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Food and Drug Administration, HHS Pt. 582

MeV, except as permitted by Subpart B—General Purpose Food § 179.26(a)(4) of this chapter; or Additives (4) X-rays generated from machine 582.1005 . sources using tantalum or gold as the 582.1009 Adipic acid. target material and using energies not 582.1033 Citric acid. to exceed 7.5 MeV. 582.1057 Hydrochloric acid. (b) Limitation. The ionizing radiation 582.1061 Lactic acid. is used for feed or feed ingredients that 582.1069 Malic acid. do not contain drugs. 582.1073 Phosphoric acid. 582.1077 Potassium acid tartrate. (c) Use. Ionizing radiation is used as 582.1087 Sodium acid pyrophosphate. a single treatment for rendering com- 582.1091 Succinic acid. plete poultry diets or poultry feed in- 582.1095 Sulfuric acid. gredients salmonella negative as fol- 582.1099 Tartaric acid. lows: 582.1125 Aluminum sulfate. (1) Minimum dose 2.0 kiloGrays (kGy) 582.1127 Aluminum ammonium sulfate. (0.2 megarad (Mrad)); maximum dose 25 582.1129 Aluminum potassium sulfate. 582.1131 Aluminum sodium sulfate. kGy (2.5 megarads Mrad). The absorbed 582.1135 Ammonium bicarbonate. dose of irradiation is to be based on ini- 582.1137 Ammonium carbonate. tial concentration of salmonella using 582.1139 Ammonium hydroxide. the relationship that 1.0 kGy (0.1 Mrad) 582.1141 Ammonium phosphate. reduces salmonella concentration by 582.1143 Ammonium sulfate. one log cycle (one decimal reduction). 582.1155 Bentonite. 582.1165 Butane. (2) Feeds treated by irradiation 582.1191 carbonate. should be formulated to account for 582.1193 Calcium chloride. nutritional loss. 582.1195 Calcium citrate. (3) If an irradiated feed ingredient is 582.1199 Calcium gluconate. less than 5 percent of the final product, 582.1205 Calcium hydroxide. the final product can be irradiated 582.1207 Calcium lactate. without being considered to be re- 582.1210 Calcium oxide. 582.1217 Calcium phosphate. irradiated. 582.1235 Caramel. [60 FR 50099, Sept. 28, 1995, as amended at 78 582.1240 Carbon dioxide. FR 27304, May 10, 2013; 78 FR 34565, June 10, 582.1275 Dextrans. 2013] 582.1320 Glycerin. 582.1324 Glyceryl monostearate. 582.1355 Helium. PART 582—SUBSTANCES 582.1366 . GENERALLY RECOGNIZED AS SAFE 582.1400 . 582.1425 carbonate. 582.1428 Magnesium hydroxide. Subpart A—General Provisions 582.1431 Magnesium oxide. Sec. 582.1480 Methylcellulose. 582.1 Substances that are generally recog- 582.1500 Monoammonium glutamate. nized as safe. 582.1516 Monopotassium glutamate. 582.1540 Nitrogen. 582.10 and other natural 582.1585 Papain. and flavorings. 582.1613 Potassium bicarbonate. 582.20 Essential oils, (solvent- 582.1619 Potassium carbonate. free), and natural extractives (including 582.1625 Potassium citrate. distillates). 582.1631 Potassium hydroxide. 582.30 Natural substances used in conjunc- 582.1643 Potassium sulfate. tion with spices and other natural 582.1655 Propane. seasonings and flavorings. 582.1666 Propylene glycol. 582.40 Natural extractives (solvent-free) 582.1685 Rennet. used in conjunction with spices, 582.1711 Silica aerogel. seasonings, and flavorings. 582.1721 Sodium acetate. 582.50 Certain other spices, seasonings, es- 582.1736 Sodium bicarbonate. sential oils, oleoresins, and natural ex- 582.1742 Sodium carbonate. tracts. 582.1745 Sodium carboxymethylcellulose. 582.60 Synthetic flavoring substances and 582.1748 Sodium caseinate. adjuvants. 582.1751 Sodium citrate. 582.80 Trace minerals added to animal feeds. 582.1763 Sodium hydroxide. 582.99 Adjuvants for pesticide chemicals. 582.1775 Sodium pectinate.

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582.1778 Sodium phosphate. Subpart F—Nutrients and/or Dietary 582.1781 Sodium aluminum phosphate. Supplements 582.1792 Sodium sesquicarbonate. 582.1804 Sodium potassium tartrate. 582.5013 Ascorbic acid. 582.1810 Sodium tripolyphosphate. 582.5017 Aspartic acid. 582.1901 Triacetin. 582.5049 Aminoacetic acid. 582.1973 Beeswax. 582.5065 Linoleic acid. 582.5118 Alanine. 582.1975 Bleached beeswax. 582.5145 Arginine. 582.1978 Carnauba . 582.5159 Biotin. 582.5191 Calcium carbonate. Subpart C—Anticaking Agents 582.5195 Calcium citrate. 582.5201 Calcium glycerophosphate. 582.2122 Aluminum calcium silicate. 582.5210 Calcium oxide. 582.2227 Calcium silicate. 582.5212 Calcium pantothenate. 582.2437 Magnesium silicate. 582.5217 Calcium phosphate. 582.2727 Sodium aluminosilicate. 582.5223 Calcium pyrophosphate. 582.2729 Hydrated sodium calcium 582.5230 Calcium sulfate. aluminosilicate. 582.5245 Carotene. 582.2906 Tricalcium silicate. 582.5250 bitartrate. 582.5252 Choline chloride. Subpart D—Chemical Preservatives 582.5260 Copper gluconate. 582.5271 Cysteine. 582.3013 Ascorbic acid. 582.5273 Cystine. 582.3021 Benzoic acid. 582.5301 Ferric phosphate. 582.3041 Erythorbic acid. 582.5304 Ferric pyrophosphate. 582.3081 Propionic acid. 582.5306 Ferric sodium pyrophosphate. 582.3089 Sorbic acid. 582.5308 Ferrous gluconate. 582.3109 Thiodipropionic acid. 582.5311 Ferrous lactate. 582.3149 Ascorbyl palmitate. 582.5315 Ferrous sulfate. 582.3169 Butylated hydroxyanisole. 582.5361 Histidine. 582.3173 Butylated hydroxytoluene. 582.5370 Inositol. 582.5375 reduced. 582.3189 Calcium ascorbate. 582.5381 Isoleucine. 582.3221 Calcium propionate. 582.5406 Leucine. 582.3225 Calcium sorbate. 582.5411 Lysine. 582.3280 Dilauryl thiodipropionate. 582.5431 Magnesium oxide. 582.3336 Gum guaiac. 582.5434 Magnesium phosphate. 582.3490 Methylparaben. 582.5443 Magnesium sulfate. 582.3616 Potassium bisulfite. 582.5446 chloride. 582.3637 Potassium metabisulfite. 582.5449 Manganese citrate. 582.3640 Potassium sorbate. 582.5452 Manganese gluconate. 582.3660 Propyl gallate. 582.5455 Manganese glycerophosphate. 582.3670 Propylparaben. 582.5458 Manganese hypophosphite. 582.3731 Sodium ascorbate. 582.5461 Manganese sulfate. 582.3733 Sodium benzoate. 582.5464 Manganous oxide. 582.5470 Mannitol. 582.3739 Sodium bisulfite. 582.5475 Methionine. 582.3766 Sodium metabisulfite. 582.5477 Methionine hydroxy analog and its 582.3784 Sodium propionate. calcium . 582.3795 Sodium sorbate. 582.5530 . 582.3798 Sodium sulfite. 582.5535 Niacinamide. 582.3845 Stannous chloride. 582.5580 D-Pantothenyl alcohol. 582.3862 Sulfur dioxide. 582.5590 Phenylalanine. 582.3890 Tocopherols. 582.5622 Potassium chloride. 582.5628 Potassium glycerophosphate. Subpart E—Emulsifying Agents 582.5634 Potassium iodide. 582.5650 Proline. 582.4101 Diacetyl tartaric acid esters of 582.5676 Pyridoxine hydrochloride. mono- and of edible or 582.5695 Riboflavin. oils, or edible -forming fatty acids. 582.5697 Riboflavin-5-phosphate. 582.4505 Mono- and diglycerides of edible 582.5701 Serine. fats or oils, or edible fat-forming acids. 582.5772 Sodium pantothenate. 582.4521 Monosodium phosphate derivatives 582.5778 Sodium phosphate. of mono- and diglycerides of edible fats 582.5835 Sorbitol. or oils, or edible fat-forming fatty acids. 582.5875 hydrochloride. 582.4666 Propylene glycol. 582.5878 Thiamine mononitrate.

