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The WHO Recommended Classi cation of Pesticides by Hazard and Guidelines to Classi cation 2019

The WHO Recommended Classification of Pesticides by Hazard and Guidelines to Classification 2019 TheInternational Programme on Chemical Safety (IPCS) was established in 1980. The overall objectives of the IPCS are to establish the scientific basis for assessment of the risk to human health and the environment from exposure to chemicals, through international peer review processes, as a prerequisite for the promotion of chemical safety, and to provide technical assistance in strengthening national capacities for the sound management of chemicals.

This publication was developed in the IOMC context. The contents do not necessarily reflect the views or stated policies of individual IOMC Participating Organizations.

The Inter-Organization Programme for the Sound Management of Chemicals (IOMC) was established in 1995 following recommendations made by the 1992 UN Conference on Environment and Development to strengthen cooperation and increase international coordination in the field of chemical safety. The Participating Organizations are: FAO, ILO, UNDP, UNEP, UNIDO, UNITAR, WHO, World Bank and OECD. The purpose of the IOMC is to promote coordination of the policies and activities pursued by the Participating Organizations, jointly or separately, to achieve the sound management of chemicals in relation to human health and the environment.

WHO recommended classification of pesticides by hazard and guidelines to classification, 2019 edition

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The WHO Recommended Classification of Pesticides by Hazard was approved by the 28th World Health Assembly in 1975 and has since gained wide acceptance. When it was published in the WHO Chronicle, 29, 397-401 (1975), an annex, which was not part of the Classification, illustrated its use by listing examples of classification of some pesticidal active ingredients and their formulations. Later suggestions were made by Member States and pesticide registration authorities that further guidance should be given on the classification of individual pesticides. Guidelines were first issued in 1978, and have since been revised and reissued every few years.

Up until 2009 the original guidelines approved by the World Health Assembly in 1975 were followed without amendment. The 2009 version of the guidelines introduced revised criteria for classification for the WHO Hazard Classes to take into account The“ Globally Harmonized System of Classification and Labelling of Chemicals” (GHS) 1. The GHS was published with the intent to provide a globally-harmonized system to address classification of chemicals, labels, and safety data sheets. The GHS (with subsequent revisions) is now being widely used for the classification and labelling of chemicals worldwide.

The information provided in this publication can be used to support efforts to manage pesticides appropriately, in line with the WHO/FAO International Code of Conduct on Pesticide Management2. In particular, this publication can be used to define “highly hazardous pesticides” using the criteria developed by the Joint FAO/WHO Meeting on Pesticide Management3 (page 12).

The document is arranged as follows:

Part I: Overarching principles for the classification of pesticides as recommended by the World Health Assembly. These principles continue to apply, but the World Health Assembly Resolution envisaged that the classification criteria might need to be developed with time and increasing experience. The guide-points originally proposed in 1975 were aligned with corresponding Acute Toxicity Hazard Categories from the GHS.

Part II: Guidelines to Classification. Individual active ingredients are classified in a series of tables, according to the oral or dermal toxicity of the technical material. The tables are subject to review periodically. As has always been the case, the classification of some pesticides has been adjusted to take account of severe hazards to health other than acute toxicity.

The GHS Acute Toxicity Hazard Category for each pesticide is also presented. The GHS also contains provisions for classification according to carcinogenic, mutagenic or reproductive effects, or effects of long-term or repeated exposures. Many Member States have established and published GHS

1 See http://www.unece.org/trans/danger/publi/ghs/ghs_welcome_e.html. 2 See http://www.fao.org/3/I3604E/i3604e.pdf. 3 See http://apps.who.int/iris/bitstream/10665/205561/1/9789241510417_eng.pdf?ua=1.

The WHO Recommended Classification of Pesticides by Hazard and Guidelines to Classification 2019 1 classifications for these other end-points for pesticides and other chemicals under their jurisdiction. These classifications may be identified from online resources such as the OECD eChemPortal (echemportal.org).

The toxicity values are intended to be a guide only. Formulations should be separately classified using the methods set out on pages 4 (single technical product) and 8 (mixtures) and the table in Part I. To assist in the classification of formulations, an annex is provided giving numerical tables from which the classification may also be derived.

Comments on Part II of the document are welcome, together with proposals for new entries. These should be addressed to the International Programme on Chemical Safety, World Health Organization, 20 avenue Appia, 1211 Geneva 27, Switzerland, and should include supporting data on the compound being commented on or proposed.

This document is a revision of the document previously issued as ISBN 978 92 4 154796 3.

2 The WHO Recommended Classification of Pesticides by Hazard PART I: RECOMMENDED CLASSIFICATION OF PESTICIDES BY HAZARD

Extract from WHO Chronicle, 29: 397-401 (1975) In 1973, the WHO Executive Board asked the Director-General of WHO to take steps to develop a tentative classification of pesticides that would distinguish between the more and the less hazardous forms of each pesticide. A proposal for a WHO recommended classification of pesticides by hazard was accordingly prepared, taking into account the views of members of the WHO Expert Advisory Panel on Insecticides and other expert advisory panels with special competence and interest in pesticide technology, as well as the comments of WHO Member States and of two international agencies. This proposal was adopted by the Twenty-eighth World Health Assembly, which recommended the use of the classification by Member States, international agencies, and regional bodies.

The text below is reproduced from the Proposal4 which was adopted by the World Health Assembly in 1975.

The hazard referred to in this Recommendation is the acute risk to health (that is, the risk of single or multiple exposures over a relatively short period of time) that might be encountered accidentally by any person handling the product in accordance with the directions for handling by the manufacturer or in accordance with the rules laid down for storage and transportation by competent international bodies.

Any classification based on biological data can never be treated as final. In the assessment of biological data, honest differences of opinion are inevitable and most borderline cases can be reclassified in an adjacent class. Variability or inconsistency in toxicity data due to differences in susceptibility of test animals, or to experimental techniques and materials used can also result in differing assessments. The classification criteria are guide-points intended to supplement but never to substitute for special knowledge, sound clinical judgement or experience with a compound. Reappraisal might be necessary from time to time. Basis of classification

The classification distinguishes between the more and the less hazardous forms of each pesticide in that it is based on the toxicity of the technical compound and on its formulations. [In particular, allowance is made for the lesser hazards from solids as compared with liquids.]5

4 Official Record of the World Health Organization 1975, No.223, Part 1, p.12 5 Note: this distinction is not made in the GHS and no longer applies to the WHO Classification

PART I: RECOMMENDED CLASSIFICATION OF PESTICIDES BY HAZARD 3 The classification is based primarily on the acute oral and dermal toxicity to the rat since these determinations are standard procedures in toxicology. Where the dermal LD506 value of a compound is such that it would place it in a more restrictive class than the oral LD50 value would indicate, the compound will always be classified in the more restrictive class. Provision is made for the classification of a particular compound to be adjusted if, for any reason, the acute hazard to man differs from that indicated by LD50 assessments alone. Application of the criteria for classification

(a) Where it is shown that for a particular compound the rat is not the most suitable test animal (for example, if another species is conspicuously more sensitive or more closely resembles man in its reaction) then the classification of that compound should take this into account.

(b) In practice, the majority of classifications will be made on the acute oral LD50 value. However, dermal toxicity must always be considered since it has been found that, under most conditions of handling pesticides, a high proportion of the total exposure is dermal. Classification based on dermal data in a class indicating a great risk is necessary when the dermal LD50 values indicate greater hazard than oral LD50 values.

(c) If the active ingredient produces irreversible damage to vital organs, is highly volatile, is markedly cumulative in its effect, or is found after direct observations to be particularly hazardous or significantly allergenic to man, then adjustments to the classification can be made by classifying the compound in a class indicating a higher hazard. Alternatively, if it can be shown that the preparation is less toxic or hazardous than expected from consideration of the LD50 values of the ingredient or ingredients, or for any other reason, adjustments should be made by classifying the compound in a class indicating a lower hazard.

(d) In certain special cases the acute oral or dermal LD50 values of the compound or formulation should not be used as the main basis for classification. In such cases (for example, aerosol preparations, other special formulations and fumigants), more appropriate criteria should be used.

(e) It is highly desirable that, whenever practicable, toxicological data for each formulation to be classified should be available from the manufacturer. However, if such data are not obtainable, then the classification may be based on proportionate calculations from the LD50 values of the technical ingredient or ingredients, according to the following formula:

LD50 active ingredient × 100

Percentage of active ingredient in formulation

If the formulation contains more than one ingredient (including solvents, wetting agents, etc.) of significant toxicity-enhancing properties, then the classification should correspond to the toxicity of the mixed ingredients.

6 The LD50 value is a statistical estimate of the number of mg of toxicant per kg of bodyweight required to kill 50% of a large population of test animals.

4 The WHO Recommended Classification of Pesticides by Hazard (f) With a few exceptions, pesticides have low volatility and therefore no criteria are at present set out for volatility in this Recommendation. The inclusion of such criteria is unlikely to affect the classification of pesticides by hazard except in the case of volatile fumigants used in agriculture and food storage. On the other hand, when the criteria are applied to pesticide formulations based on solvents or to other chemicals, account must be taken of volatility and consequent inhalation toxicity. [Further information on the inhalation toxicity of pesticides used as fumigants is now presented in Table 8.] Effects of classification on labeling7

While no specific symbols to identify classes are included in the Recommendation, the following are the general implications of the classification as regards labelling.

The aim should be uniformity in the statement on the nature of the risk (by phrase and/or symbol) on the label of the product, irrespective of the country of origin or use. Labels of products classified in classes Ia and Ib should bear a symbol indicating a high degree of hazard (usually a type of skull and crossbones) and a signal word or phrase, e.g. POISON or TOXIC. The presentation of the symbol and word or phrase, in terms of colour, size and shape should ensure that they are given sufficient prominence on the label.

The text should be in the local language and for all formulations should include the approved name of the active ingredient or ingredients, the method of use, and precautions to be taken in use. For classes Ia and Ib, symptoms and immediate treatment of poisoning should also be included.

The detailed precautions necessary for the use of a pesticide depend on the nature of the formulation and the pattern of use and are best decided by a pesticide registration authority when accepting a commercial label.

There are international agreements on symbols to denote hazards from materials which are inflammable, corrosive, explosive, etc., and these should be consulted and used where appropriate.

7 See WHO/FAO International Code of Conduct on Pesticide Management, WHO/FAO (2014), available at http://www.fao.org/3/ I3604E/i3604e.pdf; also Guidelines on Good Labelling Practice for Pesticides, WHO/FAO (2015), available at http://apps.who.int/ iris/bitstream/10665/195650/1/9789241509688_eng.pdf?ua=1.

PART I: RECOMMENDED CLASSIFICATION OF PESTICIDES BY HAZARD 5 Revised criteria for classification (in use since 2009 update)

The table showing the Recommended Criteria for Classification from the original World Health Assembly Proposal is not shown because it is no longer used. WHO now uses the Acute Toxicity Hazard Categories from the GHS8 as the starting point for classification. This change is consistent with the 1975 World Health Assembly Resolution which envisaged that the WHO Classification would be further developed with time in consultation with countries, international agencies and regional bodies. The GHS meets this requirement as a classification system with global acceptance following extensive international consultation.

LD50 for the rat (mg/kg body weight) Class Oral Dermal Ia Extremely hazardous < 5 < 50 Ib Highly hazardous 5–50 50–200 II Moderately hazardous 50–2000 200–2000 III Slightly hazardous Over 2000 Over 2000 U Unlikely to present acute hazard 5000 or higher

Details of how the WHO Classification has been aligned with the GHS Acute Toxicity Hazard Categories are presented in Part II.

8 See http://www.unece.org/trans/danger/publi/ghs/ghs_welcome_e.html. The categories for oral and dermal routes are used.

6 The WHO Recommended Classification of Pesticides by Hazard PART II: GUIDELINES TO CLASSIFICATION OF 28 march 2020 Note capitalization, tab, PESTICIDES BY HAZARD removal of extra Table 7, Table 8 full title restore, The main section of the guidelines consists of five tables preceded by notes on their use. In the tables, active ingredients (technical grade) have been classified as follows: and Index title customizing

Table 1. EXTREMELY HAZARDOUS (Class Ia) technical grade active ingredients in pesticides 21 Table 2. HIGHLY HAZARDOUS (Class Ib) technical grade active ingredients in pesticides 23 Table 3. MODERATELY HAZARDOUS (Class II) technical grade active ingredients in pesticides 27 Table 4. SLIGHTLY HAZARDOUS (Class III) technical grade active ingredients in pesticides 41 Table 5. Technical grade active ingredients of pesticides unlikely to present acute hazard in normal use 49

The tables are arranged in alphabetical order.

In addition, the following tables show the details stated:

Table 6. Active ingredients believed to be obsolete or discontinued for use as pesticides 59 Table 7. Pesticides subject to the Rotterdam Convention 65 Table 8. Gaseous or volatile fumigants not classified under the WHO Recommended Classification of Pesticides by Hazard 67

ANNEX How to find the hazard class of a formulation 69 INDEX by CAS number 72 by name of active ingredient 81

PART II: GUIDELINES TO CLASSIFICATION OF PESTICIDES BY HAZARD 7 NOTES ON THE USE OF THE TABLES IN CLASSIFICATION

The final classification of any product is intended to be by formulation

The classification given in the tables below is of active ingredients, and only forms the starting point for the final classification of an actual formulation. It is by far preferable that the final classification of a formulation should be based on toxicity data obtained on that formulation by the manufacturer: the criteria set out in the table of the Classification in Part I are then applied to this first-hand data. Only if this is not available should the formula be used, as shown in Part I on page 4 to extrapolate the LD50 of the formulation from that of the technical product. In this event, the single oral or dermal value of the LD50 given in the tables below should be used in the formula.. See also the Annex on page 69.

The following important points should be noted.

1. While the classification deals only with the acute risk to health, evaluations of other effects, including cancer, have been completed for many compounds for registration purposes. Where other effects have been shown to occur in man, these are noted in the ‘Remarks’ column and may have in some cases resulted in an adjusted classification.

2. Wherever possible, the data are listed under internationally approved common names, or if such names are not at present available, under nationally approved names. Some other common names appear in the alphabetic index on pages 81–92. Trade names are not given since there are many of these.

3. A list of references that may be used for the identification of pesticides is given at the end of these introductory notes, and the manufacturer should always assist by specifying any existing approved or common names for his product.

4. It is not possible to include classification of mixtures of pesticides in the guidelines: very many of these are marketed with varying concentrations of active constituents. There are three possible approaches to the classification of mixtures – in order of preference: (a) require the formulator to obtain reliable acute oral and dermal toxicity data for rats on the actual mixture as marketed: or (b) classify the formulation according to the most hazardous constituent of the mixture as if that constituent was present in the same concentration as the total concentration of all active constituents: or (c) apply the formula:

Ca Ca Cb Cb Cz Cz 100100 + + + + ≡ ≡ Ta Ta Tb Tb Tz Tz Tm Tm

Where C = the % concentrations of constituent A, B ... Z in the mixture T = the oral LD50 values of constituents A, B ... Z

Tm = the oral LD50 value of the mixture.

8 The WHO Recommended Classification of Pesticides by Hazard The formula can also be used for dermal toxicities provided that this information is available on the same species for all constituents. The use of this formula does not take into account any potentiation or protective phenomena.

5. In the tables below, single figures have been given as LD50 values for classification purposes, using the route as described in the table. Where several LD50 values have been published, the lowest deemed reliable is used. Where a sex difference occurs in LD50 values, the value for the more sensitive sex is used. A number of adjustments to Classification have been made in respect of some pesticides and these are explained. A borderline case has been classified in the more or less hazardous class after consideration of its toxicology and use experience.

6. In the former WHO Classification scheme pesticides were classified on the basis of the physical state of the technical product. A distinction between liquids and solids is no longer made.

7. In Table 5, a number of pesticides are listed as unlikely to present any acute hazard in normal use. The WHO classification is open-ended but it is clear that there must be a point at which the acute hazard posed by the use of these compounds is so low as to be negligible provided that the precautions are taken that should be used in dealing with any chemical. In compiling this table, it has been assumed that this point is an LD50 of 5000 mg/kg bw or greater (in line with the upper limit for classification in the GHS). However, it should not be overlooked that in formulations of these technical products, solvents or vehicles may present a greater hazard than the actual pesticide and therefore classification of a formulation in one of the higher hazard classes may be necessary.

8. The WHO Classification is not limited to chemical pesticides. Biological pesticides can also be included if a suitable evaluation is available (Bacillus thuringiensis is included based on Environmental Health Criteria Document 217).

9. The toxicity data for pyrethroids is highly variable according to isomer ratios, the vehicle used for oral administration, and the husbandry of the test animals e.g. fasting prior to dosing. The variability is reflected in the prefix ‘c’ before 50LD values. The single LD50 value chosen for classification purposes is generally based on administration in corn oil and can be much lower than that in aqueous solutions. This underlines the need for classification by formulation if the classification is to reflect true hazard.

PART II: GUIDELINES TO CLASSIFICATION OF PESTICIDES BY HAZARD 9 ENTRIES AND ABBREVIATIONS USED IN THE TABLES

New information since the previous edition is indicated by italics.

Column 1: Common name. [ISO] denotes common name of the active ingredient approved by the International Organization for Standardization. Such names are, when available, preferred by WHO to all other common names. However, attention is drawn to the fact that some of these names may not be acceptable for national use in some countries. If the letters ISO appear within parentheses (ISO), this indicates that ISO has standardized (or is in the process of standardizing) the name of the base, but not the name of the derivative listed in column 1. For example, fentin acetate (ISO) indicates that fentin is an ISO name, but fentin acetate is not. ISO* denotes pending ISO approval of the name. C denotes chemical, trivial, or other common name.

Column 2: CAS Registry number: The number for the chemical, not those for e.g. different esters or salts are given.

Column 3: UN number refers to the UN Recommendations on the transport of dangerous goods, Eleventh revision (1999), and subsequent revisions. Few active ingredients in Table 5 have UN numbers. The UN number refers only to the active ingredient; formulations are likely to have different numbers, since the ingredient may, for example, be dissolved in a solvent – and liquid products have different UN numbers, which depends on their flammability.

Column 4: Chemical type. Only a limited number of chemical types are shown. Most have some significance in the sense that they may have a common antidote, or may be confused in the nomenclature with other chemical types e.g. thiocarbamates are not cholinesterase inhibitors and do not have the same effects as carbamates. Chemical type is also a determinant of the UN numbering system. These chemical classifications are included only for convenience, and do not represent a recommendation on the part of the World Health Organization as to the way in which the pesticides should be classified. It should, furthermore, be understood that some pesticides may fall into more than one type.

AS Arsenic compound OP Organophosphorus compound BP Bipyridylium derivative OT Organotin compound C Carbamate PAA Phenoxyacetic acid derivative CO Coumarin derivative PZ Pyrazole CU Copper compound PY Pyrethroid HG Mercury compound T Triazine derivative NP Nitrophenol derivative TC Thiocarbamate OC Organochlorine compound

10 The WHO Recommended Classification of Pesticides by Hazard Column 5: Physical state. Refers only to the active ingredient. L denotes liquid, including solids with a melting point below 50°C; oil denotes oily liquids and S solids, including waxes. The physical state may affect the exposure potential, and thus the absorbed amount of the chemical, and was taken into account when determining classification under the previous scheme.

Column 6: Main use. In most cases only a single use is given. This is only for identification purposes and does not exclude other uses.

AC acaricide M molluscicide AP aphicide MT miticide B bacteriostat (soil) N nematocide FM fumigant O other use for plant pathogens F fungicide, other than for seed treatment PGR plant growth regulator FST fungicide, for seed treatment R rodenticide H herbicide RP repellant I insecticide -S applied to soil: not used with herbicides or IGR insect growth regulator plant growth regulators Ix ixodicide (for tick control) SY synergist L larvicide

Column 7: GHS: This column indicates the classification of the pesticide according toThe “ Globally Harmonized System of Classification and Labelling of Chemicals” (GHS)9. The value shown in the column is the Acute Toxic Hazard Category according to the GHS criteria, which in turn is derived from the acute toxicity estimate value for the substance. In the majority of cases the acute toxicity estimate will be the experimentally-derived LD50 value for oral exposure. For full details of classification according to GHS the official publication of the GHS should be consulted.

The former WHO Classification scheme used prior to 2009 applied different criteria to liquids and solids, but the GHS does not make a similar distinction and applies the same criteria. The GHS cut- off values for Category 2 and Category 3 are lower than the values which applied to liquids under the pre-2009 WHO scheme, such that some liquids allocated to Class Ib would be placed in the lower GHS Category 3 (specifically pesticides with oral LD50 values in the range 50–200 mg/kg bw). In aligning the WHO scheme with the GHS criteria there was no intention to “lower” the classification of pesticides previously considered to be “Highly hazardous”. Therefore, the classification of this limited number of liquid pesticides has been adjusted such that they remain in Class Ib. The criteria for the WHO classification scheme now being used are shown in Part I page( 6).

Column 8: LD50. The LD50 value is a statistical estimate of the number of mg of toxicant per kg of body weight required to kill 50% of a large population of test animals: the rat is used unless otherwise stated. Usually a single value, but sometimes a range is given. “c” preceding the value indicates that it is a value within a wider than usual range, adopted for classification purposes. When several different values are reported in the literature, the lowest is reported and used as the basis of classification, unless there are clear indications that a higher value is more reliable. Oral route values are used unless the dermal route values place the compound in a more hazardous class, or unless the dermal

9 See http://www.unece.org/trans/danger/publi/ghs/ghs_welcome_e.html. The categories for oral and dermal routes are used

ENTRIES AND ABBREVIATIONS USED IN THE TABLES 11 values are significantly lower than the oral values, although in the same class. Dermal LD50 values are indicated with the letter D.

Column 9: Remarks. This column is used to indicate cases in which the classification of a technical product has been adjusted (i.e., the oral LD50 value is not directly used as the basis of classification); Major irritant properties may also be noted although they do not affect the classification. Sources of further information may also be given here: EHC denotes an Environmental Health Criteria monograph, HSG a Health and Safety Guide, IARC refers to IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, ICSC an International Chemical Safety Card, JMPR an evaluation by the Joint FAO/WHO Meeting on Pesticide Residues (the year of evaluation is shown) and JECFA an evaluation by the Joint FAO/WHO Expert Committee on Food Additives. These publications can be found on the INCHEM website maintain by WHO (www.inchem.org). Further information on chemicals from WHO can be found on the IPCS web site (http://www.who.int/ipcs/).

Definition of Highly Hazardous Pesticides

The Joint FAO/WHO Meeting on Pesticide Management recommended10 that highly hazardous pesticides should be defined as having one or more of the following characteristics: • Criterion 1: Pesticide formulations that meet the criteria of classes Ia or Ib of the WHO Recommended Classification of Pesticides by Hazard; or • Criterion 2: Pesticide active ingredients and their formulations that meet the criteria of carcinogenicity Categories 1A and 1B of the Globally Harmonized System of Classification and Labelling of Chemicals (GHS); or • Criterion 3: Pesticide active ingredients and their formulations that meet the criteria of mutagenicity Categories 1A and 1B of the Globally Harmonized System of Classification and Labelling of Chemicals (GHS); or • Criterion 4: Pesticide active ingredients and their formulations that meet the criteria of reproductive toxicity Categories 1A and 1B of the Globally Harmonized System of Classification and Labelling of Chemicals (GHS); or • Criterion 5: Pesticide active ingredients listed by the Stockholm Convention in its Annexes A and B, and those meeting all the criteria in paragraph 1 of Annex D of the Convention; or • Criterion 6: Pesticide active ingredients and formulations listed by the Rotterdam Convention in its Annex III; or • Criterion 7: Pesticides listed under the Montreal Protocol; or • Criterion 8: Pesticide active ingredients and formulations that have shown a high incidence of severe or irreversible adverse effects on human health or the environment.

10 See http://apps.who.int/iris/bitstream/10665/205561/1/9789241510417_eng.pdf?ua=1

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REFERENCES 13 Environmental Health Criteria 45 Campechlor, Geneva, International Programme on Chemical Safety, 66 pp. 1984. Environmental Health Criteria 63 Organophosphorus Insecticides, Geneva, International Programme on Chemical Safety, 181 pp. 1986. Environmental Health Criteria 64 Carbamate Pesticides, Geneva, International Programme on Chemical Safety, 136 pp. 1986. Environmental Health Criteria 66 Kelevan, Geneva, International Programme on Chemical Safety, 32 pp. 1984. Environmental Health Criteria 67 Tetradifon, Geneva, International Programme on Chemical Safety, 47 pp. 1986. Environmental Health Criteria 71 Pentachlorophenol, Geneva, International Programme on Chemical Safety, 236 pp. 1987. Environmental Health Criteria 73 Phosphine and Selected Metal Phosphides, Geneva, International Programme on Chemical Safety, 100 pp. 1988. Environmental Health Criteria 76 Thiocarbamate Pesticides, Geneva, International Programme on Chemical Safety, 49 pp. 1988. Environmental Health Criteria 78 Dithiocarbamate Pesticides, Ethylenethiourea, and propylenethiourea, Geneva, International Programme on Chemical Safety, 140 pp. 1988. Environmental Health Criteria 79 Dichlorvos, Geneva, International Programme on Chemical Safety, 157 pp. 1989. Environmental Health Criteria 82 Cypermethrin, Geneva, International Programme on Chemical Safety, 154 pp. 1989. Environmental Health Criteria 83 DDT and its Derivatives – Environmental Aspects, Geneva, International Programme on Chemical Safety, 98 pp. 1989. Environmental Health Criteria 84 2,4-Dichlorphenoxyacetic Acid – Environmental Aspects, Geneva, International Programme on Chemical Safety, 92 pp. 1989. Environmental Health Criteria 87 Allethrins, Geneva, International Programme on Chemical Safety, 75 pp. 1989. Environmental Health Criteria 90 Dimethoate, Geneva, International Programme on Chemical Safety, 85 pp. 1989. Environmental Health Criteria 92 Resmethrins; Geneva, International Programme on Chemical Safety, 79 pp. 1989. Environmental Health Criteria 94 Permethrin; Geneva, International Programme on Chemical Safety, 125 pp. 1990. Environmental Health Criteria 95 Fenvalerate; Geneva, International Programme on Chemical Safety, 121 pp. 1990. Environmental Health Criteria 96 d-Phenothrin; Geneva, International Programme on Chemical Safety, 64 pp. 1990. Environmental Health Criteria 97 Deltamethrin; Geneva, International Programme on Chemical Safety, 133 pp. 1990. Environmental Health Criteria 98 Tetramethrin; Geneva, International Programme on Chemical Safety, 69 pp. 1990. Environmental Health Criteria 99 Cyhalothrin; Geneva, International Programme on Chemical Safety, 106 pp. 1990. Environmental Health Criteria 121; Aldicarb; Geneva, International Programme on Chemical Safety, 130 pp. 1991. Environmental Health Criteria 123 Alpha- and Beta Hexachlorocyclohexanes, Geneva, International Programme on Chemical Safety, 170 pp. 1992. Environmental Health Criteria 124 Lindane; Geneva, International Programme on Chemical Safety, 208 pp. 1991. Environmental Health Criteria 132 Trichlorfon; Geneva, International Programme on Chemical Safety, 162 pp. 1992. Environmental Health Criteria 133 Fenitrothion; Geneva, International Programme on Chemical Safety, 184 pp. 1992. Environmental Health Criteria 142 Alpha-cypermethrin; Geneva, International Programme on Chemical Safety, 112 pp. 1992. Environmental Health Criteria 145 Methyl Parathion; Geneva, International Programme on Chemical Safety, 244 pp. 1993. Environmental Health Criteria 147 Propachlor, Geneva, International Programme on Chemical Safety, 110 pp. 1993. Environmental Health Criteria 148 Benomyl; Geneva, International Programme on Chemical Safety, 135 pp. 1993. Environmental Health Criteria 149 Carbendazim; Geneva, International Programme on Chemical Safety, 132 pp. 1993. Environmental Health Criteria 153 Carbaryl; Geneva, International Programme on Chemical Safety, 358 pp. 1993.

