Supporting Information Lun et al. 10.1073/pnas.1502599112

Table S1. Gene mutations found in some human cancers

Mutated genes Function Refs.

Acute myeloid leukemia SMC3 Structural maintenance of chromosomes 3 (14) SMC1A Structural maintenance of chromosomes 1A (14) STAG2 Stromal antigen 2 (14) RAD21 RAD21 homolog (14) FLT3 Fms-related tyrosine kinase 3 (68) NPM1 Nucleophosmin (nucleolar phosphoprotein B23 (68) DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha (68) IDH1 Isocitrate dehydrogenase 1 (68) IDH2 Isocitrate dehydrogenase 2 (68) TET2 Tet methylcytosine dioxygenase 2 (68) RUNX1 Runt-related transcription factor 1 (68) TP53 Tumor protein p53 (68) NRAS Neuroblastoma RAS viral (v-ras) oncogene homolog (68) CEBPA CCAAT/enhancer binding protein (68) WT1 Wilms tumor 1 (68) PTPN11 Protein tyrosine phosphatase (68) KIT V-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog (68) U2AF1 U2 small nuclear RNA auxiliary factor 1 (68)

KRAS V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (68) SMC1A Structural maintenance of chromosomes 1A (68) PHF6 PHD finger protein 6 (68) STAG2 Stromal antigen 2 (68) FAM5C Family with sequence similarity 5 (68) EZH2 Enhancer of zeste homolog 2 (68) HNRNPK Heterogeneous nuclear ribonucleoprotein K (68) Breast cancer TP53 Tumor protein p53 (69) PIK3CA Phosphatidylinositol-4 (69) RB1 Retinoblastoma 1 (69) PTEN Phosphatase and tensin homolog (69) MAP3K1 Mitogen-activated protein kinase kinase kinase 1 (70) CDKN1B Cyclin-dependent kinase inhibitor 1B (70) TBX3 T-box 3 (70) RUNX1 Runt-related transcription factor 1 (70) LDLRAP1 Low density lipoprotein receptor adaptor protein 1 (70) STMN2 Stathmin-like 2 (70) MYH9 Myosin (70) AGTR2 Angiotensin II receptor (70) STMN2 Stathmin-like 2 (70) SF3B1 Splicing factor 3b (70) CBFB Core-binding factor (70) AKT2 V-akt murine thymoma viral oncogene homolog 2 (71) ARID1B AT rich interactive domain 1B (SWI1-like) (71) CASP8 Caspase 8 (71) CDKN1B Cyclin-dependent kinase inhibitor 1B (71) MAP3K13 Mitogen-activated protein kinase kinase kinase 13 (71) NCOR1 Nuclear receptor corepressor 1 (71) SMARCD1 SWI/SNF related (71) GATA3 GATA binding protein 3 (12) MAP2K4 Mitogen-activated protein kinase kinase 4 (12) Prostate cancer SPOP Speckle-type POZ protein (12) FOXA1 Forkhead box A1 (12) MED12 Mediator complex subunit 12 (12) CHD1 Chromodomain helicase DNA binding protein 1 (73)

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