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Generate Metabolic Map Poster Authors: Pallavi Subhraveti Ron Caspi Peter Midford Peter D Karp An online version of this diagram is available at BioCyc.org. Biosynthetic pathways are positioned in the left of the cytoplasm, degradative pathways on the right, and reactions not assigned to any pathway are in the far right of the cytoplasm. Transporters and membrane proteins are shown on the membrane. Ingrid Keseler Periplasmic (where appropriate) and extracellular reactions and proteins may also be shown. Pathways are colored according to their cellular function. Gcf_007970805Cyc: Flavisolibacter ginsenosidimutans Gsoil 636 Cellular Overview Connections between pathways are omitted for legibility. Anamika Kothari fluoride phosphate D-ribose arsenite ethanolamine a dipeptide CrcB RbsC ArsB Eat RS18440 RS05465 fluoride phosphate D-ribose arsenite ethanolamine a dipeptide ditrans,octacis- a peptidoglycan with a peptidoglycan dimer (meso ditrans,octacis- lipid II (meso UDP-N-acetyl- (4R)-4-hydroxy- a [protein]- a [protein]-L- a lipid II an L-asparaginyl- an L-cysteinyl- undecaprenyldiphospho- (L-alanyl-γ-D-glutamyl- -diaminopimelate containing) undecaprenyldiphospho- diaminopimelate α-D-muramoyl- 2-oxoglutarate L-tyrosine methionine [tRNA Asn ] [tRNA Cys ] TCA cycle TCA cycle I (prokaryotic) N-acetyl-(N-acetyl-β-D- L-lysyl-D-alanyl-D- N-acetyl-(N- containing) L-alanyl-γ-D- polysaccharide peptide- Metabolic Regulator Biosynthesis inosine 5'-phosphate Nucleoside and Nucleotide Degradation gln Aminoacyl-tRNA Charging guanosine nucleotides alanine) pentapeptide biosynthesis methionine glutaminyl-tRNA biosynthesis via transamidation degradation glucosaminyl)muramoyl- D-alanyl-D-alanine acetylglucosaminyl) glutamyl-meso-2,6- D-alanyl-D-alanine degradation III γ γ bifunctional tyrosine (S)-S-oxide acetyl-CoA L-alanyl- -D-glutamyl-L- carboxypeptidase/ muramoyl-L-alanyl- - peptidoglycan diaminopimeloyl- carboxypeptidase/ aminoacyl- aminoacyl- trehalose biosynthesis I β 4-hydroxy-2- autokinase: reductase lysyl-D-alanyl-D-alanine D-alanyl-D-alanine- D-isoglutaminyl-N-( - synthetase: D-alanyl-D-alanine D-alanyl-D-alanine- tRNA tRNA glu trehalose trehalose IMP oxoglutarate FSB75_RS02685 MsrA: msrA GMP endopeptidase: dacB D-asparaginyl)-L-lysyl- FSB75_RS05360 endopeptidase: dacB hydrolase: hydrolase: D-glucopyranose biosynthesis V biosynthesis IV oxaloacetate IMP aldolase/2- UDP-α-D-glucose monofunctional D-alanyl-D-alanine arfB arfB polysaccharide peptide- 6-phosphate citrate (Si)-synthase, dehydrogenase: bifunctional UTP and CTP dephosphorylation I penicillin-binding monofunctional D-alanyl-D-alanine penicillin- dehydro-3-deoxy- a glycogen biosynthesis methionine α-maltose eukaryotic: guaB metallophosphatase/ biosynthetic protein 2: mrdA biosynthetic carboxypeptidase/ binding phosphogluconate aminoacyl-tRNA aminoacyl-tRNA glycogen peptidoglycan tyrosine (S)-S-oxide bifunctional maltose alpha-D- FSB75_RS02310 XMP 5'-nucleotidase: UTP monofunctional peptidoglycan D-alanyl-D-alanine- protein aldolase: hydrolase: hydrolase: debranching transglycosylase: autokinase: reductase an L-glutamyl- alpha,alpha- glucosyltransferase: FSB75_RS15255 a peptidoglycan with