DOCSLIB.ORG

Quantification of Organophosphorus Pesticides by Quechers and LC

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Quantification of Organophosphorus Pesticides by Quechers and LC HPLC Application ID No.: 20020 Quantification of Organophosphorus Pesticides by QuEchERS and LC/MS/MS Column: Synergi™ 4 µm Fusion-RP 80 Å, LC Column 50 x 2 mm, Ea Dimensions: 50 x 2 mm ID Order No: 00B-4424-B0 Elution Type: Gradient Eluent A: Add 5mL of 1M ammonium formate to 1L Water Eluent B: Add 5mL of 1M ammonium formate to 1L Methanol Gradient Step No. Time (min) Pct A Pct B Profile: 1 -5 95 5 2 0 95 5 3 2 95 5 4 6 50 50 5 12 10 90 6 14 10 90 7 16 95 5 8 17 95 5 Flow Rate: 250 mL/min Col. Temp.: 25 °C Detection: Tandem Mass Spec (MS-MS) @ (ambient) Detector Info: <a target="_blank" href="https://sciex.com/products/mass-spectrometers?utm_campaign=2019%20application%20search&utm_source=phenomenex&utm_medium=referral">SCIEX</a> Analyst Note: SecurityGuard™ Guard Cartridge System extends column lifetime. - SecurityGuard Cartridges, Fusion-RP 4 x 2.0mm ID, 10/Pk Part No.: AJ0-7556 - Holder Part No.: KJ0-4282 ©2021 Phenomenex Inc. All rights reserved. For more information contact your Phenomenex Representative at [email protected] Phenomenex products are available worldwide. www.phenomenex.com [email protected] Page 1 of 2 HPLC Application ID No.: 20020 Quantification of Organophosphorus Pesticides by QuEchERS and LC/MS/MS ANALYTES: 1 Acephate (MRM: 184/142.8) 41 Diazinon (MRM: 305/169) 2 Acephate (MRM: 184/94.9) 42 Diazinon (MRM: 305/153) 3 Demeton-S-methyl sulfone (MRM: 263/169) 43 Fenthion (MRM: 278.9/169) 4 Demeton-S-methyl sulfone (MRM: 263/109) 44 Fenthion (MRM: 278.9/246.9) 5 Parathion-methyl Methyl parathion (MRM: 263.9/232.1)45 Coumaphos (MRM: 363/226.9) 6 Parathion-methyl Methyl parathion (MRM: 263.9/125)46 Coumaphos (MRM: 363/307) 7 Dicrotophos (MRM: 238/112) 47 Phorate (MRM: 261/75) 8 Dicrotophos (MRM: 238/193) 48 Phorate (MRM: 261/199) 9 Demeton-S-methyl (MRM: 231/89) 49 Pirimiphos-methyl (MRM: 306.1/164.1) 10 Demeton-S-methyl (MRM: 231/61) 50 Pirimiphos-methyl (MRM: 306.1/108) 11 Dimethoate (MRM: 230/198.9) 51 Pirimiphos-ethyl (MRM: 334/198.1) 12 Dimethoate (MRM: 230/124.9) 52 Pirimiphos-ethyl (MRM: 334/182.1) 13 Mevinphos (MRM: 225/127) 53 Sulprofos (MRM: 323/219) 14 Mevinphos (MRM: 225/193) 54 Sulprofos (MRM: 323/247) 15 Dichlorvos (DDVP) (MRM: 221/109) 55 Chlorpyrifos (MRM: 350/198) 16 Dichlorvos (DDVP) (MRM: 221/127) 56 Chlorpyrifos (MRM: 350/97) 17 Phorate sulfoxide (MRM: 277/199) 57 Tokuthion (MRM: 344.9/241) 18 Phorate sulfoxide (MRM: 277/97) 58 Tokuthion (MRM: 344.9/133) 19 Famphur (Famophos) (MRM: 326/217) 20 Famphur (Famophos) (MRM: 326/281) 21 Naled (isomer 1) (MRM: 381/127) 22 Naled (isomer 1) (MRM: 381/109) 23 Azinphos-methyl (Gusathion) (MRM: 318/132) 24 Azinphos-methyl (Gusathion) (MRM: 318/160) 25 Malathion (MRM: 331/127) 26 Malathion (MRM: 331/99) 27 Triazophos (MRM: 314/162) 28 Triazophos (MRM: 314/119) 29 Azinphos-ethyl (MRM: 346/132.1) 30 Azinphos-ethyl (MRM: 346/160.1) 31 Tetrachlorvinphos (Tetrachlorovinphos) (MRM:366.9/127) 32 Tetrachlorvinphos (Tetrachlorovinphos) (MRM:368.9/127) 33 EPTC (internal standard) (MRM: 190.1/86) 34 EPTC (internal standard) (MRM: 190.1/128) 35 Chlorfenvinphos (MRM: 359/155) 36 Chlorfenvinphos (MRM: 359/99) 37 Parathion Ethyl parathion (MRM: 292.1/236.2) 38 Parathion Ethyl parathion (MRM: 292.1/94.1) 39 Sulfotep (MRM: 323/115) 40 Sulfotep (MRM: 323/171.1) ©2021 Phenomenex Inc. All rights reserved. For more information contact your Phenomenex Representative at [email protected] Phenomenex products are available worldwide. www.phenomenex.com [email protected] Page 2 of 2.
Load more

Recommended publications
  • Agents for Defense Against Chemical Warfare: Reactivators of Acetylcholinesterase Inhibited with Neurotoxic Organophosphorus Compounds **
    Mil. Med. Sci. Lett. (Voj. Zdrav. Listy) 2015, vol. 84(3), p. 115-127 ISSN 0372-7025 DOI: 10.31482/mmsl.2015.013 REVIEW ARTICLE AGENTS FOR DEFENSE AGAINST CHEMICAL WARFARE: REACTIVATORS OF ACETYLCHOLINESTERASE INHIBITED WITH NEUROTOXIC ORGANOPHOSPHORUS COMPOUNDS ** Petronilho, E. C., Figueroa-Villar, J. D. Chemistry Engineering Section, Medicinal Chemistry Group, Military Institute of Engineering, Praça General Tibúrcio, 80, Urca, 22290-270, Rio de Janeiro, RJ, Brazil. Received 30 th April 2015. Revised 7 th July 2015. Published 4 th September 2015. Summary The chemical warfare agents and neurotoxic agents are an important threat to people all over the world, and require special attention because they are highly dangerous. Most of these agents are neurotoxic organophosphorus compounds (OP), which inhibit the enzyme acetylcholinesterase (AChE), which is responsible for controlling the transmission of nerve impulses. To be inhibited by these compounds, AChE can sometimes be reactivated using cationic oximes, which are the most used substances for this reactivation. Until today there have not been discovered agents for complete treatment of poisoning by all OPs. For this reason, the treatment of intoxicated people requires the determination of the absorbed OP, in order to select the appropriate activator, a process that usually requires long time and may cause death. Therefore, this study aims to do a review on the OPs used as chemical warfare agents and the process of inhibition and reactivation of AChE, especially to motivate the development of new agents for defense against chemical weapons, a process that is very important for protecting all humanity. Key words: acetylcholinesterase; AChE reactivators; organophosphorus; oximes; warfare agents INTRODUCTION pounds (OP), which are highly toxic, allowing their use with small quantities in order to cause seizures The use of chemical warfare agents is a major and death.