14 The WHO Recommended Classification of Pesticides by Hazard Environmental Health Criteria 158 Amitrole; Geneva, International Programme on Chemical Safety, 107 pp. 1994. Environmental Health Criteria 159 Glyphosate; Geneva, International Programme on Chemical Safety, 177 pp. 1994. Environmental Health Criteria 166 Methyl bromide; Geneva, International Programme on Chemical Safety, 324 pp. 1995. Environmental Health Criteria 175 Anticoagulant Rodenticides; Geneva, International Programme on Chemical Safety, 121 pp. 1995. Environmental Health Criteria 176 1,2-dichloroethane (ethylene dichloride); (2nd edition), Geneva, International Programme on Chemical Safety, 148 pp. 1995. Environmental Health Criteria 177 1,2-dibromoethane (ethylene dibromide); Geneva, International Programme on Chemical Safety, 146 pp. 1996. Environmental Health Criteria 178 Methomyl; Geneva, International Programme on Chemical Safety, 150 pp. 1996. Environmental Health Criteria 182 Thallium, Geneva, International Programme on Chemical Safety, 274 pp. 1996. Environmental Health Criteria 183 Chlorothalonil, Geneva, International Programme on Chemical Safety, 145 pp. 1996. Environmental Health Criteria 184 Diflubenzuron, Geneva, International Programme on Chemical Safety, 164 pp. 1996. Environmental Health Criteria 195 Hexachlorobenzene, Geneva, International Programme on Chemical Safety, 160 pp. 1997. Environmental Health Criteria 198 Diazinon, Geneva, International Programme on Chemical Safety, 140 pp. 1998 Environmental Health Criteria 200 Copper, Geneva, International Programme on Chemical Safety, 360 pp. 1998. Environmental Health Criteria 217 Bacillus thuringiensis, Geneva, International Programme on Chemical Safety, 105 pp. 1999. Environmental Health Criteria 220 Dinitro-ortho-cresol, Geneva, International Programme on Chemical Safety, 87 pp. 2000. Environmental Health Criteria 224 Arsenic and arsenic compounds (Second edition), Geneva, International Programme on Chemical Safety, 521 pp. 2001. FAO (1985), Guidelines on good labelling practice for pesticides, Rome, Food and Agriculture Organization of the United Nations, 36 pp. FAO (1990), International Code of Conduct on the Distribution and Use of Pesticides: Rome, Food and Agriculture Organization of the United Nations, 34 pp. HSGs. Health and Safety Guides, IPCS, Geneva, World Health Organization. See http://www.who.int/ipcs/publications/hsg/en/ index.html IARC 4. IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man Volume 4 Some Aromatic Amines, Hydrazine and related Substances, N-nitroso compounds and miscellaneous alkylating agents. Lyon, International Agency for Research on Cancer, 1974 IARC 5. IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man Volume 5 Some Organochlorine Pesticides. Lyon, International Agency for Research on Cancer, 1974 IARC 7. IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man Volume 7 Some Anti-thyroid and Related Substances, Nitrofurans and Industrial Chemicals. Lyon, International Agency for Research on Cancer, 1974 IARC 12. IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man Volume 12 Some Carbamates, Thiocarbamates and Carbazides. Lyon, International Agency for Research on Cancer, 1976 IARC 20. IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans Volume 20 Some Halogenated Hydrocarbons. Lyon, International Agency for Research on Cancer, 1979 IARC 30. IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans Volume 30 Miscellaneous Pesticides. Lyon, International Agency for Research on Cancer, 1983 IARC 41. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans Volume 41 Some Halogenated Hydrocarbons and Pesticide Exposures. Lyon, International Agency for Research on Cancer, 1986.

REFERENCES 15 IARC 53. Monographs on the Evaluation of Carcinogenic Risks to Humans Volume 53 Occupational Exposures in Insecticide Application and some Pesticides. Lyon, International Agency for Research on Cancer, 1991. IARC 60. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans Volume 60 Some Industrial Chemicals. Lyon, International Agency for Research on Cancer, 1994 IARC 62. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans Volume 6 Wood dust and formaldehyde. Lyon, International Agency for Research on Cancer, 1995. IARC 63. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans Volume 63 Dry cleaning , Some Chlorinated Solvents and Other Industrial Chemicals. Lyon, International Agency for Research on Cancer, 1995. IARC 71. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans Volume 71 Re-evaluatio of some organic chemicals, hydrazine and hydrogen peroxide, Parts I-III1. Lyon, International Agency for Research on Cancer, 1999. IARC 73. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans Volume 73 some chemicals taht cause tumours of the kidney or urinary bladder in rodents and some other substances. Lyon, International Agency for Research on Cancer, 1999. IARC 79. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans Volume 79 some thyrotropic agents. Lyon, International Agency for Research on Cancer, 2001. IARC 82. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans Volume 82 Some Traditional Herbal Medicines, Some Mycotoxins, Naphthalene and Styrene. Lyon, International Agency for Research on Cancer, 2002 IARC 84. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans Volume 84 some drinking water disinfectants and contaminants, including arsenic. Lyon, International Agency for Research on Cancer, 2004. IARC 100F. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans Volume 100F Chemical Agents and Related Occupations. Lyon, International Agency for Research on Cancer, 2012 IARC 101. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans Volume 101 Some Chemicals Present in Industrial and Consumer Products, Food and Drinking-water. Lyon, International Agency for Research on Cancer, 2013 IARC 112. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans Volume 112 Some Organophosphate Insecticides and Herbicides. Lyon, International Agency for Research on Cancer, 2017 IARC 113. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans Volume 113 DDT, Lindane, and 2,4-D. Lyon, International Agency for Research on Cancer, 2018 IARC 117. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans Volume 117 Pentachlorophenol and Some Related Compounds. Lyon, International Agency for Research on Cancer, 2019 IARC Suppl 7. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans Voverall evaluations of carcinogenicity: An updating of IARC Monographs volumes 1 to 42. Lyon, International Agency for Research on Cancer, 1987. International Organization for Standardization (1981) Pesticides and other agrochemicals – common names, Geneva (ISO 1750). (Copies available only from national standards institutes). ICSCs. International Chemical Safety Cards, IPCS, Geneva, World Health Organization. See http://www.ilo.org/public/english/ protection/safework/cis/products/icsc/index.htm JECFA (1996) Toxicological evaluation of certain veterinary drug residues in food prepared by the forty-seventh meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA), WHO food additives series 38, Geneva, World Health Organization. JECFA (1997) Toxicological evaluation of vertain veterinary drug residues in food prepared by the forty-eighth meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA), WHO food additives series 39, Geneva, World Health Organization. JECFA (2000a) Toxicological evaluation of vertain veterinary drug residues in food prepared by the fifty-second meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA), WHO food additives series 43, Geneva, World Health Organization. JECFA (2000b) Toxicological evaluation of vertain veterinary drug residues in food prepared by the fifty-fourth meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA), WHO food additives series 45, Geneva, World Health Organization.

16 The WHO Recommended Classification of Pesticides by Hazard JECFA (2002) Toxicological evaluation of vertain veterinary drug residues in food prepared by the fifty-eighth meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA), WHO food additives series 49, Geneva, World Health Organization. JECFA (2003) Toxicological evaluation of vertain veterinary drug residues in food prepared by the sixtieth meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA), WHO food additives series 51, Geneva, World Health Organization. JMPR – table entries are presented by the year of evaluation – see separate references. JMPS (2010) FAO specifications and evaluations for agricultural pesticides - Fenoxaprop-p-ethyl. 9th Joint FAO/WHO Meeting on Pesticide Specifications (JMPS), 7 June 2010. Rome, Food and Agriculture Organization of the United Nations.http://www. fao.org/fileadmin/templates/agphome/documents/Pests_Pesticides/Specs/Fenoxaprop2010.pdf JMPS (2013) FAO specifications and evaluations for agricultural pesticides - Flazasulfuron. 12th Joint FAO/WHO Meeting on Pesticide Specifications (JMPS), 10 June 2013. Rome, Food and Agriculture Organization of the United Nations. http://www.fao. org/fileadmin/templates/agphome/documents/Pests_Pesticides/Specs/Flazasulfuron2013.pdf JMPS (2019) FAO specifications and evaluations for agricultural pesticides - Zeta-cypermethrin. 18th Joint FAO/WHO Meeting on Pesticide Specifications (JMPS), 17 June 2019. Rome, Food and Agriculture Organization of the United Nations.http://www. fao.org/3/ca5795en/ca5795en.pdf Tomlin C, ed. The Pesticide Manual, A World Compendium (10th edition 1994). British Crop Protection Council, Thornton Heath, United Kingdom. Tomlin C, ed. The Pesticide Manual, A World Compendium (11th edition 1997). British Crop Protection Council, Farnham, United Kingdom. Tomlin C, ed. The Pesticide Manual, A World Compendium (13th edition 2003). British Crop Protection Council, Farnham, United Kingdom. United Nations (1999) Recommendations on the transport of dangerous goods. Model regulations. Eleventh revised edition. United Nations, New York and Geneva. 573 pp. United States Environmental Protection Agency (1998) Pesticide Fact Sheet – Imiprothrin, March, 1998. https://www3.epa. gov/pesticides/chem_search/reg_actions/registration/fs_PC-004006_01-Mar-98.pdf United States Environmental Protection Agency (2006) Pesticide Fact Sheet – Metofluthrin, September, 2006.https://www3. epa.gov/pesticides/chem_search/reg_actions/registration/fs_PC-109709_01-Sep-06.pdf United States Environmental Protection Agency (2008) Pesticide Fact Sheet – Pyroxsulam, February, 2008. https://www3. epa.gov/pesticides/chem_search/reg_actions/registration/fs_PC-108702_27-Feb-08.pdf United States Environmental Protection Agency (2010) Pesticide Fact Sheet – Dimethyl disulfide, 9 July, 2010. https://www3. epa.gov/pesticides/chem_search/reg_actions/pending/fs_PC-029088_09-Jul-10.pdf United States Environmental Protection Agency (2011) Pesticide Fact Sheet – Amisulbrom, 16 September, 2010. https:// www3.epa.gov/pesticides/chem_search/reg_actions/pending/fs_PC-016330_16-sep-11.pdf WHO (1979), Environmental Health Criteria 9; DDT and its Derivatives, Geneva, World Health Organization, 194 pp. WHO (1980), Environmental health Criteria 15; Tin and Organotin Compounds, Geneva, World Health Organization, 109 pp. Worthing, C.R., Hance,R.J., eds. (1991), The Pesticide Manual. A World Compendium (9th Edition). British Crop Protection Council, Surrey, United Kingdom, 1141 pp

REFERENCES 17 JMPR evaluations by year

Year of evaluation Reference 1965 JMPR (1965a) Evaluation of the toxicity of pesticide residues in food. FAO Meeting Report, No. PL/1965/10/1; WHO/Food Add./27.65. 1965 JMPR (1965b) Evaluation of the hazards to consumers resulting from the use of fumigants in the protection of food. FAO Meeting Report, No. PL/1965/10/2; WHO/Food Add./28.65. 1967 JMPR (1967) Evaluation of some pesticide residues in food. FAO/PL:CP/15; WHO/Food Add./67.32. 1969 JMPR (1969) 1968 Evaluation of some pesticide residues in food. FAO/PL:1968/M/9/1; WHO/Food Add./69.35. 1973 JMPR (1974) 1973 Evaluations of some pesticide residues in food. FAO/AGP/1973/M/9/1; WHO Pesticide Residues Series, No. 3. 1977 JMPR (1978) Pesticide residues in food: 1977 evaluations. FAO Plant Production and Protection Paper 10 Sup. 1978 JMPR (1979) Pesticide residues in food: 1978 evaluations. FAO Plant Production and Protection Paper 15 Sup. 1979 JMPR (1980) Pesticide residues in food: 1979 evaluations. FAO Plant Production and Protection Paper 20 Sup. 1981 JMPR (1982) Pesticide residues in food:1981 evaluations. FAO Plant Production and Protection Paper 42. 1982 JMPR (1983) Pesticide residues in food: 1982 evaluations. FAO Plant Production and Protection Paper 49. 1983 JMPR (1985) Pesticide residues in food: 1983 evaluations. FAO Plant Production and Protection Paper 61. 1984 JMPR (1985) Pesticide residues in food – 1984. Report of the Joint Meeting on Pesticide Residues. FAO Plant Production and Protection Paper 62. 1985 JMPR (1986) Pesticide residues in food – 1985 evaluations. Part II – Toxicology. FAO Plant Production and Protection Paper 72/2. 1986 JMPR (1987) Pesticide residues in food – 1986 evaluations. Part II – Toxicology. FAO Plant Production and Protection Paper 78/2. 1987 JMPR (1988) Pesticide residues in food – 1987 evaluations. Part II – Toxicology. FAO Plant Production and Protection Paper 86/2. 1988 JMPR (1989) Pesticide residues in food – 1988 evaluations. Part II – Toxicology. FAO Plant Production and Protection Paper 93/2. 1989 JMPR (1990) Pesticide residues in food – 1989 evaluations. Part II – Toxicology. FAO Plant Production and Protection Paper 100/2. 1990 JMPR (1991) Pesticide residues in food – 1990 evaluations. Part II – Toxicology. World Health Organization (WHO/PCS/91.47). 1991 JMPR (1992) Pesticide residues in food – 1991 evaluations. Part II – Toxicology. World Health Organization (WHO/PCS/92.52). 1992 JMPR (1993) Pesticide residues in food – 1992 evaluations. Part II – Toxicology. World Health Organization (WHO/PCS/93.34).

18 The WHO Recommended Classification of Pesticides by Hazard 1993 JMPR (1994) Pesticide residues in food – 1993 evaluations. Part II – Toxicology. World Health Organization (WHO/PCS/94.4). 1994 JMPR (1995) Pesticide residues in food – 1994 evaluations. Part II – Toxicology. World Health Organization (WHO/PCS/95.2). 1995 JMPR (1996) Pesticide residues in food – 1995 evaluations. Part II – Toxicological and Environmental. Geneva, World Health Organization (WHO/PCS/96.48). 1996 JMPR (1997) Pesticide residues in food – 1996 evaluations. Part II – Toxicological and Environmental. Geneva, World Health Organization (WHO/PCS/97.1). 1997 JMPR (1998) Pesticide residues in food – 1997 evaluations. Part II – Toxicological and Environmental. Geneva, World Health Organization (WHO/PCS/98.6). 1998 JMPR (1999) Pesticide residues in food – 1998 evaluations. Part II – Toxicological. Geneva, World Health Organization (WHO/PCS/99.18). 1999 JMPR (2000) Pesticide residues in food – 1999 evaluations. Part II – Toxicological and Environmental. Geneva, World Health Organization (WHO/PCS/00.4). 2000 JMPR (2001) Pesticide residues in food – 2000. Report of the Joint Meeting of the FAO Panel of Experts on Pesticide Residues in Food and the Environment and the WHO Core Assessment Group. FAO Plant Production and Protection Paper 167. 2001 JMPR (2002) Pesticide residues in food – 2001. Joint FAO/WHO Meeting on Pesticide Residues.Evaluations 2001. Part II Toxicological. IPCS International Programme on Chemical Safety & World Health Organization, Geneva 2002 JMPR (2003) Pesticide residues in food – 2002. Joint FAO/WHO Meeting on Pesticide Residues.Evaluations 2002. Part II Toxicological. IPCS International Programme on Chemical Safety & World Health Organization, Geneva 2003 JMPR (2004) Pesticide residues in food – 2003. Joint Meeting of the FAO Panel of Experts on Pesticide Residues in Food and the Environment and the WHO Core Assessment Group. Evaluations 2003. Part II Toxicological. IPCS, World Health Organization, Geneva (WHO/PCS/04.1). 2004 JMPR (2006) Pesticide residues in food – 2004. Joint Meeting of the FAO Panel of Experts on Pesticide Residues in Food and the Environment and the WHO Core Assessment Group. Evaluations 2004. Part II Toxicological. IPCS, World Health Organization, Geneva (WHO/PCS/06.1). 2005 JMPR (2006) Pesticide residues in food – 2005. Joint Meeting of the FAO Panel of Experts on Pesticide Residues in Food and the Environment and the WHO Core Assessment Group. Evaluations 2005. Part II Toxicological. IPCS, World Health Organization, Geneva. 2006 JMPR (2008) Pesticide residues in food – 2006. Joint Meeting of the FAO Panel of Experts on Pesticide Residues in Food and the Environment and the WHO Core Assessment Group. Evaluations 2006. Part II Toxicological. IPCS, World Health Organization, Geneva. 2007 JMPR (2009) Pesticide residues in food – 2007. Joint Meeting of the FAO Panel of Experts on Pesticide Residues in Food and the Environment and the WHO Core Assessment Group. Evaluations 2007. Part II Toxicological. IPCS, World Health Organization, Geneva. 2008 JMPR (2010) Pesticide residues in food – 2008. Joint Meeting of the FAO Panel of Experts on Pesticide Residues in Food and the Environment and the WHO Core Assessment Group. Evaluations 2008. Part II Toxicological. IPCS, World Health Organization, Geneva. 2009 JMPR (2011) Pesticide residues in food – 2009. Joint Meeting of the FAO Panel of Experts on Pesticide Residues in Food and the Environment and the WHO Core Assessment Group. Evaluations 2009. Part II Toxicological. World Health Organization, Geneva.

JMPR evaluations by year 19 2010 JMPR (2011) Pesticide residues in food – 2010. Joint Meeting of the FAO Panel of Experts on Pesticide Residues in Food and the Environment and the WHO Core Assessment Group. Evaluations 2010. Part II Toxicological. World Health Organization, Geneva. 2011 JMPR (2012) Pesticide residues in food – 2011. Joint Meeting of the FAO Panel of Experts on Pesticide Residues in Food and the Environment and the WHO Core Assessment Group. Evaluations 2011. Part II Toxicological. World Health Organization, Geneva. 2012 JMPR (2013) Pesticide residues in food – 2012. Joint Meeting of the FAO Panel of Experts on Pesticide Residues in Food and the Environment and the WHO Core Assessment Group. Evaluations 2012. Part II Toxicological. World Health Organization, Geneva. 2013 JMPR (2014) Pesticide residues in food – 2013. Joint Meeting of the FAO Panel of Experts on Pesticide Residues in Food and the Environment and the WHO Core Assessment Group. Evaluations 2013. Part II Toxicological. World Health Organization, Geneva. 2014 JMPR (2015) Pesticide residues in food – 2014. Joint Meeting of the FAO Panel of Experts on Pesticide Residues in Food and the Environment and the WHO Core Assessment Group. Evaluations 2014. Part II Toxicological. World Health Organization, Geneva. 2015 JMPR (2016) Pesticide residues in food – 2015. Joint Meeting of the FAO Panel of Experts on Pesticide Residues in Food and the Environment and the WHO Core Assessment Group. Evaluations 2015. Part II Toxicological. World Health Organization, Geneva. 2016 JMPR (2017) Pesticide residues in food – 2016. Joint Meeting of the FAO Panel of Experts on Pesticide Residues in Food and the Environment and the WHO Core Assessment Group. Evaluations 2016. Part II Toxicological. World Health Organization, Geneva. 2017 JMPR (2017) Pesticide residues in food 2017. Report of the Joint Meeting of the FAO Panel of Experts on Pesticide Residues in Food and the Environment and the WHO Core Assessment Group on Pesticide Residues. Food and Agriculture Organization of the United Nations and World Health Organization, Rome. 2018 JMPR (2019) Pesticide residues in food – 2018. Joint Meeting of the FAO Panel of Experts on Pesticide Residues in Food and the Environment and the WHO Core Assessment Group. Evaluations 2018. Part II Toxicological. World Health Organization, Geneva.

20 The WHO Recommended Classification of Pesticides by Hazard 1995 , ; 1985 , EHC 195 JMPR 1992 ; ICSC 407 = 33 mg/kg] = 3.7 mg/kg] 50 50 JMPR 1977 ; ICSC 94 1996 , LD ; [Oral ; [Oral LD ; [Oral ICSC 1681 ICSC 119 ICSC 895 ; HSG 64; ; ; ICSC 753 ICSC 979 JMPR 1992 JMPR 1999 EHC 121

; ; JMPR 1996 ICSC 1756 ICSC 1757 ICSC ICSC 1267 ; ; HSG 93 ; HSG 94 ; ; HSG 95 ; ; (Group 2A) (Group (Group 2B)

= 12.5 mg/kg); 50 Remarks See 3; note EHC 175 EHC 175 1; see note classification; Adjusted 2 and 3; HSG 49; see notes classification; Adjusted IARC 53 skin by Extremely hazardous contact (LD ICSC 1682 EHC 175 EHC 175 EHC 175 EHC 175 ICSC 1408 See 4; note ICSC 1660 EHC 175 3 and 5); (notes classification Adjusted IARC 79 See 3; note ICSC 924 JMPR 2017

50 LD mg/kg 0.93 0.3 1.12 2 39 5000 1.8 D27 3.1 1.8 0.56 2.3 2.6 14 D26 0.25 D10000 1 D4 2.5 1 1 1 1 1 2 5 1 2 1 1 1 2 2 1 5 1 1 1 1 GHS I I I I I I F R R R R R R R R I-S I-S FM F-S FST use Main S L L L L L S S S S S S S S S S S S S S Phys Phys state C C OP OP OP OP OP OP CO CO CO OC HG type Chem Chem no UN 2757 2757 3027 3027 2588 1575 3018 3018 2588 3027 2588 2588 3018 2783 3018 3027 2729 1624 3018 CAS no  116-06-3  56073-10-0  28772-56-7  63333-35-7  592-01-8  2425-06-1  54593-83-8  24934-91-6  3691-35-8  56073-07-5  104653-34-1  82-66-6  298-04-4  2104-64-5  13194-48-4  90035-08-8  118-74-1  7487-94-7  7786-34-7  23135-22-0  Common name Common Aldicarb [ISO] [ISO] Brodifacoum [ISO] Bromadiolone [ISO] Bromethalin cyanideCalcium [C] [ISO] Captafol [ISO] Chlorethoxyfos Chlormephos [ISO] [ISO] Chlorophacinone [ISO] Difenacoum [ISO] Difethialone Diphacinone [ISO] [ISO] Disulfoton EPN [ISO] Ethoprophos Flocoumafen [ISO] Hexachlorobenzene Mercuric chloride [ISO] Mevinphos [ISO] [ISO] Oxamyl Table 1. Extremely technical active grade ingredients in 1. pesticides Ia) hazardous (Class Table

Table 1. Extremely hazardous (Class Ia) technical grade active ingredients in pesticides 21 , ; 9.4 mg/kg ). ICSC 540 50 ICSC 6 ; JMPR 1984 ; ICSC 492 ICSC ICSC 626 ICSC 1060 (Group 2B) (Group ; See table 7, p. 65 See table 7, p. 2004 2003 , , JMPR 1986 ; ; HSG 75; IARC 112 High case fatality reportedHigh case 6 – see note EHC 145 ICSC 189 ; JMPR 1996 JMPR 1990

; and phosphamidon is regulated by the Rotterdam the Rotterdam by and phosphamidon is regulated ICSC 1767 phorate Remarks See 3; HSG 74; note JMPR 1995 See 3; note 1995 3 and 7; see notes classification; Adjusted See 3; note See 3; note ICSC 484 ICSC 985 skin by Extremely hazardous contact (LD in rats); 1768 ICSC

50 LD mg/kg 13 14 24 2 7 0.2 5 1.3 c2 2 1 2 1 1 1 2 2 1 GHS Hydrogen cyanide is fatal if swallowed, in contact with skin in contact or if inhaled ( if swallowed, is fatal cyanide Hydrogen , and the Annex I I I I I I R I-S FST use Main L L L L L L L S S Phys Phys Pages 8 & 9 Pages state See DEPENDS ON ITS FORMULATION DEPENDS ON ITS OP OP OP OP OP OP OP HG type Chem Chem ), which entered into force on 24 February 2004 and has subsequently been amended. been amended. 2004 and has subsequently on 24 February force into ), which entered THE FINAL CLASSIFICATION OF ANY PRODUCT OF ANY THE FINAL CLASSIFICATION no UN 3018 3018 1674 3018 3018 2629 1704 3018 3018 ), which entered into force on 17 May, 2004 and has subsequently been amended. 2004 and has subsequently on 17 May, force into ), which entered http://www.pic.int/ CAS no  56-38-2  298-00-0  62-38-4  298-02-2  13171-21-6  62-74-8  3689-24-5  96182-53-5  13071-79-9  captafol, hexachlorobenzene, mercury compounds, parathion, parathion-methyl, parathion-methyl, parathion, mercury compounds, hexachlorobenzene, captafol, http://www.pops.int/ aldicarb, Convention on Prior Informed Consent (see Informed Consent on Prior Convention (see pollutants organic persistent fatality 2010). has been (Dawson reported with this substance A high case et al, in poisoning cases Calcium cyanide is in Class Ia as it reacts with moisture to produce hydrogen cyanide gas. hydrogen cyanide produce to Calcium is in Class Ia as it reacts with moisture and mice. in both rats is carcinogenic Captafol of trade international The in hens. neurotoxicity EPN has been reported as causing delayed on the Stockholm restricted by Convention is severely use and production of hexachlorobenzene The in humans. of porphyria has caused a serious outbreak Hexachlorobenzene in the rat. lesions: teratogenic renal produced mammals and very to small doses have is highly toxic acetate Phenylmercury Common name Common [ISO] Parathion [ISO] Parathion-methyl [ISO] acetate Phenylmercury [ISO] Phorate Phosphamidon [C] Sodium fluoroacetate [ISO] Sulfotep [ISO] Tebupirimfos [ISO] Terbufos Table 1. Extremely hazardous (Class Ia) technical grade active ingredients in pesticides (cont.) active ingredients grade Ia) technical (Class 1. Extremely hazardous Table Risks Humans; ICSC = International to of Carcinogenic Guide; IARC on the Evaluation HSG = Health and Safety = IARC Monograph; Monographs Health Criteria EHC = Environmental Residues. Meeting on Pesticide FAO/WHO the Joint by JMPR = Evaluation Card; Chemical Safety Ia Class to Notes 1. 2. 3. 4. 5. 6. 7.

