Darren F. Ward, Takehiko E2320 Role of glutathione metabolism in host defense Yamanaka, and Franz Essl against Borrelia burgdorferi infection See Commentary on page 2270 Mariska Kerstholt, Hedwig Vrijmoeth, Ekta Lachmandas, Marije 2299 Optically functional isoxanthopterin crystals in the Oosting, Mihaela Lupse, Mirela Flonta, Charles A. Dinarello, mirrored eyes of decapod crustaceans Mihai G. Netea, and Leo A. B. Joosten Benjamin A. Palmer, Anna Hirsch, Vlad Brumfeld, Eliahu D. E2329 MHC-mismatched mixed chimerism restores Aflalo, Iddo Pinkas, Amir Sagi, Shaked Rosenne, Dan Oron, peripheral tolerance of noncross-reactive Leslie Leiserowitz, Leeor Kronik, Steve Weiner, and Lia Addadi autoreactive T cells in NOD mice 2413 Demographic compensation does not rescue Mingfeng Zhang, Jeremy J. Racine, Qing Lin, Yuqing Liu, populations at a trailing range edge Shanshan Tang, Qi Qin, Tong Qi, Arthur D. Riggs, and Defu Zeng Seema Nayan Sheth and Amy Lauren Angert 2443 Signal peptide of HIV envelope protein impacts 2419 Trophic redundancy reduces vulnerability to glycosylation and antigenicity of gp120 extinction cascades Jason Yolitz, Catherine Schwing, Julia Chang, Donald Van Ryk, Dirk Sanders, Elisa The´bault, Rachel Kehoe, Fatima Nawaz, Danlan Wei, Claudia Cicala, James Arthos, and F. J. Frank van Veen and Anthony S. Fauci 2449 Neutrophils recruited through high endothelial venules of the lymph nodes via PNAd intercept EVOLUTION disseminating Staphylococcus aureus E2274 The timescale of early land plant evolution Ania Bogoslowski, Eugene C. Butcher, and Paul Kubes Jennifer L. Morris, Mark N. Puttick, James W. Clark, Dianne See Commentary on page 2272 Edwards, Paul Kenrick, Silvia Pressel, Charles H. Wellman, 2455 Tim-3 co-stimulation promotes short-lived effector Ziheng Yang, Harald Schneider, and Philip C. J. Donoghue T cells, restricts memory precursors, and is E2284 Climate-mediated hybrid zone movement revealed dispensable for T cell exhaustion with genomics, museum collection, and Lyndsay Avery, Jessica Filderman, Andrea L. Szymczak-Workman, simulation modeling and Lawrence P. Kane Sean F. Ryan, Jillian M. Deines, J. Mark Scriber, Michael E. Pfrender, Stuart E. Jones, Scott J. Emrich, and Jessica J. Hellmann MEDICAL SCIENCES 2425 Select and resequence reveals relative fitness of E2338 Sarcomeric perturbations of myosin motors lead to bacteria in symbiotic and free-living environments dilated cardiomyopathy in genetically modified Liana T. Burghardt, Brendan Epstein, Joseph Guhlin, Matt S. MYL2 mice Nelson, Margaret R. Taylor, Nevin D. Young, Michael J. Chen-Ching Yuan, Katarzyna Kazmierczak, Jingsheng Liang, Sadowsky, and Peter Tiffin Zhiqun Zhou, Sunil Yadav, Aldrin V. Gomes, Thomas C. Irving, and Danuta Szczesna-Cordary E2348 Epigenetic alterations in longevity regulators, GENETICS reduced life span, and exacerbated aging-related E2292 NLR surveillance of essential SEC-9 SNARE proteins pathology in old father offspring mice induces programmed cell death upon allorecognition Kan Xie, Devon P. Ryan, Brandon L. Pearson, Kristin S. Henzel, in filamentous fungi Frauke Neff, Ramon O. Vidal, Magali Hennion, Isabelle Lehmann, Melvin Schleif, Susanne Schro¨der, Thure Adler, Jens Heller, Corinne Clave´, Pierre Gladieux, Sven J. Saupe, Birgit Rathkolb, Jan Rozman, Anna-Lena Schutz, Cornelia and N. Louise Glass ¨ Prehn, Michel E. Mickael, Marco Weiergra¨ber, Jerzy Adamski, 2431 Unleashing meiotic crossovers in hybrid plants Dirk H. Busch, Gerhard Ehninger, Anna Matynia, Walker S. Joiselle Blanche Fernandes, Mathilde Se´gue´la-Arnaud, Ce´cile Jackson, Eckhard Wolf, Helmut Fuchs, Valerie Gailus-Durner, Larcheveˆque, Andrew H. Lloyd, and Raphael Mercier Stefan Bonn, Martin Hrabe de Angelis, and Dan Ehninger 2437 Massive crossover elevation via combination of HEI10 E2358 Diagnostic utility of telomere length testing in and recq4a recq4b during Arabidopsis meiosis a hospital-based setting Heı¨di Serra, Christophe Lambing, Catherine H. Griffin, Jonathan K. Alder, Vidya Sagar Hanumanthu, Margaret A. Stephanie D. Topp, Divyashree C. Nageswaran, Strong, Amy E. DeZern, Susan E. Stanley, Clifford M. Takemoto, Charles J. Underwood, Piotr A. Ziolkowski, Mathilde Ludmilla Danilova, Carolyn D. Applegate, Stephen G. Bolton, Se´gue´la-Arnaud, Joiselle B. Fernandes, Raphae¨l Mercier, David W. Mohr, Robert A. Brodsky, James F. Casella, Carol W. and Ian R. Henderson Greider, J. Brooks Jackson, and Mary Armanios