    [Show full text]
  • Development and Validation of a Method for the Simultaneous
    CORE Metadata, citation and similar papers at core.ac.uk Provided by UGD Academic Repository American Journal of Applie d Chemistry 2014; 2(4): 46-54 Published online August 10, 2014 (http://www.sciencepublishinggroup.com/j/ajac) doi: 10.11648/j.ajac.20140204.11 ISSN: 2330-8753 (Print); ISSN: 2330-8745 (Online) Development and validation of a method for the simultaneous determination of 20 organophosphorus pesticide residues in corn by accelerated solvent extraction and gas chromatography with nitrogen phosphorus detection Vesna Kostik *, Biljana Gjorgeska, Bistra Angelovska Medical Faculty, Department of Pharmacy, University “Goce Delchev”, Shtip, Republic of Macedonia Email address: [email protected] (V. Kostik), [email protected] (B. Gjorgeska), [email protected] (B. Angelovska) To cite this article: Vesna Kostik, Biljana Gjorgeska, Bistra Angelovska. Development and Validation of a Method for the Simultaneous Determination of 20 Organophosphorus Pesticide Residues in Corn by Accelerated Solvent Extraction and Gas Chromatography with Nitrogen Phosphorus Detection. American Journal of Applied Chemistry. Vol. 2, No. 4, 2014, pp. 46-54. doi: 10.11648/j.ajac.20140204.11 Abstract: The method for simultaneous determination of 20 organophosphorus pesticide residues in corn samples has been developed and validated. For the extraction of organophosporus pesticide residues from the samples, the accelerated solvent technique with the mixture of dichloromethane: acetone (1:1, V/V ) was used. Clean up was done using liquid – liquid extraction with n – hexane, followed by solid phase extraction on primary secondary amine adsorbent, and elution with the mixture of acetone: toluene (65:35). The determination of the pesticides was carried out by gas chromatography with nitrogen phosphorus detection.
    [Show full text]
  • Organophosphate Poisoning : a Review
    120 Sinha and Sharma Med J Indones Organophosphate poisoning : A review Parmod K. Sinha, Ashok Sharma Abstrak Pestisida organofosfat digunakan secara luas di seluruh dunia. Keracunan oleh bahan ini merupakan masalah kesehatan masyarakat, terutama di negara berkembang. Zat neurotoksik organofosfat merupakan bahan yang dianggap mengancam dalam bidang militer dan terorisme. Mekanisme toksisitas bahan ini adalah dengan cara menghambat asetilkolinesterase yang mengakibatkan menumpuknya neurotransmitor asetilkolin dan terjadi rangsangan terus-menerus pada reseptor asetilkolin pada sistem saraf sentral maupun perifer. Selain krisis kolinergik, organofosfat dapat menimbulkan berbagai sindrom neurologis, baik akut maupun kronik. Sedangkan gejala peralihan ( intermediate) terjadi 1-4 hari setelah krisis kolinergik teratasi. Pengobatan standar terdiri dari reaktivasi asetilkolinesterase dengan antidot golongan oksim (prolidoksim, oksidoksime, HI-6 dan HLo7), dan pengendalian efek biokimia asetilkolin dengan menggunakan atropin. Golongan oksim yang baru HI-6 dan Hlo7 merupakan reaktivator asetilkolinesterase yang lebih cocok dan efektif untuk keracunan akut dan berat dibandingkan dengan prolidoksim dan obidoksim. Penderita yang mendapat pengobatan segera, biasanya dapat sembuh dari toksisitas akut, namun gejala neurologis ikutan dapat saja terjadi. (Med J Indones 2003; 12: 120-6) Abstract Organophosphate pesticides are used extensively worldwide, and poisoning by these agents, particularly in developing nations is a public health problem. Organophosphorous
    [Show full text]
  • Guide No. 1 – October 2020 2/12 the CONCEPT and IMPLEMENTATION of CPA GUIDANCE RESIDUE LEVELS
    Cooperation Centre for Scientific Research Relative to Tobacco CORESTA GUIDE N° 1 The Concept and Implementation of CPA Guidance Residue Levels October 2020 Agro-Chemical Advisory Committee CORESTA TECHNICAL GUIDE N° 1 Title: The Concept and Implementation of CPA Guidance Residue Levels Status: Valid Note: This document will be periodically reviewed by CORESTA Document history: Date of review Information July 2003 Version 1 GRL for Pyrethrins () and Terbufos corrected. December 2003 CPA terminology corrected. June 2008 Version 2 – GRLs revised and residue definitions added Provisional GRL of 2.00 ppm for Cyfluthrin to replace previous June 2010 GRL of 0.50 ppm July 2013 Version 3 – GRLs revised October 2013 Note for Maleic Hydrazide revised Version 4 – GRLs revised + clarification that scope of GRLs July 2016 applies predominantly to the production of traditional cigarette tobaccos and GAP associated with their cultivation. June 2018 Fluopyram GRL of 5 ppm added to GRL list Version 5 – Nine new CPAs with GRL added to list. November 2019 Revision of GRLs for Chlorantraniliprole and Indoxacarb. Updated web links. October 2020 Version 6 – Flupyradifurone GRL of 21 ppm added to GRL list. CORESTA Guide No. 1 – October 2020 2/12 THE CONCEPT AND IMPLEMENTATION OF CPA GUIDANCE RESIDUE LEVELS Executive Summary • Guidance Residue Levels (GRLs) are in the remit of the Agro-Chemical Advisory Committee (ACAC) of CORESTA. Their development is a joint activity of all ACAC members, who represent the leaf production, processing and manufacturing sectors of the Tobacco Industry. The concept of GRLs and their implementation are described in this guide. • GRLs provide guidance to tobacco growers and assist with interpretation and evaluation of results from analyses of residues of Crop Protection Agents (CPAs*).
