White matter diseases

Leukoencephalopathy Leukoaraiosis Leukodystrophy Leukomalacia

SSPE: Subacute sclerosing panencephalitis

PML: Progressive multifocal leukoencephalopathy CJD: Creutzfeldt Jacob disease

COPD: Chronic obstructive pulmonary disease

PRES: Posterior reversible encephalopathy syndrome DPHL: Delayed post-hypoxic leukoencephalopathy PVL: Periventricular leukomalacia

PCNSL: Primary CNS Lymphoma

CIVL: Chronic Ischemic vascular leukoencephalopathy CAA: Cerebral amyloid angiopathy MLD: Metachromatic leukodystrophy

LBSL: Leukoencephalopathy with brain stem and spinal cord involvement and lactate elevation

LTBL: Leukoencephalopathy with thalamus and brainstem involvement

Leukoencephalopathy

Acute Chronic

Paraneoplastic/n vascular Inflammatory Infectious Metabolic Hypoxic Toxic eoplastic

Rasmussen Paraneoplastic Uremic Moya moya CIVL Neurosyphilis Glioblastoma PCNSL DPHL Heroin encephalitis encephalitis encephalitis

Hashimoto's Primary Secondary SSPE Hodgkins encephalitis

Down's CLIPPERS PML syndrome

Sickle cell Neurosarcoidosi CJD disease s

Robinow Multiple syndrome sclerosis

Neurofibromato sis 1

Alagille syndrome

Seckle Sx

PHACE Sx

MOPD Sx

Cranial irradiation

Leukoaraiosis

Vascular Non-vascular

Small vessel disease Smoking

Type 4: Type 1: Type 3: Inherited Type 5: Venous Type 2: CAA Inflammatory Type 6: Others COPD arteriosclerosis vasculitis collagenosis vasculitis

CADASIL Susac syndrome Post radiation OSA

MELAS Neurolupus Post infectious Migraine

Sjogrens CKD

PCNSA Carotid stenosis

Hyperlipidemia

Leukodystrophy

Adult onset Childhood onset Leukodystrophy

Parieto-occipital Periventricular Brainstem Cerebellar Frontal pattern Subcortical pattern Lysosomal Peroxisomal Mitochondrial Intermediary pattern pattern invovlement involvement

X linked X linked L-2 hydroxyglutaric Cerebrotendinous Adrenoleukodystroph adrenoleukodystroph adrenoleukodystroph Krabbe disease Alexander disease Krabbe's disease LBSL Canavan's disease aciduria xanthomatosis y y y

Adult onset Metachromatic Metachromatic Polyglucosan body autosomal dominant Alexander disease MLD Refsum's LTBL Krabbe disease leukodystrophy leukodystrophy disease leukodystrophy

Leukoencephalopathy Leukoencephalopathy Leukoencephalopathy Leukoencephalopathy with brainstem and with brainstem and with brainstem and with axonal spheroids Salla's disease Zellweger's spinal cord spinal cord spinal cord and pigmented glia involvement involvement involvement

Adult onset Sjogren- Larsson autosomal dominant Fucosidosis syndrome leukodystrophy

FXTAS

L-2 hydroxyglutaric aciduria

Leukomalacia

Neonatal Adult

Periventricular leukomalacia Post ischemic leukomalacia