22 The WHO Recommended Classification of Pesticides by Hazard , ; JMPR 1969 9.4 mg/kg ; ). ICSC 540 50 ICSC 6 2008 ; JMPR 1984 ; Adjusted ; Adjusted , ; ICSC 492 ICSC 2002 ICSC 765 2007 , ; , ICSC 95 Adjusted classification classification Adjusted ; ICSC 626 ICSC 1060 (Group 2B) (Group ; See table 7, p. 65 See table 7, p. 2004 2003 , , ; See4 note JMPR 1986 JMPR 1996 (see note 5) (see note

JMPR 1992 ; ; ICSC 1664 ICSC ; HSG 75; IARC 112 ; ICSC 90 IARC 84 High case fatality reportedHigh case 6 – see note ; EHC 145 ICSC 189 ICSC 122 JMPR 1994 ; ; Adjusted classification (see note 3) (see note classification ; Adjusted ; See4 note JMPR 1996 ICSC 826 JMPR 1990 JMPR 2006

; JMPR 1990 ; ; ; (Group 2B); (Group ; HSG 67; and phosphamidon is regulated by the Rotterdam the Rotterdam by and phosphamidon is regulated 224 ICSC 1767 , 2009 phorate Remarks See 3; HSG 74; note JMPR 1995 See 3; note 1995 3 and 7; see notes classification; Adjusted See 3; note See 3; note ICSC 484 ICSC 985 skin by Extremely hazardous contact (LD in rats); 1768 ICSC Remarks JMPR 2015 EHC 127 Highly skin irritant to and eyes; 3) (see note classification JMPR 1973 See 2; note 1758 ICSC 3) (see note classification Adjusted JMPR 1985 3) (see note classification Adjusted JMPR EHC 18 See 2; note ICSC 1305 IARC 101 1 and 3) (see notes ICSC 422 1764 ICSC JMPR 2006

50 50 LD mg/kg 8.7 29 64 12 16 16 71 158 D288 30 20 8 31 112 7.1 16 c15 c11 LD mg/kg 13 14 24 2 7 0.2 5 1.3 c2 2 1 2 1 1 1 2 2 1 GHS GHS 2 2 3 2 2 2 3 3 3 2 2 2 2 3 2 2 2 2 Hydrogen cyanide is fatal if swallowed, in contact with skin in contact or if inhaled ( if swallowed, is fatal cyanide Hydrogen , and the Annex I I I I I I R I-S FST use Main use AC,I,N H H I I F I I I N,I I I I R AC,MT R I I Main L L L L L L L S S Phys Phys Pages 8 & 9 Pages state Phys Phys state S L L S S S L L L L S S L L S S S S See DEPENDS ON ITS FORMULATION DEPENDS ON ITS OP OP OP OP OP OP OP HG type Chem Chem Chem Chem type OP OP OP C C OP AS C OP OP CO PY PY ), which entered into force on 24 February 2004 and has subsequently been amended. been amended. 2004 and has subsequently on 24 February force into ), which entered THE FINAL CLASSIFICATION OF ANY PRODUCT OF ANY THE FINAL CLASSIFICATION no UN UN no 2588 1092 1098 2783 2783 2588 2992 2992 3018 1573 2757 3018 2689 2783 3027 3018 3018 1674 3018 3018 2629 1704 3018 3018 ), which entered into force on 17 May, 2004 and has subsequently been amended. 2004 and has subsequently on 17 May, force into ), which entered http://www.pic.int/ CAS no  71751-41-2  107-02-8  107-18-6  2642-71-9  86-50-0  2079-00-7  4824-78-6  34681-10-2  34681-23-7  95465-99-9  7778-44-1  1563-66-2  470-90-6  96-24-2  56-72-4  5836-29-3  68359-37-5  1820573-27-0  CAS no  56-38-2  298-00-0  62-38-4  298-02-2  13171-21-6  62-74-8  3689-24-5  96182-53-5  13071-79-9  captafol, hexachlorobenzene, mercury compounds, parathion, parathion-methyl, parathion-methyl, parathion, mercury compounds, hexachlorobenzene, captafol, http://www.pops.int/ aldicarb, Convention on Prior Informed Consent (see Informed Consent on Prior Convention (see pollutants organic persistent fatality 2010). has been (Dawson reported with this substance A high case et al, in poisoning cases Calcium cyanide is in Class Ia as it reacts with moisture to produce hydrogen cyanide gas. hydrogen cyanide produce to Calcium is in Class Ia as it reacts with moisture and mice. in both rats is carcinogenic Captafol of trade international The in hens. neurotoxicity EPN has been reported as causing delayed on the Stockholm restricted by Convention is severely use and production of hexachlorobenzene The in humans. of porphyria has caused a serious outbreak Hexachlorobenzene in the rat. lesions: teratogenic renal produced mammals and very to small doses have is highly toxic acetate Phenylmercury Common name Common [ISO] Parathion [ISO] Parathion-methyl [ISO] acetate Phenylmercury [ISO] Phorate Phosphamidon [C] Sodium fluoroacetate [ISO] Sulfotep [ISO] Tebupirimfos [ISO] Terbufos name Common Abamectin [ISO] [C] Acrolein [C] alcohol Allyl Azinphos-ethyl [ISO] Azinphos-methyl [ISO] Blasticidin-S Bromophos-ethyl [ISO] [ISO] Butocarboxim [ISO] Butoxycarboxim [ISO] Cadusafos [C] arsenate Calcium Carbofuran [ISO] Carbofuran Chlorfenvinphos [ISO] 3-Chloro-1,2-propanediol [C] [ISO] Coumaphos [ISO] Coumatetralyl [ISO] Cyfluthrin Beta-cyfluthrin [ISO] EHC = Environmental Health Criteria Monograph; HSG = Health and Safety Guide; IARC = IARC Monographs on the Evaluation of Carcinogenic Risks Humans; ICSC = International to of Carcinogenic Guide; IARC on the Evaluation HSG = Health and Safety = IARC Monograph; Monographs Health Criteria EHC = Environmental Residues. Meeting on Pesticide FAO/WHO the Joint by JMPR = Evaluation Card; Chemical Safety Ia Class to Notes 1. 2. 3. 4. 5. 6. 7. technical active grade ingredients in 2. pesticides Ib) Highly hazardous (Class Table

Table 2. Highly hazardous (Class Ib) technical grade active ingredients in pesticides 23 ; ICSC 690 ; ; See2 note (Group 2B) (Group

. See2. note 2002 , IARC 53 JMPR 1969 ICSC 462 2002 ; ; . Adjusted classification (see classification . Adjusted , . See2 note JMPR 1989 ; JMPR 1990 ; ; Adjusted classification (see note 3) (see note classification ; Adjusted ; HSG 18; EHC 220 ICSC 911 ; ; 2011 JMPR 1997 , a . Adjusted classification (see note 3) (see note classification . Adjusted (see classification 4; Adjusted ; see note JMPR 1982 JMPR 1986 . See2 note ; JMPR 1997 CICAD 50 ; ; ICSC 705 ; ; EHC 79 ; ICSC 176 224 , Remarks EHC 197 Volatile; JMPR 1993 ICSC 872 JMPR 1965 JMPR 1981 1754 ICSC 3) note ICSC 483 JMPR 1985 3) note ICSC 1434 3) (see note classification Adjusted 3) (see note classification Adjusted EHC 18 1755 ICSC ICSC 981 HSG 79; ICSC 1659

50 LD mg/kg 40 57-108 22 25 25 150 200 48 15 c67 13 21 42 96 112 c10 36 18 30 25 GHS 2 3 2 2 2 3 3 2 2 3 2 2 2 3 3 2 2 2 2 2 Main use I I I H I-S,H F I I N I R AC I-S I I L I O I I Phys Phys state L L L S S L L S S L S S L L L S Oil S S L Chem Chem type OP OP OP NP NP OP C OP OP PY C C OP OP AS OP HG OP OP UN no 3018 3018 3018 2779 1598 3018 2992 2783 2783 3352 2588 2757 2992 3018 3018 1617 3018 1641 2783 3018 CAS no  919-86-8  62-73-7  141-66-2  1420-07-1  534-52-1  17109-49-8  29973-13-5  52-85-7  22224-92-6  70124-77-5  640-19-7  22259-30-9  65907-30-4  23560-59-0  18854-01-8  7784-40-9  2595-54-2  21908-53-2  10265-92-6  950-37-8  Common name Common [ISO] Demeton-S-methyl Dichlorvos [ISO] [ISO] Dicrotophos [ISO] Dinoterb DNOC [ISO] Edifenphos [ISO] Edifenphos [ISO] Ethiofencarb Famphur [ISO] Fenamiphos [ISO] Flucythrinate [C] Fluoroacetamide [ISO] Formetanate Furathiocarb [ISO] Heptenophos [ISO] Isoxathion [C] arsenate Lead Mecarbam [ISO] [ISO] Mercuric oxide Methamidophos [ISO] Methidathion [ISO] Table 2. Highly hazardous (Class Ib) technical grade active ingredients in pesticides (cont.) active ingredients grade technical Ib) (Class 2. Highly hazardous Table

24 The WHO Recommended Classification of Pesticides by Hazard IARC 117 High case High case ; 2001 , ; HSG 19; JMPR 1995 ICSC 1603 ; ; JMPR 1989 EHC 71 , ; Adjusted classification classification ; Adjusted classification ; Adjusted ICSC 181 ICSC 177 ICSC 821 (see note 5) (see note

; Adjusted classification (see note 3) (see note classification ; Adjusted 3) (see note classification ; Adjusted 1996 2002 2002 ICSC 758 CICAD 61 ; , , ; JMPR 1998 ICSC69 ; JMPR 1979 ; IARC 84 ICSC 336 ; ; ; HSG 97; ; ; ; HSG 96; ICSC 602 ; Remarks 1766 ICSC EHC 178 See 2; HSG 80; note fatality reported 6. – see note ICSC 519 JMPR 1985 JMPR 1989 complex Copper-arsenic See 2; Irritant note skin; to 1) (Group 3) (see note classification Adjusted EHC 224 ICSC 1118 ICSC 197 See 4 note EHC 182 ICSC 580 3) (see note JMPR 1993 JMPR 1988 3) (see note EHC 175 EHC 73

50 LD mg/kg 20 17 14 D50 50 65 22 D80 106 10 6 16 c22 11 8 120 82 103 10 40.5 GHS 2 2 2 1 2 3 2 2 3 2 2 2 2 2 2 3 3 3 2 2 Main use I I I I I L I,F,H I R R R I-S R I-S I I I R R Phys Phys state S S S L L L S S L S S S S S S Oil L L S S Chem Chem type C C OP OP OP AS OP AS PY C OP OP OP CO UN no 2757 2757 2783 1654 3018 3018 1585 3155 3018 2027 1689 1692 3349 1707 2757 3018 3018 3018 3027 1714 CAS no  2032-65-7  16752-77-5  6923-22-4  54-11-5  1113-02-6  301-12-2  12002-03-8  87-86-5  31218-83-4  7784-46-5  143-33-9  57-24-9  79538-32-2  7446-18-6  39196-18-4  640-15-3  24017-47-8  2275-23-2  81-81-2  1314-84-7  Common name Common Methiocarb [ISO] Methomyl [ISO] Methomyl [ISO] Monocrotophos Nicotine [ISO] [ISO] Omethoate [ISO] Oxydemeton-methyl [C] green Paris [ISO] Pentachlorophenol [ISO] Propetamphos Sodium [C] arsenite Sodium cyanide [C] Strychnine [C] Tefluthrin [C] sulfate Thallium [ISO] Thiofanox [ISO] Thiometon [ISO] Triazophos [ISO] Vamidothion Warfarin [ISO] Zinc phosphide [C] Table 2. Highly hazardous (Class Ib) technical grade active ingredients in pesticides (cont.) active ingredients grade technical Ib) (Class 2. Highly hazardous Table

Table 2. Highly hazardous (Class Ib) technical grade active ingredients in pesticides 25 ), In . table 7, p. 65 table 7, p. http://www.pops.int/ , and the Annex Pages 8 & 9 Pages ), which entered into force on 24 February 2004 and has subsequently been amended. See been amended. 2004 and has subsequently on 24 February force into ), which entered See DEPENDS ON ITS FORMULATION DEPENDS ON ITS value chosen for classification purposes is generally based on administration in corn oil and can be much lower than that much lower can be corn oil and in based on administration purposes is generally chosen for classification value 50 in experimental animals for the carcinogenicity of calcium arsenate and sodium arsenite (IARC and sodium arsenite 84). arsenate of calcium in experimental animals for the carcinogenicity THE FINAL CLASSIFICATION OF ANY PRODUCT OF ANY THE FINAL CLASSIFICATION http://www.pic.int/ values. The single LD The values. limited evidence limited 50 carbofuran, DNOC, fluoroacetamide, mercury compounds, methamidophos, monocrotophos and pentachlorophenol is regulated by the regulated is and pentachlorophenol monocrotophos methamidophos, mercurycompounds, DNOC, fluoroacetamide, carbofuran, azinphos-methyl, Rotterdam Convention on Prior Informed Consent (see Informed Consent on Prior Convention Rotterdam pollutants (see organic on persistent the Stockholm strictly Convention by are limited and its salts esters addition, the production and use of pentachlorophenol 2004 and has subsequently been amended. on 17 May, force into which entered are describedintroductory for in the Categories notes Toxicity Hazard Acute with the GHS has been aligned WHO Classification the with the GHS. WHO Classification Details of how the II. Part LD ‘c’ before in the prefix is reflected variability in aqueous solutions. This underlines the need for classification by formulation if the classification is to reflect to true hazard. is if the classification by formulation underlines the need for classification This in aqueous solutions. 3-Chloro-1,2-propanediol in nonlethal dosage is a sterilant for male rats. This compound is also known compound as alpha-chlorohydrin. This male rats. 3-Chloro-1,2-propanediol for in nonlethal dosage is a sterilant of trade international The of aligning process Class in the hazardous to a less those pesticides being assigned certainavoid of the classification to a precautionary been adjusted As pesticides has liquid measure, The toxicity data for pyrethroids is highly variable according to isomer ratios, the vehicle used for oral administration, and the husbandry of the test animals e.g. fasting prior to dosing. The The dosing. prior to fasting and the husbandry animals e.g. administration, of the test used for oral the vehicle isomer ratios, to according is highly variable data for pyrethroids toxicity The was that there 84 concluded IARC Monograph fatality 2010). has been (Dawson reported with this substance A high case et al, in poisoning cases

Table 2. Highly hazardous (Class Ib) technical grade active ingredients in pesticides (cont.) active ingredients grade technical Ib) (Class 2. Highly hazardous Table Risks Humans; ICSC = International to of Carcinogenic Guide; IARC on the Evaluation HSG = Health and Safety = IARC Monograph; Monographs Health Criteria EHC = Environmental Residues. Meeting on Pesticide FAO/WHO the Joint by JMPR = Evaluation Card; Chemical Safety Ib Class to Notes 1. 2. 3. 4. 5. 6.

26 The WHO Recommended Classification of Pesticides by Hazard 2016 , JMPR 1965a ; 2012 , 2004 ICSC 212 , ICSC 748 ; ; HSG 24; ICSC 371 JMPR 1998 2005 2005 ; ; , , EHC 87 and 3 2002 1994 2009 , , , JMPR 1998 ICSC 828 ; Remarks JMPR 1990 JMPR 2011 eyes irritant to Strong See 1 notes See 10; note JMPR 1989 ICSC 383 HSG 48; JMPR 2013 JMPR 1992 Irritant to skinIrritant to and eyes ICSC 98

50 LD mg/kg 945 c140 1370 930 330 c685 700 110 800 472 308 1010 80 1300 55 205 270 1100 1100 55 c55 268 3 4 3 3 4 4 4 4 4 4 3 3 3 3 4 4 3 3 4 4 4 4 GHS I I I I I I I I I F F H H H H H H H H H AC AC use Main L S S S L L S S S S S S S S S S S S S S S Oil Phys Phys state T C C C PZ PY PY OT OP OP OP type Chem Chem no UN 2588 2588 2786 2757 2992 2902 3349 2588 30560-19-1  135410-20-7  50594-66-6  15972-60-8  83130-01-2  35575-96-3  41083-11-8  22781-23-3  82560-54-1  25057-89-0  1072957-71-1  71048-99-2  CAS no  584-79-2  93-71-0  834-12-8  33089-61-1  64249-01-0  60207-31-0  101-27-9  741-58-2  17606-31-4  82657-04-3  Common name Common [ISO] Acephate [ISO] Acetamiprid Acifluorfen [ISO] [ISO] Alachlor [ISO] Alanycarb Allethrin [ISO] Allidochlor [ISO] Azamethiphos [ISO] Azocyclotin [ISO] Barban [ISO] Bendiocarb [ISO] Benfuracarb [ISO] Bensulide [ISO] Bensultap [ISO] [ISO] Bentazone [ISO*] Benzovindiflupyr Bifenthrin [ISO] Bilanafos Ametryn [ISO] [ISO] Amitraz [ISO] Anilofos Azaconazole Table 3. Moderately hazardous (Class II) technical active grade ingredients II) Moderately in pesticides 3. hazardous (Class Table

Table 3. Moderately hazardous (Class II) technical grade active ingredients in pesticides 27 2001 ,

2000 , 1984 , IARC 79 2017 JMPR 1996 , ; ; HSG 13; JMPR 1981 ; 1999 JMPR 1994 , ; Usually used in the form of cartapUsually ICSC 227 ; EHC 34 High case fatality reportedHigh case – ICSC 121 ; Irritant to skin; Irritant to ; ICSC 401 2003 ICSC 740 , EHC 15 ; JMPR 1997 skin; ; ; HSG 78; JMPR 1995 ; ant to ant See 3 and 4; notes 2B) (Group Irrit EHC 153 JMPR 1986 15 see note EHC 76 15263-52-2) (CAS hydrochloride ICSC 781 sodium salt; to Irritant skin refer to data and eyes; ICSC 235 Remarks See 2 and 10; notes See 3; note ICSC 1264 ICSC 415

50 c300 250 325 400 460 575 441 433 650 1635 380 LD mg/kg c700 194 1217 c1600 190 365 254 630 1049 4 3 4 4 3 3 4 4 4 4 4 4 4 3 4 3 4 4 4 4 GHS I I I I I I F F R B H H H H H H H F,M use PGR I,MT Main L S S S L L L L L S S S S S S S S S S S Phys Phys state C C TC PY OP OP OC OC type Chem Chem no UN 2992 2996 1992 2757 1751 2588 3241 85-34-7  63-25-2  55285-14-8  15263-53-3  15879-93-3  57-74-9  122453-73-0  999-81-5  79-11-8  56-35-9  13181-17-4  36335-67-8  138164-12-2  13952-84-6  CAS no  260359-57-7  2104-96-3  1689-84-5  116255-48-2  52-51-7  33629-47-9  Carbosulfan [ISO] Carbosulfan Cartap [ISO] [C] Chloralose [ISO] Chlordane Chlorfenac [ISO] Chlorfenapyr [ISO] chlorideChlormequat [ISO] acid [C] Chloroacetic Carbaryl [ISO] Common name Common Bioallethrin [C] Bis(tributyltin) [C] oxide [ISO] Bromofenoxim [ISO] Bromophos [ISO] Bromoxynil Bromuconazole Bronopol [ISO] Butamifos [ISO] Butralin [ISO] Butroxydim Butylamine [ISO] Table 3. Moderately hazardous (Class II) technical grade active ingredients in pesticides (cont.) active ingredients grade II) technical (Class hazardous 3. Moderately Table

28 The WHO Recommended Classification of Pesticides by Hazard ; ; ; JMPS 2019 ; JMPR 1984 JECFA 1996 JECFA ; JMPR 2007 ; JMPR 2006 ; ICSC 858 JMPR 2006 ICSC 246 ; HSG 38; ; JECFA 1996 JECFA ; 2005 EHC 142 ; HSG 38; ; HSG 22; ICSC 246 ICSC , ; EHC 99 EHC 82 EHC 142 JMPR 1999 EHC 200 ; , JMPR 1994 ; JECFA 2000b JECFA ; Remarks Irritant skin to and eyes ICSC 851 852 ICSC ICSC 751 ICSC 421 ICSC 391 See 10; note 2007 See 10 and 11 notes ICSC 859 EHC 15 See 10; note JMPR 2006 See 10; note See 22; 10; HSG note JMPR 2010

50 LD mg/kg 178 135 757 1369 389 1000 1440 300 850 470 288 610 c144 c56 265 1196 c250 c79 c269 318 4 3 4 3 3 4 4 3 4 4 3 4 3 3 3 4 3 3 4 4 GHS I I I I I I I I F F F F F H H H Ix AC use PGR PGR Main L S S L L L L S S S S S S S S S S S S Oil Phys Phys state T PY PY PY PY PY PY OT OP OP CU CU CU CU PAA type Chem Chem no UN 2588 3352 2588 2783 3352 3352 3349 3352 115-78-6  2921-88-2  1332-40-7  7758-98-7  2636-26-2  68085-85-8  13121-70-5  52315-07-8  67375-30-8  CAS no  1918-13-4  81777-89-1  210880-92-5  20427-59-2  122-88-3  1317-39-1  21725-46-2  91465-08-6  57966-95-7  1315501-18-8 39515-40-7  Common name Common Chlorphonium chloride [ISO] [ISO] Chlorpyrifos Chlorthiamid [ISO] [ISO] Clomazone Clothianidin [ISO] [C] oxychloride Copper [C] sulfate Copper [ISO] 4-CPA [C] oxide Cuprous [ISO] Cyanazine [ISO] Cyanophos [ISO] Cyhalothrin Lambda-cyhalothrin [ISO] Cyhexatin [ISO] Cymoxanil [ISO] Cypermethrin Alpha-cypermethrin [ISO] Zeta-cypermethrin [ISO] [ISO] Cyphenothrin Copper hydroxide [C] hydroxide Copper Table 3. Moderately hazardous (Class II) technical grade active ingredients in pesticides (cont.) active ingredients grade II) technical (Class hazardous 3. Moderately Table

Table 3. Moderately hazardous (Class II) technical grade active ingredients in pesticides 29 , , ; ; ; JMPR 1993 ICSC 33 JMPR 1992 ; ; ; (Group 2A) (Group (Group 3) (Group

ICSC 137 IARC 53 ICSC 37 IARC 113 ICSC 752 ; ; (Group 2B) (Group 2000 83 , , ICSC 786 1994 ; HSG 30; , (Group 3) (Group IARC 113 EHC 9

(Group 2A); (Group EHC 97 2016 2004 , , IARC 30 ; HSG 5; JMPR 2000 IARC 112 ; JMPR 1984 ; 84 ; , 2006 , JMPR 2007 JMPR 1999 ICSC 38 See 4; note 2011 JMPR 1996 Irritant skin to and eyes; See 3 and 4; notes ICSC 34 See 10; note ICSC 247 EHC 198 2001 ICSC 139 Mixture of isomers: ortho (3) 95-50-1, meta (2B) 106-46-7; 541-73-1, para Remarks EHC 29

50 1453 470 946 1600 1180 800 565 c690 113 c135 300 1707 500- 5000 1250 375 640 700 LD mg/kg 1020 4 4 4 4 4 3 3 4 4 4 4 4 4 4 4 4 4 4 GHS I I I F F F H H H H H H H H H AC FM F-S use Main L S S S S S S S S S S S S S S S S S Phys Phys state TC PY OP OC OC OC PAA type Chem Chem no UN 2588 3349 3018 2761 3345 43222-48-6  61432-55-1  50563-36-5  55290-64-7  120-36-5  40843-25-2  115-32-2  119446-68-3  94-82-6  50-29-3  52918-63-5  333-41-5  1918-00-9  106-46-7  97-23-4  94-75-7  533-74-4  CAS no  94361-06-5  Difenzoquat [ISO] Difenzoquat [ISO] Dimepiperate Dimethachlor [ISO] Dimethipin [ISO] Deltamethrin [ISO] Diazinon [ISO] Dicamba [ISO] [C] Dichlorobenzene [ISO] Dichlorophen [ISO] Dichlorprop [ISO] Diclofop [ISO] Dicofol [ISO] Difenoconazole Dazomet [ISO] Dazomet 2,4-DB [ISO] DDT Common name Common Cyproconazole 2,4-D [ISO] Table 3. Moderately hazardous (Class II) technical grade active ingredients in pesticides (cont.) active ingredients grade II) technical (Class hazardous 3. Moderately Table

30 The WHO Recommended Classification of Pesticides by Hazard ; High EHC 39 ; ; 2007 , 2003 , JMPR 2005 ICSC 742 2013 , JMPR 2000 ; JMPR 1996 ; ; HSG 17; JMPR 1993 ; ICSC 622 2013 EHC 40 , ; ICSC 741 2010 High case fatality reportedHigh case 15 – see note ICSC 1516 , ; ; JMPR 2000 JMPR 1990 ; US EPA Pesticide Fact Sheet 2010; Used as a Fact Pesticide EPA ; US ; ; ; HSG 65; ICSC 1363 ; HSG 20; of P isomer is 429 mg/kg bw; 50 ICSC 881 ICSC 763 Irritant skin to and damages nails; and eyes HSG 52; JMPR 1993 JMPR 2000 Remarks LD 1586 ICSC Cat. 3) (GHS if inhaled Toxic fumigant – classified as EHC 90 fatality reportedcase 15 – see note JMPR 2011 See 3 and 4 notes JMPR 1998 ICSC 469 JMPR 2002 ICSC 888 JMPR 2017 EHC 133

50 640 1000 1350 190 c150 639 140 980 970 231 53-237 80 51 1652 87 208 134 503 LD mg/kg 371 3 3 4 3 4 4 3 4 4 4 4 3 3 3 4 3 3 3 4 GHS I I I I I I F F F H H H H H H AC use AC,F AC,F Main FM,H,I,N L S L L L L S S S S S S S S S S S S S Phys Phys state TC PY BP AS NP NP OP OP OP OC type Chem Chem no UN 2381 2588 2779 2781 2761 2588 3349 3018 1572 2783 2588 957-51-7  2764-72-9  3347-22-6  87674-68-8  75-60-5  624-92-0  60-51-5  83657-24-3  973-21-7  39300-45-3  2439-10-3  155569-91-8  115-29-7  129-67-9  759-94-4  66230-04-4  563-12-2  120928-09-8  122-14-5  CAS no  Dinobuton [ISO] Dinobuton Dinocap [ISO] Diphenamid [ISO] [ISO] Diquat Dithianon [ISO] Dodine [ISO] [ISO] Emamectin Benzoate Common name Common Dimethenamid [ISO] acid [C] Dimethylarsinic [C] disulfide Dimethyl [ISO] Dimethoate [ISO] Diniconazole Endosulfan [ISO] Endothal-sodium [(ISO)] [ISO] EPTC [ISO] Esfenvalerate [ISO] Ethion [ISO] Fenazaquin [ISO] Fenitrothion Table 3. Moderately hazardous (Class II) technical grade active ingredients in pesticides (cont.) active ingredients grade II) technical (Class hazardous 3. Moderately Table

Table 3. Moderately hazardous (Class II) technical grade active ingredients in pesticides 31 ; (Group 3) (Group

CICAD 13 = 0.21-0.36 mg/l); ; IARC 53 50 2012 , High case fatality reportedHigh case – 2012 ; , CICAD 13 , HSG 34; JMPR 1991 ; ; ICSC 1503 ; JMPR 1993 EHC 95 2017 2000 2007 2016 , , , , JMPR 1997 JMPR 1986 ; ; JMPR 1991 ICSC 1283 ; ; Remarks See 10; note (LC inhalation by Highly toxic JMPR 2007 ICSC 655 15 see note EHC 15 EHC 15 See 10; note ICSC 273 JMPR 1997 JMPR 2015 cause skinMay sensitization JMPR 2015 JMPR 1995 JMPR 2013

50 LD mg/kg 620 1150 1440 c66 245 D586 125 108 c450 725 92 884 1550 671 600 1550 300- 2000 709 672 4 3 4 4 4 3 3 3 3 3 4 4 3 4 4 4 4 4 4 GHS I I I I I I L F F F F F N H H H I,L AC use PGR Main L S S L L L S S S S S S S S S S S S S Phys Phys state C C PY PY OT OT OP type Chem Chem no UN 3349 3018 2786 2786 3352 2588 3766-81-2  62850-32-2  39515-41-8  55-38-9  900-95-8  51630-58-1  89269-64-7  158062-67-0  77501-60-1  951659-40-8  56425-91-3  CAS no  67306-00-7  134098-61-6  76-87-9  120068-37-3  33245-39-5  318290-98-1  142459-58-3  85509-19-9  Common name Common Fenobucarb [ISO] Fenothiocarb [ISO] Fenpropidin [ISO] Fenpropathrin [ISO] Fenpyroximate [ISO] Fenthion acetate[(ISO)] Fentin hydroxide[(ISO)] Fentin [ISO] Fenvalerate [ISO] Ferimzone Fipronil [ISO] Flonicamid [ISO] Fluchloralin [ISO*] Fluensulfone Fluoroglycofen [ISO*] Flupyradifurone [ISO] Flurprimidol Flusilazole Flufenacet [ISO] Flufenacet Table 3. Moderately hazardous (Class II) technical grade active ingredients in pesticides (cont.) active ingredients grade II) technical (Class hazardous 3. Moderately Table

32 The WHO Recommended Classification of Pesticides by Hazard ; (see lindane); ICSC 53 2018 , IARC 20 JMPR 1997 ; 2005 , (Group 1); (Group 2001 , 2002 EHC 123 , IARC 113 (includes Haloxyfop-R and esters) applies to 3:1 mixture of isomers in applies to 50 2008 JMPR 2001 JMPR 2000 ; LD , ; ; JMPR 1997 ; value refers to triacetate; triacetate; to refers value 50 Eye irritant Eye Sheet Fact Pesticide EPA See 12; ECHA 2018; US note 1998 JMPR 2005 use commercial LD JMPR 1995 See 3, 4 and 5; notes ICSC 487 ICSC 1303 ICSC 1501 Remarks JMPR 1998 See 3 and 4; notes JMPR 2003 JMPR 2012