    [Show full text]
  • Chemical Name Federal P Code CAS Registry Number Acutely
    Acutely / Extremely Hazardous Waste List Federal P CAS Registry Acutely / Extremely Chemical Name Code Number Hazardous 4,7-Methano-1H-indene, 1,4,5,6,7,8,8-heptachloro-3a,4,7,7a-tetrahydro- P059 76-44-8 Acutely Hazardous 6,9-Methano-2,4,3-benzodioxathiepin, 6,7,8,9,10,10- hexachloro-1,5,5a,6,9,9a-hexahydro-, 3-oxide P050 115-29-7 Acutely Hazardous Methanimidamide, N,N-dimethyl-N'-[2-methyl-4-[[(methylamino)carbonyl]oxy]phenyl]- P197 17702-57-7 Acutely Hazardous 1-(o-Chlorophenyl)thiourea P026 5344-82-1 Acutely Hazardous 1-(o-Chlorophenyl)thiourea 5344-82-1 Extremely Hazardous 1,1,1-Trichloro-2, -bis(p-methoxyphenyl)ethane Extremely Hazardous 1,1a,2,2,3,3a,4,5,5,5a,5b,6-Dodecachlorooctahydro-1,3,4-metheno-1H-cyclobuta (cd) pentalene, Dechlorane Extremely Hazardous 1,1a,3,3a,4,5,5,5a,5b,6-Decachloro--octahydro-1,2,4-metheno-2H-cyclobuta (cd) pentalen-2- one, chlorecone Extremely Hazardous 1,1-Dimethylhydrazine 57-14-7 Extremely Hazardous 1,2,3,4,10,10-Hexachloro-6,7-epoxy-1,4,4,4a,5,6,7,8,8a-octahydro-1,4-endo-endo-5,8- dimethanonaph-thalene Extremely Hazardous 1,2,3-Propanetriol, trinitrate P081 55-63-0 Acutely Hazardous 1,2,3-Propanetriol, trinitrate 55-63-0 Extremely Hazardous 1,2,4,5,6,7,8,8-Octachloro-4,7-methano-3a,4,7,7a-tetra- hydro- indane Extremely Hazardous 1,2-Benzenediol, 4-[1-hydroxy-2-(methylamino)ethyl]- 51-43-4 Extremely Hazardous 1,2-Benzenediol, 4-[1-hydroxy-2-(methylamino)ethyl]-, P042 51-43-4 Acutely Hazardous 1,2-Dibromo-3-chloropropane 96-12-8 Extremely Hazardous 1,2-Propylenimine P067 75-55-8 Acutely Hazardous 1,2-Propylenimine 75-55-8 Extremely Hazardous 1,3,4,5,6,7,8,8-Octachloro-1,3,3a,4,7,7a-hexahydro-4,7-methanoisobenzofuran Extremely Hazardous 1,3-Dithiolane-2-carboxaldehyde, 2,4-dimethyl-, O- [(methylamino)-carbonyl]oxime 26419-73-8 Extremely Hazardous 1,3-Dithiolane-2-carboxaldehyde, 2,4-dimethyl-, O- [(methylamino)-carbonyl]oxime.