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582.5881 Threonine. Subpart A—General Provisions 582.5890 Tocopherols. 582.5892 a-Tocopherol acetate. § 582.1 Substances that are generally 582.5915 Tryptophane. recognized as safe. 582.5920 Tyrosine. 582.5925 Valine. (a) It is impracticable to list all sub- 582.5930 A. stances that are generally recognized 582.5933 acetate. as safe for their intended use. However, 582.5936 Vitamin A palmitate. by way of illustration, the Commis- 582.5945 Vitamin B12. sioner regards such common food in- 582.5950 Vitamin D . 2 gredients as , pepper, , vin- 582.5953 Vitamin D3. 582.5985 chloride. egar, powder, and monosodium 582.5988 Zinc gluconate. glutamate as safe for their intended 582.5991 Zinc oxide. use. The lists in subparts B through H 582.5994 Zinc stearate. of this part include additional sub- 582.5997 Zinc sulfate. stances that, when used for the pur- Subpart G—Sequestrants poses indicated, in accordance with good manufacturing or feeding prac- 582.6033 Citric acid. tice, are regarded by the Commissioner 582.6085 Sodium acid phosphate. as generally recognized as safe for such 582.6099 Tartaric acid. uses. 582.6185 Calcium acetate. 582.6193 Calcium chloride. (b) For the purposes of this section, 582.6195 Calcium citrate. good manufacturing or feeding practice 582.6197 Calcium diacetate. shall be defined to include the fol- 582.6199 Calcium gluconate. lowing restrictions: 582.6203 Calcium hexametaphosphate. (1) The quantity of a substance added 582.6215 Monobasic calcium phosphate. to animal food does not exceed the 582.6219 Calcium phytate. amount reasonably required to accom- 582.6285 Dipotassium phosphate. 582.6290 Disodium phosphate. plish its intended physical, nutritional, 582.6386 Isopropyl citrate. or other technical effect in food; and 582.6511 Monoisopropyl citrate. (2) The quantity of a substance that 582.6625 Potassium citrate. becomes a component of animal food as 582.6751 Sodium citrate. a result of its use in the manufac- 582.6754 Sodium diacetate. turing, processing, or packaging of 582.6757 Sodium gluconate. food, and which is not intended to ac- 582.6760 Sodium hexametaphosphate. complish any physical or other tech- 582.6769 Sodium metaphosphate. 582.6778 Sodium phosphate. nical effect in the food itself, shall be 582.6787 Sodium pyrophosphate. reduced to the extent reasonably pos- 582.6789 Tetra sodium pyrophosphate. sible. 582.6801 Sodium tartrate. (3) The substance is of appropriate 582.6804 Sodium potassium tartrate. grade and is prepared and handled as a 582.6807 Sodium thiosulfate. food ingredient. Upon request the Com- 582.6810 Sodium tripolyphosphate. missioner will offer an opinion, based 582.6851 Stearyl citrate. on specifications and intended use, as Subpart H—Stabilizers to whether or not a particular grade or lot of the substance is of suitable pu- 582.7115 Agar-agar. rity for use in food and would generally 582.7133 Ammonium alginate. be regarded as safe for the purpose in- 582.7187 Calcium alginate. 582.7255 Chondrus . tended, by experts qualified to evaluate 582.7330 . its safety. 582.7333 Gum ghatti. (c) The inclusion of substances in the 582.7339 Guar gum. list of nutrients does not constitute a 582.7343 Locust gum. finding on the part of the Department 582.7349 Sterculia gum. that the substance is useful as a sup- 582.7351 Gum tragacanth. plement to the diet for animals. 582.7610 Potassium alginate. (d) Substances that are generally rec- 582.7724 Sodium alginate. ognized as safe for their intended use AUTHORITY: 21 U.S.C. 321, 342, 348, 371. within the meaning of section 409 of SOURCE: 41 FR 38657, Sept. 10, 1976, unless the Act are listed in subparts B otherwise noted. through H of this part. When the status

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of a substance has been reevaluated will not affect its status for other uses and affirmed as GRAS or deleted from not specified in the referenced regula- subparts B through H of this part, an tion, pending a specific review of such appropriate explanation will be noted, other uses. e.g., ‘‘affirmed as GRAS,’’ ‘‘food addi- tive regulation,’’ ‘‘interim food addi- § 582.10 Spices and other natural tive regulation,’’ or ‘‘prohibited from seasonings and flavorings. use in food,’’ with a reference to the Spices and other natural seasonings appropriate new regulation. Such nota- and flavorings that are generally rec- tion will apply only to the specific use ognized as safe for their intended use, covered by the review, e.g., direct ani- mal food use and/or indirect animal within the meaning of section 409 of food use and/or animal feed use and the act, are as follows:

Common name of source

Alfalfa and ...... Medicago sativa L. ...... Pimenta Lindl. Ambrette seed ...... Hibiscus abelmoschus L. Angelica ...... L. or other spp. of Angelica. Angelica root ...... Do. Angelica seed ...... Do. Angostura (cusparia bark) ...... Galipea officinalis Hancock. ...... Pimpinella anisum L. Anise, star ...... verum Hook. f. Balm () ...... Melissa officinalis L. , bush ...... Ocimum minimum L. Basil, sweet ...... Ocimum basilicum L. Bay ...... nobilis L. Calendula ...... L. Camomile (), English or Roman ...... Anthemis nobilis L. Camomile (chamomile), German or Hungarian ...... Matricaria chamomilla L. Capers ...... Capparis spinosa L. ...... Capsicum frutescens L. or Capsicum annuum L. ...... Carum carvi L. Caraway, black (black ) ...... L. (cardamon) ...... Elettaria cardamomum Maton. Cassia, Chinese ...... cassia Blume. Cassia, Padang or Batavia ...... Cinnamomum burmanni Blume. Cassia, Saigon ...... Cinnamomum loureirii Nees. ...... Capsicum frutescens L. or Capsicum annuum L. seed ...... Apium graveolens L. ...... Anthriscus cerefolium (L.) Hoffm. ...... Allium schoenoprasum L. , Ceylon ...... Cinnamomum zeylanicum Nees. Cinnamon, Chinese ...... Blume. Cinnamon, Saigon ...... Cinnamomum loureirii Nees. Clary (clary sage) ...... sclarea L. Clover ...... Trifolium spp. ...... Eugenia caryophyllata Thunb. ...... Coriandrum sativum L. Cumin (cummin) ...... Cuminum cyminum L. Cumin, black (black caraway) ...... Nigella sativa L. ...... Anethum graveolens L. Elder ...... Sambucus canadensis L. , common ...... Foeniculum vulgare Mill. Fennel, sweet (finocchio, Florence fennel) ...... Foeniculum vulgare Mill. var. duice (DC.) Alex. ...... Trigonella foenum-graecum L. Galanga () ...... Alpina officinarum Hance. ...... Allium sativum L. Geranium ...... Pelargonium spp. ...... Zingiber officinale Rosc. Glycyrrhiza ...... Glycyrrhiza glabra L. and other spp. of Glycyrrhiza. of paradise ...... Amomum melegueta Rosc. Horehound (hoarhound) ...... Marrubium vulgare L. ...... Armoracia lapathifolia Gilib. Hyssop ...... L. Lavender ...... Lavandula officinalis Chaix. Licorice ...... Glycyrrhiza glabra L. and other spp. of Glycyrrhiza. Linden flowers ...... Tilia spp. ...... Myristica fragrans Houtt. Marigold, pot ...... Calendula officinalis L. , pot ...... Majorana onites (L.) Benth.

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Common name Botanical name of plant source

Marjoram, sweet ...... Majorana hortensis Moench. , black or brown ...... nigra (L.) Koch. Mustard, brown ...... (L.) Coss. Mustard, white or yellow ...... Brassica hirta Moench. ...... Myristica fragrans Houtt. (oreganum, Mexican oregano, Mexican sage, origan) Lippia spp. ...... Capsicum annuum L. ...... Petroselinum crispum (Mill.) Mansf. Pepper, black ...... Piper nigrum L. Pepper, cayenne ...... Capsicum frutescens L. or Capsicum annuum L. Pepper, red ...... Do. Pepper, white ...... Piper nigrum L. ...... piperita L. seed ...... somniferum L. Pot marigold ...... Calendula officinalis L. Pot marjoram ...... Majorana onites (L.) Benth. ...... Rosmarinus officinalis L. Rue ...... L. ...... Crocus sativus L. Sage ...... L. Sage, Greek ...... Salvia triloba L. Savory, summer ...... Satureia hortensis L. (). Savory, winter ...... Satureia montana L. (Satureja). ...... Sesamum indicum L. ...... Mentha spicata L. Star anise ...... Hook. f. ...... dracunculus L. ...... L. Thyme, wild or creeping ...... Thymus serpyllum L. ...... longa L. ...... Andr. or J. W. Moore. Zedoary ...... Rosc.

§ 582.20 Essential oils, oleoresins (sol- ing distillates) that are generally rec- vent-free), and natural extractives ognized as safe for their intended use, (including distillates). within the meaning of section 409 of Essential oils, oleoresins (solvent- the act, are as follows: free), and natural extractives (includ-

Common name Botanical name of plant source

Alfalfa ...... Medicago sativa L. Allspice ...... Pimenta officinalis Lindl. Almond, bitter (free from prussic acid) ...... Prunus amygdalus Batsch, Prunus armeniaca L. or Prunus persica (L.) Batsch. Ambrette (seed) ...... Hibiscus moschatus Moench. Angelica root ...... Angelica archangelica L. Angelica seed ...... Do. Angelica stem ...... Do. Angostura (cusparia bark) ...... Galipea officinalis Hancock. Anise ...... Pimpinella anisum L. Asafetida ...... Ferula assa-foetida L. and related spp. of Ferula. Balm (lemon balm) ...... Melissa officinalis L. Balsam of ...... Myroxylon pereirae Klotzsch. Basil ...... Ocimum basilicum L. Bay ...... L. Bay (myrcia oil) ...... Pimenta racemosa (Mill.) J. W. Moore. Bergamot (bergamot orange) ...... Citrus aurantium L. subsp. bergamia Wright et Arn. Bitter almond (free from prussic acid) ...... Prunus amygdalus Batsch, Prunus armeniaca L., or Prunus persica (L.) Batsch. Bois de rose ...... Aniba rosaeodora Ducke. Cacao ...... L. Camomile (chamomile) flowers, Hungarian ...... Matricaria chamomilla L. Camomile (chamomile) flowers, Roman or English ...... Anthemis nobilis L. Cananga ...... Cananga odorata Hook. f. and Thoms. Capsicum ...... Capsicum frutescens L. and Capsicum annuum L. Caraway ...... Carum carvi L. Cardamom seed (cardamon) ...... Elettaria cardamomum Maton. Carob bean ...... Ceratonia siliqua L. ...... Daucus carota L.

