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Direct-Ink-Writing of Degradable Carboxymethylcellulose

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Direct-Ink-Writing of Degradable Carboxymethylcellulose Available online at www.sciencedirect.com Available online at www.sciencedirect.com ScienceDirect ScienceDirect AvailableAvailableProcedia online online Manufacturing at at www.sciencedirect.com www.sciencedirect.com00 (2018) 000–000 Procedia Manufacturing 00 (2018) 000–000 www.elsevier.com/locate/procedia www.elsevier.com/locate/procedia ScienceDirectScienceDirect Procedia Manufacturing 26 (2018) 993–1002 Procedia Manufacturing 00 (2017) 000–000 www.elsevier.com/locate/procedia 46th SME North American Manufacturing Research Conference, NAMRC 46, Texas, USA 46th SME North American Manufacturing Research Conference, NAMRC 46, Texas, USA Direct-Ink-Writing of Degradable Carboxymethylcellulose Direct-Ink-Writing of Degradable Carboxymethylcellulose ManufacturingAlyssa Brandley Engineeringa, Robyn Society Hollfelder Internbational, Sepehr Conference Nesaei c2017,, Bernard MESIC VanWie 2017, 28-30b, Nehal June a 2017, Vigo (Pontevedra),b Spainc b Alyssa Brandley , Robyn AbuHollfelder-Lailb, B., Sepehr Arda GozenNesaeic,*, Bernard VanWie , Nehal Abu-Lailb, B. Arda Gozenc,* Costing modelsaBiomedical for Engineering capacity Department, optimiza Rowan University,tion Glassboro, in IndustryNJ, 08028, United 4.0:States Trade-off bVoiland School ofaBiomedical Chemical Engineering andDepartment,Bioengineering, Rowan WashingtonUniversity, Glassboro, State University, NJ, 08028, Pullman,WA United States , 99164, United States bVoilandcSchool Schoolbetween of Mechanicalof Chemical and Engineeringused Materials capacity and EngineeringBioengineering,, Washington an Washingtond operationalState University,State University, Pullman,WA Pullman,WA efficiency , 99164, , 991 United64, United States States cSchool of Mechanical and Materials Engineering, Washington State University, Pullman,WA , 99164, United States * Corresponding author. Tel.: +1-A.509 -Santana335-3214; fax:a, +1-P. 509Afonso-335- 4662a,*, A. Zaninb, R. Wernkeb * CorrespondingE-mail address: [email protected] Tel.: +1-509-335-3214; fax: +1-509-335- 4662 E-mail address: [email protected] a University of Minho, 4800-058 Guimarães, Portugal bUnochapecó, 89809-000 Chapecó, SC, Brazil Abstract Abstract Additive manufacturing with degradable polymers have recently drawn significant attention due to its promising biomedical AbstractapplicationsAdditive manufacturing including artificial with degradable tissue engineering, polymers surgical have ,recently and orthopedic drawn significantdevices etc. attention This paper due experimentally to its promising investigates biomedical the direct-ink-writingapplications including of one artificial of the tissue widely engineering, used degradable surgical , polymers,and orthopedic carboxymethlycellulose. devices etc. This paper Through experimentally printing investigatesand geometric the Undercharacterizationdirect-ink-writing the conceptof ofsimple oneof "Industrytest of the structures, widely 4.0", effectused production degradableof ink concentration, proce polymers,sses substrate willcarboxymethlycellulose. be materialpushed and to directbe Throughincreasingly-ink-writing printing process interconnected, and parametersgeometric informationcharacterizationincluding printing basedof pressure,simple on a realtest printing structures,time speedbasis effect andand, nozzleof necessarily, ink concentration,substrate much distance substratemore on efficient.the material process In and outcome this direct context, -isink studied.-writing capacity Preliminary process optimization parameters findings goesonincluding printing beyond printing of themicro traditional pressure,-scale structures printing aim of usingspeed capacity nozzlesand maximization,nozzle as small substrate as 10 contributingdistance µm in diameter on the also process are for also organization’s outcome presented. is studied. profitability Preliminary and find value.ings Indeed,on printing lean of micromanagement-scale structures and continuoususing nozzles improvementas small as 10 µapproachesm in diameter suggestare also presented.capacity optimization instead of © 2018 The Authors. Published by Elsevier B.V. maximization.