WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES Lal. World Journal of Pharmacy and Pharmaceutical Sciences SJIF Impact Factor 7.632 Volume 8, Issue 11, 308-316 Review Article ISSN 2278 – 4357

CRITICAL REVIEW OF ANUKTA DRAVYA “LAHSUN BEL (

ALLIACEA)

Dr. Lal*

India.

ABSTRACT Article Received on 09 Sep. 2019, Medicinal are scientifically documented in Ayurvedic literature

Revised on 30 Sep. 2019, based on the sound fundamentals of rasa (Taste), guna (Property), Accepted on 21 Oct. 2019,

DOI: 10.20959/wjpps201911-14670 virya (Potency), vipaka (Metabolism) and prabhava (Specific

action).Vedic to Samhita and Samhita to Nighantu Kala evidenced the chronological upgradation of medicinal plants. Inclusion of new *Corresponding Author Dr. Lal dravyas (Drugs) has been the tradition of Ayurveda. Nighantukaras India. especially played a great role in this respect e.g. However, many folklore and exotic plants existing in India have not been yet stated in

Ayurvedic Samhitas or Nighantus, Such are turned as „anukta dravya’. These may include

dravya like cissus rependa Vahl. (Pani bel), Lam. (Lahsun bel) etc. Day by day important medicinal plants are depleting but fortunately we have dense folklore herbs which should be thoroughly explored, studied and included in Ayurvedic pharmacopeia. Mansoa alliacea (Lam.) is one of anukta dravya. Hence present study of this article review of Mansoa alliacea, uses of M. alliacea, ethnobotanical information are described.

KEYWORDS: Mansoa alliacea, Anukta dravya, Lahsun bel.

INTRODUCTION Mansoa alliacea Lam. (Family ) is a native from Amazonian basin. This plant is mainly found in Southern America but it is also found tropical rain forest region in India. There are total 11 species. Mansoa alliacea have several vernacular names like – „Fake garlic‟ or „Wild garlic‟ in English[1], „Ajos sacha‟ in Spain[1], „Garlic Vine‟ in English[2], Other - Bejuco de ajo, Mata de ajo; Garlic vine[2], Bejuco De Ajo in Spanish[2], Lasun Vel, Lasnya in Marathi[3], Lahan Bel in Hindi.[3] Mansoa alliacea is a native Amazonian plant belonging to the family of Bignoniaceae, its scientific name is Mansoa alliacea (Lam.) A.

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Gentry but has been classified with several synonyms.[4] The name ajo sacha means „false garlic‟, due to the characteristic garlic smell molecules present into the leaves.[5] Generally leaves are used in the preparation of infusion or decoction. Roots are used in preparation of cold maceration and tincture and generally taken as a whole body tonic.[6,7]

AIM AND OBJECTIVES The present study deals with review of Mansoa alliacea (Lam.) from different literatures, journals and websites.

Botanical description Trees (Nyctocalos a large climber, Amphicome a herb). Leaves opposite, rarely whorled (in Amphicome alternate), 1-2-3 pinnate or sometime sub divided. Panicles or racemes terminal, rarely on short lateral branches, bracts inconspectious, flowers showy, hermaphrodite, irregular. Calyx gamosepalous, campanulate (in the Indian species), valvate, spathaceous or 2-5 lobed. Corolla tubular-ventricose, mouth 2-lipped, lobes 5, subequalor slightly unequal, bilabiately imbricate in the bud. Stamens 4, didynamous, rudiment of the fifth often present (5 subequal in Oroxylum), inserted at the point where the corolla-tube is suddenly swollen, filaments linear, glabrous or hairy only at the base, anthers 2-celled, included or rarely shortly exserted, cells elliptic or narrowly oblong, dehiscing by longitudinal slits, parallel or divaricate. Disc usually cushion-like or annular. Ovary subsessile, 2-celled, style long glabrous, stigma of 2 elliptic lobes, ovules in many rows (in Amphicomeih. 1-2 rows) grouped in a double series in each cell, anatropous. Capsule mostly elongate, loculicidally or septicidally2-valved, septum in fruit enlarged, deciduous together with the placentas. Seeds compressed discoid (rarely subtrigonous) prominently winged, exalbuminous. Species 450, in the tropics of the whole world, a few in the warm temperate zones of both hemispheres.[8]

Action and uses: Traditional, magical and ritual uses are mentioned in Table No.1.