50 550 268 227 450 300 88 >1500 230 300 100 1690 1200 LD mg/kg 1140 282 670 1250 365 336 940 4 3 4 4 3 3 3 4 3 4 4 3 4 4 4 4 4 3 4 GHS I I I I I I I I F F F F H H H H H FST use F,FST Main L L S S S S S S S S S S S S S S S oil oil Phys Phys state PY OP OC OC OC type Chem Chem no UN 3018 2761 2588 2761 72963-72-5  173584-44-6  69806-34-4  67485-29-4  138261-41-3  13516-27-3  88485-37-4  2540-82-1  3878-19-1  57646-30-7  58-89-9  77182-82-2  108173-90-6  608-73-1  51235-04-2  35554-44-0  CAS no  76674-21-0  69409-94-5  72178-02-0  Iminoctadine [ISO] [ISO] Imiprothrin Indoxacarb [ISO] Haloxyfop HCH [ISO] [ISO] Hexazinone Hydramethylnon Imazalil [ISO] Imidacloprid [ISO] Common name Common [ISO] Flutriafol [ISO] Fluvalinate [ISO] Fluxofenim [ISO] Fomesafen [ISO] Formothion [ISO] Fuberidazole [ISO] Furalaxyl Gamma-HCH Lindane [ISO], Glufosinate-ammonium [ISO] Guazatine Table 3. Moderately hazardous (Class II) technical grade active ingredients in pesticides (cont.) active ingredients grade II) technical (Class hazardous 3. Moderately Table

Table 3. Moderately hazardous (Class II) technical grade active ingredients in pesticides 33 ICSC 54 ; CICAD 50 ; 2002 (Group 2B) (Group ICSC 984

, 41 , ICSC 55 See 3; note JMPR 1982 ICSC 1361 Remarks ICSC 900 JMPR 2017 JMPR 2011 IARC 30

50 210 670 700 790 680 930 1050 1920 1490 227 1183 LD mg/kg 110 390 600 403 ≥300 1800 C310 630 4 4 4 4 4 4 3 4 3 4 3 4 4 4 4 4 4 4 4 GHS I F F F F F H H H H H H H H H H H M use PGR Main S S S S S S S S S S S S S S S S S S S Phys Phys state C PZ HG PAA PAA type Chem Chem no UN 2025 1332 2588 2757 15302-91-7  10112-91-1  57837-19-1  26087-47-8  50512-35-1  881685-58-1  55861-78-4  94-74-6  25319-90-8  94-81-5  7085-19-0  16484-77-8  53780-34-0  108-62-3  41394-05-2  CAS no  1689-83-4  3861-47-0  2631-40-5  34123-59-6  Mecoprop [ISO] Mecoprop Mecoprop-P [ISO] Mefluidide [ISO] Mepiquat [ISO] chloride [C] Mercurous Metalaxyl [ISO] [ISO] Metaldehyde [ISO] Metamitron Common name Common Ioxynil [ISO] Ioxynil octanoate [(ISO)] Iprobenfos [ISO] Isoprocarb [ISO] Isoprothiolane [ISO] Isoproturon [ISO*] Isopyrazam [ISO] Isouron Lambda-cyhalothrin – see above Lindane – see Gamma-HCH [ISO] MCPA [ISO] MCPA-thioethyl MCPB [ISO] Table 3. Moderately hazardous (Class II) technical grade active ingredients in pesticides (cont.) active ingredients grade II) technical (Class hazardous 3. Moderately Table

34 The WHO Recommended Classification of Pesticides by Hazard ; Used as a fumigant – ICSC 667 ICSC ICSC 509 ICSC JMPR 2018 2014 , EHC 224 ; (Group 3); (Group 2B); (Group Remarks JMPR 1990 ICSC 755 IARC 71 Cat. 3) (GHS if inhaled Toxic classified as See 6; Skin note irritant and eye See 12; ECHA 2016a note ICSC 516 JMPR 1992 in rats Goitrogenic ICSC 925 IARC 82 See 13. note ICSC 1658 See 14; note

50 LD mg/kg 285 660 678 112 1800 76 72 C50-300 268 322 720 1600 395 430 490 600 867 1072 1080 1250 3 3 4 4 4 3 4 4 3 4 3 3 4 4 4 4 4 4 4 4 GHS I I I I I F F F F F H H H H FM FM F-S F-S B-S use PGR Main L L S S S L L L S S S S S S S S S S S S Phys Phys state C PY TC AS OP OP type Chem Chem no UN 2644 1334 2771 2757 2477 2771 3018 137-42-8  62610-77-9  74-88-4  556-61-6  240494-71-7  21087-64-9  88671-89-0  91-20-3  120-23-0  CAS no  125116-23-6  66952-49-6  124-58-3  1129-41-5  2212-67-1  142-59-6  300-76-5  150824-47-8  1929-82-4  27314-13-2  63284-71-9  Common name Common Metam-sodium [(ISO)] [ISO] Metconazole [ISO] Methacrifos [ISO] Methasulfocarb acid [ISO] Methylarsonic iodide [C]Methyl isothiocyanate [ISO] Methyl [ISO*] Epsilon-metofluthrin Metolcarb [ISO] Metribuzin [ISO] [ISO] Molinate Myclobutanil Nabam [ISO] Naled [ISO] Naphthalene [C] acid [ISO] 2-Napthyloxyacetic [ISO] Nitenpyram Nitrapyrin [ISO] Norflurazon [ISO] Nuarimol [ISO] Table 3. Moderately hazardous (Class II) technical grade active ingredients in pesticides (cont.) active ingredients grade II) technical (Class hazardous 3. Moderately Table

Table 3. Moderately hazardous (Class II) technical grade active ingredients in pesticides 35 , ; 1985 , (Group 3) (Group

JMPR 1982 ; IARC 53 ICSC 5 2001 2003 , , ; HSG 33; ; HSG 51; EHC 94 High case fatality reportedHigh case 15 – see note 2004 2006 2001 2007 2004 ; , , , , , EHC 39 JMPR 2002 JMPR 1997 JMPR 1998 fatality reportedHigh case 15 – see note ; ; ; ; ; HSG 77 2003 , Remarks JMPR 1988 See 7; note 1986 See 10; note ICSC 312 JMPR 1984 ICSC 797 ICSC 543 2000a JECFA JMPR 1982 JMPR 1992 JMPR 1983 JMPR 1990 EHC 147 ICSC 552 JMPR 1987

50 LD mg/kg 1470 1860 1300 150 1120 1050 c220 c400 120 113 D1975 324 147 1667 460 1600 358 1500 c1400 1520 3 4 4 4 3 4 4 4 3 3 4 4 3 4 4 4 4 4 4 4 GHS I I I I I I I F F F F H H H H H H AP use I,AC PGR Main L L L L L L L S S S S S S S S S S S oil oil Phys Phys state C TC PY PY BP OP OP OP OP OP OP OP type Chem Chem no UN 2781 3352 3018 2783 2783 3018 2757 3352 3018 77732-09-3  1114-71-2  52645-53-1  2597-03-7  2310-17-0  732-11-6  14816-18-3  29232-93-7  1918-16-7  60207-90-1  CAS no  26530-20-1  76738-62-0  4685-14-7  40487-42-1  24151-93-7  23103-98-2  23031-36-9  67747-09-5  41198-08-7  709-98-8  Common name Common Octhilinone [ISO] Oxadixyl [ISO] Paclobutrazol [ISO] Paraquat [ISO] Pebulate [ISO] Pendimethalin [ISO] Permethrin [ISO] Phenthoate [ISO] Phosalone [ISO] Phosmet [ISO] Phoxim [ISO] Piperophos [ISO] Pirimicarb [ISO] Pirimiphos-methyl [ISO] Prallethrin [ISO] Prochloraz [ISO] Profenofos [ISO] Propachlor [ISO] Propanil [ISO] Propiconazole Table 3. Moderately hazardous (Class II) technical grade active ingredients in pesticides (cont.) active ingredients grade II) technical (Class hazardous 3. Moderately Table

36 The WHO Recommended Classification of Pesticides by Hazard ; Used as 2017 , ICSC 1475 ; JMPR 2011 ; 2003 , ICSC 944 ICSC 192 ICSC 1068 mg/kg; may cause skin 1068 mg/kg; may sensitisation JMPR 1999 50 JMPR 1989 ; (Group 2B); (Group Dermal LD Remarks ICSC 191 JMPR 1992 See 8; note See 9; HSG 73; note ICSC 1117 951 ICSC IARC 60 Cat. 3) (GHS if inhaled Toxic a fumigant – classified as

50 132- 1500 1830 1200 180 500 LD mg/kg 95 300- 1000 1820 925 237 435 1644 500- 1000 820 769 320 62 1360 1670 1012 3 3 4 3 4 4 4 4 4 3 4 4 4 3 4 4 4 4 3 4 GHS I I I I I I I I F F F H H H H H H H AC FM use Main L S L L L L L L S S S S S S S S S S S S Phys Phys state T C TC OP OP OP OP type Chem Chem no UN 1690 1280 1495 2757 2783 2588 3018 2784 71561-11-0  96489-71-3  119-12-0  2797-51-5  76578-12-6  119738-06-6  83-79-4  1014-70-6  7775-09-9  7681-49-4  118134-30-8  CAS no  114-26-1  75-56-9  52888-80-9  34643-46-4  77458-01-6  13457-18-6  8003-34-7  57369-32-1  13593-03-8  [C] Common name Common [ISO] Propoxur [ISO] oxide Propylene [ISO] Pyrazoxyfen [C]Pyrethrins Pyridaben [ISO] Pyridaphenthion [ISO] Pyroquilon Quinalphos [ISO] Quinoclamine [ISO] Quizalofop Quizalofop-p-tefuryl [ISO] [C]Rotenone Simetryn [ISO] Sodium chlorate Sodium[C] fluoride [ISO] Spiroxamine Prosulfocarb [ISO] Prosulfocarb [ISO] Prothiofos [ISO] Pyraclofos [ISO] Pyrazophos Table 3. Moderately hazardous (Class II) technical grade active ingredients in pesticides (cont.) active ingredients grade II) technical (Class hazardous 3. Moderately Table

Table 3. Moderately hazardous (Class II) technical grade active ingredients in pesticides 37 ; ICSC 757 ; (Group 3) (Group

53 ICSC 586 , ; IARC 12 ; 2004 2004 2010 EHC 78 , , , See 3; note JMPR 1992 JMPR 1985 JMPR 1989 Remarks JMPR 1994 JMPR 2006 JMPR 2010 thiocyclam to oxalate Refers JMPR 2000 Irritant to skinIrritant to and eyes JMPR 2011 48 4, p. Table See 8 to note

50 602 595 644 483 396 871 278 1300 310 66 560 934 c85 900 LD mg/kg 850 543 1700 1031 1000 1500 400 4 3 4 4 4 4 3 4 4 4 4 4 4 4 4 4 3 4 4 4 4 GHS I I I I I I I F F F F H H H H H H H MT FST use Main S S S L S S S S S S S S S S S S S S S oil Oil Phys Phys state T C TC PY type Chem Chem no UN 2757 3349 1839 43121-43-3  55219-65-3  119168-77-3  34014-18-1  33693-04-8  112281-77-3  111988-49-9  153719-23-4  25366-23-8  28249-77-6  31895-22-4  59669-26-0  137-26-8  87820-88-0  66841-25-6  CAS no  95-06-7  4151-50-2  946578-00-3  50-31-7  76-03-9  107534-96-3  Tralkoxydim [ISO] Tralkoxydim Tralomethrin [ISO] Triadimefon [ISO] Triadimenol Common name Common [ISO] Sulfallate [ISO] Tebufenpyrad [ISO] Tebuthiuron [ISO] Terbumeton [ISO] Tetraconazole Thiacloprid [ISO] Thiamethoxam [ISO] Thiazafluron [ISO] Thiobencarb Thiocyclam [ISO] [ISO] Thiodicarb [ISO] Thiram Sulfluramid [ISO] Sulfluramid [ISO*] Sulfoxaflor [ISO] 2,3,6-TBA (acid) [ISO] TCA [ISO] Tebuconazole Table 3. Moderately hazardous (Class II) technical grade active ingredients in pesticides (cont.) active ingredients grade II) technical (Class hazardous 3. Moderately Table

38 The WHO Recommended Classification of Pesticides by Hazard . 2003 , ; Table 7, p. 65 7, p. Table , Suppl 7 is regulated by the by is regulated (Group 3) (Group

53 JECFA 2000b JECFA , ; IARC 30 and trichlorfon IARC 12

; JMPR 1978 ; HSG 66; ; EHC 78 EHC 132

ICSC 585 JMPR 1996 ; ; tributyltin compounds Remarks See 3; note 3) (Group ICSC 1252 Irritant skin; to ICSC 348

50 250 LD mg/kg 50-100 710 305 650 695 1790 1780 542 380 1400 4 3 3 4 4 4 4 4 4 4 4 GHS Gamma-HCH (lindane) and HCH (specifically alpha-HCH and beta-HCH) are strictlyGamma-HCH (lindane) and HCH (specifically alpha-HCH beta-HCH) are ), which entered into force on 17 May, 2004 and has subsequently been amended. 2004 and has subsequently on 17 May, force into ), which entered I I I F F F F H H AP use PGR Main L S S S S S S S S S Oil Phys Phys state http://www.pops.int/ ), which entered into force on 24 February 2004 and has subsequently been amended. See been amended. 2004 and has subsequently on 24 February force into ), which entered and its related isomers, isomers, and its related

C C TC OP type Chem Chem Gamma-HCH thiram, (lindane), HCH, mercury compounds, no UN 2588 http://www.pic.int/ technical endosulfan technical endosulfan,

dicofol, 52-68-6  81412-43-3  1929-77-7  CAS no  112143-82-5  55335-06-3  41814-78-2  99387-89-0  83657-22-1  2655-14-3  2425-10-7  137-30-4  chlordane, DDT, DDT, chlordane, alachlor, varies according to the mixture of isomers. The value shown has been chosen, and the technical product placed in Class II, as a result of the cumulative properties of the cumulative in Class II, as a result product placed has been chosen, and the technical shown value The the mixture of isomers. to according varies 50 relevant to humans. to relevant (see Informed Consent on Prior Convention Rotterdam (see pollutants organic on persistent the Stockholm by Convention limited beta isomer. Alachlor was previously classified as a Class Ia pesticide due to its carcinogenicity in rats. However mechanistic studies have indicated that tumors are induced by a mechanism not induced tumors are that indicated mechanistic studies have However rats. in to its carcinogenicity classified as a Class Ia pesticide due previously was Alachlor of isomers. concentrations to according within this series, varies considerably members of a series; their toxicity and esdepalléthrineBioallethrin, are esbiothrin, esbiol, of trade international The DDT, production and use of chlordane, The HCH: The LD isothiocyanate (S) is 35°C. of methyl melting point The Common name Common [ISO] Triazamate [ISO] Trichlorfon [ISO] Triclopyr [ISO] Tricyclazole [ISO] Tridemorph Triflumizole [ISO] Uniconazole [ISO] Vernolate XMC Xylylcarb [ISO] Ziram Table 3. Moderately hazardous (Class II) technical grade active ingredients in pesticides (cont.) active ingredients grade II) technical (Class hazardous 3. Moderately Table Risks Humans; ICSC = International to of Carcinogenic Guide; IARC on the Evaluation HSG = Health and Safety = IARC Monograph; Monographs Health Criteria EHC = Environmental Residues; Meeting Pesticide on FAO/WHO Joint the by Evaluation = JMPR Additives; Expert Food on Committee FAO/WHO Joint the by Evaluation = JECFA Card; Safety Chemical Specifications. Meeting on Pesticide FAO/WHO the Joint by JMPS = Evaluation II Class to Notes 1. 2. 3. 4. 5. 6.

Table 3. Moderately hazardous (Class II) technical grade active ingredients in pesticides 39 May value listed listed value 50 , and the Annex Pages 8 & 9 Pages See DEPENDS ON ITS FORMULATION DEPENDS ON ITS value chosen for classification purposes is generally based on administration in corn oil and can be much lower than that much lower can be corn oil and in based on administration purposes is generally chosen for classification value 50 THE FINAL CLASSIFICATION OF ANY PRODUCT OF ANY THE FINAL CLASSIFICATION and other flowers. . spp. values. The single LD The values. 50 Lonchocarpus Lonchocarpus Pyrethrum cineraefolium Pyrethrum cineraefolium and Derris values of <50 mg/kg have sometimes been recorded with lambda-cyhalothrin in studies in mice, but in the context that toxicity data for pyrethroids are highly variable, the LD highly variable, are with lambda-cyhalothrin data for pyrethroids that toxicity sometimes been but in the context recorded have of <50 mg/kg in studies mice, values 50 The toxicity data for pyrethroids is highly variable according to isomer ratios, the vehicle used for oral administration, and the husbandry of the test animals e.g. fasting prior to dosing. The The dosing. prior to fasting and the husbandry animals e.g. administration, of the test used for oral the vehicle isomer ratios, to according is highly variable data for pyrethroids toxicity The LD ‘c’ before in the prefix is reflected variability reflect to true hazard. is if the classification by formulation underlines the need for classification This in aqueous solutions. LD has been used as the basis for classification. 2007 – based on data in rats) the JMPR (JMPR end-point by as the critical (JMPR 2018). conducted with an 80% formulation based on a study toxicity, oral acute to be of moderate considered upon and that norflurazonnot be should relied be No WHO evaluations are available, but detailed evaluations of classification are available from stringent regulatory stringent from authorities. available are of classification but detailed evaluations available, are No WHO evaluations (2003)). Manual Pesticides The (see for example hazard moderate indicate Publications available. are No WHO evaluations could contradictory results showing concluded that older studies with this substance evaluation A subsequent JMPR hazard”. present acute to “Unlikely as classified was previous Norflurazon fatality 2010). has been (Dawson reported with this substance A high case et al, in poisoning cases be used as paraquat dichloride (CAS number 1910-42-5) number dichloride (CAS be used as paraquat Paraquat has serious delayed effects if absorbed. It is of relatively low hazard in normal use but may be fatal if the concentrated product is taken by mouth or spread on the skin. the on spread or mouth by product taken is concentrated the if fatal be normal in may but use hazard low relatively absorbed. if effects of is It serioushas delayed Paraquat in Mixture present of compounds of roots from Compounds

Table 3. Moderately hazardous (Class II) technical grade active ingredients in pesticides (cont.) active ingredients grade II) technical (Class hazardous 3. Moderately Table 7. 8. 9. 10. 11. 12. 13. 14. 15.

40 The WHO Recommended Classification of Pesticides by Hazard ICSC 99 ; JMPR 1989 (Group 3) (Group , 73 2005 2008 , , IARC 53 Remarks JMPR 2012 and skin; eyes Irritant to HSG 47; EHC 217 JMPR 1987 Irritant skin to and eyes ICSC 106 ICSC 567 JMPR 1991 JMPR 1987 mg/ 50 LD kg 2950 2260 4500 4000 c2000 4200 2031 c4000 2200 >4000 2500 >2000 3900 2710 >4000 3200 3280 2635 4500 3300 3820 2420 GHS 5 5 5 5 5 4 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 Main use H H F PGR H H F H F H F I F AC,F H F I H F H FST H Phys Phys state L S S S S S S S S S S S S S S S S L L S S S Chem Chem type T TC T UN no CAS no  34256-82-1  55634-91-8  12771-68-5  3337-71-1  1912-24-9  71626-11-4  68505-69-1  41483-43-6  69327-76-0  2008-41-5  2439-01-2  865318-97-4  7773-06-0  101-05-3  68038-71-1  3813-05-6  92-52-4  125401-75-4  1303-96-4  23184-66-9  5234-68-4  1698-60-8  (Bt) Common name Common [ISO] Acetochlor Alloxydim [ISO*] Ametoctradin sulfamate Ammonium Ancymidol [ISO] Anilazine [ISO] [ISO] Asulam [ISO] Atrazine Bacillus thuringiensis Benalaxyl [ISO] [ISO] Benazolin Benfuresate Biphenyl Bispyribac [ISO] Borax [ISO] Bupirimate [ISO] Buprofezin Butachlor [ISO] Butylate [ISO] Carboxin [ISO] Chinomethionat [ISO] Chloridazon Table 4. Slightly hazardous (Class III) technical active grade ingredients III) 4. in pesticides Slightly hazardous (Class Table

Table 4. Slightly hazardous (Class III) technical grade active ingredients in pesticides 41 ICSC 443 2009 JMPR 2001 , 2001 2005 2009 2006 , , , , JMPR 1998 ; ; HSG 99; Remarks JMPR 1992 ISO Chlorthal 2136-79-0) is an approved (with CAS no. name common JMPR 1986 eyes; irritant to Severe JMPR 2017 JMPR 1992 JMPR 2014 JMPR 1999 ICSC 867 ICSC 871 inhalation; skin sensitiser by toxic Acutely EHC 184 mg/ 50 LD kg 4102 >4000 >3200 4300 >2000 3300 3160 3160 c2000 >2000 >3000 >3000 >3000 3960 >2000 3900 >2000 2068 2080 4000 >4640 GHS 5 5 5 5 5 5 5 5 5 5 5 4 5 5 5 5 5 5 5 5 5 Main use H F AC H I H AC L H F AC RP H H I H H H AC H L Phys Phys state S S S S S L S S L S S S S S L S S L S S Chem Chem type OC OP TC UN no CAS no  99283-00-8  84332-86-5  74115-24-5  1702-17-6  1031756-98-5  400882-07-7  66215-27-8  1194-65-6  2227-17-0  134-62-3  83164-33-4  1982-47-4  5598-13-0  1861-32-1  87818-31-3  1134-23-2  101205-02-1  80060-09-9  37764-25-3  99-30-9  35367-38-5  Common name Common Chlorimuron Chloroxuron [ISO] Chloroxuron [ISO] methyl Chlorpyrifos Chlorthal-dimethyl Chlozolinate Cinmethylin [ISO] Clofentezine [ISO] Clopyralid Cyclaniliprole [ISO] Cycloate Cycloxydim [ISO] Cyflumetofen Cyromazine [ISO] Diafenthiuron Dichlobenil [ISO] Dichlormid Dicloran Dienochlor [ISO] Diethyltoluamide Diflubenzuron [ISO] Diflufenican Table 4. Slightly hazardous (Class III) technical grade active ingredients in pesticides (cont.) active ingredients grade III) technical (Class hazardous 4. Slightly Table

42 The WHO Recommended Classification of Pesticides by Hazard 2016 , 2004 , 2015 2012 2001 , , , JMPR 1992 ; JMPR 2007 JMPR 2012 Skin irritant and eye JMPR 2002 JMPR 2010 JMPR 2013 JMPR 1995 JMPR 1997 EHC 15 JMPS 2010 JMPR 2018 JMPR 1994 Remarks mg/ 50 3500 3000 2450 3400 >2000 D>2000 >2000 2500 >2000 2630 3150-4000 >2000 LD kg >2000 3000 2350 4500 >2280 >4000 2000 2350 3515 5 5 5 5 5 5 5 5 5 5 5 5 4 5 5 5 5 5 5 5 5 GHS H H F F H I H H I H PGR AC F F F F MT H H F F Main use Phys Phys state S L S S S S S L Oil L S S L S S S S S S oil TC OT Chem Chem type T PY UN no 22936-75-0  5221-53-4  110488-70-5  29091-05-2  165252-70-0  330-54-1  1593-77-7  54406-48-3  85785-20-2  16672-87-0  153233-91-1  2593-15-9  161326-34-7  60168-88-9  114369-43-6  13356-08-6  66441-23-4  71283-80-2  517875-34-2  67564-91-4  CAS no  34205-21-5  Common name Common [ISO] Dimefuron Dimethametryn [ISO] Dimethirimol Dimethomorph [ISO] [ISO] Dinitramine [ISO] Dinotefuran [ISO] Diuron Dodemorph [ISO] [(1R) isomers] Empenthrin [ISO] [ISO] Esprocarb Ethephon [ISO] Etoxazole [ISO] Etridiazole [ISO] Fenamidone [ISO] Fenarimol Fenbuconazole [ISO] oxide Fenbutatin [ISO] Fenoxaprop-ethyl [(ISO)] Fenoxaprop-p-ethyl [ISO*] Fenpicoxamid Fenpropimorph Table 4. Slightly hazardous (Class III) technical grade active ingredients in pesticides (cont.) active ingredients grade III) technical (Class hazardous 4. Slightly Table

Table 4. Slightly hazardous (Class III) technical grade active ingredients in pesticides 43 , JMPR 1986 ; ICSC 160

(Group 2A) (Group 2016 , IARC 112 , 2011 , Remarks JMPR 2017 JMPS 2013 JMPR 2010 JMPR 2015 JMPR 2010 See 1; EFSA 2014b note Skin irritant and eye JMPR 2012 EHC 159 2004 JMPR 1990 JMPR 2014 JMPR 2013 JMPR 1995 mg/ 50 LD kg >2000 >3000 3000 4000 4230 2180 3900 3500 D>2000 2451 >2000 >3000 D>2000 >2000 >2000 >3000 >2000 2400 2850 D>4000 D>2000 GHS 5 5 5 4 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 Main use F F H I AC I I F H F I F H I F FST H H F H H Phys Phys state S S S L S S S S S S S oil S S S S S S S S S Chem Chem type PY PZ OP UN no CAS no  473798-59-3  90134-59-1  104040-78-0  272451-65-7  37893-02-0  658066-35-4  61213-25-0  907204-31-3  1071-83-6  112226-61-6  79983-71-4  10004-44-1  104098-48-8  36734-19-7  79241-46-6  101463-69-8  103361-09-7  958647-10-4  102851-06-9  25954-13-6  114311-32-9  Common name Common [ISO*] Fenpyrazamine Flamprop-M Flazasulfuron [ISO] Flazasulfuron Fluazifop-p-butyl [ISO] [ISO] Flubendiamide [ISO] Flubenzimine Flufenoxuron [ISO] Flumioxazin [ISO] Fluopyram Flurochloridone [ISO*] Flutianil tau-Fluvalinate [ISO*] Fluxapyroxad [ISO] Fosamine [ISO] Glyphosate Halofenozide Hexaconazole Hymexazol [ISO] Imazamox Imazapic [ISO] Iprodione [ISO] Table 4. Slightly hazardous (Class III) technical grade active ingredients in pesticides (cont.) active ingredients grade III) technical (Class hazardous 4. Slightly Table

44 The WHO Recommended Classification of Pesticides by Hazard , JMPR 1997 ; ICSC 172 ; (Group 2A) (Group IARC 112 JMPR 2013 2016 , Remarks See 2; note JMPR 2018 ICSC 1300 JMPR 2015 See 3; note 2003 JMPR 2018 JMPR 2010 JMPR 2014 Sheet 2006 Fact Pesticide EPA See 1; US note ICSC 1360 ICSC 1273 mg/ 50 LD kg D>2000 >2000 4000 >2000 >2500 3948 2780 >3200 2250 c3000 >2000 c2100 >2000 D>2000 2150 2500 >2000 >4000 c3000 2800 GHS 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 Main use H F H I F F H H H I H H H PGR H I H H H SY Phys Phys state S S S L L S S S S S L L S S S S S L Chem Chem type NP OP PY UN no 3082 3013 CAS no  141112-29-0  143390-89-0  330-55-2  173662-97-0  131-72-6  104206-82-8  18691-97-9  42609-73-4  240494-70-6  51218-45-2  19937-59-8  1746-81-2  1836-75-5  103055-07-8  121-75-5  67129-08-2  3060-89-7  7287-36-7  86-87-3  113-48-4  Common name Common [ISO] Isoxaflutole [ISO] Kresoxim-methyl [ISO] Linuron Lufenuron [ISO] Lufenuron Malathion [ISO] [ISO*] Mandestrobin [ISO] Meptyldinocap Mesotrione [ISO] Metazachlor [ISO] Methabenzthiazuron Methyldymron [ISO] Metobromuron [ISO] Metofluthrin Metolachlor [ISO] Metoxuron Monalide [ISO] Monolinuron acid 1-Naphthylacetic [ISO] Nitrofen N-octylbicycloheptene [C] dicarboximide Table 4. Slightly hazardous (Class III) technical grade active ingredients in pesticides (cont.) active ingredients grade III) technical (Class hazardous 4. Slightly Table

Table 4. Slightly hazardous (Class III) technical grade active ingredients in pesticides 45 JMPR 1999 ICSC 324 ; ; HSG 25; ICSC 669 ; 2015 JMPR 2017 EHC 92 , ; Eye irritant; May cause respiratory irritation; respiratory irritant; May cause ; Eye (Group 3) (Group