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Common name Botanical name of plant source

Cascarilla bark ...... Croton eluteria Benn. Cassia bark, Chinese ...... Cinnamomum cassia Blume. Cassia bark, Padang or Batavia ...... Cinnamomum burmanni Blume. Cassia bark, Saigon ...... Cinnamomum loureirii Nees. Celery seed ...... Apium graveolens L. Cherry, wild, bark ...... Prunus serotina Ehrh. Chervil ...... Anthriscus cerefolium (L.) Hoffm. Chicory ...... Cichorium intybus L. Cinnamon bark, Ceylon ...... Cinnamomum zeylanicum Nees. Cinnamon bark, Chinese ...... Cinnamomum cassia Blume. Cinnamon bark, Saigon ...... Cinnamomum loureirii Nees. Cinnamon , Ceylon ...... Cinnamomum zeylanicum Nees. Cinnamon leaf, Chinese ...... Cinnamomum cassia Blume. Cinnamon leaf, Saigon ...... Cinnamomum loureirii Nees. Citronella ...... nardus Rendle. Citrus peels ...... Citrus spp. Clary (clary sage) ...... Salvia sclarea L. bud ...... Eugenia caryophyllata Thunb. Clove leaf ...... Do. Clove stem ...... Do. Clover ...... Trifolium spp. Coca (decocainized) ...... Erythroxylum coca Lam. and other spp. of Erythroxylum. ...... Coffea spp. ...... Cola acuminata Schott and Endl., and other spp. of Cola. Coriander ...... Coriandrum sativum L. Corn silk ...... Zea mays L. Cumin (cummin) ...... Cuminum cyminum L. Curacao orange peel (orange, bitter peel) ...... Citrus aurantium L. Cusparia bark ...... Galipea officinalis Hancock. Dandelion ...... Taraxacum officinale Weber and T. laevigatum DC. Dandelion root ...... Do. Dill ...... Anethum graveolens L. Dog grass (quackgrass, triticum) ...... Agropyron repens (L.) Beauv. Elder flowers ...... Sambucus canadensis L. and S. nigra L. Estragole (esdragol, esdragon, tarragon) ...... Artemisia dracunculus L. Estragon (tarragon) ...... Do. Fennel, sweet ...... Foeniculum vulgare Mill. Fenugreek ...... Trigonella foenum-graecum L. Galanga (galangal) ...... Hance. Garlic ...... Allium sativum L. Geranium ...... Pelargonium spp. Geranium, East Indian ...... Cymbopogon martini Stapf. Geranium, rose ...... Pelargonium graveolens L’Her. Ginger ...... Zingiber officinale Rosc. Glycyrrhiza ...... Glycyrrhiza glabra L. and other spp. of Glycyrrhiza. Glycyrrhizin, ammoniated ...... Do. Grapefruit ...... Citrus paradisi Macf. Guava ...... Psidium spp. Hickory bark ...... Carya spp. Horehound (hoarhound) ...... Marrubium vulgare L. Hops ...... Humulus lupulus L. Horsemint ...... Monarda punctata L. Hyssop ...... Hyssopus officinalis L. Immortelle ...... Helichrysum augustifolium DC. Jasmine ...... Jaminum officinale L. and other spp. of Jasminum. Juniper () ...... Juniperus communis L. Kola nut ...... Cola acuminata Schott and Endl., and other spp. of Cola. Laurel berries ...... Laurus nobilis L. Laurel leaves ...... Laurus spp. Lavender ...... Lavandula officinalis Chaix. Lavender, spike ...... Lavandula latifolia Vill. Lavandin ...... Hybrids between Lavandula officinalis Chaix and Lavandula latifolin Vill. Lemon ...... Citrus limon (L.) Burm. f. Lemon balm (see balm). Lemon grass ...... Cymbopogon citratus DC. and Cymbopogon flexuosus Stapf. Lemon peel ...... Citrus limon (L.) Burm. f. Licorice ...... Glycyrrhiza glabra L. and other spp. of Glycyrrhiza. Lime ...... Citrus aurantifolia Swingle. Linden flowers ...... Tilia spp. Locust bean ...... Ceratonia siliqua L. Lupulin ...... Humulus lupulus L. Mace ...... Myristica fragrans Houtt. Malt (extract) ...... Hordeum vulgare L., or other grains.

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Common name Botanical name of plant source

Mandarin ...... Citrus reticulata Blanco. Marjoram, sweet ...... Majorana hortensis Moench. Mate 1 ...... Ilex paraguariensis St. Hil. Melissa (see balm). ...... Mentha spp. Menthyl acetate ...... Do. Molasses (extract) ...... Saccharum officinarum L. Mustard ...... Brassica spp. Naringin ...... Citrus paradisi Macf. Neroli, bigarade ...... Citrus aurantium L. Nutmeg ...... Myristica fragrans Houtt. ...... Allium cepa L. Orange, bitter, flowers ...... Citrus aurantium L. Orange, bitter, peel ...... Do. Orange leaf ...... Citrus sinensis (L.) Osbeck. Orange, sweet ...... Do. Orange, sweet, flowers ...... Do. Orange, sweet, peel ...... Do. Origanum ...... Origanum spp. Palmarosa ...... Cymbopogon martini Stapf. Paprika ...... Capsicum annuum L. Parsley ...... Petroselinum crispum (Mill.) Mansf. Pepper, black ...... Piper nigrum L. Pepper, white ...... Piper nigrum L. Peppermint ...... Mentha piperita L. Peruvian balsam ...... Myroxylon pereirae Klotzsch. Petitgrain ...... Citrus aurantium L. Petitgrain lemon ...... Citrus limon (L.) Burm. f. Petitgrain mandarin or tangerine ...... Citrus reticulata Blanco. Pimenta ...... Pimenta officinalis Lindl. Pimenta leaf ...... Primenta officinalis Lindl. Pipsissewa leaves ...... Chimaphila umbellata Nutt. ...... Punica granatum L. Prickly ash bark ...... Xanthoxylum (or Zanthoxylum) Americanum Mill. or Xanthoxylum clava-herculis L. Rose absolute ...... Rosa alba L., Rosa centifolia L., Rosa damascena Mill., Rosa gallica L., and vars. of these spp. Rose (otto of roses, attar of roses) ...... Do. Rose buds ...... Do. Rose flowers ...... Do. Rose (hips) ...... Do. Rose geranium ...... Pelargonium graveolens L’Her. Rose leaves ...... Rosa spp. Rosemary ...... Rosmarinus officinalis L. Rue ...... Ruta graveolens L. Saffron ...... Crocus sativus L. Sage ...... Salvia officinalis L. Sage, Greek ...... Salvia triloba L. Sage, Spanish ...... Salvia lavandulaefolia Vahl. St. John’s ...... Ceratonia siliqua L. Savory, summer ...... Satureia hortensis L. Savory, winter ...... Satureia montana L. molle ...... L. Sloe berries (blackthorn berries) ...... Prunus spinosa L. Spearmint ...... Mentha spicata L. Spike lavender ...... Lavandula latifolia Vill. ...... Tamarindus indica L. Tangerine ...... Citrus reticulata Blanco. Tannic acid ...... Nutgalls of Quercus infectoria Oliver and related spp. of Quercus. Also in many other . Tarragon ...... Artemisia dracunculus L. ...... Thea sinensis L. Thyme ...... Thymus vulgaris L. and Thymus zygis var. gracilis Boiss. Thyme, white ...... Do. Thyme, wild or creeping ...... Thymus serpyllum L. Triticum (see dog grass). Tuberose ...... Polianthes tuberosa L. Turmeric ...... Curcuma longa L. Vanilla ...... Vanilla planifolia Andr. or Vanilla tahitensis J. W. Moore. Violet flowers ...... Viola odorata L. Violet leaves ...... Do. Violet leaves absolute ...... Do. Wild cherry bark ...... Prunus serotina Ehrh. Ylang-ylang ...... Cananga odorata Hook. f. and Thoms.

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Common name Botanical name of plant source

Zedoary bark ...... Curcuma zedoaria Rosc.

§ 582.30 Natural substances used in seasonings and flavorings that are gen- conjunction with spices and other erally recognized as safe for their in- natural seasonings and flavorings. tended use, within the meaning of sec- Natural substances used in conjunc- tion 409 of the act, are as follows: tion with spices and other natural

Common name Botanical name of plant source

Algae, brown (kelp) ...... Laminaria spp. and Nereocystis spp. Algae, red ...... Porphyra spp. and Rhodymenia palmata (L.) Grev. Dulse ...... Rhodymenia palmata (L.)

§ 582.40 Natural extractives (solvent- seasonings, and flavorings that are free) used in conjunction with generally recognized as safe for their spices, seasonings, and flavorings. intended use, within the meaning of Natural extractives (solvent-free) section 409 of the act, are as follows: used in conjunction with spices,

Common name Botanical name of plant source

Algae, brown ...... Laminaria spp. and Nereocystis spp. Algae, red ...... Porphyra spp. and Rhodymenia palmata (L.) Grev. Apricot kernel (persic oil) ...... Prunus armeniaca L. Dulse ...... Rhodymenia palmata (L.) Grev. Kelp (see algae, brown). Peach kernel (persic oil) ...... Prunus persica Sieb. et Zucc. Peanut stearine ...... Arachis hypogaea L. Persic oil (see apricot kernel and peach kernel). Quince seed ...... Cydonia oblonga Miller.

§ 582.50 Certain other spices, tracts that are generally recognized as seasonings, essential oils, safe for their intended use, within the oleoresins, and natural . meaning of section 409 of the act, are Certain other spices, seasonings, es- as follows: sential oils, oleoresins, and natural ex-

Common name Derivation

Ambergris ...... Physeter macrocephalus L. ...... Castor fiber L. and C. canadensis Kuhl. Civet (zibeth, zibet, zibetum) ...... Civet cats, Viverra civetta Schreber and Viverra zibetha Schreber. Cognac oil, white and green ...... Ethyl oenanthate, so-called. Musk (Tonquin musk) ...... Musk deer, Moschus moschiferus L.

§ 582.60 Synthetic flavoring substances Aconitic acid (equisetic acid, citridic acid, and adjuvants. achilleic acid). (parapropenyl anisole). Synthetic flavoring substances and Benzaldehyde (benzoic aldehyde). adjuvants that are generally recog- N-Butyric acid (butanoic acid). nized as safe for their intended use, d- or l-Carvone (carvol). within the meaning of section 409 of (cinnamic aldehyde). the act, are as follows: Citral (2,6-dimethyloctadien-2,6-al-8, geranial, neral). (ethanal). Acetoin (acetyl methylcarbinol).