vi u www.pnas.org Contents Downloaded by guest on September 25, 2021 2461 Viral insulin-like peptides activate human insulin and E2403 Environmental enrichment and exercise are better IGF-1 receptor signaling: A paradigm shift for than social enrichment to reduce memory deficits host–microbe interactions in amyloid beta neurotoxicity Emrah Altindis, Weikang Cai, Masaji Sakaguchi, Fa Zhang, Mariza G. Prado Lima, Helen L. Schimidt, Alexandre Garcia, Wang GuoXiao, Fa Liu, Pierre De Meyts, Vasily Gelfanov, Hui Letı´cia R. Dare´, Felipe P. Carpes, Ivan Izquierdo, Pan, Richard DiMarchi, and C. Ronald Kahn and Paˆmela B. Mello-Carpes 2467 Molecular signatures of circulating melanoma cells E2410 Long-term potentiation expands information content for monitoring early response to immune of hippocampal dentate gyrus synapses checkpoint therapy Cailey Bromer, Thomas M. Bartol, Jared B. Bowden, Dusten D. Xin Hong, Ryan J. Sullivan, Mark Kalinich, Tanya Todorova Hubbard, Dakota C. Hanka, Paola V. Gonzalez, Masaaki Kwan, Anita Giobbie-Hurder, Shiwei Pan, Joseph A. LiCausi, Kuwajima, John M. Mendenhall, Patrick H. Parker, Wickliffe C. John D. Milner, Linda T. Nieman, Ben S. Wittner, Uyen Ho, Abraham, Terrence J. Sejnowski, and Kristen M. Harris Tianqi Chen, Ravi Kapur, Donald P. Lawrence, Keith T. Flaherty, 2502 Within- and across-trial dynamics of human EEG reveal Lecia V. Sequist, Sridhar Ramaswamy, David T. Miyamoto, cooperative interplay between reinforcement Michael Lawrence, Mehmet Toner, Kurt J. Isselbacher, Shyamala Maheswaran, and Daniel A. Haber learning and working memory Anne G. E. Collins and Michael J. Frank 2473 Theory of signs and statistical approach to big data in assessing the relevance of clinical biomarkers of 2508 Controlling of glutamate release by neuregulin3 via inflammation and oxidative stress inhibiting the assembly of the SNARE complex Ya-Nan Wang, Dwight Figueiredo, Xiang-Dong Sun, Zhao-Qi Pietro Ghezzi, Kevin Davies, Aidan Delaney, Dong, Wen-Bing Chen, Wan-Peng Cui, Fang Liu, Hong-Sheng and Luciano Floridi Wang, Hai-Wen Li, Heath Robinson, Er-Kang Fei, Bing-Xing 2478 Transcriptional factor ICER promotes glutaminolysis Pan, Bao-Ming Li, Wen-Cheng Xiong, and Lin Mei and the generation of Th17 cells 2514 Adult-born neurons boost odor–reward association Michihito Kono, Nobuya Yoshida, Kayaho Maeda, Anne Grelat, Laura Benoit, Se´bastien Wagner, Carine and George C. Tsokos Moigneu, Pierre-Marie Lledo, and Mariana Alonso

MICROBIOLOGY PHARMACOLOGY E2366 Rocaglates as dual-targeting agents for experimental E2419 Structure-based discovery of selective positive cerebral malaria allosteric modulators of antagonists for the David Langlais, Regina Cencic, Neda Moradin, James M. M2 muscarinic acetylcholine receptor Kennedy, Kodjo Ayi, Lauren E. Brown, Ian Crandall, Michael J. Magdalena Korczynska, Mary J. Clark, Celine Valant, Jun Xu, Tarry, Martin Schmeing, Kevin C. Kain, John A. Porco Jr., Ee Von Moo, Sabine Albold, Dahlia R. Weiss, Hayarpi Jerry Pelletier, and Philippe Gros Torosyan, Weijiao Huang, Andrew C. Kruse, Brent R. Lyda, E2376 In vivo repressed genes of Vibrio cholerae reveal Lauren T. May, Jo-Anne Baltos, Patrick M. Sexton, Brian K. + − inverse requirements of an H /Cl transporter Kobilka, Arthur Christopoulos, Brian K. Shoichet, along the gastrointestinal passage and Roger K. Sunahara Fatih Cakar, Franz G. Zingl, Manuel Moisi, Joachim Reidl, and Stefan Schild PHYSIOLOGY E2386 Defining the sizes of