biosynthetic transglycosylase: endopeptidase: dacB 2: mrdA FSB75_RS00210 FSB75_RS13450 FSB75_RS13450 Gln protein malate mtgA FSB75_RS11480 MsrA: msrA gln [tRNA ] trehalose- treS bifunctional 5'/3'-nucleotidase CTP synthase: D,D cross-links (meso- D-ala peptidoglycan mtgA penicillin- a [protein]- a protein-L- GlgX: glgX α α dehydrogenase: mdh , -trehalose SurE: surE FSB75_RS21390 diaminopimelate containing) transglycosylase: binding L-tyrosine methionine- Asp-tRNA(Asn) phosphate a maltodextrin metallophosphatase/ a N- Asp-tRNA(Asn) guanosine di-trans,octa-cis mtgA Asn a tRNA Cys /Glu-tRNA(Gln) synthase (UDP- (S)-malate citrate 5'-nucleotidase: UDP a peptidoglycan with lipid II (meso di-trans,octa-cis protein D-ala acetylglucosamine- glyoxylate pyruvate asn tRNA cys phosphate (S)-S-oxide /Glu-tRNA(Gln) γ -undecaprenyl amidotransferase forming)/trehalose- malto- FSB75_RS15255 CTP (L-alanyl- -D-glutamyl- diaminopimelate -undecaprenyl 2: mrdA -N-acetylmuramyl- amidotransferase purine-nucleoside diphosphate subunit GatC: gatC phosphatase: oligosyltrehalose 5'/3'-nucleotidase L-lysyl-D-alanyl-D- a peptidoglycan di-trans,octa-cis containing) diphosphate (tetrapeptide) subunit GatC: gatC synthase: treY phosphorylase: alanine) pentapeptide dimer (E. faeciums) -undecaprenyl [+ 2 isozymes] FSB75_RS03915 SurE: surE UDP-N- pyrophosphoryl- [+ 13 isozymes] aconitate hydratase: FSB75_RS20255 UMP diphosphate undecaprenol a 5-phosphooxy- a maltooligosyl- CDP D-ala acetylmuramoyl- α,α-trehalose FSB75_RS04100 ammonium L-glutamyl- trehalose class II fumarate xanthosine bifunctional L-alanyl-γ-D- Gln guanine [tRNA ] 6-phosphate malto- hydratase: fumC metallophosphatase/ glutamyl-meso-2,6- bifunctional oligosyltrehalose fumarate cis-aconitate purine-nucleoside 5'-nucleotidase: diaminopimeloyl- Asp-tRNA(Asn) D-alanine alpha,alpha- trehalohydrolase: aconitate hydratase: phosphorylase: CMP FSB75_RS15255 /Glu-tRNA(Gln) succinate trehalose- treZ FSB75_RS04100 FSB75_RS20255 bifunctional 5'/3'-nucleotidase amidotransferase dehydrogenase/ ω phosphate metallophosphatase/ SurE: surE a peptidoglycan ditrans,octacis- Nα,Nε-diacetyl-lysyl- a [bis(guanylyl β-D-fructofuranose 6-O-trans- an N -(1- D-sedoheptulose subunit GatC: gatC α,α-trehalose fumarate reductase xanthine xanthine UDP-N-acetyl-α-D-muramoyl- D-alanyl-D-alanine synthase (UDP- methoxy-mycolyl- sec 5'-nucleotidase: uridine L-alanyl-γ-D-glutamyl-L-lysine dimer (E. faeciums) undecaprenyldiphospho- D-alanyl-D-alanine molybdopterin) cys 1-phosphate hydroxy-2- 1-phosphate ATP roseoflavin ser a tRNA [+ 2 isozymes] tRNA charging forming)/trehalose- iron-sulfur subunit: trehalose 6- FSB75_RS15255 N-acetyl-(N- cofactor oxopropyl) 5'-phosphate phosphatase: FSB75_RS01585 phosphate 5'/3'-nucleotidase D-alanyl-D-alanine acetylglucosaminyl) chaperone]- bifunctional -[protein]- an L-glutaminyl- FSB75_RS03915 succinate D-threo-isocitrate bifunctional UDP-N- muramoyl-L-alanyl- D-alanyl-D-alanine L-cysteine class I fructose- L-arginine class I fructose- Phe SurE: surE carboxypeptidase/ alpha,alpha- serine- [tRNA Gln ] phe a tRNA isocitrate acetylmuramoyl-tripeptide:D- γ carboxypeptidase/ bisphosphate bisphosphate bifunctional α α urate urate D-alanyl-D-alanine- -D-isoglutaminyl- trehalose- -tRNA , -trehalose ADP-forming dehydrogenase cytidine alanyl-D-alanine ligase/ β D-alanyl-D-alanine- aldolase: aldolase: endopeptidase: dacB N-( -D-asparaginyl) phosphate DJ-1/PfpI/YhbO riboflavin kinase/ ligase: succinate--CoA ligase (NADP(+)): alanine racemase: endopeptidase: dacB IscS subfamily FSB75_RS00915 FSB75_RS00915 -L-lysyl-D-alanine synthase (UDP- family deglycase/ FAD synthetase: serS Gln phenylalanine- FSB75_RS11860 penicillin-binding cysteine gln a tRNA subunit beta: sucC FSB75_RS06195 penicillin- class II fructose- forming)/trehalose- class II fructose- FSB75_RS06735 -tRNA ligase protein 2: mrdA desulfurase: protease: ser a tRNA ser a tRNA Ala ala tRNA asp asp succinate--CoA ligase UDP-N-acetylmuramoyl- binding bisphosphate phosphatase: bisphosphate elongator subunit monofunctional FSB75_RS11880 FSB75_RS17980 arg a tRNA Arg val a tRNA Val thr a tRNA Thr met initiator tRNA Met met pro a tRNA Pro trp a tRNA Trp his a tRNA His glu a tRNA glu cys a tRNA Cys lys a tRNA Lys asn tRNA Asn leu a tRNA Leu ile a tRNA Ile gly a tRNA Gly tyr a tRNA Tyr subunit alpha: sucD thymine degradation purine ribonucleosides degradation tripeptide--D-alanyl- protein aldolase: fbaA trehalose- FSB75_RS03915 aldolase: fbaA roseoflavin an L-seryl- tRNA Met alpha: pheS biosynthetic glutamine-- D- alanine ligase: a peptidoglycan tetramer 2: mrdA cysteine [tRNA sec ] succinyl-CoA 2-oxoglutarate peptidoglycan trans-methoxy- adenine tRNA ligase/ serine- phenylalanine- alanine- aspartate- thymine FSB75_RS18925 with a D,D cross-link D-ala desulfurase: a [protein]- transglycosylase: mono-mycolate (R)-lactate dinucleotide arginine-- valine-- threonine- methionine- methionine- proline-- YqeY domain tryptophan- histidine-- glutamate-- cysteine-- lysine- asparagine- leucine-- -tRNA -tRNA ligase isoleucine-- -tRNA glycine-- -tRNA tyrosine-- dihydrothymine adenosine (Enterococcus faecium) FSB75_RS19760 DHAP D-glyceraldehyde L-arginine DHAP D-erythrose mtgA Nα,Nε-diacetyl- tRNA ligase: tRNA ligase: -tRNA -tRNA -tRNA tRNA ligase: fusion protein: -tRNA tRNA ligase: tRNA ligase: tRNA ligase: -tRNA -tRNA tRNA ligase: ligase: subunit beta: tRNA ligase: ligase: tRNA ligase: ligase: tRNA ligase: dehydrogenase: UDP-N-acetyl-α-D-muramoyl-L-alanyl- lysyl-D-alanine D-ala FSB75_RS01895 FSB75_RS02035 ligase: thrS ligase: metG ligase: metG FSB75_RS04590 FSB75_RS05555 ligase: trpS FSB75_RS11820 FSB75_RS13350 FSB75_RS14165 ligase: lysS ligase: asnS FSB75_RS17000 serS FSB75_RS20035 FSB75_RS18130 alaS FSB75_RS18395 aspS FSB75_RS21190 preA γ-D-glutamyl-L-lysyl-D-alanyl-D-alanine a [bis(guanylyl 2-oxoglutarate 5,6-dihydrothymine a peptidoglycan di-trans,octa-cis ala molybdopterin) an L-methionyl- dehydrogenase dimer (E. faecium -undecaprenyl cofactor an L-arginyl- an L-valyl- an L-threonyl- an L-methionyl- an L-prolyl- an L-glutaminyl- an L-tryptophanyl- an L-histidyl- an L-glutamyl- an L-cysteinyl- an L-lysyl- an L-asparaginyl- an L-leucyl- an L-seryl- an L-phenylalanyl- an L-isoleucyl- an L-alanyl- Gly an L-aspartyl- an L-tyrosyl- dihydropyrimidinase: Arg Val Thr [elongator Met Pro Gln Trp His Glu Cys Lys Asn Leu ser Phe Ile Ala a glycyl-[tRNA ] asp Tyr E1 component:
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