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Decanal (N-decylaldhehyde, capraldehyde, Element Source compounds capric aldehyde, caprinaldehyde, aldehyde C-10). Reduced iron. Diacetyl (2,3-butandeione). Ethyl acetate. Manganese ...... Manganese acetate. Ethyl butyrate. Manganese carbonate. Manganese citrate (soluble). 3-Methyl-3-phenyl glycidic acid ethyl ester Manganese chloride. (ethyl-methyl-phenyl-glycidate, so-called Manganese gluconate. strawberry aldehyde, C-16 aldehyde). Manganese orthophosphate. Ethyl . Manganese phosphate (dibasic). . Manganese sulfate. (3,7-dimethyl-2,6 and 3,6-octadien-1- Manganous oxide. Zinc ...... Zinc acetate. ol). Zinc carbonate. Geranyl acetate (geraniol acetate). Zinc chloride. (glyceryl) tributyrate (tributyrin, Zinc oxide. butyrin). Zinc sulfate. (d-, l-, and dl-). (linalol, 3,7-dimethyl-1,6-octadien-3- § 582.99 Adjuvants for pesticide chemi- ol). cals. Linalyl acetate (bergamol). l-Malic acid. Adjuvants, identified and used in ac- Methyl anthranilate (methyl-2- cordance with 40 CFR 180.1001(c) and aminobenzoate). (d), which are added to pesticide use di- Piperonal (3,4-methylenedioxy-benzaldehyde, lutions by a grower or applicator prior heliotropin). to application to the raw agricultural Vanillin. commodity, are exempt from the re- § 582.80 Trace minerals added to ani- quirement of tolerances under section mal feeds. 409 of the act. These substances added to animal feeds as nutritional dietary supple- Subpart B—General Purpose Food ments are generally recognized as safe Additives when added at levels consistent with good feeding practice. 1 § 582.1005 Acetic acid. (a) Product. Acetic acid. Element Source compounds (b) Conditions of use. This substance Cobalt ...... Cobalt acetate. is generally recognized as safe when Cobalt carbonate. used in accordance with good manufac- Cobalt chloride. turing or feeding practice. Cobalt oxide. Cobalt sulfate. Copper ...... Copper carbonate. § 582.1009 Adipic acid. Copper chloride. (a) Product. Adipic acid. Copper gluconate. Copper hydroxide. (b) [Reserved] Copper orthophosphate. (c) Limitations, restrictions, or expla- Copper oxide. nation. This substance is generally rec- Copper pyrophosphate. Copper sulfate. ognized as safe when used as a buffer Iodine ...... Calcium iodate. and neutralizing agent in accordance Calcium iodobehenate. with good manufacturing or feeding Cuprous iodide. 3,5-Diiodosalicylic acid. practice. Ethylenediamine dihydroiodide. Potassium iodate. § 582.1033 Citric acid. Potassium iodide. Sodium iodate. (a) Product. Citric acid. Sodium iodide. (b) Conditions of use. This substance iodide. is generally recognized as safe when Iron ...... Iron ammonium citrate. used in accordance with good manufac- Iron carbonate. Iron chloride. turing or feeding practice. Iron gluconate. Iron oxide. § 582.1057 Hydrochloric acid. Iron phosphate. Iron pyrophosphate. (a) Product. Hydrochloric acid. Iron sulfate. (b) [Reserved] (c) Limitations, restrictions, or expla- 1 All substances listed may be in anhydrous nation. This substance is generally rec- or hydrated form. ognized as safe when used as a buffer

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and neutralizing agent in accordance used in accordance with good manufac- with good manufacturing or feeding turing or feeding practice. practice. § 582.1125 Aluminum sulfate. § 582.1061 Lactic acid. (a) Product. Aluminum sulfate. (a) Product. Lactic acid. (b) Conditions of use. This substance (b) Conditions of use. This substance is generally recognized as safe when is generally recognized as safe when used in accordance with good manufac- used in accordance with good manufac- turing or feeding practice. turing or feeding practice. § 582.1127 Aluminum ammonium sul- § 582.1069 Malic acid. fate. (a) Product. Malic acid. (a) Product. Aluminum ammonium (b) Conditions of use. This substance sulfate. is generally recognized as safe when (b) Conditions of use. This substance used in accordance with good manufac- is generally recognized as safe when turing or feeding practice. used in accordance with good manufac- § 582.1073 Phosphoric acid. turing or feeding practice. (a) Product. Phosphoric acid. § 582.1129 Aluminum potassium sul- (b) Conditions of use. This substance fate. is generally recognized as safe when used in accordance with good manufac- (a) Product. Aluminum potassium sul- turing or feeding practice. fate. (b) Conditions of use. This substance § 582.1077 Potassium acid tartrate. is generally recognized as safe when (a) Product. Potassium acid tartrate. used in accordance with good manufac- (b) Conditions of use. This substance turing or feeding practice. is generally recognized as safe when used in accordance with good manufac- § 582.1131 Aluminum sodium sulfate. turing or feeding practice. (a) Product. Aluminum sodium sul- fate. § 582.1087 Sodium acid pyrophosphate. (b) Conditions of use. This substance (a) Product. Sodium acid is generally recognized as safe when pyrophosphate. used in accordance with good manufac- (b) Conditions of use. This substance turing or feeding practice. is generally recognized as safe when used in accordance with good manufac- § 582.1135 Ammonium bicarbonate. turing or feeding practice. (a) Product. Ammonium bicarbonate. § 582.1091 Succinic acid. (b) Conditions of use. This substance is generally recognized as safe when (a) Product. Succinic acid. used in accordance with good manufac- (b) Conditions of use. This substance turing or feeding practice. is generally recognized as safe when used in accordance with good manufac- § 582.1137 Ammonium carbonate. turing or feeding practice. (a) Product. Ammonium carbonate. § 582.1095 Sulfuric acid. (b) Conditions of use. This substance (a) Product. Sulfuric acid. is generally recognized as safe when (b) Conditions of use. This substance used in accordance with good manufac- is generally recognized as safe when turing or feeding practice. used in accordance with good manufac- turing or feeding practice. § 582.1139 Ammonium hydroxide. (a) Product. Ammonium hydroxide. § 582.1099 Tartaric acid. (b) Conditions of use. This substance (a) Product. Tartaric acid. is generally recognized as safe when (b) Conditions of use. This substance used in accordance with good manufac- is generally recognized as safe when turing or feeding practice.

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§ 582.1141 Ammonium phosphate. § 582.1205 Calcium hydroxide. (a) Product. Ammonium phosphate (a) Product. Calcium hydroxide. (mono- and dibasic). (b) Conditions of use. This substance (b) Conditions of use. This substance is generally recognized as safe when is generally recognized as safe when used in accordance with good manufac- used in accordance with good manufac- turing or feeding practice. turing or feeding practice. § 582.1207 Calcium lactate. § 582.1143 Ammonium sulfate. (a) Product. Calcium lactate. (a) Product. Ammonium sulfate. (b) Conditions of use. This substance (b) Conditions of use. This substance is generally recognized as safe when is generally recognized as safe when used in accordance with good manufac- used in accordance with good manufac- turing or feeding practice. turing or feeding practice. § 582.1210 Calcium oxide. § 582.1155 Bentonite. (a) Product. Calcium oxide. (a) Product. Bentonite. (b) Conditions of use. This substance (b) Conditions of use. This substance is generally recognized as safe when is generally recognized as safe when used in accordance with good manufac- used in accordance with good manufac- turing or feeding practice. turing or feeding practice. § 582.1217 Calcium phosphate. § 582.1165 Butane. (a) Product. Calcium phosphate (a) Product. Butane. (mono-, di-, and tribasic). (b) Conditions of use. This substance (b) Conditions of use. This substance is generally recognized as safe when is generally recognized as safe when used in accordance with good manufac- used in accordance with good manufac- turing or feeding practice. turing or feeding practice. § 582.1235 Caramel. § 582.1191 Calcium carbonate. (a) Product. Caramel. (a) Product. Calcium carbonate. (b) Conditions of use. This substance (b) Conditions of use. This substance is generally recognized as safe when is generally recognized as safe when used in accordance with good manufac- used in accordance with good manufac- turing or feeding practice. turing or feeding practice. § 582.1240 Carbon dioxide. § 582.1193 Calcium chloride. (a) Product. Carbon dioxide. (a) Product. Calcium chloride. (b) Conditions of use. This substance (b) Conditions of use. This substance is generally recognized as safe when is generally recognized as safe when used in accordance with good manufac- used in accordance with good manufac- turing or feeding practice. turing or feeding practice. § 582.1275 Dextrans. § 582.1195 Calcium citrate. (a) Product. Dextrans of average mo- (a) Product. Calcium citrate. lecular weight below 100,000. (b) Conditions of use. This substance (b) Conditions of use. This substance is generally recognized as safe when is generally recognized as safe when used in accordance with good manufac- used in accordance with good manufac- turing or feeding practice. turing or feeding practice.

§ 582.1199 Calcium gluconate. § 582.1320 Glycerin. (a) Product. Calcium gluconate. (a) Product. Glycerin. (b) Conditions of use. This substance (b) Conditions of use. This substance is generally recognized as safe when is generally recognized as safe when used in accordance with good manufac- used in accordance with good manufac- turing or feeding practice. turing or feeding practice.