Remarks JMPR 1992 JMPR 2011 IARC 73 JMPR 2012 See 4; note JMPR 2016 skin sensitization May cause JMPR 1999 JMPR 2014 JMPR 2007 JMPR 2018 Sheet 2008 Fact Pesticide EPA See 1; EFSA 2013; US note See 5; note mg/ 50 LD kg 2600 2120 >2000 2980 3150 2200 2900 2680 2000 >2000 2480 D>2000 D>2000 2030 D>2000 c2000 4150 >2000 3200 >2000 2000 GHS 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 4 5 5 5 4 Main use F F F F F F H H H AC I F F H H H F F H F I Phys Phys state S S S S S S S S S S S L S S L S S S S S Chem Chem type T T PZ PZ PY UN no CAS no  58810-48-3  66246-88-6  90-43-7  117428-22-5  7681-93-8  243973-20-8  1610-18-0  7287-19-6  2312-35-8  123312-89-0  88283-41-4  688046-61-9  422556-08-9  84087-01-4  5259-88-1  183675-82-3  27605-76-1  55512-33-9  53112-28-0  123343-16-8  10453-86-8  Common name Common Ofurace Oxycarboxin [ISO] Oxycarboxin Penconazole [ISO] Penthiopyrad [C] 2-Phenylphenol [ISO] Picoxystrobin Pimaricin [ISO] Pinoxaden Probenazole [ISO] Prometon [ISO] Prometryn [ISO] Propargite Pymetrozine [ISO] [ISO] Pyridate [ISO] Pyrifenox Pyrimethanil [ISO] Pyriofenone [ISO*] Pyrithiobac sodium [ISO] Pyroxsulam [ISO] Quinclorac Resmethrin [ISO] Table 4. Slightly hazardous (Class III) technical grade active ingredients in pesticides (cont.) active ingredients grade III) technical (Class hazardous 4. Slightly Table

46 The WHO Recommended Classification of Pesticides by Hazard JMPR 2009 ICSC 1502 ; ; Irritant skin to and eyes JMPR 2001 2002 ICSC 1139 , JMPR 2013 JMPR 2006 ; ; (Group 2B) (Group ICSC 201 Remarks JMPR 2011 131929-60-7 CAS numbers are Spinosyn A and D, For and 131929-63-0; effects; carcinogenic See 6 regarding note JMPR 2008 See 7; Skin note irritant.; membrane and mucous ICSC 1166 See 8; note ICSC 199 IARC 112 1997 JECFA HSG 89; ICSC 202 JMPR 2017 1268 ICSC mg/ 50 LD kg >2000 3200 3200 4000 2160 4000 >4000 2165 >4930 2500 3738 D>2000 >2000 >3000 2400 3330 2830 >2000 >2000 GHS 5 5 5 5 4 5 5 5 5 5 5 5 5 4 5 5 5 5 5 Main use H H I AC I F,I H I H I PGR H I F RP H F H PGR Phys Phys state S L S S S S S L S S S S S L S L S Oil Chem Chem type OP T OP TC T T UN no 1350 CAS no  372137-35-4  74051-80-2  148477-71-8  650-51-1  3383-96-8  5915-41-3  22248-79-9  51707-55-2  2303-17-5  1263133-33-0  112-12-9  168316-95-8  203313-25-1  7704-34-9  886-50-0  148-79-8  1912-26-1  95266-40-3  131983-72-7  Common name Common Saflufenacil [ISO] [ISO] Sethoxydim Spinosad [ISO] [ISO] Spirodiclofen [ISO] Spirotetramat Sulphur (sodium salt) [ISO] TCA [ISO] Temephos [ISO] Terbuthylazine [ISO] Terbutryn [ISO] Tetrachlorvinphos [ISO] Thiabendazole Thidiazuron [ISO] Tri-allate [ISO] Trietazine [ISO*] Triflumezopyrim [ISO] Trinexapac-ethyl [ISO] Triticonazole Undecan-2-one [C] Table 4. Slightly hazardous (Class III) technical grade active ingredients in pesticides (cont.) active ingredients grade III) technical (Class hazardous 4. Slightly Table

Table 4. Slightly hazardous (Class III) technical grade active ingredients in pesticides 47 of 400 mg/ of 50 , and the Annex Pages 8 & 9 Pages See DEPENDS ON ITS FORMULATION DEPENDS ON ITS THE FINAL CLASSIFICATION OF ANY PRODUCT OF ANY THE FINAL CLASSIFICATION >7000 mg/kg) and appears in Table 5. Table >7000 mg/kg) and appears in 50 value can vary according to impurities. This value has been adopted for classification purposes and is that of a technical product conforming to WHO specifications. to conforming technical product of a purposes classification and is that for has been adopted value This impurities. to can vary value according 50 No WHO evaluations are available, but detailed evaluations of classification are available from stringent regulatory stringent from authorities. available are of classification but detailed evaluations available, are No WHO evaluations (JMPR 2013). the diet humans from to risk carcinogenic to pose a but unlikely rats, and in mice carcinogenic is that isoxaflutole JMPR concluded LD (oral toxicity for Risk Union Committee European 2009). The the diet (JMPR from humans risk to pose a carcinogenic to but unlikely and rats, in mice is carcinogenic that spirodiclofen JMPR concluded to the GHS (ECHA 2016b). Category should beAssessmentCarcinogenicity classified as that spirodiclofen (RAC) 1B for (H350) according concluded skin. to in Class II. It be placed is highly corrosive and if used as a pesticide would kg bw Malathion: LD and natamycin. with tennecetin identical antibiotic, Pimaricin: isomer (70-80%) also being known alone is of much lower and the cis isomer (20-30%) as cismethrin. the trans Resmethrin Bioresmethrin as bioresmethrin is a mixture of isomers, about 50% with inert unless diluted ignite Sulphur dust can spontaneously material. LD oral with an this is a solid ISO): by accepted acid (now the free to (TCA)term the same refers countries, In many acid. trichloroacetic sodium to refer shown data The TCA: Table 4. Slightly hazardous (Class III) technical grade active ingredients in pesticides (cont.) active ingredients grade III) technical (Class hazardous 4. Slightly Table Risks Humans; ICSC = International to of Carcinogenic Guide; IARC on the Evaluation HSG = Health and Safety = IARC Monograph; Monographs Health Criteria EHC = Environmental Residues; Meeting Pesticide on FAO/WHO Joint the by Evaluation = JMPR Additives; Expert Food on Committee FAO/WHO Joint the by Evaluation = JECFA Card; Safety Chemical Specifications. Meeting on Pesticide FAO/WHO the Joint by JMPS = Evaluation III Class to Notes 1. 2. 3. 4. 5. 6. 7. 8.

48 The WHO Recommended Classification of Pesticides by Hazard ; JMPR 1995 ; ICSC 631 ; ICSC 382 Group 3) Group JMPR 1991 ( ; , HSG 81; IARC 79 ICSC 229 EHC 148 , HSG 85; ; HSG 25; Remarks JMPR 2014 JMPR 2007 Sheet 2011 Fact Pesticide EPA See 1; EFSA 2014a; US note EHC 158 JMPR 1997 ICSC 1605 JMPR 2008 JMPR 2017 See 2; note as such but molecule is not an active substance This is a “safener” JMPR 2006 EHC 92 JMPR 1998 JMPR 2006

50 LD mg/kg >5000 >5000 >5000 >5000 >5000 5000 >5000 >5000 >5000 >5000 >10000 6400 >10000 >5000 >5000 >5000 >6400 >7000 >5000 >5000 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 GHS I F F F F F F H H H H H H H H H H RP AC MT use Main S S S L S S S S S S S S S S S S S S S Phys Phys state PY PY type Chem Chem no UN CAS no  74070-46-5  101007-06-1  858956-08-8  150114-71-9  348635-87-0  61-82-5  84-65-1  120162-55-2  131860-33-8  352010-68-5  1861-40-1  15310-01-7  17804-35-2  98730-04-2  83055-99-6  149877-41-8  42576-02-3  28434-01-7  55179-31-2  188425-85-6  Common name Common Aclonifen [ISO] Acrinathrin [ISO*] Aminocyclopyrachlor [ISO] Aminopyralid Amisulbrom [ISO] [ISO] Amitrole Anthraquinone Azimsulfuron [ISO] [ISO] Azoxystrobin [ISO*] Bicyclopyrone [ISO] Benfluralin Benodanil [ISO] [ISO] Benomyl [ISO] Benoxacor Bensulfuron-methyl [ISO] Bifenazate [ISO] Bifenox [ISO] Bioresmethrin Bitertanol Boscalid [ISO] Table 5. Technical grade active grade ingredients of pesticides to present unlikely acute hazard Technical in use normal 5. Table

Table 5. Technical grade active ingredients of pesticides unlikely to present acute hazard in normal use 49 ); 2005 ; , Group 3 Group 1998 , ICSC 134 ; , Suppl 7 ( JMPR 2000 JMPR 1995 ; ; 2007 , (Group 2B) (Group IARC 30 73 2004 , ICSC 1500 ICSC 1277 IARC ); JMPR 1995 Group 3 Group ; ; HSG 82; ; HSG 98; ( Remarks ICSC 1448 JMPR 1993 Irritant skin; to HSG 50; ICSC 120 EHC 149 JMPR 2008 EHC 183 JMPR 1992 ICSC 1327 IARC 12 JMPR 2013

50 LD mg/kg 5200 >5000 >5000 9000 >10000 >10000 >5000 >5000 >5000 8500 >10000 >10000 >10000 >10000 >5000 5545 >5000 >5000 >5000 >10000 >5000 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 GHS I I I F F F F H H H H H H H H H AC IGR use PGR PGR PGR Main S S S L S S S S S S S S S S S S S S S S S Phys Phys state C C PZ OC OC PAA type Chem Chem no UN CAS no  314-40-9  74712-19-9  18181-80-1  133-06-2  10605-21-7  16118-49-3  104030-54-8  14750-35-4  500008-45-7  71422-67-8  2464-37-1  2675-77-6  1897-45-6  15545-48-9  101-21-3  64902-72-3  94593-91-6  84496-56-0  32791-87-0  15096-52-3  736994-63-1  Common name Common [ISO] Bromacil Bromobutide [ISO] Bromopropylate [ISO] Captan [ISO] Carbendazim [ISO] Carbetamide [ISO] Carpropamid methyl Chloransulam [ISO] Chlorantraniliprole Chlorfluazuron Chlorflurenol [ISO] [ISO] Chloroneb [ISO] Chlorothalonil [ISO] Chlorotoluron [ISO] Chlorpropham Chlorsulfuron [ISO] Cinosulfuron Clomeprop Cloxyfonac Cryolite [C] [ISO*] Cyantraniliprole Table 5. Technical grade active ingredients of pesticides unlikely to present acute hazard in normal use (cont.) hazard acute present to of pesticides unlikely active ingredients grade Technical 5. Table

50 The WHO Recommended Classification of Pesticides by Hazard Remarks JMPR 2015 JMPR 1991 JMPR 1983 ICSC 261 JMPR 2018

50 LD mg/kg >5000 >5000 >5000 >5000 >5000 9330 8400 >9600 >5000 >10000 >5000 >5000 >10000 8200 5230 >5000 >10000 >7080 6340 >6400 >5000 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 GHS I I F F F F H H H H H H H H H H RP RP RP FST use PGR Main S L L L L S S S S S S S S S S S S S S S Phys Phys state PY type Chem Chem no UN CAS no  120116-88-3  63935-38-6  136849-15-5  122008-85-9  42609-52-9  75-99-0  1596-84-5  13684-56-5  1085-98-9  62865-36-5  145701-21-9  87130-20-9  18467-77-1  131-11-3  3737-22-2  97886-45-8  55283-68-6  181587-01-9  23947-60-6  26225-79-6  52304-36-6  Common name Common [ISO] Cyazofamid Cycloprothrin [ISO(*)] Cyclosulfamuron [ISO] Cyhalofop Daimuron Dalapon [ISO] Daminozide Desmedipham [ISO] Dichlofluanid [ISO] Diclomezine Diclosulam [ISO] Diethofencarb Dikegulac [ISO] [C] phthalate Dimethyl [C] isocinchomerate Dipropyl [ISO] Dithiopyr [ISO] Ethalfluralin [ISO] Ethiprole Ethirimol [ISO] [ISO] Ethofumesate Ethyl butylacetylaminopropionate Table 5. Technical grade active ingredients of pesticides unlikely to present acute hazard in normal use (cont.) hazard acute present to of pesticides unlikely active ingredients grade Technical 5. Table

Table 5. Technical grade active ingredients of pesticides unlikely to present acute hazard in normal use 51 JMPR 1996 ; ICSC 792 ); Group 3 Group ( 2011 , IARC 12 ; Remarks JMPR 1993 JMPR 2003 “safener”. molecule is a herbicide This JMPR 2005 CAS RegistryThe formerly Number 79127-80-3 was used. EHC 78 JMPR 2004 JMPR 2009

50 LD mg/kg >10000 >5000 >5000 >5000 >10000 >5000 >10000 >5000 >10000 >5000 > 5000 >5000 >5000 >5000 >5000 >8000 >5000 9000 >10000 >5000 >5000 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 GHS I I F F F F F H H H H H H H H H AC FST FST use PGR PGR Main S S S S S S S S S S S S S S S S S S S S S Phys Phys state C type Chem Chem no UN CAS no  80844-07-1  131807-57-3  103112-36-3  3740-92-9  24691-80-3  126833-17-8  72490-01-8  74738-17-3  14484-64-1  145701-23-1  181274-17-9  113036-88-7  131341-86-1  62924-70-3  98967-40-9  2164-17-2  239110-15-7  15457-05-3  756-09-2  144740-54-5  467-69-6  Common name Common Etofenprox [ISO] Famoxadone [ISO] Fenchlorazole Fenclorim [ISO] Fenfuram [ISO] Fenhexamid Fenoxycarb Fenpiclonil [ISO] Ferbam Florasulam Flucarbazone-sodium [ISO] Flucycloxuron [ISO] Fludioxonil Flumetralin [ISO] Flumetsulam [ISO] Fluometuron [ISO] Fluopicolide [ISO] Fluorodifen Flupropanate [ISO] Flupyrsulfuron [ISO] Flurenol Table 5. Technical grade active ingredients of pesticides unlikely to present acute hazard in normal use (cont.) hazard acute present to of pesticides unlikely active ingredients grade Technical 5. Table

52 The WHO Recommended Classification of Pesticides by Hazard 2007 , 2004 , JMPR 1995 ; 2008 JMPR 2002 , ; ICSC 156 Remarks ICSC 1265 HSG 72; JMPR 2017 ICSC 1266 JMPR 1991 Irritant eyes to

50 LD mg/kg >10000 >5000 >5000 >10000 >10000 5800 >2000 >10000 >5000 >5000 >10000 8530 >5000 >5000 >5000 >5000 >5000 >10000 >5000 >10000 >10000 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 GHS I F F F F F F F H H H H H H H H RP AC IGR use PGR PGR Main S L L S S S S S S S S S S S S S S S S S S Phys Phys state type Chem Chem no UN CAS no  59756-60-4  69377-81-7  149253-65-6  66332-96-5  133-07-3  15845-66-2  39148-24-8  77-06-5  86479-06-3  78587-05-0  41096-46-2  3547-33-9  81405-85-8  81334-34-1  81335-37-7  81335-77-5  86598-92-7  82211-24-3  140923-17-7  82558-50-7  19408-46-9  Common name Common [ISO] Fluridone Fluroxypyr Fluthiacet Flutolanil Folpet Fosetyl Fosetyl-aluminium acid Gibberellic [ISO] Hexaflumuron Hexythiazox [ISO] Hydroprene octyl 2-Hydroxyethyl sulphide [C] Imazamethabenzmethyl [(ISO)] Imazapyr Imazaquin Imazethapyr [ISO] Imibenconazole Inabenfide Iprovalicarb Isoxaben Kasugamycin Table 5. Technical grade active ingredients of pesticides unlikely to present acute hazard in normal use (cont.) hazard acute present to of pesticides unlikely active ingredients grade Technical 5. Table

Table 5. Technical grade active ingredients of pesticides unlikely to present acute hazard in normal use 53 ; ; EHC 78 EHC 78 JMPR 1977 ; JMPR 2003 ICSC 1306 ; JMPR 1996 ); > 5000; 2001 , 50 JMPR 1993 JMPR 1993 ; ; (Group 3) (Group

Group 3 Group ( Remarks IARC 4 Irritant skin to on multiple exposure; ICSC 754 JMPR 2008 Irritant skin to on multiple exposure; ICSC 173 JMPR 2009 JMPR 1987 IARC 20 Dermal LD JMPR 1993 JMPR 2014

50 LD mg/kg >10000 6950 >8000 >5000 6750 >5000 >5000 >10000 >5000 >10000 6000 >5000 >10000 >5000 >5000 >5000 6400 5000 8200 >10000 5000 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 GHS I I I F F F F F F F H H H H H H M IGR use PGR PGR PGR Main S S L S S S S S S S S S S S S S S S S S S Phys Phys state OC type Chem Chem no UN 2210 CAS no  2164-08-1  123-33-1  8018-01-7  374726-62-2  12427-38-2  73250-68-7  110235-47-7  55814-41-0  139968-49-3  40596-69-8  72-43-5  161050-58-4  9006-42-2  139528-85-1  220899-03-6  74223-64-6  86-86-2  15299-99-7  132-66-1  555-37-3  50-65-7  Common name Common [ISO] Lenacil [C] Maleic hydrazide Mancozeb [ISO] Mandipropamid Maneb [ISO] Mefenacet Mepanipyrim [ISO] [ISO] Mepronil [ISO] Metaflumizone [ISO] Methoprene [ISO] Methoxychlor Methozyfenozide Metiram Metosulam [ISO] Metrafenone methyl Metsulfuron acetamide 2-(1-Naphthyl) Napropamide Naptalam [ISO] Neburon Niclosamide [ISO] Table 5. Technical grade active ingredients of pesticides unlikely to present acute hazard in normal use (cont.) hazard acute present to of pesticides unlikely active ingredients grade Technical 5. Table

54 The WHO Recommended Classification of Pesticides by Hazard ICSC 1347 ; JMPR 1988 ; JMPR 1995 ; ICSC 313 > 5000 > 5000 2007 , 50 50 (Group 3) (Group

; HSG 32; Remarks Irritant eyes to JMPR 2005 Dermal LD Dermal LD EHC 96 ICSC 1246 IARC 30 JMPR 1989

50 LD mg/kg >5000 6400 >5000 >5000 >10000 >5000 >8000 7792 >5000 >5000 >5000 >10000 >8000 >5000 >5000 >10000 8200 >7500 6100 >5050 6800 >5000 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 GHS I I I F F F F F F H H H H H H H H H H H H SY use Main L L L S S S S S S S S S S S S S S S S S S Oil Phys Phys state PY CU type Chem Chem no UN CAS no  111991-09-4  10552-74-6  116714-46-6  121451-02-3  19044-88-3  74782-23-3  19666-30-9  10380-28-6  42874-03-3  66063-05-6  219714-96-2  2307-68-8  13684-63-4  26002-80-2  13598-36-2  27355-22-2  1918-02-1  51-03-6  51218-49-6  113036-87-6  32809-16-8  29091-21-2  Common name Common [ISO] Nicosulfuron [ISO] Nitrothal-isopropyl [ISO] Novaluron Noviflumuron Oryzalin [ISO] Oxabetrinil [ISO] Oxadiazon Oxine-copper [ISO] Oxyfluorfen [ISO] Pencycuron Penoxsulam Pentanochlor [ISO] Phenmedipham [ISO] Phenothrin acid [C] Phosphorus Phthalide [ISO] Picloram butoxide Piperonyl [ISO] Pretilachlor [ISO] Primisulfuron [ISO] Procymidone [ISO] Prodiamine Table 5. Technical grade active ingredients of pesticides unlikely to present acute hazard in normal use (cont.) hazard acute present to of pesticides unlikely active ingredients grade Technical 5. Table

Table 5. Technical grade active ingredients of pesticides unlikely to present acute hazard in normal use 55 JMPR 1995 ; ICSC 745 ; (Group 3) (Group

JMPR 1992 ; IARC 5 2005 JMPR 2001 , ; (Group 3) (Group JMPR 1993

; ; HSG 23; Remarks JMPR 1986 ICSC 1271 ICSC 697 IARC 12 EHC 78 JMPR 2008 JMPR 2018 ICSC 1269 JMPR 2006 EHC 41 JMPR 2012 See 3 note ICSC 699 JMPR 2008

50 LD mg/kg 8600 >5000 >5000 5000 8500 5620 >6200 >5000 9550 >5000 >5000 >5000 >5000 >5000 >10000 >5000 >5000 >7500 >5000 >5000 >5000 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 GHS I I I F F F F F F H H H H H H H H H H H H use Main L S S S S S S S S S S S S S S S S S S S Phys Phys state T T PZ PY type Chem Chem no UN CAS no  24579-73-5  111479-05-1  139-40-2  122-42-9  12071-83-9  23950-58-5  178928-70-6  1228284-64-7  58011-68-0  98389-04-9  136191-56-5  95737-68-1  90717-03-6  124495-18-7  82-68-8  122931-48-0  874967-67-6  1982-49-6  105024-66-6  122-34-9  187166-40-1  Common name Common Propamocarb Propaquizafop [ISO] Propazine [ISO] Propham [ISO] Propineb [ISO] Propyzamide [ISO] Prothioconazole Pydiflumetofen [ISO*] [ISO] Pyrazolynate [ISO] Pyrazosulfuron Pyriminobac [ISO] Pyriproxyfen [ISO] Quinmerac [ISO] Quinoxyfen [ISO] Quintozene Rimsulfuron [C] [ISO*] Sedaxane [ISO] Siduron Silafluofen [ISO] Simazine [ISO] [ISO] Spinetoram Table 5. Technical grade active ingredients of pesticides unlikely to present acute hazard in normal use (cont.) hazard acute present to of pesticides unlikely active ingredients grade Technical 5. Table

56 The WHO Recommended Classification of Pesticides by Hazard 2003 , 2017 , JMPR 1996 ICSC 205 2006 ; , JMPR 1994 ICSC 747 ICSC 334 > 5000; > 5000 2016 1998 2002 , , , 50 50 (Group 3) (Group

; HSG 12; ; HSG 11; ; HSG 31; Remarks Dermal LD EHC 42 JMPR 1994 EHC 67 EHC 98 Dermal LD JMPR 1995 JMPR 2018 JMPR 1994 JMPR 1988 JMPR 2004 IARC 53

50 LD mg/kg >5000 >5000 6210 >10000 >5000 >5000 >10000 >5000 >5000 >5000 >5000 10000 >5000 c5000 >5000 >5000 >5000 >5000 >5000 >5000 >10000 >5000 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 GHS I I I F F F F F N H H H H H H H H H O AC F-S use PGR Main L S S S S S S S S S S S S S S S S S S S Oil Phys Phys state TC PY PY type Chem Chem no UN CAS no  74223-56-6  112410-23-8  35256-85-0  117-18-0  83121-18-0  5902-51-2  116-29-0  7696-12-0  79277-27-3  130000-40-7  23564-05-8  36756-79-3  330459-31-9  57018-04-9  731-27-1  118712-89-3  82097-50-5  106040-48-6  141517-21-7  64628-44-0  1582-09-8  126535-15-7  Common name Common Sulfometuron Tebufenozide Tebutam [ISO] Tecnazene Teflubenzuron [ISO] Terbacil [ISO] Tetradifon [ISO] Tetramethrin Thifensulfuron-methyl Thifluzamide [ISO] Thiophanate-methyl Tiocarbazil [ISO*] Tioxazafen [ISO] Tolclofos-methyl [ISO] Tolylfluanid [ISO] Transfluthrin Triasulfuron [ISO] Tribenuron [ISO] Trifloxystrobin Triflumuron [ISO] Trifluralin [ISO] Triflusulfuron-methyl Table 5. Technical grade active ingredients of pesticides unlikely to present acute hazard in normal use (cont.) hazard acute present to of pesticides unlikely active ingredients grade Technical 5. Table

Table 5. Technical grade active ingredients of pesticides unlikely to present acute hazard in normal use 57 JMPR 1993 ; ICSC 350 ; (Group 3) (Group

2014 , ), which entered into force on 24 February 2004 and 2004 February 24 on force into entered which ), IARC 12 ; Remarks JMPR 1997 JMPR 1995 EHC 78 JMPR 2007

http://www.pic.int/ 50 LD mg/kg >6000 >10000 10000 >5000 >5000 5 5 5 5 5 GHS , and the Annex F F F F F use Main S S S S S Phys Phys state Pages 8 & 9 Pages See DEPENDS ON ITS FORMULATION DEPENDS ON ITS type Chem Chem THE FINAL CLASSIFICATION OF ANY PRODUCT OF ANY THE FINAL CLASSIFICATION no UN . Table 7, p. 65 7, p. Table CAS no  26644-46-2  37248-47-8  50471-44-8  12122-67-7  156052-68-5  No WHO evaluations are available, but detailed evaluations of classification are available from stringent regulatory stringent from authorities. available are of classification but detailed evaluations available, are No WHO evaluations – GHS category 1B). may damage fertility toxicant that this substance reproductive stringent regulatory human Information from authorities indicates (Presumed available. are No WHO evaluations has subsequently been amended. See been amended. has subsequently The international trade of benomyl is regulated by the Rotterdam Convention on Prior Informed Consent (see Informed Consent Prior on Convention Rotterdam the by regulated is benomyl of trade international The Common name Common [ISO] Triforine Validamycin [ISO] Vinclozolin Zineb [ISO] [ISO] Zoxamide Table 5. Technical grade active ingredients of pesticides unlikely to present acute hazard in normal use (cont.) hazard acute present to of pesticides unlikely active ingredients grade Technical 5. Table Risks Humans; ICSC = International to of Carcinogenic Guide; IARC on the Evaluation HSG = Health and Safety = IARC Monograph; Monographs Health Criteria EHC = Environmental Residues. Meeting on Pesticide FAO/WHO the Joint by JMPR = Evaluation Card; Chemical Safety 5 Table to Notes 1. 2. 3.

58 The WHO Recommended Classification of Pesticides by Hazard Table 6. Active ingredients believed to be obsolete or discontinued for use as pesticides

Ingredients discontinued have been identified from the previous edition of this classification, from the Pesticide Manual (Pesticide Manual, 1991, 1994; 1997, 2003), and in some cases from the manufacturer. It is difficult, in some cases, to be sure whether or not all commercial activity in a substance has ceased; some of these materials are known to be still in use for non-agricultural purposes. IPCS will be grateful for details of any materials in this Section, which are still in commercial use. Some active ingredients listed as obsolete in previous editions of this publication have been notified as in fact still holding active registrations in some countries. Entries for those active ingredients from previous editions have now been restored to the relevant classification tables. The common name and CAS number of each obsolete active ingredient are indicated.