    [Show full text]
  • Analysis of Carbamate and Organophosphate Pesticides in Animal Poisoning Cases by GC/MS
    Analysis of Carbamate and Organophosphate Pesticides in Animal Poisoning Cases by GC/MS Jessica M Greene, BS Barry Logan, PhD, Stephen Donovan, PhD, Karen Scott, PhD, Alana Balogh, BFA 03/02/17 1 Background 2 Africa • Pesticides are readily available in Africa for legitimate use • Pesticides are thus available for use as poisons • Conflicts between farmers and wildlife • Poachers attempting to hide illicit activities 3 The Poisonings Effect • Lions • Vultures • Elephants • Hyenas • Humans 4 Organophosphate & Carbamate Pesticides • Acetylcholinesterase inhibitors • CNS effects can be varied but poisoning ultimately will lead to muscle contractions followed by paralysis and death due to respiratory failure • Absorption occurs through all routes Figure 1: Organophosphate Figure 2: Carbamate Basic Structure Basic Structure 5 Aims • Develop and optimize a method for OP and carbamates • Create an extraction procedure for the pesticides • Receive authentic samples • Provide reliable and authoritative results to wildlife advocates in Africa 6 Method Development 7 Original Method 8 Finalization of Method GC/MS Parameters GC Agilent 7890A Column HP-4MS Ultra Inert Column Length 30 m Carrier Gas Hydrogen Injection Type/Volume Splitless/ 1 µL Inlet Temperature 250 ⁰C Oven Program 40 ⁰C for 1 minute 15 ⁰C/min to 170 ⁰C, hold for 5 minutes 25 ⁰C/min to 350 ⁰C, hold for 3 minutes Flow 1.1 mL/min MS Agilent 5975C MS Scan Range 35-500 amu 9 Test Mix on Final Method 10 Extraction Optimization 11 In-Field Extraction Add acetone to biological material and
    [Show full text]
  • Quantum Chemical Study of the Thermochemical Properties of Organophosphorous Compounds A
    QUANTUM CHEMICAL STUDY OF THE THERMOCHEMICAL PROPERTIES OF ORGANOPHOSPHOROUS COMPOUNDS A. Khalfa, M. Ferrari, R. Fournet, B. Sirjean, L. Verdier, Pierre-Alexandre Glaude To cite this version: A. Khalfa, M. Ferrari, R. Fournet, B. Sirjean, L. Verdier, et al.. QUANTUM CHEMICAL STUDY OF THE THERMOCHEMICAL PROPERTIES OF ORGANOPHOSPHOROUS COMPOUNDS. Journal of Physical Chemistry A, American Chemical Society, 2015, 119 (42), pp.10527-10539. 10.1021/acs.jpca.5b07071. hal-01241498 HAL Id: hal-01241498 https://hal.archives-ouvertes.fr/hal-01241498 Submitted on 10 Dec 2015 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. QUANTUM CHEMICAL STUDY OF THE THERMOCHEMICAL PROPERTIES OF ORGANOPHOSPHOROUS COMPOUNDS A. Khalfa, M. Ferrari1, R. Fournet1, B. Sirjean1, L. Verdier2, P.A. Glaude1 1Laboratoire Réactions et Génie des Procédés, Université de Lorraine, CNRS, 1 rue Grandville, BP 20451, 54001 NANCY Cedex, France, 2DGA Maîtrise NRBC, Site du Bouchet, 5 rue Lavoisier, BP n°3, 91710 Vert le Petit, France Abstract Organophosphorous compounds are involved in many toxic compounds such as fungicides, pesticides, or chemical warfare nerve agents. The understanding of the decomposition chemistry of these compounds in the environment is largely limited by the scarcity of thermochemical data.