airborne particles that mediate E2429 Placental physiology monitored by hyperpolarized 13 influenza transmission in ferrets dynamic C magnetic resonance Jie Zhou, Jianjian Wei, Ka-Tim Choy, Sin Fun Sia, Dewi K. Stefan Markovic, Anne Fages, Tangi Roussel, Ron Hadas, Rowlands, Dan Yu, Chung-Yi Wu, William G. Lindsley, Alexander Brandis, Michal Neeman, and Lucio Frydman Benjamin J. Cowling, James McDevitt, Malik Peiris, Yuguo Li, E2437 Desynchrony between brain and peripheral clocks and Hui-Ling Yen caused by CK1δ/e disruption in GABA neurons does 2484 MotAB-like machinery drives the movement of MreB not lead to adverse metabolic outcomes filaments during bacterial gliding motility Vincent van der Vinne, Steven J. Swoap, Thomas J. Vajtay, Guo Fu, Jigar N. Bandaria, Anne Vale´rie Le Gall, Xue Fan, and David R. Weaver Ahmet Yildiz, Taˆm Mignot, David R. Zusman, and Beiyan Nan 2490 The secreted metabolome of Streptomyces PLANT BIOLOGY chartreusis and implications for bacterial chemistry E2447 Transcriptome dynamics at Arabidopsis graft Christoph H. R. Senges, Arwa Al-Dilaimi, Douglas H. junctions reveal an intertissue recognition Marchbank, Daniel Wibberg, Anika Winkler, Brad Haltli, mechanism that activates vascular regeneration Minou Nowrousian, Jo¨rn Kalinowski, Russell G. Kerr, Charles W. Melnyk, Alexander Gabel, Thomas J. Hardcastle, and Julia E. Bandow Sarah Robinson, Shunsuke Miyashima, Ivo Grosse, 2496 Structures of the prefusion form of measles virus and Elliot M. Meyerowitz fusion protein in complex with inhibitors E2457 Distinct sets of tethering complexes, SNARE Takao Hashiguchi, Yoshinari Fukuda, Rei Matsuoka, Daisuke complexes, and Rab GTPases mediate membrane Kuroda, Marie Kubota, Yuta Shirogane, Shumpei Watanabe, fusion at the vacuole in Arabidopsis Kouhei Tsumoto, Daisuke Kohda, Richard Karl Plemper, Kodai Takemoto, Kazuo Ebine, Jana Christin Askani, Falco and Yusuke Yanagi Kru¨ger, Zaida Andre´s Gonzalez, Emi Ito, Tatsuaki Goh, Karin Schumacher, Akihiko Nakano, and Takashi Ueda NEUROSCIENCE 2520 Membrane protein MHZ3 stabilizes OsEIN2 in rice by E2393 Axogenic mechanism enhances retinal ganglion cell interacting with its Nramp-like domain excitability during early progression in glaucoma Biao Ma, Yang Zhou, Hui Chen, Si-Jie He, Yi-Hua Huang, He Michael L. Risner, Silvia Pasini, Melissa L. Cooper, Wendi S. Zhao, Xiang Lu, Wan-Ke Zhang, Jin-Huan Pang, Shou-Yi Chen, Lambert, and David J. Calkins and Jin-Song Zhang

Contents PNAS u March 6, 2018 u vol. 115 u no. 10 u vii Downloaded by guest on September 25, 2021 SYSTEMS BIOLOGY 2532 A comprehensive model for the proliferation– E2467 Fundamental limits on dynamic inference from quiescence decision in response to endogenous single-cell snapshots DNA damage in human cells Caleb Weinreb, Samuel Wolock, Betsabeh K. Tusi, Merav Frank S. Heldt, Alexis R. Barr, Sam Cooper, Chris Bakal, Socolovsky, and Allon M. Klein and Be´la Nova´k E2477 Cooption of heat shock regulatory system for anhydrobiosis in the sleeping chironomid CORRECTIONS (ONLINE ONLY) Polypedilum vanderplanki EVOLUTION Pavel V. Mazin, Elena Shagimardanova, Olga Kozlova, Alexander Cherkasov, Roman Sutormin, Vita V. Stepanova, E2487 Gut microbiomes and reproductive isolation Alexey Stupnikov, Maria Logacheva, Aleksey Penin, in Drosophila Yoichiro Sogame, Richard Cornette, Shoko Tokumoto, Philip T. Leftwich, Naomi V. E. Clarke, Matthew I. Hutchings, Yugo Miyata, Takahiro Kikawada (黄川田 隆洋), Mikhail S. and Tracey Chapman Gelfand,andOlegGusev E2488 Structural complexity and molecular heterogeneity of 2526 Metabolic division of labor in microbial systems a butterfly ejaculate reflect a complex history of selection Ryan Tsoi, Feilun Wu, Carolyn Zhang, Sharon Bewick, David Camille Meslin, Tamara S. Cherwin, Melissa S. Plakke, Brandon S. Karig, and Lingchong You Small, Breanna J. Goetz, Nathan I. Morehouse, and Nathan L. Clark

viii u www.pnas.org Contents Downloaded by guest on September 25, 2021