Active ingredient CAS no Active ingredient CAS no Aldoxycarb 1646-88-4 Butopyronoxyl 532-34-3 Aldrin1,2 309-00-2 Buturon 3766-60-7 Allyxycarb 6392-46-7 Calcium cyanamide 156-62-7 Amidithion 919-76-6 Camphechlor1,2 8001-35-2 Aminocarb 2032-59-9 Carbamorph 31848-11-0 ANTU 86-88-4 Carbanolate 671-04-5 Aramite 140-57-8 Carbon disulfide 75-15-0 Arsenous oxide 1327-53-3 Carbophenothion 786-19-6 Athidathion 19691-80-6 Chlomethoxyfen 32861-85-1 Atraton 1610-17-9 Chloramben 133-90-4 Aziprotryne 4658-28-0 Chloranil 118-75-2 Azothoate 5834-96-8 Chloranocryl 2164-09-2 Barium carbonate 513-77-9 Chlorbenside 103-17-3 Benquinox 495-73-8 Chlorbufam 1967-16-4 Benzoximate 29104-30-1 Chlorbicyclen 2550-75-6 Benzoylprop-ethyl 22212-55-1 Chlorbormuron 13360-45-7 Benzthiazuron 1929-88-0 Chlordecone2 143-50-0 Binapacryl1 485-31-4 Chlordimeform1 6164-98-3 Bisthiosemi 39603-48-0 Chlorfenethol 80-06-8 Bromocyclen 1715-40-8 Chlorfenprop-methyl 14437-17-3 Bufencarb 8065-36-9 Chlorfenson 80-33-1 Butacarb 2655-19-8 Chlorfensulfide 2274-74-0 Butenachlor 87310-56-3 Chlormebuform 37407-77-5 Buthidazole 55511-98-3 Chlormethiuron 28217-97-2 Buthiobate 51308-54-4 Chlornitrofen 1836-77-7 Butonate 126-22-7 Chlorobenzilate1 510-15-6

Table 6. Active ingredients believed to be obsolete or discontinued for use as pesticides 59 Table 6. Active ingredients believed to be obsolete or discontinued for use as pesticides (cont.) Active ingredient CAS no Active ingredient CAS no Chloropropylate 5836-10-2 1,2-Dichloropropane 78-87-5 Chlorquinox 3495-42-9 Dichlozoline 24201-58-9 Chlorphoxim 14816-20-7 Diclobutrazol 75736-33-3 Chlorthiophos 21923-23-9 Dieldrin1,2 60-57-1 Cloethocarb 51487-69-5 Diethatyl 38727-55-8 Clofop 26129-32-8 Difenoxuron 14214-32-5 Coumachlor 81-82-3 Dimefox 115-26-4 Crimidine 535-89-7 Dimetilan 644-64-4 Credazine 14491-59-9 Dimexano 1468-37-7 Crotoxyphos 7700-17-6 Dinex 131-89-5 Crufomate 299-86-5 Dinocton 32534-96-6 Cyanofenphos 13067-93-1 Dinoseb1 88-85-7 Cyanthoate 3734-95-0 Dinoseb acetate1 2813-95-8 Cycloheximide 66-81-9 Dioxabenzophos 3811-49-2 Cycluron 2163-69-1 Dioxacarb 6988-21-2 Cyometrinil 63278-33-1 Dioxathion 78-34-2 Cypendazole 28559-00-4 Dipropetryn 4147-51-7 Cyprofuram 69581-33-5 Disul 149-26-8 Cypromid 2759-71-9 Ditalimfos 5131-24-8 Delachlor 24353-58-0 Drazoxolon 5707-69-7 Demephion-O 682-80-4 Eglinazine 6616-80-4 Demephion-S 2587-90-8 Endothion 2778-04-3 Demeton-O 298-03-3 Endrin2 72-20-8 Demeton-S 126-75-0 EPBP 3792-59-4 Demeton-S-methylsulphon 17040-19-6 Erbon 136-25-4 Desmetryn 1014-69-3 ESP (Oxydeprofos) 2674-91-1 Dialifos 10311-84-9 Etacelasil 37894-46-5 Di-allate 2303-16-4 Etaconazole 60207-93-4 Diamidafos 1754-58-1 Ethidimuron 30043-49-3 Dibromochloropropane 96-12-8 Ethiolate 2941-55-1 Dibutyl phthalate 84-74-2 Ethoate-methyl 116-01-8 Dibutyl succinate 141-03-7 Ethohexadiol 94-96-2 Dichlofenthion 97-17-6 Etrimfos 38260-54-7

60 The WHO Recommended Classification of Pesticides by Hazard Table 6. Active ingredients believed to be obsolete or discontinued for use as pesticides (cont.) Active ingredient CAS no Active ingredient CAS no EXD 502-55-6 Isazofos 42509-80-8 Fenaminosulf 140-56-7 Isobenzan 297-78-9 Fenazaflor 14255-88-0 Isobornyl thiocyano acetate 115-31-1 Fenchlorphos 299-84-3 Isocarbamid 30979-48-7 Fenitropan 65934-95-4 Isocil 314-42-1 Fenoprop (Silvex) 93-72-1 Isodrin 465-73-6 Fenson 80-38-6 Isofenphos 25311-71-1 Fensulfothion 115-90-2 Isomethiozin 57052-04-7 Fenthiaprop 95721-12-3 Isonoruron 28805-78-9 Fenuron 101-42-8 Isopropalin 33820-53-0 Fenuron-TCA 4482-55-7 Isothioate 36614-38-7 Flamprop 58667-63-3 Isoxapyrifop 87757-18-4 Fluazifop 69335-91-7 Jodfenphos 18181-70-9 Fluenetil 4301-50-2 Karbutilate 4849-32-5 Fluoromide 13577-71-4 Kelevan 4234-79-1 Fluotrimazole 31251-03-3 Kinoprene 42588-37-4 Fonofos 944-22-9 Leptophos 21609-90-5 Fosmethilan 83733-82-8 Lythidathion 2669-32-1 Fosthietan 21548-32-3 Malonoben 10537-47-0 Furconazole-cis 112839-32-4 Mebenil 7055-03-0 Furmecyclox 60568-05-0 Mecarbinzid 27386-64-7 Glyodin 556-22-9 Mecarphon 29173-31-7 Glyphosine 2439-99-8 Medinoterb acetate 2487-01-6 Griseofulvin 126-07-8 Menazon 78-57-9 Halacrinate 34462-96-9 Mephospholan 950-10-7 Haloxydine 2693-61-0 Methazole 20354-26-1 Heptachlor1,2 76-44-8 Methiuron 21540-35-2 Heptopargil 73886-28-9 Methoprotryne 841-06-5 Hexachloroacetone 116-16-5 Methoxyethylmercury 64491-92-5 silicate1 Hexaflurate 17029-22-0 Methoxyphenone 41295-28-7 Hydroxyquinoline sulfate 134-31-6 Methoxymethyl mercury 123-88-6 Ipazine 1912-25-0 chloride1 IPSP 5827-05-4 Methylmercury dicyandiamide1 502-39-6

Table 6. Active ingredients believed to be obsolete or discontinued for use as pesticides 61 Table 6. Active ingredients believed to be obsolete or discontinued for use as pesticides (cont.) Active ingredient CAS no Active ingredient CAS no Metsulfovax 21452-18-6 Propaphos 7292-16-2 Mexacarbate 315-18-4 Propyl isome 83-59-0 Mipafox 371-86-8 Prothoate 2275-18-5 Mirex2 2385-85-5 Proxan 108-25-8 Monuron 150-68-5 Pydanon 22571-07-9 Monuron-TCA 140-41-0 Pyracarbolid 24691-76-7 Morfamquat 4636-83-3 Pyridinitril 1086-02-8 Myclozolin 54864-61-8 Quinacetol sulfate 57130-91-3 Naphthalic anhydride 81-84-5 Quinonamid 27541-88-4 Nitralin 4726-14-1 Ryania 8047-13-0 Norbormide 991-42-4 Salicylanilide 87-17-2 Noruron 18530-56-8 Schradan 152-16-9 Oxapyrazon 4489-31-0 Secbumeton 26259-45-0 Oxydisulfoton 2497-07-6 Sesamex 51-14-9 Parafluron 7159-99-1 Sodium hexafluorosilicate 16893-85-9 Perfluidone 37924-13-3 Sulfoxide 120-62-7 Phenisopham 57375-63-0 Sulprofos 35400-43-2 Phenkapton 2275-14-1 SWEP 1918-18-9 Phenobenzuron 3134-12-1 2,4,5-T1 93-76-5 Phenylmercurydimethyl- 32407-99-1 TCA-ethadyl 2514-53-6 dithiocarbamate1 TDE 72-54-8 Phenylmercury nitrate1 8003-05-2 TEPP 107-49-3 Phosacetim 4104-14-7 Terbucarb 1918-11-2 Phosdiphen 36519-00-3 Tetrasul 2227-13-6 Phosfolan 947-02-4 Thicyofen 116170-30-0 Pindone 83-26-1 Thionazin 297-97-2 Piproctanyl 69309-47-3 Thiophanate 23564-06-9 Pirimiphos-ethyl 23505-41-1 Thioquinox 93-75-4 Potassium cyanate 590-28-3 Toxaphene1,2 8001-35-2 Profluralin 26399-36-0 Triamiphos 1031-47-6 Proglinazine 68228-20-6 Triapenthenol 76608-88-3 Promacyl 34264-24-9 Triarimol 26766-27-8 Promecarb 2631-37-0 Tricamba 2307-49-5

62 The WHO Recommended Classification of Pesticides by Hazard Table 6. Active ingredients believed to be obsolete or discontinued for use as pesticides (cont.) Active ingredient CAS no Active ingredient CAS no Trichlamide 70193-21-4 Trifenmorph 1420-06-0 Trichloronat 327-98-0 Trimethacarb 12407-86-2 Tridiphane 58138-08-2

1 The international trade of aldrin, binapacryl, camphechlor (toxaphene), chlordimeform, chlorobenzilate, dieldrin, dinoseb and dinoseb salts, heptachlor, mercury compounds, and 2,4,5-T is regulated by the Rotterdam Convention on Prior Informed Consent (see http://www.pic.int/), which entered into force on 24 February 2004 and has subsequently been amended. See Table 7, p. 65. 2 The use and production of aldrin, camphechlor (toxaphene), chlordecone, dieldrin, endrin, heptachlor and mirex is prohibited or severely restricted by the Stockholm Convention on persistent organic pollutants (see http://www.pops.int/), which entered into force on 17 May, 2004 and has subsequently been amended.

Table 6. Active ingredients believed to be obsolete or discontinued for use as pesticides 63 64 The WHO Recommended Classification of Pesticides by Hazard Table 7. Pesticides subject to the Rotterdam Convention1

Class Pesticide CAS number II Alachlor 15972-60-8 Ia Aldicarb 116-06-3 O Aldrin 2 309-00-2 Ib Azinphos-methyl 86-50-0 O Binapacryl 485-31-4 Ia Captafol 2425-06-1 Ib Carbofuran 1563-66-2 II Chlordane 2 57-74-9 O Chlordimeform 6164-98-3 O Chlorobenzilate 510-15-6 II DDT 2 50-29-3 FM 1,2-Dibromoethane (EDB) 106-93-4 O Dieldrin 2 60-57-1 O Dinoseb and its salts and esters 88-85-7 Ib DNOC and its salts (such as ammonium salt, potassium salt and 534-52-1; 2980-64-5; sodium salt) 5787-96-2; 2312-76-7 II Endosulfan 2 115-29-7 FM Ethylene dichloride 107-06-2 FM Ethylene oxide 75-21-8 Ib Fluoroacetamide 640-19-7 II HCH (mixed isomers) 608-73-1 O Heptachlor 2 76-44-8 Ia Hexachlorobenzene 2 118-74-1 II Lindane 2 58-89-9 Mercury compounds, including inorganic mercury compounds, alkyl mercury compounds and alkyloxyalkyl and aryl mercury compounds Ib Pentachlorophenol and its salts and esters 2 87-86-5 Ia Phorate 298-02-2 O 2,4,5-T and its salts and esters 93-76-5 O Toxaphene (Camphechlor) 2 8001-35-2 II Trichlorfon 52-68-6 Dustable powder formulations containing a combination of 17804-35-2; benomyl at or above 7%, carbofuran at above 10%, thiram at or 1563-66-2; above 15% (Severely Hazardous Pesticide Formulation) 137-26-8 Ib Methamidophos (all formulations) 10265-92-6

Table 7. Pesticides subject to the Rotterdam Convention 65 Table 7. Pesticides subject to the Rotterdam Convention1 (cont.)

Class Pesticide CAS number Ia Methyl-parathion (emulsifiable concentrates (EC) at or above 298-00-0 19.5% active ingredient and dusts at or above 1.5% active ingredient (Severely Hazardous Pesticide Formulation) Ib Monocrotophos (all formulations) 6923-22-4 Ia Parathion (all formulations) 56-38-2 Ia Phosphamidon (soluble liquid formulations of the substance that 13171-21-6 [mixture, exceed 1000 g active ingredient/L) (E) & (Z) isomers] (Severely Hazardous Pesticide Formulation) 23783-98-4 [(Z)-isomer] 297-99-4 [(E)-isomer] Tributyltin compounds

1 According to the Rotterdam Convention, export of a chemical can only take place with the prior informed consent of the importing Party. The Prior Informed Consent (PIC) procedure is a means for formally obtaining and disseminating the decisions of importing countries as to whether they wish to receive future shipments of a certain chemical and for ensuring compliance to these decisions by exporting countries. The aim is to promote a shared responsibility between exporting and importing countries in protecting human health and the environment from the harmful effects of such chemicals (further information can be found at: http://www.pic.int/). The Rotterdam Convention (which entered into force on 24 February 2004 and has subsequently been amended) built on the voluntary PIC procedure which was initiated by UNEP and FAO in 1989. 2 The use and production of aldrin, chlordane, DDT, dieldrin, technical endosulfan and its related isomers, heptachlor, hexachlorobenzene, lindane, pentachlorophenol and its salts and esters and toxaphene (camphechlor) is prohibited or severely restricted by the Stockholm Convention on persistent organic pollutants, which entered into force on 17 May, 2004 and has subsequently been amended. See http://www.pops.int/

66 The WHO Recommended Classification of Pesticides by Hazard Table 8. Gaseous or volatile fumigants not classified under the WHO Recommended Classification of Pesticides by Hazard

The Classification does not set out any criteria for air concentrations on which classification could be based. In response to requests for more information on fumigants, classifications for inhalation toxicity from other sources are presented. Most of these compounds are of high hazard and recommended exposure limits for occupational exposure have been adopted by national authorities in many countries.

CAS Classification for Pesticide number inhalation toxicity Remarks Acrylonitrile 107-13-1 Toxic if inhaled; See note 1 ICSC 92 Aluminium phosphide 20859-73-8 See note 2 EHC 73; HSG 28; ICSC 472; JMPR 1967; High case fatality reported Chloropicrin 76-06-2 Fatal if inhaled ICSC 750 ; JMPR 1965b 1,2-Dibromoethane 106-93-4 Toxic if inhaled; see note 3 EHC 177; IARC 71 (Group 2A); (ethylene dibromide, EDB)1 ICSC 45 1,3-Dichloropropene 542-75-6 Toxic if inhaled; see note 3 EHC 146; HSG 76; IARC 71 (Group 2B); ICSC 995 Ethylene dichloride1 107-06-2 Toxic if inhaled; see note 4 EHC 62, 176; HSG 55; IARC 71 (Group 2B); ICSC 250 Ethylene oxide1 75-21-8 Toxic if inhaled; see note 5 EHC 55; HSG 16; JMPR 1969; IARC 100F (Group 1); ICSC 155 Formaldehyde 50-00-0 Fatal if inhaled EHC 89; HSG 57; IARC 100F (Group 1); ICSC 275 Hydrogen cyanide 74-90-8 Fatal if inhaled; see note 6 ICSC 492; JMPR 1965b Magnesium phosphide 12057-74-8 See note 7 EHC 73; HSG 28; ICSC 744 Methyl bromide2 74-83-9 Toxic if inhaled EHC 166; HSG 86; IARC 71 (Group 3); ICSC 109; JMPR 1967 Phosphine 7803-51-2 Fatal if inhaled EHC 73; HSG 28; ICSC 694; JMPR 1967 Sulfuryl fluoride 2699-79-8 Toxic if inhaled ICSC 1402; JMPR 2005

EHC = Environmental Health Criteria Monograph; HSG = Health and Safety Guide; IARC = IARC Monographs on the Evaluation of Carcinogenic Risks to Humans; ICSC = International Chemical Safety Card; JMPR = Evaluation by the Joint FAO/WHO Meeting on Pesticide Residues. 1 The international trade of 1,2-dibromoethane (ethylene dibromide or EDB), ethylene dichloride and ethylene oxide is regulated by the Rotterdam Convention on Prior Informed Consent (see http://www.pic.int/), which entered into force on 24 February 2004 and has subsequently been amended. See Table 7, p. 65. 2 The use and production of methyl bromide is prohibited or severely restricted by the Montreal Protocol on Substances that Deplete the Ozone Layer (see https://www.informea.org/en/treaties/montreal-protocol), which entered into force on 1 January 1989. Notes to Table 8 1. Acrylonitrile is also toxic if swallowed or in contact with skin. 2. Aluminium phosphide is used in the form of solid pellets, which release phosphine gas following exposure to moisture (including exposure to air or following ingestion). Phosphine has a separate entry in Table 8. Solid aluminium phosphide is classified as fatal if swallowed. A high case fatality has been reported in poisoning cases with aluminium phosphide (Dawson et al, 2010). 3. In liquid form this substance is also classified as toxic if swallowed or in contact with skin.

Table 8. Gaseous or volatile fumigants 67 Table 8. Gaseous or volatile fumigants not classified under the WHO Recommended Classification of Pesticides by Hazard (cont.)

4. In liquid form this substance is also classified as harmful if swallowed and may be harmful in contact with skin. 5. IARC has determined ethylene oxide to be carcinogenic to humans (Group 1). 6. In liquid form this substance is also fatal if swallowed or in contact with skin. 7. Magnesium phosphide is used in the form of solid pellets, which release phosphine gas following exposure to moisture (including exposure to air or following ingestion). Phosphine has a separate entry in Table 8. Solid magnesium phosphide is classified as fatal if swallowed.

68 The WHO Recommended Classification of Pesticides by Hazard ANNEX: HOW TO FIND THE HAZARD CLASS OF A FORMULATION

The following tables A and B can be used to find the hazard class of a formulation. These should be used only if toxicity data is not available on the formulation itself; see the note at the top of page 8.

The tables should be used as follows:

Step 1: What is the approved name of the active ingredient in the pesticide? Use the index to find the entry intables 1–5 of the Guidelines.

Step 2: From the entry in the Guidelines, what is the route of application used for the classification? If the route is O (oral), use table A of this Annex. The same table is used for solids and liquids. If the route is D (dermal), use table B of this Annex. The same table is used for solids and liquids.

Step 3: From the entry in the Guidelines, what is the LD50 of the active ingredient? Using the table A or B, selected in Step 2, find the column along the top line which most

nearly includes the LD50 figure.

Step 4: What is the concentration % of the active ingredient in the formulation? Using the same table A or B, find the figure in the left hand column which most nearly includes this percentage figure.

Step 5: Find the square where the column selected in Step 3 crosses the line selected in Step 4.

The number in this square is the approximate LD50 of the formulation.

Step 6: The hazard classes are shown by blocks of squares. The hazard class of the formulation is that of the block in which lies the square selected in Step 5.

These tables can also be used to find the hazard class of mixtures. First see pages 8 and 9, para. 4 of the

Guidelines and select the method to be used to arrive at the LD50 of the mixture. For method (b), use the above method from Step 1, using the name of the more or most toxic ingredient. For method (c), pass to Step 4 using the total percentages of all active ingredients in the mixture.

ANNEX: HOW TO FIND THE HAZARD CLASS OF A FORMULATION 69 5000 5000 4500 4500 4737 5000 4000 4000 4211 4444 4706 5000 Y 3500 3500 3684 EL 3889 4118 4375 4667 5000 IK II I 5000 3000 3000 3158 3333 3529 3750 UNL 4000 4286 4615 T s EN as 500 500 632 ES 4167 Cl 4545 5000 2778 2941 3125 3333 3571 3846 PR RD 00 02 00 02 10 52 353 O 3333 3636 4000 4444 5000 2222 2500 2667 2857 T 3077 ZA HA 50 02 50 02 57 92 28 6 76 52 00 0 2500 2727 3000 3333 3750 1667 1875 2000 2143 2308 E E CUT 00 01 00 01 05 31 85 74 17 61 33 35 000 00 0 US 1667 A 1818 2000 2222 2500 1111 1250 1333 1429 1538

AL 90 01 90 01 94 71 57 12 05 91 00 03 60 04 50 05 1500 1636 1800 2000 2250 1000 1125 1200 1286 1385 RM NO 00 00 42 89

333 455 600 778 000 28 62 66 73 94 11 20 03 00 04 143 231 IN 1000 1067 24 75 33 70 08 70 08 73 78 77 88 116 71 127 31 140 01 155 61 175 02 200 02 233 32 280 03 350 04 100 01 466 7 107 71 00 00 32 67 70 68 75 08 80 09 857 923 1000 1091 1200 1333 1500 1714 2000 2400 3000 4000 33 09 88 25 67 14 69 000 50 06 000 50 06 111 52 66 55 66 429 000 500 333 1250 1667 00 00 21 44 00 05 66 78 72 79 80 01 88 91 14 31 47 15 50 06 60 02 53 36 00 02 57 17 66 73 61 57 1000 1333 83 36 00 78 75 12 38 67 00 38 35 04 35 04 36 84 00 01 38 94 350 04 1167 140 01 175 02 233 32 00 00 16 33 000 50 05 54 56 60 07 66 77 75 08 85 71 35 34 37 54 40 04 500 42 95 000 46 25 1000 1200 50 03 00 0 417 455 25 03 500 25 03 556 26 33 625 27 83 714 294 833 313 25 01 333 66 72 357 385 1000 333 364 200 400 200 444 211 500 222 571 235 667 250 800 267 286 308 200 02 400 05 100 01 133 31 800 300 600 327 180 360 180 400 189 450 200 514 212 600 225 720 240 900 257 200 277 267 291 160 320 160 356 168 400 178 457 188 533 200 640 213 800 229 246 160 01 320 03 106 71 33 55 40 80 40 11 47 50 56 00 65 67 75 60 87 00 00 15 933 1400 2800 4667 00 20 02 21 82 12 01 24 02 12 01 26 73 12 61 30 03 13 31 34 14 11 40 04 15 01 48 05 16 01 60 07 17 12 18 52 1200 2400 4000 167 182 100 200 100 222 105 250 111 286 118 333 125 400 133 500 143 66 78 154 1000 2000 3333 0 0 4 9 4 00 33 133 145 160 178 200 229 267 100 320 107 400 114 123 II 1600 2667 s 08 08 38 78 19 5 0 6 2 as 60 08 100 109 120 133 150 171 200 240 300 40 05 Cl 1200 2000 values and classification of formulations when the route is ORA L 3 1 06 06 36 66 97 37 78 18 79 00 11 50 25 43 67 00 50 33 100 1000 1667 5000 58 29 55 55 75 05 35 66 06 47 97 90 45 05 900 10 01 11 31 12 91 15 01 18 02 22 52 30 03 1500 4500 77 38 04 04 24 45 75 05 36 76 26 80 89 400 800 100 114 133 160 200 267 1333 4000 86 47 54 54 74 94 14 45 75 05 46 50 00 70 78 88 40 33 Table A. LD Table 100 117 175 1167 3500 05 56 03 03 23 33 54 84 04 35 65 60 67 75 86 00 50 30 03 60 07 12 01 20 02 1000 3000 25 55 53 53 63 83 93 31 13 34 64 84 50 00 50 56 63 71 00 67 833 12 51 2500 5000 of the active ingredient 02 34 64 02 02 12 22 42 78 53 01 73 93 13 50 67 40 44 50 57 00 40 05 20 13 31 2000 4000 of the active ingredient the active of 53 73 52 52 62 72 82 06 92 08 02 51 12 33 00 30 33 38 43 00 50 50 50 06 Ib 1500 5000 3000 s 72 82 01 01 11 11 21 35 31 06 32 07 42 71 52 33 20 22 25 29 as 20 03 000 10 01 Cl 3333 2000

values and classification of formulations when the route is ORALroute when the formulations of and classification values 81 73 04 55 36 00 10 11 13 14 50 50 16 73 50 01 5000 1667 1000 01 01 22 52 03 First row = Oral LD First column = Percent concentration of the active ingredient in formulation 30 100 300 600 Ia 3000 1000 06 25 91 13 51 3 26 13 51 27 13 51 38 13 61 39 14 61 31 14 61 41 14 71 51 14 71 72 25 81 25 ss 00 33 00 10 a Cl 1000 2000 52 33 33 11 52 55 50 45 95 40 90 35 85 30 80 25 75 20 70 15 10 65 60 0.1 0. 0. 100 0.05 Table A. LD Table = Oral LD row First in the formulation ingredient the active of concentration = Percent column First

70 The WHO Recommended Classification of Pesticides by Hazard 00 0 00 0 Y 50 05 50 05 73 7 5000 EL IK 00 04 00 04 21 14 00 0 4444 UNL 4706 T EN 50 04 50 04 68 44 37 55 66 7 ES 3889 4118 5000 PR

RD 00 03 00 03 15 83 75 04 00 04 III 4615 5000 3333 3529 TO 4286 ZA s as HA 50 03 50 03 63 23 12 53 33 34 Cl 3846 4167 4545 5000 2778 2941 E 3571 UT E 00 02 00 02 10 52 50 03 66 73 US 3077 AC 3333 3636 4000 4444 2222 5000 2353 2857

AL 50 02 50 02 57 92 87 52 00 02 2308 2500 2727 3000 3333 1667 3750 1765 4286 5000 2143 RM NO

00 01 00 01 05 31 25 01 33 32 1538 1667 IN 1818 2000 2222 1111 2500 1176 2857 3333 4000 1429 5000 90 01 90 01 94 71 12 51 20 01 1385 1500 1636 1800 2000 1000 2250 1059 2571 3000 3600 1286 4500 00 00 42 89 41 00 01 06 71 1231 1333 1455 1600 1778 2000 2286 2667 3200 1143 4000 70 08 70 08 73 78 77 88 82 49 87 51 93 31 4667 1077 1167 1273 1400 1556 1750 2000 2333 2800 1000 3500 923 600 600 632 667 706 750 800 857 4000 1000 1091 1200 1333 1500 1714 2000 2400 3000 69 00 33 00 09 26 56 88 25 67 14 000 250 667 500 5000 1111 1429 2000 3333 69 27 45 05 75 08 45 05 81 89 47 45 90 01 50 05 12 51 52 95 56 36 50 01 60 06 64 37 25 02 4500 1000 1286 1800 3000 15 00 67 00 27 21 00 44 89 71 00 33 71 00 01 33 31 00 02 4000 1143 1600 2667 53 86 35 04 58 36 35 04 63 67 36 84 70 08 38 94 77 88 87 51 41 24 43 85 16 71 46 75 50 05 75 02 3500 1000 1400 2333 62 00 00 00 45 16 00 33 67 50 53 57 75 00 29 00 01 50 01 II 3000 1200 2000 s as 38 54 25 03 41 75 25 03 45 55 26 33 50 06 27 83 55 66 62 57 29 43 71 48 31 33 83 31 33 34 35 74 25 01 Cl 2500 5000 1000 1667 08 00 33 00 64 11 00 22 44 00 35 71 50 67 67 00 86 00 01 2000 4000 1333 27 73 18 02 30 03 18 02 32 73 18 92 36 04 20 02 40 04 45 05 21 22 51 45 22 52 60 06 24 02 72 08 25 72 90 01 1800 3600 1200 246 160 267 160 291 168 320 178 356 400 188 457 200 533 213 640 229 800 1600 3200 1067 215 140 233 140 255 147 280 311 156 350 165 400 175 467 187 560 200 700 933 1400 2800 466 7 20 00 18 26 40 67 50 60 185 200 120 133 300 141 343 400 480 171 600 800 2400 4000 54 00 11 50 18 86 33 00 43 00 67 10 01 00 01 16 72 18 22 10 51 20 02 22 12 51 13 31 2000 3333 values and classification of formulations when the route is DER MAL 01 50 90 50 64 80 95 00 13 20 90 01 10 01 22 52 10 61 25 72 30 03 36 04 12 91 45 05 13 81 60 06 1800 3000 09 00 80 84 89 00 94 29 67 20 14 00 23 33 13 31 14 51 16 01 17 82 10 01 10 71 1600 2667 08 70 17 27 40 74 56 78 82 88 93 70 08 17 52 20 02 23 32 28 03 10 01 35 04 10 81 46 75 Ib 1400 2333 s Table B. LD Table 07 00 60 63 67 50 71 71 75 00 80 40 86 00 92 00 as 10 01 000 10 91 12 01 13 31 Cl 1200 06 50 83 91 00 53 11 56 59 63 67 71 77 of the active ingredient 50 06 66 72 00 0 12 51 14 31 16 72 20 02 25 03 33 34 1000 50 05 01 91 40 67 73 42 44 47 50 53 57 62 400 800 100 114 133 160 200 267 of the active ingredient the active of 133 31 400 05 50 04 08 78 5 6 30 50 55 32 33 35 38 40 43 46 300 600 100 120 150 200 1000 3000 03 06 46 07 78 7 0 00 20 33 00 67 36 21 22 24 25 27 29 00 31 33 000 4000 02 04 24 55 95 36 08 01 71

values and classification of formulations when the route is DERMAL route when the formulations of and classification values 10 17 18 11 11 12 13 13 14 15 10 02 20 04 33 36 00 02 50 2000 3333 02 12 32 42 73 04 55 36 First row = Dermal LD First column = Percent concentration of the active ingredient in formulation 50 00 67 50 01 Ia 1000 1667 5000 15 28 01 31 29 21 15 21 16 31 16 31 16 31 17 42 17 52 28 73 ss 10 00 00 33 a 000 Cl 52 33 11 52 33 11 10 60 55 50 95 45 90 40 85 35 80 30 75 25 70 20 65 15 0. 0. 0. 10 01 51 Table B. LD B. Table = Dermal LD row First in the formulation ingredient the active of concentration = Percent column First

ANNEX: HOW TO FIND THE HAZARD CLASS OF A FORMULATION 71 CAS # TOC

Pesticide active ingredients, which occur in Tables 1–8, in CAS no. order

For each active ingredient, the WHO Class (Ia, Ib, II, III or U) and page number(s) are given. The active ingredients without a WHO Class are shown as O (obsolete) or FM (fumigant).

