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Mansoa Alliacea Amazon Blend Clinical Information AJO SACHA (mansoa alliacea) is a wild jungle garlic said to have originated in the Amazon rainforest, ​ ​ but it has since spread to several other parts of the world with similar climates. It has been used by indigenous communities for centuries as a “spiritual” plant capable of driving away evil spirits, clearing 1,13 negative energy from the mind and body, and used for good luck. ​ Ajo Sacha contains several of the ​ 3,4 main sulfur compounds that garlic does, such as allicin and ursolic acid. ​ These compounds have ​ been well documented within evidence based literature demonstrating antimicrobial, anti-inflammatory, and antioxidant properties, as well as cellular protective actions in the lungs, kidneys, liver, and brain. Clinical Efficacy and Research Related to Ajo Sacha Antimicrobial effects. Antimicrobial actions against plant viruses, fungi, and bacteria have been ​ reported which may explain why traditionally Ajo Sacha has been used to treat colds, flu, pneumonia 5,6,10 and other upper respiratory infections. ​ An in-vitro assay study in 2005 showed that the antifungal ​ action of the Ajo Sacha leaf extract was as potent as a commonly used antifungal drug, clotrimazole, at 11 very low doses. ​ The presence of coumarins in the Ajo Sacha plant, along with its phenolic content, is ​ 12 associated with the medicinal actions attributed to this plant. ​ Studies have cited several popular ​ medicinal uses for the treatment of cough, nausea, fever, diarrhea, among others.4,12,13,14 ​ Anti-inflammatory effects. A study performed in 2009 showed that the essential oil of this species is ​ composed of various sulfur compounds, which showed anti-inflammatory activity and may be 4 responsible for the medicinal actions of the plant. ​ Ajo Sacha has also been shown to inhibit COX, ​ which is an enzyme required in the inflammatory process. Inhibition of COX can provide relief from the symptoms of inflammation and pain as demonstrated through Ajo Sacha’s use for the treatment of 7 arthritis and rheumatism. M​ ore recent reports show that Ajo Sacha’s anti-inflammatory actions can also ​ be explained by the plant’s ability to regulate the immune system and decrease the production of immune cells that cause inflammation.1,8 ​ Antioxidant effects. Several studies have reported very strong antioxidant actions and attributed them ​ 3,9,14 to isolated and tested organosulfur compounds, ursolic acid, and anthocyanin. ​ The sulfur ​ ​ compounds in Ajo Sacha have been reported to lower cholesterol and have antioxidant effects in both humans and animals.2,8,10 ​ Cellular Protective effects. Ajo sacha is a rich source of a well-known natural terpene, called ursolic ​ acid, which has been documented with cellular protective actions in the lungs, kidneys, liver and brain.3 ​ Under physiological concentrations in mice, ursolic acid has been shown to induce programmed cell death in defective red blood cells, reduce muscle atrophy while stimulating muscular growth, shown potential for cardioprotection, and induce neural regeneration after sciatic nerve injury.10,15 16, 17 ​ SANGRE DE GRADO (croton lechleri) is a medium-sized tree found in many regions of South ​ America. It is often called "Dragon's Blood" due to a red latex or sap that is extracted upon felling the ​ tree and scoring the bark. This latex is the primary part of Sangre de Grado used for medicinal purposes due to the protective antioxidant phenols and anti-inflammatory compounds found within.22,23 ​ ​ Reviews of these chemical constituents of the sap have been widely published and scientists have attributed many of the biologically active properties of the sap to two main “active” constituents: an 18-21 alkaloid named taspine and a lignan named dimethylcedrusine. A​ purified constituent of sangre de ​ ​ ​ ​ grado known as crofelemer (Mytesi, formerly Fulyzaq and SP-303) is an FDA-approved drug for the 18,22 treatment of non-infectious diarrhea in HIV and AIDS patients receiving antiretroviral drugs. F​ or ​ centuries, the sap has been painted on wounds to stop bleeding, accelerate healing, and to seal and protect injuries from infection. It is used externally by indigenous tribes and local people in Peru for wounds, fractures, and hemorrhoids, internally for gastrointestinal problems such as hemorrhoids.19-21 ​ Clinical Efficacy and Research Related to Sangre de Grado Antibacterial and Antiviral effects. Several phenolic compounds and diterpenes, as well as the ​ 24-26 essential oil from the plant, have demonstrated antibacterial activity in animal studies. ​ A​ ntiviral ​ effects have also been seen with Sangre de Grado extracts and may be related to viral penetration of ​ ​ the cell membrane. Crofelemer demonstrates broad in vitro