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§ 582.1324 Glyceryl monostearate. (b) Conditions of use. This substance is generally recognized as safe when (a) Product. Glyceryl monostearate. used in accordance with good manufac- (b) Conditions of use. This substance turing or feeding practice. is generally recognized as safe when used in accordance with good manufac- § 582.1500 Monoammonium glutamate. turing or feeding practice. (a) Product. Monoammonium glu- § 582.1355 Helium. tamate. (b) Conditions of use. This substance (a) Product. Helium. is generally recognized as safe when (b) Conditions of use. This substance used in accordance with good manufac- is generally recognized as safe when turing or feeding practice. used in accordance with good manufac- turing or feeding practice. § 582.1516 Monopotassium glutamate. § 582.1366 Hydrogen peroxide. (a) Product. Monopotassium glu- tamate. (a) Product. Hydrogen peroxide. (b) Conditions of use. This substance (b) [Reserved] is generally recognized as safe when (c) Limitations, restrictions, or expla- used in accordance with good manufac- nation. This substance is generally rec- turing or feeding practice. ognized as safe when used as a bleach- ing agent in accordance with good § 582.1540 Nitrogen. manufacturing or feeding practice. (a) Product. Nitrogen. § 582.1400 Lecithin. (b) Conditions of use. This substance is generally recognized as safe when (a) Product. Lecithin. used in accordance with good manufac- (b) Conditions of use. This substance turing or feeding practice. is generally recognized as safe when used in accordance with good manufac- § 582.1585 Papain. turing or feeding practice. (a) Product. Papain. (b) Conditions of use. This substance § 582.1425 Magnesium carbonate. is generally recognized as safe when (a) Product. Magnesium carbonate. used in accordance with good manufac- (b) Conditions of use. This substance turing or feeding practice. is generally recognized as safe when used in accordance with good manufac- § 582.1613 Potassium bicarbonate. turing or feeding practice. (a) Product. Potassium bicarbonate. (b) Conditions of use. This substance § 582.1428 Magnesium hydroxide. is generally recognized as safe when (a) Product. Magnesium hydroxide. used in accordance with good manufac- (b) Conditions of use. This substance turing or feeding practice. is generally recognized as safe when used in accordance with good manufac- § 582.1619 Potassium carbonate. turing or feeding practice. (a) Product. Potassium carbonate. (b) Conditions of use. This substance § 582.1431 Magnesium oxide. is generally recognized as safe when (a) Product. Magnesium oxide. used in accordance with good manufac- (b) Conditions of use. This substance turing or feeding practice. is generally recognized as safe when used in accordance with good manufac- § 582.1625 Potassium citrate. turing or feeding practice. (a) Product. Potassium citrate. (b) Conditions of use. This substance § 582.1480 Methylcellulose. is generally recognized as safe when (a) Product. U.S.P. methylcellulose, used in accordance with good manufac- except that the methoxy content shall turing or feeding practice. not be less than 27.5 percent and not more than 31.5 percent on a dry-weight § 582.1631 Potassium hydroxide. basis. (a) Product. Potassium hydroxide.

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(b) Conditions of use. This substance (b) Conditions of use. This substance is generally recognized as safe when is generally recognized as safe when used in accordance with good manufac- used in accordance with good manufac- turing or feeding practice. turing or feeding practice.

§ 582.1643 Potassium sulfate. § 582.1742 Sodium carbonate. (a) Product. Potassium sulfate. (a) Product. Sodium carbonate. (b) Conditions of use. This substance (b) Conditions of use. This substance is generally recognized as safe when is generally recognized as safe when used in accordance with good manufac- used in accordance with good manufac- turing or feeding practice. turing or feeding practice. § 582.1655 Propane. § 582.1745 Sodium (a) Product. Propane. carboxymethylcellulose. (b) Conditions of use. This substance is generally recognized as safe when (a) Product. Sodium carboxymethyl- used in accordance with good manufac- cellulose is the sodium salt of turing or feeding practice. carboxymethylcellulose not less than 99.5 percent on a dry-weight basis, with § 582.1666 Propylene glycol. maximum substitution of 0.95 (a) Product. Propylene glycol. carboxymethyl groups per (b) Conditions of use. This substance anhydroglucose unit, and with a min- is generally recognized as safe (except imum viscosity of 25 centipoises for 2 in cat food) when used in accordance percent by weight aqueous solution at with good manufacturing or feeding 25 °C. practice. (b) Conditions of use. This substance is generally recognized as safe when [41 FR 38657, Sept. 10, 1976, as amended at 61 FR 19544, May 2, 1996] used in accordance with good manufac- turing or feeding practice. § 582.1685 Rennet. § 582.1748 Sodium caseinate. (a) Product. Rennet (rennin). (b) Conditions of use. This substance (a) Product. Sodium caseinate. is generally recognized as safe when (b) Conditions of use. This substance used in accordance with good manufac- is generally recognized as safe when turing or feeding practice. used in accordance with good manufac- turing or feeding practice. § 582.1711 Silica aerogel. (a) Product. Silica aerogel as a finely § 582.1751 Sodium citrate. powdered microcellular silica foam (a) Product. Sodium citrate. having a minimum silica content of (b) Conditions of use. This substance 89.5 percent. is generally recognized as safe when (b) [Reserved] used in accordance with good manufac- (c) Limitations, restrictions, or expla- turing or feeding practice. nation. This substance is generally rec- ognized as safe when used as a compo- § 582.1763 Sodium hydroxide. nent of antifoaming agents in accord- ance with good manufacturing or feed- (a) Product. Sodium hydroxide. ing practice. (b) Conditions of use. This substance is generally recognized as safe when § 582.1721 Sodium acetate. used in accordance with good manufac- (a) Product. Sodium acetate. turing or feeding practice. (b) Conditions of use. This substance is generally recognized as safe when § 582.1775 Sodium pectinate. used in accordance with good manufac- (a) Product. Sodium pectinate. turing or feeding practice. (b) Conditions of use. This substance is generally recognized as safe when § 582.1736 Sodium bicarbonate. used in accordance with good manufac- (a) Product. Sodium bicarbonate. turing or feeding practice.

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§ 582.1778 Sodium phosphate. (b) Conditions of use. This substance (a) Product. Sodium phosphate is generally recognized as safe when (mono-, di-, and tribasic). used in accordance with good manufac- (b) Conditions of use. This substance turing or feeding practice. is generally recognized as safe when § 582.1978 . used in accordance with good manufac- turing or feeding practice. (a) Product. Carnauba wax. (b) Conditions of use. This substance § 582.1781 Sodium aluminum phos- is generally recognized as safe when phate. used in accordance with good manufac- (a) Product. Sodium aluminum phos- turing or feeding practice. phate. (b) Conditions of use. This substance Subpart C—Anticaking Agents is generally recognized as safe when used in accordance with good manufac- § 582.2122 Aluminum calcium silicate. turing or feeding practice. (a) Product. Aluminum calcium sili- cate. § 582.1792 Sodium sesquicarbonate. (b) Tolerance. 2 percent. (a) Product. Sodium sesquicarbonate. (c) Limitations, restrictions, or expla- (b) Conditions of use. This substance nation. This substance is generally rec- is generally recognized as safe when ognized as safe when used in table salt used in accordance with good manufac- in accordance with good manufacturing turing or feeding practice. or feeding practice.

§ 582.1804 Sodium potassium tartrate. § 582.2227 Calcium silicate. (a) Product. Sodium potassium tar- (a) Product. Calcium silicate. trate. (b) Tolerance. 2 percent and 5 percent. (b) Conditions of use. This substance (c) Limitations, restrictions, or expla- is generally recognized as safe when nation. This substance is generally rec- used in accordance with good manufac- ognized as safe when used at levels not turing or feeding practice. exceeding 2 percent in table salt and 5 percent in baking powder in accordance § 582.1810 Sodium tripolyphosphate. with good manufacturing or feeding (a) Product. Sodium practice. tripolyphosphate. (b) Conditions of use. This substance § 582.2437 Magnesium silicate. is generally recognized as safe when (a) Product. Magnesium silicate. used in accordance with good manufac- (b) Tolerance. 2 percent. turing or feeding practice. (c) Limitations, restrictions, or expla- nation. This substance is generally rec- § 582.1901 Triacetin. ognized as safe when used in table salt (a) Product. Triacetin (glyceryl in accordance with good manufacturing triacetate). or feeding practice. (b) Conditions of use. This substance is generally recognized as safe when § 582.2727 Sodium aluminosilicate. used in accordance with good manufac- (a) Product. Sodium aluminosilicate turing or feeding practice. (sodium silicoaluminate). (b) Tolerance. This substance is gen- § 582.1973 Beeswax. erally recognized as safe for use at a (a) Product. Beeswax (yellow wax). level not exceeding 2 percent in accord- (b) Conditions of use. This substance ance with good manufacturing or feed- is generally recognized as safe when ing practice. used in accordance with good manufac- turing or feeding practice. § 582.2729 Hydrated sodium calcium aluminosilicate. § 582.1975 Bleached beeswax. (a) Product. Hydrated sodium calcium (a) Product. Bleached beeswax (white aluminosilicate (sodium calcium wax). silicoaluminate).

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(b) Tolerance. This substance is gen- when the total content of antioxidants erally recognized as safe for use at a is not over 0.02 percent of fat or oil level not exceeding 2 percent in accord- content including essential (volatile) ance with good manufacturing or feed- oil content of the food, provided the ing practice. substance is used in accordance with good manufacturing or feeding prac- § 582.2906 Tricalcium silicate. tice. (a) Product. Tricalcium silicate. (b) Tolerance. 2 percent. § 582.3149 Ascorbyl palmitate. (c) Limitations, restrictions, or expla- (a) Product. Ascorbyl palmitate. nation. This substance is generally rec- (b) Conditions of use. This substance ognized as safe when used in table salt is generally recognized as safe when in accordance with good manufacturing used in accordance with good manufac- or feeding practice. turing or feeding practice.

Subpart D—Chemical § 582.3169 Butylated hydroxyanisole. Preservatives (a) Product. Butylated hydroxy- anisole. § 582.3013 Ascorbic acid. (b) Tolerance. This substance is gen- erally recognized as safe for use in food (a) Product. Ascorbic acid. when the total content of antioxidants (b) Conditions of use. This substance is not over 0.02 percent of fat or oil is generally recognized as safe when content, including essential (volatile) used in accordance with good manufac- oil content of food provided the sub- turing or feeding practice. stance is used in accordance with good § 582.3021 Benzoic acid. manufacturing or feeding practice. (a) Product. Benzoic acid. § 582.3173 Butylated hydroxytoluene. (b) Tolerance. This substance is gen- (a) Product. Butylated hydroxytol- erally recognized as safe for use at a uene. level not exceeding 0.1 percent in ac- (b) Tolerance. This substance is gen- cordance with good manufacturing or erally recognized as safe for use in food feeding practice. when the total content of antioxidants is not over 0.02 percent of fat or oil § 582.3041 Erythorbic acid. content, including essential (volatile) (a) Product. Erythorbic acid. oil content of food provided the sub- (b) Conditions of use. This substance stance is used in accordance with good is generally recognized as safe when manufacturing or feeding practice. used in accordance with good manufac- turing or feeding practice. § 582.3189 Calcium ascorbate. (a) Product. Calcium ascorbate. § 582.3081 Propionic acid. (b) Conditions of use. This substance (a) Product. Propionic acid. is generally recognized as safe when (b) Conditions of use. This substance used in accordance with good manufac- is generally recognized as safe when turing or feeding practice. used in accordance with good manufac- turing or feeding practice. § 582.3221 Calcium propionate. (a) Product. Calcium propionate. § 582.3089 Sorbic acid. (b) Conditions of use. This substance (a) Product. Sorbic acid. is generally recognized as safe when (b) Conditions of use. This substance used in accordance with good manufac- is generally recognized as safe when turing or feeding practice. used in accordance with good manufac- turing or feeding practice. § 582.3225 Calcium sorbate. (a) Product. Calcium sorbate. § 582.3109 Thiodipropionic acid. (b) Conditions of use. This substance (a) Product. Thiodipropionic acid. is generally recognized as safe when (b) Tolerance. This substance is gen- used in accordance with good manufac- erally recognized as safe for use in food turing or feeding practice.