    [Show full text]
  • Malathion Human Health and Ecological Risk Assessment Final Report
    SERA TR-052-02-02c Malathion Human Health and Ecological Risk Assessment Final Report Submitted to: Paul Mistretta, COR USDA/Forest Service, Southern Region 1720 Peachtree RD, NW Atlanta, Georgia 30309 USDA Forest Service Contract: AG-3187-C-06-0010 USDA Forest Order Number: AG-43ZP-D-06-0012 SERA Internal Task No. 52-02 Submitted by: Patrick R. Durkin Syracuse Environmental Research Associates, Inc. 5100 Highbridge St., 42C Fayetteville, New York 13066-0950 Fax: (315) 637-0445 E-Mail: [email protected] Home Page: www.sera-inc.com May 12, 2008 Table of Contents Table of Contents............................................................................................................................ ii List of Figures................................................................................................................................. v List of Tables ................................................................................................................................. vi List of Appendices ......................................................................................................................... vi List of Attachments........................................................................................................................ vi ACRONYMS, ABBREVIATIONS, AND SYMBOLS ............................................................... vii COMMON UNIT CONVERSIONS AND ABBREVIATIONS.................................................... x CONVERSION OF SCIENTIFIC NOTATION ..........................................................................
    [Show full text]
  • Table II. EPCRA Section 313 Chemical List for Reporting Year 2017 (Including Toxic Chemical Categories)
    Table II. EPCRA Section 313 Chemical List For Reporting Year 2017 (including Toxic Chemical Categories) Individually listed EPCRA Section 313 chemicals with CAS numbers are arranged alphabetically starting on page II-3. Following the alphabetical list, the EPCRA Section 313 chemicals are arranged in CAS number order. Covered chemical categories follow. Note: Chemicals may be added to or deleted from the list. The Emergency Planning and Community Right-to-Know Call Center or the TRI-Listed Chemicals website will provide up-to-date information on the status of these changes. See section B.3.c of the instructions for more information on the de minimis % limits listed below. There are no de minimis levels for PBT chemicals since the de minimis exemption is not available for these chemicals (an asterisk appears where a de minimis limit would otherwise appear in Table II). However, for purposes of the supplier notification requirement only, such limits are provided in Appendix C. Chemical Qualifiers Certain EPCRA Section 313 chemicals listed in Table II have parenthetic “qualifiers.” These qualifiers indicate that these EPCRA Section 313 chemicals are subject to the section 313 reporting requirements if manufactured, processed, or otherwise used in a specific form or when a certain activity is performed. An EPCRA Section 313 chemical that is listed without a qualifier is subject to reporting in all forms in which it is manufactured, processed, and otherwise used. The following chemicals are reportable only if they are manufactured, processed, or otherwise used in the specific form(s) listed below: Chemical/ Chemical Category CAS Number Qualifier Aluminum (fume or dust) 7429-90-5 Only if it is a fume or dust form.
    [Show full text]
  • Amending Annex II to Directives 76/895/EEC and 86/362/EEC
    20 . 5 . 88 Official Journal of the European Communities No L 126/53 COUNCIL DIRECTIVE of 16 May 1988 amending Annex II to Directives 76/895/EEC and 86/362/EEC relating to the fixing of maximum levels for pesticide residues in and on fruit and vegetables and cereals respectively (88/298/EEC) THE COUNCIL OF THE EUROPEAN COMMUNITIES, Having regard to the Treaty establishing the European Economic Community, Having regard to Council Directive 76/895/EEC of 23 November 1976 relating to the fixing of maximum levels for pesticide residues in and on fruit and vegetables 0), as last amended by Regulation (EEC) No 3768/85 (2), and in particular Article 5 thereof, Having regard to Council Directive 86/362/EEC of 24 July 1986 on the fixing of maximum levels for pesticide residues in and on cereals (3), and in particular Article 1 1 thereof, Having regard to the proposal from the Commission, Whereas, in the light of technical and scientific progress and of the requirements of public health and agriculture, it is necessary to amend the provisions, particularly the maximum levels, contained in Annex II to Directive 76/895/EEC relating to captafol, captan, chlorfenvinphos, dodine, fenitrothion, folpet, formothion and malathion ; Whereas, for the same reasons, it seems desirable to update Directive 76/895/EEC by adding provisions relating to further pesticides, residues of which may occur in and on fruit and vegetables, namely, ethion, ethylene dibromide, mevinphos, phosalone and 2, 4, 5-T, arid to update Directive 86/362/EEC by adding provisions relating to a further pesticide the residues of which may occur in cereals, namely, captafol, HAS ADOPTED THIS DIRECTIVE : Article 1 Annex II to Directive 76/895/EEC is hereby amended as follows : 1 .