© 2018 The Authors. The studyPublished of capacityby Elsevier optimization B.V. and costing models is an important research topic that deserves © 2018 The Authors. Published by Elsevier B.V. contributionsPeer-reviewPeer-review underunder from responsibilityresponsibility both the practical of of the the scientifc scientific and theoretical committee committee perspectives.of of the NAMRI/SME 46th SME This North. paper American presents Manufacturing and discusses Research a mathematical Conference. Peer-review under responsibility of the scientific committee of NAMRI/SME. model for capacity management based on different costing models (ABC and TDABC). A generic model has been Keywords: Micro-additive manufacturing; biodegradable; hydrogels; micro-extrusion; 3D-printing developedKeywords: Micro and -itadditive was used manufacturing; to analyze biodegradable; idle capacity hydrogels; and to micro design-extrusion; strategies 3D-printing towards the maximization of organization’s value. The trade-off capacity maximization vs operational efficiency is highlighted and it is shown that capacity optimization1. Introduction might hide operational inefficiency. biodegradable polymers. Conventional polymer ©1. 2017Introduction The Authors. Published by Elsevier B.V. processingbiodegrada blemethods polymers. have been Conventional successfully usedpolymer for Peer-reviewBiodegradable under responsibility polymers have of the been scientific widely committee used in of the Manufacturingsucprocessingh materials Engineeringmethods in the have Society past been decades.International successfully More Conference recently,used for 2017. a myriadBiodegradable of applications polymers including have been surgical widely, implanted used in emergencesuch materials of in biomedicalthe past decades. device Moretechnologies recently, a myriad of applications including surgical, implanted emergence of biomedical device technologies Keywords:and orthopedic Cost Models; devices, ABC; TDABC; drug Capacity delivery Management; systems, Idle Capacity;requiring Operational complex,Efficiency multi-material and personalized artificialand orthopedic tissue engineering devices, anddrug food delivery packaging systems,[1,2]. partsrequiring with complex,micron-level multi feature-material sizes, and led personalizedto increased Theartificial importance tissue engineeringof such applications and food directly packaging involving[1,2]. researchparts with and micron technological-level feature investment sizes, led in tothe increa additivesed humanThe1. Introduction importance health brought of such the applications need for accurate directly and involving robust manufacturingresearch and technological with biodegradable investment polymers. in the additive manufacturinghuman health brought technologies the need for accuratefor processingand robust manufacturing with biodegradable polymers. manufacturingThe cost of idle capacitytechnologies is a fundamental for processing information for companies and their management of extreme importance in2351 modern-9789 © production 2018 The Authors. systems. Published In general, by Elsevier it is B.V. defined as unused capacity or production potential and can be measured inPeer-2351 several-review9789 © underways: 2018 responsibilityThe tons Authors. of production, ofPublished the scientific by Elsevieravailable committee B.V. hours of NAMRI/SME of manufacturing,. etc. The management of the idle capacity Peer-* Pauloreview Afonso. under Tel.: responsibility +351 253 of510 the 761; scientific fax: +351 committee 253 604 of 741 NAMRI/SME . E-mail address: [email protected] 2351-9789 © 2017 The Authors. Published by Elsevier B.V. Peer-review under responsibility of the scientific committee of the Manufacturing Engineering Society International Conference 2017. 2351-9789 © 2018 The Authors. Published by Elsevier B.V. Peer-review under responsibility of the scientifc committee of the 46th SME North American Manufacturing Research Conference. 10.1016/j.promfg.2018.07.130 10.1016/j.promfg.2018.07.130 2351-9789 994 Alyssa Brandley et al. / Procedia Manufacturing 26 (2018) 993–1002 2 Author name / Procedia Manufacturing 00 (2018) 000–000 Various commonly used polymer additive effects of the ink spreading and wetting of the substrate manufacturing techniques have been utilized for surface [16]. Authors’ recent work demonstrated the biodegradable materials. These methods include, effect of the viscoelasticity on the flow of the inks and powder bed processing methods such as selective laser the underlying deposition mechanisms during DIW, sintering and melting [3,4] and binder jetting [5], vat- which can be anywhere between pure extrusion and photopolymerization methods such stereolithography pure fiber drawing depending on the process and [6] and extrusion-based methods such as fused- material parameters [17]. deposition modelling [7] and direct-ink-writing (DIW) During DIW of biodegradable polymers, the inks [8]. Primary application of the additively are usually prepared in the form of concentrated water manufactured parts have been the artificial tissue solutions of the polymers that gellate through water scaffolds [9] which are complex porous structures that loss or another cross-linking process such as UV- are implanted in the patients’ body and facilitate the curing [18]. The functional biomaterials are suspended tissue growth in a particular geometry
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