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§ 582.3280 Dilauryl thiodipropionate. used in accordance with good manufac- turing or feeding practice. (a) Product. Dilauryl thiodipropionate. § 582.3660 Propyl gallate. (b) Tolerance. This substance is gen- erally recognized as safe for use in food (a) Product. Propyl gallate. when the total content of antioxidants (b) Tolerance. This substance is gen- is not over 0.02 percent of fat or oil erally recognized as safe for use in food content, including essential (volatile) when the total content of antioxidants oil content of the food, provided the is not over 0.02 percent of fat or oil substance is used in accordance with content, including essential (volatile) good manufacturing or feeding prac- oil content of the food, provided the tice. substance is used in accordance with good manufacturing or feeding prac- § 582.3336 Gum guaiac. tice. (a) Product. Gum guaiac. § 582.3670 Propylparaben. (b) Tolerance. 0.1 percent (equivalent antioxidant activity 0.01 percent). (a) Product. Propylparaben (propyl p- (c) Limitations, restrictions, or expla- hydroxybenzoate). nation. This substance is generally rec- (b) Tolerance. This substance is gen- ognized as safe when used in edible fats erally recognized as safe for use at a or oils in accordance with good manu- level not exceeding 0.1 percent in ac- facturing or feeding practice. cordance with good manufacturing or feeding practice. § 582.3490 Methylparaben. § 582.3731 Sodium ascorbate. (a) Product. Methylparaben (methyl p-hydroxybenzoate). (a) Product. Sodium ascorbate. (b) Tolerance. This substance is gen- (b) Conditions of use. This substance erally recognized as safe for use at a is generally recognized as safe when level not exceeding 0.1 percent in ac- used in accordance with good manufac- cordance with good manufacturing or turing or feeding practice. feeding practice. § 582.3733 Sodium benzoate. § 582.3616 Potassium bisulfite. (a) Product. Sodium benzoate. (a) Product. Potassium bisulfite. (b) Tolerance. This substance is gen- (b) [Reserved] erally recognized as safe for use at a (c) Limitations, restrictions, or expla- level not exceeding 0.1 percent in ac- nation. This substance is generally rec- cordance with good manufacturing or ognized as safe when used in accord- feeding practice. ance with good manufacturing or feed- ing practice, except that it is not used § 582.3739 Sodium bisulfite. in meats or in food recognized as (a) Product. Sodium bisulfite. source of vitamin B1. (b) [Reserved] (c) Limitations, restrictions, or expla- § 582.3637 Potassium metabisulfite. nation. This substance is generally rec- (a) Product. Potassium metabisulfite. ognized as safe when used in accord- (b) [Reserved] ance with good manufacturing or feed- (c) Limitations, restrictions, or expla- ing practice, except that it is not used nation. This substance is generally rec- in meats or in food recognized as ognized as safe when used in accord- source of vitamin B1. ance with good manufacturing or feed- ing practice, except that it is not used § 582.3766 Sodium metabisulfite. in meats or in food recognized as (a) Product. Sodium metabisulfite. source of vitamin B1. (b) [Reserved] (c) Limitations, restrictions, or expla- § 582.3640 Potassium sorbate. nation. This substance is generally rec- (a) Product. Potassium sorbate. ognized as safe when used in accord- (b) Conditions of use. This substance ance with good manufacturing or feed- is generally recognized as safe when ing practice, except that it is not used

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in meats or in food recognized as Subpart E—Emulsifying Agents source of vitamin B1. § 582.4101 Diacetyl tartaric acid esters § 582.3784 Sodium propionate. of mono- and diglycerides of edible fats or oils, or edible fat-forming (a) Product. Sodium propionate. fatty acids. (b) Conditions of use. This substance (a) Product. Diacetyl tartaric acid is generally recognized as safe when esters of mono- and diglycerides of edi- used in accordance with good manufac- ble fats or oils, or edible fat-forming turing or feeding practice. fatty acids. (b) Conditions of use. This substance § 582.3795 Sodium sorbate. is generally recognized as safe when (a) Product. Sodium sorbate. used in accordance with good manufac- (b) Conditions of use. This substance turing or feeding practice. is generally recognized as safe when used in accordance with good manufac- § 582.4505 Mono- and diglycerides of turing or feeding practice. edible fats or oils, or edible fat- forming acids. § 582.3798 Sodium sulfite. (a) Product. Mono- and diglycerides of edible fats or oils, or edible fat-forming (a) Product. Sodium sulfite. acids. (b) [Reserved] (b) Conditions of use. This substance (c) Limitations, restrictions, or expla- is generally recognized as safe when nation. This substance is generally rec- used in accordance with good manufac- ognized as safe when used in accord- turing or feeding practice. ance with good manufacturing or feed- ing practice, except that it is not used § 582.4521 Monosodium phosphate de- in meats or in food recognized as rivatives of mono- and diglycerides source of vitamin B . of edible fats or oils, or edible fat- 1 forming fatty acids. § 582.3845 Stannous chloride. (a) Product. Monosodium phosphate derivatives of mono- and diglycerides (a) Product. Stannous chloride. of edible fats or oils, or edible fat-form- (b) Tolerance. This substance is gen- ing fatty acids. erally recognized as safe for use at a (b) Conditions of use. This substance level not exceeding 0.0015 percent cal- is generally recognized as safe when culated as tin in accordance with good used in accordance with good manufac- manufacturing or feeding practice. turing or feeding practice.

§ 582.3862 Sulfur dioxide. § 582.4666 Propylene glycol. (a) Product. Sulfur dioxide. (a) Product. Propylene glycol. (b) [Reserved] (b) Conditions of use. This substance (c) Limitations, restrictions, or expla- is generally recognized as safe when nation. This substance is generally rec- used in accordance with good manufac- ognized as safe when used in accord- turing or feeding practice. ance with good manufacturing or feed- ing practice, except that it is not used Subpart F—Nutrients and/or in meats or in food recognized as Dietary Supplements 1 source of vitamin B . 1 § 582.5013 Ascorbic acid. § 582.3890 Tocopherols. (a) Product. Ascorbic acid. (a) Product. Tocopherols. (b) Conditions of use. This substance (b) Conditions of use. This substance is generally recognized as safe when used in accordance with good manufac- is generally recognized as safe when turing or feeding practice. used in accordance with good manufac- turing or feeding practice. 1 Amino acids listed in this subpart may be free hydrochloride salt, hydrated, or anhy- drous form, where applicable.

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§ 582.5017 Aspartic acid. § 582.5195 Calcium citrate. (a) Product. Aspartic acid (L- and DL- (a) Product. Calcium citrate. forms). (b) Conditions of use. This substance (b) Conditions of use. This substance is generally recognized as safe when is generally recognized as safe when used in accordance with good manufac- used in accordance with good manufac- turing or feeding practice. turing or feeding practice. § 582.5201 Calcium glycerophosphate. § 582.5049 Aminoacetic acid. (a) Product. Calcium (a) Product. Glycine (aminoacetic glycerophosphate. acid). (b) Conditions of use. This substance (b) [Reserved] is generally recognized as safe when (c) Limitations, restrictions, or expla- used in accordance with good manufac- nation. This substance is generally rec- turing or feeding practice. ognized as safe when used in animal § 582.5210 Calcium oxide. feeds in accordance with good manu- facturing or feeding practice. (a) Product. Calcium oxide. (b) Conditions of use. This substance § 582.5065 Linoleic acid. is generally recognized as safe when used in accordance with good manufac- (a) Product. Linoleic acid prepared turing or feeding practice. from edible fats and oils and free from chick-edema factor. § 582.5212 Calcium pantothenate. (b) Conditions of use. This substance is generally recognized as safe when (a) Product. Calcium pantothenate. used in accordance with good manufac- (b) Conditions of use. This substance turing or feeding practice. is generally recognized as safe when used in accordance with good manufac- § 582.5118 Alanine. turing or feeding practice. (a) Product. Alanine (L- and DL- § 582.5217 Calcium phosphate. forms). (a) Product. Calcium phosphate (b) Conditions of use. This substance (mono-, di-, and tribasic). is generally recognized as safe when (b) Conditions of use. This substance used in accordance with good manufac- is generally recognized as safe when turing or feeding practice. used in accordance with good manufac- § 582.5145 Arginine. turing or feeding practice. (a) Product. Arginine (L- and DL- § 582.5223 Calcium pyrophosphate. forms). (a) Product. Calcium pyrophosphate. (b) Conditions of use. This substance (b) Conditions of use. This substance is generally recognized as safe when is generally recognized as safe when used in accordance with good manufac- used in accordance with good manufac- turing or feeding practice. turing or feeding practice.

§ 582.5159 Biotin. § 582.5230 Calcium sulfate. (a) Product. Biotin. (a) Product. Calcium sulfate. (b) Conditions of use. This substance (b) Conditions of use. This substance is generally recognized as safe when is generally recognized as safe when used in accordance with good manufac- used in accordance with good manufac- turing or feeding practice. turing or feeding practice.

§ 582.5191 Calcium carbonate. § 582.5245 Carotene. (a) Product. Calcium carbonate. (a) Product. Carotene. (b) Conditions of use. This substance (b) Conditions of use. This substance is generally recognized as safe when is generally recognized as safe when used in accordance with good manufac- used in accordance with good manufac- turing or feeding practice. turing or feeding practice.