    [Show full text]
  • Use the Decision Was Signed on the Same Day As the Completion of the OP Cumulative Assessment
    UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON D.C., 20460 OFFICE OF PREVENTION, PESTICIDES AND TOXIC SUBSTANCES MEMORANDUM DATE: July 31, 2006 SUBJECT: Finalization of Interim Reregistration Eligibility Decisions (IREDs) and Interim Tolerance Reassessment and Risk Management Decisions (TREDs) for the Organophosphate Pesticides, and Completion of the Tolerance Reassessment and Reregistration Eligibility Process for the Organophosphate Pesticides FROM: Debra Edwards, Director Special Review and Reregistration Division Office of Pesticide Programs TO: Jim Jones, Director Office of Pesticide Programs As you know, EPA has completed its assessment of the cumulative risks from the organophosphate (OP) class of pesticides as required by the Food Quality Protection Act of 1996. In addition, the individual OPs have also been subject to review through the individual- chemical review process. The Agency’s review of individual OPs has resulted in the issuance of Interim Reregistration Eligibility Decisions (IREDs) for 22 OPs, interim Tolerance Reassessment and Risk Management Decisions (TREDs) for 8 OPs, and a Reregistration Eligibility Decision (RED) for one OP, malathion.1 These 31 OPs are listed in Appendix A. EPA has concluded, after completing its assessment of the cumulative risks associated with exposures to all of the OPs, that: (1) the pesticides covered by the IREDs that were pending the results of the OP cumulative assessment (listed in Attachment A) are indeed eligible for reregistration; and 1 Malathion is included in the OP cumulative assessment. However, the Agency has issued a RED for malathion, rather than an IRED, because the decision was signed on the same day as the completion of the OP cumulative assessment.
    [Show full text]
  • SECRETARY HICKEL BANS USE of 16 PESTICIDES on ANY INTERIOR LANDS OR PROGRAMS -- June 18, 1970
    i DEPARTMENT of the INTERIOR news release OFFICE OF THE SECRETARY For Release Thursday, June 18, 1970 SECRETARYHICKEL BANS USE OF 16 PESTICIDES ON ANY INTERIOR LANDS OR PROGRAMS Secretary of the Interior Walter J. Hickel today announced a new policy flatly banning the use of 16 types of pesticides on any lands managed by the Department's bureaus and agencies, or in any program run by them. The Department administers approximately 70 percent of all federally owned lands. Included in this list of prohibited pesticides are such widely-known substances as DDT, Aldrin, 2, 4, 5,-T, Dieldrin, Endrin, Heptachlor, Lindane and Toxaphene. Also on the list of unconditionally banned items are Amitrol, arsenical compounds (inorganic), Azodrin, Bidrin, DDD (TDE), mercurial compounds, Strobane, and Thallium Sulfate. The Secretary pointed out that nearly all use of these pesticides has been banned on Interior Lands during recent years. The purpose of the new statement, he said, is to establish a policy for guidance of all Interior personnel. Another group of chemical pesticides, titled the Restricted List, are to be used only when non-chemical techniques have been considered and found inadequate, and when use can be limited to small-scale applications. Secretary Hickel emphasized that the use of any chemical pesticide by his agencies must be aimed at a specific pest problem, and involve minimum strength and minimum frequency of application. "We in the Interior Department-- the Nation's chief conservation agency have a special obligation to protect the environment for all the people,“’ Secretary Hickel said. "We are charged by law with responsibility for protecting interstate and coastal water quality, our fish and wildlife resources, the integrity of our national parks, public lands, and recreation areas," the Secretary continued.
    [Show full text]