Table No. 1: Traditional medicine, magical and ritual uses of M. alliacea. Country Ethnic group Traditional medicine, magical and ritual uses Brazil Not reported Cold, fever[9] Abdominal pain, fever, intestinal parasites, Bolivia Tacana rheumatic pain, ritual uses[10] Shipibo -Conibo y Perú Anti-malarial[11] Ashaninka y mestizo Ecuador Kichwa Food spice[12] Not reported Not reported Analgesic, anti-arthritic, anti-inflammatory, antipyretic, anti-

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rheumatic, antitussive, depurative, purgative, vermifuge.[13] Analgesic, anti-rheumatic, anti-arthritic, antipyretic, colds, constipation, cough, epilepsy, fevers, food, Surinam headache, insecticidal, malaria, mystical and magical rituals, Brazil Not reported nausea, pneumonia, rheumatic pains, treatment of pains and Guianas muscular fatigue, tonic, useful for healthy pregnancy, vermifuge.[14] San Martin Quechuas Peru Rheumatism[15] or Lamas Quec Huas Peru Yanesha Fever, flu, rheumatic pain[16] Panama Téribe Aggressive dementia[17] Brazil Not reported Fly repellant (ethnoveterinary reports)[18] Brazil Not reported Magical and ritual uses (evil eye)[19] Brazil Riverine communities Amoeba, bath, cough, flu, pain of Head[20] Analgesic, antiarthritic, anti-inflammatory, South America antipyretic, antirheumatic, colds, constipation, depurative, Not reported (Brazil, Peru) nausea, pneumonia and respiratory disorders, purgative, vermifuge.[21] Ecuador Achuar Cold[22] Ecuador Waorani Magic rituals, Topical anesthetic.[23] Analgesic, anti-inflammatory, antirheumatic, body aches and Not reported Not reported pain, muscle aches, rheumatism, treatment for arthritis, injuries and pain[24] Ecuador Kichwa Infections, muscular system disorders, respiratory diseases[25] Ecuador Kichwa and Mestizo Anesthetic, cold, muscle pain, ritual use[26] Magical and ritual use-Limpeza do corpo (Body cleaning);- Brazil Caruaru Proteção (Protection)[27] Riverine Magical and ritual use-Doença-do-ar (air diseases);-espante Brazil Inhabitants (fright);-ventocaído (fallen wind);-derrame (leakage)[28,29]

Ethnobotanical information of M. alliacea In peru Aerial parts as Tinture/oral used for bodyaches and rheumatism. Aerial parts/Suriname is used for fever, colds, rheumatic pains and as a vermifuge in Human adult. In Brazil bark is used as analgesic, antipyretic, antirheumatic, cold and fever in form of Infusion/oral.[30] In Guayanas Bark is used for fever and general weakness as Decoction. In Peru Shipido-Conibo Indians use it for rheumatism, arthritis, to prevent a cold, uterine disorders, inflammation, and epilepsy and as a regenerative, energy tonic. Shipido-Conibo Indians give it to dogs to make them good hunters. Shipibo-Conibo Indians hang bunches of leaves inside their house to ward off evil spirits and to bring good luck.[30] Shipibo-Conibo Indians use it for rheumatism, arthritis, inflammation, epilepsy and as a regenerative and energy tonic.[31] In Peru bark decoction is used for epilepsy. Also use for abdominal pain and fever. In Peru bark or leaf is used in bath for fever, nervous shock, and skin damage.[31] Smoke the leaves (as a smudge) in the house to drive away bad spirits. Prepare in a bath to

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get of bad spirits and protect against injury.[32] Used in baths for asthama and smoker‟s. In Amazon region leaf is used in bath to relieve „Manchiari‟ (a nervous stated caused by terror or sudden shock) especially in children. Tapajos Indians use it for bodyache and flu.[41] Used for arthritis and rheumatism and headaches as Poultice/External.[32] Used for rheumatism as Decoction/External. Used for cold and pneumonia as Infusion/Oral.[33] In Peru people Hung leaf bunch around the house as an and repellant.[38] Used for rheumatism and chronic arthritis. Very good in chronic and difficult cases as Infusion/Oral/ Poltice/External.[38] The Esa‟ eja Indian use it against cold, the Amuesha use it to increase fertility as Infusion/Oral.[30] Used for muscle aches and pains as Decoction /External.[32] In Guyana Wayapi Indians use Leaf and stem it in antipyretic bath. Infusion/External.[35] Also used as a decoction for bath to treat fever, influenza, rheumatism and cold.[33] In peru Leaf+ stem is used for fever as Decoction/Oral.[36,37] Used for malaria. As Decoction/Oral in Human Adult.[36] Leaf stem is used in Guyana to relive fatigue and small needle-like cramps as Decoction /External.[35] Leaf and stem is used in Guyana as External wash to treat fatigue lameness and lumbago.[33] Leaf, stem, Suriname and piece of stem in a glass of water is drunk in the last month of pregnancy for a healthy confinement as Maceration/Oral.[33] In Amazon Palikur Indians use whole plant to protect themselves from bad spirits.[41] In Colombia Plant is used for pulmonary aliments as Infusion/Oral.[30] Used as an antirhumatic, Antiarthritic and purgative as Decoction/Oral.[37] In Peru whole plant is used as an adjunctive in Ayahuasca for body/blood detoxication and to get rid of evil spirit as Decoction/Oral.[38] Used as a mosquito repellant Smoked in fires.[37] In Venuzuela whole plant is used as an emetic.[39]