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§ 582.5250 Choline bitartrate. used in accordance with good manufac- turing or feeding practice. (a) Product. Choline bitartrate. (b) Conditions of use. This substance § 582.5308 Ferrous gluconate. is generally recognized as safe when used in accordance with good manufac- (a) Product. Ferrous gluconate. turing or feeding practice. (b) Conditions of use. This substance is generally recognized as safe when § 582.5252 Choline chloride. used in accordance with good manufac- turing or feeding practice. (a) Product. Choline chloride. (b) Conditions of use. This substance § 582.5311 Ferrous lactate. is generally recognized as safe when used in accordance with good manufac- (a) Product. Ferrous lactate. turing or feeding practice. (b) Conditions of use. This substance is generally recognized as safe when § 582.5260 Copper gluconate. used in accordance with good manufac- (a) Product. Copper gluconate. turing or feeding practice. (b) Tolerance. This substance is gen- § 582.5315 Ferrous sulfate. erally recognized as safe for use at a level not exceeding 0.005 percent in ac- (a) Product. Ferrous sulfate. cordance with good manufacturing or (b) Conditions of use. This substance feeding practice. is generally recognized as safe when used in accordance with good manufac- § 582.5271 Cysteine. turing or feeding practice. (a) Product. Cysteine (L-forms). § 582.5361 Histidine. (b) Conditions of use. This substance is generally recognized as safe when (a) Product. Histidine (L- and DL- used in accordance with good manufac- forms). turing or feeding practice. (b) Conditions of use. This substance is generally recognized as safe when § 582.5273 Cystine. used in accordance with good manufac- (a) Product. Cystine (L- and DL- turing or feeding practice. forms). § 582.5370 Inositol. (b) Conditions of use. This substance is generally recognized as safe when (a) Product. Inositol. used in accordance with good manufac- (b) Conditions of use. This substance turing or feeding practice. is generally recognized as safe when used in accordance with good manufac- § 582.5301 Ferric phosphate. turing or feeding practice. (a) Product. Ferric phosphate. § 582.5375 Iron reduced. (b) Conditions of use. This substance is generally recognized as safe when (a) Product. Iron reduced. used in accordance with good manufac- (b) Conditions of use. This substance turing or feeding practice. is generally recognized as safe when used in accordance with good manufac- § 582.5304 Ferric pyrophosphate. turing or feeding practice. (a) Product. Ferric pyrophosphate. § 582.5381 Isoleucine. (b) Conditions of use. This substance is generally recognized as safe when (a) Product. Isoleucine (L- and DL- used in accordance with good manufac- forms). turing or feeding practice. (b) Conditions of use. This substance is generally recognized as safe when § 582.5306 Ferric sodium used in accordance with good manufac- pyrophosphate. turing or feeding practice. (a) Product. Ferric sodium pyrophosphate. § 582.5406 Leucine. (b) Conditions of use. This substance (a) Product. Leucine (L- and DL- is generally recognized as safe when forms).

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(b) Conditions of use. This substance § 582.5455 Manganese is generally recognized as safe when glycerophosphate. used in accordance with good manufac- (a) Product. Manganese turing or feeding practice. glycerophosphate. (b) Conditions of use. This substance § 582.5411 Lysine. is generally recognized as safe when (a) Product. Lysine (L- and DL- used in accordance with good manufac- forms). turing or feeding practice. (b) Conditions of use. This substance is generally recognized as safe when § 582.5458 Manganese hypophosphite. used in accordance with good manufac- (a) Product. Manganese turing or feeding practice. hypophosphite. (b) Conditions of use. This substance § 582.5431 Magnesium oxide. is generally recognized as safe when (a) Product. Magnesium oxide. used in accordance with good manufac- (b) Conditions of use. This substance turing or feeding practice. is generally recognized as safe when § 582.5461 Manganese sulfate. used in accordance with good manufac- turing or feeding practice. (a) Product. Manganese sulfate. (b) Conditions of use. This substance § 582.5434 Magnesium phosphate. is generally recognized as safe when used in accordance with good manufac- (a) Product. Magnesium phosphate turing or feeding practice. (di- and tribasic). (b) Conditions of use. This substance § 582.5464 Manganous oxide. is generally recognized as safe when (a) Product. Manganous oxide. used in accordance with good manufac- (b) Conditions of use. This substance turing or feeding practice. is generally recognized as safe when § 582.5443 Magnesium sulfate. used in accordance with good manufac- turing or feeding practice. (a) Product. Magnesium sulfate. (b) Conditions of use. This substance § 582.5470 Mannitol. is generally recognized as safe when (a) Product. Mannitol. used in accordance with good manufac- (b) Conditions of use. This substance turing or feeding practice. is generally recognized as safe when used in accordance with good manufac- § 582.5446 Manganese chloride. turing or feeding practice. (a) Product. Manganese chloride. (b) Conditions of use. This substance § 582.5475 Methionine. is generally recognized as safe when (a) Product. Methionine. used in accordance with good manufac- (b) [Reserved] turing or feeding practice. (c) Limitations, restrictions, or expla- nation. This substance is generally rec- § 582.5449 Manganese citrate. ognized as safe when used in animal (a) Product. Manganese citrate. feeds in accordance with good manu- (b) Conditions of use. This substance facturing or feeding practice. is generally recognized as safe when § 582.5477 Methionine hydroxy analog used in accordance with good manufac- and its calcium salts. turing or feeding practice. (a) Product. Methionine hydroxy ana- § 582.5452 Manganese gluconate. log and its calcium salts. (b) [Reserved] (a) Product. Manganese gluconate. (c) Limitations, restrictions, or expla- (b) Conditions of use. This substance nation. This substance is generally rec- is generally recognized as safe when ognized as safe when used in animal used in accordance with good manufac- feeds in accordance with good manu- turing or feeding practice. facturing or feeding practice.

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§ 582.5530 Niacin. (b) Conditions of use. This substance (a) Product. Niacin. is generally recognized as safe when (b) Conditions of use. This substance used in accordance with good manufac- is generally recognized as safe when turing or feeding practice. used in accordance with good manufac- § 582.5676 Pyridoxine hydrochloride. turing or feeding practice. (a) Product. Pyridoxine hydro- § 582.5535 Niacinamide. chloride. (a) Product. Niacinamide. (b) Conditions of use. This substance (b) Conditions of use. This substance is generally recognized as safe when is generally recognized as safe when used in accordance with good manufac- used in accordance with good manufac- turing or feeding practice. turing or feeding practice. § 582.5695 Riboflavin. § 582.5580 D-Pantothenyl alcohol. (a) Product. Riboflavin. (a) Product. D-Pantothenyl alcohol. (b) Conditions of use. This substance (b) Conditions of use. This substance is generally recognized as safe when is generally recognized as safe when used in accordance with good manufac- used in accordance with good manufac- turing or feeding practice. turing or feeding practice. § 582.5697 Riboflavin-5-phosphate. § 582.5590 Phenylalanine. (a) Product. Riboflavin-5-phosphate. (a) Product. Phenylalanine (L- and (b) Conditions of use. This substance DL-forms). is generally recognized as safe when (b) Conditions of use. This substance used in accordance with good manufac- is generally recognized as safe when turing or feeding practice. used in accordance with good manufac- turing or feeding practice. § 582.5701 Serine. (a) Product. Serine (L- and DL-forms). § 582.5622 Potassium chloride. (b) Conditions of use. This substance (a) Product. Potassium chloride. is generally recognized as safe when (b) Conditions of use. This substance used in accordance with good manufac- is generally recognized as safe when turing or feeding practice. used in accordance with good manufac- turing or feeding practice. § 582.5772 Sodium pantothenate. (a) Product. Sodium pantothenate. § 582.5628 Potassium (b) Conditions of use. This substance glycerophosphate. is generally recognized as safe when (a) Product. Potassium used in accordance with good manufac- glycerophosphate. turing or feeding practice. (b) Conditions of use. This substance is generally recognized as safe when § 582.5778 Sodium phosphate. used in accordance with good manufac- (a) Product. Sodium phosphate turing or feeding practice. (mono-, di-, and tribasic). (b) Conditions of use. This substance § 582.5634 Potassium iodide. is generally recognized as safe when (a) Product. Potassium iodide. used in accordance with good manufac- (b) Tolerance. 0.01 percent. turing or feeding practice. (c) Limitations, restrictions, or expla- nation. This substance is generally rec- § 582.5835 Sorbitol. ognized as safe when used in table salt (a) Product. Sorbitol. as a source of dietary iodine in accord- (b) Conditions of use. This substance ance with good manufacturing or feed- is generally recognized as safe when ing practice. used in accordance with good manufac- turing or feeding practice. § 582.5650 Proline. (a) Product. Proline (L- and DL- § 582.5875 Thiamine hydrochloride. forms). (a) Product. Thiamine hydrochloride.

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(b) Conditions of use. This substance § 582.5930 Vitamin A. is generally recognized as safe when (a) Product. Vitamin A. used in accordance with good manufac- (b) Conditions of use. This substance turing or feeding practice. is generally recognized as safe when used in accordance with good manufac- § 582.5878 Thiamine mononitrate. turing or feeding practice. (a) Product. Thiamine mononitrate. (b) Conditions of use. This substance § 582.5933 Vitamin A acetate. is generally recognized as safe when (a) Product. Vitamin A acetate. used in accordance with good manufac- (b) Conditions of use. This substance turing or feeding practice. is generally recognized as safe when used in accordance with good manufac- § 582.5881 Threonine. turing or feeding practice. (a) Product. Threonine (L- and DL- forms). § 582.5936 Vitamin A palmitate. (b) Conditions of use. This substance (a) Product. Vitamin A palmitate. is generally recognized as safe when (b) Conditions of use. This substance used in accordance with good manufac- is generally recognized as safe when turing or feeding practice. used in accordance with good manufac- turing or feeding practice. § 582.5890 Tocopherols. § 582.5945 Vitamin B . (a) Product. Tocopherols. 2 (b) Conditions of use. This substance (a) Product. Vitamin B12. is generally recognized as safe when (b) Conditions of use. This substance used in accordance with good manufac- is generally recognized as safe when turing or feeding practice. used in accordance with good manufac- turing or feeding practice. § 582.5892 a-Tocopherol acetate. § 582.5950 Vitamin D2. (a) Product. a-Tocopherol acetate. (a) Product. Vitamin D . (b) Conditions of use. This substance 2 (b) Conditions of use. This substance is generally recognized as safe when is generally recognized as safe when used in accordance with good manufac- used in accordance with good manufac- turing or feeding practice. turing or feeding practice. § 582.5915 Tryptophane. § 582.5953 Vitamin D2. (a) Product. Tryptophane (L- and DL- (a) Product. Vitamin D3. forms). (b) Conditions of use. This substance (b) Conditions of use. This substance is generally recognized as safe when is generally recognized as safe when used in accordance with good manufac- used in accordance with good manufac- turing or feeding practice. turing or feeding practice. § 582.5985 Zinc chloride. § 582.5920 Tyrosine. (a) Product. Zinc chloride. (a) Product. Tyrosine (L- and DL- (b) Conditions of use. This substance forms). is generally recognized as safe when (b) Conditions of use. This substance used in accordance with good manufac- is generally recognized as safe when turing or feeding practice. used in accordance with good manufac- turing or feeding practice. § 582.5988 Zinc gluconate. (a) Product. Zinc gluconate. § 582.5925 Valine. (b) Conditions of use. This substance (a) Product. Valine (L- and DL- is generally recognized as safe when forms). used in accordance with good manufac- (b) Conditions of use. This substance turing or feeding practice. is generally recognized as safe when used in accordance with good manufac- § 582.5991 Zinc oxide. turing or feeding practice. (a) Product. Zinc oxide.