CAS# CLASS PAGE CAS# CLASS PAGE CAS# CLASS PAGE 50-00-0 FM 67 75-56-9 II 37 90-43-7 III 46 50-29-3 II 30, 65 75-60-5 II 31 91-20-3 II 35 50-31-7 II 38 75-99-0 U 51 92-52-4 III 41 50-65-7 U 54 76-03-9 II 38 93-71-0 II 27 51-03-6 U 55 76-06-2 FM 67 93-72-1 O 61 51-14-9 O 62 76-44-8 O 61, 65 93-75-4 O 62 52-51-7 II 28 76-87-9 II 32 93-76-5 O 62, 65 52-68-6 II 39, 65 77-06-5 U 53 94-74-6 II 34 52-85-7 Ib 24 78-34-2 O 60 94-75-7 II 30 54-11-5 Ib 25 78-57-9 O 61 94-81-5 II 34 55-38-9 II 32 78-87-5 O 60 94-82-6 II 30 56-35-9 II 28, 66 79-11-8 II 28 94-96-2 O 60 56-38-2 Ia 22, 66 80-06-8 O 59 95-06-7 II 38 56-72-4 Ib 23 80-33-1 O 59 96-12-8 O 60 57-24-9 Ib 25 80-38-6 O 61 96-24-2 Ib 23 57-74-9 II 28, 65 81-81-2 Ib 25 97-17-6 O 60 58-89-9 II 33, 65 81-82-3 O 60 97-23-4 II 30 60-51-5 II 31 81-84-5 O 62 99-30-9 III 42 60-57-1 O 60, 65 82-66-6 Ia 21 101-05-3 III 41 61-82-5 U 49 82-68-8 U 56 101-21-3 U 50 62-38-4 Ia 22 83-26-1 O 62 101-27-9 II 27 62-73-7 Ib 24 83-59-0 O 62 101-42-8 O 61 62-74-8 Ia 22 83-79-4 II 37 103-17-3 O 59 63-25-2 II 28 84-65-1 U 49 106-46-7 II 30 66-81-9 O 60 84-74-2 O 60 106-93-4 FM 65, 67 72-20-8 O 60 85-34-7 II 28 107-02-8 Ib 23 72-43-5 U 54 86-50-0 Ib 23, 65 107-06-2 FM 65, 67 72-54-8 O 62 86-86-2 U 54 107-13-1 FM 67 74-83-9 FM 67 86-87-3 III 45 107-18-6 Ib 23 74-88-4 II 35 86-88-4 O 59 107-49-3 O 62 74-90-8 FM 67 87-17-2 O 62 108-25-8 O 62 75-15-0 O 59 87-86-5 Ib 25, 65 108-62-3 II 34 75-21-8 FM 65, 67 88-85-7 O 60, 65 112-12-9 III 47

72 The WHO Recommended Classification of Pesticides by Hazard CAS# CLASS PAGE CAS# CLASS PAGE CAS# CLASS PAGE 113-48-4 III 45 139-40-2 U 56 533-74-4 II 30 114-26-1 II 37 140-41-0 O 62 534-52-1 Ib 24, 65 115-26-4 O 60 140-56-7 O 61 535-89-7 O 60 115-29-7 II 31, 65 140-57-8 O 59 542-75-6 FM 67 115-31-1 O 61 141-03-7 O 60 555-37-3 U 54 115-32-2 II 30 141-66-2 Ib 24 556-22-9 O 61 115-78-6 II 29 142-59-6 II 35 556-61-6 II 35 115-90-2 O 61 143-33-9 Ib 25 563-12-2 II 31 116-01-8 O 60 143-50-0 O 59 584-79-2 II 27 116-06-3 Ia 21, 65 148-79-8 III 47 590-28-3 O 62 116-16-5 O 61 149-26-8 O 60 592-01-8 Ia 21 116-29-0 U 57 150-68-5 O 62 608-73-1 II 33, 65 117-18-0 U 57 152-16-9 O 62 624-92-0 II 31 118-74-1 Ia 21, 65 156-62-7 O 59 640-15-3 Ib 25 118-75-2 O 59 297-78-9 O 61 640-19-7 Ib 24, 65 119-12-0 II 37 297-97-2 O 62 644-64-4 O 60 120-23-0 II 35 297-99-4 1a 22, 66 650-51-1 III 47 120-36-5 II 30 298-00-0 Ia 22, 66 671-04-5 O 59 120-62-7 O 62 298-02-2 Ia 22, 65 682-80-4 O 60 121-75-5 III 45 298-03-3 O 60 709-98-8 II 36 122-14-5 II 31 298-04-4 Ia 21 731-27-1 U 57 122-34-9 U 56 299-84-3 O 61 732-11-6 II 36 122-42-9 U 56 299-86-5 O 60 741-58-2 II 27 122-88-3 II 29 300-76-5 II 35 756-09-2 U 52 123-33-1 U 54 301-12-2 Ib 25 759-94-4 II 31 123-88-6 O 61 309-00-2 O 59, 65 786-19-6 O 59 124-58-3 II 35 314-40-9 U 50 834-12-8 II 27 126-07-8 O 61 314-42-1 O 61 841-06-5 O 61 126-22-7 O 59 315-18-4 O 62 886-50-0 III 47 126-75-0 O 60 327-98-0 O 63 900-95-8 II 32 129-67-9 II 31 330-54-1 III 43 919-76-6 O 59 131-11-3 U 51 330-55-2 III 45 919-86-8 Ib 24 131-72-6 III 45 333-41-5 II 30 944-22-9 O 61 131-89-5 O 60 371-86-8 O 62 947-02-4 O 62 132-66-1 U 54 465-73-6 O 61 950-10-7 O 61 133-06-2 U 50 467-69-6 U 52 950-37-8 Ib 24 133-07-3 U 53 470-90-6 Ib 23 957-51-7 II 31 133-90-4 O 59 485-31-4 O 59, 65 973-21-7 II 31 134-31-6 O 61 495-73-8 O 59 991-42-4 O 62 134-62-3 III 42 502-39-6 O 61 999-81-5 II 28 136-25-4 O 60 502-55-6 O 61 1014-69-3 O 60 137-26-8 II 38, 65 510-15-6 O 59, 65 1014-70-6 II 37 137-30-4 II 39 513-77-9 O 59 1031-47-6 O 62 137-42-8 II 35 532-34-3 O 59 1071-83-6 III 44

Pesticide active ingredients, which occur in Tables 1–8, in CAS no. order 73 CAS# CLASS PAGE CAS# CLASS PAGE CAS# CLASS PAGE 1085-98-9 U 51 1929-82-4 II 35 2597-03-7 II 36 1086-02-8 O 62 1929-88-0 O 59 2631-37-0 O 62 1113-02-6 Ib 25 1967-16-4 O 59 2631-40-5 II 34 1114-71-2 II 36 1982-47-4 III 42 2636-26-2 II 29 1129-41-5 II 35 1982-49-6 U 56 2642-71-9 Ib 23 1134-23-2 III 42 2008-41-5 III 41 2655-14-3 II 39 1194-65-6 III 42 2032-59-9 O 59 2655-19-8 O 59 1303-96-4 III 41 2032-65-7 Ib 25 2669-32-1 O 61 1314-84-7 Ib 25 2079-00-7 Ib 23 2674-91-1 O 60 1317-39-1 II 29 2104-64-5 Ia 21 2675-77-6 U 50 1327-53-3 O 59 2104-96-3 II 28 2693-61-0 O 61 1332-40-7 II 29 2163-69-1 O 60 2699-79-8 FM 67 1420-06-0 O 63 2164-08-1 U 54 2759-71-9 O 60 1420-07-1 Ib 24 2164-09-2 O 59 2764-72-9 II 31 1468-37-7 O 60 2164-17-2 U 52 2778-04-3 O 60 1563-66-2 Ib 23, 65 2212-67-1 II 35 2797-51-5 II 37 1582-09-8 U 57 2227-13-6 O 62 2813-95-8 O 60, 65 1593-77-7 III 43 2227-17-0 III 42 2921-88-2 II 29 1596-84-5 U 51 2274-74-0 O 59 2941-55-1 O 60 1610-17-9 O 59 2275-14-1 O 62 2980-64-5 1b 24, 65 1610-18-0 III 46 2275-18-5 O 62 3060-89-7 III 45 1646-88-4 O 59 2275-23-2 Ib 25 3134-12-1 O 62 1689-83-4 II 34 2303-16-4 O 60 3337-71-1 III 41 1689-84-5 II 28 2303-17-5 III 47 3347-22-6 II 31 1698-60-8 III 41 2307-49-5 O 62 3383-96-8 III 47 1702-17-6 III 42 2307-68-8 U 55 3495-42-9 O 60 1715-40-8 O 59 2310-17-0 II 36 3547-33-9 U 53 1746-81-2 III 45 2312-35-8 III 46 3689-24-5 Ia 22 1754-58-1 O 60 2312-76-7 Ib 24, 65 3691-35-8 Ia 21 1836-75-5 III 45 2385-85-5 O 62 3734-95-0 O 60 1836-77-7 O 59 2425-06-1 Ia 21, 65 3737-22-2 U 51 1861-32-1 III 42 2425-10-7 II 39 3740-92-9 U 52 1861-40-1 U 49 2439-01-2 III 41 3766-60-7 O 59 1897-45-6 U 50 2439-10-3 II 31 3766-81-2 II 32 1912-24-9 III 41 2439-99-8 O 61 3792-59-4 O 60 1912-25-0 O 61 2464-37-1 U 50 3811-49-2 O 60 1912-26-1 III 47 2487-01-6 O 61 3813-05-6 III 41 1918-00-9 II 30 2497-07-6 O 62 3861-47-0 II 34 1918-02-1 U 55 2514-53-6 O 62 3878-19-1 II 33 1918-11-2 O 62 2540-82-1 II 33 4104-14-7 O 62 1918-13-4 II 29 2550-75-6 O 59 4147-51-7 O 60 1918-16-7 II 36 2587-90-8 O 60 4151-50-2 II 38 1918-18-9 O 62 2593-15-9 III 43 4234-79-1 O 61 1929-77-7 II 39 2595-54-2 Ib 24 4301-50-2 O 61

74 The WHO Recommended Classification of Pesticides by Hazard CAS# CLASS PAGE CAS# CLASS PAGE CAS# CLASS PAGE 4482-55-7 O 61 7784-46-5 Ib 25 14437-17-3 O 59 4489-31-0 O 62 7786-34-7 Ia 21 14484-64-1 U 52 4636-83-3 O 62 7803-51-2 FM 67 14491-59-9 O 60 4658-28-0 O 59 8001-35-2 O 59, 62, 65 14750-35-4 U 50 4685-14-7 II 36 8003-05-2 O 62 14816-18-3 II 36 4726-14-1 O 62 8003-34-7 II 37 14816-20-7 O 60 4824-78-6 Ib 23 8018-01-7 U 54 15096-52-3 U 50 4849-32-5 O 61 8047-13-0 O 62 15263-53-3 II 28 5131-24-8 O 60 8065-36-9 O 59 15299-99-7 U 54 5221-53-4 III 43 9006-42-2 U 54 15302-91-7 II 34 5234-68-4 III 41 10004-44-1 III 44 15310-01-7 U 49 5259-88-1 III 46 10112-91-1 II 34, 65 15457-05-3 U 52 5598-13-0 III 42 10265-92-6 Ib 24, 65 15545-48-9 U 50 5707-69-7 O 60 10311-84-9 O 60 15845-66-2 U 53 5787-96-2 1b 24, 65 10380-28-6 U 55 15879-93-3 II 28 5827-05-4 O 61 10453-86-8 III 46 15972-60-8 II 27, 65 5834-96-8 O 59 10537-47-0 O 61 16118-49-3 U 50 5836-10-2 O 60 10552-74-6 U 55 16484-77-8 II 34 5836-29-3 Ib 23 10605-21-7 U 50 16672-87-0 III 43 5902-51-2 U 57 12002-03-8 Ib 25 16752-77-5 Ib 25 5915-41-3 III 47 12057-74-8 FM 67 16893-85-9 O 62 6164-98-3 O 59, 65 12071-83-9 U 56 17029-22-0 O 61 6392-46-7 O 59 12122-67-7 U 58 17040-19-6 O 60 6616-80-4 O 60 12407-86-2 O 63 17109-49-8 Ib 24 6923-22-4 Ib 25, 66 12427-38-2 U 54 17606-31-4 II 27 6988-21-2 O 60 12771-68-5 III 41 17804-35-2 U 49, 65 7055-03-0 O 61 13067-93-1 O 60 18181-70-9 O 61 7085-19-0 II 34 13071-79-9 Ia 22 18181-80-1 U 50 7159-99-1 O 62 13121-70-5 II 29 18467-77-1 U 51 7287-19-6 III 46 13171-21-6 Ia 22, 66 18530-56-8 O 62 7287-36-7 III 45 13181-17-4 II 28 18691-97-9 III 45 7292-16-2 O 62 13194-48-4 Ia 21 18854-01-8 Ib 24 7446-18-6 Ib 25 13356-08-6 III 43 19044-88-3 U 55 7487-94-7 Ia 21, 65 13360-45-7 O 59 19408-46-9 U 53 7681-49-4 II 37 13457-18-6 II 37 19666-30-9 U 55 7681-93-8 III 46 13516-27-3 II 33 19691-80-6 O 59 7696-12-0 U 57 13577-71-4 O 61 19937-59-8 III 45 7700-17-6 O 60 13593-03-8 II 37 20354-26-1 O 61 7704-34-9 III 47 13598-36-2 U 55 20427-59-2 II 29 7758-98-7 II 29 13684-56-5 U 51 20859-73-8 FM 67 7773-06-0 III 41 13684-63-4 U 55 21087-64-9 II 35 7775-09-9 II 37 13952-84-6 II 28 21452-18-6 O 62 7778-44-1 Ib 23 14214-32-5 O 60 21540-35-2 O 61 7784-40-9 Ib 24 14255-88-0 O 61 21548-32-3 O 61

Pesticide active ingredients, which occur in Tables 1–8, in CAS no. order 75 CAS# CLASS PAGE CAS# CLASS PAGE CAS# CLASS PAGE 21609-90-5 O 61 27314-13-2 II 35 35367-38-5 III 42 21725-46-2 II 29 27355-22-2 U 55 35400-43-2 O 62 21908-53-2 Ib 24, 65 27386-64-7 O 61 35554-44-0 II 33 21923-23-9 O 60 27541-88-4 O 62 35575-96-3 II 27 22212-55-1 O 59 27605-76-1 III 46 36335-67-8 II 28 22224-92-6 Ib 24 28217-97-2 O 59 36519-00-3 O 62 22248-79-9 III 47 28249-77-6 II 38 36614-38-7 O 61 22259-30-9 Ib 24 28434-01-7 U 49 36734-19-7 III 44 22571-07-9 O 62 28559-00-4 O 60 36756-79-3 U 57 22781-23-3 II 27 28772-56-7 Ia 21 37248-47-8 U 58 22936-75-0 III 43 28805-78-9 O 61 37407-77-5 O 59 23031-36-9 II 36 29091-05-2 III 43 37764-25-3 III 42 23103-98-2 II 36 29091-21-2 U 55 37893-02-0 III 44 23135-22-0 Ia 21 29104-30-1 O 59 37894-46-5 O 60 23184-66-9 III 41 29173-31-7 O 61 37924-13-3 O 62 23505-41-1 O 62 29232-93-7 II 36 38260-54-7 O 60 23560-59-0 Ib 24 29973-13-5 Ib 24 38727-55-8 O 60 23564-05-8 U 57 30043-49-3 O 60 39148-24-8 U 53 23564-06-9 O 62 30560-19-1 II 27 39196-18-4 Ib 25 23783-98-4 Ia 22, 66 30979-48-7 O 61 39300-45-3 II 31 23947-60-6 U 51 31218-83-4 Ib 25 39515-40-7 II 29 23950-58-5 U 56 31251-03-3 O 61 39515-41-8 II 32 24017-47-8 Ib 25 31848-11-0 O 59 39603-48-0 O 59 24151-93-7 II 36 31895-22-4 II 38 40487-42-1 II 36 24201-58-9 O 60 32407-99-1 O 62 40596-69-8 U 54 24353-58-0 O 60 32534-96-6 O 60 40843-25-2 II 30 24579-73-5 U 56 32791-87-0 U 50 41083-11-8 II 27 24691-76-7 O 62 32809-16-8 U 55 41096-46-2 U 53 24691-80-3 U 52 32861-85-1 O 59 41198-08-7 II 36 24934-91-6 Ia 21 33089-61-1 II 27 41295-28-7 O 61 25057-89-0 II 27 33245-39-5 II 32 41394-05-2 II 34 25311-71-1 O 61 33629-47-9 II 28 41483-43-6 III 41 25319-90-8 II 34 33693-04-8 II 38 41814-78-2 II 39 25366-23-8 II 38 33820-53-0 O 61 42509-80-8 O 61 25954-13-6 III 44 34014-18-1 II 38 42576-02-3 U 49 26002-80-2 U 55 34123-59-6 II 34 42588-37-4 O 61 26087-47-8 II 34 34205-21-5 III 43 42609-52-9 U 51 26129-32-8 O 60 34256-82-1 III 41 42609-73-4 III 45 26225-79-6 U 51 34264-24-9 O 62 42874-03-3 U 55 26259-45-0 O 62 34462-96-9 O 61 43121-43-3 II 38 26399-36-0 O 62 34643-46-4 II 37 43222-48-6 II 30 26530-20-1 II 36 34681-10-2 Ib 23 50471-44-8 U 58 26644-46-2 U 58 34681-23-7 Ib 23 50512-35-1 II 34 26766-27-8 O 62 35256-85-0 U 57 50563-36-5 II 30

76 The WHO Recommended Classification of Pesticides by Hazard CAS# CLASS PAGE CAS# CLASS PAGE CAS# CLASS PAGE 50594-66-6 II 27 59669-26-0 II 38 69335-91-7 O 61 51218-45-2 III 45 59756-60-4 U 53 69377-81-7 U 53 51218-49-6 U 55 60168-88-9 III 43 69409-94-5 II 33 51235-04-2 II 33 60207-31-0 II 27 69581-33-5 O 60 51308-54-4 O 59 60207-90-1 II 36 69806-34-4 II 33 51487-69-5 O 60 60207-93-4 O 60 70124-77-5 Ib 24 51630-58-1 II 32 60568-05-0 O 61 70193-21-4 O 63 51707-55-2 III 47 61213-25-0 III 44 71048-99-2 II 27 52304-36-6 U 51 61432-55-1 II 30 71283-80-2 III 43 52315-07-8 II 29 62610-77-9 II 35 71422-67-8 U 50 52645-53-1 II 36 62850-32-2 II 32 71561-11-0 II 37 52888-80-9 II 37 62865-36-5 U 51 71626-11-4 III 41 52918-63-5 II 30 62924-70-3 U 52 71751-41-2 Ib 23 53112-28-0 III 46 63278-33-1 O 60 72178-02-0 II 33 53780-34-0 II 34 63284-71-9 II 35 72490-01-8 U 52 54406-48-3 III 43 63333-35-7 Ia 21 72963-72-5 II 33 54593-83-8 Ia 21 63935-38-6 U 51 73250-68-7 U 54 54864-61-8 O 62 64249-01-0 II 27 73886-28-9 O 61 55179-31-2 U 49 64491-92-5 O 61 74051-80-2 III 47 55219-65-3 II 38 64628-44-0 U 57 74070-46-5 U 49 55283-68-6 U 51 64902-72-3 U 50 74115-24-5 III 42 55285-14-8 II 28 65907-30-4 Ib 24 74223-56-6 U 57 55290-64-7 II 30 65934-95-4 O 61 74223-64-6 U 54 55335-06-3 II 39 66063-05-6 U 55 74712-19-9 U 50 55511-98-3 O 59 66215-27-8 III 42 74738-17-3 U 52 55512-33-9 III 46 66230-04-4 II 31 74782-23-3 U 55 55634-91-8 III 41 66246-88-6 III 46 75736-33-3 O 60 55814-41-0 U 54 66332-96-5 U 53 76578-12-6 II 37 55861-78-4 II 34 66441-23-4 III 43 76608-88-3 O 62 56073-07-5 Ia 21 66841-25-6 II 38 76674-21-0 II 33 56073-10-0 Ia 21 66952-49-6 II 35 76738-62-0 II 36 56425-91-3 II 32 67129-08-2 III 45 77182-82-2 II 33 57018-04-9 U 57 67306-00-7 II 32 77458-01-6 II 37 57052-04-7 O 61 67375-30-8 II 29 77501-60-1 II 32 57130-91-3 O 62 67485-29-4 II 33 77732-09-3 II 36 57369-32-1 II 37 67564-91-4 III 43 78587-05-0 U 53 57375-63-0 O 62 67747-09-5 II 36 79241-46-6 III 44 57646-30-7 II 33 68038-71-1 III 41 79277-27-3 U 57 57837-19-1 II 34 68085-85-8 II 29 79538-32-2 Ib 25 57966-95-7 II 29 68228-20-6 O 62 79983-71-4 III 44 58011-68-0 U 56 68359-37-5 Ib 23 80060-09-9 III 42 58138-08-2 O 63 68505-69-1 III 41 80844-07-1 U 52 58667-63-3 O 61 69309-47-3 O 62 81334-34-1 U 53 58810-48-3 III 46 69327-76-0 III 41 81335-37-7 U 53

Pesticide active ingredients, which occur in Tables 1–8, in CAS no. order 77 CAS# CLASS PAGE CAS# CLASS PAGE CAS# CLASS PAGE 81335-77-5 U 53 96489-71-3 II 37 119446-68-3 II 30 81405-85-8 U 53 97886-45-8 U 51 119738-06-6 II 37 81412-43-3 II 39 98389-04-9 U 56 120068-37-3 II 32 81777-89-1 II 29 98730-04-2 U 49 120116-88-3 U 51 82097-50-5 U 57 98967-40-9 U 52 120162-55-2 U 49 82211-24-3 U 53 99283-00-8 III 42 120928-09-8 II 31 82558-50-7 U 53 99387-89-0 II 39 121451-02-3 U 55 82560-54-1 II 27 101007-06-1 U 49 122008-85-9 U 51 82657-04-3 II 27 101205-02-1 III 42 122453-73-0 II 28 83055-99-6 U 49 101463-69-8 III 44 122931-48-0 U 56 83121-18-0 U 57 102851-06-9 III 44 123312-89-0 III 46 83130-01-2 II 27 103055-07-8 III 45 123343-16-8 III 46 83164-33-4 III 42 103112-36-3 U 52 124495-18-7 U 56 83657-22-1 II 39 103361-09-7 III 44 125116-23-6 II 35 83657-24-3 II 31 104030-54-8 U 50 125401-75-4 III 41 83733-82-8 O 61 104040-78-0 III 44 126535-15-7 U 57 84087-01-4 III 46 104098-48-8 III 44 126833-17-8 U 52 84332-86-5 III 42 104206-82-8 III 45 130000-40-7 U 57 84496-56-0 U 50 104653-34-1 Ia 21 131341-86-1 U 52 85509-19-9 II 32 105024-66-6 U 56 131807-57-3 U 52 85785-20-2 III 43 106040-48-6 U 57 131860-33-8 U 49 86479-06-3 U 53 107534-96-3 II 38 131983-72-7 III 47 86598-92-7 U 53 108173-90-6 II 33 134098-61-6 II 32 87130-20-9 U 51 110235-47-7 U 54 135410-20-7 II 27 87310-56-3 O 59 110488-70-5 III 43 136191-56-5 U 56 87674-68-8 II 31 111479-05-1 U 56 136849-15-5 U 51 87757-18-4 O 61 111988-49-9 II 38 138164-12-2 II 28 87818-31-3 III 42 111991-09-4 U 55 138261-41-3 II 33 87820-88-0 II 38 112143-82-5 II 39 139528-85-1 U 54 88283-41-4 III 46 112226-61-6 III 44 139968-49-3 U 54 88485-37-4 II 33 112281-77-3 II 38 140923-17-7 U 53 88671-89-0 II 35 112410-23-8 U 57 141112-29-0 III 45 89269-64-7 II 32 112839-32-4 O 61 141517-21-7 U 57 90035-08-8 Ia 21 113036-87-6 U 55 142459-58-3 II 32 90134-59-1 III 44 113036-88-7 U 52 143390-89-0 III 45 90717-03-6 U 56 114311-32-9 III 44 144740-54-5 U 52 91465-08-6 II 29 114369-43-6 III 43 145701-21-9 U 51 94361-06-5 II 30 116170-30-0 O 62 145701-23-1 U 52 94593-91-6 U 50 116255-48-2 II 28 148477-71-8 III 47 95266-40-3 III 47 116714-46-6 U 55 149253-65-6 U 53 95465-99-9 Ib 23 117428-22-5 III 46 149877-41-8 U 49 95721-12-3 O 61 118134-30-8 II 37 150114-71-9 U 49 95737-68-1 U 56 118712-89-3 U 57 150824-47-8 II 35 96182-53-5 Ia 22 119168-77-3 II 38 153233-91-1 III 43

78 The WHO Recommended Classification of Pesticides by Hazard CAS# CLASS PAGE CAS# CLASS PAGE 153719-23-4 II 38 907204-31-3 III 44 155569-91-8 II 31 946578-00-3 II 38 156052-68-5 U 58 951659-40-8 II 32 158062-67-0 II 32 958647-10-4 III 44 161050-58-4 U 54 1031756-98-5 III 42 161326-34-7 III 43 1072957-71-1 II 27 165252-70-0 III 43 1228284-64-7 U 56 168316-95-8 III 47 1263133-33-0 III 47 173584-44-6 II 33 1315501-18-8 II 29 173662-97-0 III 45 1820573-27-0 Ib 23 178928-70-6 U 56 181274-17-9 U 52 181587-01-9 U 51 183675-82-3 III 46 187166-40-1 U 56 188425-85-6 U 49 203313-25-1 III 47 210880-92-5 II 29 219714-96-2 U 55 220899-03-6 U 54 239110-15-7 U 52 240494-70-6 III 45 240494-71-7 II 35 243973-20-8 III 46 260359-57-7 II 28 272451-65-7 III 44 318290-98-1 II 32 330459-31-9 U 57 348635-87-0 U 49 352010-68-5 U 49 372137-35-4 III 47 374726-62-2 U 54 400882-07-7 III 42 422556-08-9 III 46 473798-59-3 III 44 500008-45-7 U 50 517875-34-2 III 43 658066-35-4 III 44 688046-61-9 III 46 736994-63-1 U 50 858956-08-8 U 49 865318-97-4 III 41 874967-67-6 U 56 881685-58-1 II 34

Pesticide active ingredients, which occur in Tables 1–8, in CAS no. order 79 80 The WHO Recommended Classification of Pesticides by Hazard common name Final step: remove index TOC superscript via GREP, and put numbered ones into alph order

GREP to remove [ISO]: \[.+\]

but watch out for exceptions; paste INDEX. CLASSIFICATION OF those outside frame temporarily PESTICIDE ACTIVE INGREDIENTS then put back in after find/replace Ia = Extremely hazardous; Ib = Highly hazardous; II =Moderately hazardous; III = Slightly hazardous; U = Unlikely to present acute hazard in normal use; FM =Fumigant, not classified; O = Obsolete as pesticide, not classified.