Phytochemicals analysis of Mansoa alliacea Leaves - Essential oil extract of leaves reveals the present of Allyl methyl trisulfide, allyl propyl trisulfide, dithiacyclopentene, allylpropyl disulfide, allyl methyltrisulfide, allyl isobutylsulfide, allyl isobutyl disulfide, diallylmonosulfide, diallyl disulfide, diallylsulfide, diallyltrisulfide, diallyltetrasulfide, 3-vinyl-1, 2-dithi-4-en, allyl tri-sulfite, tetrasulfite, di-2- propinil, trisulfide, di-2-propenyl, 1-octen-3-ol, allyl methyl disulfide, allyl methyltetrasulfide, propenyl propyltrisulfide, 3-vinyl-1, 2-dithi- 4-ene, 3-vinyl-1, 2-dithi-5- ene, trithiacyclohexene, 2-methyl-2-pentenal, cis dipropenyl disulfide, trans-dipropenyl disulfide, methyl salicylate, 3, 4-dimethyl-2, 3dihydrothiophen-2-one, nonanethiol, diisoamyl disulfide.[37,38,39,40]

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Flower - Petroleum extract of leaf found n- alkanes C25-C35, n-alkanols, 24 ethylcholest-7- ene-3β-ol, fucosterol, 3β -hydroxyurs -18-en-27-oic acid, 32 hydroxyhexatriaconta-4-one, 19hydroxyhexatriacontan-18-one, 34-hydroxymethylheptatriacontan-5 one, pentatriacont-1- en-17-ol, β-sitosterol, stigmasterol.[39]

Essential oil extract of flower shows the presence of diallyl disulfide, diallyltetrasufide, diallyltrisulfide, 1-octen-3-ol. Methanol extract of flower shows the presence of Alliin, β- amyrin, apigenin, apigenin-7-glucoside, apigenin-7-glucuronide scutellarein -7-glucuronide, apigenin-7-glucurony glucuronide, apigenin-7-Omethylglucuronide, cyanidin-3rutinoside, β- sitosterol, β-sitosteryld-glucoside, luteolin, 7 Omethylscutellarein, ursolic acid.[38,39]

Stem Bark - Dichloromethane phase of the methanol extract of stem bark reveals the presence of 9-methoxy-α-lapachone, 4-hydroxy-9-methoxy-α-lapachone.[40]

DISCUSSION Ayurveda describes usage of many medicinal plants. Multiple medicinal plants are in folklore use with satisfactory results like Mansoa alliacaea (Lam.). Hence to tackle newly emerging disease study of anukta dravya becomes essential. The search for better and safer ways of relieving rheumatic pain is herbology. It would seem most people agree with the importance of pain relief for these analgesic herbs, some are the best loved and most popular remedies. Some uses for Analgesic herbs are in headaches, cold, fever, toothaches, sore muscles lower back pain and neuralgia. This review opens the way for the research of the active molecules from these plants, their characterisation and isolation. Table 1 shows uses of M. alliacea. Experts of Ayurveda, and traditional healers should come together to give a proper place to anukta dravya in Ayurvedic pharmacopoeia.

CONCLUSION India is blessed with dense plant population carrying medicinal importance. Most of them are well documented in Ayurvedic classics. Scientific study and documentation of folklore are very essential. In Ayurvedic classical literature M. alliacae (Lam.) was not referred in literature. In modern literature, technical data report, there have been mentioned that M. alliacae is ethnomedicinally used in swelling & inflammatory condition of the skin, rheumatic arthritis.

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