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(b) Conditions of use. This substance (b) Conditions of use. This substance is generally recognized as safe when is generally recognized as safe when used in accordance with good manufac- used in accordance with good manufac- turing or feeding practice. turing or feeding practice.

§ 582.5994 Zinc stearate. § 582.6195 Calcium citrate. (a) Product. Zinc stearate prepared (a) Product. Calcium citrate. from stearic acid free from chick- (b) Conditions of use. This substance edema factor. is generally recognized as safe when (b) Conditions of use. This substance used in accordance with good manufac- is generally recognized as safe when turing or feeding practice. used in accordance with good manufac- turing or feeding practice. § 582.6197 Calcium diacetate. § 582.5997 Zinc sulfate. (a) Product. Calcium diacetate. (b) Conditions of use. This substance (a) Zinc sulfate. Product. is generally recognized as safe when (b) This substance Conditions of use. used in accordance with good manufac- is generally recognized as safe when turing or feeding practice. used in accordance with good manufac- turing or feeding practice. § 582.6199 Calcium gluconate. Subpart G—Sequestrants 2 (a) Product. Calcium gluconate. (b) Conditions of use. This substance § 582.6033 Citric acid. is generally recognized as safe when used in accordance with good manufac- (a) Product. Citric acid. turing or feeding practice. (b) Conditions of use. This substance is generally recognized as safe when § 582.6203 Calcium used in accordance with good manufac- hexametaphosphate. turing or feeding practice. (a) Product. Calcium § 582.6085 Sodium acid phosphate. hexametaphosphate. (b) Conditions of use. This substance (a) Product. Sodium acid phosphate. is generally recognized as safe when (b) Conditions of use. This substance used in accordance with good manufac- is generally recognized as safe when turing or feeding practice. used in accordance with good manufac- turing or feeding practice. § 582.6215 Monobasic calcium phos- phate. § 582.6099 Tartaric acid. (a) Product. Monobasic calcium phos- (a) Product. Tartaric acid. phate. (b) Conditions of use. This substance is generally recognized as safe when (b) Conditions of use. This substance used in accordance with good manufac- is generally recognized as safe when turing or feeding practice. used in accordance with good manufac- turing or feeding practice. § 582.6185 Calcium acetate. § 582.6219 Calcium phytate. (a) Product. Calcium acetate. (b) Conditions of use. This substance (a) Product. Calcium phytate. is generally recognized as safe when (b) Conditions of use. This substance used in accordance with good manufac- is generally recognized as safe when turing or feeding practice. used in accordance with good manufac- turing or feeding practice. § 582.6193 Calcium chloride. (a) Product. Calcium chloride. § 582.6285 Dipotassium phosphate. (a) Product. Dipotassium phosphate. 2 For the purpose of this subpart, no at- (b) Conditions of use. This substance tempt has been made to designate those is generally recognized as safe when sequestrants that may also function as used in accordance with good manufac- chemical preservatives. turing or feeding practice.

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§ 582.6290 Disodium phosphate. (b) Conditions of use. This substance (a) Product. Disodium phosphate. is generally recognized as safe when (b) Conditions of use. This substance used in accordance with good manufac- is generally recognized as safe when turing or feeding practice. used in accordance with good manufac- § 582.6769 Sodium metaphosphate. turing or feeding practice. (a) Product. Sodium metaphosphate. § 582.6386 Isopropyl citrate. (b) Conditions of use. This substance (a) Product. Isopropyl citrate. is generally recognized as safe when (b) Tolerance. This substance is gen- used in accordance with good manufac- erally recognized as safe for use at a turing or feeding practice. level not exceeding 0.02 percent in ac- § 582.6778 Sodium phosphate. cordance with good manufacturing or feeding practice. (a) Product. Sodium phosphate (mono-, di-, and tribasic). § 582.6511 Monoisopropyl citrate. (b) Conditions of use. This substance (a) Product. Monoisopropyl citrate. is generally recognized as safe when (b) Conditions of use. This substance used in accordance with good manufac- is generally recognized as safe when turing or feeding practice. used in accordance with good manufac- § 582.6787 Sodium pyrophosphate. turing or feeding practice. (a) Product. Sodium pyrophosphate. § 582.6625 Potassium citrate. (b) Condition of use. This substance is (a) Product. Potassium citrate. generally recognized as safe when used (b) Conditions of use. This substance in accordance with good manufacturing is generally recognized as safe when or feeding practice. used in accordance with good manufac- § 582.6789 Tetra sodium turing or feeding practice. pyrophosphate. [41 FR 38657, Sept. 10, 1976. Redesignated at (a) Product. Tetra sodium 42 FR 14091, Mar. 15, 1977] pyrophosphate. (b) Conditions of use. This substance § 582.6751 Sodium citrate. is generally recognized as safe when (a) Product. Sodium citrate. used in accordance with good manufac- (b) Conditions of use. This substance turing or feeding practice. is generally recognized as safe when used in accordance with good manufac- § 582.6801 Sodium tartrate. turing or feeding practice. (a) Product. Sodium tartrate. [41 FR 38657, Sept. 10, 1976. Redesignated at (b) Conditions of use. This substance 42 FR 14091, Mar. 15, 1977] is generally recognized as safe when used in accordance with good manufac- § 582.6754 Sodium diacetate. turing or feeding practice. (a) Product. Sodium diacetate. (b) Conditions of use. This substance § 582.6804 Sodium potassium tartrate. is generally recognized as safe when (a) Product. Sodium potassium tar- used in accordance with good manufac- trate. turing or feeding practice. (b) Conditions of use. This substance is generally recognized as safe when § 582.6757 Sodium gluconate. used in accordance with good manufac- (a) Product. Sodium gluconate. turing or feeding practice. (b) Conditions of use. This substance is generally recognized as safe when § 582.6807 Sodium thiosulfate. used in accordance with good manufac- (a) Product. Sodium thiosulfate. turing or feeding practice. (b) Tolerance. 0.1 percent. (c) Limitations, restrictions, or expla- § 582.6760 Sodium nation. This substance is generally rec- hexametaphosphate. ognized as safe when used in salt in ac- (a) Product. Sodium cordance with good manufacturing or hexametaphosphate. feeding practice.

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§ 582.6810 Sodium tripolyphosphate. used in accordance with good manufac- (a) Product. Sodium turing or feeding practice. tripolyphosphate. (b) Conditions of use. This substance § 582.7339 Guar gum. is generally recognized as safe when (a) Product. Guar gum. used in accordance with good manufac- (b) Conditions of use. This substance turing or feeding practice. is generally recognized as safe when used in accordance with good manufac- § 582.6851 Stearyl citrate. turing or feeding practice. (a) Product. Stearyl citrate. (b) Tolerance. This substance is gen- § 582.7343 Locust bean gum. erally recognized as safe for use at a (a) Product. Locust (carob) bean gum. level not exceeding 0.15 percent in ac- (b) Conditions of use. This substance cordance with good manufacturing or is generally recognized as safe when feeding practice. used in accordance with good manufac- Subpart H—Stabilizers turing or feeding practice. § 582.7349 Sterculia gum. § 582.7115 Agar-agar. (a) Product. Agar-agar. (a) Product. Sterculia gum (karaya (b) Conditions of use. This substance gum). is generally recognized as safe when (b) Conditions of use. This substance used in accordance with good manufac- is generally recognized as safe when turing or feeding practice. used in accordance with good manufac- turing or feeding practice. § 582.7133 Ammonium alginate. (a) Product. Ammonium alginate. § 582.7351 Gum tragacanth. (b) Conditions of use. This substance (a) Product. Tragacanth (gum is generally recognized as safe when tragacanth). used in accordance with good manufac- (b) Conditions of use. This substance turing or feeding practice. is generally recognized as safe when § 582.7187 Calcium alginate. used in accordance with good manufac- turing or feeding practice. (a) Product. Calcium alginate. (b) Conditions of use. This substance § 582.7610 Potassium alginate. is generally recognized as safe when used in accordance with good manufac- (a) Product. Potassium alginate. turing or feeding practice. (b) Conditions of use. This substance is generally recognized as safe when § 582.7255 Chondrus extract. used in accordance with good manufac- (a) Product. Chondrus extract turing or feeding practice. (carrageenin). (b) Conditions of use. This substance § 582.7724 Sodium alginate. is generally recognized as safe when (a) Product. Sodium alginate. used in accordance with good manufac- (b) Conditions of use. This substance turing or feeding practice. is generally recognized as safe when used in accordance with good manufac- § 582.7330 Gum arabic. turing or feeding practice. (a) Product. Acacia (gum arabic). (b) Conditions of use. This substance is generally recognized as safe when PART 584—FOOD SUBSTANCES AF- used in accordance with good manufac- FIRMED AS GENERALLY RECOG- turing or feeding practice. NIZED AS SAFE IN FEED AND DRINKING WATER OF ANIMALS § 582.7333 Gum ghatti. (a) Product. Gum ghatti. Subpart A [Reserved] (b) Conditions of use. This substance is generally recognized as safe when

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