COMMON NAME CLASS PAGE COMMON NAME CLASS PAGE Abamectin lb 23 Ammonium sulfamate III 41 Acephate II 27 Ancymidol III 41 Acetamiprid II 27 Anilazine III 41 Acetochlor III 41 Anilofos II 27 Acifluorfen II 27 Anthraquinone U 49 Aclonifen U 49 ANTU O 59 Acrinathrin U 49 Aramite O 59 Acrolein lb 23 Arsenous oxide O 59 Acrylonitrile FM 67 Asulam III 41 Alachlor II 27, 65 Athidathion O 59 Alanycarb II 27 Atraton O 59 Aldicarb la 21, 65 Atrazine III 41 Aldoxycarb O 59 Azaconazole II 27 Aldrin O 59, 65 Azamethiphos II 27 Allethrin II 27 Azimsulfuron U 49 Allidochlor II 27 Azinphos-ethyl lb 23 Alloxydim III 41 Azinphos-methyl lb 23, 65 Allyl alcohol lb 23 Aziprotryne O 59 Allyxycarb O 59 Azocyclotin II 27 Alpha-chlorohydrin, Azothoate O 59 see 3-Chloro-1,2-propanediol Ib 23 Azoxystrobin U 49 Alpha-cypermethrin II 29 Bacillus thuringiensis (Bt) III 41 Aluminium phosphide FM 67 Barban II 27 Ametoctradin III 41 Barium carbonate O 59 Ametryn II 27 Benalaxyl III 41 Amidithion O 59 Benazolin III 41 Aminocarb O 59 Bendiocarb II 27 Aminocyclopyrachlor U 49 Benfluralin U 49 Aminopyralid U 49 Benfuracarb II 27 Amisulbrom U 49 Benfuresate III 41 Amitraz II 27 Benodanil U 49 Amitrole U 49 Benomyl U 49, 65

INDEX. Classification of pesticide active ingredients 81 common name index TOC

COMMON NAME CLASS PAGE COMMON NAME CLASS PAGE Benoxacor U 49 Buprofezin III 41 Benquinox O 59 Butacarb O 59 Bensulfuron-methyl U 49 Butachlor III 41 Bensulide II 27 Butamifos II 28 Bensultap II 27 Butenachlor O 59 Bentazone II 27 Buthidazole O 59 Benzovindiflupyr lI 27 Buthiobate O 59 Benzoximate O 59 Butocarboxim lb 23 Benzoylprop-ethyl O 59 Butonate O 59 Benzthiazuron O 59 Butopyronoxyl O 59 Beta-cyfluthrin lb 23 Butoxycarboxim lb 23 BHC, see HCH II 33, 65 Butralin II 28 Bicyclopyrone U 49 Butroxydim II 28 Bifenazate U 49 Buturon O 59 Bifenox U 49 Butylamine II 28 Bifenthrin II 27 Butylate III 41 Bilanafos II 27 Cacodylic acid, see Dimethylarsinic acid II 31 Binapacryl O 59, 65 Cadusafos lb 23 Bioallethrin II 28 Calcium arsenate lb 23 Bioresmethrin U 49 Calcium cyanamide O 59 Biphenyl III 41 Calcium cyanide la 21 Bispyribac III 41 Camphechlor O 59, 65 Bisthiosemi O 59 Captafol la 21, 65 Bis(tributyltin) oxide II 28, 66 Captan U 50 Bitertanol U 49 Carbamorph O 59 Blasticidin-S lb 23 Carbanolate O 59 Borax III 41 Carbaryl II 28 Boscalid U 49 Carbendazim U 50 Brodifacoum la 21 Carbetamide U 50 Bromacil U 50 Carbofos, see Malathion III 45 Bromadiolone la 21 Carbofuran lb 23, 65 Bromethalin la 21 Carbon disulfide O 59 Bromobutide U 50 Carbophenothion O 59 Bromocyclen O 59 Carbosulfan II 28 Bromofenoxim II 28 Carboxin III 41 Bromophos-ethyl lb 23 Carpropamid U 50 Bromophos II 28 Cartap II 28 Bromopropylate U 50 Chinomethionat III 41 Bromoxynil II 28 Chlomethoxyfen O 59 Bromuconazole II 28 Chloralose II 28 Bronopol II 28 Chloramben O 59 Bufencarb O 59 Chloranil O 59 Bupirimate III 41 Chloranocryl O 59

82 The WHO Recommended Classification of Pesticides by Hazard COMMON NAME CLASS PAGE COMMON NAME CLASS PAGE Chloransulam methyl U 50 Chlorthal-dimethyl III 42 Chlorantraniliprole U 50 Chlorthiamid II 29 Chlorbenside O 59 Chlorthiophos O 60 Chlorbicyclen O 59 Chlozolinate III 42 Chlorbormuron O 59 Cinmethylin III 42 Chlorbufam O 59 Cinosulfuron U 50 Chlordane II 28 Cloethocarb O 60 Chlordecone O 59 Clofentezine III 42 Chlordimeform O 59, 65 Clofop O 60 Chlorethoxyfos la 21 Clomazone II 29 Chlorfenac II 28 Clomeprop U 50 Chlorfenapyr II 28 Clopyralid III 42 Chlorfenethol O 59 Clothianidin II 29 Chlorfenprop-methyl O 59 Cloxyfonac U 50 Chlorfenson O 59 Copper hydroxide II 29 Chlorfensulfide O 59 Copper oxychloride II 29 Chlorfenvinphos lb 23 Copper sulfate II 29 Chlorfluazuron U 50 Coumachlor O 60 Chlorflurenol U 50 Coumaphos lb 23 Chloridazon III 41 Coumatetralyl lb 23 Chlorimuron III 42 4-CPA II 29 Chlormebuform O 59 Credazine O 60 Chlormephos la 21 Crimidine O 60 Chlormequat chloride II 28 Crotoxyphos O 60 Chlormethiuron O 59 Crufomate O 60 Chlornitrofen O 59 Cryolite U 50 Chloroacetic acid II 28 Cuprous oxide II 29 Chlorobenzilate O 59, 65 Cyanazine II 29 Chloroneb U 50 Cyanofenphos O 60 Chlorophacinone la 21 Cyanophos II 29 Chloropicrin FM 67 Cyanthoate O 60 3-Chloro-1,2-propanediol lb 23 Cyantraniliprole U 50 Chloropropylate O 60 Cyazofamid U 51 Chlorothalonil U 50 Cyclaniliprole III 42 Chlorotoluron U 50 Cycloate III 42 Chloroxuron III 42 Cycloheximide O 60 Chlorphonium chloride II 29 Cycloprothrin U 51 Chlorphoxim O 60 Cyclosulfamuron U 51 Chlorpropham U 50 Cycloxydim III 42 Chlorpyrifos II 29 Cycluron O 60 Chlorpyrifos methyl III 42 Cyflumetofen III 42 Chlorquinox O 60 Cyfluthrin lb 23 Chlorsulfuron U 50 Cyhalofop U 51

INDEX. Classification of pesticide active ingredients 83 COMMON NAME CLASS PAGE COMMON NAME CLASS PAGE Cyhalothrin II 29 Dichlormid III 42 Cyhexatin II 29 Dichlorobenzene II 30 Cymoxanil II 29 1,2-Dichloropropane O 60 Cyometrinil O 60 1,3-Dichloropropene FM 67 Cypendazole O 60 Dichlorophen II 30 Cypermethrin II 29 Dichlorprop II 30 Cyphenothrin II 29 Dichlorvos lb 24 Cyproconazole II 30 Dichlozoline O 60 Cyprofuram O 60 Diclobutrazol O 60 Cypromid O 60 Diclofop II 30 Cyromazine III 42 Diclomezine U 51 2,4-D II 30 Dicloran III 42 2,4-DB II 30 Diclosulam U 51 Daimuron U 51 Dicofol II 30 Dalapon U 51 Dicrotophos lb 24 Daminozide U 51 Dieldrin O 60, 65 Dazomet II 30 Dienochlor III 42 DDT II 30, 65 Diethatyl O 60 DDVP, see Dichlorvos Ib 24 Diethofencarb U 51 DEET, see Diethyltoluamide III 42 Diethyltoluamide III 42 Delachlor O 60 Difenacoum la 21 Deltamethrin II 30 Difenoconazole II 30 Demephion-O O 60 Difenoxuron O 60 Demephion-S O 60 Difenzoquat II 30 Demeton-O O 60 Difethialone la 21 Demeton-S-methyl lb 24 Diflubenzuron III 42 Demeton-S-methylsulphon O 60 Diflufenican III 42 Demeton-S O 60 Dikegulac U 51 Desmedipham U 51 Dimefox O 60 Desmetryn O 60 Dimefuron III 43 Diafenthiuron III 42 Dimepiperate II 30 Dialifos O 60 Dimethachlor II 30 Di-allate O 60 Dimethametryn III 43 Diamidafos O 60 Dimethenamid II 31 Diazinon II 30 Dimethipin II 30 Dibromochloropropane O 60 Dimethirimol III 43 1,2-Dibromoethane FM 65, 67 Dimethoate II 31 Dibutyl phthalate O 60 Dimethomorph III 43 Dibutyl succinate O 60 Dimethylarsinic acid II 31 Dicamba II 30 Dimethyl disulfide II 31 Dichlobenil III 42 Dimethyl phthalate U 51 Dichlofenthion O 60 Dimetilan O 60 Dichlofluanid U 51 Dimexano O 60

84 The WHO Recommended Classification of Pesticides by Hazard COMMON NAME CLASS PAGE COMMON NAME CLASS PAGE Dinex O 60 EPN la 21 Diniconazole II 31 Epsilon-metofluthrin II 35 Dinitramine III 43 EPTC II 31 Dinobuton II 31 Erbon O 60 Dinocap II 31 Esfenvalerate II 31 Dinocton O 60 ESP (Oxydeprofos) O 60 Dinoseb O 60, 65 Esprocarb III 43 Dinoseb acetate O 60, 65 Etacelasil O 60 Dinotefuran III 43 Etaconazole O 60 Dinoterb lb 24 Ethalfluralin U 51 Dioxabenzophos O 60 Ethephon III 43 Dioxacarb O 60 Ethidimuron O 60 Dioxathion O 60 Ethiofencarb lb 24 Diphacinone la 21 Ethiolate O 60 Diphenamid II 31 Ethion II 31 Dipropetryn O 60 Ethiprole U 51 Dipropyl isocinchomerate U 51 Ethirimol U 51 Diquat II 31 Ethoate-methyl O 60 Disodium tetraborate, see Borax III 41 Ethofumesate U 51 Disulfoton la 21 Ethohexadiol O 60 Disul O 60 Ethoprophos la 21 Ditalimfos O 60 Ethyl butylacetylaminopropionate U 51 Dithianon II 31 Ethylene dibromide (EDB), Dithiopyr U 51 see 1,2-Dibromoethane FM 65, 67 Diuron III 43 Ethylene dichloride FM 65, 67 DMDS, see Dimethyl disulphide II 31 Ethylene oxide FM 65, 67 DNOC lb 24, 65 Etofenprox U 52 DNOC-ammonium Ib 24, 65 Etoxazole III 43 DNOC-potassium Ib 24, 65 Etridiazole III 43 DNOC-sodium Ib 24, 65 Etrimfos O 60 Dodemorph III 43 EXD O 61 Dodine II 31 Famoxadone U 52 Drazoxolon O 60 Famphur lb 24 DSMA, see Methylarsonic acid II 35 Fenamidone III 43 Edifenphos lb 24 Fenaminosulf O 61 Eglinazine O 60 Fenamiphos lb 24 Emamectin Benzoate II 31 Fenarimol III 43 Empenthrin [(1R) isomers] III 43 Fenazaflor O 61 Endosulfan II 31, 65 Fenazaquin II 31 Endothal-sodium II 31 Fenbuconazole III 43 Endothion O 60 Fenbutatin oxide III 43 Endrin O 60 Fenchlorazole U 52 EPBP O 60 Fenchlorphos O 61 Fenclorim U 52

INDEX. Classification of pesticide active ingredients 85 COMMON NAME CLASS PAGE COMMON NAME CLASS PAGE Fenfuram U 52 Fludioxonil U 52 Fenhexamid U 52 Fluenetil O 61 Fenitropan O 61 Fluensulfone II 32 Fenitrothion II 31 Flufenacet II 32 Fenobucarb II 32 Flufenoxuron III 44 Fenoprop (Silvex) O 61 Flumetralin U 52 Fenothiocarb II 32 Flumetsulam U 52 Fenoxaprop-ethyl III 43 Flumioxazin III 44 Fenoxaprop-p-ethyl III 43 Fluometuron U 52 Fenoxycarb U 52 Fluopicolide U 52 Fenpiclonil U 52 Fluopyram III 44 Fenpicoxamid III 43 Fluoroacetamide lb 24, 65 Fenpropathrin II 32 Fluorodifen U 52 Fenpropidin II 32 Fluoroglycofen II 32 Fenpropimorph III 43 Fluoromide O 61 Fenpyrazamine III 44 Fluotrimazole O 61 Fenpyroximate II 32 Flupropanate U 52 Fenson O 61 Flupyradifurone II 32 Fensulfothion O 61 Flupyrsulfuron U 52 Fenthiaprop O 61 Flurenol U 52 Fenthion II 32 Fluridone U 53 Fentin acetate II 32 Flurochloridone III 44 Fentin hydroxide II 32 Fluroxypyr U 53 Fenuron O 61 Flurprimidol II 32 Fenuron-TCA O 61 Flusilazole II 32 Fenvalerate II 32 Fluthiacet U 53 Ferbam U 52 Flutianil III 44 Ferimzone II 32 Flutolanil U 53 Fipronil II 32 Flutriafol II 33 Flamprop-M III 44 Fluvalinate II 33 Flamprop O 61 Fluxapyroxad III 44 Flazasulfuron III 44 Fluxofenim II 33 Flocoumafen la 21 Folpet U 53 Flonicamid II 32 Fomesafen II 33 Florasulam U 52 Fonofos O 61 Fluazifop O 61 Formaldehyde FM 67 Fluazifop-p-butyl III 44 Formetanate lb 24 Flubendiamide III 44 Formothion II 33 Flubenzimine III 44 Fosamine III 44 Flucarbazone-sodium U 52 Fosetyl-aluminium U 53 Fluchloralin II 32 Fosetyl U 53 Flucycloxuron U 52 Fosmethilan O 61 Flucythrinate lb 24 Fosthietan O 61

86 The WHO Recommended Classification of Pesticides by Hazard COMMON NAME CLASS PAGE COMMON NAME CLASS PAGE Fuberidazole II 33 Iminoctadine II 33 Furalaxyl II 33 Imiprothrin II 33 Furathiocarb lb 24 Inabenfide U 53 Furconazole-cis O 61 Indoxacarb II 33 Furmecyclox O 61 Iodomethane, see Methyl iodide II 35 Gamma-HCH, Lindane II 33, 34 Ioxynil II 34 Gibberellic acid U 53 Ioxynil octanoate II 34 Glufosinate-ammonium II 33 Ipazine O 61 Glyodin O 61 Iprobenfos II 34 Glyphosate III 44 Iprodione III 44 Glyphosine O 61 Iprovalicarb U 53 Griseofulvin O 61 IPSP O 61 Guazatine II 33 Isazofos O 61 Halacrinate O 61 Isobenzan O 61 Halofenozide III 44 Isobornyl thiocyano acetate O 61 Haloxydine O 61 Isocarbamid O 61 Haloxyfop II 33 Isocil O 61 HCH II 33, 65 Isodrin O 61 Heptachlor O 61, 65 Isofenphos O 61 Heptenophos lb 24 Isomethiozin O 61 Heptopargil O 61 Isonoruron O 61 Hexachloroacetone O 61 Isoprocarb II 34 Hexachlorobenzene la 21, 65 Isopropalin O 61 Hexaconazole III 44 Isoprothiolane II 34 Hexaflumuron U 53 Isoproturon II 34 Hexaflurate O 61 Isopyrazam II 34 Hexazinone II 33 Isothioate O 61 Hexythiazox U 53 Isouron II 34 Hydramethylnon II 33 Isoxaben U 53 Hydrogen cyanide FM 67 Isoxaflutole III 45 Hydroprene U 53 Isoxapyrifop O 61 2-Hydroxyethyl octyl sulphide U 53 Isoxathion lb 24 Hydroxyquinoline sulfate O 61 Jodfenphos O 61 Hymexazol III 44 Karbutilate O 61 Imazalil II 33 Kasugamycin U 53 Imazamethabenzmethyl U 53 Kelevan O 61 Imazamox III 44 Kinoprene O 61 Imazapic III 44 Kresoxim-methyl III 45 Imazapyr U 53 Lambda-cyhalothrin II 29, 34 Imazaquin U 53 Lead arsenate lb 24 Imazethapyr U 53 Lenacil U 54 Imibenconazole U 53 Leptophos O 61 Imidacloprid II 33 Lindane, see Gamma-HCH II 33, 65

INDEX. Classification of pesticide active ingredients 87 COMMON NAME CLASS PAGE COMMON NAME CLASS PAGE Linuron III 45 Methamidophos lb 24, 65 Lufenuron III 45 Methasulfocarb II 35 Lythidathion O 61 Methazole O 61 Magnesium phosphide FM 67 Methidathion lb 24 Malathion III 45 Methiocarb lb 25 Maldison, see Malathion III 45 Methiuron O 61 Maleic hydrazide U 54 Methomyl lb 25 Malonoben O 61 Methoprene U 54 Mancozeb U 54 Methoprotryne O 61 Mandestrobin III 45 Methoxychlor U 54 Mandipropamid U 54 Methoxyethylmercury silicate O 61 Maneb U 54 Methoxymethyl mercury chloride O 61 MCPA II 34 Methoxyphenone O 61 MCPA-thioethyl II 34 Methozyfenozide U 54 MCPB II 34 Methylarsonic acid II 35 Mebenil O 61 Methyl bromide FM 67 Mecarbam lb 24 Methyldymron III 45 Mecarbinzid O 61 Methyl iodide II 35 Mecarphon O 61 Methyl isothiocyanate II 35 Mecoprop II 34 Methylmercury dicyandiamide O 61 Mecoprop-P II 34 Methyl-parathion, see Parathion-methyl lb 22, 66 Medinoterb acetate O 61 Metiram U 54 Mefenacet U 54 Metobromuron III 45 Mefluidide II 34 Metofluthrin III 45 Menazon O 61 Metolachlor III 45 Mepanipyrim U 54 Metolcarb II 35 Mephospholan O 61 Metosulam U 54 Mepiquat II 34 Metoxuron III 45 Mepronil U 54 Metrafenone U 54 Meptyldinocap III 45 Metribuzin II 35 Mercuric chloride la 21, 65 Metsulfovax O 62 Mercuric oxide lb 24, 65 Metsulfuron methyl U 54 Mercurous chloride II 34, 65 Mevinphos la 21 Mesotrione III 45 Mexacarbate O 62 Metaflumizone U 54 Mipafox O 62 Metalaxyl II 34 Mirex O 62 Metaldehyde II 34 Molinate II 35 Metamitron II 34 Monalide III 45 Metam-sodium II 35 3-Monochloro-1,2-propanediol (3-MCPD), Metazachlor III 45 see 3-Chloro-1,2-propanediol Ib 23 Metconazole II 35 Monocrotophos lb 25, 66 Methabenzthiazuron III 45 Monolinuron III 45 Methacrifos II 35 Monuron O 62 Monuron-TCA O 62

88 The WHO Recommended Classification of Pesticides by Hazard COMMON NAME CLASS PAGE COMMON NAME CLASS PAGE Morfamquat O 62 Parafluron O 62 Myclobutanil II 35 Paraquat II 36 Myclozolin O 62 Parathion la 22, 66 Nabam II 35 Parathion-methyl la 22, 66 Naled II 35 Paris green lb 25 Naphthalene II 35 PCP, see Pentachlorophenol lb 25, 65 Naphthalic anhydride O 62 Pebulate II 36 2-(1-Naphthyl) acetamide U 54 Penconazole III 46 1-Naphthylacetic acid III 45 Pencycuron U 55 Napropamide U 54 Pendimethalin II 36 Naptalam U 54 Penoxsulam U 55 2-Napthyloxyacetic acid II 35 Pentachlorophenol lb 25, 65 Neburon U 54 Pentanochlor U 55 Niclosamide U 54 Penthiopyrad III 46 Nicosulfuron U 55 Perfluidone O 62 Nicotine lb 25 Permethrin II 36 Nitenpyram II 35 Phenisopham O 62 Nitralin O 62 Phenkapton O 62 Nitrapyrin II 35 Phenmedipham U 55 Nitrofen III 45 Phenobenzuron O 62 Nitrothal-isopropyl U 55 Phenothrin U 55 N-octylbicycloheptene dicarboximide III 45 Phenthoate II 36 Norbormide O 62 Phenylmercury acetate la 22 Norflurazon II 35 Phenylmercurydimethyl-dithiocarbamate O 62 Noruron O 62 Phenylmercury nitrate O 62 Novaluron U 55 2-Phenylphenol III 46 Noviflumuron U 55 Phorate la 22, 65 Nuarimol II 35 Phosacetim O 62 Octhilinone II 36 Phosalone II 36 Ofurace III 46 Phosdiphen O 62 Omethoate lb 25 Phosfolan O 62 Oryzalin U 55 Phosmet II 36 Oxabetrinil U 55 Phosphamidon la 22, 66 Oxadiazon U 55 Phosphine FM 67 Oxadixyl II 36 Phosphorus acid U 55 Oxamyl la 21 Phoxim II 36 Oxapyrazon O 62 Phthalide U 55 Oxine-copper U 55 Picloram U 55 Oxycarboxin III 46 Picoxystrobin III 46 Oxydemeton-methyl lb 25 Pimaricin III 46 Oxydisulfoton O 62 Pindone O 62 Oxyfluorfen U 55 Pinoxaden III 46 Paclobutrazol II 36 Piperonyl butoxide U 55

INDEX. Classification of pesticide active ingredients 89 COMMON NAME CLASS PAGE COMMON NAME CLASS PAGE Piperophos II 36 Pyracarbolid O 62 Piproctanyl O 62 Pyraclofos II 37 Pirimicarb II 36 Pyrazolynate U 56 Pirimiphos-ethyl O 62 Pyrazophos II 37 Pirimiphos-methyl II 36 Pyrazosulfuron U 56 Potassium cyanate O 62 Pyrazoxyfen II 37 Prallethrin II 36 Pyrethrins II 37 Pretilachlor U 55 Pyridaben II 37 Primisulfuron U 55 Pyridaphenthion II 37 Probenazole III 46 Pyridate III 46 Prochloraz II 36 Pyridinitril O 62 Procymidone U 55 Pyrifenox III 46 Prodiamine U 55 Pyrimethanil III 46 Profenofos II 36 Pyriminobac U 56 Profluralin O 62 Pyriofenone III 46 Proglinazine O 62 Pyriproxyfen U 56 Promacyl O 62 Pyrithiobac sodium III 46 Promecarb O 62 Pyroquilon II 37 Prometon III 46 Pyroxsulam III 46 Prometryn III 46 Quinacetol sulfate O 62 Propachlor II 36 Quinalphos II 37 Propamocarb U 56 Quinclorac III 46 Propanil II 36 Quinmerac U 56 Propaphos O 62 Quinoclamine II 37 Propaquizafop U 56 Quinonamid O 62 Propargite III 46 Quinoxyfen U 56 Propazine U 56 Quintozene U 56 Propetamphos lb 25 Quizalofop II 37 Propham U 56 Quizalofop-p-tefuryl II 37 Propiconazole II 36 Resmethrin III 46 Propineb U 56 Rimsulfuron U 56 Propoxur II 37 Rotenone II 37 Propylene oxide II 37 Ryania O 62 Propyl isome O 62 Saflufenacil III 47 Propyzamide U 56 Salicylanilide O 62 Prosulfocarb II 37 Schradan O 62 Prothioconazole U 56 Secbumeton O 62 Prothiofos II 37 Sedaxane U 56 Prothoate O 62 Sesamex O 62 Proxan O 62 Sethoxydim III 47 Pydanon O 62 Sevin, see Carbaryl II 28 Pydiflumetofen U 56 Siduron U 56 Pymetrozine III 46 Silafluofen U 56

90 The WHO Recommended Classification of Pesticides by Hazard COMMON NAME CLASS PAGE COMMON NAME CLASS PAGE Simazine U 56 Terbacil U 57 Simetryn II 37 Terbucarb O 62 Sodium arsenite lb 25 Terbufos la 22 Sodium chlorate II 37 Terbumeton II 38 Sodium cyanide lb 25 Terbuthylazine III 47 Sodium fluoride II 37 Terbutryn III 47 Sodium fluoroacetate la 22 Tetrachlorvinphos III 47 Sodium hexafluorosilicate O 62 Tetraconazole II 38 Spinetoram U 56 Tetradifon U 57 Spinosad III 47 Tetramethrin U 57 Spirodiclofen III 47 Tetrasul O 62 Spirotetramat III 47 Thallium sulfate lb 25 Spiroxamine II 37 Thiabendazole III 47 Strychnine lb 25 Thiacloprid II 38 Sulfallate II 38 Thiamethoxam II 38 Sulfluramid II 38 Thiazafluron II 38 Sulfometuron U 57 Thicyofen O 62 Sulfotep la 22 Thidiazuron III 47 Sulfoxaflor II 38 Thifensulfuron-methyl U 57 Sulfoxide O 62 Thifluzamide U 57 Sulfuryl fluoride FM 67 Thiobencarb II 38 Sulphur III 47 Thiocyclam II 38 Sulprofos O 62 Thiodicarb II 38 SWEP O 62 Thiofanox lb 25 2,4,5-T O 62, 65 Thiometon lb 25 tau-Fluvalinate III 44 Thionazin O 62 2,3,6-TBA II 38 Thiophanate-methyl U 57 TBTO, see Bis(tributyltin) oxide II 28, 66 Thiophanate O 62 TCA-ethadyl O 62 Thiophos,see Parathion Ib 22, 66 TCA (acid) II 38 Thioquinox O 62 TCA (sodium salt) III 47 Thiram II 38, 65 TDE O 62 Tiocarbazil U 57 Tebuconazole II 38 Tioxazafen U 57 Tebufenozide U 57 Tolclofos-methyl U 57 Tebufenpyrad II 38 Tolylfluanid U 57 Tebupirimfos la 22 Toxaphene O 62, 65 Tebutam U 57 Tralkoxydim II 38 Tebuthiuron II 38 Tralomethrin II 38 Tecnazene U 57 Transfluthrin U 57 Teflubenzuron U 57 Triadimefon II 38 Tefluthrin lb 25 Triadimenol II 38 Temephos III 47 Tri-allate III 47 TEPP O 62 Triamiphos O 62

INDEX. Classification of pesticide active ingredients 91 COMMON NAME CLASS PAGE Triapenthenol O 62 Triarimol O 62 Triasulfuron U 57 Triazamate II 39 Triazophos lb 25 Tribenuron U 57 Tributyltin oxide, see Bis(tributyltin) oxide II 28, 66 Tricamba O 62 Trichlamide O 63 Trichlorfon II 39, 65 Trichloronat O 63 Triclopyr II 39 Tricyclazole II 39 Tridemorph II 39 Tridiphane O 63 Trietazine III 47 Trifenmorph O 63 Trifloxystrobin U 57 Triflumezopyrim III 47 Triflumizole II 39 Triflumuron U 57 Trifluralin U 57 Triflusulfuron-methyl U 57 Triforine U 58 Trimethacarb O 63 Trinexapac-ethyl III 47 Triticonazole III 47 Undecan-2-one III 47 Uniconazole II 39 Validamycin U 58 Vamidothion lb 25 Vernolate II 39 Vinclozolin U 58 Warfarin lb 25 XMC II 39 Xylylcarb II 39 Zeta-cypermethrin II 29 Zinc phosphide lb 25 Zineb U 58 Ziram II 39 Zoxamide U 58

92 The WHO Recommended Classification of Pesticides by Hazard

The WHO Recommended Classi cation of Pesticides by Hazard and Guidelines to Classi cation 2019