activity against DNA and RNA viruses, including respiratory syncytial virus, influenza A, parainfluenza virus, herpesvirus types 1 and 2, and 27-29 hepatitis A and B. ​ T​ he mechanism of sangre de grado's antibacterial effects is unclear. ​ Analgesic effects. In vitro and animal research suggests that Sangre de Grado sap blocks the ​ activation of sensory afferent nerves at the prejunctional and postjunctional levels, leading to relief of pain, burning, and itching caused by neurogenic inflammation.19,30,31 ​ Anti-inflammatory effects. The alkaloid constituent taspine, isolated from Sangre de Grado, has ​ demonstrated anti-inflammatory effects in animal models of pain and inflammation, with anti-inflammatory activity similar to or greater than indomethacin, an FDA approved nonsteroidal anti-inflammatory drug (NSAID).19,32 ​ Gastrointestinal effects. Animal research suggests that Sangre de Grado promotes the healing of ​ gastric ulcers. This may be explained by reduced gene expression of pro-inflammatory cytokines, including tumor necrosis factor-alpha (TNF-alpha), inducible nitric oxide synthase (iNOS), interleukin (IL)-1beta, IL-6, and cyclooxygenase-2 (COX-2), which has been demonstrated in the gastric 19,31 epithelium of rats with acetic-acid induced ulcers treated with sangre de grado sap. C​ rofelemer, a ​ purified constituent of Sangre de Grado, has been approved by the FDA for symptomatic relief of 37,38 noninfectious diarrhea in patients with HIV/AIDS who are receiving antiretroviral therapy. C​ linical ​ studies have been conducted in acute infectious diarrhea, diarrhea in patients with HIV, and diarrhea-predominant irritable bowel syndrome (IBS).27,36,37 ​ Immunomodulating effects. In vitro research shows that Sangre de Grado acts as an ​ immunomodulator (a substance that stimulates or suppresses the immune system to help the body fight infection or other disease) by inhibiting both classical and alternative complementary pathways which inhibit the proliferation of activated T cells.33 ​ Wound-healing effects. The wound-healing effects of Sangre de Grado may be due to a variety of ​ factors. These include the antimicrobial, anti-inflammatory, and protein-binding properties of polyphenol constituents; the antioxidant properties of procyanidin constituents; and the ability of the sap to cover 19 the wound, preventing infection from surface microbes. ​ With respect to specific constituents, the ​ alkaloid taspine and the lignan dimethylcedrusine appear to play a role in wound healing.34,19,35 ​ CANNABIDIOL (CBD) Cannabis is one of the first plants to have been used as a medicine and for religious ceremonies, the 43 first accounts of its use for these purposes stretching back 5000 years. ​ Cannabis contains over 400 ​ 39 different chemicals, known as cannabinoids, making it a complex plant. ​ The chemical that leads to the ​ psychoactive “high” associated with cannabis, delta-9-tetrahydrocannabinol (THC), is only one of over 40 400 found in the plant. ​ While THC can be controversial due to its psychoactive properties, research is ​ beginning to show therapeutic potential with cannabidiol (CBD). Cannabidiol makes up around 40% of 40 cannabis extracts, and unlike THC, does not cause a psychoactive high. ​ According to the World ​ ​ Health Organization, CBD exhibits no effects indicative of any abuse or dependence potential in 41 humans. ​ As of June 2018, the only legal form of CBD that is FDA approved is Epidiolex, a ​ 42 prescription medication used to treat certain seizure disorders. ​ There is also evidence that CBD may ​ ​ be a useful treatment for a number of other medical conditions. However, this research is considerably less advanced than for treatment of epilepsy. For most indications, there is only pre-clinical evidence, while for some there is a combination of pre-clinical and limited clinical evidence. The range of conditions for which CBD has been assessed is diverse, consistent with its antioxidant, ​ anti-inflammatory, anticonvulsant, and neuroprotective qualities.54-56 ​ Clinical Efficacy and Research Related to Cannibidiol Antiepileptic effects: The clinical use of CBD is most advanced in the treatment of epilepsy. In clinical ​ trials, CBD has been demonstrated as an effective treatment for at least some forms of epilepsy, with one pure CBD product (Epidiolex®). The use of CBD for this purpose is based on a number of studies 41,46 in animals dating back to the 1970s. ​ These studies demonstrated the anti-seizure activity of ​ 47,48 cannabidiol in a number of animal models. ​ Based on this research, cannabidiol has been tested in ​ patients with epilepsy and a variety of syndromes, including Dravet, Lennox-Gastaut, Sturge-Weber, and tuberous sclerosis complex.49-53 ​ Anti-inflammatory effects:
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